Digital Commons Network^™

Double-Stage Shrinkage Estimation Of Reliability Function Forburr Xii Distribution, Iman Jalil Atewi, Alaa Khlaif Jiheel, Ashok Ramdas Rao Shanubhogue

Iraqi Journal for Computer Science and Mathematics

This study is concerned with the problem of estimating the reliability function of the parameters of thetwo-parameter Burr XII distribution when the data are complete. Concepts such as the likelihood estimator, bias, biasratio, and mean square error are defined. The purpose of this research is investigate the properties of the double-stageshrinkage estimators (DSSEs) of the reliability function of Burr XII distribution and obtain the equations of bias,mean square error, and bias ratio. The relative efficiency of the Burr XII distribution of the proposed estimators isalso investigated by deriving their equations. Numerical results show performance of our estimators to be better …

Into The Deep: Navigating From Loneliness To Infinity, Joseph Wong Shun Yip

Loyola Papers

No abstract provided.

Emory-Tibet Science Initiative: Changes In Monastic Science Learning Motivation And Engagement During A Six-Year Curriculum, Kelsey M. Gray, Cindy Achat-Mendes, Ann Cale Kruger, Tashi Lhamo, Rinchen Wangyal, Gelek Gyatso, Carol M. Worthman

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Led by His Holiness the Dalai Lama, the initiative taken by the Tibetan Buddhist monastic community to connect with western science and scientists presents a unique opportunity to understand the motivations and engagement behaviors that contribute to monastic science learning. In this study, we draw on quantitative data from two distinct surveys that track motivations and engagement behaviors related to science education among monastic students. The first survey was administered at one monastic university in 2018, and the second follow-up survey was completed by students at two monastic universities in 2019. These surveys assessed the reception of science education related …

Gene Expression Analysis Via Spatial Clustering And Evaluationindexing, Awrad D. Salman

Iraqi Journal for Computer Science and Mathematics

The density-based spatial clustering for applications with noise (DBSCAN) is one of the most popularapplications of clustering in data mining, and it is used to identify useful patterns and interesting distributions in theunderlying data. Aggregation methods for classifying nonlinear aggregated data. In particular, DNA methylations,gene expression. That show the differentially skewed by distance sites and grouped nonlinearly by cancer daisiesand the change Situations for gene excretion on it. Under these conditions, DBSCAN is expected to have a desirableclustering feature i that can be used to show the results of the changes. This research reviews the DBSCAN andcompares its performance with …

Total Energy Expenditure Is Repeatable In Adults But Not Associated With Short-Term Changes In Body Composition, Rebecca Rimbach, Yosuke Yamada, Hiroyuki Sagayama, Philip N Ainslie, Lene F Anderson, Liam J Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G J A Camps, Graeme L Close, Jamie A Cooper, Sai Krupa Das, Lara R Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, Misaka Kimura, William E Kraus, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby K Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Cornelia U Loechl, Amy H Luke, Jennifer Rood, Dale A Schoeller, Klaas R Westerterp, William W Wong, John R Speakman, Herman Pontzer

Children’s Nutrition Research Center Staff Publications

Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but …

Fine Ash-Bearing Particles As A Major Aerosol Component In Biomass Burning Smoke, Kouji Adachi, Jack E. Dibb, Eric Scheuer, Joseph M. Katich, Joshua P. Schwarz, Anne E. Perring, Braden Mediavilla, Hongyu Guo, Pedro Campuzano-Jost, Jose L. Jimenez, James Crawford, Amber J. Soja, Naga Oshima, Mizuo Kajino, Takeshi Kinase, Lawrence Kleinman, Arthur J. Sedlacek Iii, Robert J. Yokelson, Peter R. Buseck

Faculty Publications

Biomass burning (BB) events are occurring globally with increasing frequency, and their emissions are having more impacts on human health and climate. Large ash particles are recognized as a BB product with major influences on soil and water environments. However, fine-ash particles, which have diameters smaller than several microns and characteristic morphologies and compositions (mainly Ca and Mg carbonates), have not yet been explicitly considered as a major BB aerosol component either in field observations or climate models. This study measured BB aerosol samples using transmission electron microscopy (TEM) and ion chromatography during the Fire Influence on Regional to Global …

Fine Ash-Bearing Particles As A Major Aerosol Component In Biomass Burning Smoke, Kouji Adachi, Jack E. Dibb, Eric Scheuer, Joseph M. Katich, Joshua P. Schwarz, Anne E. Perring, Braden Mediavilla, Hongyu Guo, Pedro Campuzano-Jost, Jose L. Jimenez, James Crawford, Amber J. Soja, Naga Oshima, Mizuo Kajino, Takeshi Kinase, Lawrence Kleinman, Arthur J. Sedlacek Iii, Robert J. Yokelson, Peter R. Buseck

Faculty Publications

Biomass burning (BB) events are occurring globally with increasing frequency, and their emissions are having more impacts on human health and climate. Large ash particles are recognized as a BB product with major influences on soil and water environments. However, fine-ash particles, which have diameters smaller than several microns and characteristic morphologies and compositions (mainly Ca and Mg carbonates), have not yet been explicitly considered as a major BB aerosol component either in field observations or climate models. This study measured BB aerosol samples using transmission electron microscopy (TEM) and ion chromatography during the Fire Influence on Regional to Global …

Microbial Enzymes Induce Colitis By Reactivating Triclosan In The Mouse Gastrointestinal Tract, Jianan Zhang, Morgan E. Walker, Katherine Z. Sanidad, Hongna Zhang, Michael B. Major, Dennis Goldfarb, Et Al

Open Access Publications

No abstract provided.

Total Energy Expenditure Is Repeatable In Adults But Not Associated With Short-Term Changes In Body Composition, Rebecca Rimbach, Susan B. Racette, John R. Speakman, Herman Pontzer, Et Al

Open Access Publications

No abstract provided.

The Allergy Mediator Histamine Confers Resistance To Immunotherapy In Cancer Patients Via Activation Of The Macrophage Histamine Receptor H1, Hongzhong Li, Yi Xiao, Qin Li, Jun Yao, Xiangliang Yuan, Yuan Zhang, Xuedong Yin, Yohei Saito, Huihui Fan, Ping Li, Wen-Ling Kuo, Angela Halpin, Don L Gibbons, Hideo Yagita, Zhongming Zhao, Da Pang, Guosheng Ren, Cassian Yee, J Jack Lee, Dihua Yu

Faculty, Staff and Student Publications

Reinvigoration of antitumor immunity remains an unmet challenge. Our retrospective analyses revealed that cancer patients who took antihistamines during immunotherapy treatment had significantly improved survival. We uncovered that histamine and histamine receptor H1 (HRH1) are frequently increased in the tumor microenvironment and induce T cell dysfunction. Mechanistically, HRH1-activated macrophages polarize toward an M2-like immunosuppressive phenotype with increased expression of the immune checkpoint VISTA, rendering T cells dysfunctional. HRH1 knockout or antihistamine treatment reverted macrophage immunosuppression, revitalized T cell cytotoxic function, and restored immunotherapy response. Allergy, via the histamine-HRH1 axis, facilitated tumor growth and induced immunotherapy resistance in mice and humans. …

Conflicting Interests And Growing Importance Of Non‐Indigenous Species In Commercial And Recreational Fisheries Of The Mediterranean Sea, Periklis Kleitou, Dimitrios K. Moutopoulos, Ioannis Giovos, Demetris Kletou, Ioannis Savva, Leda L. Cai, Jm Hall‐Spencer, Anastasia Charitou, Maria Elia, George Katselis, Siân Rees

School of Biological and Marine Sciences

No abstract provided.

A Novel 3d Animation About Human Visual System: From Retina To Perception, Qiuwan Liu

Theses

Introduction to vision and perception has been a fundamental topic for students from varied majors in college. Students who study Biology, Cognitive Science, Neuroscience, and Visual Design, need to learn about the visual pathway before they dive into more specific research topics. This thesis intends to create a 3D animation to assist professors explaining the complex process of the visual pathway. The target audience for this project is undergraduate students majoring in color science. My goal of this animation is to introduce students to the complicated anatomy of the retinal structure and the molecular pathway of the photoreceptors to demonstrate …

Secretogranin Iii Stringently Regulates Pathological But Not Physiological Angiogenesis In Oxygen-Induced Retinopathy, Chang Dai, Prabuddha Waduge, Liyang Ji, Chengchi Huang, Ye He, Hong Tian, Elizabeth Zuniga-Sanchez, Amit Bhatt, Iok-Hou Pang, Guanfang Su, Keith A Webster, Wei Li

Faculty, Staff and Students Publications

Conventional angiogenic factors, such as vascular endothelial growth factor (VEGF), regulate both pathological and physiological angiogenesis indiscriminately, and their inhibitors may elicit adverse side effects. Secretogranin III (Scg3) was recently reported to be a diabetes-restricted VEGF-independent angiogenic factor, but the disease selectivity of Scg3 in retinopathy of prematurity (ROP), a retinal disease in preterm infants with concurrent pathological and physiological angiogenesis, was not defined. Here, using oxygen-induced retinopathy (OIR) mice, a surrogate model of ROP, we quantified an exclusive binding of Scg3 to diseased versus healthy developing neovessels that contrasted sharply with the ubiquitous binding of VEGF. Functional immunohistochemistry visualized …

Mutations In Hcfc1 And Ronin Result In An Inborn Error Of Cobalamin Metabolism And Ribosomopathy, Tiffany Chern, Annita Achilleos, Xuefei Tong, Matthew C Hill, Alexander B Saltzman, Lucas C Reineke, Arindam Chaudhury, Swapan K Dasgupta, Yushi Redhead, David Watkins, Joel R Neilson, Perumal Thiagarajan, Jeremy B A Green, Anna Malovannaya, James F Martin, David S Rosenblatt, Ross A Poché

Faculty, Staff and Students Publications

Combined methylmalonic acidemia and homocystinuria (cblC) is the most common inborn error of intracellular cobalamin metabolism and due to mutations in Methylmalonic Aciduria type C and Homocystinuria (MMACHC). Recently, mutations in the transcriptional regulators HCFC1 and RONIN (THAP11) were shown to result in cellular phenocopies of cblC. Since HCFC1/RONIN jointly regulate MMACHC, patients with mutations in these factors suffer from reduced MMACHC expression and exhibit a cblC-like disease. However, additional de-regulated genes and the resulting pathophysiology is unknown. Therefore, we have generated mouse models of this disease. In addition to exhibiting loss of Mmachc, metabolic perturbations, and developmental defects previously …

The Allergy Mediator Histamine Confers Resistance To Immunotherapy In Cancer Patients Via Activation Of The Macrophage Histamine Receptor H1, Hongzhong Li, Yi Xiao, Qin Li, Jun Yao, Xiangliang Yuan, Yuan Zhang, Xuedong Yin, Yohei Saito, Huihui Fan, Ping Li, Wen-Ling Kuo, Angela Halpin, Don L Gibbons, Hideo Yagita, Zhongming Zhao, Da Pang, Guosheng Ren, Cassian Yee, J Jack Lee, Dihua Yu

Duncan NRI Faculty and Staff Publications

Reinvigoration of antitumor immunity remains an unmet challenge. Our retrospective analyses revealed that cancer patients who took antihistamines during immunotherapy treatment had significantly improved survival. We uncovered that histamine and histamine receptor H1 (HRH1) are frequently increased in the tumor microenvironment and induce T cell dysfunction. Mechanistically, HRH1-activated macrophages polarize toward an M2-like immunosuppressive phenotype with increased expression of the immune checkpoint VISTA, rendering T cells dysfunctional. HRH1 knockout or antihistamine treatment reverted macrophage immunosuppression, revitalized T cell cytotoxic function, and restored immunotherapy response. Allergy, via the histamine-HRH1 axis, facilitated tumor growth and induced immunotherapy resistance in mice and humans. …

Fall 2021 Full Issue, Journal Of Counseling Sexology & Sexual Wellness: Research Education, And Practice Jcssw

Journal of Counseling Sexology & Sexual Wellness: Research, Practice, and Education

No abstract provided.

Mapping Sex Therapy Across The United States: An Exploratory Study, Frances L. Mcclain, Dylan M. Amlin

Journal of Counseling Sexology & Sexual Wellness: Research, Practice, and Education

The primary purpose of this study was to determine what someone who was interested in obtaining a provider for sex therapy would find if they simply searched for sex therapy using the Google search engine. The goal was to ascertain how someone might access providers in each state, what types of information someone seeking treatment for sexuality issues might find on provider websites, who is providing the services, what types of services are being provided, and whose services might appeal to given the content of the website. Once all of the data was compiled, the resulting data would include a …

Can High Density, Short Duration Grazing Replace Fire In A South African Mesic Grassland?, N. M. Chonco, S. C. Nkuna

IGC Proceedings (1977-2023)

High density grazing (HDG), defined as the concentration of many livestock on a small area for a short period of time has become increasingly popular in the South African mesic grassland yet little is known about it impact. HDG is usually applied without fire, based on the assertion that it is a key contributor to desertification of grasslands. However, fire plays an important role in the development and growth of most South African mesic grassland plant species, as it stimulates resprouting and reduces competition for light. The aim of this study was to determine the impacts of high density grazing …

Back To The Roots - Do Traditional Maasai Management Strategies Work Towards Resilience Against Unpredictable Rainfall And Grazing Pressure In Northern Tanzania?, S. A. Baumgartner, A. C. Treydte

IGC Proceedings (1977-2023)

Despite the importance for people´s livelihoods, many semi-arid African savannas are prone to heavy degradation due to overutilization by people, livestock and increased climate variability. Rangeland management, such as transhumance and deferred grazing systems, practiced by the Maasai in northern Tanzania, can be useful in combating the negative consequences of overuse and increasing rainfall variability. But little is known on how different rangeland regimes, practiced by the Maasai, impacts the productivity of these rangelands.

We collected data on regrowth rates under different rangeland management regimes (rainy season grazing land, dry season grazing land, and seasonal exclosures), different harvest rates (month, …

Assessment Of Rangeland Condition In A Dryland System Using Uav-Based Multispectral Imagery, V. Amputu, K. Tielbörger, N. Knox

IGC Proceedings (1977-2023)

Dry savannahs are water-limited and under increasing anthropogenic pressure. Thus, considering climate change and the unprecedented pace and scale of rangeland deterioration, we need methods for assessing the status of such rangelands that are easy to apply, yield reliable and repeatable results that can be applied over large spatial scales. Global and local scale monitoring of rangelands through satellite data and labour-intensive field measurements respectively, are limited in accurately assessing the spatiotemporal heterogeneity of vegetation dynamics to provide crucial information that detects degradation in its early stages. Fortunately, newly emerging techniques such as unmanned aerial vehicles (UAVs), associated miniaturized sensors …

An Integrated Framework To Study Ecological Tipping Points In Social-Ecological Systems, F. A. Männer, L.-M. Schwarz, D. A. Menestrey-Schwieger, V. Amputu, M. C. Bilton, K. Brinkmann, G. Dressler, N. Hamunyela, H. Heita, S. Heshmati, S. Liehr, M. Mbidzo, F. Munyebvu-Chambara, W. C. Nesongano, M. Rauchecker, A. Sandhage-Hofmann, K. Tielbörger, K. Zimmer, A. Linstädter

IGC Proceedings (1977-2023)

Sudden regime shifts or tipping points pose a major threat to various ecosystems and people's livelihoods worldwide. However, tipping points are still hard to predict and often occur without warning. To avoid dramatic social-ecological consequences, it is crucial to understand tipping point behaviour and to identify early warning indicators. Previous studies have hardly implemented an integrated social-ecological approach, which has led to a fragmented understanding and oversimplification of tipping point phenomena. Against this background, we present a systemic research framework that harmonizes ecological and social perspectives to gain a mechanistic understanding of tipping point behaviour. We utilize a social-ecological systems …

An Integrated Assessment And Management Optimization System For Grazinglands, D. Toledo, J. E. Herrick, S. Goslee, M. Sanderson

IGC Proceedings (1977-2023)

Rangelands and pasturelands are often assessed using different methodologies. The Interpreting Indicators of Rangeland Health and Pasture Condition Scoring methodologies, two techniques used widely across the USA, were developed for rangelands and pasturelands respectively. These two grazingland assessment techniques were determined to be complementary and if integrated could provide an optimized approach to measure grazinglands without regards to specific use (i.e. range or pasture). We present an improved grazingland assessment protocol that merges indicators and attributes from Interpreting Indicators of Rangeland Health and Pasture Condition Scoring methodologies. This Integrated Grazingland Assessment (IGA) approach allows evaluators to assess site conditions and …

Learning Systems In Schools And At Work, Richard D. Busby

Publications & Research

Key Points in this Post:

1. Learning systems in schools differ from learning systems at work
2. The content is different
3. The context is different
4. The complexity is different, specifically about promotion criteria

Question explored: Is it time to assess the current K-12 education system paradigm in order to adapt to the future of work?

Magnetic Nanoparticles Enhanced Surface Plasmon Resonance Biosensor For Rapid Detection Of Salmonella Typhimurium In Romaine Lettuce, Devendra Bhandari, Fur-Chi Chen, Roger C. Bridgman

Human Sciences Faculty Research

Salmonella is one of the major foodborne pathogens responsible for many cases of illnesses, hospitalizations and deaths worldwide. Although different methods are available to timely detect Salmonella in foods, surface plasmon resonance (SPR) has the benefit of real-time detection with a high sensitivity and specificity. The purpose of this study was to develop an SPR method in conjunction with magnetic nanoparticles (MNPs) for the rapid detection of Salmonella Typhimurium. The assay utilizes a pair of well-characterized, flagellin-specific monoclonal antibodies; one is immobilized on the sensor surface and the other is coupled to the MNPs. Samples of romaine lettuce contaminated with …

Omega-6 And Omega-3 Fatty Acid-Derived Oxylipins From The Lipoxygenase Pathway In Maternal And Umbilical Cord Plasma At Delivery And Their Relationship With Infant Growth, Maranda Thompson, Arzu Ulu, Ana G. Yuil-Valdes, Maheswari Mukherjee, Melissa K. Thoene, Matthew Van Ormer, Rebecca Slotkowski, Elizabeth Lyden, Ann Anderson-Berry, Corrine K. Hanson, Tara M. Nordgren, Sathish Kumar Natarajan

Department of Nutrition and Health Sciences: Faculty Publications

Omega-3 and omega-6 fatty acids are important for neonatal development and health. One mechanism by which omega-3 and omega-6 fatty acids exert their effects is through their metabolism into oxylipins and specialized pro-resolving mediators. However, the influence of oxylipins on fetal growth is not well understood. Therefore, the objective of this study was to identify oxylipins present in maternal and umbilical cord plasma and investigate their relationship with infant growth. Liquid chromatography–tandem mass spectrometry was used to quantify oxylipin levels in plasma collected at the time of delivery. Spearman’s correlations highlighted significant correlations between metabolite levels and infant growth. They …

2022-January-09-Free Pharmacy Dual Enrollment Class Registration Deadline Jan. 23, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (January 9, 2022) – East Tennessee State University Bill Gatton College of Pharmacy is offering a free college class for dual enrollment high school students across the region to learn more about the pharmacy profession and how to get into pharmacy school. The course will be free for all students who have a 3.0 high school GPA or above and are dual enrolled. ETSU undergraduate students may also pay to register for the course. This course will be online and asynchronous, meaning students can participate at any point.

REGISTER BY JAN. 23

“Training future pharmacists to serve in …

Using Metabolic Potential Within The Airway Microbiome As Predictors Of Clinical State In Persons With Cystic Fibrosis, Gabriella Shumyatsky, Aszia Burrell, Hollis Chaney, Iman Sami, Anastassios C Koumbourlis, Robert J Freishtat, Keith A Crandall, Edith T Zemanick, Andrea Hahn

Department of Medical Laboratory Sciences & Biotechnology Faculty Papers

Introduction: Pulmonary exacerbations (PEx) in persons with cystic fibrosis (CF) are primarily related to acute or chronic inflammation associated with bacterial lung infections, which may be caused by several bacteria that activate similar bacterial genes and produce similar by-products. The goal of our study was to perform a stratified functional analysis of bacterial genes at three distinct time points in the treatment of a PEx in order to determine the role that specific airway microbiome community members may play within each clinical state (i.e., PEx, end of antibiotic treatment, and follow-up). Our secondary goal was to compare the change between …

The Use Of Microalgal Sourced Biodiesel To Help Underground Mines Transition To Battery Electric Vehicles, Corey A. Laamanen, Kyle Moreau, Sabrina M. Desjardins, Shannon H. Mclean, John A. Scott

Journal of Sustainable Mining

The use of fossil fuel sourced diesel underground has various associated health and environmental hazards, and additional energy demand and costs associated with necessary ventilation. One way to reduce these impacts is by utilizing a biodieselblend, which generates lower levels of harmful emissions from underground equipment and can be produced regionally, reducing the impact of transportation. Furthermore, this would help allow use of existing machinery during transition towards more widespread electrification underground. Therefore, the concept of an integrated supply and use chain within the mining industry is examined based on biodiesel from acidophilic photosynthetic microalgae cultivated using CO 2 in …

Application Of Entropy Method For Estimating Factor Weights In Mining-Method Selection For Development Of Novel Mining-Method Selection System, Elsa Pansilvania Andre Manjate, Mahdi Saadat, Hisatoshi Toriya, Fumiaki Inagaki, Youhei Kawamura

Journal of Sustainable Mining

Mining-method selection (MMS) is one of the most critical and complex decisionmaking processes in mine planning. Therefore, it has been a subject of several studies for many years culminating with the development of different systems. However, there is still more to be done to improve and/or create more efficient systems and deal with the complexity caused by many influencing factors. This study introduces the application of the entropy method for feature selection, i.e., select the most critical factors in MMS. The entropy method is applied to assess the relative importance of the factors influencing MMS by estimating their objective weights …

Evolutionary Analyses Of Visual Opsin Genes In Frogs And Toads: Diversity, Duplication, And Positive Selection, Ryan K. Schott, Leah Perez, Matthew Kwiatkowski, Vance Imhoff, Jennifer M. Gumm

Faculty Publications

Among major vertebrate groups, anurans (frogs and toads) are understudied with regard to their visual systems, and little is known about variation among species that differ in ecology. We sampled North American anurans representing diverse evolutionary and life histories that likely possess visual systems adapted to meet different ecological needs. Using standard molecular techniques, visual opsin genes, which encode the protein component of visual pigments, were obtained from anuran retinas. Additionally, we extracted the visual opsins from publicly available genome and transcriptome assemblies, further increasing the phylogenetic and ecological diversity of our dataset to 33 species in total. We found …