Digital Commons Network^™

Mle And Eap Methods For Estimating Ability Scores For Data Of Varying Sample Size And Item Length, Sahar Taji

Graduate Theses and Dissertations

In this research, the performance of two popular estimators, Maximum Likelihood Estimator(MLE) and Bayesian Expected a Posteriori (EAP) is studied and compared in estimating the latent ability score in an Item Response Theory (IRT) model. The 2-Parameter Logistic (2PL) IRT model which is characterized by difficulty and discrimination item parameters is used to estimate the latent ability scores. Several datasets are generated for variety of sample size and item length values. The Monte-Carlo simulation is used to analyze the performance of the estimators. Results show that MLE produces reliable results with low root mean square error (RMSE) across all datasets. …

Differential Impacts Of Hhv-6a Versus Hhv-6b Infection In Differentiated Human Neural Stem Cells, Elham Bahramian

Graduate Theses and Dissertations

Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there areonly three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7. Initially, HHV-6A and HHV-6B were considered as two variants of the same virus (i.e., HHV6). Despite high overall genetic sequence identity (~90%), HHV-6A and HHV-6B are now recognized as two distinct viruses. Sequence divergence (e.g., >30%) in key coding regions and significant differences in physiological and biochemical profiles (e.g., use of different receptors for viral entry) underscores the conclusion that HHV-6A and HHV-6B are distinct viruses of the β-herpesvirinae. Despite these viruses being implicated as causative agents in …

A Study On Interactions Between Metal-Organic Frameworks And Biological Materials, Josh Phipps

Graduate Theses and Dissertations

Metal-organic frameworks or MOFs are an extremely useful tool in many areas of applications. Their popularity in recent years has arisen from their high efficiency in catalytic chemical reactions. This is made possible due to their porous interior and the ability of the MOFs components to be functionalized. These same traits make MOFs excellent for use in protein encapsulation or immobilization and have the potential to become excellent drug carriers. Their development in this utilization has been limited dramatically compared to MOFs chemical applications. This is due in part to the nature of biological processes taking longer to study, but …

A Comparison Of Student Final Grades In College Algebra Based On Face-To-Face And Online Course Modalities, Christopher Michael Lafata

Graduate Theses and Dissertations

As community colleges emerge from the COVID-19 pandemic there may be a tendency to rely on technology to facilitate more online coursework. Online education has been a fixture of higher education since the mid-1990s, but there’s always been a question as to whether it is effective as traditional, face-to-face coursework. This is especially important in College Algebra, already viewed as a barrier course for many students. If more students take College Algebra online, will the results be as good as students taking the course in a classroom? The purpose of this quantitative causal-comparative study is to identify the relationship between …

The Antimicrobial Resistance Plasmid Mobilome Of Salmonella Enterica And Related Enteric Species And Factors That Influence The Transfer Efficiency., Suad Algarni

Graduate Theses and Dissertations

The dynamic distribution of antimicrobial resistance genes in Salmonella enterica is considered a public health risk. S. enterica is one of the most important etiological agents of foodborne illness and has a critical impact on global human health. In S. enterica and related species, mobile genetic elements (MGEs) serve as primary vehicles for the dissemination of antibiotic resistance genes in the bacterial evolution. This dissemination can be impacted by different selective pressures that leads to diverse antibiotic response phenotypes. This project focusses on the dynamics of antimicrobial resistance genes, particularly exploring the transfer efficiency of multidrug resistance plasmids in S. …

A Case Study Examining Women In Leadership At A College Of Osteopathic Medicine, Sloane Gibson Kelley

Graduate Theses and Dissertations

Dr. Andrew Taylor Still, the founder of osteopathic medicine, actively promoted gender parity in the field from its inception, at a time when few medical schools accepted women into their programs, and even fewer all-female medical schools existed (Quinn, 2017; Simpson & Weiser, 1996). Although an almost equal number of male and female students are enrolled in osteopathic medical schools, men far outnumber women in positions of leadership. While the data for the number of women deans and department chairs at osteopathic medical schools does not exist, research by the Association of American Medical Colleges (2021) showed that 24% of …

Using Copper Oxide And Zwitterions To Prevent Membrane Fouling And Optimizing Ultrafiltration Membrane Fabrication With Green Solvents, Cannon Hackett

Graduate Theses and Dissertations

Membrane fouling and sustainable production of membranes are two of the most important challenges in membrane science. Chapter 1 of this dissertation introduces these challenges and covers previous research that has been done in those areas. Additionally, the objectives of this dissertation are stated. In chapter 2, a study was done in which polyethersulfone ultrafiltration membranes were functionalized with copper oxide nanoparticles and zwitterions for the purpose of reducing fouling on the membrane surface. Characterization confirmed the attachment of each component to the membranes. Dead-end filtration was performed with water and bovine serum albumin solution and showed that the functionalization …

Using Molecular Dynamics Simulations To Decipher Mechanistic Details Of Biomolecular Processes Of Biology And Biotechnology Oriented Applications, Adithya Polasa

Graduate Theses and Dissertations

Researchers in chemistry and biology often utilize computer simulations, in conjunction with experimental data, to model and predict the structures, energies, kinetics, processes, and functions of the systems that are their focus of study, ranging from single molecules to whole viruses. Here, we use molecular dynamics (MD) techniques to gain a deeper understanding of biomolecular processes in biology and biotechnology-oriented applications. Using a mixture of equilibrium and non-equilibrium MD simulations, this work describes the insertion process of YidC at the atomic level. In order to better comprehend the insertion process, several docking models of YidC-Pf3 in the lipid bilayer were …

Mitochondrial Functions Are Major Targets Of Isocyanide Activity In Saccharomyces Cerevisiae, Morgan A. Siemek

School of Biological Sciences: Dissertations, Theses, and Student Research

The isocyanide functional group is important in the synthesis of many organic compounds and is found in natural products produced by plants, bacteria, marine invertebrates, and fungi. The antimicrobial activities of isocyanide compounds have been documented for almost 70 years, however, the biochemical targets and mechanisms of action remain poorly defined. We report antimicrobial activity of 4-para-nitrophenyl-isocyanide (p-NPIC) against a model fungus, Saccharomyces cerevisiae, and the human fungal pathogen Candida albicans. To identify the cellular and molecular targets of p-NPIC, we screened the non-essential single gene-deletion collection of S. cerevisiae. We …

Household Size And Household Wealth In Indonesia With The Influence Of Spatial Aspects, Thomas Soseco

Economics and Finance in Indonesia

Investigating household wealth should also include spatial analysis to capture the influence of location on the households’ net wealth and to avoid underestimation of the effect of the change of variables due to estimation that ignores spatial aspects. This paper examines factors influencing household net wealth in Indonesia with the influence of spatial lag using data from the Indonesian Family Life Survey (IFLS) for 1993–2014. The article relies on the Spatial Durbin Model (SDM) to analyze the data. Results show that household net wealth in Indonesia is spatially related to each other, and the spillover effect makes the change of …

Segment-Wise Time-Varying Dynamic Bayesian Network With Graph Regularization, Xing Yang, Chen Zhang, Baihua Zheng

Research Collection School Of Computing and Information Systems

Time-varying dynamic Bayesian network (TVDBN) is essential for describing time-evolving directed conditional dependence structures in complex multivariate systems. In this article, we construct a TVDBN model, together with a score-based method for its structure learning. The model adopts a vector autoregressive (VAR) model to describe inter-slice and intra-slice relations between variables. By allowing VAR parameters to change segment-wisely over time, the time-varying dynamics of the network structure can be described. Furthermore, considering some external information can provide additional similarity information of variables. Graph Laplacian is further imposed to regularize similar nodes to have similar network structures. The regularized maximum a …

Does Mainstream Brca Testing Affect Surgical Decision-Making In Newly-Diagnosed Breast Cancer Patients?, Quratul Ain, Caroline Richardson, Miriam Mutebi, Angela George, Zoe Kemp, Jennifer E. Rusby

General Surgery, East Africa

Background: Germline pathogenic variants mutations) in the BRCA1 and BRCA2 genes cause an increased risk of breast cancer and ovarian cancer. Mainstream cancer genetic testing (MCG) was introduced for breast cancer patients in our unit in 2013. Non-geneticist clinicians have been trained to offer genetic testing during initial treatment planning. We assessed the impact of timely test results on surgical decision-making.

Methods: Women who had undergone mainstream genetic testing for breast cancer between September 2013 and September 2018 were identified from a prospective database. Surgical data were collected retrospectively.

Results: 580 eligible women had mainstream genetic testing. …

Employment Transitions From Active-Duty Army Officer To Civilian: An Exploration Of The Knowledge, Skills, And Abilities Possessed By Combat-Experienced, Army Field-Grade Officers, James Daniel Crook

Theses and Dissertations

Two decades of wars in Iraq and Afghanistan have concluded, bringing an end to the longest military conflicts in the history of the United States of America. Following the example of post-war history, the military’s posture is to reduce personnel end-strength. The post-war military requires fewer soldiers, and a significant number of transitioning officers make the journey from military to civilian employment. This quantitative study discovered the knowledge, skills, and abilities of combat-experienced, active-duty, Army field-grade officers and explored the change from military to civilian employment. This study addressed the gap in the literature regarding this specific group of transitioning …

Deep Learning Approach To Speech Recognition: A Signal Extractor & Producer For Artificial General Intelligence, Ahmad Zuhair S. Hasanain

Theses and Dissertations

The efficient use of a communication bandwidth starts with the data source. The features of the speech signals can be extracted and reconstructed to lower the Internet traffic of the acoustic artificial agents and to increase the quality of the automatic speech recognition systems. The Speech Quefrency Transform (SQT) is hereby introduced in the work to enrich the communication space between the artificial agents and mankind. We describe the motivation, methodology, and deep learning approach in detail as we apply the SQT technology to several applications: sharp pitch track extraction, real-time speech communications, and emotion recognition. The results were excellent. …

Non-Negative Matrix Factorization In The Identification Of Co-Mutations, Michael Robert Kolar

Theses and Dissertations

One of the difficulties of genetic research is the asymmetrical relationship between data collection techniques and data analysis techniques. The goal of this research was to test a novel application of non-negative matrix factorization, which would allow researchers to more easily identify co-mutations. Those co-mutations then can then be further verified by frequency analysis. This pruning process allows researchers to identify more fruitful research opportunities, saving time, energy, and funding. Past research has utilized non-negative matrix factorization to extract factors which meaningfully express underlying data features. This study extends the depth of non-negative matrix factorization knowledge in various ways. First, …

The Effect Of Zonation, Biofouling, And Corrosion Products On Cathodic Protection Design For Offshore Monopiles, Caglar Erdogan

Theses and Dissertations

Cathodic protection (CP) is required to prevent corrosion of the submerged steel for offshore wind monopile foundations in the marine environment. The design of these systems depends on the environmental conditions, including temperature, salinity, pH, dissolved oxygen, depth, micro- and macro-organisms, and water flow rates. The standards utilized to design cathodic protection systems consider only some of these conditions. This research identified the gaps in knowledge for the design of corrosion prevention systems for offshore wind monopile foundations and investigated the changes in cathodic current densities due to macro-galvanic cells, fouling communities and corrosion products established on uncoated vertical steel …

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Criterion: A Journal of Literary Criticism

No abstract provided.

Fragments And Foreignness In Claudia Rankine's Citizen, Cutter Mendenhall

Criterion: A Journal of Literary Criticism

This analysis investigates Claudia Rankine’s redefinition of foreignness as the fragmenting force of microaggressions that splinters the African American identity. This fragmentation has implications that shatter and reconstruct the traditional understanding of the African American self, the source and fallacies of both white and black anger, and what it means to be native to mainstream American society. Ultimately, Rankine asserts that the foreignizing nature of microaggressions is a socially constructed form of oppression. This foreignness breaks the African American identity into easily accessible subhuman caricatures that leave the black identity in a ruptured state of cognitive dissonance. While making coherence …

Forest Structure And Composition Alleviate Human Thermal Stress, Loïc Gillerot, Dries Landuyt, Rachel Oh, Winston T. L. Chow, Et Al

Research Collection College of Integrative Studies

Current climate change aggravates human health hazards posed by heat stress. Forests can locally mitigate this by acting as strong thermal buffers, yet potential mediation by forest ecological characteristics remains underexplored. We report over 14 months of hourly microclimate data from 131 forest plots across four European countries and compare these to open-field controls using physiologically equivalent temperature (PET) to reflect human thermal perception. Forests slightly tempered cold extremes, but the strongest buffering occurred under very hot conditions (PET >35°C), where forests reduced strong to extreme heat stress day occurrence by 84.1%. Mature forests cooled the microclimate by 12.1 to …

Heat And Colonial Weather Science In The Straits Settlements C. 1820-1900, Fiona Williamson

Research Collection College of Integrative Studies

Historical explorations of tropical heat in a colonial context have largely focussed on two interconnected spheres: colonial perceptions of place and body or, the implications of heat on different bodies in medical thought and practice. This paper seeks to move the discussion towards a history of colonial scientific thought about heat as component of weather and of escalating nature-induced hazards, studied in the observatory or meteorological department. A central theme is to think about heat in its relationship to nascent meso-scale atmospheric knowledge, meteorological theory and, as a by-product of urbanisation and land-use change. In so doing, it conceptualises the …

A New Feudalism: Selfish Genes, Great Wealth, And The Rise Of The Dynastic Family Trust (Dft), Eric Kades

Faculty Publications

Today’s record levels of economic inequality are infecting our future as the top 0.01% bequeath vast wealth to their descendants. With the death of the Rule Against Perpetuities (RAP), this inequality has the potential to harden social class lines—not just for a generation or two, but forever. Although it may sound implausible, interviews with estate lawyers serving very high-net-worth clients reveal that some members of the wealthiest tier of testators are already exploiting the RAP’s elimination, along with a tax loophole, to establish dynasty trusts that will financially empower their bloodline as long as it continues. Recent work in evolutionary …

A Comparison Of The Mental Health Of Police Officers And Correctional Officers In Rural Appalachia, Sierra Thomas

Electronic Theses and Dissertations

The purpose of this study was to explore perceptions of mental health among police officers and correctional officers within rural Appalachia. The main goal of this research was to better understand how the occupational demands of working in the criminal justice field can impact one’s mental health over time. Several research questions were explored, including the prevalence of various mental health problems, associated stressors, the structure of support among officers, and the perceptions of mental health treatment services. Data were gathered through semi-structured interviews with 21 police and correctional officers located in rural Appalachia. Results provided a better understanding of …

Low-Dose Aspirin For Venous Thromboembolism Prophylaxis Is Associated With Lower Rates Of Periprosthetic Joint Infection After Total Joint Arthroplasty, Farideh Najafi, Joseph K. Kendal, Nicholas V. Peterson, Kerri-Anne Ciesielka, Camilo Restrepo, Javad Parvizi, Nicholas M. Bernthal

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Aspirin as a venous thromboembolism (VTE) prophylactic agent has been shown to have antistaphylococcal and antibiofilm roles. Optimal acetylsalicylic acid (ASA) dosage would facilitate antimicrobial effects while avoiding over-aggressive inhibition of platelet antimicrobial function. Our purpose was to determine the periprosthetic joint infection (PJI) rate after total joint arthroplasty in patients receiving low-dose ASA (81 mg twice a day), in comparison to high-dose ASA (325 mg twice a day).

METHODS: We conducted a retrospective cohort study between 2008 and 2020. Eligible patients were older than 18 years, underwent primary total joint arthroplasty, both total knee arthroplasty and total hip …

South Texas Wildlife Activity Across A Fragmented Landscape And Road Mitigation Corridor, Caitlin K. Brett

Theses and Dissertations

Wildlife crossing structures (WCS) and roadside fencing are commonly installed to mitigate habitat fragmentation, wildlife road mortalities, and other negative effects that roads can have on the surrounding landscape. Eight such WCS were constructed below Farm-to-Market (FM)106 in Cameron County, Texas, across a 16 km corridor transecting the Laguna Atascosa National Wildlife Refuge. These WCS, paired with adjacent roadside fencing, were intended to prevent road mortalities of the endangered ocelot (Leopardus pardalis) and to mitigate the barrier effect of FM106 on this and other meso-mammal species. This study will analyze camera trap data from roadside and habitat reference …

Grapefruit Peel Biochar Applications For Immobilizing Copper And Lead In Soil, Michael Alfredo Navarro

Theses and Dissertations

This study investigated the efficacy of grapefruit peel (GP) derived biochar materials (two pyrolysis temperatures 450°C and 800°C) as a potential adsorbent to immobilize heavy metal (copper and lead) in a local sandy loam clay soil. A batch adsorption test with heavy metal concentrations at 50 mg L-1, and 100 mg L-1 revealed that soil itself had the highest immobilization percentage compared to the GP biochars. A soil column experiment was conducted to determine how much the GP biochar samples and the tested soil will exhibit adsorptive characteristics for heavy metals when 50 ml of 50 mg L-1 copper or …

Synthesis Of Bioactive Heterocycles, Shaila Akter Shetu

Theses and Dissertations

The Discovery of a variety of heterocyclic drugs for the treatment of cancer and other diseases (e.g, neglected tropical diseases) is a medical breakthrough and inspiring for the research community as a whole. A wide range of natural, semi-synthetic, and synthetic anticancer drugs are synthesized using various methods. Among them, β -lactams stand out as a novel class of antibiotics that has different types of biological as well as anti-cancer properties. β -lactam has become a premier and active research subject towards the development of revolutionary anti-cancer drugs. In recent years, a large amount of investigations have been done to …

Cost Utility Of Supporting Family-Based Care To Prevent Hiv And Deaths Among Orphaned And Separated Children In East Africa: A Markov Model–Based Simulation, Marta Wilson-Barthes, Paula Braitstein, Allison Delong, David Ayuku, Lukoye Atwoli, Edwin Sang, Omar Galárraga

Internal Medicine, East Africa

Purpose: Strengthening family-based care is a key policy response to the more than 15 million orphaned and separated children who have lost 1 or both parents in sub-Saharan Africa. This analysis estimated the cost-effectiveness of family-based care environments for preventing HIV and death in this population.

Design: We developed a time-homogeneous Markov model to simulate the incremental cost per disability-adjusted life year (DALY) averted by supporting family-based environments caring for orphaned and separated children in western Kenya. Model parameters were based on data from the longitudinal OSCAR’s Health and Well-Being Project and published literature. We used a societal perspective, …

Seeing The Big Picture: System Architecture Trends In Endoscopy And Led-Based Hyperspectral Subsystem Intergration, Craig M. Browning

Graduate Theses and Dissertations (2019 - present)

Early-stage colorectal lesions remain difficult to detect. Early development of neoplasia tends to be small (less than 10 mm) and flat and difficult to distinguish from surrounding mucosa. Additionally, optical diagnosis of neoplasia as benign or malignant is problematic. Low rates of detection of these lesions allow for continued growth in the colorectum and increased risk of cancer formation. Therefore, it is crucial to detect neoplasia and other non-neoplastic lesions to determine risk and guide future treatment. Technology for detection needs to enhance contrast of subtle tissue differences in the colorectum and track multiple biomarkers simultaneously. This work implements one …

Alfred Russel Wallace Notes 24. Wallace At 200: Potential Subjects For Student Theses, Charles H. Smith

Faculty/Staff Personal Papers

The bicentennial of Alfred Russel Wallace’s birth in 2023 will likely produce a wide array of reviews of his life and work; here, we pause for a short look at some Wallace-related questions that might be adapted for student theses and dissertations. Some of the subjects treated fall in with established lines of research, while others are suggested by other Wallace interests or activities that have not been much explored.

Alfred Russel Wallace Notes 23: The Jersey Devil, And Friends, Charles H. Smith

Faculty/Staff Personal Papers

For nearly three hundred years reports have surfaced of a purported cryptid form known as the ‘Jersey devil.’ In this work an interpretation of the goals of biogeography is given, and how this field can be related to such alleged phenomena, as well as to some of the ideas of Alfred Russel Wallace (1823-1913) that seem to find their origin in the writings of Benedict de Spinoza (1632-1677).