Digital Commons Network^™

A Cellular And Molecular Atlas Reveals The Basis Of Chytrid Development, Davis Laundon, Nathan Chrismas, Kimberley Bird, Seth Thomas, Thomas Mock, Michael Cunliffe

School of Biological and Marine Sciences

The chytrids (phylum Chytridiomycota) are a major fungal lineage of ecological and evolutionary importance. Despite their importance, many fundamental aspects of chytrid developmental and cell biology remain poorly understood. To address these knowledge gaps, we combined quantitative volume electron microscopy and comparative transcriptome profiling to create an ‘atlas’ of the cellular and molecular basis of the chytrid life cycle, using the model chytrid Rhizoclosmatium globosum. From our developmental atlas, we describe the transition from the transcriptionally inactive free-swimming zoospore to the more biologically complex germling, and show that lipid processing is multifaceted and dynamic throughout the life cycle. We demonstrate …

Sedative, Analgesic And Behavioral Changes Of Caudal Epidural Injection Of Xylazine, Magnesium Sulphate In Egyptian Water Buffalo (Bubalus Bubalis), Ahmed Khalil, Atef Abd Al Galil, Mohamed Zeineldin, Seham Abo-Korae, Ahmed Sabek

Mansoura Veterinary Medical Journal

Objective: To assess and compare the effects of epidural xylazine (XY), magnesium sulphate (MG) and their combination (XY-MG) in buffalo. Design: Crossover study Animals: Seven healthy, non-pregnant buffalo Procedures: Buffaloes were allocated into one of three groups in a prospective randomized crossover design with two weeks washout period as the following: XY group, MG group and XY-MG group. The sedative, analgesic, and behavioral effects of XY, MG and their combination were evaluated prior to administration and at then after injection at 5, 10, 15, 30, 45, 60, 90 120, 150, 180, and 210 minutes. Results: Clinical and hematological variables were …

Evaluation Of Diaphragmatic Electromyography Of Cervical Spinal Cord Hemi Section In Rat Model, Samah Fouad, Shaymaa Rezk, Awad Rizk, Esam Mosbah, Basem Awad

Mansoura Veterinary Medical Journal

Objective: Estimation the degree of induced traumatic cervical segments damage using Electromyography (EMG) of the two diaphragmatic pillars separately in rat model. Design: Prospective controlled study.Animals: sixteen Sprague dawely rats were divided into 2 groups (8 rats in each group).Procedures: Cervical hemi section was surgically induced by a lateral cord section below the cervical dorsal root number 2 with micro scalpel. After 28 days post-injury, EMG record was done at the two diaphragmatic crural regions, followed by histopathological and immunohistochemical examinations. Results: There was significant decrease in mean integrated EMG activity of LT diaphragmatic muscles than RT one in the …

Predation In Many Dimensions: Spatial Context Is Important For Meaningful Functional Response Experiments, Steven A. Juliano, Jonah A. Goughnour, Geoffrey D. Ower

Faculty Publications – Biological Sciences

For simplicity and to minimize variation, functional response experiments frequently use environments of simple physical structure and small size. Less attention is paid to similarity of the experimental environment to the natural environment where predation occurs. Assumptions about predator and prey use of space are often implied in the choice of experimental environment. We illustrate how these assumptions may affect conclusions with an experiment testing how arena size affects a functional response. Toxorhynchites rutilus preyed upon larval Culex restuans in containers differing in volume by 15x, but spanning a similar range of prey/liter. The most plausible Type II model included …

Unraveling The Link Between Simulation Ehr Training And Task Performance: The Mediation Role Of Stress, Murad Moqbel, Vanessa Garza Clark, Aroop K. Pal, Lauren Pulino

Information Systems Faculty Publications

Past research has explored the link between computer-mediated communication (CMC) and task performance, but it remains unclear how (i.e., under what mechanisms) CMC impacts task performance. Drawing on media naturalness theory and the stimulus-organism-response model as our theoretical framework, we develop a research model and describe how simulation-based EHR training (a type of CMC) can improve EHR-based task performance by mitigating stress. We empirically test the model with a unique experimental dataset from EHR lab assessment and questionnaires that 225 participants completed. The structural equation modeling analysis results show that simulation EHR training helped improve EHR-based task performance (both effectiveness …

Cognitive Control Processes In Behavior Therapy For Youth With Tourette’S Disorder, Joseph F. Mcguire, Alexandra Sturm, Emily J. Ricketts, Gabrielle E. Montalbano, Susanna Chang, Douglas W. Woods, James Mccracken, John Piacentini

Psychological Science Faculty Works

Background

Cognitive control processes are implicated in the behavioral treatment of Tourette’s disorder (TD). However, the influence of these processes on treatment outcomes has received minimal attention. This study examined whether cognitive control processes and/or tic suppression predicted reductions in tic severity and treatment response to behavior therapy.

Method

Fifty-three youth with TD or a pervasive tic disorder participated in a randomized wait list-controlled trial of behavior therapy. Following a baseline assessment to evaluate psychiatric diagnoses, tic severity, and cognitive control processes (e.g., response selection, inhibition, and suppression), youth were randomly assigned to receive eight sessions of behavior therapy ( …

Collective Cognitive Capital, Emily R. D. Murphy

William & Mary Law Review

This Article calls for a new project for law and neuroscience. It outlines a structural, not individual, application of brain and behavioral science that is aligned with the general goal of basic science research: improving the lives of citizens with a better understanding of the human experience. It asks brain and behavioral science to move explicitly into public policy territory, and specifically onto ground more traditionally occupied by economists—but in ways the project of “behavioral economics” has not yet ventured. Put simply, policy analysts should focus on brains—“collective cognitive capital”—with the same intensity with which they focus on money, rights, …

The Diversity Of Norm Psychologies: A Challenge For The Law, Paul Sheldon Davies

William & Mary Law Review

Can we craft a coherent set of laws applicable to populations with deep cultural diversity? The full force of this question—call it the generalization challenge—has emerged recently thanks to advances in the sciences of the human, especially theories of neuroscience and psychology framed by theories of biological and especially cultural evolution. The goal of this Article is to describe enough of those advances to make clear the force of the challenge. The motivation is simple: as we endeavor to imagine the future of law in light of discoveries in neuroscience and related disciplines, being apprised of the generalization challenge may …

Neuroscience And Criminal Justice: Time For A "Copernican Revolution"?, John S. Callender

William & Mary Law Review

The main purpose of this Article is to argue for a fundamental change in the conceptual orientation of criminal justice: from one based on concepts such as free will, desert, and moral responsibility, to one based on empirical science. The Article describes research in behavioral genetics, acquired brain injuries, and psychological traumatization in relation to criminality. This research has reached a level of development at which the traditional approach to criminality is no longer tenable and should be discarded. I argue that mental health legislation provides a model that could be adapted and applied to offenders.

Neuroscience, Criminal Sentencing, And Human Rights, Elizabeth Shaw

William & Mary Law Review

This Article discusses ways in which neuroscience should inform criminal sentencing in the future. Specifically, it compares the ethical permissibility of traditional forms of punishment, such as incarceration, on the one hand, and rehabilitative “neurointerventions” on the other. Rehabilitative neurointerventions are interventions that aim directly to modify brain activity in order to reduce reoffending. Various jurisdictions are already using techniques that could be classed as neurointerventions, and research suggests that, potentially, an even wider range of rehabilitative neurointerventions may be developed. This Article examines the role of human rights (in particular, the moral right to mental integrity and the legal …

An Abductive Argument From Depression And Anxiety To Christian Personal Holiness, Kelly Douglas Burchett

Masters Theses

The science on pathological depression and anxiety (D&A) describes religion and spirituality's (R/S) insulating and immunizing effects in roughly 72 to 85 percent of all relevant articles. But the descriptivism of science cannot assign any normative value to a theological worldview. Deductive logic favors theism via Leibnizian contingency, Kalām cosmology, objective morality, fine-tuning of the universe, and abstract conceptualism. The information in DNA, the irreducible complexity of intracellular machinery, the improbability of folded proteins, and the support for common modular design over common ancestry establish a design inference for all of life. Unguided naturalistic simulations fail to surmount the complexity …

Naltrexone Implant For Opioid Use Disorder, Amber N. Edinoff, Catherine A. Nix, Claudia V. Orellana, Samantha M. Stpierre, Erin A. Crane, Blaine T. Bulloch, Elyse M. Cornett, Rachel L. Kozinn, Adam M. Kaye, Kevin S. Murnane, Alan David Kaye

School of Pharmacy Faculty Articles

The continued rise in the availability of illicit opioids and opioid-related deaths in the United States has left physicians, researchers, and lawmakers desperate for solutions to this ongoing epidemic. The research into therapeutic options for the treatment of opioid use disorder (OUD) began with the introduction of methadone in the 1960s. The approval of oral naltrexone initially showed much promise, as the drug was observed to be highly potent in antagonizing the effects of opioids while producing no opioid agonist effects of its own and having a favorable side effect profile. Patients that routinely take their naltrexone reported fewer days …

The Supreme Court’S Chief Justice Of Intellectual Property Law, Robert W. Gomulkiewicz

Nevada Law Journal

Justice Clarence Thomas is one of the most recognizable members of the United States Supreme Court. Many people recall his stormy Senate confirmation hearing and notice his fiery dissenting opinions that call on the Court to reflect the original public meaning of the Constitution. Yet observers have missed one of Justice Thomas’s most significant contributions to the Court—his intellectual property law jurisprudence. Justice Thomas has authored more majority opinions in intellectual property cases than any other Justice in the Roberts Court era and now ranks as the most prolific author of patent law opinions in the history of the Supreme …

Modeling The Caselaw Access Project: Lessons For Market Power And The Antitrust–Regulation Balance, Felix B. Chang, Erin Mccabe, James Lee

Nevada Law Journal

This Article applies computational legal methods to antitrust caselaw. We introduce modifications to topic modeling that streamline big data legal analysis. Topic modeling, an algorithm that maps the statistical relationships among words, is quickly gaining traction in law. Yet its adherents have overlooked criticisms of the tool from computer science and digital humanities, especially around decontextualization.

We utilize aggregated modeling, an improvement over traditional topic models, to analyze two corpora of antitrust decisions extracted from the Caselaw Access Project. One corpus covers market power cases, while the other features the terms ‘antitrust’ and ‘regulation.’

Though technical advances have made the …

Inhalation Injury Is Associated With Endotheliopathy And Abnormal Fibrinolytic Phenotypes In Burn Patients: A Cohort Study, John W. Keyloun, Tuan D. Le, Kathleen E. Brummel-Ziedins, Melissa M. Mclawhorn, Maria C. Bravo, Thomas Orfeo, Laura S. Johnson, Lauren T. Moffatt, Anthony E. Pusateri, Jeffrey W. Shupp

School of Medicine Faculty Publications and Presentations

Burn injury is associated with endothelial dysfunction and coagulopathy and concomitant inhalation injury (IHI) increases morbidity and mortality. The aim of this work is to identify associations between IHI, coagulation homeostasis, vascular endothelium, and clinical outcomes in burn patients. One hundred and twelve patients presenting to a regional burn center were included in this retrospective cohort study. Whole blood was collected at set intervals from admission through 24 hours and underwent viscoelastic assay with rapid thromboelastography (rTEG). Syndecan-1 (SDC-1) on admission was quantified by ELISA. Patients were grouped by the presence (n = 28) or absence (n = 84) of …

Effect Of Incorporation Of Bioactive Hydroxyapatite Nano-Rods In Self-Etch Adhesive On Microleakage, Nanoleakage Pattern And Elemental Analysis Of Resin/Dentin Interface, Samaher M. Taha, Hamdi H. Hammama, Salah H. Mahmoud

Mansoura Journal of Dentistry

Objective: To compare the effect of four types of adhesives immediately and after 6 months storage in artificial saliva followed by thermocycling (2000 cycle) on microleakage patterns, the nanoleakage pattern, and elemental analysis of adhesive interface. Materials and Methods: A total of 120 extracted sound human permanent molars were selected. And assigned into 4 groups according to adhesive types (one step-self-etch (1S-SE) adhesive, modified self-etch adhesive with hydroxyapatite nanorods (HA-NR), universal adhesive, resin-modified glass ionomer-based adhesive). Each group was further subdivided into two subgroups according to time of testing, (a) immediately evaluated, (b) was subjected to the 6 months storage …

Biogeosciences Perspectives On Integrated, Coordinated, Open, Networked (Icon) Science, D. Dwivedi, A. L.D. Santos, M. A. Barnard, T. M. Crimmins, A. Malhotra, K. A. Rod, K. S. Aho, S. M. Bell, B. Bomfim, F. Q. Brearley, H. Cadillo-Quiroz, J. Chen, C. M. Gough, E. B. Graham, C. R. Hakkenberg, L. Haygood, G. Koren, E. A. Lilleskov, L. K. Meredith, S. Naeher, Z. L. Nickerson, O. Pourret, H. S. Song, M. Stahl, N. Taş, R. Vargas, S. Weintraub-Leff

Department of Agricultural and Biological Systems Engineering: Faculty Publications

This article is composed of three independent commentaries about the state of Integrated, Coordinated, Open, Networked (ICON) principles in the American Geophysical Union Biogeosciences section, and discussion on the opportunities and challenges of adopting them. Each commentary focuses on a different topic: (a) Global collaboration, technology transfer, and application (Section 2), (b) Community engagement, community science, education, and stakeholder involvement (Section 3), and (c) Field, experimental, remote sensing, and real-time data research and application (Section 4). We discuss needs and strategies for implementing ICON and outline short- and long-term goals. The inclusion of global data and international community engagement are …

Instructional Models For Course-Based Research Experience (Cre) Teaching, David I. Hanauer, Mark J. Graham, Rachel J. Arnold, Mary A. Ayuk, Mitchell F. Balish, Andrea R. Beyer, Kristen A. Butela, Christine A. Byrum, Catherine P. Chia, Hui Min Chung, Kari L. Clase, Stephanie Conant, Roy J. Coomans, Tom D'Elia, Jason Diaz, Arturo Diaz, Jean A. Doty, Nicholas P. Edgington, Dustin C. Edwards, Elvira Eivazova, Christine B. Emmons, Kayla M. Fast, Viknesh Sivanathan, And About 50 Others

School of Biological Sciences: Faculty Publications

The course-based research experience (CRE) with its documented educational benefits is increasingly being implemented in science, technology, engineering, and mathematics education. This article reports on a study that was done over a period of 3 years to explicate the instructional processes involved in teaching an undergraduate CRE. One hundred and two instructors from the established and large multi-institutional SEA-PHAGES program were surveyed for their understanding of the aims and practices of CRE teaching. This was followed by large-scale feedback sessions with the cohort of instructors at the annual SEA Faculty Meeting and subsequently with a small focus group of expert …

Immortal Plain Gut Sutures: A Case Report, Hannah J. Anderson, Kathryn Lynn, Raziyeh Mahmoudzadeh, Tatyana Milman, Manish Jain, Sunir J Garg

Wills Eye Hospital Papers

Purpose: We report the case of a 79-year-old male who presented with irritation and foreign body sensation due to the subconjunctival plain gut sutures that did not dissolve three years after undergoing pars plana vitrectomy (PPV) for macular hole repair.

Observation: A 79-year-old male presented with foreign body sensation and irritation in his left eye. On slit lamp examination, the source of the foreign body sensation was two apparently intact plain gut sutures were visible under the conjunctiva, nasal and temporal to the cornea. These plain gut sutures were placed at the conclusion of PPV surgery three years prior to …

Assessing Pre-Literacy Behaviors In Infants And Toddlers: Psychometric Evaluation Of The Infant Toddler Literacy Assessment (Itla-3), Barbara J. Jackson, Christine Marvin, Amy J. Encinger, Nicole Buchholz, Becky Zessin

Department of Special Education and Communication Disorders: Faculty Publications

Assessment of emerging literacy in young children is generally limited to either skill development in children over 3 years of age or the quality and context of young children’s early literacy experiences. Although there has been promotion of their early literacy experiences, assessment of emerging pre-literacy behaviors in children younger than 3 years has yet to be organized into a single tool.

Preliminary work on the Infant Toddler Literacy Assessment (ITLA) has progressed through initial steps of scale development and shown promise as a criterionbased, standardized assessment for tracking children’s pre-literacy behaviors and guiding practitioners in supporting development of those …

Habitat Restoration Restores Underwater Soundscapes And Larval Recruitment, Jack Butler, Emily R. Anderson, Mark J. Butler

Biological Sciences Faculty Publications

Habitat degradation alters many ecosystem processes, and the potential for the reestablishment of ecosystem function through restoration is an area of active research. Among marine systems, coastal habitats are particularly vulnerable to anthropogenic degradation and, in response, are the focus of marine ecological restoration. One of the crucial functions of structurally complex coastal habitats (e.g., saltmarshes, seagrass meadows, kelp forests, coral reefs) are as nurseries to coastal and offshore species, many of whose larvae utilize sound to locate suitable nursery habitat. However, the effect of habitat degradation and subsequent restoration on underwater soundscapes and their function as navigational cues for …

American Heart Association Epi|Lifestyle Scientific Sessions: 2021 Meeting Highlights, Ruth Alma Turkson-Ocran, Kathryn Foti, Anika L. Hines, Debora Kamin Mukaz, Hyunju Kim, Samantha Martin, Anum Minhas, Faye L. Norby, Oluwabunmi Ogungbe, Alexander C. Razavi, Mary R. Rooney, Elisabeth L.P. Sattler, Jewel Scott Phd, Rn, Fnp-C, Alvin G. Thomas, Curtis Tilves, Amelia S. Wallace, Frances M. Wang, Mingyu Zhang, Pamela L. Lutsey, Kristie J. Lancaster

Faculty Publications

No abstract provided.

Riding The Wave: Reactive Vector-Borne Disease Policy Renders The United States Vulnerable To Outbreaks And Insecticide Resistance, Kyndall C. Dye-Braumuller, Jennifer R. Gordon, Kaci Mccoy, Danielle Johnson, Rhoel Dinglasan, Melissa Nolan Ph.D., Mph

Faculty Publications

Funding for vector-borne disease surveillance, management, and research is cyclical and reactive in the United States. The subsequent effects have yielded gross inequities nationally that unintentionally support recurrent outbreaks. This policy forum is comprised of four primary subsections that collectively identify specific areas for improvement and offer innovative solutions to address national inadequacies in vector borne disease policy and infrastructure.

If Dentistry's Social Contract With America Could Talk, Chester Gary Dds, Jd

The New York State Dental Journal

Dentistry must make running the business of dental practices compatible with professional responsibility.

Prolonged Glycemic Adaptation Following Transition From A Low- To High-Carbohydrate Diet: A Randomized Controlled Feeding Trial, Lisa T Jansen, Nianlan Yang, Julia M W Wong, Tapan Mehta, David B Allison, David S Ludwig, Cara B Ebbeling

Children’s Nutrition Research Center Staff Publications

Objective: Consuming ≥150 g/day carbohydrate is recommended for 3 days before an oral glucose tolerance test (OGTT) for diabetes diagnosis. For evaluation of this recommendation, time courses of glycemic changes following transition from a very-low-carbohydrate (VLC) to high-carbohydrate diet were assessed with continuous glucose monitoring (CGM).

Research design and methods: After achieving a weight loss target of 15% (±3%) on the run-in VLC diet, participants (18-50 years old, BMI ≥27 kg/m2) were randomly assigned for 10 weeks to one of three isoenergetic diets: VLC (5% carbohydrate and 77% fat); high carbohydrate, high starch (HC-Starch) (57% carbohydrate and 25% fat, including …

Treatment Of Peri-Implant Soft Tissue Deficiency Around A Narrow Diameter Implant With Subepithelial Connective Tissue Graft: A Case Report, Jaewon Kim Dds, Ms, Phd, Abhiram Maddi Dds Msc Phd

The New York State Dental Journal

Narrow diameter implants and mini-implants are preferred by dentists for restoration of missing teeth on narrow ridges. However, such implants are associated with long-term complications including soft tissue deficiencies. This case report describes a novel approach using a connective tissue graft to resolve peri-implant mucositis. A 66-year old male patient presented with inflammation and abscess in relation to a mini-implant, at the upper left incisor, on the facial aspect. Deficiencies of keratinized tissue and width of attached gingiva were observed. Surgical management was performed using subepithelial connective tissue. An 18-month follow up showed increased width of attached gingiva at the …

Simple Lipoma Mimicking Oral Infiltrating Lipoma: Case Report, Moacyr Tadeu V. Rodrigues Dds, Msc, Judson N. Brasil Dds, Gabriel A. Guillen Dds, Msc, Cláudio F. Nóia Dds, Phd

The New York State Dental Journal

Lipomas are common soft tissue neoplasms, usually present in the trunk and proximal portions of the extremities and less frequent in the mouth. We reported the case of a 51-year-old patient, affected by an intra/extra-oral swelling for 8 months. Aspiration, surgical excision and histopathological examination confirmed that it was a simple oral lipoma, although clinically and surgically, it mimicked an infiltrating lipoma. Conservative surgical treatment, preferably by an intra-oral approach provides less morbidity and less sequelae for patients.

Papillon-Lefevre Syndrome: A Case Study Of Two Siblings, Babak Bina Dmd, Boris Zats Dds, Tom Rubinstein Dmd

The New York State Dental Journal

Papillon-LeFevre Syndrome (PLS) is a rare autosomal recessive disease, associated with palmar-plantar hyperkeratosis and premature loss of both deciduous and permanent teeth. Treatment of this disease continues to be a challenge to the medical and dental professions. The following is a case report of two siblings of Chinese origin, diagnosed with Papillon-LeFevre syndrome and follows them for 10 subsequent years.

Atypical Tuning And Amplification Mechanisms In Gecko Auditory Hair Cells, Maryline Beurg, Tony Gamble, Aaron H. Griffing, Robert Fettiplace

Biological Sciences Faculty Research and Publications

The auditory papilla of geckos contains two zones of sensory hair cells, one covered by a continuous tectorial membrane affixed to the hair bundles and the other by discrete tectorial sallets each surmounting a transverse row of bundles. Gecko papillae are thought to encode sound frequencies up to 5 kHz, but little is known about the hair cell electrical properties or their role in frequency tuning. We recorded from hair cells in the isolated auditory papilla of the crested gecko, Correlophus ciliatus, and found that in both the nonsalletal region and part of the salletal region, the cells displayed …

Making (Remote) Sense Of Lianas, Geertje M. F. Van Der Heijden, Ashley D. C. Proctor, Kim Calders, Chris J. Chandler, Richard Field, Giles M. Foody, Sruthi M. Krishna Moorthy, Stefan A. Schnitzer, Catherine E. Waite, Doreed S. Boyd

Biological Sciences Faculty Research and Publications

1. Lianas (woody vines) are abundant and diverse, particularly in tropical ecosystems. Lianas use trees for structural support to reach the forest canopy, often putting leaves above their host tree. Thus they are major parts of many forest canopies. Yet, relatively little is known about distributions of lianas in tropical forest canopies, because studying those canopies is challenging. This knowledge gap is urgent to address because lianas compete strongly with trees, reduce forest carbon uptake and are thought to be increasing, at least in the Neotropics.
2. Lianas can be difficult to study using traditional field methods. Their pliable stems often twist …