Digital Commons Network^™

Patterns Of Convergence And Divergence Between Bipolar Disorder Type I And Type Ii: Evidence From Integrative Genomic Analyses, Yunqi Huang, Yunjia Liu, Yulu Wu, Yiguo Tang, Mengting Zhang, Siyi Liu, Liling Xiao, Shiwan Tao, Min Xie, Minhan Dai, Mingli Li, Hongsheng Gui, Qiang Wang

Behavioral Health Articles

Aim: Genome-wide association studies (GWAS) analyses have revealed genetic evidence of bipolar disorder (BD), but little is known about the genetic structure of BD subtypes. We aimed to investigate the genetic overlap and distinction of bipolar type I (BD I) & type II (BD II) by conducting integrative post-GWAS analyses.

Methods: We utilized single nucleotide polymorphism (SNP)-level approaches to uncover correlated and distinct genetic loci. Transcriptome-wide association analyses (TWAS) were then approached to pinpoint functional genes expressed in specific brain tissues and blood. Next, we performed cross-phenotype analysis, including exploring the potential causal associations between two BD subtypes and lithium …

Synergies Of Integrated Pest And Pollinator Management In Avocado Farming In East Africa: An Ex-Ante Economic Analysis, Charity Wangithi, Beatrice W. Muriithi, Gracious Diiro, Thomas Dubois, Samira Mohamed, Michael G. Lattorff, Benignus V. Ngowi, Elfatih M. Abdel-Rahman, Mariam Adan, Menale Kassie

All Peer-Reviewed Publications

Using synthetic pesticides to manage pests can threaten pollination services, affecting the productivity of pollination-dependent crops such as avocado. The need to mitigate this negative externality has led to the emergence of the concept of integrated pest and pollinator management (IPPM) to achieve both pest and pollinator management, leading to complementary or synergistic benefits for yield and quality of the harvest. This paper aims to evaluate the potential economic and welfare impact of IPPM in avocado production systems in Kenya and Tanzania. We utilize both primary and secondary data and employed the economic surplus model. On average the potential economic …

Awareness And Health Promotional Behaviour Regarding Non-Alcoholic Fatty Liver Disease, Tintu Benjamin

Manipal Journal of Nursing and Health Sciences

The study was conducted to assess the awareness and health promotional behaviour regarding non- alcoholic fatty liver disease among female population at risk . Methods: this non- experimental research study was conducted among 149 females under risk of developing Non Alcoholic Fatty Liver Disease. Data collection tools used were a risk assessment checklist, a questionnaire to assess the knowledge and a rating scale to assess the health promotional behaviour. Results: overall awareness regarding Non Alcoholic Fatty Liver Disease among the risk population was average (47.69%).The reported health promotional behaviour regarding Non Alcoholic Fatty Liver Disease was good (67.03%). There is …

Effect Of Daily Tramadol Administration On Sperm Indices And Morphology Of Testes In Rabbits, Mathias A. Emokpae, Oluwakemi Femi-Idris, Blessing Onuyoh-Adaitire

Manipal Journal of Nursing and Health Sciences

Introduction: Tramadol is an effective analgesic used in the treatment of mild to severe pains, but unregulated use may cause deleterious effects on the reproductive system of males. Objective: The objective of this study was to evaluate Method: the effect of graded doses and duration of Tramadol on sperm indices and histomorphology of testes in male rabbits. This is an experimental study of 24 male rabbits, divided into eight groups of three rabbits in each group. The rabbits were administered 10, 15, and 20 mg/kg daily doses of Tramadol intramuscularly for 15 and 30 days while F and G received …

Book Review: Sushmita Pati, Properties Of Rent: Community, Capital And Politics In Globalising Delhi, Aniket Nandan

Articles

Book review: Sushmita Pati, Properties Of Rent: Community, Capital And Politics In Globalising Delhi

Shades Of Life In Indian Abortion Law, Gauri Pillai

Articles

This case comment analyses the recent Kerala High Court decision in Cry of Life Society v Union of India, where a petition was filed to declare India's law on abortion unconstitutional for violating the right to life of the foetus. The High Court dismissed the petition, upholding the constitutionality of the legislation as protecting women's right to life. The author discusses the High Court's order, narrowing in on the right to life argument used by the Court, and the right to life argument that the Court missed. This analysis distills and responds to the 'shades of life' underlying abortion law …

Reduced Range Size And Important Bird And Biodiversity Area Coverage For The Harpy Eagle ( Harpia Harpyja ) Predicted From Multiple Climate Change Scenarios, Luke J. Sutton, David L. Anderson, Miguel Franco, Christopher J.W. Mcclure, Everton B.P. Miranda, F. Hernán Vargas, F. Hernán Vargas, Robert Puschendorf

School of Biological and Marine Sciences

No abstract provided.

Acute Bioenergetic Insulin Sensitivity Of Skeletal Muscle Cells: Atp-Demand-Provoked Glycolysis Contributes To Stimulation Of Atp Supply, R.A. Donnell, J.E. Carré, C. Affourtit

School of Biomedical Sciences

Skeletal muscle takes up glucose in an insulin-sensitive manner and is thus important for the maintenance of blood glucose homeostasis. Insulin resistance during development of type 2 diabetes is associated with decreased ATP synthesis, but the causality of this association is controversial. In this paper, we report real-time oxygen uptake and medium acidification data that we use to quantify acute insulin effects on intracellular ATP supply and ATP demand in rat and human skeletal muscle cells. We demonstrate that insulin increases overall cellular ATP supply by stimulating the rate of glycolytic ATP synthesis. Stimulation is immediate and achieved directly by …

Wetlands As Social Ecological Systems, And Relationality In The Policy Domain, Pierre Horwitz

Research outputs 2022 to 2026

A wetland policy perspective based on social ecological systems accepts that wetlands are part of landwaterscapes, that people are part of wetland ecosystems, and that the health of wetlands and the health of people are interdependent, evidence of the close, reciprocal and indivisible relationships between nature and culture. These relationships are storied and place-based, associated with place attachment, and are representations of relational values. They are most easily located wherever and whenever Indigenous and local peoples’ knowledge and interests are at play in wetland settings. Legal and administrative processes that recognise Chthonic law and rights for wetlands will elevate relational …

Biomarkers Of Nanomaterials Hazard From Multi-Layer Data, V Fortino, Pas Kinaret, M Fratello, A Serra, La Saarimäki, A Gallud, G Gupta, G Vales, M Correia, O Rasool, J Ytterberg, M Monopoli, T Skoog, P Ritchie, S Moya, S Vázquez-Campos, R Handy, R Grafström, L Tran, R Zubarev, R Lahesmaa, K Dawson, K Loeschner, Eh Larsen, F Krombach, H Norppa, J Kere, K Savolainen, H Alenius, B Fadeel, D Greco

School of Biological and Marine Sciences

AbstractThere is an urgent need to apply effective, data-driven approaches to reliably predict engineered nanomaterial (ENM) toxicity. Here we introduce a predictive computational framework based on the molecular and phenotypic effects of a large panel of ENMs across multiple in vitro and in vivo models. Our methodology allows for the grouping of ENMs based on multi-omics approaches combined with robust toxicity tests. Importantly, we identify mRNA-based toxicity markers and extensively replicate them in multiple independent datasets. We find that models based on combinations of omics-derived features and material intrinsic properties display significantly improved predictive accuracy as compared to physicochemical properties …

State: The Magazine Of Illinois State University, Fall 2022, Illinois State University, University Marketing And Communications

State: The Magazine of Illinois State University (1999-present)

Illinois State University alumni magazine

State: The Magazine Of Illinois State University, Summer 2022, Illinois State University, University Marketing And Communications

State: The Magazine of Illinois State University (1999-present)

Illinois State University alumni magazine

The Role Of L-Alanine Signaling In Aspergillus Fumigatus Biofilm Adherence, Carbon Catabolism, And Echinocandin Susceptibility., Joshua D. Kerkaert

Dartmouth College Ph.D Dissertations

Aspergillus fumigatus is a saprophytic filamentous fungus that participates in environmental carbon and nitrogen cycles through the degradation of complex organic substrates. In addition to its ecological role, A. fumigatus is the primary causative agent of a spectrum of diseases depending on the immune status of the individual, the most lethal of which is invasive aspergillosis (IA). Treatment strategies for IA are limited and far too frequently fail. Despite the high rates of treatment failure, antifungal resistance remains relatively low, albeit rising at a concerning rate. Insights into this discrepancy between the rate of treatment failure and the rate of …

Genetic Diversity Of Diaphorina Citri (Hemiptera: Liviidae) Unravels Phylogeographic Structure And Invasion History Of Eastern African Populations, Inusa Jacob Ajene, Fathiya Mbarak Khamis, Barbara Van Asch, Gerhard Pietersen, Nurhussen Seid, Anne Wambui Wairimu, Fidelis Levi Ombura, Komivi Senyo Akutse, Mamoudou Sétamou, Sevgan Subramanian, Samira Mohammed, Sunday Ekesi

All Peer-Reviewed Publications

The Asian citrus psyllid (Diaphorina citri Kuwayama) is a key pest of Citrus sp. worldwide, as it acts as a vector for Candidatus Liberibacter asiaticus, the bacterial pathogen that causes citrus Huanglongbing. Diaphorina citri has been reported in Kenya, Tanzania, and more recently in Ethiopia. This study assessed the genetic diversity and phylogeographic structure of the pest to gain insights into the potential sources of its introduction into Africa. Population structure and differentiation of D. citri populations from China, Ethiopia, Kenya, Tanzania, and the USA were assessed using 10 microsatellite loci. Additionally, five new complete mitogenomes of D. citri collected …

The Impacts Of Climate Change On Blackeye Goby, Rhinogobiops Nicholsii, Stress Responses, Reproduction, And Offspring Fitness, Alora Yarbrough

Capstone Projects and Master's Theses

Along with warming and sea level rise, the increasing intensity of ocean acidification (OA) and hypoxia events in coastal environments is of large concern as climate change progresses. Weakened immune function, altered reproductive output, reduced aerobic scope, and hyperventilation are just some of the ways OA and hypoxia negatively affect fish. Under stress, such as OA or hypoxia, fish will produce the hormone cortisol to maintain homeostasis, so cortisol concentration can be used to determine the relative stress an animal is experiencing. This study evaluated the stress response of adult female blackeye gobies under both acute and chronic exposure to …

Redescription Of Southwestern Indian Ocean Guitarfishes Rhinobatos (Rhinopristiformes: Rhinobatidae), Rachel Aitchison

Capstone Projects and Master's Theses

The shark-like rays (Order Rhinopristiformes) are found worldwide and are among the most threatened species of cartilaginous fishes. The guitarfishes (Family Rhinobatidae) are one of five families in this order, with many species being assessed as vulnerable, endangered, or critically endangered by the International Union for Conservation of Nature (IUCN). Current fisheries and conservation efforts are limited, however, due to unresolved taxonomic issues and poor species descriptions. Presently, there are three described species of Rhinobatos from the Southwestern Indian Ocean: Rhinobatos austini, R. holcorhynchus, and R. nudidorsalis. These three species of Rhinobatos are often mistaken for one …

Uni Schedule Of Classes: Policies And Procedures, Summer 2022, University Of Northern Iowa

UNI Schedule of Classes

A listing and schedule of the courses being taught as well as policies and procedures concerning attending classes at the University of Northern Iowa.

Crosssections, Summer 2022, University Of Northern Iowa. Department Of Physics.

CrossSections

Contents:

A Message from the Department Head, Dr. Paul Shand ---- 1
Faculty Profile - Jeff Morgan ---- 3
Department Happenings ---- 5
Student Profile - Aaron Kirchman ---- 8
Student Focus ---- 10
Physics Education ---- 12
Alumni Profile - Dr. Tyler Rash ---- 14
Alumni News ---- 15
Donor Feature ---- 16
New Physics ---- 18

Analysis Of Neonatal Neurobehavior And Developmental Outcomes Among Preterm Infants., Elisabeth C. Mcgowan, Julie A. Hofheimer, T Michael O'Shea, Howard Kilbride, Brian S. Carter, Jennifer Check, Jennifer Helderman, Charles R. Neal, Steve Pastyrnak, Lynne M. Smith, Marie Camerota, Lynne M. Dansereau, Sheri A. Della Grotta, Barry M. Lester

Manuscripts, Articles, Book Chapters and Other Papers

Importance: The ability to identify poor outcomes and treatable risk factors among very preterm infants remains challenging; improving early risk detection and intervention targets to potentially address developmental and behavioral delays is needed.

Objective: To determine associations between neonatal neurobehavior using the Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale (NNNS), neonatal medical risk, and 2-year outcomes.

Design, Setting, and Participants: This multicenter cohort enrolled infants born at less than 30 weeks' gestation at 9 US university-affiliated NICUs. Enrollment was conducted from April 2014 to June 2016 with 2-year adjusted age follow-up assessment. Data were analyzed from December 2019 to …

Lfa-1 Activation Enriches Tumor-Specific T Cells In A Cold Tumor Model And Synergizes With Ctla-4 Blockade, Amber Hickman, Joost Koetsier, Trevin Kurtanich, Michael C Nielsen, Glenn Winn, Yunfei Wang, Salah-Eddine Bentebibel, Leilei Shi, Simone Punt, Leila Williams, Cara Haymaker, Charles B Chesson, Faisal Fa'ak, Ana L Dominguez, Richard Jones, Isere Kuiatse, Amy R Caivano, Sayadeth Khounlo, Navin D Warier, Upendra Marathi, Robert V Market, Ronald J Biediger, John W Craft, Patrick Hwu, Michael A Davies, Darren G Woodside, Peter Vanderslice, Adi Diab, Willem W Overwijk, Yared Hailemichael

Faculty, Staff and Student Publications

The inability of CD8+ effector T cells (Teffs) to reach tumor cells is an important aspect of tumor resistance to cancer immunotherapy. The recruitment of these cells to the tumor microenvironment (TME) is regulated by integrins, a family of adhesion molecules that are expressed on T cells. Here, we show that 7HP349, a small-molecule activator of lymphocyte function-associated antigen-1 (LFA-1) and very late activation antigen-4 (VLA-4) integrin cell-adhesion receptors, facilitated the preferential localization of tumor-specific T cells to the tumor and improved antitumor response. 7HP349 monotherapy had modest effects on anti-programmed death 1-resistant (anti-PD-1-resistant) tumors, whereas combinatorial treatment with anti-cytotoxic …

Impact Of Venetoclax And Azacitidine In Treatment-Naïve Patients With Acute Myeloid Leukemia And Idh1/2 Mutations, Daniel A Pollyea, Courtney D Dinardo, Martha L Arellano, Arnaud Pigneux, Walter Fiedler, Marina Konopleva, David A Rizzieri, B Douglas Smith, Atsushi Shinagawa, Roberto M Lemoli, Monique Dail, Yinghui Duan, Brenda Chyla, Jalaja Potluri, Catherine L Miller, Hagop M Kantarjian

Faculty, Staff and Student Publications

Purpose: To evaluate efficacy and safety of venetoclax + azacitidine among treatment-naïve patients with IDH1/2-mutant (mut) acute myeloid leukemia (AML).

Patients and methods: Data were pooled from patients enrolled in a phase III study (NCT02993523) that compared patients treated with venetoclax + azacitidine or placebo + azacitidine and a prior phase Ib study (NCT02203773) where patients were treated with venetoclax + azacitidine. Enrolled patients were ineligible for intensive therapy due to age ≥75 years and/or comorbidities. Patients on venetoclax + azacitidine received venetoclax 400 mg orally (days 1-28) and azacitidine (75 mg/m2; days 1-7/28-day cycle).

Results: …

Molecular Characterization And Prospective Evaluation Of Pathologic Response And Outcomes With Neoadjuvant Therapy In Metaplastic Triple-Negative Breast Cancer, Clinton Yam, Nour Abuhadra, Ryan Sun, Beatriz E Adrada, Qing-Qing Ding, Jason B White, Elizabeth E Ravenberg, Alyson R Clayborn, Vicente Valero, Debu Tripathy, Senthilkumar Damodaran, Banu K Arun, Jennifer K Litton, Naoto T Ueno, Rashmi K Murthy, Bora Lim, Luis Baez, Xiaoxian Li, Aman U Buzdar, Gabriel N Hortobagyi, Alistair M Thompson, Elizabeth A Mittendorf, Gaiane M Rauch, Rosalind P Candelaria, Lei Huo, Stacy L Moulder, Jeffrey T Chang

Faculty, Staff and Student Publications

PURPOSE: Metaplastic breast cancer (MpBC) is a rare subtype of breast cancer that is commonly triple-negative and poorly responsive to neoadjuvant therapy in retrospective studies.

EXPERIMENTAL DESIGN: To better define clinical outcomes and correlates of response, we analyzed the rate of pathologic complete response (pCR) to neoadjuvant therapy, survival outcomes, and genomic and transcriptomic profiles of the pretreatment tumors in a prospective clinical trial (NCT02276443). A total of 211 patients with triple-negative breast cancer (TNBC), including 39 with MpBC, received doxorubicin-cyclophosphamide-based neoadjuvant therapy.

RESULTS: Although not meeting the threshold for statistical significance, patients with MpBCs were less likely to experience …

Targeting Syndecan-1: New Opportunities In Cancer Therapy, Zecheng Yang, Shuaitong Chen, Haoqiang Ying, Wantong Yao

Faculty, Staff and Student Publications

Syndecan-1 (SDC1, CD138) is one of the heparan sulfate proteoglycans and is essential for maintaining normal cell morphology, interacting with the extracellular and intracellular protein repertoire, as well as mediating signaling transduction upon environmental stimuli. The critical role of SDC1 in promoting tumorigenesis and metastasis has been increasingly recognized in various cancer types, implying a promising potential of utilizing SDC1 as a novel target for cancer therapy. This review summarizes the current knowledge on SDC1 structure and functions, including its role in tumor biology. We also discuss the highlights and limitations of current SDC1-targeted therapies as well as the obstacles …

Socioeconomic Status And Gastric Cancer Surgical Outcomes: A National Cancer Database Study., Ryan Lamm, D Brock Hewitt, Michael Li, Adam C Powell, Adam C Berger

Department of Surgery Faculty Papers

INTRODUCTION: Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. Surgical resection is the gold standard of treatment. In the United States, race and socioeconomic status are associated with the diagnosis of GC; however, no studies have examined these as independent risk factors for surgical outcomes. Our study sought to investigate socioeconomic factors and GC surgical outcomes using a national cancer registry.

METHODS: GC patients between 2004 and 2016 were identified using the National Cancer Database. Univariate and multivariate logistic regression was used to analyze associations between socioeconomic factors and 30-d mortality, 90-d mortality, and unplanned readmission …

Observing The Distribution Of Mosquito Bites On Humans To Inform Personal Protection Measures Against Malaria And Dengue Vectors, Winifrida P. Mponzi, Johnson K. Swai, Emmanuel W. Kaindoa, Khamis Kifungo, Alvaro E. Eiras, Elis P.A. Batista, Nancy S. Matowo, Peter O. Sangoro, Marceline F. Finda, Arnold S. Mmbando, Tegemeo Gavana, Halfan S. Ngowo, Fredros O. Okumu

All Peer-Reviewed Publications

Background Understanding mosquito biting behaviours is important for designing and evaluating protection methods against nuisance biting and mosquito-borne diseases (e.g. dengue, malaria and zika). We investigated the preferred biting sites by Aedes aegypti and Anopheles arabiensis on adult volunteers in standing or sleeping positions; and estimated the theoretical protection limits affordable from protective clothing or repellent-treated footwear. Methods Adult volunteers dressed in shorts and t-shirts were exposed to infection-free laboratory-reared mosquitoes inside screened chambers from 6am to noon (for day-biting Ae. aegypti) or 6pm to midnight (night-biting An. arabiensis). Attempted bites on different body parts were recorded. Comparative observations were …

A Parallel Infodemic: Multifaceted Approaches To Online Public Health Mis- And Disinformation During The Covid-19 Pandemic, Erin Hutchins

UC Law Journal

During the COVID-19 pandemic, communities congregated in online spaces more than ever before. While some people found solidarity online, many others found snippets of false information regarding COVID-19’s origin, transmission, and preventative measures. Inaccurate public health information originated long before the COVID-19 pandemic, but it thrived as the uncertainty around daily living dragged on. The pandemic prompted a conversation about who, if anyone, is responsible for deciphering and regulating the spread of false and misleading information. This Note presents two methods in which inaccurate information can be redressed. First, Section 230 of the Communications Decency Act—which provides sweeping immunity for …

The Schools, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Undergraduate Academic Regulations, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Biological Hydrogen Gas Production From Food Waste As A Sustainable Fuel For Future Transportation, Pitiporn Asvapathanagul, Leanne Deocampo, Nicholas Banuelos

Mineta Transportation Institute

In the global search for the right alternative energy sources for a more sustainable future, hydrogen production has stood out as a strong contender. Hydrogen gas (H2) is well-known as one of the cleanest and most sustainable energy sources, one that mainly yields only water vapor as a byproduct. Additionally, H2 generates triple the amount of energy compared to hydrocarbon fuels. H2 can be synthesized from several technologies, but currently only 1% of H2 production is generated from biomass. Biological H2 production generated from anaerobic digestion is a fraction of the 1%. This study aims to enhance biological H2 production …

Systematic Literature Review Of Experiences And Supports For Students With Asd Post Hoc: Findings Regarding Diversity And Implications For Research And Educator Preparation, Eric J. Lopez, Mariya T. Davis

Special Education Faculty Publications (Archived)

The following post hoc analysis examines cultural and/or linguistic information from a previous systematic literature review of 24 studies investigating demographic information, encounters, assists and suggestions of study participants enrolled in post-secondary education institutions with autism spectrum disorder (ASD). The analysis and discussion of results appeal for the need to not only include and focus on diversity but to refocus on cultural consciousness. Implications and future directions for research and for educator preparation programs are proposed.