Digital Commons Network^™

Microstructural Imaging And Transcriptomics Of The Basal Forebrain In First-Episode Psychosis, Min Tae M. Park, Peter Jeon, Leon French, Kara Dempster, M. Mallar Chakravarty, Michael Mackinley, Julie Richard, Ali R. Khan, Jean Théberge, Lena Palaniyappan

Neuroscience Institute Publications

Cholinergic dysfunction has been implicated in the pathophysiology of psychosis and psychiatric disorders such as schizophrenia, depression, and bipolar disorder. The basal forebrain (BF) cholinergic nuclei, defined as cholinergic cell groups Ch1-3 and Ch4 (Nucleus Basalis of Meynert; NBM), provide extensive cholinergic projections to the rest of the brain. Here, we examined microstructural neuroimaging measures of the cholinergic nuclei in patients with untreated psychosis (~31 weeks of psychosis, <2 defined daily dose of antipsychotics) and used magnetic resonance spectroscopy (MRS) and transcriptomic data to support our findings. We used a cytoarchitectonic atlas of the BF to map the nuclei and obtained measures of myelin (quantitative T1, or qT1 as myelin surrogate) and microstructure (axial diffusion; AxD). In a clinical sample (n = 85; 29 healthy controls, 56 first-episode psychosis), we found significant correlations between qT1 of Ch1-3, left NBM and MRS-based dorsal anterior cingulate choline in healthy controls while this relationship was disrupted in FEP (p > 0.05). Case-control differences in qT1 and AxD were observed in the Ch1-3, with increased qT1 (reflecting reduced myelin content) and AxD (reflecting reduced axonal integrity). We found clinical correlates between left NBM …

Whole-Brain Modelling Identifies Distinct But Convergent Paths To Unconsciousness In Anaesthesia And Disorders Of Consciousness, Andrea I. Luppi, Pedro A.M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard, Guy B. Williams, Michael M. Craig, Paola Finoia, Alexander R.D. Peattie, Peter Coppola, Adrian M. Owen, Lorina Naci, David K. Menon, Daniel Bor, Emmanuel A. Stamatakis

Neuroscience Institute Publications

The human brain entertains rich spatiotemporal dynamics, which are drastically reconfigured when consciousness is lost due to anaesthesia or disorders of consciousness (DOC). Here, we sought to identify the neurobiological mechanisms that explain how transient pharmacological intervention and chronic neuroanatomical injury can lead to common reconfigurations of neural activity. We developed and systematically perturbed a neurobiologically realistic model of whole-brain haemodynamic signals. By incorporating PET data about the cortical distribution of GABA receptors, our computational model reveals a key role of spatially-specific local inhibition for reproducing the functional MRI activity observed during anaesthesia with the GABA-ergic agent propofol. Additionally, incorporating …

Frontoparietal Connectivity As A Product Of Convergent Evolution In Rodents And Primates: Functional Connectivity Topologies In Grey Squirrels, Rats, And Marmosets, David J. Schaeffer, Kyle M. Gilbert, Miranda Bellyou, Afonso C. Silva, Stefan Everling

Neuroscience Institute Publications

Robust frontoparietal connectivity is a defining feature of primate cortical organization. Whether mammals outside the primate order, such as rodents, possess similar frontoparietal functional connectivity organization is a controversial topic. Previous work has primarily focused on comparing mice and rats to primates. However, as these rodents are nocturnal and terrestrial, they rely much less on visual input than primates. Here, we investigated the functional cortical organization of grey squirrels which are diurnal and arboreal, thereby better resembling primate ecology. We used ultra-high field resting-state fMRI data to compute and compare the functional connectivity patterns of frontal regions in grey squirrels …

Cognitive Composites For Genetic Frontotemporal Dementia: Genfi-Cog, Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma Van Der Ende, Esther Van Den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre De Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard

Neuroscience Institute Publications

Background: Clinical endpoints for upcoming therapeutic trials in frontotemporal dementia (FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but are lacking in genetic FTD. We aimed to create cognitive composite scores for genetic frontotemporal dementia (FTD) as well as recommendations for recruitment and duration in clinical trial design. Methods: A standardized neuropsychological test battery covering six cognitive domains was completed by 69 C9orf72, 41 GRN, and 28 MAPT mutation carriers with CDR® plus NACC-FTLD ≥ 0.5 and 275 controls. Logistic regression was used to identify the combination of tests that distinguished best between each mutation carrier …

Serologic Surveillance For Sars-Cov-2 Infection Among Wild Rodents, Europe, Vincent Bourret, Lara Dutra, Hussein Alburkat, Sanna Mäki, Ella Lintunen, Marine Wasniewski, Ravi Kant, Maciej Grzybek, Vinaya Venkat, Hayder Asad, Julien Pradel, Marie Bouilloud, Herwig Leirs, Valeria Carolina Colombo, Vincent Sluydts, Peter Stuart, Andrew Mcmanus, Jana A. Eccard, Jasmin Firozpoor, Christian Imholt, Joanna Nowicka, Aleksander Goll, Nathan Ranc, Guillaume Castel, Nathalie Charbonnel, Tarja Sironen

Publications

We report results from serologic surveillance for exposure to SARS-CoV-2 among 1,237 wild rodents and small mammals across Europe. All samples were negative, with the possible exception of 1. Despite suspected potential for human-to-rodent spillover, no evidence of widespread SARS-CoV-2 circulation in rodent populations has been reported to date.

Esitämme tulokset serologisesta tutkimuksesta, jossa seulottiin SARS-CoV-2 tartuntojen varalta 1,237 luonnonvaraista jyrsijää ja piennisäkästä eri puolilta Eurooppaa. Kaikki näytteet olivat negatiivisia, yhtä näytettä lukuun ottamatta. SARS-CoV-2:n läikkymisen ihmisistä jyrsijöihin on arveltu olevan mahdollista, mutta todisteet viruksen laajamittaisesta leviämisestä jyrsijäpopulaatioissa puuttuvat.

Blind Spot: Implicit Bias In Health Care And Its Awareness Among Nursing Students At The University Of Southern Mississippi, Debora Skaliks

Doctoral Projects

While prejudice and bias are eminent topics in our society, implicit bias or unconscious bias is not as easily detected. Even though implicit bias may be a familiar concept to many, numerous healthcare workers frequently do not recognize the extent of harm such biases can impose on patients' health and outcomes. The Blind Spot DNP project exposed in this research paper explores the relentless question of the correlation between implicit bias awareness, implicit bias education, and its impact on health care. This Doctor of Nursing Project (DNP) project aimed to analyze whether implicit bias education and testing could increase unconscious …

An Ultrasensitive Bacterial Detection Platform For Culture-Free Diagnosis Of Infections, Xuyang Shi

ETD Archive

The current methods of the diagnosis of bloodstream infections are based on bacterial culture growth, a process that requires considerable time, e.g., 12-16 hours, to obtain a result. This long wait time for the result creates many problems, including the generation of multi-drug resistant organisms (MDROs). At the same time, infected bloodstream usually contains a very low concentration of bacteria, i.e., lower than 5 CFU/mL. The long diagnosis time and the extremely low concentration of bacteria in the infected bloodstream make such infections difficult to diagnose. Here, we demonstrate a culture-free approach for the diagnosis of bloodstream infections using a …

Text And Image Frames Affect Message's Sharing And Acceptance Of Social Media Users, Xin Sa

ETD Archive

No abstract provided.

Lipids Affect The Diffusion Of Estradiol In Osteonal Bone, Nicholas Anthony Cimino

ETD Archive

In healthy osteonal bone, embedded osteocytes form an intercellular communication network through overlapping cell membrane extensions, possibly defining an overlooked and clinically relevant lipid-mediated transport pathway for nonpolar molecules. Previous techniques evaluating solute transport in cortical bone limit tissue analysis to microscale areas (less than 1 mm2) using tracers and assumptions that diminish clinical relevance, presenting the need for an improved method to evaluate solute diffusion in macroscale areas (greater than 1 mm2) of osteonal bone. A new diffusion system - constructed of glass and polytetrafluoroethylene - was designed and validated for this purpose, exhibiting minimal adsorption of solutes and …

Musmorph, A Database Of Standardized Mouse Morphology Data For Morphometric Meta-Analyses, Jay Devine, Marta Vidal-García, Wei Liu, Amanda Neves, Lucas D. Lo Vercio, Rebecca M. Green, Heather A. Richbourg, Marta Marchini, Colton M. Unger, Audrey C. Nickle, Bethany Radford, Nathan M. Young, Paula N. Gonzalez, Robert E. Schuler, Alejandro Bugacov, Campbell Rolian, Christopher J. Percival, Trevor Williams, Lee Niswander, Anne L. Calof, Arthur D. Lander, Axel Visel, Frank R. Jirik

Biology: Faculty Publications and Other Works

Complex morphological traits are the product of many genes with transient or lasting developmental effects that interact in anatomical context. Mouse models are a key resource for disentangling such effects, because they offer myriad tools for manipulating the genome in a controlled environment. Unfortunately, phenotypic data are often obtained using laboratory-specific protocols, resulting in self-contained datasets that are difficult to relate to one another for larger scale analyses. To enable meta-analyses of morphological variation, particularly in the craniofacial complex and brain, we created MusMorph, a database of standardized mouse morphology data spanning numerous genotypes and developmental stages, including E10.5, E11.5, …

Sleep To Reduce Incident Depression Effectively (Stride): Study Protocol For A Randomized Controlled Trial Comparing Stepped-Care Cognitive-Behavioral Therapy For Insomnia Versus Sleep Education Control To Prevent Major Depression, Christopher L. Drake, David A. Kalmbach, Philip Cheng, Brian K. Ahmedani, Edward L. Peterson, Christine L. M. Joseph, Thomas Roth, Kelley M. Kidwell, Chaewon Sagong

Sleep Medicine Articles

BACKGROUND: Prevention of major depressive disorder (MDD) is a public health priority. Strategies targeting individuals at elevated risk for MDD may guide effective preventive care. Insomnia is a reliable precursor to depression, preceding half of all incident and relapse cases. Thus, insomnia may serve as a useful entry point for preventing MDD. Cognitive-behavioral therapy for insomnia (CBT-I) is recommended as the first-line treatment for insomnia, but widespread implementation is limited by a shortage of trained specialists. Innovative stepped-care approaches rooted in primary care can increase access to CBT-I and reduce rates of MDD.

METHODS/DESIGN: We propose a large-scale stepped-care clinical …

Geographic Distribution: Anolis Sagrei (Brown Anole). Usa: Arizona., Addie Leimroth, Louis A. Somma, Dyrana N. Russell, Logan P. Cutts, Mason Ryan, Randall D. Babb, Karen E. Hajek, Andrew T. Holycross

Papers in Herpetology

We discovered the first distributional records for the exotic, Caribbean lizard, Anolis sagrei (Brown Anole), in Arizona.

Interdisciplinary Design Studio: Programming Document Visioning For A Robotic Demonstration, Research, And Engagement Dairy, Steve(N) Hardy, Nate Bicak, Sarah Alduaylij, Noor Al-Maamari, Devyn Beekman, Kelsey Belgum, Lauren Chubb, Nicholas Forte, Mitchell Hill, Joshua Holstein, Dylan Lambe, Phuong Le, Mia Leriger, Elizabeth Loftus, Josh Lorenzen, Megan Lovci, Alex Martino, Zade Miller, Hannah Morgan, Annabelle Nichols, Collin Shearman, Rebecca Sowl, Nalin Theplikhith, Angela Vu, Shaylee Wagner, Ethan Watermeier, Trever Zelenka

Architecture Program: Student Creative Activity

The 2022 COLLABORATE Design Studio brought together students from various disciplines to address a complex, real-world project which required collaborative input from different perspectives. The studio worked to advance the co-creation of knowledge between external stakeholders, students, and instructors. The course was co-taught by faculty from different disciplines, and areas of expertise. During the semester, Nate Bicak and Steven Hardy worked with students from Architecture and Interior Design in collaboration with students in Dr. Tami Brown-Brandl’s students in Biological Systems Engineering and Animal Science to explore the values, spatial qualities, and area requirements of a Robotic Demonstration, Research, and Engagement …

Biology, Monitoring, Sampling, And Management Of Rice Billbug, Sphenophorus Pertinax, In Furrow-Irrigated Rice, Chase Alan Floyd

Graduate Theses and Dissertations

Furrow-irrigated rice hectares have increased annually for the last five years in the predominant long-grain rice producing states. Initial implementation of the system began in the 1980’s, but lack of rice blast (Magnaporthe grisea, Hebert) resistant cultivars made the system a nonviable option for rice producers. Hybridization of rice cultivars with less susceptibility has begun to increase the interest of producers to implement a furrow-irrigated rice production system due to the cost saving opportunities that it may provide. Elimination of the flood from large sections of the rice fields in a furrow-irrigated system alters management strategies and pest complexes compared …

Evaluation Of Biological And Chemical Seed Treatments For Management Of Rice Diseases, Sherif Adam Sharfadine

Graduate Theses and Dissertations

Rice is the primary staple for more than half of the global population and is the second most important cereal worldwide. In the US, rice is primarily grown in the southern states, with Arkansas leading production and responsible for 47% of the total rice production in the country. Diseases cause significant yield losses in rice. Sheath blight, rice blast and bacterial panicle blight are the main diseases in rice and cause significant yield losses. Sheath blight alone could cause up 50% yield loss in heavily damaged fields with highly susceptible cultivars. Additionally, rice seed and seedling diseases primarily caused by …

Flood Hazard And Risk Analyses In The Republic Of Panama: A Case Study From The Juan Diaz River Watershed In Panama City, Virgilio De Jesus Quintero

Graduate Theses and Dissertations

Flooding is the natural hazard with most occurrences in Panama. Its frequency and magnitude have increased over the years. This dissertation analyzes Panama’s flood activity in order to better understand flood hazards, the current evolution of Panamanian perceptions of flood risk, and the incorporation of indigenous knowledge used to mitigate flood hazards. The first chapter developed a baseline of past and current flood inventory in Panama, which required the use of flood historical data, thematic cartography, and Geographic Information Science (GIS). This chapter shows Panama has experienced floods in varying degrees. Through the spatial and temporal distribution of floods from …

Evaluation Of Chrysodeixis Includens Nucleopolyhedrovirus (Chinnpv) Formulations For Soybean Looper (Chrysodeixis Includens) Control In Soybean, Caleb Robert Rice

Graduate Theses and Dissertations

Chrysodeixis includens Nucleopolyhedrovirus (ChinNPV) specifically Chrysogen, has been commercially available in South America since 2016 but is not current available in the U.S. Chrysogen targets soybean looper (Chrysodeixis includens) (SBL), the major defoliator of soybean (Glycine max (L.) Merrill) in the mid-southern region of the U.S. Experiments were conducted during the 2020 and 2021 growing seasons to evaluate effectiveness of three formulations of Chrysogen at multiple rates for control of SBL. Soybean looper larvae used for following experiments were kept in an insect incubator at the University of Arkansas Lonoke Research and Extension Center. The first objective was to evaluate …

Alkaline Nucleoplasm Facilitates Contractile Gene Expression In The Mammalian Heart, Alzbeta Hulikova, Kyung Chan Park, Aminah A. Loonat, Mala Gunadasa-Rohling, M. Kate Curtis, Yu Jin Chung, Abigail Wilson, Carolyn A. Carr, Andrew W. Trafford, Marjorie Fournier, Anna Moshnikova, Oleg A. Andreev, Yana K. Reshetnyak, Paul R. Riley, Nicola Smart, Thomas A. Milne, Nicholas T. Crump, Pawel Swietach

Physics Faculty Publications

Cardiac contractile strength is recognised as being highly pH-sensitive, but less is known about the influence of pH on cardiac gene expression, which may become relevant in response to changes in myocardial metabolism or vascularization during development or disease. We sought evidence for pH-responsive cardiac genes, and a physiological context for this form of transcriptional regulation. pHLIP, a peptide-based reporter of acidity, revealed a non-uniform pH landscape in early-postnatal myocardium, dissipating in later life. pH-responsive differentially expressed genes (pH-DEGs) were identified by transcriptomics of neonatal cardiomyocytes cultured over a range of pH. Enrichment analysis indicated “striated muscle contraction” as a …

How Disgust In Germ Averse Individuals Biases Avoidance Decision-Making, Wesley Stuart, Timothy Schoenfeld Phd

Science University Research Symposium (SURS)

The present study investigates the relationship between germ aversion and avoidant decision making. Individuals in the general population who rate highly in germ-aversion and disgust sensitivity may act maladaptively in order to avoid potentially anxiety inducing scenarios. If encountered, these scenarios will cause an increase in physiological arousal and a suppression of salivatory cortisol in the individual. We hypothesize that this stress response biases decision making in an avoidant manner. Participants for this study, consisting of 60 undergraduate students at Belmont University, started by taking a perceived vulnerability to disease scale. Then, those in the experimental group performed a task …

Clemson Commencement Program, December 2022, Clemson University

Clemson Commencement Programs

No abstract provided.

(R2022) Mathematical Modelling Of Tuberculosis And Covid-19 Co-Infection In India: A Real Data Analysis On Concomitant Diseases, Vijai Shanker Verma, Harshita Kaushik, Archana Singh Bhadauria

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we have proposed an epidemiological model to study the dynamics of two concomitant diseases Tuberculosis (TB) and COVID-19. Here, we have formulated a deterministic compartmental model as an extended form of the classical SIS model. First, the basic reproduction number R₀ is derived and then stability analysis of the model is done. It is observed that the disease-free equilibrium is stable when R₀ is less than one and the endemic equilibrium is stable only when R₀ is greater than one. Numerical simulation is carried out to illustrate the theoretical findings and to study the …

Lifespan Benefits For The Combination Of Rapamycin Plus Acarbose And For Captopril In Genetically Heterogeneous Mice., Randy Strong, Richard A Miller, Catherine J Cheng, James F Nelson, Jonathan Gelfond, Shailaja Kesaraju Allani, Vivian Diaz, Angela Olsen Dorigatti, Jonathan Dorigatti, Elizabeth Fernandez, Andrzej Galecki, Brett Ginsburg, Karyn L Hamilton, Martin A Javors, Kerry Kornfeld, Matt Kaeberlein, Suja Kumar, David B Lombard, Marisa Lopez-Cruzan, Benjamin F Miller, Peter Rabinovitch, Peter C. Reifsnyder, Nadia Rosenthal, Molly A. Bogue, Adam B Salmon, Yousin Suh, Eric Verdin, Herbert Weissbach, John Newman, Francesca Maccchiarini, David E. Harrison

Faculty Research 2022

Mice bred in 2017 and entered into the C2017 cohort were tested for possible lifespan benefits of (R/S)-1,3-butanediol (BD), captopril (Capt), leucine (Leu), the Nrf2-activating botanical mixture PB125, sulindac, syringaresinol, or the combination of rapamycin and acarbose started at 9 or 16 months of age (RaAc9, RaAc16). In male mice, the combination of Rapa and Aca started at 9 months and led to a longer lifespan than in either of the two prior cohorts of mice treated with Rapa only, suggesting that this drug combination was more potent than either of its components used alone. In females, lifespan in mice …

Wics Conference 2022: Water And Integrated Cropping Systems: Driving Research, Teaching, And Extension Impact --Slide Presentation, Wics Conference

Water and Integrated Cropping Systems Conferences

What conference attendees had to say:

"The teaching overview and panel discussion provided many insights on how education pathways are evolving and the need to create diverse opportunities to meet dynamic needs."

"The extension component was valuable in seeing how those doing research can collaborate with and assist extension educators to make a greater impact in the state."

"It was good to learn what relevant research is being conducted and also the work being done in teaching in regards to water and cropping systems."

It was a great first WICS Conference. The discussions have only just begun.

Occurrence Of Bat Species At Water Sources In Two Urban Parks In Nashville, Tennessee, Maya Kiev, Austin Farris, Evan Mason

Science University Research Symposium (SURS)

Animal behavioral patterns can shift due to anthropogenic factors related to pollution, human impact on flora/fauna, and changes in local water sources. While sound pollution can impact the occurrence of bats in urban areas, other factors could also influence bat behavior. This study examines bat occurrence near a water source at two urban parks in Nashville, Tennessee: one is in a highly trafficked area while the other is secluded and bordered by a suburban neighborhood. Both parks have small ponds, numerous trees, and open green spaces. Echo Meter Touch 2 devices were used to capture bat echolocation data at each …

What’S For Breakfast? An Analysis Of American Breakfast Food Advertisements And The Promotion Of Binge Eating Disorder Behaviors, Debbie Danowski

Communication, Media & The Arts Faculty Publications

“They’re great!!” an animated Tiger named Tony shouts as both children and adults cheer about the introduction of a new cereal that is chocolate frosted. Later in the 15-second commercial, children are encouraged to “LET YOUR GR-R-REAT OUT” with wording that appears above an image of a father and son eating cereal together seated closely on a sofa. This ad, which first aired on January 1, 2018 and stopped airing on October 1, 2018 received over 4 billion TV impressions of which more than 3.8 billion were shown nationally. And, as most of those watching were unaware, it also included …

The Development Of A Novel Peptide-Drug Conjugate For Treating Triple-Negative Breast Cancer, Phi-Phung Than

Pharmaceutical Sciences (MS) Theses

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognosis and is difficult to treat. A diagnosis of TNBC means that the three most common types of receptors known to fuel most breast cancer growth–estrogen, progesterone, and HER2– are not present in the cancer tumors. Since the tumor cells lack necessary receptors, common treatments like hormone therapies and targeted HER2 drugs are ineffective. The use of chemotherapies in treating TNBC is an effective option instead. However, chemotherapies are not selective, thus they cause severe side effects such as cardiotoxicity, myelosuppression, alopecia and gastrointestinal problems. A peptide-drug conjugate …

News From Hope College, Volume 54.2: Winter, 2022, Hope College

News from Hope College

No abstract provided.

A Single Centre Experience Of Local Perforator Flaps In Oncoplastic Breast Surgery: A Cross-Sectional Study, Sana Zeeshan, Lubna Vohra, Uzma Shamsi, Nida Zahid, Danish Ali, Nargis Asad, Cristina Garusi

Section of General Surgery

Background & objectives: Various oncoplastic techniques have emerged over the years to preserve breast cosmesis and symmetry without compromising the principles of tumor excision. One of the newer techniques for breast volume replacement to achieve symmetry and cosmesis is the use of fasciocutaneous pedicled chest wall perforator flaps or local perforator flaps (LPF). The objectives of this study were to document the details of the surgical procedure as well as patient-reported satisfaction and well-being following the procedure using a validated BREAST-Q tool among Pakistani women.
Materials & methods: This cross-sectional study was conducted from March 2019 to February 2021 enrolling …

(R1522) Modelling The Influence Of Desertic Aerosols On The Transmission Dynamics Of Neisseria Meningitidis Serogroup A, Francis Signing, Berge Tsanou, Samuel Bowong

Applications and Applied Mathematics: An International Journal (AAM)

This paper assesses the role of desert aerosols and vaccine on the transmission dynamics of Neisseria Meningitis serogroup A (NmA). It is biologically well-documented that the inhalation of aerosol dust and its presence in the nasal cavity weakens the nasopharyngeal mucosa by damaging the mucosal barrier and inhibiting the mucosal immune defenses of susceptible and vaccinated individuals. We address the latter by proposing and analyzing a mathematical model for the dynamics of NmA that specifically accounts for the fast progression of susceptible and vaccinated individuals to the invasive stage of the disease. We compute the basic reproduction number and use …

Environmental Influences On The Growth Of Inland Cisco Populations In Three Minnesota Sentinel Lakes, Edward Carlson

Biology Graduate Theses

Cisco Coregonus artedi are a pelagic cold-water fish that are widely distributed throughout many inland lakes across the northern Midwest and play an important role as forage for large piscivores. Inland Cisco populations have been observed to vary in their overall size and recruitment potential based on the system in which they are found. Cisco are sensitive to oxythermal stress and with climate change, land use, and invasive species effects becoming more prevalent in Minnesota, aspects of lake ecosystems are changing, ultimately making Cisco more susceptible to these stressors. To investigate how different factors were affecting the population dynamics of …