Digital Commons Network^™

Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells In A Mouse Model Of Group 3 Medulloblastoma Implicating Myeloid Cells As Favorable Immunotherapy Targets, Zahra Abbas, Courtney George, Mathew Ancliffe, Meegan Howlett, Anya C. Jones, Mani Kuchibhotla, Robert J. Wechsler-Reya, Nicholas G. Gottardo, Raelene Endersby

Research outputs 2022 to 2026

Medulloblastoma is the most common childhood brain cancer. Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment approaches are crucial for the improvement of clinical outcomes. To date, immunotherapies for medulloblastoma have been unsuccessful, and studies investigating the immune microenvironment of the disease and the impact of current therapies are limited. Preclinical models that recapitulate both the disease and immune environment are essential for understanding immune-tumor interactions and to aid the identification of new and effective immunotherapies. Using an immune-competent mouse model of aggressive Myc-driven medulloblastoma, we characterized the brain immune microenvironment and changes induced …

The Impact Of Radiation Dose To Heart Substructures On Major Coronary Events And Patient Survival After Chemoradiation Therapy For Esophageal Cancer, Xin Wang, Nicolas L Palaskas, Brian P Hobbs, Jun-Ichi Abe, Kevin T Nead, Syed Wamique Yusuf, Joerg Hermann, Anita Deswal, Steven H Lin

Faculty, Staff and Student Publications

Simple Summary

Whether it is necessary to evaluate the radiation exposure of cardiac substructures when making radiotherapy plans is one of the current research hotspots. In this cohort study of 355 patients with esophageal cancer, the radiation dose to key coronary substructures such as the left anterior descending artery V30_Gy and mean left main coronary artery was closely associated with major coronary events and overall patient survival, and showed better predictive value than the mean heart dose or heart V30_Gy recommended by current guidelines. Our findings suggest that, in addition to the whole heart, key coronary substructures should …

Characterization Of Two Novel Toti-Like Viruses Co-Infecting The Atlantic Blue Crab, Callinectes Sapidus, In Its Northern Range Of The United States, Mingli Zhao, Lan Xu, Holly Bowers, Eric J. Schott

Faculty Research, Scholarly, and Creative Activity

The advancement of high throughput sequencing has greatly facilitated the exploration of viruses that infect marine hosts. For example, a number of putative virus genomes belonging to the Totiviridae family have been described in crustacean hosts. However, there has been no characterization of the most newly discovered putative viruses beyond description of their genomes. In this study, two novel double-stranded RNA (dsRNA) virus genomes were discovered in the Atlantic blue crab (Callinectes sapidus) and further investigated. Sequencing of both virus genomes revealed that they each encode RNA dependent RNA polymerase proteins (RdRps) with similarities to toti-like viruses. The viruses were …

Kenyon Collegian - March 3, 2022

The Kenyon Collegian

No abstract provided.

Interview With Jay Chavez About Jay Chavez, Tamara M. Motley

Making History Oral Histories

This interview documents the life and hobbies of UNM student Jay Chavez.

Whither The Lofty Goals Of The Environmental Laws?: Can Statutory Directives Restore Purposivism When We Are All Textualists Now?, Stephen M. Johnson

Pepperdine Law Review

Congress set ambitious goals to protect public health and the environment when it enacted the federal environmental laws through bipartisan efforts in the 1970s. For many years, the federal courts interpreted the environmental laws to carry out those enacted purposes. Over time, however, courts greatly reduced their focus on the environmental and public health purposes of the environmental laws when interpreting those statutes due to the rise in textualism, the declining influence of the Chevron doctrine, and the increasing willingness of courts to defer to agency underenforcement of statutory responsibilities across all regulatory statutes. In 2020, the Environmental Protection Network, …

Civic Engagement As A Pathway To Meaningful Medical Student Engagement On The Social Determinants Of Health, Alexander Reardon, Jennie Deblanc, Alister Martin

Journal of Health Disparities Research and Practice

The social determinants of health have gained increasing prominence in medical education, but medical students and professionals alike are under-prepared to address those determinants. There is a growing body of evidence that voting and other forms of civic engagement affect the health of patients and communities. Registering patients in healthcare settings offers students and professionals an opportunity to impact their patients’ health beyond the clinical encounter. Medical students are particularly well suited to this work for a variety of reasons, including increasingly positive attitudes toward this kind of advocacy, increasing diversity in the medical student body, and lighter clinical and …

Agricultural Producers’ Use Of Genetically Modified Organisms, Michael E. Lawson, Donna A. Hess, Satoko Hirai

Great Plains Sociologist

A random sample of agricultural producers from North and South Dakota, Minnesota, Iowa, and Wisconsin is used to examine producers’ decisions to use or not use genetically modified organisms. Using the rational choice theoretical framework to guide analyses, the associations between proportion of genetically modified corn acres grown by agricultural producers and perceived cost, perceived risk, and perceived benefit. Results indicated that 1) perceived cost was significantly, negatively associated with proportion of GM corn acres planted; 2) perceived risk was significantly, negatively associated with proportion of GM corn acres planted; and 3) perceived benefit was significantly, positively associated with proportion …

Effective Dose Fractionation Schemes Of Radiotherapy For Prostate Cancer, Jose Alvarez, Kathleen M. Storey, Pavitra Kannan, Heyrim Cho

Spora: A Journal of Biomathematics

Radiation therapy remains as one of the main cancer treatment modalities. Typical regimens for radiotherapy comprise a constant dose administered on weekdays, and no radiation on weekends. In this paper, we examine adaptive dosages of radiation treatment strategies for heterogeneous tumors using a dynamical system model that consist of radiation-resistant and parental populations with unique interactive properties, namely, PC3 and DU145 prostate cancer cell lines. We show that stronger doses of radiation given in longer time intervals, while keeping the overall dosage the same, are effective in PC3 cell lines, but not in DU145 cell lines. In addition, we tested …

Conservation Status Assessment Of The Egg-Mimic Darter (Percidae: Etheostoma Pseudovulatum) Using A Multi-Faceted Approach, Zachary L. Wolf, John W. Johansen, Rebecca E. Blanton

Southeastern Fishes Council Proceedings

The imperiled Egg-mimic Darter (Etheostoma pseudovulatum) is a headwater-adapted fish restricted to an area less than 1000 km² in Tennessee. It is found in only six tributaries of the Duck River and the large, mainstem of this system may act as a barrier to dispersal, restricting population connectivity. The only status assessment of this species was over two decades ago; genetic diversity and the degree of population connectivity have never been evaluated. We conducted a conservation status assessment using a multi-faceted approach to better inform conservation management plans, including examining its current distribution, assessing habitat quality, estimating …

How To Hiit While Pregnant? The Protocol Characteristics And Effects Of High Intensity Interval Training Implemented During Pregnancy – A Systematic Review, Anna Szumilewicz, Rita Santos-Rocha, Aneta Worska, Magdalena Piernicka, Hongli Yu, Simona Pajaujiene, Najmeh-Alsadat Shojaeian, Miguel Angel Oviedo-Caro

Baltic Journal of Health and Physical Activity

There is strong scientific evidence that prenatal physical activity of moderate-to-high in-tensity is a prerequisite of the proper course of pregnancy, childbirth and fetus development. How-ever, to date little data have been available on high intensity interval training (HIIT) performed during pregnancy. Following the PRISMA guidelines, this systematic review aimed at: first, to characterize HIIT protocols used or planned to be implemented during pregnancy; second, to determine their training effects on participant’s health and obstetric outcomes. We included nine original works and three clinical trials in the analysis. The HIIT protocols substantially differed in terms of the training components (type, …

Influence Of Using Water Harvesting Techniques On Snake Melon (Cucumis Melo L. Var. Flexuosus) Yield Under Semiarid Conditions, Ayed Ghaleb Salama

Hebron University Research Journal-A (Natural Sciences) - (مجلة جامعة الخليل للبحوث- أ (العلوم الطبيعيه

The majority of cultivated crops in the West Bank are rain-fed; the productivity of these crops is far below its potential. Therefore, the objective of this study is to evaluate the impact of water harvesting techniques (contour ridge and half-moon structure) on snake melon (Cucumis melo L. var. flexuosus) yield under semiarid conditions. Three treatments (contour ridge, half-moon, and control) were evaluated during 2015/2016 and 2017/2018, using randomized complete block design with three replicates. The results showed that the yield of snake melon during a high-rainfall year was about triple (mainly for control treatment) the yield in a low-rainfall year. …

Effect Of Water Stress At Fruit Maturity Stage On Production And Skin Separation Phenomenon Of Date Palm Cv. Medjool, Husameddin Isaid, Alaai Bitar, Hassan Abu-Qaoud

Hebron University Research Journal-A (Natural Sciences) - (مجلة جامعة الخليل للبحوث- أ (العلوم الطبيعيه

Water scarcity and skin separation of the fruits are two major problems in most date palm growing regions in the world. This study aims to evaluate the effect of water stress on date palm productivity and the phenomenon of skin separation in date fruits during the years of 2018 and 2019. The experiment consists of six treatments (S1: 0% water stress as a control, S2: 10% water stress, S3: 20% water stress, S4: 30% water stress, S5: 40% water stress, S6: 50% water stress).The highest significant fruit yield (kg/tree) was recorded in the treatments S1, S2 and S3 during the …

We Are ... Marshall, March 2, 2022, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

A Rulebook For Peptide Control Of Legume–Microbe Endosymbioses, Sonali Roy, Lena Maria Müller

Agricultural and Environmental Sciences Faculty Research

Plants engage in mutually beneficial relationships with microbes, such as arbuscular mycorrhizal fungi or nitrogen-fixing rhizobia, for optimized nutrient acquisition. In return, the microbial symbionts receive photosynthetic carbon from the plant. Both symbioses are regulated by the plant nutrient status, indicating the existence of signaling pathways that allow the host to fine-tune its interactions with the beneficial microbes depending on its nutrient requirements. Peptide hormones coordinate a plethora of developmental and physiological processes and, recently, various peptide families have gained special attention as systemic and local regulators of plant–microbe interactions and nutrient homeostasis. In this review, we identify five 'rules' …

Evergreen Session Five Clean Transcript, Oscar Gonzalez

Heritage Conversation Partners

No abstract provided.

Cwu Faculty Senate Minutes 3/02/22, Janet Shields

Faculty Senate Minutes

These are the official Central Washington University Faculty Senate minutes for the March 2, 2022, regular meeting.

Wildlife Tracking Nrs 432, Michael Cerbo

Collection Development Reports and Documents

No abstract provided.

Wildlife Tracking Nrs 432x, Michael Cerbo

Collection Development Reports and Documents

No abstract provided.

The Anti-Inflammatory Agent Bindarit Attenuates The Impairment Of Neural Development Through Suppression Of Microglial Activation In A Neonatal Hydrocephalus Mouse Model, Eri Iwasawa, Farrah N. Brown, Crystal Shula, Fatima Kahn, Sang Hoon Lee, Temugin Berta, David R. Ladle, Kenneth Campbell, Francesco T. Mangano, June Goto

Neuroscience, Cell Biology & Physiology Faculty Publications

Neonatal hydrocephalus presents with various degrees of neuroinflammation and long-term neurologic deficits in surgically treated patients, provoking a need for additional medical treatment. We previously reported elevated neuroinflammation and severe periventricular white matter damage in the progressive hydrocephalus (prh) mutant which contains a point mutation in the Ccdc39 gene, causing loss of cilia-mediated unidirectional CSF flow. In this study, we identified cortical neuropil maturation defects such as impaired excitatory synapse maturation and loss of homeostatic microglia, and swimming locomotor defects in early postnatal prh mutant mice. Strikingly, systemic application of the anti-inflammatory small molecule bindarit significantly supports healthy …

Spatial And Temporal Patterns Of Fire On Saipan, Cnmi, Ilan E. Bubb, Zachary B. Williams

Marine & Environmental Sciences Faculty Articles

Sediment core studies from Saipan suggest that fires did not play a prominent role in the disturbance regime of the Mariana Islands and have increased in frequency since human settlement around 4,000 years ago. On Saipan fires are understood to interrupt the pattern of succession leading to the degradation of native limestone forests, the proliferation of grasslands and the eventual creation of badlands. Little baseline data regarding the spatial and temporal patterns of fire on Saipan exist to create effective Fire Management Plans. This project uses Landsat 8 images from April 2013 to July 2020 and the Normalized Burn Ratio …

Opposite Trends Of Glycosides And Alkaloids In Dendrobium Nobile Of Different Age Based On Uplc-Q/Tof-Ms Combined With Multivariate Statistical Analyses., An-Jing Lu, Yuan Jiang, Jia Wu, Dao-Peng Tan, Lin Qin, Yan-Liu Lu, Yong Qian, Chao-Jun Bai, Ji-Yong Yang, Hua Ling, Jing-Shan Shi, Zhou Yang, Yu-Qi He

PCOM Scholarly Works

INTRODUCTION: Alkaloids and glycosides are the active ingredients of the herb Dendrobium nobile, which is used in traditional Chinese medicine. The pharmacological effects of alkaloids include neuroprotective effects and regulatory effects on glucose and lipid metabolism, while glycosides improve the immune system. The pharmacological activities of the above chemical components are significantly different. In practice, the stems of 3-year-old D. nobile are usually used as the main source of Dendrobii Caulis. However, it has not been reported whether this harvesting time is appropriate.

OBJECTIVE: The aim of this study was to compare the chemical characteristics of D. nobile in different …

The Relationships Among Job Satisfaction, Length Of Employment, And Mentoring Of Nursing Faculty, Zelda Suzan

Dissertations

The shortage of faculty in nursing education programs has been well documented by the National League for Nursing. Job satisfaction is important in retaining nurse educators, and one New York nursing program was interested in examining the potential impact of mentoring on satisfaction. The purpose of this quantitative study was to examine job satisfaction, measured by the Job Descriptive Index/Job in General scale (JDI/JIG), between nurse faculty participants in formal mentoring programs compared to participants receiving an informal type of mentoring. In addition, the length of employment was examined as a possible factor in predicting job satisfaction. The theoretical framework …

Abood, Richard Oral History Interview, Jeri Bigbee

Emeriti Society Oral History Collection

Professor of Pharmacy Practice (1991-2015). Topics include: Arrival at University of the Pacific, curriculum/programs, people, controversial issues, significant achievements, students, progress/evolution, and the community.

Daily Eastern News: March 02, 2022, Eastern Illinois University

March

No abstract provided.

One Size Does Not Fit All: Implicit Theories Of Body Weight And Body Mass Index Interact To Predict Body Image Disturbances, Kathryn Bruchmann, Chan L. Thai, Brianna Wingard

Psychology

Implicit theories of body weight (ITBW) have predicted successful weight loss efforts, such that incremental beliefs (body weight is malleable) lead to more success and resilience in the face of setbacks than entity beliefs (body weight is unchangeable). But, less is known about how ITBW is related to body image. Two studies tested how ITBW (measured in Study 1, manipulated in Study 2) interacts with body mass index (BMI) to predict body shame, body surveillance, and disordered eating in undergraduate samples (Study 1 N = 296, Study 2 N = 363). We saw evidence that for participants with higher BMIs, …

March 2, 2022 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Task-Based Functional Connectivity And Blood-Oxygen-Level-Dependent Activation During Within-Scanner Performance Of Lumbopelvic Motor Tasks: A Functional Magnetic Resonance Imaging Study, Mark K. Jordon, Jill Campbell Stewart Pt,Phd, Sheri P. Silfies, Paul F. Beattie

Faculty Publications

There are a limited number of neuroimaging investigations into motor control of the lumbopelvic musculature. Most investigation examining motor control of the lumbopelvic musculature utilize transcranial magnetic stimulation (TMS) and focus primarily on the motor cortex. This has resulted in a dearth of knowledge as it relates to how other regions of the brain activate during lumbopelvic movement. Additionally, task-based functional connectivity during lumbopelvic movements has not been well elucidated. Therefore, we used functional magnetic resonance imaging (fMRI) to examine brain activation and ROI-to-ROI task-based functional connectivity in 19 healthy individuals (12 female, age 29.8 ± 4.5 years) during the …

Nanoscale Hybrid Electrolytes With Viscosity Controlled Using Ionic Stimulus For Electrochemical Energy Conversion And Storage, Sara T. Hamilton, Tony G. Feric, Sahana Bhattacharyya, Nelly M. Cantillo, Steven G. Greenbaum, Thomas A. Zawodzinski, Ah-Hyung Alissa Park

Publications and Research

As renewable energy is rapidly integrated into the grid, the challenge has become storing intermittent renewable electricity. Technologies including flow batteries and CO 2 conversion to dense energy carriers are promising storage options for renewable electricity. To achieve this technological advancement, the development of next generation electrolyte materials that can increase the energy density of flow batteries and combine CO 2 capture and conversion is desired. Liquid-like nanoparticle organic hybrid materials (NOHMs) composed of an inorganic core with a tethered polymeric canopy (e.g., polyetheramine (HPE)) have a capability to bind chemical species of interest including CO 2 and redox-active species. …

Chancellor's Cabinet Updates 2022-03, Karen Carey

Chancellor's Cabinet Updates

No abstract provided.