Digital Commons Network^™

The Difference Between Grade 7 Female And Male Test Scores Based On One-To-One Technology Access: A Causal-Comparative Study, Windy Simonne Hammond

Doctoral Dissertations and Projects

This causal-comparative study sought to determine whether there was a relationship between the use of one-to-one technology and student achievement among female and male students in Grades 6 and 7 in public schools in South Carolina. This study adds to the body of literature that indicates academic gains occur from using one-to-one devices in classrooms and that these didactic technology tools are beneficial to all students. The current study analyzed the science and social studies achievement scores of 3,747 Grade 7 students, comparing females and males who had access to one-to-one technology to those who did not during the 2016–2017 …

Sabbath-Keeping And Mental Health: The Influence Of Weekly Sabbath-Keeping On Stress, Anxiety And Well-Being, Kathryn Mcnichol

Doctoral Dissertations and Projects

The purpose of the current study is to explore the effectiveness of a psychoeducational Sabbath intervention. Using a multiple baseline design, subsets of participants were assigned the psychoeducational intervention at varying times and completed a series of mental health questionnaires before, during, and after the intervention to assess its benefits. After receiving the psychoeducational intervention, participants began a weekly Sabbath-keeping practice. This study added to the limited existing literature on Sabbath-keeping and health, specifically mental health, by assessing the impact on anxiety, stress, and well-being. Results of this study indicated a potential connection between the practice of Sabbath-keeping and positive …

Rural Teachers’ And School Leaders’ Perceptions Of School Climate And Student Achievement In Math And Reading: A Multiple Case Study, Matthew James Dolegowski

Doctoral Dissertations and Projects

The purpose of this multiple case study was to investigate teachers’ and school leaders’ perceptions of how school climate affects student achievement in math and reading at rural schools. The conceptual framework guiding this study was Bronfenbrenner’s (1979) ecological systems theory intertwined with the U.S. Department of Education’s School Climate Surveys (EDSCLS) (2019) school climate model to influence student academic achievement. Purposeful criterion sampling was used to select 13 teachers and school leaders from two rural schools in Western New York. Data was collected through a survey, teacher interviews, and school leader interviews. The data was triangulated and analyzed using …

Mentorship Relationships: A Phenomenological Study Investigating Experiences Of Secondary Teachers, Jodi Lee Wilson

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to investigate teachers’ experiences in their mentoring relationships. This study investigated the experiences of 12 secondary teachers with varying levels of teaching experience from the Camel County School District in northeastern Wyoming. Kram’s (1983) original mentorship model guided this study, along with social network theory. The focus of this inquiry was to explore how teachers experience the initiation and cultivation phase of the mentorship relationship within their schools, and how these mentorship relationships positively affect the teachers involved. Data collection methods included interviews, participant-written essays, and focus group sessions to answer the …

Understanding The Quality Of Life Of Parents Whose Young Adult Children Diagnosed With Asperger's Syndrome Live In A College Residential Setting: A Phenomenological Study, Faye Mcravion

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand, as a lived experience, the parents’ quality of life (QoL) with young adult children diagnosed with autism spectrum disorder (ASD) residing on a college campus. In addition, this study helped understand parent experiences related to factors about transition and their QoL. For parents of adult children with ASD in a college residency setting, many stressful and challenging times were attributed to their child living outside the home, which ultimately impacted parental stress and the parents’ QoL. The theory guiding this study is the Schlossberg Transition Theory (1981), and the 4 …

Alaskan Rural Pastors' Lived Experiences With Mental Health Stigma, Josephine Kay Barry

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the lived experiences of rural Alaskan pastors with mental health and mental health stigma both personally and professionally. While there were few studies available to assist with the framework of this research there were some that focused on pastors, depression, burnout and collaboration with counselors in rural areas. A Conceptual Mapping Task (CMT) was used to conduct the interview of five pastors within an isolated Alaskan community. Pastors were asked to describe in detail their lived encounters with mental health stigma and how it impacted them and their congregation. Interviews were …

The Relationship Between Leader-Member Exchange And Citizen Willingness To Comply With Governmental Public Health Mandates Concerning Covid-19 In Dougherty County, Georgia: A Mixed Methods Analysis, Travis H. Goodson

Doctoral Dissertations and Projects

As of February 8, 2022, more than 394,381,395 individuals across the globe have contracted COVID-19; and from this number, reportedly more than 5,735,179 have died due to the virus (World Health Organization, 2022). Amid the COVID-19 pandemic, local, state, and federal governments have fielded a host of public health mandates in an attempt to curtail the spread of the virus; however, little is known about the efficacy of such mandates and how willing compliance is obtained through perceived high-quality leader-member exchanges. Compliance is best defined as willing conformity to official requirements; here, compliance is examined through the lens of relational …

Association Of Prenatal Exposure To Early-Life Adversity With Neonatal Brain Volumes At Birth, Regina L Triplett, Rachel E Lean, Amisha Parikh, J Philip Miller, Dimitrios Alexopoulos, Sydney Kaplan, Dominique Meyer, Christopher Adamson, Tara A Smyser, Cynthia E Rogers, Deanna M Barch, Barbara Warner, Joan L Luby, Christopher D Smyser

2020-Current year OA Pubs

Importance: Exposure to early-life adversity alters the structural development of key brain regions underlying neurodevelopmental impairments. The association between prenatal exposure to adversity and brain structure at birth remains poorly understood.

Objective: To examine whether prenatal exposure to maternal social disadvantage and psychosocial stress is associated with neonatal global and regional brain volumes and cortical folding.

Design, Setting, and Participants: This prospective, longitudinal cohort study included 399 mother-infant dyads of sociodemographically diverse mothers recruited in the first or early second trimester of pregnancy and their infants, who underwent brain magnetic resonance imaging in the first weeks of life. Mothers were …

Oxygen Targets During Mechanical Ventilation In The Icu: A Systematic Review And Meta-Analysis, Andrew F. Cumpstey, Alex H. Oldman, Daniel S. Martin, Andrew Smith, Michael P.W. Grocott

Peninsula Medical School

OBJECTIVES: Patients admitted to intensive care often require treatment with invasive mechanical ventilation and high concentrations of oxygen. Mechanical ventilation can cause acute lung injury that may be exacerbated by oxygen therapy. Uncertainty remains about which oxygen therapy targets result in the best clinical outcomes for these patients. This review aims to determine whether higher or lower oxygenation targets are beneficial for mechanically ventilated adult patients.DATA SOURCES: Excerpta Medica dataBASE, Medical Literature Analysis and Retrieval System Online, and Cochrane medical databases were searched from inception through to February 28, 2021.STUDY SELECTION: Randomized controlled trials comparing higher and lower oxygen targets …

Pulpotomy For Treatment Of Complicated Crown Fractures In Permanent Teeth: A Systematic Review, A Donnelly, F Foschi, P Mccabe, Hf Duncan

Peninsula Dental School

BackgroundConsensus on the treatment of choice for complicated crown fractures of teeth is limited. Recent guidance recommends vital-pulp-therapy; however, the preferred type is not specified. Higher success rates for pulpotomy compared to pulp-capping have been documented, which suggests pulpotomy may be a preferable option for complicated crown-fractures.ObjectivesThe purpose of this systematic review was to determine the success rate of pulpotomy (partial and complete) on teeth that suffered complicated crown fractures. Participants: patients who have suffered a complicated crown fracture to an anterior permanent tooth. Intervention: pulpotomy (partial or complete). Comparator: pulp-capping or root canal treatment. Outcome: combined clinical and radiographic …

The Ethics Of Space Exploration: Harrowing Stories Of Death, Survival, And The Unknown, Roy Balleste

Connecticut Journal of International Law

The desire to conquer space is irresistible. Most frontiers on Earth have been reached, and eventually, there will be no more terrestrial mysteries to solve. Yet, outer space is still there-reminding and tempting us to pursue that journey of discovery. We are presently in a new age of exploration. When humanity entered outer space for the first time, the Cold War was raging and only two nations enjoyed access to the secrets beyond our atmosphere. Now, a new age of commercialization is propelling humanity's entry into space. Once again nations are returning to this vast frontier. Beyond the United States …

Transgender Rural Communities And Legal Rights To Gender-Affirming Health Care, Nathan R. Hamons, Valarie K. Blake

West Virginia Law Review

No abstract provided.

Mms Observations Of The Kelvin-Helmholtz Instability And Associated Ion Scale Waves, Rachel C. Rice

Doctoral Dissertations and Master's Theses

The detailed mechanisms coupling the solar wind to Earth's magnetosphere are not yet fully understood. Solar wind plasma is heated non-adiabatically as it penetrates the magnetosphere, and this process must span scale sizes. Reconnection alone is not able to account for the observed heating; other mechanisms must be at work. One potential process is the Kelvin-Helmholtz instability (KHI). The KHI is a convective instability which operates at the fluid scale in plasmas, but is capable of driving secondary process at smaller scales. Previous work has shown evidence of magnetic reconnection, various ion scale wave modes, mode conversion, and turbulence associated …

The Pathogenesis Of Diabetes And Its Negative Impact On The Retina: Diabetic Retinopathy, Jonathan Nelson

Senior Honors Theses

Diabetic retinopathy causes the plurality of blindness among the working class of America. This review focuses on the biochemistry and pathophysiology of the pancreatic cells during the development of diabetes as well as the effects that diabetes has on the Müller cells and pericytes of the retina at the cellular and molecular levels. In addition, the current research on some of the treatment options for diabetic retinopathy will be presented. This review is valuable to the scientific community because it presents a side-by-side summary of the pathogenesis of diabetes and diabetic retinopathy based on the current body of research.

The Traveling Salesman Problem: An Analysis And Comparison Of Metaheuristics And Algorithms, Mason Helmick

Senior Honors Theses

One of the most investigated topics in operations research is the Traveling Salesman Problem (TSP) and the algorithms that can be used to solve it. Despite its relatively simple formulation, its computational difficulty keeps it and potential solution methods at the forefront of current research. This paper defines and analyzes numerous proposed solutions to the TSP in order to facilitate understanding of the problem. Additionally, the efficiencies of different heuristics are studied and compared to the aforementioned algorithms’ accuracy, as a quick algorithm is often formulated at the expense of an exact solution.

The Role Of Mtorc1 In Autophagy As It Relates To Cancer, Olivia Robinson

Senior Honors Theses

The mammalian target of rapamycin complex 1, mTORC1, is composed of several subunit proteins with many cellular responsibilities including participation in a complex cell signaling cascade leading to autophagy, which is the regulated degradation of cell components. mTORC1 is frequently mutated or dysregulated within human cancer. Normally, mTORC1 functions to provide efficient regulation of autophagy according to intracellular levels of growth factors, amino acids, nutrients, oxygen levels, and more that can either inhibit mTORC1 and upregulate autophagy or activate mTORC1 and downregulate autophagy. A better understanding of mTORC1 is imperative to preparing cancer therapy treatments. Various cancerous tissue types require …

Determining The Genomic Localization And Binding Partners Of Zinc Finger Protein 410, Mariko Locke

Senior Honors Theses

The results of a folate deficiency study affecting cognition in mice suggested the altered genes may be controlled by a transcription factor known as Zinc Finger Protein 410 (Zfp410). Due to a lack of literature on Zfp410’s interacting proteins and DNA-binding location, our study aims to further elucidate the role Zfp410 plays in affecting cognition. A custom antibody was used to determine the Zfp410 isoforms present in mouse and rat brains. Moreover, the antibody was used to determine the binding partners of Zfp410 in the brain and locate specific genomic regions/sequences with which it associates in vivo. These results may …

Sars-Cov-2 Reveals That Chimeric Agents Are The Bioweapons Of The Future, Rachel Craig

Senior Honors Theses

Bioweapons programs have existed since their development during the Cold War. These biowarfare programs initially utilized naturally occurring pathogens capable of infecting crops, livestock populations, and human populations. Anthrax is a widely exploited bioagent responsible for attacks ranging from the Germans’ deployment in World War I to the mailing of anthrax through the postal service in attempts on U.S. senators’ lives. With the development of genetic manipulations, the Soviet Union began modifying anthrax to resist detection and treatment. With the continued advancement of science and technology, a new bioagent has entered the scene – the man-made chimeric virus. Chimeric viruses …

Intentional Male Allies/Advocates: How Male Leaders Can Successfully Champion Female Ministers In The Assemblies Of God U.S.A., Saehee H. Duran

Doctor of Ministry (DMin)

While the Assemblies of God (AG) endorses women in ministry through its position paper and bylaws, a dichotomy has existed between its egalitarian theology and practice since its inception in 1914. One key to narrowing such a gap involves intentional and countercultural male leaders who actively train, empower, affirm, and mentor women called to ministerial leadership. This research defines biblical egalitarian leadership, identifies exemplary female leaders and their male champions in the Old and New Testaments, and explores the best practices of male allyship for female leaders through a literature review and a qualitative survey of active AG male allies …

18 Fdg Pet/Ct Imaging In Carcinoma Cesophagus, Maseeh Uz Zaman, Nosheen Fatima

Department of Radiology

No abstract provided.

Colonic Epithelial Angiotensin-Converting Enzyme 2 (Ace2) Expression In Blacks And Whites: Potential Implications For Pathogenesis Covid-19 Racial Disparities, Deepika Subramanyan, Caroline Zaworski, Priya Roy, Hemant K Roy

Faculty, Staff and Students Publications

BACKGROUND: Covid-19 toll is disproportionate in Blacks although the mechanisms remain incompletely understood. From a biological perspective, several host proteins have received most attention as logical susceptibility targets. Specifically, angiotensin-converting enzyme 2 (ACE2) serves as the epithelial cell receptor and acts in concert with transmembrane protease serine 2 (TMPRSS2). Intriguingly, ACE2 can also suppress the inflammatory response and therefore may impact the severity of Covid-19 infections (from the exuberant immune response a.k.a. "cytokine storm"). We, therefore, assessed expression of ACE2 and TMPRSS2 in Blacks versus Whites.

METHODS: Archived mucosal biopsies from colonoscopic biopsies of visually normal rectal mucosa without concurrent …

Applying The Vulnerability Stress Adaptation Model To Romantic Relationships Of Couples Raising A Child With Asd, Hillary Katherine Schiltz

Dissertations (1934 -)

Cross-sectional evidence indicates that raising a child with autism spectrum disorder (ASD) is associated with strain on caregivers’ romantic couple relationship, yet many couple relationships thrive (Hock et al., 2012; Markoulakis et al., 2012). Research on general population samples highlights changes in couple romantic relationships across short and longer periods of time (e.g., Karney & Bradbury, 1997); little is known, however, about how the relationships of couples raising a child with ASD unfold and which couples are at greater risk for deterioration than others. According to the Vulnerability Stress Adaptation (VSA) Model, couple romantic relationships are directly shaped by how …

Identification Of An Optimal Dose Of Intravenous Ketamine For Late-Life Treatment-Resistant Depression: A Bayesian Adaptive Randomization Trial, Charles E Green, Tabish Iqbal, Lee C Chang, Colin N Haile, Lorna C Hirsch, Nithya Ramakrishnan, Dylan A Fall, Alan C Swann, Rayan K Al Jurdi, Sanjay J Mathew

Faculty, Staff and Students Publications

Evidence supporting specific therapies for late-life treatment-resistant depression (LL-TRD) is necessary. This study used Bayesian adaptive randomization to determine the optimal dose for the probability of treatment response (≥50% improvement from baseline on the Montgomery-Åsberg Depression Rating Scale) 7 days after a 40 min intravenous (IV) infusion of ketamine 0.1 mg/kg (KET 0.1), 0.25 mg/kg (KET 0.25), or 0.5 mg/kg (KET 0.5), compared to midazolam 0.03 mg/kg (MID) as an active placebo. The goal of this study was to identify the best dose to carry forward into a larger clinical trial. Response durability at day 28, safety and tolerability, and …

Conditional Risk For Ptsd Traumatically Injured Latinx Sample: Cultural X Biological Model, Claire Maria Bird

Dissertations (1934 -)

Posttraumatic stress disorder (PTSD) is a debilitating disorder that develops in some people following a traumatic event. Latinx communities in the U.S. are at greater risk of developing this disorder and experiencing more severe and chronic symptomology. This population has also been found to experience greater levels of dissociative experiences – possibly explaining the increased conditional risk for PTSD in this ethnic group. It remains unclear what may be connecting the experience of peritraumatic dissociation to heightened PTSD risk. The current study sought to address this gap in the literature by examining peritraumatic dissociation and the interplay between sociocultural and …

Eeg During Motor Tasks In Stroke: The Effects Of Remote Ischemic Conditioning And Fatigue On Brain Activity, Priya Balasubramanian

Dissertations (1934 -)

This dissertation aimed to use electroencephalography (EEG) to identify the effects of fatigue and remote ischemic conditioning on brain activity. Lesions due to stroke directly or indirectly affect regions of the brain and the descending corticospinal pathways. Cortical reorganization and alternate descending neural pathways are used during recovery from stroke as compensation mechanisms for motor deficits. These mechanisms exacerbate the deficits by worsening the ability to terminate muscle activity, individuate muscles for fine motor control and minimize abnormal muscle synergy and coactivation patterns to conserve resources during movement. Even though imaging and muscle activation studies have documented the existence and …

Ap Physics Course Enrollments: The Impact Of Middle School Algebra And Physics First, Judi G. Luepke

Dissertations (1934 -)

The position of the United States in the global STEM economy is being challenged by other countries. There is national concern that the STEM pipeline be strengthened to ensure more students pursue STEM degrees and join the STEM workforce. Although it is important to inspire youth in STEM programs, it is also important to provide all students access to the STEM gatekeeper courses of calculus, chemistry, and physics. This study determined if taking algebra in middle school and Physics First impacted AP Physics enrollments in a suburban high school. Taking physics in ninth grade, or Physics First, is part of …

Impact Of Corrosion Inhibitors And Metals On Antibiotic Resistance In Drinking Water Distribution Systems, Lee Kimbell

Dissertations (1934 -)

Drinking water distribution systems are important for transporting clean drinking water. Antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in drinking water may pose risks to human and environmental health. Aging infrastructure such as metal pipes can experience significant corrosion, which can have impacts on the chemical and microbial water quality inside of drinking water systems. Chemicals are commonly added to drinking water to prevent corrosion (i.e., corrosion inhibitors). The metal pipe materials and corrosion inhibitors containing metals may have impacts on the bacteria and ARGs in drinking water systems. This research investigated the presence of ARGs in real-world …

Investigating Beliefs & Attitudes Regarding Equitable Teaching & Discipline Practices: Race Essentialism In Schools, Jamee S. Carroll

Dissertations (1934 -)

Black, Latinx, and Indigenous adolescents experience more suspensions, expulsions, and school-based arrests than White students. However, minoritized students do not engage in problematic or disruptive behaviors more frequently but rather at equal or lower rates than their White counterparts. One factor that may contribute to this discipline gap is race essentialism, which is the belief that there are deep-rooted, unalterable traits and abilities unique to each racial group. Race essentialism, which has been linked to stereotyping, prejudice, intergroup trust and closeness, and cognitive flexibility, has not been studied in a school discipline context. Demonstrating associations between race essentialism and teachers’ …

Retinal Organoids Derived From Rhesus Macaque Ipscs Undergo Accelerated Differentiation Compared To Human Stem Cells, Jeffrey Rogers, J Timothy Stout, Sara M Thomasy, Anna La Torre, Rui Chen, Ala Moshiri

Faculty, Staff and Students Publications

PURPOSE: To compare the timing and efficiency of the development of Macaca mulatta, a nonhuman primate (NHP), induced pluripotent stem cell (rhiPSC) derived retinal organoids to those derived from human embryonic stem cells (hESCs).

RESULTS: Generation of retinal organoids was achieved from both human and several NHP pluripotent stem cell lines. All rhiPSC lines resulted in retinal differentiation with the formation of optic vesicle-like structures similar to what has been observed in hESC retinal organoids. NHP retinal organoids had laminated structure and were composed of mature retinal cell types including cone and rod photoreceptors. Single-cell RNA sequencing was conducted at …

Evaluation Of Shoulder Complex Kinematics Pre And Post Rotator Cuff Repair And Effects Of Altering Rotation Sequence, Alyssa Joy Schnorenberg

Dissertations (1934 -)

Approximately 25% of adults in the United States will sustain a rotator cuff tear in their lifetime. Rotator cuff tears can impede one's ability to perform activities of daily living and maintain functional independence. Nearly 300,000 rotator cuff repair surgeries are performed annually and aim to decrease pain, increase range of motion, and enable return to the workforce.The goal of postoperative rehabilitation is to allow healing of the repaired cuff while restoring function and range of motion, but it is demanding and may require a year. However, most rehabilitation protocols are based solely on clinical experience rather than on evidence-based …