Digital Commons Network^™

Expanding And Refining The Mammalian Phenotype Ontology To Enhance Disease Model Discovery., Susan M. Bello, Anna V Anagnostopoulos, Leigh Carmody, Nicolas Matentzoglu, Cynthia Smith

Faculty Research 2025

The mouse is a premier model system for investigating gene function and modeling human disease. For almost 40 years, Mouse Genome Informatics has worked to capture and integrate the data generated from mouse studies. A critical component of this integration is the development and use of the Mammalian Phenotype (MP) Ontology to capture the morphological and physiological effects of alterations to gene function in the mouse. As the wealth of phenotype data captured using the MP has expanded, its utility in the diagnosis of human disease has increased. Tools have been developed to use mouse and human phenotypes in variant …

Sociocultural And Environmental Changes And Their Biological Impact On Nonelite Polish Individuals, Paige A. Lynch

Anthropology ETDs

This dissertation integrates isotopic, biodistance, and skeletal stress data from cemeteries, Gać and Pień to study health and survival in the Polish–Lithuanian Commonwealth (PLC). The PLC (16th–18th centuries) in Poland was marked by religious migration, social inequality, and environmental change. Chapter 2 used a multiproxy approach to identify migrant status: most at Pień were local, about half at Gać were migrants, often biologically related to locals. Chapter 3 used stable isotope analyses to find minimal sex-based dietary differences, except for Pień females’ higher millet intake, and showed that market access and feudal systems influenced subsistence strategies. Chapter 4’s survival analyses …

Neuronal Activity-Dependent Gene Dysregulation In C9orf72 I3neuronal Models Of Als/Ftd Pathogenesis, Layla T. Ghaffari, Emily A. Welebob, Sarah E. Bond Newton, Ashley V. Boehringer, Kelly L. Cyliax, Piera Pasinelli, Davide Trotti, Aaron R. Haeusler

Farber Institute for Neuroscience Faculty Papers

The GGGGCC nucleotide repeat expansion (NRE) mutation in the C9ORF72 (C9) gene is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Neuronal activity plays an essential role in shaping biological processes within both healthy and neurodegenerative disease scenarios. Here, we show that at baseline conditions, C9-NRE-induced pluripotent stem cell-cortical neurons display aberrations in several pathways, including synaptic signaling and transcriptional machinery, potentially priming diseased neurons for an altered response to neuronal stimulation. Indeed, exposure to two pathophysiologically relevant stimulation modes, prolonged membrane depolarization or a blockade of K⁺ channels, followed by RNA sequencing, induces …

Issue 15: Pulmonary & Critical Care Insider, Bharat Bajantri Md, Sarah Ellsworth-Hoffman Mls, Kristin Lytal Pharmd, Mspgx, Stephanie Subart Pharmd

Critical Care & Pulmonary

Pulmonary & Critical Care Insider Issue 15

Compiled by Bharat Bajantri, MD, and librarian Sarah Ellsworth, MLS for the clinicians of the Pulmonary and Critical Care team of Parkview.

The Pulmonary & Critical Care Insider newsletter was created by Dr. Bharat Bajantri, MD and Sarah Ellsworth, MLS in 2023 as a form of current awareness for current practice at our hospital, Parkview Health.

Topics:

2025 Guidelines for ANCA Vasculitis

Airway Scaffolds for Emphysema: Six-Month BREATHE TRIAL Results

Tackling Emphysema-Related Hyperinflation: Scaffolds, Valves, or Vapor? How They Work?

Bactericidal vs. Bacteriostatic Antibiotics in Critically Ill Patients

Modified Cuff Leak Test (CLT) …

Icipe Monthly Digest – Volume 1, Issue 10, October 2025, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Newsletters

No abstract provided.

Gonzaga Digital Scholarship & Publishing Newsletter, Fall 2025, Foley Center Library

Foley Library Publications

Volume 2 of the Digital Scholarship & Publishing Newsletter (formerly Gonzaga Institutional Repository Newsletter).

In this issue: 

• Learn about Pure Faculty Profiles
• Find out about the Digital Scholarship Lab @ Foley Library 
• Read about options for publishing OERs
• Explore how your department’s research and scholarship is represented in the IR
• Find out where to go for Copyright and Intellectual Property questions
• Data Management Plan consultations and options for support

Biomass Materials And Their Application In 4d Printing, Zhongda Yang, Jian Li, Yanling Guo, Yangwei Wang, Wen Zhao, Wei Zhao, Yanju Liu, Laichang Zhang

Research outputs 2022 to 2026

Four-dimensional (4D) printing technology is a revolutionary development that produces structures that can adapt in response to external stimuli. However, the responsiveness and printability of smart materials with shape memory properties, which are necessary for 4D printing, remain limited. Biomass materials derived from nature have offered an effective solution due to their various excellent and unique properties. Biomass materials have been abundant in resources and low in carbon content, contributing to the then-current global green energy-saving goals, including carbon peaking and carbon neutrality. This review focused on different sources of biomass materials used in 4D printing, including plant-based, animal-based, and …

Physicochemical And Structural Optimization Of Date (Phoenix Dactylifera L.) Syrup: Impact Of Extraction Temperatures And Pectin Addition, Afna Thaivalappil Abdul Asiz

Theses

This thesis focuses on the optimization of date (Phoenix dactylifera L.) syrup, an emerging natural sweetener rich in glucose, fructose, and bioactive compounds, by investigating how extraction temperature and pectin incorporation influence its physicochemical and structural properties. Therefore, the main objective of this study was to examine how extraction temperatures (25°C, 50°C, 75°C, and 90°C), and the incorporation of lowmethoxyl pectin (LMP, DE 31%) and high-methoxyl pectin (HMP, DE 85%) prior to concentration, affect the quality, stability, and functionality of date syrup. The results showed that increasing extraction temperatures increased the total soluble solids (16 °Brix at 25°C to …

Advances In Iot, Ai, And Sensor‑Based Technologies For Disease Treatment, Health Promotion, Successful Ageing, And Ageing Well, Yuzhou Qian, Keng Siau

Research Collection School Of Computing and Information Systems

Recent advancements in the Internet of Things (IoT) and artificial intelligence (AI) are unlocking transformative opportunities across society. One of the most critical challenges addressed by these technologies is the ageing population, which presents mounting concerns for healthcare systems and quality of life worldwide. By supporting continuous monitoring, personal care, and data-driven decision-making, IoT and AI are shifting healthcare delivery from a reactive approach to a proactive one. This paper presents a comprehensive overview of IoT-based systems with a particular focus on the Internet of Healthcare Things (IoHT) and their integration with AI, referred to as the Artificial Intelligence of …

Soft Sensing Of Biological Oxygen Demand In Industrial Wastewater Using Machine Learning Models, Muhammad Hassnain, Sarada M.W. Lee, Muhammad Rizwan Azhar

Research outputs 2022 to 2026

Traditional methods for determining biological oxygen demand (BOD) from industrial water resource recovery facilities (WRRFs) are time-consuming and often impractical for real-time process control. This study explores the application of machine learning (ML) and artificial intelligence (AI) models for the prediction of final effluent BOD (F-BOD) based on physicochemical and operational parameters by leveraging nineteen years of historical laboratory and instrumentation data from the WRRF of an essential oil manufacturing plant. The predictions from these models are then used to simulate the process dynamics, assessing the optimal operational boundary conditions for all input parameters at which the target (F-BOD) falls …

Systematic Review And Meta-Analysis Of Microrna-7-5p Expression And Biological Significance In Head And Neck Squamous Cell Carcinoma, Rikki A.M. Brown, Michael Phillips, Andrew J. Woo, Omar Kujan, Stephanie Flukes, Louise N. Winteringham, Larissa C. Dymond, Fiona Wheeler, Brianna Pollock, Dianne J. Beveridge, Elena Denisenko, Peter J. Leedman

Research outputs 2022 to 2026

Background: Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy with poor clinical outcomes. microRNA-7-5p (miR-7-5p) has been described as both a tumour suppressor and an oncomiR depending on the tissue context, but its role in HNSCC remains unclear. This study aimed to clarify the clinical significance and biological function of miR-7-5p in HNSCC by integrating data from multiple sources. Methods: A systematic review of the literature was conducted to identify studies analysing miRNA expression in human head and neck tissues. A meta-analysis of individual patient data from Gene Expression Omnibus (GEO), ArrayExpress, and The Cancer Genome Atlas …

The Consequences Of Habitual Rumination, Expressive Suppression, And Perceived Stress On Mental And Physical Health Among Older Adults, Eyal Gringart, Rodrigo Becerra, Andrea Smith

Research outputs 2022 to 2026

Background/Objectives: The current study aimed to investigate whether habitual rumination, suppression, and perceived stress predict poor mental and physical health as well as well-being in a group of older adults (aged 50 to 80 years) from a non-clinical community sample. Methods: The current study comprised a cross-sectional survey design with online self-report measures. It was predicted that higher levels of rumination, suppression, and perceived stress would predict lower levels of general health as well as well-being, and heightened levels of depression and anxiety. Results: Findings from the study indicated that both rumination and perceived stress significantly predicted heightened anxiety, heightened …

Validation Of A Mind Diet Screener In Older Adults, Desarae A. Dempsey, Puja Agarwal, Shane Fernandez, Jared R. Brosch, Sujuan Gao, Daniel O. Clark, Frederick W. Unverzagt, Liana G. Apostolova, David G. Clark, Martin R. Farlow, Sunu Mathew, Sophia Wang, Michelle Quirke, Yolanda Graham-Dotson, Colette Blach, Leyla Schimmel, Rima Kaddurah-Daouk, Andrew J. Saykin, Shannon L. Risacher

Research outputs 2022 to 2026

Introduction: Higher adherence to the Mediterranean-DASH (Dietary Approaches to Stop Hypertension) Intervention for Neurodegenerative Delay (MIND) diet has been associated with reduced Alzheimer's disease (AD) risk. This study assessed the validity of a brief 15-item MIND diet screener compared to a comprehensive food frequency questionnaire (FFQ). Methods: The validity of an adapted MIND diet screener relative to the VioScreen FFQ was evaluated in 92 older adults from the Indiana Alzheimer's Disease Research Center (IADRC). Correlation coefficients and tertile-based classification statistics were used, and FFQ nutrient profiles were examined across screener-based MIND diet tertiles. Results: MIND diet scores from the screener …

Lawrence, Fall/Winter 2025, Lawrence University

Alumni Magazines

No abstract provided.

Campus Chronicle, Jayden Park

Campus Chronicle

Special Ankeny, Urban, Boone Issue

Ua 64/2 The Challenge: Magazine For The Center For Gifted Studies (No. 59 Fall 2025), Elizabeth Joyce Editor

Gifted Studies Publications

Magazine created by and about the WKU Center for Gifted Studies.

From Summer Institute To Action: Advancing Equity And Inclusion In Stem Classrooms, Sandie Han, Nadia Kennedy, Malgorzata Marciniak, Diana Samaroo

Publications and Research

This Editor’s Note provides background on the CUNY Innovative Teaching Academy Summer Institute for Equitable and Inclusive STEM Teaching and Learning and introduces the articles featured in this special issue.

Otterbein Towers Fall 2025, Otterbein University

Towers Magazine

Around the 'Bein; Innovative Funds; Committed to Career and Community; Faculty Excellence and Innovation; Two Years of Education for the Common Good; Homecoming and Family Weekend; Philanthropy; Alumni Matters; Class Notes.

Grand Valley Magazine, Vol. 25, No. 1, Fall 2025, Grand Valley State University

Grand Valley Magazine

Grand Valley Magazine is a quarterly publication about Grand Valley State University produced by University Communications since 2001.

Level Up: How Video Games Can Be Beneficial And Spark Creative Imagination In Players, Makendra M. Phipps

Honors Theses

Since the 2010’s, a technological trend has been flourishing: the development and enhancement of video games across different platforms. The early 1970s began the evolution of video game systems, from Atari and Magnavox Odyssey (1972) to Game Boy (1989) to Nintendo Switch 2 (2025) today. Video games themselves have also evolved, from the first basic computer games of the 1950s (such as OXO and Tennis for Two), to the introduction of arcade games in the 1970s (Pong, Space Invaders, PAC-Man), to the popular video games of today (Grand Theft Auto, Minecraft, Fortnite, R.E.P.O., to name …

From Chaos To Calm: How Ferappease Shapes Calf Behavior And Eases Weaning Woes, Rinna Tarter

Honors Theses

Weaning is widely recognized as one of the most stressful practices within the beef industry, as calves are separated from their dams and must manage changes in environment, social structure, and nutrition. This process provides indicators of stress, including increased vocalizations, reduced feed intake, pacing, and a stop in weight gain. Traditional management strategies include fenceline separation, nose flaps, and abrupt separation. Some research has begun to investigate approaches that target the biological mechanisms underlying the physiological stress response. One approach involves the use of a maternal bovine appeasing substance (mBAS), a synthetic analog of pheromones produced naturally by lactating …

Double Lenses: Understanding Adhd–Autism Comorbidity Across Gender And Pathways To Intervention, Grace A. Peak

Honors Theses

Each year, the number of people diagnosed with attention deficit hyperactivity disorder (ADHD) and Autism Spectrum Disorder (ASD) rises. This rising number is due to the abundance of research done on each disorder. Because of this increase in information, many adults and children are getting a comorbid diagnosis, meaning that they are being diagnosed with both disorders at the same time. There is one catch, however; research has shown that ADHD and ASD are spectrums, meaning that they have symptoms that can range in frequency and severity while also affecting each person differently. A large portion of the research conducted …

Maternal Nutritional Status And Immune Regulation In Early Offspring Development, Caroline C. Pagan

Honors Theses

Maternal nutrition, immune function, and microbiome health work together to shape fetal development in ways that influence health across the lifespan and even into future generations. This paper synthesizes evidence from molecular biology, nutrition science, immunology, and public health to show that essential nutrients-such as omega-3 fatty acids, folate, iron, zinc, and vitamin D-directly affect fetal immune programming, neurodevelopment, placental function, and metabolic regulation. Research on the maternal microbiome further demonstrates that microbial diversity and metabolite production modify nutrient absorption, inflammatory balance, and fetal gene expression, underscoring the microbiome’s role as both a mediator and amplifier of nutritional effects. At …

Social Drivers Of Health: Shifting The Focus Of Health Indicators From The Biological Code To The Zip Code, Jenna M. Barlage

Honors Theses

This study explored how healthcare facilities in Kentucky and Ohio are adapting to the Centers for Medicare & Medicaid Services’ (CMS) 2024 mandate requiring the collection and reporting of Social Drivers of Health (SDOH) data. Through literature review and interviews with healthcare administrators responsible for SDOH screening, documentation, and reporting, the research evaluated the central hypothesis: while the mandate has expanded the amount of available SDOH data, healthcare organizations continue to face substantial financial, technological, and organizational barriers in addressing identified patient needs. Findings indicated that many facilities have broadened and standardized their screening practices, leading to clearer early trends …

The Leap Through Reality: The Connections Between Quantum Leap’S Tropes Within Natural Science, Annamarie G. Seamans

Honors Theses

Quantum Leap aired in 1989 and became known for the show's combination of science fiction tropes. The combination of switching consciousness and time travel was an uncommon method for storytelling and stood out among the many science fiction shows released in the 1980s. Time travel has been a storytelling tool for centuries and many scientists have developed theories that allow time travel to be possible in the natural world. Many of the theories developed become improbable due to causality. However, if causality is no longer maintained there are models of time travel that become more likely. Similarly, the science behind …

The Impact Of Environmental Factors On Blood Detection: Effects Of Uv And Temperature On Blood Samples, Delaney Mccarthy

Honors Theses

Biological evidence, such as blood, is one of the most important types of forensic evidence collected from crime scenes. Blood can provide valuable information that can help identify victims, perpetrators, and give insight into what transpired. However, outdoor environments leave biological samples exposed to changing and often harsh weather conditions that can compromise the evidence’s integrity. Ultraviolet (UV) light and variable temperatures are two major factors that can degrade both the physical and chemical properties of blood. This study aimed to determine the effects of UV exposure on the detection and analysis of human blood using presumptive and confirmatory serological …

Volumetric Differences Of Thalamic Nuclei Are Associated With Posttrauma Psychopathology, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Background

Previous investigations of whole thalamus and thalamic nuclei volumes in posttrauma psychopathology have been sparse and limited in scope and have yielded inconsistent results. To address this, volumetric estimates of whole thalamus and thalamic nuclei were obtained from structural brain magnetic resonance imaging scans from 2058 participants across 20 worldwide sites in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Posttraumatic Stress Disorder (PTSD) working group.

Methods

Thalamic volumes were compared in trauma-exposed participants with PTSD (n = 238), major depressive disorder (MDD) (n = 184), and comorbid PTSD+MDD (n = 618) and in trauma-exposed …

Do Honey Phytochemicals Modulate Forager Aggression And The Gut Microbiome In The Honey Bee (Apis Mellifera L.)?, Wade A. Pike, Jaesylin Stephens, Mariah Donohue, Katsuri Rajandran, Erin D. Tranore, Abdallah Sher, Emily Croteau, Clare C. Rittschof

Biology Faculty Publications

Plant phytochemicals found in nectar impact bee learning and memory and plant pollination success. Especially for generalist pollinators, dietary changes that alter phytochemical consumption could be common sources of behavioral variation. For honey bee (Apis mellifera L.) foragers, a major potential change in phytochemical consumption occurs when individuals switch from collecting nectar from flowers to collecting honey from neighboring colonies, a phenomenon known as honey robbing. In this study we investigated whether phytochemicals dominant in honey compared to nectar act as a short-term trigger of robbing behaviors in honey bee, which include increased aggression. We fed forager honey bees sucrose …

Estimating (Non)Linear Selection On Reaction Norms, Jordan S. Martin, Yimen G. Araya-Ajoy, Niels J. Dingemanse, Alastair J. Wilson, David F. Westneat

Biology Faculty Publications

Individual reaction norms describe how labile phenotypes vary as a function of organisms' expected trait values (intercepts) and plasticity across environments (slopes), as well as their degree of stochastic phenotypic variability or predictability (residuals). These reaction norms can be estimated empirically using multilevel, mixed-effects models and play a key role in ecological research on a variety of behavioral, physiological, and morphological traits. Many evolutionary models have also emphasized the importance of understanding reaction norms as a target of selection in heterogeneous and dynamic environments. However, it remains difficult to empirically estimate nonlinear selection on reaction norms, inhibiting robust tests of …

Estrogen Signaling Is Necessary For The Sex Difference In Simulated Jet Lag In Mice, Maria A. Venegas, Nicholas Westray, Samuel Nwadialo, Yuriko Katsumata, Julie S. Pendergast

Biology Faculty Publications

The circadian system coordinates 24-h cycles of internal biological processes with the environmental light-dark cycle. Abrupt shifts in the timing of the light-dark cycle misalign internal circadian clocks with the environment and cause jet lag until resynchronization occurs. The objective of this study was to investigate the sex difference in simulated jet lag in mice. Female mice resynchronized faster than male mice to 6-h advances of the light-dark cycle that mimicked eastward travel. Circulating estradiol was necessary and sufficient for rapid resynchronization in female mice since ovariectomized females resynchronized slower than mice treated with estradiol. Disabling estrogen receptor a (ERa), …