Digital Commons Network^™

Winners Announced For 10th Annual Nh Social Venture Innovation Challenge, Sustainability Institute

Sustainability Institute Blog

No abstract provided.

A Theoretical And Performer’S Analysis Of Todd Goodman’S Tuba Concerto And Extended Program Notes Of Recital Pieces, Johnathan De Soto Jr.

Electronic Theses & Dissertations

This document analyzes American composer Todd Goodman's 2012 work for solo tuba titled Tuba Concerto. It contains 10 chapters, including one for each of the three movements of the work: an introduction providing biographical information on the composer and context for the work within the late twentieth century and early twenty-first century; a performer’s analysis on the solo tuba part; and the biographical and performance information of composers also performed on the accompanying recital. Each of the four chapters includes theoretical analyses regarding each of Goodman's movements and practical considerations for performers of the work to observe. The thesis also …

Program: Echoes Through Time, University Of Dayton

Dance and Theater Programs

Music by Caitlyn Hood

Dec. 2, 2022

Boll Theatre in Kennedy Union

Co-produced by the Theatre, Dance, and Performance Technology program and the Department of Music

We embarked on the Echoes Through Time journey with the intention to allow the student ensemble to learn about the life of Paul Laurence Dunbar through the creation of an original theatre performance with music selections. This show was devised from the students’ exploration of his life and legacy and the incorporation of music that put poetry to song. As directors, we were particularly taken with how the women in Dunbar’s life were compelling …

Biomarker, Treatment, And Socio-Demographic Factors Affecting Opioid Use Disorder Treatment Retention, Fernand A. De Los Reyes

Dissertations

Increasing mortality from opioid overdose and low treatment engagement are significant public health concerns. Along with increasing health care and criminal justice enforcement costs, there is an urgent need to study the factors associated with treatment retention in opioid use disorder. The study investigated the relative impact of the biomarker cholesterol on treatment retention in an opioid treatment program (OTP) clinic. Further, it examined the medical comorbidities, treatment, and socio-demographic variables that impact opioid use disorder treatment retention. This study was a secondary analysis of patient health records (n=267) in an opioid treatment program clinic. The study employed a hierarchical …

Georgia Southern University Fact Book, Georgia Southern University

Georgia Southern Fact Books (1976-2022)

No abstract provided.

Pollination Ecology Of Island Endemic Plants: A Case Study On The California Channel Islands, C. Sheena Sidhu, Giselle E. Lozano, Michelle C. Miner, Emily Howe, Erin E. Wilson-Rankin

Western North American Naturalist

Understanding the pollination requirements of threatened species is critical for the success of long-term conservation strategies. In a series of greenhouse experiments, we assessed the effects of different pollination treatments, including autogamy, facilitated autogamy, and cross-pollination on fruit and seed set for 2 generations of a rare island endemic plant. Santa Cruz Island rockcress, Sibara filifolia (Brassicaceae), is a rare, endangered annual herb that is endemic to the California Channel Islands. While efforts are underway to monitor and conserve this rare plant species, little is known about its pollination biology. We quantified the index of self-compatibility and multiplicative fitness. We …

Treatment Of Epilepsy Using A Targeted P38Γ Kinase Gene Therapy, Nicolle Morey, Magdalena Przybyla, Julia Van Der Hoven, Yazi D Ke, Fabien Delerue, Janet Van Eersel, Lars M Ittner

Faculty, Staff and Student Publications

Hyperphosphorylated microtubule-associated protein tau has been implicated in dementia, epilepsy, and other neurological disorders. In contrast, site-specific phosphorylation of tau at threonine 205 (T205) by the kinase p38γ was shown to disengage tau from toxic pathways, serving a neuroprotective function in Alzheimer's disease. Using a viral-mediated gene delivery approach in different mouse models of epilepsy, we show that p38γ activity-enhancing treatment reduces seizure susceptibility, restores neuronal firing patterns, reduces behavioral deficits, and ameliorates epilepsy-induced deaths. Furthermore, we show that p38γ-mediated phosphorylation of tau at T205 is essential for this protection in epilepsy, as a lack of this critical interaction reinstates …

Utilization Of Gis In Tracking Disinterment And Movement Of Unknown Us Wwii War Dead: Foundations For A Geospatial Approach To Addressing Commingled Remains, Ella Axelrod

Department of Anthropology: Theses and Student Research

In the aftermath of World War II, the US was faced with the monumental task of finding and identifying over 405,000 service members who did not survive the conflict (McDermott, 2005, p. 1). Of these 405,000, 81,000 remain missing and 2,498 remain unidentified in cemeteries across Europe alone (American Battle Monuments Commission, 2022). Often, these individuals were interred and disinterred multiple times, crossing the continent in the journey from loss incident or battlefield to their final resting place. Commingling, the accidental mixing of remains, is an ever-present concern in the forensic identification of individuals from mass casualty incidents (Belcher et …

Improving Adjacency List Storage Methods For Polypeptide Similarity Analysis, Arianna Swensen

Honors Theses

Protein design is a complex biomolecular and computational problem. Working on increasingly large protein folding problems requires an improvement in current analysis methods available. This work first discusses various methods of protein design, including de novo protein design, which is the primary focus of this thesis. Then, a new approach utilizing a B+ tree to effectively store and query a graph of keys and vertices is proposed in order to store the number of times two polypeptides are considered to be similar. This approach is found to have a reduction in time complexity from current mapping methods and thus provides …

Sustained Aurora Kinase B Expression Confers Resistance To Pi3k Inhibition In Head And Neck Squamous Cell Carcinoma, Pooja A Shah, Vaishnavi Sambandam, Anne M Fernandez, Hongyun Zhao, Tuhina Mazumdar, Li Shen, Qi Wang, Kazi M Ahmed, Soma Ghosh, Mitchell J Frederick, Jing Wang, Faye M Johnson

Faculty, Staff and Student Publications

UNLABELLED: Tumor suppressor mutations in head and neck squamous cell carcinoma (HNSCC) dominate the genomic landscape, hindering the development of effective targeted therapies. Truncating and missense mutations in NOTCH1 are frequent in HNSCC, and inhibition of PI3K can selectively target NOTCH1 mutant (NOTCH1MUT) HNSCC cells. In this study, we identify several proteins that are differentially regulated in HNSCC cells after PI3K inhibition based on NOTCH1MUT status. Expression of Aurora kinase B (Aurora B), AKT, and PDK1 following PI3K inhibition was significantly lower in NOTCH1MUT cell lines than in wild-type NOTCH1 (NOTCH1WT) cells or NOTCH1MUT cells with acquired resistance to PI3K …

Active Dna Demethylation Promotes Cell Fate Specification And The Dna Damage Response, Dongpeng Wang, Wei Wu, Elsa Callen, Raphael Pavani, Nicholas Zolnerowich, Srikanth Kodali, Dali Zong, Nancy Wong, Santiago Noriega, William J Nathan, Gabriel Matos-Rodrigues, Raj Chari, Michael J Kruhlak, Ferenc Livak, Michael Ward, Keith Caldecott, Bruno Di Stefano, André Nussenzweig

Faculty, Staff and Students Publications

Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source of this endogenous damage remains unclear. Using two systems of postmitotic lineage specification-induced pluripotent stem cell-derived neurons and transdifferentiated macrophages-we show that thymidine DNA glycosylase (TDG)-driven excision of methylcytosines oxidized with ten-eleven translocation enzymes (TET) is a source of SSBs. Although macrophage differentiation favors short-patch base excision repair to fill in single-nucleotide gaps, neurons also frequently use the long-patch subpathway. Disrupting this gap-filling process using anti-neoplastic cytosine analogs triggers a DNA damage response and neuronal cell death, which is dependent on TDG. …

Genome-Edited Zebrafish Model Of Abcc8 Loss-Of-Function Disease, Jennifer M Ikle, Robert C Tryon, Soma S Singareddy, Nathaniel W York, Maria S Remedi, Colin G Nichols

2020-Current year OA Pubs

ATP-sensitive potassium channel (K

Identification Of Novel Antifungal Skeleton Of Hydroxyethyl Naphthalimides With Synergistic Potential For Chemical And Dynamic Treatments, Pengli Zhang, Vijai Kumar Reddy Tangadanchu, Chenghe Zhou

2020-Current year OA Pubs

The invasion of pathogenic fungi poses nonnegligible threats to the human health and agricultural industry. This work exploited a family of hydroxyethyl naphthalimides as novel antifungal species with synergistic potential of chemical and dynamic treatment to combat the fungal resistance. These prepared naphthalimides showed better antifungal potency than fluconazole towards some tested fungi including

Sitting Time And Insulin Resistance In 6,931 United States Adults: The Role Of Abdominal Adiposity, Kayla Marie Parker

Theses and Dissertations

This cross-sectional investigation of 6,931 U.S. adults examined the relationship between sitting time and insulin resistance. A primary objective was to evaluate how this relationship was mediated by the following variables: age, sex, race, year of assessment, cigarette smoking, physical activity, body mass index (BMI), and waist circumference. Self-reported sitting time, measured in minutes per day, was the exposure variable. Insulin resistance, indexed by the homeostatic model assessment of insulin resistance (HOMA-IR), was the outcome variable. Data were used from the 2011-2018 National Health and Nutrition Examination Survey (NHANES). Results showed a strong, positive association between sitting time and insulin …

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output In Dnmt3a-Mutant Clonal Hematopoiesis, Jennifer M Sanmiguel, Elizabeth Eudy, Matthew A Loberg, Kira A Young, Jayna J Mistry, Kristina D Mujica, Logan S Schwartz, Timothy M Stearns, Grant A Challen, Jennifer J Trowbridge

2020-Current year OA Pubs

UNLABELLED: Clonal hematopoiesis resulting from the enhanced fitness of mutant hematopoietic stem cells (HSC) associates with both favorable and unfavorable health outcomes related to the types of mature mutant blood cells produced, but how this lineage output is regulated is unclear. Using a mouse model of a clonal hematopoiesis-associated mutation, DNMT3AR882/+ (Dnmt3aR878H/+), we found that aging-induced TNFα signaling promoted the selective advantage of mutant HSCs and stimulated the production of mutant B lymphoid cells. The genetic loss of the TNFα receptor TNFR1 ablated the selective advantage of mutant HSCs without altering their lineage output, whereas the loss of TNFR2 resulted …

Recent Technical Breakthroughs Enable Smart Manufacturing: A Review, Manish Kumar, Shanu Pandey, Kanchan Upadhyay, Pritibala Taunk, Raunak Kumar Tamrakar

Al-Bahir

In human culture, machine learning has long been used to address complicated issues. Machine learning is successful because of the help provided by computational power and sensing technology. Data-driven strategies and the development of artificial intelligence will soon have a significant impact on the industry. Common examples include search engines, picture recognition, biometrics, speech and handwriting recognition, natural language processing, as well as medical diagnostics and credit scores. It is obvious that when artificial intelligence permeates our globe and, more precisely, our lives, numerous challenges will become public. According to predictions, Industry 4.0 or Smart Manufacturing will be the next …

Gc-308 Heart Disease Prediction And Analysis By Machine Learning, Venkata Sabarinath Nekkalapu, Venkata Anusha Yammada, Mrinal Kapoor, Sai Sindhu Ponugoti, Suman Pudota

C-Day Computing Showcase

The heart is the most crucial part of the Human body. The organ circulates blood out of the circulatory system’s blood vessels. Any disease or failure of this organ causes death. Heart disease is one of the primary sources of death in the cutting-edge world. There are 2,380 deaths from heart disease each day, based on 2018 data. Also, heart disease causes the highest number of deaths globally, with approximately 18 million people dying yearly, meaning around 31This prediction can be made using Machine Learning techniques. With machine learning. Combining a prediction model with machine learning correctly classified results for …

Ur-285 Operation Enduring Freedom: Improving Mission Effectiveness By Identifying Trends In Successful Terrorism, Dalton A. Shaver

C-Day Computing Showcase

This research examines how the characteristics of terrorist attacks predict the chance of an attack succeeding, where an attack is defined as successful if the intended attack type is carried out. Data was analyzed across three geographical missions within Operation Enduring Freedom: Trans-Sahara, Horn of Africa, and the Philippines. Using predicted probabilities of success obtained from logistic regression models, the medians were plotted to compare the characteristics of terrorist attacks across missions. By determining the specific features of attacks that produce the highest probabilities of success, the effectiveness of Operation Enduring Freedom can be improved by focusing counter-terrorism training and …

Vol. 48 No. 9 - Whole No. 350, Jason Fisher

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 48 No. 8 - Whole No. 349, Jason Fisher

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 48 No. 4 - Whole No. 345, Jason Fisher

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Feedback As Boundary Object: Intersections Of Writing, Response, And Research, Lindsey Harding, Joshua King, Anya Bonanno, Joseph Powell

Journal of Response to Writing

While a great deal is known about instructor response to student writing—from commenting practices to student perceptions—less is known about how feedback impacts students’ writing and writerly development. While we set out to study students’ explicit engagement with written instructor feedback, our initial experimental design was disrupted by the COVID-19 pandemic. Accordingly, we describe the dialogic collaborative process that emerged as we considered both the data we were able to collect and, in turn, feedback anew. This article proposes that feedback on student writing is a boundary object which affords those interacting with it the opportunity for collaboration despite the …

Esp For Biotechnology Purposes In Serbian Higher Education: The Skills Required And Blended Learning Environment, Milevica Bojovic

Global Advances in Business Communication

Biotechnology engineering is a complex domain that explores the use of living systems and organisms to develop products or any technological application that uses biological systems and living organisms to make or modify products or processes for specific use in the production of raw food, feed, and food processing. English as a foreign language in biotechnology engineering reflects the complexity in terms of content knowledge, language skills, and strategies characteristic of biotechnology. The article focuses on the knowledge and skills a biotechnology engineer should acquire with the emphasis on communicative language ability in English as a foreign language for specific …

Vol. 47 No. 3 - Whole No. 332, Jason Fisher

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

2021/2022 Robert E. Kennedy Library Annual Report, Robert E. Kennedy Library

Library Publications and Administrative Reports

This year’s stories highlight successes and transformations, which will remain woven into the fabric of our organization. Instituting contactless pick-up for library materials is an example of learning how to quickly bring together people to solve immediate problems. We also became more effective at engaging with our constituencies. We reached more users through virtual consultations and online reference assistance and helped them get access to the expertise and materials they needed. We opened access to special collections through on-demand digitization. We broke barriers in the adoption of digital resources for teaching. And we began the challenging work of developing a …

Pacific Magazine 2022, University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

Weighted Devices For Somatosensory Regulation, Bri Swain, Kaelyn Obryan, Lauren Magat, Nik Gargiulo, Hailey Houck

Occupational Therapy Student Research

Description: A weighted vest is a vest that typically has 10% of a person’s body weight evenly distributed around the vest (Olson et al., 2004). A weighted vest can provide sensory input that is believed to alleviate dysregulation, inattentiveness, and stereotypic behaviors (Carter et al., 2009).

Goal: Our community group is specifically targeting children with sensory processing impairments who are attending speech therapy sessions at the RiteCare clinic. Sensory behaviors exhibited by the clients are most commonly shown through dysregulation, outbursts, inattentiveness, and hyperactivity. The goal is to limit these maladaptive behaviors and increase attention span during intervention sessions. Weighted …

Vegetation Type Is An Important Predictor Of The Arctic Summer Land Surface Energy Budget, Jacqueline Oehri, Gabriela Schaepman-Strub, Jin Soo Kim, Raleigh Grysko, Heather Kropp, Inge Grünberg, Vitalii Zemlianskii, Oliver Sonnentag, Eugénie S. Euskirchen, Merin Reji Chacko, Giovanni Muscari, Peter D. Blanken, Joshua F. Dean, Alcide Di Sarra, Richard J. Harding, Ireneusz Sobota, Lars Kutzbach, Elena Plekhanova, Aku Riihelä, Julia Boike, Nathaniel B. Miller, Jason Beringer, Efrén López-Blanco, Paul C. Stoy, Ryan C. Sullivan, Marek Kejna, Frans Jan W. Parmentier, John A. Gamon, Mikhail Mastepanov, Christian Wille, Marcin Jackowicz-Korczynski, Dirk N. Karger, William L. Quinton, Jaakko Putkonen, Dirk Van As, Torben R. Christensen, Maria Z. Hakuba, Robert S. Stone, Stefan Metzger, Baptiste Vandecrux

School of Natural Resources: Faculty Publications

Despite the importance of high-latitude surface energy budgets (SEBs) for land-climate interactions in the rapidly changing Arctic, uncertainties in their prediction persist. Here, we harmonize SEB observations across a network of vegetated and glaciated sites at circumpolar scale (1994–2021). Our variance-partitioning analysis identifies vegetation type as an important predictor for SEB-components during Arctic summer (June-August), compared to other SEB-drivers including climate, latitude and permafrost characteristics. Differences among vegetation types can be of similar magnitude as between vegetation and glacier surfaces and are especially high for summer sensible and latent heat fluxes. The timing of SEB-flux summer-regimes (when daily mean values …

Bioenergy Crops As A Promising Alternative To Fossil Fuels In Louisiana: A Geographic Information System (Gis) Perspective, Yaw A. Twumasi, Zhu H. Ning, John B. Namwamba, Abena B. Asare-Ansah, Edmund C. Merem, Harriet B. Yeboah, Judith Oppong, Matilda Anokye, Diana B. Frimpong, Priscilla M. Loh, Julia Atayi, Rechael N.D. Armah, Caroline Y. Apraku, Opeyemi I. Oladigbolu, Cynthia C. Ogbu, Leah W. Njeri, Joyce Mcclendon-Peralta

Faculty Publications

Rising greenhouse gas emissions are causing climate change, and the world’s focus has shifted to the need to reduce our reliance on fossil fuels. There has been a rise in the published literature on the utilization of crops for bioenergy production in Louisiana. However, very few scholarly documents have used Geographic Information Systems (GIS) to map the distribution of potential bioenergy crops in Louisiana. This study seeks to fill the void by evaluating the potential of bioenergy crops in Louisiana for energy production using GIS. Given this objective, the agricultural census data for 1999, 2009, 2019, and 2020 obtained from …

Faculty And Staff Perceptions Of Their Roles In Preparing Students For College And Career Readiness: A Qualitative Exploration Of High Schools, Community Colleges, And Universities, Monica Ruiz

Theses & Dissertations

In 2020, nearly half of Texas’s 385,000 public high school graduates were unprepared for college-level reading or math. Limited research reveals K-12 faculty perceive limited roles and responsibilities in the college process, relying heavily on guidance counselors and college admissions counselors for preparing students for college and careers. The purpose of this study was to help fill this gap by answering the central research question: How do high school and college-level faculty and staff prepare high school students for college and careers? I chose a qualitative, interpretive design to explore educators’ individual and shared social meanings and interpretations. I used …