Digital Commons Network^™

The Role Of Integrins In Hiv-1 Infection Of Intestinal Endothelial Cell Stimulated Resting Cd4+ T Cells, Jessica Eddy, Fisher Pham, Nathan Dapprich, Anding Shen

Summer Research

A major barrier to eradicating HIV is latent reservoirs in resting CD4+ T cells. Antiretroviral therapy is effective in bringing the viral load down to undetectable levels but is unable to eradicate the latent reservoir. Previous data from our lab revealed that when stimulated by intestinal endothelial cells (IEC), resting CD4+ T cells can be directly infected while remaining in a resting state, allowing formation of latent reservoirs. An additional study found that integrins, which are cell surface molecules, play a role in the interactions between endothelial cells (EC) and T cells. Our research further examines the role of integrins …

A Tale Of Two Toxicants: How Trichloroethylene (Tce) And Perchloroethylene (Pce) Metabolites Affect Immune Cell Viability Upon Co-Exposure With Lipopolysaccharide (Lps), Eleanor Scheeres, Sean Harris, Erica Boldenow

Summer Research

• TCE and PCE are volatile organic solvents used in industrial processes, such as metal degreasing and dry cleaning, and known human carcinogens.
• GBS is a common bacteria in the vaginal flora but can lead to complications such as preterm birth during pregnancy.
• Lipopolysaccharide (LPS) is a gram-negative bacterial cell wall component that induces inflammatory immune responses and is used as an infection model.
• Co-treatment (GBS+DCVC) in placental membranes lead to inhibition of pathogen stimulated cytokine secretion (Fig. 1).
• We hypothesized that DCVC and TCVC (PCE’s metabolite) would produce decreased cell viability, and DCVC+LPS would produce further immune inhibitory effects, which …

Comparing Plant Diversity In Native Landscaping At Calvin University, Rine Wakeman, Dave Warners

Summer Research

Calvin University is home to several naturally planted sites, including woodland areas, three rain gardens, and several landscaping beds. The plants that populate these areas are native to Calvin’s watershed and West Michigan. Until this year, no database existed to keep track of which species of plants grow on campus and where. Over the summer, native sites on campus were surveyed to compile a database of the unique species found to examine the capacity for non-human, non-plant diversity on campus. How does the diversity of native sites compare to traditionally planted sites of similar size or position on Calvin University's …

Er-Golgi In Membrane Repair In Cardiomyocytes, Visakuo Tsurho, Hsin-Yu Chen, Daniel Michele

Summer Research

Impaired membrane repair leads to muscular dystrophies like Miyoshi Myopathy and LGMD2B1. The mechanism behind membrane repair is not well understood, and there are few studies on membrane repair in cardiomyocytes. Research in nonmuscle cells suggest that lysosomes are a source of membranes for repairing injuries2. Few lysosomes were found in cardiomyocytes compared to non cardiomyocytes. Therefore, we investigated the ER and Golgi as potential organelles involved in membrane repair in cardiomyocytes. We used Sec22b to investigate ER to Golgi in membrane repair in cardiomyocytes because it is an ER-Golgi protein involved in membrane fusion and Golgi vesicle trafficking in …

Floodplain Monitoring – Plaster Creek Segment At Shadyside Park, Alin Stoica, Julie Wildschut

Summer Research

• High stream velocity and flow rate during precipitation events endanger the urban areas through bank erosion and potential of flooding due to steep entrenchment of streambeds. An urban creek, Plaster Creek was impacted by this phenomenon throughout its watershed.
• Plaster Creek Stewards restored the segment of Plaster Creek located within Dutton Shadyside Park, Mi in 2018 by receding the walls of the tall banks that were entrenching the stream.
• The restored floodplains provide improved distribution of overflow water onto the plain, lowering bank erosion and sediment transportation. Native riparian vegetation planted along the plain improves biodiversity, strengthening the creek banks, …

Urinformed Summer 2022, Urinformed

URInformed: The URI Employees' Newsletter

No abstract provided.

Transforming Social Determinants To Educational Outcomes: Geospatial Considerations, Gary Szirony, S Banerjee, Mccune, Davis

Walden Faculty and Staff Publications

No abstract provided.

The Family History Of Parker Weddle, Parker Weddle

Your Family in History: HIST 550/700

The Family History of

Parker G. Weddle

27 November 2022

Parker Weddle has authored this family history as part of the course requirements for HIST 550 Your Family in History offered online in Fall 2022 and was submitted to the Pittsburg State Uni-versity Digital Commons. Please contact the author directly with any questions or comments: [email protected]

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Prevalence And Characterization Of Antibiotic Resistant Strains Of Enterococcus Spp. And Acinetobacter Spp. In Community Household Environment, Niamh Dixon, Madison Reese, Monika Jirak, Alex Tush, Anuradha Ghosh

Posters

With increasing prevalence of antibiotic resistance threats, there is an upsurge in the occurrence of community-acquired infections. The purpose of this study is to assess the ecology and prevalence of Enterococcus spp. and Acinetobacter spp. (that are well-known antibiotic resistant nosocomial pathogens) in the household environment. Each household sampling kit contained 5 swabs for each of shoe bottom, restroom, cleaning supply, kitchen top, and door step/handle as well as a demographic data sheet to be filled up. A total of 30 such kits (n=150) have been processed. The swabs were subjected to enrichment using selective media for test bacterial species. …

Human Dimensions Survey Of Park Visitors At The Southeast Kansas Nature Center, Isabelle Villafañe, Austin Abram, John Jameson, Christine Brodsky

Posters

The management of our natural resources is often a complex task, as many actions have direct or indirect human consequences. Not only do natural resource managers have to evaluate species’ needs and the quality and availability of habitats, the human dimension of the resource needs to be integrated into planning and management efforts. As our society becomes more diverse, natural resource agencies should understand stakeholder values and behaviors in order to manage the resource in an informed, adaptive manner. In collaboration with the Kansas Department of Wildlife, and Parks (KDWP), we developed a survey to assess the demographics and environmental …

In The Danger Zone: The Call For Reshoring Pharmaceutical Manufacturing To Reduce The Vulnerability Of The United States' Supply Chains To War Tactics, Jessica K. Andrews

Florida State University Journal of Transnational Law & Policy

No abstract provided.

Metabolomic Analysis Of Trypanosoma Congolense And Leishmania Mexicana Treated With Selected Antiparasitic Drugs And In Silico Modelling Of Potential Drug Targets, Laurah Nyasita Ondari

All Master’s Theses

Animal African Trypanosomiasis (AAT) is a devastating parasitic disease caused by a variety of haemoflagellate extracellular protozoa of the genus Trypanosoma. It is endemic in 37 of the 55 countries in Africa and is transmitted by the obligate blood feeder of the genus Glossina. It affects both domestic and wild animals causing huge economic losses and severe health problems. Chemotherapeutic and prophylactic agents such as Isometamidium chloride (ISM) are used to prevent the progression of AAT in endemic areas. These agents face limitations such as resistance, toxicity, low efficacy, and unknown mechanisms of action. Therefore, it is crucial to develop …

Western Australian Sea Cucumber Resource Assessment Report, A.M. Hart, D.M. Murphy, F.F. Fabris

Fisheries Research Reports

No abstract provided.

How The Physical Long-Haul Symptoms Of Covid-19 Influence Occupational Performance From A Person-Environment-Occupation Perspective: A Critically Appraised Topic, Emmalee Burtsfield, Amber Matlock, Alyssia Pucel

Critically Appraised Topics

An increasing number of adults continue to experience the long-term physical effects of COVID-19. Currently, there is uncertainty regarding the best practices in occupational therapy to address long-haul COVID-19 symptomology and its effects on people as research on the topic continues to emerge (Robinson et al., 2021). The purpose of this critically appraised paper is to identify prominent areas on which occupational therapists should focus during evaluation and intervention planning while considering the person, environment, and occupation to encompass the ideals of best practice when working with adult clients who are facing disruptions as a result of long-haul COVID-19 symptoms.

Environmental Sciences Doctoral Degree Annual Program Outcomes Assessments, 2021-22, College Of Science And Mathematics, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Environmental Sciences Doctoral Degree program for the 2021-2022 academic year.

Biological Sciences, B.A. Baccalaureate Degree Annual Program Outcomes Assessments, 2021-22, College Of Science And Mathematics, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Biological Sciences, B.A. Baccalaureate Degree program for the 2021-2022 academic year.

Clinical Psychology Doctoral Degree Annual Program Outcomes Assessments, 2021-22, College Of Health, Education, And Human Services, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Clinical Psychology Doctoral Degree program for the 2021-2022 academic year.

Parenting, Neighborhood Characteristics, And Disruptive Child Behavior In Low-Income African American Families, Alyssa Buthman

Master's Theses and Doctoral Dissertations

The purpose of this study is to further examine the multifaceted relationship between parenting, neighborhood characteristics, and child disruptive behavior. Examining data from a low-income, African American preschool sample, this study investigated how self-reported neighborhood characteristics and observed parenting behaviors uniquely predicted observed disruptive behavior in children. Findings supported the strong relationship between parenting behaviors and child disruptive behavior where parenting sensitivity and engagement were predictive of fewer child disruptive behaviors while verbal and physical parenting interference and intrusiveness was predictive of greater disruptive child behavior. Neighborhood characteristics did not directly relate to parenting or child behaviors. However, neighborhood characteristics …

Characterization Of Cofilin And Its Potential Role In The Epha4 Pathway, Brian Donald Condron

Master's Theses and Doctoral Dissertations

EphA4 is a receptor tyrosine kinase that is responsible for cellular adhesion and locomotion using repulsion signaling in early development of Xenopus laevis. EphA4 regulates cellular locomotion by controlling proteins within its signal transduction pathway, which may include the protein cofilin. Cofilin actively severs and removes actin monomers, thus altering the actin cytoskeleton, leading to the cessation of cellular crawl. During the gastrulation phase of embryonic development, individual cells are relocating to create the three primary germ layers of the organism. Failure of this process to occur results in attrition of the embryos, frequently by way of embryonic exogastrulation. …

Influence Of Social Cues On The Initiation Of Migratory Behavior In Red Crossbills (Loxia Curvirostra), John Bobo

Master's Theses and Doctoral Dissertations

The timing of migration is crucial for the fitness of organisms because mistimed migration can cause exposure to difficult conditions. Photoperiod drives migratory timing in many species, but little work has focused on how social cues might fine-tune migratory timing. The goal of this study is to determine if birds use social cues from conspecifics to fine-tune the initiation of migratory behavior and physiology. Red crossbills (Loxia curvirostra) are gregarious, nomadic migrants that make seasonal movements to find patchily-distributed conifer seeds and are responsive to social cues in the context of food. I test the hypothesis that social …

Catalytic Enantioselective Birch–Heck Sequence For The Synthesis Of Phenanthridinone Derivatives With An All-Carbon Quaternary Stereocenter, Mary Elizabeth Sexton, William Paul Malachowski, Glenn P. A. Yap, Diana Rachii, Greg Feldman, Andrew T. Krasley, Zhilin Chen, My Anh Tran, Kalyn Wiley, Alexandra Matei, Samantha Petersen, Sabrina Tran Tien

Chemistry Faculty Research and Scholarship

Novel phenanthridinone analogues with an all-carbon quaternary stereocenter have been enantioselectively synthesized using the Birch–Heck sequence. Flat phenanthridinone structures have extensive bioactivity but consequently also suffer from poor therapeutic selectivity. The addition of a quaternary center to the phenanthridinone skeleton has the potential to generate more complex analogues with improved selectivity. Unfortunately, no general synthetic pathway to such derivatives exists. Herein we report a four-step process that transforms inexpensive benzoic acid into 22 different quaternary carbon-containing phenanthridinone analogues with a variety of substituents on all three rings: alkyl groups at the quaternary center; methyl, methoxymethyl, or para-methoxybenzyl on the …

Quantitative Sustainable Design (Qsd) For The Prioritization Of Research, Development, And Deployment Of Technologies: A Tutorial And Review, Yalin Li, John T. Trimmer, Steven Hand, Xinyi Zhang, Katherine G. Chambers, Hannah A. C. Lohman, Rui Shi, Diana M. Byrne, Sherri M. Cook, Jeremy S. Guest

UK CARES Faculty Publications

The pursuit of sustainability has catalyzed broad investment in the research, development, and deployment (RD&D) of innovative water, sanitation, and resource recovery technologies, yet the lack of transparent and agile methodologies to navigate the expansive landscape of technology development pathways remains a critical challenge. This challenge is further complicated by the higher levels of uncertainty that are intrinsic to early-stage technologies. In this work, we review and synthesize published literature on the sustainability analyses of water and related technologies to present quantitative sustainable design (QSD) – a methodology to expedite and support technology RD&D. With a shared lexicon and a …

Family Participatory Research Practices: A Reflection, Serena Troiani

Publications and Research

This column discusses the importance of family participatory research practices with particular regard for vulnerable populations and alternative learning opportunities and the need for an expanded approach to the use of multimodalities in the classroom. The author reflects upon her experience as she conducted her dissertation, a case study with her nephew, an adolescent diagnosed with autism, exploring his use of multimodalities as an expressive practice, and to see how they informed his meaning making. The column addresses the author’s various roles and positionality and how the author’s use of a reflexive journal provided a space to document any ethical …

Electrophysiological Responses To Conspecific Odorants In Xenopus Laevis Show Potential For Chemical Signaling, Heather J. Rhodes, Melanie Amo

Faculty Publications

No abstract provided.

The Relationship Between Head And Neck Lymphedema And Dysphagia For Individuals With Oropharyngeal Cancer: A Retrospective Study, Madison A. Cherry

OT Student Capstones

The American Cancer Society (2022) estimates about 54,000 new cases of oropharyngeal cancer in 2022. Oropharyngeal cancer, a type of head and neck cancer (HNC), typically refers to cancer in the base of tongue, oropharynx, tonsils, or mouth. The American Cancer Society (as cited by Cohen et al., 2016) recommends that physicians assess HNC survivors for lymphedema and refer them to a lymphedema therapist if necessary. Lymphedema presents as soft-tissue swelling and localized accumulation of high-protein fluid that can cause an inflammatory response resulting in disfigurement, tissue fibrosis, functional limitation, pain, and infections (Gutiérrez et al., 2020). There are two …

Establishing Test-Retest Reliability And Internal Consistency Of The Occupational Resilience Measure, Kara Gore

OT Student Capstones

Without a clear understanding of the dynamic relationship between resilience and occupation, occupational therapy has lacked the tools necessary to optimize resilience in research and clinical practice.

Occupational resilience is defined as “the capacity for persistence in the performance of an occupation, whereby capacity is reflected in both duration and intensity of engagement in a specified occupation” (Muriithi et al., 2022).

Occupational Resilience Measure 1.0 (ORM) and the Occupational Resilience Individual Perception Scale (ORIPS) to be used as the primary assessment tools for measuring resilience in individual occupations.

Aim: Establish the test-retest reliability and internal consistency of the ORM; establish …

Fostering Healthy Therapeutic Relationships: Foster Parent Education Program, Sydnie Barboza

OT Student Capstones

Background: Children who have been placed in the foster care system due to trauma often have difficulty coping with past experiences. These traumatic experiences can often affect their development, physically and mentally, and emotional regulation, relationships, and attachment. As of April 2021, more than 13,400 children were placed in the foster care system in Arizona. While removing children from their birth home to a safer environment is critical, it brings along many challenges such as emotional trauma and inconsistent caregiving. Methods: The foster parent educational program described in this paper, “Fostering Healthy Therapeutic Relationships,” is a foster and adoptive parent …

“All I Want Is To Be Free”, University Of Chicago Law School - Global Human Rights Clinic

Global Human Rights Clinic

Statelessness — the condition of lacking citizenship or nationality in any country of the world — affects more than 10 million people globally. In the United States, conservative estimates put the number of stateless persons at over 200,000. Given that the U.S. provides citizenship to people born on the territory, nearly all stateless persons within the U.S. were born elsewhere. However, the U.S. immigration framework is silent with respect to statelessness, in effect leaving stateless people unrecognized, unprotected and invisible before the law.

As persons relegated to a life without legal status, stateless people in the United States are subject …

Discovery Of New 1h-Pyrazolo[3,4-D]Pyrimidine Derivatives As Anticancer Agents Targeting EgfrWt And EgfrT790m, Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Hanan Gaber Abdulwahab

Faculty and Student Publications

New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds 8, 10, 12a, and 12b showed potent anti-proliferative activities. Compound 12b was the most promising member with IC50 values of 8.21 and 19.56 µM against A549 and HCT-116, respectively. Compounds 8, 10, 12a, and 12b were evaluated for their kinase inhibitory activities against wild EGFR (EGFRWT). Compound 12b was the most potent member showing an IC50 value of 0.016 µM. In addition, compound 12b showed noticeable …

Influence Of Extracellular Volume Fraction On Peak Exercise Oxygen Pulse Following Thoracic Radiotherapy, Justin M. Canada, Elisabeth Weiss, John D. Grizzard, Cory R. Trankle, Leila Rezai Gharai, Franklin Dana, Leo F. Buckley, Salvatore Carbone, Dinesh Kadariya, Anthony Ricco, Jennifer H. Jordan, Ronald K. Evans, Ryan S. Garten, Benjamin W. Van Tassell, W. Gregory Hundley, Antonio Abbate

Internal Medicine Publications

Background

Radiation-induced myocardial fibrosis increases heart failure (HF) risk and is associated with a restrictive cardiomyopathy phenotype. The myocardial extracellular volume fraction (ECVF) using contrast-enhanced cardiac magnetic resonance (CMR) quantifies the extent of fibrosis which, in severe cases, results in a noncompliant left ventricle (LV) with an inability to augment exercise stroke volume (SV). The peak exercise oxygen pulse (O2Pulse), a noninvasive surrogate for exercise SV, may provide mechanistic insight into cardiac reserve. The relationship between LV ECVF and O2Pulse following thoracic radiotherapy has not been explored.

Methods

Patients who underwent thoracic radiotherapy for chest malignancies with significant incidental heart …