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Infant Motor Development Predicts The Dynamics Of Movement During Sleep, Aaron Demasi, Melissa N. Horger, Anat Scher, Sarah E. Berger

Publications and Research

The characteristics of infant sleep change over the first year. Generally, infants wake and move less at night as they grow older. However, acquisition of new motor skills leads to temporary increases in night waking and movement at night. Indeed, sleep-dependent movement at night is important for sensorimotor development. Nevertheless, little is known about how movement during sleep changes as infants accrue locomotor experience. The current study investigated whether infant sleep and movement during sleep were predicted by infants' walking experience. Seventy-eight infants wore an actigraph to measure physical activity during sleep. Parents reported when their infants first walked across …

Importin-Mediated Pathological Tau Nuclear Translocation Causes Disruption Of The Nuclear Lamina, Tdp-43 Mislocalization And Cell Death, Robert F. Candia, Leah S. Cohen, Viktoriya Morozova, Christopher Corbo, Alejandra D. Alonso

Publications and Research

Tau is a cytosolic protein that has also been observed in the nucleus, where it has multiple proposed functions that are regulated by phosphorylation. However, the mechanism underlying the nuclear import of tau is unclear, as is the contribution of nuclear tau to the pathology of tauopathies. We have previously generated a pathological form of tau, PH-tau (pseudophosphorylation mutants S199E, T212E, T231E, and S262E) that mimics AD pathological behavior in cells, Drosophila, and a mouse model. Here, we demonstrated that PH-tau translocates into the nucleus of transiently transfected HEK-293 cells, but wildtype tau does not. We identified a putative …

Unh: The Magazine Of The University Of New Hampshire, Winter 2022, Unh Magazine

UNH Magazine

This editon of UNH Magazine was digital only due to the COVID-19 Pandemic. This is an archived version of web content originally found at https://magazine.unh.edu/

How Adolescents In The Child Welfare System Seek Support For Their Sexual Risk Experiences Online, Taylor L. Moraguez

Honors Undergraduate Theses

Youth in the foster care system experience unique and challenging situations online, such as higher risks of inappropriate messaging (e.g., sexting) and unwanted solicitations from strangers. As a vulnerable group of adolescents, foster youth often use online platforms as a resource to express themselves and seek support over their sexual experiences online. This thesis analyzes how foster youth seek support online for their sexual risk experiences, including sexual abuse, sexting, and sexuality. To understand how adolescents (ages 13-17) in the child welfare system seek support for these experiences, we conducted a thematic analysis of 541 individual posts made by 121 …

Complex Quantum Contagion: A Quantum-Like Approach For The Analysis Of Co-Evolutionary Dynamics Of Social Contagion, Ece Mutlu

Electronic Theses and Dissertations, 2020-2023

Modeling the dynamics of social contagion processes has recently attracted a substantial amount of interest from researchers due to its wide applicability in network science, multi-agent systems, information science, and marketing. Unlike in biological spreading, the existence of a reinforcement effect in social contagion necessitates considering the complexity of individuals in the systems. Although many studies acknowledged the heterogeneity of the individuals in their adoption of information (or behavior), there are no studies that take into account the individuals' uncertainty during their decision-making despite its theoretical and experimental evidence in behavioral economics, decision science, cognitive science, or multi-agent systems. This …

Black Bears In Suburban Areas Consume More Anthropogenic Foods, Alexander Arroyo

IdeaFest 2022

No abstract provided.

What Can Aphasia Tell Us About How The First-Acquired Language Is Instantiated In The Brain?, Mira Goral

Publications and Research

Recent neurolinguistic theories converge on the hypothesis that the languages of multilingual people are processed as one system in the brain. One system for the multiple languages is also at the core of a translanguaging framework of multilingualism—a framework that focuses on each speaker’s complete linguistic repertoire rather than on the separate languages they know. However, evidence from neuroimaging studies suggests at least some nonoverlapping activations of the first-acquired language (L1) and other (non-L1) languages of multilingual people, especially when the age of acquisition and/or levels of proficiency differ across the languages. Neurolinguistic studies of acquired language disorders have demonstrated …

A Computational Study Of The Acidity Of Glufosinate Derivatives, Daniel Sabo

IdeaFest 2022

No abstract provided.

Development And Characterisation Of A Whole Hybrid Sol-Gel Optofluidic Platform For Biosensing Applications, Emma Mchugh, Graceson Antony, Arun Kumar Mallik, Alicja Kaworek, Declan Mccormack, Brendan Duffy, Mohamed Oubaha

Articles

This work outlines, for the first time, the fabrication of a whole hybrid sol-gel optofluidic platform by integrating a microfluidic biosensor platform with optical waveguides employing a standard photolithography process. To demonstrate the suitability of this new hybrid sol-gel optofluidic platform, optical and bio-sensing proof-of-concepts are proposed. A photoreactive hybrid sol-gel material composed of a photopolymerisable organically modified silicon alkoxide and a transition metal complex was prepared and used as the fabrication material for the entire optofluidic platform, including the optical waveguides, the sensing areas, and the microfluidic device. The most suitable sol-gel materials chosen for the fabrication of the …

Does The Thermal Mismatch Hypothesis Predict Disease Outcomes In Different Morphs Of A Terrestrial Salamander?, Matthew D. Venesky, Joseph Demarchi, Cari-Ann M. Hickerson, Carl D. Anthony

2022 Faculty Bibliography

Many aspects of ectotherm physiology are temperature‐dependent. The immune system of temperate‐dwelling ectothermic host species is no exception and their immune function is often down regulated in cold temperatures. Likewise, species of ectothermic pathogens experience temperature‐mediated effects on rates of transmission and/or virulence. Although seemingly straightforward, predicting the outcomes of ectothermic host−pathogen interactions is quite challenging. A recent hypothesis termed the thermal mismatch hypothesis posits that cool‐adapted host species should be most susceptible to pathogen infection during warm temperature periods whereas warm‐adapted host species should be most susceptible to pathogens during periods of cool temperatures. We explore this hypothesis using …

Peroxide Antimalarial Drugs Target Redox Homeostasis In Plasmodium Falciparum Infected Red Blood Cells, Ghizal Siddiqui, Carlo Giannangelo, Amanda De Paoli, Anna Katharina Schuh, Kim C. Heimsch, Dovile Anderson, Timothy G. Brown, Christopher A. Macraild, Jianbo Wu, Xiaofang Wang, Yuxiang Dong, Jonathan L. Vennerstrom, Katja Becker, Darren J. Creek

Journal Articles: Pharmaceutical Sciences

Plasmodium falciparum causes the most lethal form of malaria. Peroxide antimalarials based on artemisinin underpin the frontline treatments for malaria, but artemisinin resistance is rapidly spreading. Synthetic peroxide antimalarials, known as ozonides, are in clinical development and offer a potential alternative. Here, we used chemoproteomics to investigate the protein alkylation targets of artemisinin and ozonide probes, including an analogue of the ozonide clinical candidate, artefenomel. We greatly expanded the list of proteins alkylated by peroxide antimalarials and identified significant enrichment of redox-related proteins for both artemisinins and ozonides. Disrupted redox homeostasis was confirmed by dynamic live imaging of the glutathione …

Emerging Investigator Series: Moving Beyond Resilience By Considering Antifragility In Potable Water Systems, Joseph E. Goodwill, Patrick Ray, Destenie Nock, Christopher M. Miller

Civil & Environmental Engineering Faculty Publications

It is inherently difficult to plan water systems for a future that is non-predictive. This paper introduces a novel perspective for the design and operation of potable water systems under increasing water quality volatility (e.g., a relatively rapid and unpredicted deviation from baseline water quality). Increased water quality volatility and deep uncertainty stress water systems, confound design decisions, and increase the risk of decreased water system performance. Recent emphasis on resilience in drinking water treatment has partly addressed this issue, but still establishes an adversarial relationship with change. An antifragile system benefits from volatile change. By incorporating antifragility, …

Foot Injuries In Michigan, Usa, Gray Wolves (Canis Lupus), 1992–2014, Daniel J. O'Brien, Dean E. Beyer Jr., Erin Largent, Julie R. Melotti, Caitlin N. Ott-Conn, Donald H. Lonsway, Thomas M. Cooley, Robert Atkinson, Michelle Clayson, Kelly A. Straka

United States Department of Agriculture Wildlife Services: Staff Publications

The range of gray wolves (Canis lupus) in the contiguous US is expanding. Research and monitoring to support population recovery and management often involves capture via foothold traps. A population-level epidemiologic assessment of the effect of trap injuries on wolf survival remains needed to inform management. We describe the baseline rate, type, and severity of foot injuries of wolves born 1992–2013 in Michigan’s Upper Peninsula, evaluate the reliability of field-scoring trap-related injuries, and the effect of injuries on wolf survival. We assessed foot injuries by physical and radiographic exam at postmortem and/or time of capture for 351 wolves using the …

Olfactory Lures In Predator Control Do Not Increase Predation Risk To Birds In Areas Of Conservation Concern, Page Klug, Amy A. Yackel Adams, Robert N. Reed

United States Department of Agriculture Wildlife Services: Staff Publications

Context. Lethal control of predators is often undertaken to protect species of conservation concern. Traps are frequently baited to increase capture efficacy, but baited traps can potentially increase predation risk by attracting predators to protected areas. This is especially important if targeted predators can escape capture due to low trap success. Snake traps using live mouse lures may be beneficial if traps effectively remove snakes in the presence of birds and do not attract additional snakes to the area.

Aims. The present study evaluated whether mouse-lure traps in areas occupied by birds (simulated by deploying birdlure traps) could influence predation …

Wild Pig Removal Reduces Pathogenic Bacteria In Low-Order Streams, Sara A. Bolds, B. Graeme Lockaby, Latif Kalin, Stephen S. Ditchkoff, Mark D. Smith, Kurt Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive wild pig populations have undergone enormous increases in the United States and particularly across the southern U.S. in recent years. High fecundity rates and abilities to adapt quickly to varied habitats have enabled pig populations to become entrenched and difficult to eliminate. The pigs cause many negative impacts on ecosystems including degradation of water quality through infusion of fecal contamination and other non-point source pollutants. Our goal was to determine the effects of pig removal on water quality in streams that were known to be significantly polluted by pig activity Bolds (J Environ Qual 50: 441–453, 2021). We compared …

Congressional Myopia In Biomedical Innovation Policy, W. Nicholson Price Ii

Reviews

Innovation policy is hard. Getting it right requires balancing incentives for developers, consumer access, rewards for later innovators, safety concerns, and other factors. This balance is vitally important and wickedly difficult—even when it’s the focus of concerted, careful, informed effort. How well should we expect it to go when innovation policy is made by accident? Enter The Accidental Innovation Policymakers, an illuminating new project by Professor Rachel Sachs. Sachs persuasively shows how Congress has repeatedly made substantial changes to innovation policy, seemingly without talking about, seriously considering, or even recognizing that it is doing so. There’s an asymmetry to this …

Criminal Acts And Basic Moral Equality, John A. Humbach

Elisabeth Haub School of Law Faculty Publications

Modern criminal justice presupposes that persons are not morally equal. On the contrary, those who do wrong are viewed by the law as less worthy of respect, concern and decent treatment: Offenders, it is said, “deserve” to suffer for their misdeeds. Yet, there is scant logical or empirical basis for the law's supposition that offenders are morally inferior. The usual reasoning is that persons who intentionally or knowingly do wrong are the authors and initiators of their acts and, as such, are morally responsible for them. But this reasoning rests on the assumption that a person's mental states, such as …

Uab Magazine - Spring/Summer 2022, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

Abortion And The Personhood Assumption: A New Defense Of Abortion On The Basis Of Self-Defense, Timothy Kirschenheiter

Wayne State University Dissertations

In this essay, I offer a new defense of abortion. I argue that even if we assume that the fetus is a person with full moral rights abortion is still generally morally permissible. For this argument, I rely on the concept of self-defense, arguing that abortion is morally permissible as a self-defensive action.

In Chapter II, I motivate the personhood assumption by finding and defending the strongest version of Don Marquis’s Future-Like-Ours Argument.

In Chapter III, I argue for the rejection of responsibility arguments in favor of the moral permissibility of abortion – the sort of arguments offered by Judith …

Ecological Predictors Of Sexual Well-Being In Women, Rachel Goutman

Wayne State University Dissertations

Previous research has shown that female sexuality continues to be suppressed in American society and as a result, women are not achieving their highest levels of sexual well-being (i.e., sexual self-concept, sexual assertiveness, and sexual satisfaction). Because sexual well-being is imperative to overall well-being, it is important for counseling psychologists to be sensitive to the potential role that ecological variables have on women’s current sexual well-being. Utilizing an ecological framework, the aims of this study were to deepen our understanding of how early life microsystem experiences relate to later sexual well-being in women, to assess how current macrosystem experiences of …

Childhood Sexual Abuse In Boys Under The Age Of 18: Nonverbal Disclosure Patterns Through Behavior, Matthew J. Luz

The Graduate Review

Adverse childhood experiences (ACE) include being exposed to or victimized by physical, emotional, or sexual abuse; if left untreated, traumas may disrupt normative biopsychosocial development. Childhood sexual abuse (CSA) is a phenomenon investigated by many researchers, however, the scientific community suspects CSA in boys is underreported. Since there are significant gender differences in CSA verbal disclosures, examining nonverbal disclosures in boys through overt, sexualized behaviors may help clinicians confirm suspected cases of CSA. Since most research investigates verbal disclosures of sexual abuse, this study will investigate nonverbal disclosure in boys between the ages of 6 through 10 using naturalistic observations …

Whither The Lofty Goals Of The Environmental Laws?: Can Statutory Directives Restore Purposivism When We Are All Textualists Now?, Stephen M. Johnson

Articles

Congress set ambitious goals to protect public health and the environment when it enacted the federal environmental laws through bipartisan efforts in the 1970s. For many years, the federal courts interpreted the environmental laws to carry out those enacted purposes. Over time, however, courts greatly reduced their focus on the environmental and public health purposes of the environmental laws when interpreting those statutes due to the rise in textualism, the declining influence of the Chevron doctrine, and the increasing willingness of courts to defer to agency underenforcement of statutory responsibilities across all regulatory statutes.

In 2020, the Environmental Protection Network, …

Extending Plasma Proteome Coverage To Enable Biomarker Discovery, Jordan Bruce Burton

Wayne State University Dissertations

Two features make plasma a valued source of health information: First, plasma contains secreted proteins from all tissues in the body and can, therefore, provide information about the health status of all tissues. Second, plasma is available in large quantity using a minimally invasive procedure that is well tolerated. The status of plasma as a valued source of health information is matched by the difficulty in extracting proteome information from the samples. Using state of the art instrumentation a standard analysis of plasma yields quantitative information on approximately 300 proteins. Extreme fractionation strategies coupled with increased mass spectrometry time extends …

Childhood Adversity And Alexithymia: Implications For Health Status In An Urban Police Sample, Christopher P. Urbanik

Wayne State University Dissertations

American law enforcement is regarded as one of the most stressful occupations in the United States, involving repeated exposure to threatening or challenging encounters and the risk of severe injury and death. A voluminous literature has documented various psychophysiological implications of police stress, including morbidity and premature mortality. Adverse childhood experiences (ACEs) are potentially traumatic stressors during one’s formative years, such as abuse, neglect, and household violence and dysfunction. ACEs have been linked to increased mental and physical health risks, yet ACEs have not been studied in police officers. Given the increase in the level of stress experienced by today’s …

The State Of The Art Of Information Integration In Space Applications, Zhuming Bi, K. L. Yung, Andrew W.H. Ip., Yuk Ming Tang, Chris W.J. Zhang, Li Da Xu

Information Technology & Decision Sciences Faculty Publications

This paper aims to present a comprehensive survey on information integration (II) in space informatics. With an ever-increasing scale and dynamics of complex space systems, II has become essential in dealing with the complexity, changes, dynamics, and uncertainties of space systems. The applications of space II (SII) require addressing some distinctive functional requirements (FRs) of heterogeneity, networking, communication, security, latency, and resilience; while limited works are available to examine recent advances of SII thoroughly. This survey helps to gain the understanding of the state of the art of SII in sense that (1) technical drivers for SII are discussed and …

Biom 4730 / Mech 4365: Biomaterials (Syllabus), Joel D. Bumgardner

Biomedical Engineering Syllabi Archive

Course Description: Synthetic materials and their interaction with the physiological environment; methods to design and study materials that are compatible with natural tissue.

Time Course Investigation Of The Dermal Leukocyte Response To Lipoteichoic Acid In Chickens, Ian M. Gilbert, Jossie M. Santamaria, Gisela F. Erf

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Lipoteichoic acid (LTA) is a cell-wall polymer in Gram-positive bacteria that stimulates inflammation. Few studies have investigated in vivo immune response to LTA, and none of the in vivo studies have been performed in birds. For this project, the pulp (a skin derivative) of growing feathers (GF) of chickens was used to investigate the in vivo effects of intradermally injected LTA. In Study 1, GF of chickens were injected with 10 μL of differing concentrations of LTA (0.1, 1.0, 10, 100 or 250 μg LTA/mL; 3 chickens/dose). Growing feathers were plucked before injection (0 h) and at 6, 24, 48, …

A Mini-Course On The Our Father/Lord's Prayer: Lecture Notes And Workshop And Discussion Topics [Lecture Notes], Scott Gambrill Sinclair

The Scott Sinclair Lecture Notes Collection

Lecture notes on a series of talks by Scott G. Sinclair's on his version of the Historical Jesus.

The Life, Teaching, Death, And Resurrection Of Jesus Of Nazareth And Some Implications [Lecture Notes], Scott Gambrill Sinclair

The Scott Sinclair Lecture Notes Collection

Lecture notes on a series of talks by Scott G. Sinclair's on his version of the Historical Jesus.

The Role Of Emotion In Constitutional Theory, J. Joel Alicea

Scholarly Articles

Although the role of emotion in law has become a major field of scholarship, there has been very little attention paid to the role of emotion in constitutional theory. This Article seeks to fill that gap by providing an integrated account of the role of emotion within the individual, how emotion affects constitutional culture, and how constitutional culture, properly understood, should affect our evaluation of major constitutional theories.

The Article begins by reconstructing one of the most important and influential accounts of emotion in the philosophical literature: that of Thomas Aquinas. Because Aquinas’s description of the nature of emotion accords …