Digital Commons Network^™

A Summary Of The Inaugural Who Classification Of Pediatric Tumors: Transitioning From The Optical Into The Molecular Era., Stefan M Pfister, Miguel Reyes-Múgica, John K C Chan, Henrik Hasle, Alexander J Lazar, Sabrina Rossi, Andrea Ferrari, Jason A Jarzembowski, Kathy Pritchard-Jones, D. Ashley Hill, Thomas S Jacques, Pieter Wesseling, Dolores H López Terrada, Andreas Von Deimling, Christian P Kratz, Ian A Cree, Rita Alaggio

Pathology Faculty Publications

Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often originating from a single genetic driver event. The specific diagnostic challenges of childhood tumors led to the development of the first World Health Organization (WHO) Classification of Pediatric Tumors. The classification is rooted in a multilayered approach, incorporating morphology, IHC, and molecular characteristics. The volume is organized according to organ sites and provides a single, state-of-the-art compendium of pediatric tumor types. A special emphasis was placed on "blastomas," which variably recapitulate the morphologic maturation of organs from …

Host Tissue Proteomics Reveal Insights Into The Molecular Basis Of Schistosoma Haematobium-Induced Bladder Pathology., Derick N M Osakunor, Kenji Ishida, Olivia K Lamanna, Mario Rossi, Louis Dwomoh, Michael H. Hsieh

Urology Faculty Publications

Urogenital schistosomiasis remains a major public health concern worldwide. In response to egg deposition, the host bladder undergoes gross and molecular morphological changes relevant for disease manifestation. However, limited mechanistic studies to date imply that the molecular mechanisms underlying pathology are not well-defined. We leveraged a mouse model of urogenital schistosomiasis to perform for the first time, proteome profiling of the early molecular events that occur in the bladder after exposure to S. haematobium eggs, and to elucidate the protein pathways involved in urogenital schistosomiasis-induced pathology. Purified S. haematobium eggs or control vehicle were microinjected into the bladder walls of …

Understanding The Impact Of Fat10 Overexpression On Liver Metabolism, Sharifa Love-Rutledge, Lauren Richardson

Summer Community of Scholars (RCEU and HCR) Project Proposals

No abstract provided.

Pathology, Identity, Or Both?: Making Meaning From Early Christian Martyrdom, Matthew J. Recla

University Author Recognition Bibliography: 2022

Partly in response to an earlier ‘pathological approach’ that seemingly stigmatised early Christian martyrdom, recent scholarship has adopted an ‘identity approach’ that explains martyrdom as a normative discourse of self-construction. This explanation of martyrdom as Christian identity-making, not willing death, is insufficient for three reasons. First, this approach implicitly reaffirms the theological claim that religious identity alone makes martyrs. In doing so it reduces the complexity of the individual martyr to ‘Christian’. Second, this approach excises the existential phenomenon of the martyr from martyrdom. Third, the term ‘identity’ has become ubiquitous, and its use to mark both sameness and difference …

Sex-Related Differences In Aging Rate Are Associated With Sex Chromosome System In Amphibians, Hugo Cayuela, Beth Reinke, 48 Other Co-Authors

Biology Faculty Publications

Sex-related differences in mortality are widespread in the animal kingdom. Although studies have shown that sex determination systems might drive lifespan evolution, sex chromosome influence on aging rates have not been investigated so far, likely due to an apparent lack of demographic data from clades including both XY (with heterogametic males) and ZW (heterogametic females) systems. Taking advantage of a unique collection of capture–recapture datasets in amphibians, a vertebrate group where XY and ZW systems have repeatedly evolved over the past 200 million years, we examined whether sex heterogamy can predict sex differences in aging rates and lifespans. We showed …

The Effect Of Pain Tolerance On Healthcare Utilization Among Patients With Chronic Pain, Callie Rose Teufert

Theses and Dissertations

Chronic pain patients are more likely to use healthcare services and have greater expenditures related to health needs, which has led to studies on different aspects of pain that may lead to greater use, disability, functional impairment, and other outcomes. Factors that have been researched for their potential relationships with healthcare utilization (HCU) in various populations include function loss, pain catastrophizing, anxiety, fear, pain severity, and pain duration. Pain tolerance has not been extensively studied for its impact on healthcare utilization among patients with chronic pain. This study examined the relationship between perceived pain tolerance in chronic pain patients and …

Honors Oracle, February 2022, Marshall University Honors College

Honors Oracle

Marshall University’s Honors College newsletter.

Sr 21-22-23 Ucc, Marshall University Faculty Senate

Recommendations

No abstract provided.

Sr 21-22-24 Ucc, Marshall University Faculty Senate

Recommendations

No abstract provided.

Chromosome-Level Genome Of Schistosoma Haematobium Underpins Genome-Wide Explorations Of Molecular Variation., Andreas J Stroehlein, Pasi K Korhonen, V Vern Lee, Stuart A Ralph, Margaret Mentink-Kane, Hong You, Donald P Mcmanus, Louis-Albert Tchuem Tchuenté, J Russell Stothard, Parwinder Kaur, Olga Dudchenko, Erez Lieberman Aiden, Bicheng Yang, Huanming Yang, Aidan M Emery, Bonnie L Webster, Paul J. Brindley, David Rollinson, Bill C H Chang, Robin B Gasser, Neil D Young

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is one of the most neglected tropical diseases worldwide, afflicting > 100 million people. It is characterised by granulomata, fibrosis and calcification in urogenital tissues, and can lead to increased susceptibility to HIV/AIDS and squamous cell carcinoma of the bladder. To complement available treatment programs and break the transmission of disease, sound knowledge and understanding of the biology and ecology of S. haematobium is required. Hybridisation/introgression events and molecular variation among members of the S. haematobium-group might effect important biological and/or disease traits as well as the morbidity of disease …

Amjambo Africa! (February 2022), Kathreen Harrison

Amjambo Africa!

In this Issue

Afghan Resettlement ............2/3

Lunar New Year ........................4

Maine Youth Network .............5

Afrofuturism with MHC......... 7

Editorial .....................................8

Translations French .........................9/13

Swahili .......................10/13

Somali .......................11/13

Kinyarwanda ............12/13

Portuguese ................28/30

Spanish ......................29/30

MCF grant opportunities ......14

Legislative update ...................15

Tips & Info ........................16/31

New Roots Farm .....................17

The Samosa Story .............18/19

Health&Wellness... ............20-27

Cardiac Health In English & translations

Columns ..................................32

Maine Equal Justice South Portland Sustainability MIRC

Tax Season...33

In English & translations

New Voices columns ..............34

Rupal Ramesh Shah Roseline Souebele

Hope in Augusta .................... 37

The Influence Of Social Determinants Of Health On The Provision Of Postpartum Contraceptives In Medicaid, Irene Nsiah, Nidhi Vij Mali, Marie Barnard, Swarnali Goswami

Faculty and Student Publications

Disparities continue to exist in the timely provision of postpartum contraception. This study aimed to identify prevalence and factors associated with postpartum contraception provision among women enrolled in Medicaid. A retrospective cohort study was conducted using the 2014 National Medicaid data, linked to county‐level social vulnerability index (SVI) data. Women aged 15–44 with a live birth in 2014 were included. Multivariable logistic regression was used to predict 3‐day provision of long‐acting reversible contraception (LARC) and 60‐day provision of most effective or moderately effective contraceptives (MMEC). Overall, 3‐day LARC provision was 0.2% while 60‐day MMEC was 36.3%. Significantly lower odds of …

Phytochemical Screening, In Vitro And In Silico Studies Of Volatile Compounds From Petroselinum Crispum (Mill) Leaves Grown In Saudi Arabia, Ahmed I. Foudah, Mohammad H. Alqarni, Aftab Alam, Mohammad Ayman Salkini

Faculty and Student Publications

The herbal plant Petroselinum crispum (P. crispum) (Mill) is commonly available around the world. In this study, the leaves of the herbal plant P. crispum were collected from the central region of Al-Kharj, Saudi Arabia, to explore their in vitro pharmacological activity. Essential oil from the leaves of P. crispum was isolated using the hydrodistillation method. The composition of P. crispum essential oil (PCEO) was determined using Gas chromatography-mass spectrometry (GC-MS). A total of 67 components were identified, representing approximately 96.02% of the total volatile composi-tion. Myristicin was identified as the principal constituent (41.45%). The in vitro biological activity was …

A Multitarget Approach To Evaluate The Efficacy Of Aquilaria Sinensis Flower Extract Against Metabolic Syndrome, Hee Sung Chae, Olivia Dale, Tahir Maqbool Mir, Bharathi Avula

Faculty and Student Publications

Aquilaria sinensis (Lour.) Spreng is known for its resinous secretion (agarwood), often secreted in defense against injuries. We investigated the effects of A. sinensis flower extract (AF) on peroxisome proliferator-activated receptors alpha and gamma (PPARα and PPARγ), liver X receptor (LXR), glucose uptake, and lipid accumulation (adipogenesis). Activation of PPARα, PPARγ and LXR was determined in hepatic (HepG2) cells by reporter gene assays. Glucose uptake was determined in differentiated muscle (C2C12) cells using 2-NBDG (2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose). Adipogenesis was determined in adipocytes (3T3-L1 cells) by Oil red O staining. At a concentration of 50 µg/mL, AF caused 12.2-fold activation of PPARα and …

Head And Neck Cancer Survivorship Consensus Statement From The American Head And Neck Society, Neerav Goyal, Andrew Day, Joel Epstein, Joseph Goodman, Evan Graboyes, Scharukh Jalisi, Ana P Kiess, Jamie A Ku, Matthew C Miller, Aru Panwar, Vijay A Patel, Assuntina Sacco, Vlad Sandulache, Amy M. Williams, Daniel Deschler, D. Gregory Farwell, Cherie-Ann Nathan, Carole Fakhry, Nishant Agrawal

Otolaryngology Articles

Objectives: To provide a consensus statement describing best practices and evidence regarding head and neck cancer survivorship.

Methods: Key topics regarding head and neck cancer survivorship were identified by the multidisciplinary membership of the American Head and Neck Society Survivorship, Supportive Care & Rehabilitation Service. Guidelines were generated by combining expert opinion and a review of the literature and categorized by level of evidence.

Results: Several areas regarding survivorship including dysphonia, dysphagia, fatigue, chronic pain, intimacy, the ability to return to work, financial toxicity, lymphedema, psycho-oncology, physical activity, and substance abuse were identified and discussed. Additionally, the group identified and …

Breakfast With Q-A-Mom: Understanding & Combatting The Stealth Threat Of Women Engaged With Digital Domestic Terrorist Organizations, Leah A. Plunkett

Notre Dame Journal on Emerging Technologies

This essay proceeds in three parts. It provides (1) a high-level description of what QAnon is and who the Q-A-Moms are; (2) an analysis of how and why women join QAnon, importing the general “quest for personal significance” framework (characterized by “need[s], network, and narrative”) from researchers in psychology to legal scholarship for this specific query into Q-A-Moms; and (3) an initial thought challenge to building the solution space for combatting the threat Q-A-Moms pose. This approach takes the core of the Facebook Supreme Court model (creating new quasi-judicial and law enforcement structures within the private digital sector to address …

Ranking The Biases: The Choice Of Otus Vs. Asvs In 16s Rrna Amplicon Data Analysis Has Stronger Effects On Diversity Measures Than Rarefaction And Otu Identity Threshold, Marlène Chiarello, Mark Mccauley, Sébastien Villéger, Colin R. Jackson

Faculty and Student Publications

Advances in the analysis of amplicon sequence datasets have introduced a methodological shift in how research teams investigate microbial biodiversity, away from sequence identity-based clustering (producing Operational Taxonomic Units, OTUs) to denoising methods (producing amplicon sequence variants, ASVs). While denoising methods have several inherent properties that make them desirable compared to clustering-based methods, questions remain as to the influence that these pipelines have on the ecological patterns being assessed, especially when compared to other methodological choices made when processing data (e.g. rarefaction) and computing diversity indices. We compared the respective influences of two widely used methods, namely DADA2 (a denoising …

Covid’S Counterpunch: State Legislative Assaults On Publichealth Emergency Powers, James G. Hodge Jr., Jennifer L. Piatt

Brigham Young University Journal of Public Law

Amid the most impactful health crisis in over a century, COVID’s “counterpunch” entails aggressive efforts by numerous state legislatures to diminish state and local public health emergency powers. It is an incredulous movement facially supported by a need to appropriately balance economic interests and rights with communal health objectives. At its political core, however, is a “power grab” by legislatures to free their constituents from extensive emergency powers (e.g., social distancing, assembly limits, and business closures). Never mind the fact that these interventions, when used effectively and constitutionally, save lives and reduce morbidity. Public health agents and activists are understandably …

Probability Models With Discrete And Continuous Parts, James E. Marengo, David L. Farnsworth

Articles

In mathematical statistics courses, students learn that the quadratic function E ((X – x )-squared) is minimized when x is the mean of the random variable X, and that the graphs of this function for any two distributions of X are simply translates of each other. We focus on the problem of minimizing the function defined by y ( x) = E ( IX – xI-squared ) in the context of mixtures of probability distributions of the discrete, absolutely continuous, and singular continuous types. This problem is important, for example, in Bayesian statistics, when one attempts to compute the decision …

Degradation Of The E. Coli Antitoxin Mqsa By The Proteolytic Complex Clpxp Is Regulated By Zinc Occupancy And Oxidation, Margaret R. Vos, Benjamin Piraino, Christopher J. Labreck, Negar Rahmani, Catherine E. Trebino, Marta Schoenle, Wolfgang Peti, Jodi L. Camberg, Rebecca Page

Cell and Molecular Biology Faculty Publications

It is well established that the antitoxins of toxin-antitoxin (TA) systems are selectively degraded by bacterial proteases in response to stress. However, how distinct stressors result in the selective degradation of specific antitoxins remain unanswered. MqsRA is a TA system activated by various stresses, including oxidation. Here, we reconstituted the Escherichia coli ClpXP proteolytic machinery in vitro to monitor degradation of MqsRA TA components. We show that the MqsA antitoxin is a ClpXP proteolysis substrate, and that its degradation is regulated by both zinc occupancy in MqsA and MqsR toxin binding. Using NMR chemical shift perturbation mapping, we show that …

Spartan Daily, February 1, 2022, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2022

Volume 158, Issue 2

2022 Gray Wolf Questions And Answers, United States Fish And Wildlife Service

United States Fish and Wildlife Service: Publications

2022 Gray Wolf Questions and Answers

What does the February 10, 2022, ruling mean?

How does this ruling affect wolves in the Northern Rocky Mountains?

When does the court decision to vacate the delisting rule go into effect?

What is the legal status of gray wolves as of this ruling?

Is the Service continuing its status review of wolves in the western United States?

Is emergency listing an option for the Northern Rocky Mountain population?

Are wolf hunts going to stop as a result of the court decision?

How does this ruling affect wolves in Yellowstone National Park?

Where can …

Motivations Do Not Decrease Procrastination, So What Can We Do?, Olga Kosheleva, Vladik Kreinovich, Christian Servin

Departmental Technical Reports (CS)

Students often start working on their assignments late and, as a result, turn them in late. This procrastination makes grading more difficult. It also delays posting correct solutions that could help students understand their mistakes – and this hinders the students’ progress in studying following topics. At first glance, motivation seems to be a solution to all pedagogical problems: a motivated student eagerly collaborates with the instructor to learn more. Motivation indeed increases students’ knowledge, but, unfortunately, it does not decrease procrastination. So what can we do? We can institute heavy penalties for late submissions, but this would unfairly punish …

Houtman Abrolhos Islands Fish Habitat Protection Area: A Summary Of Marine Resource Use And Ecological Attributes, Scott N. Evans, Nick Konzewitsch, Lynda M. Bellchambers

Fisheries Research Reports

The Houtman Abrolhos Islands (Abrolhos) is an archipelago of up to 210 small islands and associated reefs located approximately 65-90 km offshore from Geraldton, Western Australia (WA). The islands and waters of the Abrolhos are of significance for both land-based and marine based values. The marine state territorial waters of the Abrolhos are managed by the Department of Primary Industries and Regional Development (DPIRD) as the Houtman Abrolhos Islands Fish Habitat Protection Area (Abrolhos FHPA). This report aims to provide a summary of the DPIRD data on aquatic resource use (e.g., aquaculture, commercial, recreational and charter fishing) and ecological attributes …

Synergic Antitumor Effect Of Photodynamic Therapy And Chemotherapy Mediated By Nano Drug Delivery Systems, Mozhgan Aghajanzadeh, Mostafa Zamani, Fereshteh Rajabi Kouchi, Josh Eixenberger, Dorsa Shirini, David Estrada, Farhad Shirini

Materials Science and Engineering Faculty Publications and Presentations

This review provides a summary of recent progress in the development of different nano-platforms for the efficient synergistic effect between photodynamic therapy and chemotherapy. In particular, this review focuses on various methods in which photosensitizers and chemotherapeutic agents are co-delivered to the targeted tumor site. In many cases, the photosensitizers act as drug carriers, but this review, also covers different types of appropriate nanocarriers that aid in the delivery of photosensitizers to the tumor site. These nanocarriers include transition metal, silica and graphene-based materials, liposomes, dendrimers, polymers, metal–organic frameworks, nano emulsions, and biologically derived nanocarriers. Many studies have demonstrated various …

From Hemispheric Asymmetry Through Sensorimotor Experiences To Cognitive Outcomes In Children With Cerebral Palsy, Iryna Babik

Psychological Sciences Faculty Publications and Presentations

Recent neuroimaging studies allowed us to explore abnormal brain structures and interhemispheric connectivity in children with cerebral palsy (CP). Behavioral researchers have long reported that children with CP exhibit suboptimal performance in different cognitive domains (e.g., receptive and expressive language skills, reading, mental imagery, spatial processing, subitizing, math, and executive functions). However, there has been very limited cross-domain research involving these two areas of scientific inquiry. To stimulate such research, this perspective paper proposes some possible neurological mechanisms involved in the cognitive delays and impairments in children with CP. Additionally, the paper examines the ways motor and sensorimotor experience during …

Baseball Media Guide 2022, Wofford College. Department Of Athletics

Media Guides

No abstract provided.

Office Of Equity And Inclusion Newsletter - February 2022, Office Of Equity And Inclusion, East Tennessee State University

Office of Equity and Inclusion Newsletters

No abstract provided.

Premier: The Magazine Of The Unlv Harrah College Of Hospitality, Matt Jacob, Angela Ramsey, Caitlyn Lopez, Stowe Shoemaker, Maggie Hausbeck, Alexandra Liebman

Premier: The Magazine of the UNLV Harrah Hotel College

Of the countless hospitality programs around the world, why does the Harrah College of Hospitality consistently rank at the top? I believe the college's excellence stems from our ability to leverage our strengths with those of our partners to do great things. It's that simple.

This approach has certainly been in play as we've navigated the difficulties of the past two years. We've worked with our friends in industry and academia to bolster our internship and mentorship programs, research, and interdisciplinary projects, all with the intent of expanding the knowledge base of the hospitality discipline and building a pipeline of …

Kentucky Warbler (Vol. 98, No. 1), Kentucky Library Research Collections

The Kentucky Warbler

No abstract provided.