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February 22, 2022, University Of Mississippi. Faculty Senate

Meeting Minutes

Minutes for the February 22, 2022 meeting of the University of Mississippi Faculty Senate.

Bacterial Indole As A Multifunctional Regulator Of Klebsiella Oxytoca Complex Enterotoxicity, Nagender Ledala, Mishika Malik, Karim Rezaul, Sara Paveglio, Anthony Provatas, Aaron Kiel, Melissa Caimano, Yanjiao Zhou, Jonathan Lindgren, Kristyna Krasulova, Peter Illes, Zdenek Dvorak, Sandhya Kortagere, Sabine Kienesberger, Amar Cosic, Lisa Pöltl, Ellen L. Zechner, Subho Ghosh, Sridhar Mani, Justin D. Radolf, Adam P. Matson

Faculty Research 2022

Gastrointestinal microbes respond to biochemical metabolites that coordinate their behaviors. Here, we demonstrate that bacterial indole functions as a multifactorial mitigator of Klebsiella grimontii and Klebsiella oxytoca pathogenicity. These closely related microbes produce the enterotoxins tilimycin and tilivalline; cytotoxin-producing strains are the causative agent of antibiotic-associated hemorrhagic colitis and have been associated with necrotizing enterocolitis of premature infants. We demonstrate that carbohydrates induce cytotoxin synthesis while concurrently repressing indole biosynthesis. Conversely, indole represses cytotoxin production. In both cases, the alterations stemmed from differential transcription of npsA and npsB, key genes involved in tilimycin biosynthesis. Indole also enhances conversion of tilimycin …

Ua12/2/1 Housing Guide, Wku Student Affairs

WKU Administration Documents

Magazine edition of the College Heights Herald.

• Crawford, Ashlyn. Dear Readers
• Honeck, Adelle. Houseplant Tales
• Honeck, Adelle. How Well Do You Know Your Roommate?
• Jones, Tea. The B Word: 3 Tips to Budget Finances
• Jones, Tea. Get Your Space Together
• Wilson, Gabby. The Perfect at Home Game Night
• Wilkerson, Abigail. Adventures in Dorm Living

Paradigm Versus Paradox On The Prairie: Testing Competing Stream Fish Movement Frameworks Using An Imperiled Great Plains Minnow, Zachary D. Steffensmeier, Maeghen Wedgeworth, Lauren Yancy, Noah Santee, Shannon K. Brewer, Joshuah S. Perkin

United States Geological Survey: Staff Publications

Background: Movement information can improve conservation of imperiled species, yet movement is not quantified for many organisms in need of conservation. Prairie chub (Macrhybopsis australis) is a regionally endemic freshwater fish with unquantified movement ecology and currently considered for listing under the Endangered Species Act. The purpose of this study was to test competing ecological theories for prairie chub movement, including the colonization cycle hypothesis (CCH) that posits adults must make upstream movements to compensate for downstream drift at early life stages, and the restricted movement paradigm (RMP) that describes populations as heterogeneous mixes of mostly stationary …

Facial Recognition Technology And Privacy: Race And Gender - How To Ensure The Right To Privacy Is Protected, Lindsey Jacques

San Diego International Law Journal

This Article specifically focuses on the use of FRT by the five permanent members of the United Nations (“UN”) Security Council which are China, France, the Russian Federation, the United Kingdom, and the United States (the five nations). As permanent members of the Security Council, these five nations are tasked with maintaining international security under the UN Charter.

National leaders in these countries are forced to face the question of whether the national security mitigating benefits of FRT outweigh the privacy and equity concerns the technology imposes for populations often considered the most vulnerable. This Article proposes solutions to this …

Investigation Of A Cluster Of Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infections In A Hospital Administration Building, Lucas D. Jones, Ernest R. Chan, Sarah N. Redmond, Jeffrey D. Kovach, Marlin Linger, Peter A. Zimmerman, Curtis J. Donskey

Faculty Scholarship

Objective: To investigate a cluster of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in employees working on 1 floor of a hospital administration building. Methods: Contact tracing was performed to identify potential exposures and all employees were tested for SARS-CoV-2. Whole-genome sequencing was performed to determine the relatedness of SARS-CoV-2 samples from infected personnel and from control cases in the health-care system with coronavirus disease 2019 (COVID-19) during the same period. Carbon dioxide levels were measured during a workday to assess adequacy of ventilation; readings >800 parts per million (ppm) were considered an indication of suboptimal ventilation. To assess …

Alumnus, Dr. Kevin Prime, Promotes Overall Wellness At Chiropractic Clinic In Lyman, S.C., Office Of University Communications

Gardner-Webb NewsCenter Archive

As a member of the Track and Field team at Gardner-Webb University, Kevin Prime, a native of Trinidad and Tobago, set school records in 2003 for the 60 m dash and in 2005 for the 55 m. Today, Dr. Kevin Prime is again breaking ground in the community of Lyman, S.C., as the owner of Elite Wellness Center, a chiropractic practice that also employs a medical doctor and nurse practitioner.

Meet Kylee Morris, Of Newport, N.C., Third Tucker Scholar At Gardner-Webb, Office Of University Communications

Gardner-Webb NewsCenter Archive

In the Gospel of Mark 12:29-31, Jesus gives the two most important commandments: “Love the Lord Your God with all your heart, soul, mind and strength; and love your neighbor as yourself.” These verses form the foundation for Gardner-Webb University’s most prestigious award, the Tucker Heart, Soul, Mind and Strength Scholarship. This year’s winner, Kylee Morris of Newport, N.C., embodies all of these qualities in her interactions on the basketball court, at school and in the community.

Student Who Embodies ‘Sacrifice’ And ‘Leadership’ Named Third Tucker Scholar At Gardner-Webb University, Office Of University Communications

Gardner-Webb NewsCenter Archive

A high school senior from Newport, N.C., known for her heart of service, has been named the third Tucker Scholar at Gardner-Webb University. Established in 2019 by Carolyn and Robert Tucker, longtime University benefactors, The Tucker Heart, Soul, Mind and Strength Scholarship is GWU’s most prestigious. This year’s winner, Kylee Morris, is a student-athlete at West Carteret High School, who gave up her own athletic goals to help those of her younger basketball teammates come true.

Ghost Mitochondria Drive Metastasis Through Adaptive Gcn2/Akt Therapeutic Vulnerability, Jagadish C Ghosh, Michela Perego, Ekta Agarwal, Irene Bertolini, Yuan Wang, Aaron R Goldman, Hsin-Yao Tang, Andrew V Kossenkov, Catherine J Libby, Lucia R Languino, Edward F Plow, Annamaria Morotti, Luisa Ottobrini, Marco Locatelli, David W Speicher, M Cecilia Caino, Joel Cassel, Joseph M Salvino, Marie E Robert, Valentina Vaira, Dario C Altieri

Department of Cancer Biology Faculty Papers

Cancer metabolism, including in mitochondria, is a disease hallmark and therapeutic target, but its regulation is poorly understood. Here, we show that many human tumors have heterogeneous and often reduced levels of Mic60, or Mitofilin, an essential scaffold of mitochondrial structure. Despite a catastrophic collapse of mitochondrial integrity, loss of bioenergetics, and oxidative damage, tumors with Mic60 depletion slow down cell proliferation, evade cell death, and activate a nuclear gene expression program of innate immunity and cytokine/chemokine signaling. In turn, this induces epithelial-mesenchymal transition (EMT), activates tumor cell movements through exaggerated mitochondrial dynamics, and promotes metastatic dissemination in vivo. In …

Priests Of A Fallen Creation: The Temple, Natural Theology, And Ecology In Dialogue, Eric Long

Speakers & Events

As we try to make sense of both creation’s goodness and decay, Dr. Long proposes that a fruitful path forward involves synthesizing recent advances in the three fields: natural sciences (with an emphasis on ecology), natural theology (with an emphasis on Christian natural theology), and Biblical theology (with an emphasis on reading creation as God’s earthly temple). In the lecture, Dr. Long will first develop this three-pronged, interdisciplinary approach. Then, he will demonstrate how this approach may prove fruitful in addressing five, roughly chronological, questions ranging from creation to eschatology:

• Why does creation exist?
• How can we interpret the “goodness” …

Crime And Punishment: An Empirical Study Of The Effects Of Racial Bias On Capital Sentencing Decisions, Matthew A. Gasperetti

University of Miami Law Review

Racism has left an indelible stain on American history and remains a powerful social force that continues to shape crime and punishment in the contemporary United States. In this article, I discuss the socio-legal construction of race, explore how racism infected American culture, and trace the racist history of capital punishment from the Colonial Era to the present. After framing the death penalty in cultural and historical context, I report original empirical results from one of the largest studies (n = 3,284) of mock juror capital sentencing decisions published to date. My results show that mock jurors who self reported …

“Incorrigibility Is Inconsistent With Youth”: The Supreme Court’S Missed Opportunity To Cure The Contradiction Implicit In Discretionary Jlwop Sentencing, Ana Ionescu

University of Miami Law Review

The juvenile life without parole (“JLWOP”) caselaw is based in part on the science underlying adolescent brain development. Numerous research studies have examined the behaviors and brain processes of adolescents. Courts have relied on these findings in reaching some of its most important decisions affecting juveniles implicated in the criminal justice system. The latest of those decisions came in 2021 with the Jones v. Mississippi case before the United States Supreme Court. The Court held that a sentencing court is not required to make a specific finding of permanent incorrigibility before sentencing the juvenile defendant to life without parole. This …

Neural Correlates Of Inhibitory Control And Associations With Cognitive Outcomes In Bangladeshi Children Exposed To Early Adversities, Eileen F. Sullivan, Wanze Xie, Stefania Conte, John E. Richards, Talat Shama, Rashidul Haque, William A. Petri, Charles A. Nelson

Faculty Publications

There is strong support for the view that children growing up in low-income homes typically evince poorer performance on tests of inhibitory control compared to those growing up in higher income homes. Unfortunately, the vast majority of the work documenting this association has been conducted in high-income countries. It is not yet known whether the mechanisms found to mediate this association would generalize to children in low- and middle-income countries, where the risks of exposure to extreme poverty and a wide range of both biological and psychosocial hazards may be greater. We examined relations among early adversity, neural correlates of …

Academic Senate - Agenda, 2/22/2022, Academic Senate

Academic Senate Agendas

No abstract provided.

Minutes, Curriculum Committee Meeting, Tuesday, February 22, 2022, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Compounds And Methods For Reducing Or Inhibiting Aggregation Of Proteins In A Subject, Jianfeng Cai, Chuanhai Cao

USF Patents

Disclosed herein are compounds for the treatment of neurodegenerative diseases and compositions comprising the same.

Women In Stem Fellowship: An Intersectional And Interdisciplinary Approach To Advancing Inclusion In The Sciences, Ina C. Seethaler, Gabriela Perez-Alvarado

Journal of the South Carolina Academy of Science

At our university, women-identified individuals make up 23% of students in STEM fields; less than 15% of them graduate with a STEM degree. Nationally, more than 40% of women who enter a STEM job leave it within fewer than ten years. Gendered issues within STEM industries have been identified, yet we are far from equal opportunities for all genders. In 2018, we—the director of Women’s and Gender Studies (WGS) with colleagues in Math, Computing Sciences, and Chemistry—received a $45,000 grant to create a “Women in STEM Fellowship.” The inclusion of WGS made the fellowship interdisciplinary, intersectional, and informed our decision-making …

The Planted Catalog: The Role Of The Botanical Garden In Botany, Douglas Tuers

Journal of the South Carolina Academy of Science

This article will investigate the role of the botanical garden in botany. What its role is and how it fills it. This article will take the Missouri Botanical Garden as a case study, drawing heavily from archival material compromised mostly of letters between Henry Shaw and the prominent botanists of his day. This study also draws on the prominent histories of the Missouri Botanical Garden. The analysis use the philosophical tradition around reference in logic and language. This study argues that the botanical garden is a bridge between locality and herbaria. The order of the flora travels to the locality …

Intramolecular Friedel-Crafts Addition Of Indoles To Tertiary Allylic Alcohols, Bryan H. Wakefield, Romie Barnes, Traeannah Brown, Ashley M. Jones, Victoria A. Knotts, Christina Martinetti

Journal of the South Carolina Academy of Science

An intermolecular Friedel-Crafts alkylation of indole and tertiary allylic alcohols has been developed. The allylic alcohols were synthesized using a two-step procedure, then exposure of these alcohols to diphenyl phosphate facilitated the desired annulation reaction. This reaction tolerated a variety of indole substitutions to yield 1H,2H,3H,4H-pyrido[1,2-a]indoles.

Systems And Processes For Early Detection Of Biological Ammonia Oxidation In Water Using Fluorometry, Julian Fairey, Thien Duc Do, Ashley Pifer, David G. Wahman

Patents Granted

This invention relates generally to a system and process for early detection of biological ammonia oxidation in water utilizing a fluorescence-based sensor and process. Various embodiments are configured to read increases in a fluorescence excitation-emission wavelength pair that is responsive to a period of time (days to weeks or even longer) prior to the onset of biological ammonia oxidation, which is considered to be a nitrification event. Fluorescence excitation/emission pairs that have proven to be reliable include a fluorescence excitation wavelength of about 230 nm and an emission wavelength of about 345 nm and an excitation wavelength of 325 and …

A Decade After Ariad: What Is The Written Description Standard For Emerging Bio-Pharma Patents?, Pu-Cheng (Leo) Huang

Washington Journal of Law, Technology & Arts

The Federal Circuit’s en banc decision in Ariad Pharms., Inc. v. Eli Lilly & Co. diverged from its previous interpretation of the “written description” requirement under 35 U.S.C. § 112. The new requirement mandates inventors to prove that they “actually invented the invention claimed.” The court observed that this new requirement is particularly onerous for biotechnological and chemical genus claims where few species have been reduced to practice. The new requirement asks inventors to disclose detailed descriptions for more than one species in the specification to support their genus claims. The heightened standard has massively affected front-end technology research. However, …

Development Of A Multivariate Model With Desirability-Based Optimization For Determination Of Atenolol And Hydrochlorothiazide By Eco-Friendly Hplc Method With Fluorescence Detection, Ekram Hany Mohamed, Ahmed Hemdan,, Naser F. Al-Tannak,

Pharmacy

Determination of a widely used antihypertensive combination of atenolol and hydrochlorothiazide was achieved by rapid and eco-friendly high-performance liquid chromatography method combined with fluorescence detection. The response surface methodology is conducive to the complete separation of the two drugs in a shorter analysis time. The separation of the mixture was achieved using an Inertsil C18 analytical column (150 × 4.6 mm, 5 µ). The mobile phase used was ethanol: potassium dihydrogen phosphate at pH 3 (65:35 v/v) and the flow rate was 0.7 mL/min. The fluorescence detector operated at excitation and emission wavelengths of 230 and 310 nm (atenolol) and …

Field Pea Diversity And Its Contribution To Farmers' Livelihoods In Northern Ethiopia, Yirga Gufi, Alemtsehay Tsegay, Morgan Ruelle, Kassa Teka, Sarah Tewolde-Berhan, Alison Power

Sustainability and Social Justice

Field pea is grown by smallholder farmers in Ethiopia as a source of food, fodder, income, and soil fertility. This study explores intraspecific diversity of field pea and its contribution to farmers' livelihoods in two agroecological zones of South Tigray and South Wollo, northeastern Ethiopia. Interviews were conducted with 168 farming households. The number of varieties and the Shannon Diversity Index (SDI) were higher in South Tigray (seven varieties, 0.35 SDI) than South Wollo (two varieties, 0.025 SDI). Farmers in South Tigray plant field pea during two growing seasons, allowing for integration of multiple varieties into their farming systems. The …

Clinical Validation Of A Spectroscopic Liquid Biopsy For Earlier Detection Of Brain Cancer., James M. Cameron, Paul M. Brennan, Georgios Antoniou, Holly J. Butler, Loren Christie, Justin J A Conn, Tom Curran, Ewan Gray, Mark G. Hegarty, Michael D. Jenkinson, Daniel Orringer, David S. Palmer, Alexandra Sala, Benjamin R. Smith, Matthew J. Baker

Manuscripts, Articles, Book Chapters and Other Papers

Background: Diagnostic delays impact the quality of life and survival of patients with brain tumors. Earlier and expeditious diagnoses in these patients are crucial to reduce the morbidities and mortalities associated with brain tumors. A simple, rapid blood test that can be administered easily in a primary care setting to efficiently identify symptomatic patients who are most likely to have a brain tumor would enable quicker referral to brain imaging for those who need it most.

Methods: Blood serum samples from 603 patients were prospectively collected and analyzed. Patients either had non-specific symptoms that could be indicative of a brain …

Costly Gadgets: Barriers To Market Entry And Price Competition For Generic Drug-Device Combinations In The United States, Michael S. Sinha

Minnesota Journal of Law, Science & Technology

No abstract provided.

Forecasting Neuromuscular Recovery After Anterior Cruciate Ligament Injury: Athlete Recovery Profiles With Generalized Additive Modeling, Matthew J. Jordan, Nathaniel Morris, Jeremiah Barnert, Drew Lawson, Isabel Aldrich Witt, Walter H Herzog

Research outputs 2022 to 2026

A retrospective analysis of longitudinally collected athlete monitoring data wasconducted to generate a model of neuromuscular recovery after anterior cruciateligament (ACL) injury and reconstruction (ACLR). Neuromuscular testing data in-cluding countermovement jump (CMJ) force‐time asymmetries and knee extensorstrength (maximum voluntary contractionext) asymmetries (between‐limb asymmetryindex—AI) were obtained from athletes with ACLR using semitendinosus (ST) au-tograft (n= 29; AI measurements: n= 494), bone patellar tendon bone autograft(n= 5; AI measurements:n= 88) and noninjured controls (n= 178; AI measurements:n= 3188). Explosive strength measured as the rate of torque development was alsocalculated. CMJ force‐time asymmetries were measured over discrete movementphases (eccentric deceleration phase, concentric phase). …

Cobalt Ferrite Nano-Composites For The Oxidation Of Phenols In Oil Refinery Wastewater, Amira Mohamed

Theses and Dissertations

Phenolic compounds have the tendency to persist in the environment over a long period making them a main source of concern because of their toxic characteristics towards humans and animals (Bruce et al., 1987). Therefore, existence of phenolic compounds in aquatic environment is unfavourable and as a result, many treatment techniques have been implemented to treat the wastewater produced from petroleum refineries. Petroleum refineries are among the top industries that produces significant quantities of high phenol concentration wastewater. Photo-catalysis is a promising and effective method to treat phenol present in oil refineries effluent. In this study, the photo-catalyst used is …

The Current State Of Gene Doping And The Future Of Gene Therapy Regulations, Sean Costa

San Diego International Law Journal

Genome editing, also referred to as “gene editing” or “gene therapy,” is no longer a theoretical eventuality of scientific progression; it is a reality of modern life. One of the numerous groups affected by this technology is athletes as “gene doping” becomes a more viable option to improve athletic performance each year. Some international agencies have begun to address the issues presented by gene doping, but there is no comprehensive international framework or regulations on the proper standards of use or punishment for those who abuse this new technology. International agencies must work together to establish regulations for human genome …

'Analogy-Based Comprehensive Diabetes Education' (Abcde) Improves Glycemic Control Of Diabetic Patients In An Underserved Population: Results Of A Retrospective Chart Analysis, Rajagopal V Sekhar

Faculty, Staff and Students Publications

Diabetes is the leading global cause for blindness, kidney failure and amputations. Preventing these complications requires optimal glycemic control, and it is imperative that diabetic patients understand the fundamental concepts of diabetes care. Although patients attend formal diabetes education classes, many do not comprehend basic concepts of diabetes, and are often noncompliant with diet, exercise and medications. A novel approach termed 'analogy-based comprehensive diabetes education' (ABCDE) was developed to educate HIV-patients with diabetes about basic concepts of diabetes care. The object of this manuscript is to report the results of a retrospective chart review on the impact of ABCDE on …