Digital Commons Network^™

How Implicit Bias Contributes To Racial Disparities In Maternal Health, Michaella Saintil

Honors Undergraduate Theses

A rise in racial disparities in maternal health has become an ongoing issue in the United States. This study uses a scoping literature review method to examine the effect of implicit bias on racial disparities in maternal healthcare. Multiple articles in this study provide sufficient evidence to prove that implicit bias is a contributing factor to the alarming rise of racial disparities in maternal health outcomes. The study revealed two distinct categories that elaborate on the health crisis that has been a continuation of practices traced backed to slavery. The analysis for this research is grounded in lack of quality …

Removal Of Emerging Contaminants From Wastewater Streams Using Membrane Bioreactors: A Review, Arijit Sengupta, Mahmood Jebur, Mohanad Kamaz, Sumith R. Wickramasinghe

Chemical Engineering Faculty Publications and Presentations

Water is a very valuable natural resource. As the demand for water increases the presence of emerging contaminants in wastewater has become a growing concern. This is particularly true when one considers direct reuse of wastewater. Obtaining sufficient removal of emerging contaminants will require determining the level of removal for the various unit operations in the wastewater treatment process. Membrane bioreactors are attractive as they combine an activated sludge process with a membrane separation step. They are frequently used in a wastewater treatment process and can operate at higher solid loadings than conventional activated sludge processes. Determining the level of …

Recent Strategies For Using Monolithic Materials In Glycoprotein And Glycopeptide Analysis, Allan Alla, Keith Stine

Chemistry & Biochemistry Faculty Works

There is continuous effort towards developing monolithic materials as solid supports for the separation, enrichment, and digestion of glycoproteins. The intention of this review is to discuss and summarize work reported in this area during the period 2015–2021 as a follow-up to our prior review. Reports from the past three decades have already proven the advantages of monolithic materials, such as the ease with which they can be prepared and functionalized, their high permeability and low resistance to mass transfer, and their stability over a wide range of pH. Recent works on glycoprotein analysis introduce different strategies in using monolithic …

Comparison Of Effects Of Sleep Fragmentation On Pro-Inflammatory Cytokine Il-1Β Of Male And Female Adult Mice, Manzar Rzayeva

Mahurin Honors College Capstone Experience/Thesis Projects

Sleep plays an essential role throughout the body by affecting the physiological function and regulation of many systems. One of these systems that receives effects as a result of the adequacy of sleep is the immune system. Previous studies have demonstrated effects of sleep fragmentation upon the immune system; however, sexual differences of these effects have not been studied in depth. To analyze these variances amongst the genders, male and female adult mice were subjected to acute sleep fragmentation (SF) for 24 hours in an automated SF cage that includes a bar sweeping across the cage every two minutes. Meanwhile, …

Antitype: An Exploration Of Self And Poetry, Faith Harris

Mahurin Honors College Capstone Experience/Thesis Projects

Antitype is a collection of poetry that examines childhood and adolescence through a lens of place and loss, while exploring both poetry and creative processes. The work presented begins by contextualizing antitype within the history of poetry, assessing influences of specific poets and poetic movements on my own work. Next, I share excerpts from my poetry collection to illustrate connections from its five different sections, each investigating facets of this overarching theme: my childhood affected by loss and as it contributes to my development as a poet. Section one examines how my childhood was shaped by place and family heritage. …

The Role Of Dichloro(Ethylenediamine) Platinum Ii In Altering Cellular Iron And Copper Transport, Megan Hall

Mahurin Honors College Capstone Experience/Thesis Projects

Approximately 50% of all chemotherapy cancer patients receive a platinum chemotherapeutic during their treatment. Although these drugs are widely utilized, little is known about the cellular transport of platinum drugs. It is hypothesized that platinum utilizes transporters for other metals to enter the cell. Structural differences between compounds are predicted to affect the compounds’ ability to exploit different transporters. Also, different cell types express different transporters. Therefore, compound structure is expected to influence transport of platinum compounds differently in different cell types. This study investigated the role of the platinum drug cisplatin and platinum compound Pt(en)Cl₂ in altering iron …

Crossmodal Perception Of Object Shape: A Study On The Effect Of Modal Order On Successful Shape Recognition, Ashlyn Vale

Mahurin Honors College Capstone Experience/Thesis Projects

Visual and haptic (tactile) modes of perception, while occasionally exercised independently, most often occur concurrently. The degree to which the ordering of the two modes of perception affects successful recognition of three-dimensional shapes varies. Some have found that the cross-modal orders (vision followed by haptics or vice versa) produce equal performance (Caviness, 1964; Lacey, Peters, & Sathian, 2007; Norman et al., 2006), while other researchers found visual-haptic (VH) performance to be superior to haptic-visual (HV) performance (Davidson, Abbott, & Gershenfeld, 1974; Norman, Clayton, Norman, & Crabtree, 2008). The current experiment used an old-new recognition task (with cookie cutter stimuli). In …

Kids, Culture, And Queerness: The Progression Of Lgbtq+ Representation In Children's Media, Sarah Stevens

Mahurin Honors College Capstone Experience/Thesis Projects

Historically, popular media has functioned as a window into society’s ever evolving idea of normalcy. Children’s popular media, which contains elements of both entertainment and didacticism, is further burdened with the responsibility of influencing the perspectives of upcoming generations. This truth is particularly salient for the LGBTQ+ community, who have faced consistent misrepresentation or utter erasure from children’s media in the recent past. While there have been marked improvements in both the quality and quantity of queer representation in children’s media since 2015’s Obergefell v. Hodges case, there is still a significant need to acknowledge intersectional queerness and queer gender …

A Pilot Study: An Evaluation Of Accessibility Of Resources For Parents Of D/Deaf/Hoh Children In Ky/Tn, Amara Danturthi

Mahurin Honors College Capstone Experience/Thesis Projects

Most parents of d/Deaf/Hoh children are not Deaf, making it imperative for easy access to diverse strategies to ensure smooth communication between them and their child. Parents make the paramount decision of what their child’s first language should be, therefore, access to current information on communication strategies is crucial in this journey. Many families fall on resources sometimes from sources in different formats to understand what may work best for them. The accessibility and availability of these resources are a crucial component in the parent’s decision-making process. Due to the unique dynamics between hearing parents and d/Deaf/Hoh children, this pilot …

Three Waves: The United States Opioid Crisis, Ryan B. Santoro

Senior Scholars Papers in Science, Technology, and Society

The past two and a half decades have witnessed widespread suffering, addiction, and death at the hands of the opioid crisis. This paper analyzes the crisis through a series of time periods, broken down into “waves.” Drawing upon primary material in relation to OxyContin advertisements in the 1990’s, this research takes aim at the origin of widespread opioid abuse disorder. By building upon analysis done on the Sackler Family, Purdue Pharma, heroin abuse, fentanyl overdoses, the COVID-19 pandemic and opioids and addiction in modern pop culture, this thesis shows how despite constant change in public policy, the opioid crisis continues …

Soil Health And The Effects Of Nanoparticles, Elijah Mock

Natural Sciences Student Research Presentations

I researched the effects of soil on human health. Specifically, I was interested in nanoparticles that reside in soil and how they affect humans as well as crops that are planted in the soil. This topic is relevant because nanoparticles can be used to deliver drugs for doctors, create specific properties for material scientists, sensors for the military, and in a plethora of other fields (“What Are Nanoparticles? Definition, Size, Uses and Properties.”).

Root Phenotyping Of Peptide-Treated Glycine Max, Salem Jackson, Fiona Goggin

Inquiry: The University of Arkansas Undergraduate Research Journal

Plant elicitor peptides (Peps) – endogenous chains of amino acids involved in natural plant defense – have been shown to decrease damage from herbivores and pathogens by inducing an immune response, increasing the emission of volatile organic compounds (VOCS), transcripts, and metabolites. Exogenous treatment of soybean seeds with plant elicitor peptide GmPep3 has been shown to induce these broad-spectrum defenses and offers a new method for increasing crop yield. However, the effects of GmPep3 on indicators of soybean health – root characteristics, growth stages, etc. – have not been fully realized. Using the root-phenotyping platform RhizoVision Explorer, several root traits …

Faculty Highlights, Inquiry Editors

Inquiry: The University of Arkansas Undergraduate Research Journal

No abstract provided.

Perceived Self-Efficacy, Confidence, And Skill Among Factors Of Adult Patient Participation In Transitional Care: A Systematic Review Of Quantitative Studies., Andrea Bailey, Jennifer Mallow, Laurie A. Theeke

Nursing Faculty Publications

Introduction: An advancing healthcare system in which patients are often required to self-manage care needs across countless settings and clinicians is increasing focus on participation in care. Mismanagement of care during already risky care-transitions further increases adverse care outcomes. Understanding factors of patient participation in transitional care in an adult population can help guide ways to reduce this burden.

Methods: A systematic review of the literature guided by the PRISMA method was conducted to identify factors of patient participation in transitional care. Quantitative studies in which patient participation was measured as an outcome variable and related statistics reported, and data …

Archives Of Neurosurgery Volume 1 Issue 2 - Full Issue

Archives of Neurosurgery

Archives of Neurosurgery Volume 1 Issue 2 - Full Issue

A Home Shielded By Laws: Freedom Suits And Enslaved Mothers, Heidi Martin

Digital Legal Research Lab

This project collects, digitizes, and makes accessible the freedom suits brought by enslaved families in the Circuit Court for the District of Columbia, Maryland state courts, and the United States Supreme Court. This project places families in the foreground of our interpretive framework of slavery and national formation.

Using TEI encoding, we focused on outcomes, relationships between individuals and the claim for freedom made. Using these data sets, I focused specefically on mothers petitioning for their children. Of the 508 cases I utilized, 131 included children and a parental figure. I set out to distinguish the additional burden mothers had …

Implementation Of An Icu Surge Capacity Response Protocol, Patrick Simon Soria

Regis University Student Publications (comprehensive collection)

Implementation of an ICU Surge Capacity Response Protocol

Patrick Simon S. Soria

Abstract

High consequence infectious diseases (HCID) threaten healthcare systems because of their high transmissibility, resulting in massive infections within hours. In the initial stages of an HCID outbreak in developing countries, there are no definite treatment pathways and guidelines to manage patients who become critically ill. The prolonged surge of critically ill patients affects the physical and mental well-being of intensive care unit (ICU) nurses due to many factors. An ICU surge capacity response protocol was implemented in four intensive care units for four months at one government …

Counseling Children And Adolescents: A Call To Action, Rebekah Byrd, Chad Luke, Sonya Lorelle, Emily Donald, Charmayne R. Adams, Edward (Franc) Hudspeth

Office of Health Promotion Scholarship

The ACA 2014 Code of Ethics clearly states the mandate for counselor competence in C.2.a. It is noted that “Counselor practice only within the boundaries of their competence, based on their education, training, supervised experience, state and national credentials, and appropriate professional experience” (p. 8). Given the importance of competencies, ethical standards, and the emphasis on best practice, the paucity of these factors in regard to training and supervision for counselors working with child and adolescent populations is concerning. This article offers a conceptualization of the culture of childhood leading to the need for cultural competency. It outlines information specific …

Investigating Replacement Of A Yeast Gene With A Human Gene As A Rare Disease Model System, Emma Pastoor, Amy Wilstermann, Rachael Baker

Summer Research

• BCS1L is a mitochondrial protein that assists in building complex III of the electron transport chain which allows for cellular respiration to occur
• Different mutations in BCS1L can result in three rare genetic diseases: Bjornstad Syndrome, BCS1L Mitopathy, or GRACILE Syndrome

Gender Differences In Outcomes Of Coordinated Specialty Care For Early Psychosis, Seong Im Hong

Yale Medicine Thesis Digital Library

BACKGROUNDThere has been growing interest in early intervention in psychotic disorders. However, gender differences in the outcomes of treatment have not been \studied in a clinical trial.

METHODSPatients diagnosed with schizophrenia or schizoaffective disorder with less than 6 months exposure to antipsychotics entered a cluster randomized trial of coordinated specialty care in the Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP). Secondary analyses examined gender differences in baseline characteristics as well as two-year gender outcomes, and the response to treatment controlling for baseline differences. Blinded evaluators assessed the Quality of Life Scale and the Positive and Negative Syndrome …

Impact Of Single-Family-Room Nicu Design On Infant Neurodevelopment And Breast Milk Provision, Lucille Kohlenberg

Yale Medicine Thesis Digital Library

NEONATAL INTENSIVE CARE UNIT DESIGN IMPACTING INFANT OUTCOMES AND BREAST MILK PROVISION.

Lucille Kohlenberg and Angela Montgomery, MD, MSEd. Section of Neonatal-Perinatal Medicine, Department of Pediatrics, Yale School of Medicine. New Haven, CT.

Single-family room (SFR) NICUs have gradually replaced open-bay (OB) units over the last three decades. Compared to OB units, SFR units provide increased opportunities for parental rooming and maternal breast milk (MBM) provision; however, they may also present fewer sensory exposures and parental learning opportunities. Due to the presence of potentially beneficial and detrimental effects, it remains uncertain whether the SFR design offers aggregate advantages over the …

2002 - 2022 Senior Thesis Projects, Honors College

2002-2022 Senior Thesis Projects Index

This is a compilation of the Senior Thesis projects completed from 2002 through 2022 in the Honors College, formerly known as the University Honors Program. The contents include thesis projects by year of student graduation, an index by major, an index by mentor, and an alphabetical index by student author.

Icipe Annual Report 2022, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Annual Reports

No abstract provided.

Proteome Database, Mariana Rius, Jackie L. Collier, Joshua Rest

SoMAS Research Data

No abstract provided.

2022-2023 - Etsu General Academic Analysis Tables (October), Budget And Financial Planning, East Tennessee State University

ETSU General Academic Operating Budgets and Analysis

No abstract provided.

2022-2023 - Etsu General Academic Analysis Tables (July), Budget And Financial Planning, East Tennessee State University

ETSU General Academic Operating Budgets and Analysis

No abstract provided.

Relationships Of Serum Cc16 Levels With Smoking Status And Lung Function In Copd, Kelli C. Gribben, Jill A. Poole, Amy J. Nelson, Paraskevi A. Farazi, Christopher S. Wichman, Art J. Heires, Debra J. Romberger, Tricia D. Levan

Journal Articles: Pulmonary & Critical Care Med

Background: The club cell secretory protein (CC16) has anti-inflammatory and antioxidant effects, and low CC16 serum levels have been associated with both risk and progression of COPD, yet the interaction between smoking and CC16 on lung function outcomes remains unknown.

Methods: Utilizing cross-sectional data on United States veterans, CC16 serum concentrations were measured by ELISA and log transformed for analyses. Spirometry was conducted and COPD status was defined by post-bronchodilator FEV₁/FVC ratio < 0.7. Smoking measures were self-reported on questionnaire. Multivariable logistic and linear regression were employed to examine associations between CC16 levels and COPD, and lung function with adjustment for covariates. Unadjusted Pearson correlations described relationships between CC16 level and lung function measures, pack-years smoked, and years since smoking cessation.

Results: The study population (N = 351) was mostly male, white, with an average age over 60 years. An interaction between CC16 and smoking status on …

Updated Perspectives On The Role Of Biomechanics In Copd: Considerations For The Clinician, Jennifer M. Yentes, Wai-Yan Liu, Kuan Zhang, Eric Markvicka, Stephen I. Rennard

Journal Articles: Pulmonary & Critical Care Med

Patients with chronic obstructive pulmonary disease (COPD) demonstrate extra-pulmonary functional decline such as an increased prevalence of falls. Biomechanics offers insight into functional decline by examining mechanics of abnormal movement patterns. This review discusses biomechanics of functional outcomes, muscle mechanics, and breathing mechanics in patients with COPD as well as future directions and clinical perspectives. Patients with COPD demonstrate changes in their postural sway during quiet standing compared to controls, and these deficits are exacerbated when sensory information (eg, eyes closed) is manipulated. If standing balance is disrupted with a perturbation, patients with COPD are slower to return to baseline …

An Artifact In Intracellular Cytokine Staining For Studying T Cell Responses And Its Alleviation., Zheng Gong, Qing Li, Jiayuan Shi, Guangwen Ren

Faculty Research 2022

Intracellular cytokine staining (ICS) is a widely employed ex vivo method for quantitative determination of the activation status of immune cells, most often applied to T cells. ICS test samples are commonly prepared from animal or human tissues as unpurified cell mixtures, and cell-specific cytokine signals are subsequently discriminated by gating strategies using flow cytometry. Here, we show that when ICS samples contain Ly6G⁺ neutrophils, neutrophils are ex vivo activated by an ICS reagent - phorbol myristate acetate (PMA) - which leads to hydrogen peroxide (H₂O₂) release and death of cytokine-expressing T cells. This artifact …

Curation And Expansion Of Human Phenotype Ontology For Defined Groups Of Inborn Errors Of Immunity., Matthias Haimel, Julia Pazmandi, Raúl Jiménez Heredia, Jasmin Dmytrus, Sevgi Köstel Bal, Samaneh Zoghi, Paul Van Daele, Tracy A Briggs, Carine Wouters, Brigitte Bader-Meunier, Florence A Aeschlimann, Roberta Caorsi, Despina Eleftheriou, Esther Hoppenreijs, Elisabeth Salzer, Shahrzad Bakhtiar, Beata Derfalvi, Francesco Saettini, Maaike A A Kusters, Reem Elfeky, Johannes Trück, Jacques G Rivière, Mirjam Van Der Burg, Marco Gattorno, Markus G Seidel, Siobhan Burns, Klaus Warnatz, Fabian Hauck, Paul Brogan, Kimberly C Gilmour, Catharina Schuetz, Anna Simon, Christoph Bock, Sophie Hambleton, Esther De Vries, Peter N Robinson, Marielle Van Gijn, Kaan Boztug

Faculty Research 2022

BACKGROUND: Accurate, detailed, and standardized phenotypic descriptions are essential to support diagnostic interpretation of genetic variants and to discover new diseases. The Human Phenotype Ontology (HPO), extensively used in rare disease research, provides a rich collection of vocabulary with standardized phenotypic descriptions in a hierarchical structure. However, to date, the use of HPO has not yet been widely implemented in the field of inborn errors of immunity (IEIs), mainly due to a lack of comprehensive IEI-related terms.

OBJECTIVES: We sought to systematically review available terms in HPO for the depiction of IEIs, to expand HPO, yielding more comprehensive sets of …