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2022

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Daily Eastern News: February 02, 2022, Eastern Illinois University Feb 2022

Daily Eastern News: February 02, 2022, Eastern Illinois University

February

No abstract provided.

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Optimization Of Silicon Nitride Waveguide Platform For On-Chip Virus Detection, Raghi S. El El Shamy, Mohamed A. Swillam, Xun Li Feb 2022

Optimization Of Silicon Nitride Waveguide Platform For On-Chip Virus Detection, Raghi S. El El Shamy, Mohamed A. Swillam, Xun Li

Faculty Journal Articles

This work presents a rigorous and generic sensitivity analysis of silicon nitride on silicon dioxide strip waveguide for virus detection. In general, by functionalizing the waveguide surface with a specific antibodies layer, we make the optical sensor sensitive only to a particular virus. Unlike conventional virus detection methods such as polymerase chain reaction (PCR), integrated refractive index (RI) optical sensors offer cheap and mass-scale fabrication of compact devices for fast and straightforward detection with high sensitivity and selectivity. Our numerical analysis includes a wide range of wavelengths from visible to mid-infrared. We determined the strip waveguide’s single-mode dimensions and the …

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The Natural Isoflavone Biochanin-A Synergizes 5-Fluorouracil Anticancer Activity In Vitro And In Vivo In Ehrlich Solid-Phase Carcinoma Model, Mohamed Mahmoud, Maha R.A. Abdollah, Mohamed E. Elsesy, Dalal A. Abou El Ella, Suher K. Zada, Mai Fathy Tolba Feb 2022

The Natural Isoflavone Biochanin-A Synergizes 5-Fluorouracil Anticancer Activity In Vitro And In Vivo In Ehrlich Solid-Phase Carcinoma Model, Mohamed Mahmoud, Maha R.A. Abdollah, Mohamed E. Elsesy, Dalal A. Abou El Ella, Suher K. Zada, Mai Fathy Tolba

Pharmacy

Isoflavones are considered one of the most extensively studied plant-derived phytoestrogenic compounds. Of these, Biochanin A (Bio-A), a natural isoflavone abundant in cabbage, alfalfa, and red clover, has drawn a lot of attention. As reported in multiple studies, Bio-A possesses a promising anticancer activity against estrogen receptor–positive (ER+)  breast cancer. The current study investigated the working hypothesis that Bio-A could synergistically enhance the potency of 5-fluorouracil (5-FU) in ER+ breast cancer. The hypothesis was tested both in vitro on hormone receptor–positive (MCF-7) and triple-negative breast cancer cells (MDA-MB231). Additionally, in vivo studies were performed in the Ehrlich solid-phase carcinoma mouse …

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Clumping Morphology Influences Virulence Uncoupled From Echinocandin Resistance In Candida Glabrata, Chenlin Hu, Gary Fong, Sebastian Wurster, Dimitrios P. Kontoyiannis, Nicholas D. Beyda Feb 2022

Clumping Morphology Influences Virulence Uncoupled From Echinocandin Resistance In Candida Glabrata, Chenlin Hu, Gary Fong, Sebastian Wurster, Dimitrios P. Kontoyiannis, Nicholas D. Beyda

Pharmacy Faculty Articles and Research

Here, we report two paired sets of an index wild-type Candida glabrata bloodstream isolate and subsequent echinocandin-resistant FKS mutant. One paired set exhibited a higher proportion of clumping cells and was more virulent in the invertebrate host Galleria mellonella than the other paired set. No virulence difference between the paired index and FKS strains was observed. These findings imply a potential link of clumping morphology with virulence in C. glabrata that is uncoupled from FKS-mediated echinocandin resistance. IMPORTANCE Candida glabrata is a leading cause of invasive candidiasis. In contrast to other species, it has a high propensity for developing resistance …

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Effects Of Metformin Combined With Antifolates On Hepg2 Cell Metabolism And Cellular Proliferation, Sherouk M. Tawfik, Maha R.A. Abdollah, M. M. Elmazar, Hassan A. N. El-Fawal, Anwar Abdelnaser Feb 2022

Effects Of Metformin Combined With Antifolates On Hepg2 Cell Metabolism And Cellular Proliferation, Sherouk M. Tawfik, Maha R.A. Abdollah, M. M. Elmazar, Hassan A. N. El-Fawal, Anwar Abdelnaser

Pharmacy

Hepatocellular carcinoma (HCC), one of the most prevalent types of cancers worldwide, continues to maintain high levels of resistance to standard therapy. As clinical data revealed poor response rates, the need for developing new methods has increased to improve the overall wellbeing of patients with HCC. Furthermore, a growing body of evidence shows that cancer metabolic changes are a key feature of many types of human malignancies. Metabolic reprogramming refers to cancer cells’ ability to change their metabolism in order to meet the increased energy demand caused by continuous growth, rapid proliferation, and other neoplastic cell characteristics. For these reasons, …

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Novel Approaches To Coronary Perforations: Everything But The Kitchen Sink., Dany Jacob, Michael P Savage, David L Fischman Feb 2022

Novel Approaches To Coronary Perforations: Everything But The Kitchen Sink., Dany Jacob, Michael P Savage, David L Fischman

Division of Cardiology Faculty Papers

No abstract provided.

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A Precise Dispenser Design For Canine Cognition Research, Walker Arce, Jeffrey R. Stevens Feb 2022

A Precise Dispenser Design For Canine Cognition Research, Walker Arce, Jeffrey R. Stevens

Department of Electrical and Computer Engineering: Faculty Publications

Some forms of canine cognition research require a dispenser that can accurately dispense precise quantities of treats. When using off-the-shelf or retrofitted dispensers, there is no guarantee that a precise number of treats will be dispensed. Often, they will over-dispense treats, which may not be acceptable for some tasks. Here we describe a 3D-printed precise treat dispenser with a 59-treat capacity driven by a stepper motor drive and controlled by an integrated Raspberry Pi. The dispenser can be built for less than 200 USD and is fully 3D printable. While off-the-shelf dispensers can result in an error rate of 20–30%, …

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An Efficient Method Of Evaluating Multiple Concurrent Management Actions On Invasive Populations, Amy J. Davis, Randy Farrar, Brad Jump, Parker Hall, Travis Guerrant, Kim M. Pepin Feb 2022

An Efficient Method Of Evaluating Multiple Concurrent Management Actions On Invasive Populations, Amy J. Davis, Randy Farrar, Brad Jump, Parker Hall, Travis Guerrant, Kim M. Pepin

United States Department of Agriculture Wildlife Services: Staff Publications

Evaluating the efficacy of management actions to control invasive species is crucial for maintaining funding and to provide feedback for the continual improvement of management efforts. However, it is often difficult to assess the efficacy of control methods due to limited resources for monitoring. Managers may view effort on monitoring as effort taken away from performing management actions. We developed a method to estimate invasive species abundance, evaluate management effectiveness, and evaluate population growth over time from a combination of removal activities (e.g., trapping, ground shooting) using only data collected during removal efforts (method of removal, date, location, number of …

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Filling The Gap: Molting Behavior Of Colima Warblers And Research Opportunities For Understudied North American Songbirds, Benjamin Gochanour, Jose L. Alcantara, Paula Cimprich, Jeffrey F. Kelly, Andrea Contina Feb 2022

Filling The Gap: Molting Behavior Of Colima Warblers And Research Opportunities For Understudied North American Songbirds, Benjamin Gochanour, Jose L. Alcantara, Paula Cimprich, Jeffrey F. Kelly, Andrea Contina

School of Integrative Biological & Chemical Sciences Faculty Publications

We implemented stable isotope analysis to evaluate the molt behavior of the Colima warbler (Leiothlypis crissalis), an understudied migratory songbird occurring in Mexico and recently discovered breeding in the southern part of Texas, USA. We built a geostatistical model showing variation in deuterium precipitation values (d2Hp) across a latitudinal gradient within the Colima warbler breeding range in northeastern Mexico. Then, based on stable isotope ratios of deuterium in feathers (d2Hf), we assigned wintering Colima warblers captured in Central Mexico to possible molting areas near the southwestern portion of the species' breeding range. To the best of our knowledge, this is …

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Hyperspectral Imaging With Machine Learning To Differentiate Cultivars, Growth Stages, Flowers, And Leaves Of Industrial Hemp (Cannabis Sativa L.), Yuzhen Lu, Sierra N. Young, Eric Linder, Brian Whipker, David Suchoff Feb 2022

Hyperspectral Imaging With Machine Learning To Differentiate Cultivars, Growth Stages, Flowers, And Leaves Of Industrial Hemp (Cannabis Sativa L.), Yuzhen Lu, Sierra N. Young, Eric Linder, Brian Whipker, David Suchoff

Civil and Environmental Engineering Faculty Publications

As an emerging cash crop, industrial hemp (Cannabis sativa L.) grown for cannabidiol (CBD) has spurred a surge of interest in the United States. Cultivar selection and harvest timing are important to produce CBD hemp profitably and avoid economic loss resulting from the tetrahydrocannabinol (THC) concentration in the crop exceeding regulatory limits. Hence there is a need for differentiating CBD hemp cultivars and growth stages to aid in cultivar and genotype selection and optimization of harvest timing. Current methods that rely on visual assessment of plant phenotypes and chemical procedures are limited because of its subjective and destructive nature. In …

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Constitutive Activation Of Canonical Wnt Signaling Disrupts Choroid Plexus Epithelial Fate, Arpan Parichha, Varun Suresh, Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben-Reuven, Tsviya Olender, M Mark Taketo, Velena Radosevic, Mihaela Bobic-Rasonja, Sara Trnski, Michael J Holtzman, Nataša Jovanov-Milosevic, Orly Reiner, Shubha Tole Feb 2022

Constitutive Activation Of Canonical Wnt Signaling Disrupts Choroid Plexus Epithelial Fate, Arpan Parichha, Varun Suresh, Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben-Reuven, Tsviya Olender, M Mark Taketo, Velena Radosevic, Mihaela Bobic-Rasonja, Sara Trnski, Michael J Holtzman, Nataša Jovanov-Milosevic, Orly Reiner, Shubha Tole

Open Access Publications

The choroid plexus secretes cerebrospinal fluid and is critical for the development and function of the brain. In the telencephalon, the choroid plexus epithelium arises from the Wnt- expressing cortical hem. Canonical Wnt signaling pathway molecules such as nuclear β-CATENIN are expressed in the mouse and human embryonic choroid plexus epithelium indicating that this pathway is active. Point mutations in human β-CATENIN are known to result in the constitutive activation of canonical Wnt signaling. In a mouse model that recapitulates this perturbation, we report a loss of choroid plexus epithelial identity and an apparent transformation of this tissue to a …

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“I Love A Party With A Happy Atmosphere”; Notes On The Ontology Of Interpersonal Atmosphere, H Drayson Feb 2022

“I Love A Party With A Happy Atmosphere”; Notes On The Ontology Of Interpersonal Atmosphere, H Drayson

School of Art, Design and Architecture

No abstract provided.

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Similar Mortality Among United States Veterans With Invasive And Noninvasive Pneumonia Due To Group B Streptococcus, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, Federico Perez Feb 2022

Similar Mortality Among United States Veterans With Invasive And Noninvasive Pneumonia Due To Group B Streptococcus, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, Federico Perez

Faculty Scholarship

Background: The nosology of noninvasive pneumonia due to group B Streptococcus (GBS) is not well defined. This study compared clinical characteristics and outcomes of patients with invasive pneumonia and noninvasive pneumonia caused by GBS. Methods: We conducted a retrospective cohort study among Veterans Affairs (VA) healthcare users between 2008 and 2017. Using data from electronic health records, we identified patients who had blood or respiratory cultures that grew GBS and had invasive pneumonia or noninvasive pneumonia. We analyzed patient and infection characteristics associated with all-cause mortality, including among the subset of patients with cultures that were monomicrobial for GBS. Results: …

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The Natural Isoflavone Biochanin‐A Synergizes 5‐Fluorouracil Anticancer Activity In Vitro And In Vivo In Ehrlich Solid‐Phase Carcinoma Model, Suher K. Zada, Mohamed Mahmoud, Maha R. A. Abdollah, Mohamed E. Elsesy Feb 2022

The Natural Isoflavone Biochanin‐A Synergizes 5‐Fluorouracil Anticancer Activity In Vitro And In Vivo In Ehrlich Solid‐Phase Carcinoma Model, Suher K. Zada, Mohamed Mahmoud, Maha R. A. Abdollah, Mohamed E. Elsesy

Faculty Journal Articles

Isoflavones are considered one of the most extensively studied plant-derived phytoestrogenic compounds. Of these, Biochanin A (Bio-A), a natural isoflavone abundant in cabbage, alfalfa, and red clover, has drawn a lot of attention. As reported in multiple studies, Bio-A possesses a promising anticancer activity against estrogen receptor-positive (ER+) breast cancer. The current study investigated the working hypothesis that Bio-A could synergistically enhance the potency of 5-fluorouracil (5-FU) in ER+ breast cancer. The hypothesis was tested both in vitro on hormone receptor-positive (MCF-7) and triple-negative breast cancer cells (MDA-MB231). Additionally, in vivo studies were performed in the Ehrlich solid-phase carcinoma mouse …

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Comparison Of Human Urinary Exosomes Isolated Via Ultracentrifugation Alone Versus Ultracentrifugation Followed By Sec Column-Purification, Kun Huang, Sudha Garimella, Alyssa Clay-Gilmour, Lucia Vojtech, Bridget Armstrong, Madison Bessonny, Alexis Stamatikos Feb 2022

Comparison Of Human Urinary Exosomes Isolated Via Ultracentrifugation Alone Versus Ultracentrifugation Followed By Sec Column-Purification, Kun Huang, Sudha Garimella, Alyssa Clay-Gilmour, Lucia Vojtech, Bridget Armstrong, Madison Bessonny, Alexis Stamatikos

Faculty Publications

Chronic kidney disease is a progressive, incurable condition that involves a gradual loss of kidney function. While there are no non-invasive biomarkers available to determine whether individuals are susceptible to developing chronic kidney disease, small RNAs within urinary exosomes have recently emerged as a potential candidate to use for assessing renal function. Ultracentrifugation is the gold standard for urinary exosome isolation. However, extravesicular small RNA contamination can occur when isolating exosomes from biological fluids using ultracentrifugation, which may lead to misidentifying the presence of certain small RNA species in human urinary exosomes. Therefore, we characterized human urinary exosomal preparations isolated …

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Therapeutic Use Of Serious Games In Mental Health: Scoping Review, Alice Dewhirst, Richard Laugharne, Rohit Shankar Feb 2022

Therapeutic Use Of Serious Games In Mental Health: Scoping Review, Alice Dewhirst, Richard Laugharne, Rohit Shankar

Peninsula Medical School

Background There has been an increase in the development and application of serious games to support management of mental ill health, but their full impact is unclear. Aims Evaluation of the current evidence of acceptability and effectiveness of serious games in improving mental health disorders. Method A PRISMA-guided scoping review was conducted, using a predefined criteria and a relevant word combination on three databases: EMBASE, Medline and PsycINFO. Each included study was examined for game format, study type, number of participants, basic demographics, disorder targeted, recruitment, setting, control conditions, duration and follow-up, study attrition, primary outcomes and their results. Each …

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Single Circulating-Tumor-Cell-Targeted Sequencing To Identify Somatic Variants In Liquid Biopsies In Non-Small-Cell Lung Cancer Patients, Mouadh Barbirou, Amanda Miller, Yariswamy Manjunath, Arturo B Ramirez, Nolan G Ericson, Kevin F Staveley-O'Carroll, Jonathan B Mitchem, Wesley C Warren, Aadel A Chaudhuri, Yi Huang, Guangfu Li, Peter J Tonellato, Jussuf T Kaifi Feb 2022

Single Circulating-Tumor-Cell-Targeted Sequencing To Identify Somatic Variants In Liquid Biopsies In Non-Small-Cell Lung Cancer Patients, Mouadh Barbirou, Amanda Miller, Yariswamy Manjunath, Arturo B Ramirez, Nolan G Ericson, Kevin F Staveley-O'Carroll, Jonathan B Mitchem, Wesley C Warren, Aadel A Chaudhuri, Yi Huang, Guangfu Li, Peter J Tonellato, Jussuf T Kaifi

2020-Current year OA Pubs

Non-small-cell lung cancer (NSCLC) accounts for most cancer-related deaths worldwide. Liquid biopsy by a blood draw to detect circulating tumor cells (CTCs) is a tool for molecular profiling of cancer using single-cell and next-generation sequencing (NGS) technologies. The aim of the study was to identify somatic variants in single CTCs isolated from NSCLC patients by targeted NGS. Thirty-one subjects (20 NSCLC patients, 11 smokers without cancer) were enrolled for blood draws (7.5 mL). CTCs were identified by immunofluorescence, individually retrieved, and DNA-extracted. Targeted NGS was performed to detect somatic variants (single-nucleotide variants (SNVs) and insertions/deletions (Indels)) across 65 oncogenes and …

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Liquid-Liquid Phase Separation Of Tdp-43 And Fus In Physiology And Pathology Of Neurodegenerative Diseases, Jenny L Carey, Lin Guo Feb 2022

Liquid-Liquid Phase Separation Of Tdp-43 And Fus In Physiology And Pathology Of Neurodegenerative Diseases, Jenny L Carey, Lin Guo

Department of Biochemistry and Molecular Biology Faculty Papers

Liquid-liquid phase separation of RNA-binding proteins mediates the formation of numerous membraneless organelles with essential cellular function. However, aberrant phase transition of these proteins leads to the formation of insoluble protein aggregates, which are pathological hallmarks of neurodegenerative diseases including ALS and FTD. TDP-43 and FUS are two such RNA-binding proteins that mislocalize and aggregate in patients of ALS and FTD. They have similar domain structures that provide multivalent interactions driving their phase separation in vitro and in the cellular environment. In this article, we review the factors that mediate and regulate phase separation of TDP-43 and FUS. We also …

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The Optimum Grazing Time Based On Milk Fatty Acids And Yield For Holstein Lactating Cows Through Eco-Pastoral System In Alpine Grassland, M. Kim, J. Y. Kim, M. H. Jo, C. H. Kim, K. Sung Feb 2022

The Optimum Grazing Time Based On Milk Fatty Acids And Yield For Holstein Lactating Cows Through Eco-Pastoral System In Alpine Grassland, M. Kim, J. Y. Kim, M. H. Jo, C. H. Kim, K. Sung

IGC Proceedings (1977-2023)

This study aimed to detect the optimum grazing time based on milk fatty acids and yield for the Holstein cow (Bos taurus) through eco-pastoral system in Korean alpine grassland. The treatment of grazing time was 3 levels: Non-grazing, Half-day grazing, Full-day grazing. First, the difference of milk fatty acids (saturated fatty acid, unsaturated fatty acid, Total ω-3, etc.) and milk yield was checked by grazing time via ANOVA. Second, various measurements of milk fatty acids were reduced to principal components for effective and obvious detecting the variation as a grazing time. Final, the variations of milk fatty acid …

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Prospects Of Cattle Farming In An Era Of Land Degradation-Perceptions Of The Farmers In The Okakarara Communal Area, Namibia, H. T. N. Heita, D. Gunner Feb 2022

Prospects Of Cattle Farming In An Era Of Land Degradation-Perceptions Of The Farmers In The Okakarara Communal Area, Namibia, H. T. N. Heita, D. Gunner

IGC Proceedings (1977-2023)

Livestock farming plays an important role in many rural people s’ livelihoods around the globe. The sector is, however, faced with numerous challenges, particularly land degradation. Namibia, one of the driest countries in the world, is no exception to land degradation challenges, mostly among communal rangeland areas. Several studies and interventions on land degradation have been conducted in the country, however, with limited or no information on farmers' perceptions. Although land degradation may be a physical process, understanding its causes, process, indicators, and effects from the own users’ is indispensable. Here, we assessed farmers' perception in the eastern part of …

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Effects Of Seasonal Rest Grazing And Diet Selection Of Sheep On Pasture Composition In Bromus Inermis Improved Meadow Steppe, H. Zhang, Y. J. Zhang, N. Liu Feb 2022

Effects Of Seasonal Rest Grazing And Diet Selection Of Sheep On Pasture Composition In Bromus Inermis Improved Meadow Steppe, H. Zhang, Y. J. Zhang, N. Liu

IGC Proceedings (1977-2023)

To develop sustainable grazing management systems based on highly-productive dominant species, it is critical to maintain pasture growth and prevent land degradation on meadow steppe. A field study was performed to identify the impact of seasonal rest grazing on diet selection of sheep and pasture composition in Bromus inermis improved meadow steppe from 2015 to 2017 in Hulunbuir, Inner Mongolia, China. Three seasonal rest grazing strategies were conducted: R1 included a spring rest from June 15 to July 15, R2 a summer rest from July 15 to August 15 and R3 an autumn rest from August 15 to September 15. …

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The Effect Of Hay Supplementation On Performance Of Grazing Alpaca In The Peruvian Andes, M. Enciso, C. Gómez, C. Osorio Feb 2022

The Effect Of Hay Supplementation On Performance Of Grazing Alpaca In The Peruvian Andes, M. Enciso, C. Gómez, C. Osorio

IGC Proceedings (1977-2023)

Productivity of alpaca grazing rangelands in the Andes is often limited by the low availability and quality of those pastures during the dry season of the year. The use as supplements of forages cultivated during the rainy season in appropriate areas in the Andes may be a strategy to improve performance of alpacas. Therefore, the supplementation of oat-vetch pellets or oat hay was evaluated and compared with a control group without supplementation. Sixty three female alpacas (15 months of age, 34 ± 1.0 kg BW), divided in three groups, grazing range pastures (6.1% crude protein and 61.3% NDF) during dry …

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Status Inconsistent Entrepreneurs And Robert Merton's Innovation, Paul E. Krueger Feb 2022

Status Inconsistent Entrepreneurs And Robert Merton's Innovation, Paul E. Krueger

Great Plains Sociologist

From where springs forth entrepreneurs? The United States is experiencing an unprecedented increase of entrepreneurs. They have emerged in growing numbers during the past ten to fifteen years (Drucker, 1985), reaching a crescendo in what American Demographics has called the "Entrepreneurial Eighties" (Russell, 1985). Los Angeles Mayor Tom Bradley recently recognized this occurrence by declaring an "Entrepreneur Day" for his city at the annual meeting of the Young Entrepreneurs Organization (Givens and Goldberg, 1986). What is an entrepreneur? There have been many definitions since the term was coined by French economist J. B. Say in about 1800 (Drucker, 1985). According …

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Student Motivation, Anxiety And Pass/Fail Grading: A Sotl Project, Patrick R. Walden Feb 2022

Student Motivation, Anxiety And Pass/Fail Grading: A Sotl Project, Patrick R. Walden

Teaching and Learning in Communication Sciences & Disorders

This SoTL project explored sources of student anxiety and motivation across student assessment conditions of traditional numerical grading and pass/fail grading and sought to determine if pass/fail grading was helpful in lowering student anxiety while increasing student motivation to learn. Results indicated that students scored equally well on a test of student learning across pass/fail and numerical grading groups, indicating that pass/fail grading did not lead to poorer course objective mastery. Students were similar in terms of sources of anxiety and levels of anxiety. Motivation across groups was also similar, largely extrinsic in nature, and consistent pre- to post-course. Results …

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A Critical Reflection On Adaptation Of Teaching Practices, Patricia Gibbons, Ramonda Horton, Valerie E. Johnson Feb 2022

A Critical Reflection On Adaptation Of Teaching Practices, Patricia Gibbons, Ramonda Horton, Valerie E. Johnson

Teaching and Learning in Communication Sciences & Disorders

The purpose of this paper is to provide a description of how critical reflection can be used to update and revise teaching practices in response to evolving student needs and challenges in higher education. The authors identify the types of challenges that faculty and graduate students face in the current educational environment. Generational differences between faculty and students, the impact of increased student stress levels, and advances in technology will continue to shape how we instruct graduate students. We identified a number of evidence-based practices which were reported to be useful in reducing stress and anxiety in students while still …

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Multiyear Defoliations In Southern New England Increases Oak Mortality, Jeffrey S. Ward, Chad C. Jones, Joseph P. Barsky Feb 2022

Multiyear Defoliations In Southern New England Increases Oak Mortality, Jeffrey S. Ward, Chad C. Jones, Joseph P. Barsky

Botany Faculty Publications

After decades of multiyear defoliation episodes in southern New England, Lymantria dispar dispar (LDD; previously gypsy moth) populations collapsed with the appearance of the LDD fungus in 1989. Multiyear defoliations did not occur again until 2015-2018. To assess the impact of the return of multiyear defoliations, we examined 3095 oaks on 29 permanent study areas in Connecticut and Rhode Island that were established at least eleven years before the latest outbreaks. Pre-defoliation stand level oak mortality averaged 2% (three-year basis). Post-defoliation mortality did not differ between managed and unmanaged stands, but was much higher in severely defoliated stands (36%) than …

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Algorithms For Diagnosing Heart Dysfunction In Patients With Covid-19, Feruza Kh. Inoyatova, Ulugbek K. Kayumov, Mukhlisa R. Khidoyatova Feb 2022

Algorithms For Diagnosing Heart Dysfunction In Patients With Covid-19, Feruza Kh. Inoyatova, Ulugbek K. Kayumov, Mukhlisa R. Khidoyatova

Central Asian Journal of Medicine

Purpose of the study: development and implementation into practice of optimal rehabilitation schemes for COVID-19, aimed at shortening the hospital period by effectively treating CVD and preventing complications. Materials and methods. According to these algorithms, patients were examined with a confirmed diagnosis of COVID-19 with pneumonia, hospitalized in the intensive care unit of the Zangiota №2 specialized clinic for the treatment of patients with coronavirus infection. The echocardiography study was conducted in 54 patients diagnosed with COVID-19 who were admitted to intensive care units consecutively, 2 patients were excluded from the study due to poor visualization of the heart during …

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Clinical Experience Of Triple-Negative Breast Cancer Treatment, Djakhongir R. Sabirov, Petr Y. Ignatov, Oybarchin J. Yusupova Feb 2022

Clinical Experience Of Triple-Negative Breast Cancer Treatment, Djakhongir R. Sabirov, Petr Y. Ignatov, Oybarchin J. Yusupova

Central Asian Journal of Medicine

The authors have demonstrated a successful case of treating a patient by using an optimized approach to immunological correction in the course of oncolytic therapy. Treatment began with the correction of the immune system using nonspecific immunomodulatory agents and methods. Afterwards, a course of oncolytic therapy (chemotherapy) was carried out, and at first full doses of cytostatic drugs were used, and then their dosages were lowered. At the end of the course of chemotherapy, it is recommended to use drugs that suppress the processes of proliferative reactivation of tumor cells. The authors believe that the description of this clinical experience …

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Clinical Significance Of The Density Of Tumor Microvessels In Breast Cancer In Men, Lola T. Alimkhodjaeva, Munira H. Norbekova Feb 2022

Clinical Significance Of The Density Of Tumor Microvessels In Breast Cancer In Men, Lola T. Alimkhodjaeva, Munira H. Norbekova

Central Asian Journal of Medicine

Breast cancer in men is a rare disease that accounts for less than 1% of all breast tumors. Currently, there is a need for research and search for new biomarkers for early diagnosis, monitoring of the course and prognosis of the disease, and in this aspect, the assessment of angiogenesis is of great importance. Taking into account the fact that the heterogeneity of tumor microvessels in breast cancer has not been practically studied, correlations of different types of vessels with clinical, morphological and molecular biological factors of disease prognosis, as well as with the severity of inflammatory infiltration of the …

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Morphological And Morphometric Characteristics Of Gialin Membranal Disease In Baby Birth, Rajabboy I. Israilov, Ozoda A. Mirzabekova, Abduburxon K. Kurbanov Feb 2022

Morphological And Morphometric Characteristics Of Gialin Membranal Disease In Baby Birth, Rajabboy I. Israilov, Ozoda A. Mirzabekova, Abduburxon K. Kurbanov

Central Asian Journal of Medicine

In this scientific study, morphological and morphometric indicators of hyaline membrane disease in premature infants were studied. The material was obtained from the results of clinical-anamnestic analysis of preterm infants at 22-37 weeks and lung tissue. The results show that the immaturity of lung tissue, circulatory disorders and damage to the alveolar and bronchial epithelium play an important role in the development of hyaline membrane disease in the lungs of premature infants. The results of morphometric studies showed that only 1/3 of the lungs of infants born at 22-27 weeks had air in the alveoli, the thickness of the alveolar …

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