Digital Commons Network^™

Medical Harm Without Negligence, Valerie Gutmann Koch

Fordham Law Review

In December 2019, seven women from one family underwent highly invasive surgeries based on genetic test results that indicated that each were at significant risk of developing cancer by age seventy. Subsequently, after procedures that (among other things) permanently scarred and disfigured their bodies and ended their chances of having biological children, they learned that their particular mutation was not, in fact, pathogenic.

This Article focuses on a previously under-recognized problem: what happens when a patient’s previously classified pathogenic variant is downgraded to uncertain (or even benign) status? Intuitively, it might seem that the genetic testing company, the surgeons, or …

Intersections Of Gender And Age: Identification And Attributional Processes On Leadership Effectiveness, Kayla Lynne Bigerton

Theses and Dissertations

As more women enter leadership roles and the ages of leaders becomes more diverse, there is a need for more intersectional research. An intersectional approach was used to assess the impact of leader gender and age on leadership effectiveness through identification and attributional processes. In doing so, different age conceptualizations were also examined. Gender did not have an impact on identification and attributional processes and age had mixed results. Age similarity was not significantly related to leader identification, but perceived leader age had a negative relationship with idiosyncratic fit. Further, social age was examined with different age ranges representing "young”, …

Enhancing Motor Imagery Decoding Via Transfer Learning, Olawunmi George, Sarthak Dabas, Abdur Sikder, Roger Smith, Praveen Madiraju, Nasim Yahyasoltani, Sheikh Iqbal Ahamed

Computer Science Faculty Research and Publications

Motor imagery (MI) is arguably one of the most common brain–computer interface (BCI) paradigms. The decoding process, in many cases, involves the use of small amounts of data gathered over a period. The decoding performance might therefore be limited, due to the size of available data. Also, the non-stationarity of signals across sessions and subjects can pose a challenge to effective decoding. To solve these challenges, transfer learning is proposed as the suitable approach, which could yield optimal performance even with small amounts of data and handle the non-stationarity of signals with adaptation. It has been applied across domains and …

Application Of Stable Isotopes To Study Movement Ecology And Diet Variation In A Migratory Songbird, Andrea Contina, Allison K. Pierce, Scott W. Yanco, Eli S. Bridge, Jeffrey F. Kelly, Michael B. Wunder

School of Integrative Biological & Chemical Sciences Faculty Publications

Whether and how migratory organisms exhibit interindividual behavioral and/or physiological variation across movement strategies remains an open question. The Dark-eyed Junco (Junco hyemalis) is a migratory songbird known for its intraspecies variation displayed in relation to morphology, song repertoires, and migration. Thus, studies focusing on juncos can reveal how migratory strategy may covary with other individual-scale factors and, therefore, identify the selective forces driving intraspecies variations throughout its distribution. We used Dark-eyed Junco hydrogen stable isotope feather values (δ²H) and implemented a Bayesian framework to infer the breeding and molting origin of migratory juncos captured on their winter grounds in …

Characterizing The Cutaneous Microbiome Of Eurycea Lucifuga As A Potential Defense Against Chytridiomycosis, Madeline Key

Senior Honors Theses

Chytridiomycosis is an emerging infectious disease that is significantly reducing global amphibian populations. The disease is caused by Batrachochytrium dendrobatidis (Bd), a fungus that lethally modifies amphibian skin. Recent research has suggested that the cutaneous microbiome of individual amphibians may play a role in susceptibility to the pathogen. In this study, twelve cave salamanders (Eurycea lucifuga) were collected. Cutaneous bacteria from each salamander were isolated and identified using Sanger Sequencing. Additionally, a Bd-challenge assay was performed to determine each isolate’s antifungal activity. Results indicated many microbial isolates possessed inhibitory capabilities against Bd, which may …

Worried Sick: Understanding The Implications Of Stress On A Physiological Level, Julia Saia

Senior Honors Theses

Stress is prevalent among many individuals in today’s society. A literature review was conducted to investigate the physiological effects of stress, including the biomarkers of stress and how these interact with various body systems. The stress response is a protective mechanism to prepare the body to adequately respond to a perceived threat. However, when this response is prolonged, it begins to have a maladaptive effect on the body and can cause more harm than good. This literature review sought to compile what is known regarding the general effects of chronic stress and its impact on the nervous, immune, digestive, and …

The Importance And Implementation Of Kinesthetic Learning In The English Classroom, Emma Crandall

Senior Honors Theses

This paper examines different educators’ and researchers’ activities for kinesthetic learners and discusses how they can be applied to the English classroom in literature, writing, and language. The first section delves into the difficulty associated with but ultimate importance of including kinesthetic learning activities for both kinesthetic and non-kinesthetic learners due to the benefits of active learning. Subsequently, it looks for synthesis between different types of kinesthetic activities, dividing them into the categories of manipulatives, commonly accepted classroom activities with kinesthetic add-ons, and kinesthetic-centered activities. The ways each activity can be used, including its benefits and disadvantages, are discussed, and …

Creating A Culture Of Learning: Intrinsic Motivation And Its Practical Value In The Wake Of The Covid-19 Pandemic, Paige Hennen

Senior Honors Theses

In the wake of the COVID-19 pandemic, students of all ages were required to rapidly transition to the demands of virtual learning, resulting in general amotivation. These changes have led to poor academic performance, due to the decreased efficiency of learning processes as these students learn to cope with the instability caused by the pandemic as well as school-related changes. Intrinsic motivation, especially when cultivated within the learning process, plays an important role in student academic success and acts as an influence on holistic success in adulthood. Thus, educators must cater to the needs of this generation's students by implementing …

The Greatest Teacher: Modeling Jesus In Urban Education, Harley Rusk

Senior Honors Theses

Several key best practices from urban education research are reflected in the pedagogy of Jesus Christ, providing a practical foundation for Christian educators in urban schools. Related to the prevalence of poverty and trauma are the practices of learning students’ backgrounds to better interpret behavior, which Jesus reflects by healing before teaching, and holding high standards, demonstrated in Jesus’ interaction with the rich man and the Sermon on the Mount. Related to racial diversity are the practices of addressing implicit bias, a crucial part of being Christlike, and connecting instruction to students’ culture, like Jesus did through parables. Christians can …

The Effect Of Video Model Dosage And Self-Monitoring On Parent's Use Of Language-Promoting Behavior, Kacie Marie Mcgarry

Theses and Dissertations

Previous research has found a disparity between the language trajectories of children within a high, medium, or low-economic-status family. A relationship is reliably found between the language trajectory of toddlers and success throughout school. This study will evaluate a training package to teach parents to engage in behaviors that promote language and assess the training's short-term effect on the trajectories of children (i.e., growing language) within low-socioeconomic backgrounds. Specifically, experimenters will evaluate the impact of the dosage of video modeling, self-evaluation, and self-monitoring on the acquisition of the targeted skills. Data may suggest that the more accurate the individual is …

The Solution-Focused Circle Technique: A Visual Tool For Discovering Strengths And Facilitating Change In Therapy And Counseling, Arnoud Huibers, Ben Furman

Journal of Solution Focused Practices

The Circle Technique is a solution-focused tool for discovering clients' resources, competencies and desired changes, essential aspects of solution-focused psychology. Using two concentric circles, the practitioner guides the client to find resources and ideas about what they want to change and solutions they can use within their social context. The visual tool allows the practitioner and the client to act as explorers, like Marco Polo or Columbus, discovering new worlds. The Circle Technique can be applied in diverse settings to empower a wide range of clients to find valuable ideas. The information found with the help of the circles feels …

Performance Comparison Of Weak And Strong Learners In Detecting Gps Spoofing Attacks On Unmanned Aerial Vehicles (Uavs), Aydan Gasimova

Theses and Dissertations

Unmanned Aerial Vehicle systems (UAVs) are widely used in civil and military applications. These systems rely on trustworthy connections with various nodes in their network to conduct their safe operations and return-to-home. These entities consist of other aircrafts, ground control facilities, air traffic control facilities, and satellite navigation systems. Global positioning systems (GPS) play a significant role in UAV's communication with different nodes, navigation, and positioning tasks. However, due to the unencrypted nature of the GPS signals, these vehicles are prone to several cyberattacks, including GPS meaconing, GPS spoofing, and jamming. Therefore, this thesis aims at conducting a detailed comparison …

An Indepth Look On Earth-Anchoring Through Architectural Treatments To Mitigate Psychological And Psychosocial Issues During Long-Duration Spaceflight, Skye Elizabeth Schwartz

Theses and Dissertations

Astronauts' mental health is of significant concern for any spaceflight mission. For low-Earth orbit (LEO) spaceflights, crews are four to six hours away from home. They can still see planet Earth, and if there is an emergency, there are escape routes; however, when it comes to long-duration spaceflights millions of miles away from home, crews cannot see planet Earth, cannot turn around in an emergency and are on their own in a monotone and sterile environment. These desensitizing conditions directly impact astronauts’ psychological and psychosocial well-being. Crews must learn how to interact with each other for an extended period, considering …

Raising Native Plant Awareness As A Method For Re-Naturalization, Meredith L. Haaker

Social Sciences

Humans are inseparable from the natural environment. We are one and the same, interconnected within the ecology of creation and care, not only destruction. By grounding ourselves in Indigenous wisdom and the principles of Traditional Ecological Knowledge, we are more able to recognize the important relational facets between humans and three native Californian plants (California black walnut, California blue elderberry, California bay laurel). In introducing Kimmerer’s concept of re-naturalization of humans, we can draw a connection to the same process a naturalized plant undergoes; immigration from a foreign place, dependence on the surrounding resources, and settlement of an area …

Medical Education And Population Health—A Framework In The Design Of A New Undergraduate Program, Robert Armstrong, Michaela Mantel, Gijs Walraven, Lukoye Atwoli, Anthony Ngugi

Internal Medicine, East Africa

Health sciences curricular planners are challenged to add new content to established education programs. There is increasing pressure for content in public health, health systems, global health, and planetary health. These important areas often compete for curricular time. What is needed is a convergence model that builds a common framework within which students can integrate areas and better align this knowledge to the individual client or patient who they have responsibility to support. A population health framework is proposed for health sciences education programs that supports a common conceptual understanding of population health. The framework links five thematic areas that …

Spatial Response Of Bobcats And Coyotes To Resources And Human Modification In Illinois, Nicole Gorman

Theses

Mesocarnivores, including bobcats (Lynx rufus) and coyotes (Canis latrans), fill a unique ecological role throughout much of North America, where they were once influenced by larger predators, but are now the top predators where large carnivores have been extirpated. Their adaptability, generalist traits, and ability to coexist with humans to a greater extent than many species makes them an important subject for current predator research. In addition, their recent population recovery in the case of bobcats and historical range expansion in the case of coyotes make their study timely given a potential increase in their influence on their prey and …

Tracing The Roots Of Resistance, Collective Action And Solidarity Among Igbo Women, Sebastian Ukoh

Theses

Most societies have always achieved balance through some internal mechanisms. Achieving gender balance and drawing lines without letting what we may term the "stronger sex" domineer the "weaker sex" is not always easy. Among the Igbos of South Eastern Nigeria, the women have always pressed home their demands without fear. We will be looking at how they have done this for more than a century, especially at the onset of the British colonial enterprise.

Color Resolved Cherenkov Imaging Allows For Differential Signal Detection In Blood And Melanin Content, Vihan A. Wickramasinghe

Dartmouth College Master’s Theses

Cherenkov imaging in radiation therapy allows a video display of the irradiation beam on the patient’s tissue, for visualization of the treatment. High energy radiation from a linear accelerator (Linac) results in the production of spectrally-continuous broadband light inside tissue due to the Cherenkov effect; this light is then attenuated by tissue features from transport and exits from the delivery site. Progress with the development of color Cherenkov imaging has opened the possibility for some level of spectroscopic imaging of the light-tissue interaction and interpretation of the specific nature of the tissue being irradiated. Generally, there is a linear relationship …

Clinical And Demographic Factors Contributing To Asparaginase-Associated Toxicities In Children With Acute Lymphoblastic Leukemia, Priyadarshani Dharia, Michael D Swartz, M Brooke Bernhardt, Han Chen, M Monica Gramatges, Philip J Lupo, Austin L Brown, Michael E Scheurer

Center for Medical Ethics and Health Policy Staff Publications

A total of 548 patients (age range: 1-22 years, 60.4% Hispanic, 55.8% male) diagnosed with acute lymphoblastic leukemia were reviewed for pegaspargase-associated hypersensitivity (14.8%), hyperbilirubinemia (9.7%), venous thromboembolism (VTE, 9.7%), and pancreatitis (5.3%). Odds ratios (OR) and 95% confidence intervals (CI) evaluated associations between clinical factors and each toxicity, cumulative number of toxicities, and toxicity clusters identified using k-mode analysis. Most (68.9%) did not experience any toxicity, 24.6% experienced one toxicity, and 6.3% two or more. Age >10 years was associated with hyperbilirubinemia (OR = 3.83; 95% CI: 1.64-8.95), pancreatitis (OR = 3.72; 95% CI: 1.29-10.68), VTE (OR = 4.65; …

Social Networks, High-Risk Anal Hpv And Coinfection With Hiv In Young Sexual Minority Men, Kayo Fujimoto, Alan G Nyitray, Jacky Kuo, Jing Zhao, Lu-Yu Hwang, Elizabeth Chiao, Anna R Giuliano, John A Schneider, Aditya Khanna

Faculty, Staff and Student Publications

OBJECTIVES: Young sexual minority men (SMM) exhibit a high prevalence and incidence of high-risk genotypes of human papillomavirus (hrHPV) anal infections and a confluence of a high prevalence of HIV and rectal STIs. Social determinants of health (SDOHs) are linked to social network contexts that generate and maintain racial disparities in HIV and STIs. A network perspective was provided to advance our knowledge of drivers of genotype-specific hrHPV infection and coinfection with HIV. The study also examined whether socially connected men are infected with the same high-risk HPV genotypes and, if so, whether this tendency is conditioned on coinfection with …

Incidence Of An Insulin-Requiring Hyperglycemic Syndrome In Sars-Cov-2-Infected Young Individuals: Is It Type 1 Diabetes?, Massimo Pietropaolo, Peter Hotez, Nick Giannoukakis

Center for Medical Ethics and Health Policy Staff Publications

Pancreatic ACE2 receptor expression, together with increased prevalence of insulin-requiring hyperglycemia in patients with coronavirus disease 2019 (COVID-19), suggested that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pancreatic infection might trigger a β-cell-selective inflammation precipitating autoimmune type 1 diabetes (T1D). We examined T1D incidence in patients with COVID-19 inside a large, global population using a "big data" approach. The incidence in 0-30-year-old patients with confirmed COVID-19 over an ∼15-month period from the beginning of the COVID-19 pandemic was compared with an age-matched population without COVID-19 inside the TriNetX COVID-19 Research Network (>80 million deidentified patient electronic medical records globally). …

Evaluating Deep Learning Explanations On Risc-V Assembly As A Reverse Engineering Aid, Daniel F. Koranek

Theses and Dissertations

This dissertation addresses several problems surrounding the detection of malware using deep learning models trained on assembly language examples. First, it examines the feasibility of detecting examples of malice using deep learning models trained on RISC-V instruction traces. Next, it examines whether models for detecting trace features and code features in RISC-V assembly can be made explainable (providing rationale for a model’s decision based upon the model’s internal workings) or interpretable (providing additional rationale as model output to support a human’s agreement with the model output). Third, this work examines ways in which it is possible to give additional contextual …

Characterization Of Enhancer Fragments In Drosophila Robo2, Gina Hauptman, Marie C. Reichert, Muna A. Abdal Rhida, Timonthy A. Evans

Biological Sciences Faculty Publications and Presentations

Receptor proteins of the Roundabout (Robo) family regulate axon guidance decisions during nervous system development. Among the three Drosophila robo family genes (robo1, robo2 and robo3), robo2 displays a dynamic expression pattern and regulates multiple axon guidance outcomes, including preventing midline crossing in some axons, promoting midline crossing in others, forming lateral longitudinal axon pathways, and regulating motor axon guidance. The identity and location of enhancer elements regulating robo2’s complex and dynamic expression pattern in different neural cell types are unknown. Here, we characterize a set of 17 transgenic lines expressing GAL4 under the control of DNA sequences derived …

Evaluating The Viscoelastic Properties Of Alligator Skin Gelatin, Alligel, Compared To Mammalian And Fish Gelatins, Sarah E. Jimenez

Honors Capstones

No abstract provided.

Us Scientific Leadership Addressing Energy, Ecosystems, Climate, And Sustainable Prosperity: Report In Brief From The Berac Subcommittee On International Benchmarking, Maureen Mccann, Patrick Reed, Ana Alonso, Ludmilla Aristilde, Massie S. Ballon, Crysten Blaby, Allison A. Campbell, Kenneth James Davis, Brian H. Davison, Ben Evans, Robert F. Fischetti, Serita D. Frey, Ann M. Fridlind, Efi Foufoula-Georgiou, Ramon Gonzalez, Michael N. Gooseff, Nathan Hillson, Janet Jansson, Klaus Keller, Markus Kleber, Costas Maranas, Gerald A. Meehl, Himadri Pakrasi, Jennifer Pett-Ridge, Kristala Prather, Johannes Quaas, G. Philip Robertson, Alistair Rogers, Tim Scheibe, Thomas R. Schneider, Gary Stacey, Margaret S. Torn, Kerstin Kleese Van Dam, Detlef Vuuren, John Weyant, Stan Wullschleger, Shaocheng Xie, Seung Yon (Sue) Rhee, Huimin Zhao

Faculty Publications

This document presents the subcommittee’s overarching and domain-specific findings and recommendations for the next decade, identified by consensus across the full BERAC subcommittee and experts interviewed for this assessment.

Machine Learned Daily Life History Classification Using Low Frequency Tracking Data And Automated Modelling Pipelines: Application To North American Waterfowl, Cory Overton, Michael Casazza, Joseph Bretz, Fiona Mcduie, Elliott Matchett, Desmond Mackell, Austen Lorenz, Andrea Mott, Mark Herzog, Josh Ackerman

Faculty Research, Scholarly, and Creative Activity

Background: Identifying animal behaviors, life history states, and movement patterns is a prerequisite for many animal behavior analyses and effective management of wildlife and habitats. Most approaches classify short-term movement patterns with high frequency location or accelerometry data. However, patterns reflecting life history across longer time scales can have greater relevance to species biology or management needs, especially when available in near real-time. Given limitations in collecting and using such data to accurately classify complex behaviors in the long-term, we used hourly GPS data from 5 waterfowl species to produce daily activity classifications with machine-learned models using “automated modelling pipelines”. …

The Flavor Profiles Of Highland Barley Fermented With Different Mushroom Mycelium, Kai Wang, Cuicui Yang, Ziyan Dai, Zhenxiang Wen, Yin Liu, Xi Feng, Ying Liu, Wen Huang

Faculty Research, Scholarly, and Creative Activity

Highland barley was fermented with Cordyceps militaris, Stropharia rugoso-annulata, Morchella esculenta, Schizophyllum commune and Tremella sanguinea. The flavor profiles were investigated by electronic nose (E-nose), headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS) and sensory evaluation by train panel. Fermentation with mushroom mycelium was able to change the aroma profile of highland barley. The original strong grassy taste was reduced due to a decrease in hexanal, decanal and 2-pentylfuran, and new aromatic flavors (floral, sweet and mushroom fragrance) were acquired after fermentation. The overall flavor of the fermented highland barley varied with mushroom strains. Schizophyllum commune gave a heavier sour taste …

Analysis Of Volatile Compounds In Jinhua Ham Using Three Extraction Methods Combined With Gas Chromatography–Time-Of-Flight Mass Spectrometry, Dengyong Liu, Cong Yang, Lu Bai, Xi Feng, Yanping Chen, Yin Zhang, Yuan Liu

Faculty Research, Scholarly, and Creative Activity

The volatile compounds in Jinhua ham samples after different aging times were characterized using solvent-assisted flavor evaporation (SAFE), solid-phase microextraction (SPME), and needle trap (NT) extraction methods combined with gas chromatography–time-of-flight mass spectrometry (GC–TOF/MS). Hundreds of aroma compounds were identified, including aldehydes, alcohols, ketones, furans, esters, acids, pyrazines, and sulfides. The results showed that NT extracted the greatest number of volatile compounds, whereas the extraction efficiency of SPME headspace adsorption was highest among the three sample preparation methods. Principal component analysis of SPME effectively distinguished the variation in the aroma of the Jinhua hams specific to aging time. Butyrolactone, 2,6-dimethylpyrazine, …

Understanding And Targeting The Immunosuppressive Tumor Microenvironment, Li Cai, Li Cai

Dissertations and Theses (Open Access)

Immune checkpoint inhibitors (ICIs), such as anti-PD1/PD-L1 and anti-CTLA-4, have shown impressive antitumor efficacy by improving the activity of T cells. While these inhibitors work in many patients with various cancer types, they have minimal or no effect in many more patients. Mounting evidence indicates that, besides current known immune checkpoints, other immunosuppressive components in the tumor microenvironment (TME) need to be targeted to elicit the full immune responses.

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immunosuppressive myeloid cells that are involved in cancer progression and therapeutic resistance. In this work, we demonstrated the essential role of MDSCs …

Redox Sensing By Yeast Hsp70 Facilitates Modulation Of Protein Quality Control And The Cytoprotective Response, Alec Santiago

Dissertations and Theses (Open Access)

Neurodegenerative disease affects millions of Americans every year, through diagnoses such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. One factor linked to formation of these aggregates is damage sustained to proteins by oxidative stress. Cellular protein homeostasis (proteostasis) relies on the ubiquitous Hsp70 chaperone family. Hsp70 activity has been previously shown to be modulated by modification of two key cysteines in the ATPase domain by oxidizing or thiol-modifying compounds. To investigate the biological consequences of cysteine modification on the Hsp70 Ssa1 in budding yeast, I generated cysteine null (cysteine to serine) and oxidomimetic (cysteine to aspartic acid) mutant variants of both …