Digital Commons Network^™

Influence Of Saccharide Modifications On Heparin Lyase Iii Substrate Specificities, Jiandong Wu, Pradeep Chopra, Geert Jan Boons, Joseph Zaia

Chemical and Biochemical Engineering Faculty Research & Creative Works

A Library of 23 Synthetic Heparan Sulfate (HS) Oligosaccharides, Varying in Chain Length, Types, and Positions of Modifications, Was Used to Analyze the Substrate Specificities of Heparin Lyase III Enzymes from Both Flavobacterium Heparinum and Bacteroides Eggerthii. the Influence of Specific Modifications, Including N-Substitution, 2-O Sulfation, 6-O Sulfation, and 3-O Sulfation on Lyase III Digestion Was Examined Systematically. It Was Demonstrated that Lyase III from Both Sources Can Completely Digest Oligosaccharides Lacking O-Sulfates. 2-O Sulfation Completely Blocked Cleavage at the Corresponding Site; 6-O and 3-O Sulfation on Glucosamine Residues Inhibited Enzyme Activity. We Also Observed that There Are Differences in …

A New Way To Trace Sars-Cov-2 Variants Through Weighted Network Analysis Of Frequency Trajectories Of Mutations, Paul W. Bible, Qiang Huang, Qiang Zhang, Qiaoxing Liang, Fangfang Zheng, Ying Wang, Yuantao Hao, Yu Liu

Computer Science Faculty publications

Early detection of SARS-CoV-2 variants enables timely tracking of clinically important strains in order to inform the public health response. Current subtype-based variant surveillance depending on prior subtype assignment according to lag features and their continuous risk assessment may delay this process. We proposed a weighted network framework to model the frequency trajectories of mutations (FTMs) for SARS-CoV-2 variant tracing, without requiring prior subtype assignment. This framework modularizes the FTMs and conglomerates synchronous FTMs together to represent the variants. It also generates module clusters to unveil the epidemic stages and their contemporaneous variants. Eventually, the module-based variants are assessed by …

Now You See Me: “First” Records Of The Greater Amberjack Seriola Dumerili At Rapa Nui Range Extension Or Increased Scientific Effort?, Naiti Morales, Amy Rose Coghlan, Erin E. Easton, Alan M. Friedlander, James J. Herlan, Carlos F. Gaymer

School of Earth, Environmental, & Marine Sciences Faculty Publications

We report new records of the fisheries-harvested subtropical greater amberjack Seriola dumerili for the south-east Pacific Ocean. Previously, only one species of Seriola (the yellowtail amberjack Seriola lalandi) was scientifically recorded for Rapa Nui (also known as Easter Island) despite local fishers' asserting that three Seriola morphotypes are found in the region. Here we present the first 'scientific record' of what could be a pre-existing (albeit transient) species of the Rapa Nui ecoregion. Establishing the existing range limits of commercially and ecologically valuable species is key for observing climate-driven distribution shifts, and the inclusion of traditional ecological knowledge is likely …

Understanding Effects Of Permafrost Degradation And Coastal Erosion On Civil Infrastructure In Arctic Coastal Villages: A Community Survey And Knowledge Co-Production, Min Liew, Ming Xiao, Louise Farquharson, Dmitry Nicolsky, Anne Jensen, Vladimir Romanovsky, Jana Peirce, Lilian Alessa, Christopher Mccomb, Xiong Zhang, Benjamin Jones

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This paper presents the results of a community survey that was designed to better under-stand the effects of permafrost degradation and coastal erosion on civil infrastructure. Observations were collected from residents in four Arctic coastal communities: Point Lay, Wainwright, Utqiaġvik, and Kaktovik. All four communities are underlain by continuous ice-rich permafrost with varying degrees of degradation and coastal erosion. The types, locations, and periods of observed permafrost thaw and coastal erosion were elicited. Survey participants also reported the types of civil infrastructure being affected by permafrost degradation and coastal erosion and any damage to residential buildings. Most survey participants reported …

Prognostic And Predictive Biomarkers In Patients With Coronavirus Disease 2019 Treated With Tocilizumab In A Randomized Controlled Trial, Jennifer Tom, Min Bao, Larry Tsai, Aditi Qamra, David Summers, Montserrat Carrasco-Triguero, Jacqueline Mcbride, Carrie M Rosenberger, Celia J F Lin, William Stubbings, Kevin G Blyth, Jordi Carratalà, Bruno François, Thomas Benfield, Derrick Haslem, Paolo Bonfanti, Cor H Van Der Leest, Nidhi Rohatgi, Lothar Wiese, Charles Edouard Luyt, Farrah Kheradmand, Ivan O Rosas, Fang Cai

Faculty, Staff and Students Publications

OBJECTIVES: To explore candidate prognostic and predictive biomarkers identified in retrospective observational studies (interleukin-6, C-reactive protein, lactate dehydrogenase, ferritin, lymphocytes, monocytes, neutrophils, d-dimer, and platelets) in patients with coronavirus disease 2019 pneumonia after treatment with tocilizumab, an anti-interleukin-6 receptor antibody, using data from the COVACTA trial in patients hospitalized with severe coronavirus disease 2019 pneumonia.

DESIGN: Exploratory analysis from a multicenter, randomized, double-blind, placebo-controlled, phase 3 trial.

SETTING: Hospitals in North America and Europe.

PATIENTS: Adults hospitalized with severe coronavirus disease 2019 pneumonia receiving standard care.

INTERVENTION: Randomly assigned 2:1 to IV tocilizumab 8 mg/kg or placebo.

MEASUREMENTS AND MAIN …

Qu(E)Erying Evangelism: Growing A Community From The Outside In, Cheri Dinovo

WLU Press Books

“Qu(e)erying Evangelism: Growing a Community from the Outside In” is a look at the true meaning of evangelism. Evangelism is not growth or marketing and is not the ‘work’ of Christians converting others but instead is the calling of those who have been ‘othered’ converting those inside Churches. It is the act of the Divine through the marginalized from the outside/in.

The ‘others’ include 2SLGBTQ who have been, in many instances, abandoned by Churches. It gives the example of both a Church in downtown Toronto, the site of the first legalized same sex marriage in Canada and of Riverside Church …

C.T. Trowell Collection Of Roland M. Harper, Zach S. Henderson Library Special Collections

Finding Aids

This collection consists of photocopies of articles and book excerpts written by Roland M. Harper for publication in scholarly journals and various other botanical bulletins. Harper's works focus on botany, conservation, and social conditions, primarily in the southeastern United States. Spanning from 1900 - 2008, additional documents, photographs and audio visual materials pertaining to Roland M. Harper's family history is included.

Find this collection in the University Libraries' catalog.

Avian Orexin: Feed Intake Regulator Or Something Else?, Alison Ramser, Sami Dridi

Poultry Science Faculty Publications and Presentations

Originally named for its expression in the posterior hypothalamus in rats and after the Greek word for "appetite", hypocretin, or orexin, as it is known today, gained notoriety as a neuropeptide regulating feeding behavior, energy homeostasis, and sleep. Orexin has been proven to be involved in both central and peripheral control of neuroendocrine functions, energy balance, and metabolism. Since its discovery, its ability to increase appetite as well as regulate feeding behavior has been widely explored in mammalian food production animals such as cattle, pigs, and sheep. It is also linked to neurological disorders, leading to its intensive investigation in …

First Amendment Contradictions And Pathologies In Discourse, Erica Goldberg

School of Law Faculty Publications

A robust, principled application of the First Amendment produces contradictions that undermine the very justifications for free speech protections. Strong free speech protections are justified by the idea that rational, informed deliberation leads to peaceful decision-making, yet our marketplace of ideas is crowded with lies, reductive narratives, emotional appeals, and speech that leads to violence. Our current First Amendment model creates pathologies in discourse, which I term problems in speech quality and problems of speaker identity, that are exacerbated in our modern age of easy communication. The reason for these pathologies lies in the relationship between reason and emotion, both …

Current State Of Inclusion Education: A Cross-State Analysis Of Compliance, Teacher Certification, And Students With Disabilities Academic Outcomes, Emily Rose Winters

Doctoral Dissertations and Projects

Since passage of the Individuals with Disabilities Education Act (IDEA) there has been a legal requirement to provide students with disabilities the most inclusive education possible (Winchell et al., 2018) while Every Student Succeeds Act of 2015 requires that education be delivered by highly qualified teachers. Despite this, there have been minimal parameters set by the federal government in relation to inclusion education implementation or what constitutes a highly qualified teacher leading to significant variance in state inclusion education methods (Westling, 2019) and requirements for initial teaching certification or licensure (United States Department of Education, 2019; Youngs et al., 2003). …

Studying Acetylation Of Aconitase Isozymes By Genetic Code Expansion, Jessica Araujo, Sara Ottinger, Sumana Venkat, Qinglei Gan, Chenguang Fan

Chemistry & Biochemistry Faculty Publications and Presentations

Aconitase catalyzes the second reaction of the tricarboxylic acid cycle, the reversible conversion of citrate and isocitrate. Escherichia coli has two isoforms of aconitase, AcnA and AcnB. Acetylomic studies have identified acetylation at multiple lysine sites of both E. coli aconitase isozymes, but the impacts of acetylation on aconitases are unknown. In this study, we applied the genetic code expansion approach to produce 14 site-specifically acetylated aconitase variants. Enzyme assays and kinetic analyses showed that acetylation of AcnA K684 decreased the enzyme activity, while acetylation of AcnB K567 increased the enzyme activity. Further in vitro acetylation and deacetylation assays were …

Substance Abuse's Impact On Public Accounting, William Dennis Holmes

Doctoral Dissertations and Projects

A case study was performed to determine best practices for handling substance use disorder (SUD) when the problem occurs in business. SUD is a common problem that affects most businesses. The problem can result in high costs to businesses and is often difficult to navigate. The problem identified in the study was investigated by answering the primary research questions established in the planning stages of the study. An exhaustive literature review was performed on the topic, and common themes were discovered during a review of the literature. After the planning stage, the researcher performed a case study. Interviews of 23 …

The Effects Of Epistemic Beliefs On Undergraduate Students' Emotions And Attitudes Towards Genetically Modified Foods, David Andrew Lee

Doctoral Dissertations and Projects

Much research has explored socio-scientific issues (SSIs) in science instruction, including the connections between conceptions and attitude. Studies have also shown that epistemic beliefs affect epistemic emotions, which are a key component of students’ reaction to complex scientific topics. Correcting misconceptions can also result in emotional and attitude change, particularly surrounding the topic of genetically modified foods (GMFs). However, the impact of epistemic beliefs on emotions and attitude towards GMFs has largely gone unexplored. The purpose of this study is to examine the effects of epistemic beliefs on epistemic emotions and attitudes towards GMFs. This quantitative correlational study sampled 78 …

A Study Of K-12 Classroom Teachers' Concerns And Perceived Self-Efficacy In Implementing Inclusive Teaching Practices To Instruct Students With Disabilities, Pankaj Khazanchi

Doctoral Dissertations and Projects

Research over the past decade suggests teachers have low instructional self-efficacy/confidence and more concerns about implementing inclusive teaching practices. This quantitative correlational study explored whether reported concerns and demographic variables (gender, age, education, and years of teaching experience) predicts teachers’ instructional self-efficacy with students with disabilities. The Concerns about Inclusive Education and the Teachers’ Efficacy in Implementing Inclusive Practices scales were administered to 123 K-12 classroom teachers in Georgia. Data were subjected to hierarchical linear multiple regression to examine whether systematically adding select demographic variables and teachers’ concern scores to the overall model significantly improved the model’s ability to predict …

A Phenomenological Study Of Trauma-Informed Teaching During A Global Education Disruption, Angelique Susan Smith

Doctoral Dissertations and Projects

The purpose of this hermeneutical, phenomenological study described the experience of university educators using trauma-informed instructional practices during a global education disruption for university educators at Southeast University (pseudonym). The theory guiding this study is Richardson’s metatheory of resilience and resiliency (which describes an individual’s natural flow between homeostasis, through disruption, and adjunct to the disruption as part of the natural order of adaptation. The study addresses the following questions: How do university educators describe their experiences with trauma-informed teaching during a global education disruption? What formal strategies have university educators implemented to build social and emotional skills for students …

Application Of Natural Radioactivity For Hydrogeological And Environmental Assessment Of Groundwater In Ras Alkhaimah, Uae, Mohammed Nasser Abdullah Al-Saqri

Theses

Groundwater includes a certain concentration of natural radioactive isotopes of uranium (U) and its decay products (daughters) like radon (Rn). Defining the concentration levels, spatial distribution, and possible environmental impact of these isotopes in groundwater is vital for sustainable groundwater resources in the United Arab Emirates (UAE). This dissertation focuses on documenting the distribution and determining the probable environmental impact and sources of Uranium-235 (²³⁵U), Uranium-238 (²³⁸U), and Radon-222 (²²²Rn) in groundwater in the Northern part of the UAE and specifically in the Wadi Al Bih aquifer in Ras Al Khaimah Emirate. The sampled …

Investigating The Presence Of Cladocera Species Within The Wetlands Of Uae, Shamma Eisa Salem Shahdad Alneyadi

Theses

The wetlands ecosystems found in the Arabian Peninsula have been poorly investigated. Moreover, the available information about the presence of freshwater communities have been rarely documented. Although there are scattered records about the presence of freshwater Cladocera organisms within the Arabian Gulf countries; few of them have received proper taxonomic identification. Cladocera populations in freshwater bodies are always characterizing its water quality and other living invertebrates’ community. United Arab Emirates wetlands are among the ecosystems belonging to Ramsar convention for its conservation. The presence of both temporary and permanent freshwater area has been developed after the great interest to collect …

Does Cryptocurrency Hurt African Firms?, Mina Sami, Wael Abdallah

Faculty Journal Articles

This paper aimed to assess the effect of the cryptocurrency market on firms’ market value, especially on the sectoral level, in Africa. To reach the study’s main goal, the authors adopted the Panel-Corrected Standard Errors (PCSEs) and Panel Double-Clustered Standard Errors (PDCSEs). Using firm-level data, the results of this study can be summarized as follows: (a) The cryptocurrency market hurts the firm market value in Africa. (b) The firms operating across different sectors respond disproportionally to the cryptocurrency market. For instance, the sectors that offer low returns in Africa (industrial, energy, financial) negatively respond to the cryptocurrency market, while the …

Tadalafil Enhances Immune Signatures In Response To Neoadjuvant Nivolumab In Resectable Head And Neck Squamous Cell Carcinoma, Adam J. Luginbuhl, Jennifer Johnson, Larry Harshyne,, Alban J Linnenbach, Sanket Kumar Shukla, Angela Alnemri, Gaurav Kumar, David Cognetti, Joseph Curry, Nikita Kotlov, Zoya Antysheva, Sandrine Degryse, Kyle Mannion, Michael K Gibson, James Netterville, Brandee Brown, Rita S. Axelrod, Ralph G. Zinner, Madalina Tuluc, Stacey Gargano, Benjamin E Leiby, Ayako Shimada, M G Mahoney, Ubaldo E. Martinez-Outshoorn, Ulrich Rodeck, Young J Kim, Andrew P. South, Athanassios Argiris

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Purpose: We hypothesize that the addition of the phosphodiesterase-5 inhibitor tadalafil to the PD-1 inhibitor nivolumab, is safe and will augment immune-mediated antitumor responses in previously untreated squamous cell carcinoma of the head and neck (HNSCC).

Patients and methods: We conducted a two-arm multi-institutional neoadjuvant randomized trial in any-stage resectable HNSCC (NCT03238365). Patients were stratified at randomization by human papillomavirus (HPV) status. Patients in both arms received nivolumab 240 mg intravenously on days 1 and 15 followed by surgery on day 28. Those in the combination therapy arm also received tadalafil 10 mg orally once daily for 4 weeks. Imaging, …

Analysing Tweets On Covid-19 Vaccine : A Text Mining Approach, Swetha Gottipati, Debashis Guha

Research Collection School Of Computing and Information Systems

The COVID-19 pandemic has caused large scale health, economic, and social crisis. Scientists throughout the globe have been working on producing effective vaccines to combat this pandemic. COVID-19 vaccine release started in 2020, and low take-up rates among the public have been observed initially. There has been a soar in social media data on vaccines. This paper presents a comprehensive analysis of COVID-19 vaccine-related tweets. Sentiments shared by people through tweets and common topics have been extracted using classification and sentiment analysis. Our results showed a higher negative sentiment when the pandemic was declared, and it gradually changed to positive …

Towards Efficient Annotations For A Human-Ai Collaborative, Clinical Decision Support System: A Case Study On Physical Stroke Rehabilitation Assessment, Min Hun Lee, Daniel P. Siewiorek, Asim Smailagic, Alexandre Bernardino, Sergi Bermúdez I Badia

Research Collection School Of Computing and Information Systems

Artificial intelligence (AI) and machine learning (ML) algorithms are increasingly being explored to support various decision-making tasks in health (e.g. rehabilitation assessment). However, the development of such AI/ML-based decision support systems is challenging due to the expensive process to collect an annotated dataset. In this paper, we describe the development process of a human-AI collaborative, clinical decision support system that augments an ML model with a rule-based (RB) model from domain experts. We conducted its empirical evaluation in the context of assessing physical stroke rehabilitation with the dataset of three exercises from 15 post-stroke survivors and therapists. Our results bring …

Effect Of Dicamba On Reproductive Development In Corn And Rice, Mason Castner, Jason K. Norsworthy, L. Tom Barber, Trenton Lee Roberts, Edward E. Gbur

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Research has been published regarding the effects of sublethal dicamba rates applied at different growth stages in soybean [Glycine max (L.) Merr.]; however, there is limited research on the effect of dicamba on reproductive growth in corn (Zea mays L.) and rice (Oryza sativa L.). Experiments were conducted in 2018 and 2019 to determine the potential consequences of dicamba exposure to reproductive stages of corn and rice. Dicamba was applied at 0.56, 5.6, 56, and 560 g ae ha^–1, with a 1X rate being 560 g ae ha^–1. Each rate was applied at …

Soil Organic Carbon And Nutrients Affected By Tree Species And Poultry Litter In A 17-Year Agroforestry Site, Helen C.S. Amorim, Amanda J. Ashworth, Yuri L. Zinn, Thomas J. Sauer

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Tree species and fertilization sources may affect the soil organic carbon (SOC) and fertility in agroforestry (AF) systems in temperate regions, but this remains unexplored. This study assesses the longitudinal trends in the SOC and major nutrients in a 17-year AF site established on an Ultisol in Fayetteville, AR. We evaluated how management and fertilization (mineral vs. organic) affect the soil’s physical and chemical properties using the tree species: red oak (Quercus rubra L.) and pecan Carya illinoinensis (Wangenh.) K. Koch. Long-term applications of poultry litter increased the soil pH, whereas the Mg and S concentrations decreased compared to …

High Resistance To Quinclorac In Multiple-Resistant Echinochloa Colona Associated With Elevated Stress Tolerance Gene Expression And Enriched Xenobiotic Detoxification Pathway, Gulab Rangani, Christopher E. Rouse, Christopher Saski, Rooksana E. Noorai, Vijay Shankar, Amy L. Lawton-Rauh, Isabel S. Werle, Nilda Roma-Burgos

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Echinochloa colona and other species in this genus are a threat to global rice production and food security. Quinclorac, an auxin mimic, is a common herbicide for grass weed control in rice, and Echinochloa spp. have evolved resistance to it. The complete mode of quinclorac action and subsequent evolution of resistance is not fully understood. We analyzed the de novo transcriptome of multiple-herbicide-resistant (ECO-R) and herbicide-susceptible genotypes in response to quinclorac. Several biological processes were constitutively upregulated in ECO-R, including carbon metabolism, photosynthesis, and ureide metabolism, indicating improved metabolic efficiency. The transcriptional change in ECO-R following quinclorac treatment indicates an …

Measurable Microcystin In Ozark Streams Was Rare During Summer 2018 Baseflow Conditions, Bradley J. Austin, Brian E. Haggard

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Accelerated eutrophication due to human activity has been linked to an increase in the occurrence of cyanobacteria in freshwater systems. The purpose of this study was to document the occurrence of microcystin, a common cyanotoxin, within northwest Arkansas streams. Twenty streams were sampled from May through October 2018, and water and periphyton samples were analyzed for microcystin and chlorophyll-a (CHL-a). Mean microcystin concentrations in water samples were low across sites, ranging from < 0.10 to 0.21 μg L⁻¹. Mean microcystin in the periphyton across sites ranged from 2.6 to 9.9 μg m⁻² and were within values observed in the literature. …

Sizing An Open-Channel Woodchip Bioreactor To Treat Nitrate From Agricultural Tile Drainage And Achieve Water Quality Targets, Pam Krone, Ross Clark, Jason Adelaars, Mason Leandro, Alex Henson, Jessica Williamson, Heather Bischel, Olivia Wrightwood, Fred Watson

Faculty Research, Scholarly, and Creative Activity

Woodchip bioreactors are capable of removing nitrate from agricultural runoff and subsurface tile drain water, alleviating human health hazards and harmful discharge to the environment. Water pumped from agricultural tile drain sumps to nearby ditches or channels could be cost-effectively diverted through a woodchip bioreactor to remove nitrate prior to discharge into local waterways. Sizing the bioreactor to achieve targeted outlet concentrations within a minimum footprint is important to minimizing cost. Determining the necessary bioreactor size should involve a hydrological component as well as reaction type and rates. We measured inflow and outflow nitrate concentrations in a pumped open-channel woodchip …

Attribution Of Space-Time Variability In Global-Ocean Dissolved Inorganic Carbon, Dustin Carroll, Dimitris Menemenlis, Stephanie Dutkiewicz, Jonathan M. Lauderdale, Jess F. Adkins, Kevin W. Bowman, Holger Brix, Ian Fenty, Michelle M. Gierach, Chris Hill, Oliver Jahn, Peter Landschützer, Manfredi Manizza, Matt R. Mazloff, Charles E. Miller, David S. Schimel, Ariane Verdy, Daniel B. Whitt, Hong Zhang

Faculty Research, Scholarly, and Creative Activity

The inventory and variability of oceanic dissolved inorganic carbon (DIC) is driven by the interplay of physical, chemical, and biological processes. Quantifying the spatiotemporal variability of these drivers is crucial for a mechanistic understanding of the ocean carbon sink and its future trajectory. Here, we use the Estimating the Circulation and Climate of the Ocean-Darwin ocean biogeochemistry state estimate to generate a global-ocean, data-constrained DIC budget and investigate how spatial and seasonal-to-interannual variability in three-dimensional circulation, air-sea CO2 flux, and biological processes have modulated the ocean sink for 1995–2018. Our results demonstrate substantial compensation between budget terms, resulting in distinct …

Monitoring Sars-Cov-2 In Wastewater During New York City's Second Wave Of Covid-19: Sewershed-Level Trends And Relationships To Publicly Available Clinical Testing Data, Catherine Hoar, Francoise Chauvin, Alexander Clare, Hope Mcgibbon, Esmeraldo Castro, Davida S. Smyth, Et Al.

Biology Faculty Publications (Archived)

New York City's wastewater monitoring program tracked trends in sewershed-level SARS-CoV-2 loads starting in the fall of 2020, just before the start of the city's second wave of the COVID-19 outbreak. During a five-month study period, from November 8, 2020 to April 11, 2021, viral loads in influent wastewater from each of New York City's 14 wastewater treatment plants were measured and compared to new laboratory-confirmed COVID-19 cases for the populations in each corresponding sewershed, estimated from publicly available clinical testing data. We found significant positive correlations between viral loads in wastewater and new COVID-19 cases. The strength of the …

Rural Older Female Family Caregivers Lived Experiences In The Context Of Caregiving For Those With Ad/Adrd During The Covid-19 Pandemic, Candace Harrington, Cheryl Witt

Sigma Foundation for Nursing Research Grant Reports

This qualitative study aimed to understand how COVID-19 affects older female caregivers' lived experience, ongoing capacity, and willingness to provide care for their loved one(s) with AD/ADRD.

Bisphenol A Affects Neurodevelopmental Gene Expression, Cognitive Function, And Neuromuscular Synaptic Morphology In Drosophila Melanogaster, Chloe Welch, Eden Johnson, Angelina Tupikova, Judith Anderson, Brendan Tinsley, Johnathan Newman, Erin Widman, Adam Alfareh, Alexandra Davis, Lucero Rodriguez, Clayton Visger, Justin P. Miller-Schulze, Wendy Lee, Kimberly Mulligan

Faculty Research, Scholarly, and Creative Activity

Bisphenol A (BPA) is an environmentally prevalent endocrine disrupting chemical that can impact human health and may be an environmental risk factor for neurodevelopmental disorders. BPA has been associated with behavioral impairment in children and a variety of neurodevelopmental phenotypes in model organisms. We used Drosophila melanogaster to explore the consequences of developmental BPA exposure on gene expression, cognitive function, and synapse development. Our transcriptome analysis indicated neurodevelopmentally relevant genes were predominantly downregulated by BPA. Among the misregulated genes were those with roles in learning, memory, and synapse development, as well as orthologs of human genes associated with neurodevelopmental and …