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Hipermetropía, Gabriela Christiansen, Jessica Murray, Olivia Roane, Hayden Webster Dec 2022

Hipermetropía, Gabriela Christiansen, Jessica Murray, Olivia Roane, Hayden Webster

Student Spanish Newspapers Collection

Hipermetropia directly translates into far-sighted which is the focus of our newspaper, we decided to showcase topics on the science, news, and history that affects us now and into the future. In our newspaper, you will find articles about the climate effects of the rain forest, the historical figure of César Chávez, and the events like Día de Los Muertos. We hope you enjoy and are enlightened with a new far-sighted perspective created by our authors, Gabriela Christiansen, Jessica Murray, Olivia Roane, and Hayden Webster.


Faculty Senate Executive Committee Agenda, December 12, 2022, Utah State University Dec 2022

Faculty Senate Executive Committee Agenda, December 12, 2022, Utah State University

Faculty Senate & Faculty Senate Executive Committee

  • Call to Order: Approval of Minutes- Nov 14, 2022
  • University Business
  • Information: Educational Policies Committee
  • Reports: Council on Teacher Education; Scholarship Advisory Board
  • Old Business: Athletic Spending
  • New Business: Divestment Proposal
  • Adjourn


The Bison, December 8, 2022 Dec 2022

The Bison, December 8, 2022

The Bison Newspapers

No abstract provided.


The Effects Of True Crime Media, Zoe Patton Dec 2022

The Effects Of True Crime Media, Zoe Patton

Fall Student Research Symposium 2022

True crime is a media genre of growing popularity, and also of growing controversy. Recent media production has sparked debate over how the genre affects the public's perception on crime, as well as how it affects the victims family. I wanted to discover how true crime media can be a genre that helps the public more than it hurts, and offers information and education rather than romanticization of terrible people and events, and discover all the ways that it can cause harm, so we can learn how to stop and understand the parts that can be harmful. Research was conducted …


Deep-Brain Shape Features Differentially Relate To Social Outcomes In Pediatric Traumatic Brain Injury, Braydon Lee Dec 2022

Deep-Brain Shape Features Differentially Relate To Social Outcomes In Pediatric Traumatic Brain Injury, Braydon Lee

Undergraduate Honors Theses

Pediatric traumatic brain injury (TBI) is a global issue with major health consequences. The integrity of brain structures and their social functional correlates are at risk in children with TBI. In this study, magnetic resonance images of the thalamus, caudate, putamen, and globus pallidus were examined in a pediatric TBI group from the Social Outcomes of Brain Injury in Kids (SOBIK). Shape deformations of these structures were compared to an orthopedically injured (OI) control. Additionally, the correlation between shape deformation and theory of mind (ToM) measures were mapped and compared. This study found inward deformations in the ventral thalamic nuclei …


Integrative Revision Of Five Genera Type Species For Zoanthidea To Bridge The Parataxonomy Gap, Jacob Colbert Dec 2022

Integrative Revision Of Five Genera Type Species For Zoanthidea To Bridge The Parataxonomy Gap, Jacob Colbert

All HCAS Student Capstones, Theses, and Dissertations

Cnidarian order Zoanthidea is a relatively understudied group of invertebrates inhabiting a diverse range of marine habitats. Over/During the last two decades, species descriptions within this order have largely been based on a novel molecular parataxonomic system that relies almost exclusively on DNA barcodes to detect and describe new species. DNA barcodes are short, conserved sequences that are readily compared across taxa and used to detect previously described species. The existing taxonomic system, based on anatomical analysis and the identification of evolutionarily informative characters for phylogenetic inference, has been recently replaced by molecular parataxonomy by some scientists/researchers. While molecular sequence …


Aero Engines Remaining Useful Life Prediction Based On Enhanced Adaptive Guided Differential Evolution, Sara Abdelghafar, Ali Khater, Ali Wagdy, Ashraf Darwish Dec 2022

Aero Engines Remaining Useful Life Prediction Based On Enhanced Adaptive Guided Differential Evolution, Sara Abdelghafar, Ali Khater, Ali Wagdy, Ashraf Darwish

Faculty Journal Articles

Remaining Useful Life (RUL) prediction is a key process for prognostic health management in almost all engineering real-world applications, especially which are in hazardous and challenging environments where the failures and disastrous faults cannot be avoided such as space vehicles and aircraft. This paper proposes a predictive approach based on our proposed algorithm Enhanced Adaptive Guided Differential Evolution (EAGDE) is used to optimize the parameter selection of Support Vector Machine (SVM) to give high RUL prediction accuracy. The advantages of the proposed approach (EAGDE–SVM) are verified using the popular benchmark C-MAPSS which describes the degradation of the aircraft turbofan engine …


Transition Guide And Supports For Families Of Adolescents With Disabilities, Chelsey S. Traut Dec 2022

Transition Guide And Supports For Families Of Adolescents With Disabilities, Chelsey S. Traut

Dissertations, Theses, and Projects

Often when individuals with disabilities transitioned out of high school, there were a variety of repeated questions that teachers and administrators seemed to constantly be answering each year. The first goal of the project was to answer those questions and potentially serve as a resource for teachers and other professionals to answer the questions parents/guardians were asking them. Another goal was that even if the information was different for their district it could at the very least guide professionals and families in the right direction to find answers and support. The literature review provides information about parent/guardian and teacher collaboration …


Enhanced Neurologic Concept Recognition Using A Named Entity Recognition Model Based On Transformers, Sima Azizi, Daniel B. Hier, Donald C. Wunsch Dec 2022

Enhanced Neurologic Concept Recognition Using A Named Entity Recognition Model Based On Transformers, Sima Azizi, Daniel B. Hier, Donald C. Wunsch

Chemistry Faculty Research & Creative Works

Although Deep Learning Has Been Applied to the Recognition of Diseases and Drugs in Electronic Health Records and the Biomedical Literature, Relatively Little Study Has Been Devoted to the Utility of Deep Learning for the Recognition of Signs and Symptoms. the Recognition of Signs and Symptoms is Critical to the Success of Deep Phenotyping and Precision Medicine. We Have Developed a Named Entity Recognition Model that Uses Deep Learning to Identify Text Spans Containing Neurological Signs and Symptoms and Then Maps These Text Spans to the Clinical Concepts of a Neuro-Ontology. We Compared a Model based on Convolutional Neural Networks …


Evidence-Based Study: The Effect Of The Covid-19 Pandemic On Post-Secondary Enrollment And Chosen Fields Of Study, Hannah Fields '25 Dec 2022

Evidence-Based Study: The Effect Of The Covid-19 Pandemic On Post-Secondary Enrollment And Chosen Fields Of Study, Hannah Fields '25

Student Research

The onset of the COVID-19 pandemic in the United States in March of 2020 derailed educational systems at all levels. Specifically, at the post-secondary level, the pandemic sent many students online or forced them to take a fifth year to complete their degrees. As a result, post-secondary enrollment rates are likely to have dropped to reflect these changing post-COVID views surrounding education. Additionally, changing viewpoints about the essentiality of certain jobs and roles changed the chosen fields of study of these same students. Data for this study was collected by way of a short-scale meta-analysis, and enrollment rates were split …


Vertical And Diel Behavior Patterns Of Adult Lemon Sharks (Negaprion Brevirostris) Around The Southeastern Florida And Western Bahamas Coastal Shelves, Jacquelyne Reuder Dec 2022

Vertical And Diel Behavior Patterns Of Adult Lemon Sharks (Negaprion Brevirostris) Around The Southeastern Florida And Western Bahamas Coastal Shelves, Jacquelyne Reuder

All HCAS Student Capstones, Theses, and Dissertations

The lemon shark (Negaprion brevirostris) is a large sub-tropical species found in the western Atlantic Ocean from Virginia to Brazil, including The Bahamas and Caribbean Sea. Previous studies on habitat utilization were conducted on juveniles in The Bahamas, but little is known about vertical depth and temperature preferences of adults. Given the species’ risk to overexploitation and habitat degradation, the IUCN Red List recently listed lemon sharks as Vulnerable. Pop-up satellite archival tags (PSATs) were deployed on lemon sharks (n=7) in 2008 and 2009 off Jupiter, Florida (n=6; two females, four males) and Tiger Beach, Bahamas (n=1; one …


The Effects Of Poor Maternal Nutrition In Ewes On The Growth And Development Of Offspring, Zoey Weisman Dec 2022

The Effects Of Poor Maternal Nutrition In Ewes On The Growth And Development Of Offspring, Zoey Weisman

Honors Scholar Theses

Maternal nutrition is the diet that a mother intakes from before pregnancy through the end of lactation (Martin, 2018). Pregnant ruminants that are raised in pastures are frequently subject to undernutrition due to changes in the quantity and quality of available forage, which results in detrimental effects on the development of muscle and adipose tissues of offspring that can persist into adulthood (Hoffman, 2014). The quality of animal feed varies due to weather changes and climate fluctuations. Sheep usually gestate during the winter, as they are short-day breeders, and during this time, the forage consumed is limited and usually of …


Spatial Variability Of Greenhouse Gases In Blue Carbon Mangrove Ecosystems, Jordan Page Dec 2022

Spatial Variability Of Greenhouse Gases In Blue Carbon Mangrove Ecosystems, Jordan Page

All HCAS Student Capstones, Theses, and Dissertations

Blue carbon ecosystems, including mangrove forests, play a vital role in the global carbon cycle through their carbon sequestration and storage capabilities. Mangrove trees remove CO2 from the atmosphere and store it within these ecosystems. Buildup of organic matter also contributes to high production of methane that is eventually released to adjacent coastal systems and to the atmosphere through air sea gas exchange. It is necessary to investigate environmental conditions that drive greenhouse gas fluctuations to understand how they will change due to climate change and ocean acidification impacts. The goal of this study is to investigate the spatial variability …


The Design, Synthesis, And Investigation Into Small Molecule Modulators Of The Src Homology 2 Domain-Containing Inositol 5’-Phosphatase (Ship), Shea Thomas Meyer Dec 2022

The Design, Synthesis, And Investigation Into Small Molecule Modulators Of The Src Homology 2 Domain-Containing Inositol 5’-Phosphatase (Ship), Shea Thomas Meyer

Dissertations - ALL

The PI3K pathway is a major cell signaling pathway that influences survival and longevity in eukaryotic cells. Abnormal signaling of this pathway has been implicated in a number of disorders, including Alzheimer's disease and cancer. The PI3K pathway utilizes the inositolphospholipid PI(3,4,5)P3 as a key secondary messenger in the transmission of signals from outside the cell to the nucleus. The SRC Homology 2 containing Inositol 5’-Phosphatase (SHIP) also plays a key role in the PI3K pathway, mediating hydrolysis of the inositol phospholipid PI(3,4,5)P3 to PI(3,4)P2. Early testing has shown modulation of SHIP activity through the use of small molecule modulators …


Biological Remediation Of Fragipan, Corey Hale Dec 2022

Biological Remediation Of Fragipan, Corey Hale

Honors College Theses

The fragipan layer in the soil is a naturally occurring subsurface layer that restricts water percolation as well as inhibits root growth. A fragipan layer can be found almost ubiquitously across Southwestern Kentucky. This limits how agriculturalists manage soils in this area. It has been recently discovered by the University of Kentucky that Annual Ryegrass roots produce 3,4 dihydroxyphenylpropionic acid (DHPPA) that reacts with this hardpan to weaken the layer. Certain bacteria, such as Escherichia coli, Lactobacilli, and Bifidobacteria can also synthesize DHPPA through a breakdown process of chlorogenic acid. This reaction typically happens in the human digestive tract. …


Investigating The Contribution Of Marine Viruses To Optical Backscatter In The <0.2 Μm Fraction Of Seawater, Kacey Mae Lange Dec 2022

Investigating The Contribution Of Marine Viruses To Optical Backscatter In The <0.2 Μm Fraction Of Seawater, Kacey Mae Lange

Master's Theses

Marine viruses are the smallest and most abundant biological entities in the ocean. Marine viruses play a significant role in carbon and nutrient cycles through the liberation of dissolved organic matter (DOM) through the lysis of their numerically dominant hosts (i.e. bacteria and phytoplankton). Despite their importance, little is known about how viruses contribute to seawaters inherent optical properties (IOP) of seawater, specifically backscatter. All particles produce backscatter, with their contribution dependent on particle size, concentration, and composition. Living particles contribute 10-20% of the total backscatter with the remaining 80% of unclassified backscatter, “missing backscatter”, contributed by submicron particles ( …


Impacts Of The Poultry Industry In Mississippi, Sara Watts Dec 2022

Impacts Of The Poultry Industry In Mississippi, Sara Watts

Master's Theses

This thesis examines the impacts of the poultry industry in seven counties in the Piney Woods region of South Mississippi: Wayne, Jones, Forrest, Lamar, Jefferson Davis, Marion, and Pike. Current research indicates that the poultry industry has a significant impact on the cultures and economies of rural towns throughout the United States. There is no current research that examines the effects of the poultry industry on residents of the Piney Woods. This thesis addresses that gap in the research and contributes to current understanding of how the industry molds and impacts the lives of those intimately associated with it.

I …


Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Marsha M. Wheeler, Adrienne M. Stilp, Shuquan Rao, Bjarni V. Halldórsson, Doruk Beyter, Jia Wen, Anna V. Mihkaylova, Laura Almasy, John Blangero, Joanne E. Curran Dec 2022

Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Marsha M. Wheeler, Adrienne M. Stilp, Shuquan Rao, Bjarni V. Halldórsson, Doruk Beyter, Jia Wen, Anna V. Mihkaylova, Laura Almasy, John Blangero, Joanne E. Curran

School of Medicine Publications

Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown. Here we utilized whole genome sequencing data in ancestrally diverse participants of the NHLBI Trans Omics for Precision Medicine program (N = 50,675) to detect structural variants associated with hematologic traits. Using single variant tests, we assessed the association of common and rare structural variants with red cell-, white cell-, and platelet-related quantitative …


The Student Movement Volume 107 Issue 11: Have A Merry Christmas! Xoxo, The Student Movement, Solana Campbell, Caryn Cruz, Grace No, Gloria Oh, Nathaniel Reid, Skylor Stark, Ysabelle Fernando, Ceiry Flores, Hannah Cruse, Alexander J. Hess, Alexander Navarro, Rachel Ingram-Clay, Elizabeth Getahun, Kayla-Hope Bruno, Wambui Karanja, Lexie Dunham, Reagan Mccain, Melissa Moore, Elizabeth Dovich Dec 2022

The Student Movement Volume 107 Issue 11: Have A Merry Christmas! Xoxo, The Student Movement, Solana Campbell, Caryn Cruz, Grace No, Gloria Oh, Nathaniel Reid, Skylor Stark, Ysabelle Fernando, Ceiry Flores, Hannah Cruse, Alexander J. Hess, Alexander Navarro, Rachel Ingram-Clay, Elizabeth Getahun, Kayla-Hope Bruno, Wambui Karanja, Lexie Dunham, Reagan Mccain, Melissa Moore, Elizabeth Dovich

The Student Movement v. 107 (2022-2023)

HUMANS

Coping with Finals, Solana Campbell

Meet Jea Erazo, AUSA Public Relations Officer. Interviewed by: Caryn Cruz

Remembering Sharon Dudgeon, Grace No

Women in STEM: Olivia Joyce, Interviewed by: Gloria Oh

ARTS & ENTERTAINMENT

Football Sunday, Nathaniel Reid, Skylor Stark

Student Picks: Christmas Classics, Ysabelle Fernando

NEWS

AFIA x MLS Christmas Party, Ceiry Flores

Boycotts and Bans at the Qatar World Cup, Hannah Cruse

In Loving Memory of Seth Williams, Gloria Oh

IDEAS

How Do We Address Queer Violence?, Alexander J. Hess

Is Reality Really Real When You Aren't Really Looking?, Alexander Navarro

Reflecting on Christmas Traditions, Rachel Ingram-Clay

The …


The Time Is Right For An Antarctic Biorepository Network, Kristin M. O’Brien, Elizabeth L. Crockett, Bryon J. Adams, Charles D. Amsler, Hannah J. Appiah-Madson, Allen Collins, Thomas Desvignes, Sarah Eppley, Multiple Additional Authors Dec 2022

The Time Is Right For An Antarctic Biorepository Network, Kristin M. O’Brien, Elizabeth L. Crockett, Bryon J. Adams, Charles D. Amsler, Hannah J. Appiah-Madson, Allen Collins, Thomas Desvignes, Sarah Eppley, Multiple Additional Authors

Biology Faculty Publications and Presentations

Antarctica is a central driver of the Earth’s climate and health. The Southern Ocean surrounding Antarctica serves as a major sink for anthropogenic CO2 and heat (1), and the loss of Antarctic ice sheets contributes significantly to sea level rise and will continue to do so as the loss of ice sheets accelerates, with sufficient water stores to raise sea levels by 58 m (2). Antarctica's marine environment is home to a number of iconic species, and the terrestrial realm harbors a remarkable oasis for life, much of which has yet to be discovered (3). Distinctive oceanographic features of the …


Clinical Trial Development In Tp53-Mutated Locally Advanced And Recurrent And/Or Metastatic Head And Neck Squamous Cell Carcinoma, Cristina P Rodriguez, Hyunseok Kang, Jessica L Geiger, Barbara Burtness, Christine H Chung, Curtis R Pickering, Carole Fakhry, Quynh Thu Le, Sue S Yom, Thomas J Galloway, Erica Golemis, Alice Li, Jeffrey Shoop, Stuart Wong, Ranee Mehra, Heath Skinner, Nabil F Saba, Elsa R Flores, Jeffrey N Myers, James M Ford, Rachel Karchin, Robert L Ferris, Charles Kunos, Jean M Lynn, Shakun Malik Dec 2022

Clinical Trial Development In Tp53-Mutated Locally Advanced And Recurrent And/Or Metastatic Head And Neck Squamous Cell Carcinoma, Cristina P Rodriguez, Hyunseok Kang, Jessica L Geiger, Barbara Burtness, Christine H Chung, Curtis R Pickering, Carole Fakhry, Quynh Thu Le, Sue S Yom, Thomas J Galloway, Erica Golemis, Alice Li, Jeffrey Shoop, Stuart Wong, Ranee Mehra, Heath Skinner, Nabil F Saba, Elsa R Flores, Jeffrey N Myers, James M Ford, Rachel Karchin, Robert L Ferris, Charles Kunos, Jean M Lynn, Shakun Malik

Faculty, Staff and Student Publications

TP53 mutation is the most frequent genetic event in head and neck squamous cell carcinoma (HNSCC), found in more than 80% of patients with human papillomavirus-negative disease. As mutations in the TP53 gene are associated with worse outcomes in HNSCC, novel therapeutic approaches are needed for patients with TP53-mutated tumors. The National Cancer Institute sponsored a Clinical Trials Planning Meeting to address the issues of identifying and developing clinical trials for patients with TP53 mutations. Subcommittees, or breakout groups, were tasked with developing clinical studies in both the locally advanced and recurrent and/or metastatic (R/M) disease settings as well as …


The Montclarion, December 08, 2022, The Montclarion Dec 2022

The Montclarion, December 08, 2022, The Montclarion

The Montclarion

Student Newspaper of Montclair State University


Plasmon-Enhanced Quantitative Lateral Flow Assay For Detection Of Neisseria Gonorrhoeae, Jiaqi Wang Dec 2022

Plasmon-Enhanced Quantitative Lateral Flow Assay For Detection Of Neisseria Gonorrhoeae, Jiaqi Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

(ng)感染是最常见的性传播感染(STI)之一2020年,CDC共677,769例淋病。。。常常因对抗对抗耐药性高度易受到受到困扰困扰。。。因此因此因此因此因此因此因此因此因此快速准确地地检测检测淋病淋病就尤为尤为重要重要淋病的,但其试验时间长费用高的特点为加强加强全球淋病淋病淋病淋病防治防治工作工作工作工作工作工作淋病淋病淋病淋病淋病淋病淋病淋病淋病淋病感染感染感染感染感染,研制淋病感染感染研制研制研制研制一种灵敏,,特异特异,,迫切需要需要发明发明是基石,它基石,廉价廉价敏感。这工作中中中中,我们我们项项,我们我们了了了了了一种所有所有所有所有所有所有所有所有。我们用等离子体光做为超亮光标记,以克服依赖传统金纳米颗粒做为比色标记的横向流动分析的有限度。


The Expanding Marine Built Environment And Biofilm Formation Processes, Rachel Mugge Dec 2022

The Expanding Marine Built Environment And Biofilm Formation Processes, Rachel Mugge

Dissertations

The marine built environment (i.e., places or things made or modified by humans) in the northern Gulf of Mexico is rapidly expanding and includes over 2,000 known historic shipwrecks, nearly 4,100 artificial reefs, and other built structures for natural resource extraction, marine aquaculture, renewable energy generation, munitions dumping areas, and commercial and recreational activities. While these structures have the potential to develop into artificial reefs, acting as biodiversity hotspots that provide food and shelter and facilitate organism transport, it is unclear how they affect biodiversity and ecosystem function in the marine environment. The success of artificial reefs to become ecosystems …


Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Marsha M Wheeler, Adrienne M Stilp, Shuquan Rao, Bjarni V Halldórsson, Doruk Beyter, Jia Wen, Anna V Mihkaylova, Caitlin P Mchugh, John Lane, Min-Zhi Jiang, Laura M Raffield, Goo Jun, Fritz J Sedlazeck, Ginger Metcalf, Yao Yao, Joshua B Bis, Nathalie Chami, Paul S De Vries, Pinkal Desai, James S Floyd, Yan Gao, Kai Kammers, Wonji Kim, Jee-Young Moon, Aakrosh Ratan, Lisa R Yanek, Laura Almasy, Lewis C Becker, John Blangero, Michael H Cho, Joanne E Curran, Myriam Fornage, Robert C Kaplan, Joshua P Lewis, Ruth J F Loos, Braxton D Mitchell, Alanna C Morrison, Michael Preuss, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Hua Tang, Russell P Tracy, Eric Boerwinkle, Goncalo R Abecasis, Thomas W Blackwell, Albert V Smith, Andrew D Johnson, Rasika A Mathias, Deborah A Nickerson, Matthew P Conomos, Yun Li, Unnur Þorsteinsdóttir, Magnús K Magnússon, Kari Stefansson, Nathan D Pankratz, Daniel E Bauer, Paul L Auer, Alex P Reiner Dec 2022

Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Marsha M Wheeler, Adrienne M Stilp, Shuquan Rao, Bjarni V Halldórsson, Doruk Beyter, Jia Wen, Anna V Mihkaylova, Caitlin P Mchugh, John Lane, Min-Zhi Jiang, Laura M Raffield, Goo Jun, Fritz J Sedlazeck, Ginger Metcalf, Yao Yao, Joshua B Bis, Nathalie Chami, Paul S De Vries, Pinkal Desai, James S Floyd, Yan Gao, Kai Kammers, Wonji Kim, Jee-Young Moon, Aakrosh Ratan, Lisa R Yanek, Laura Almasy, Lewis C Becker, John Blangero, Michael H Cho, Joanne E Curran, Myriam Fornage, Robert C Kaplan, Joshua P Lewis, Ruth J F Loos, Braxton D Mitchell, Alanna C Morrison, Michael Preuss, Bruce M Psaty, Stephen S Rich, Jerome I Rotter, Hua Tang, Russell P Tracy, Eric Boerwinkle, Goncalo R Abecasis, Thomas W Blackwell, Albert V Smith, Andrew D Johnson, Rasika A Mathias, Deborah A Nickerson, Matthew P Conomos, Yun Li, Unnur Þorsteinsdóttir, Magnús K Magnússon, Kari Stefansson, Nathan D Pankratz, Daniel E Bauer, Paul L Auer, Alex P Reiner

Faculty, Staff and Student Publications

Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown. Here we utilized whole genome sequencing data in ancestrally diverse participants of the NHLBI Trans Omics for Precision Medicine program (N = 50,675) to detect structural variants associated with hematologic traits. Using single variant tests, we assessed the association of common and rare structural variants with red cell-, white cell-, and platelet-related quantitative traits …


Genotype Classification Of Moraxella Bovis Using Maldi-Tof Ms Profiles, Hannah G. Olson, John Dustin Loy, Michael L. Clawson, Emily L. Wynn, Matthew M. Hille Dec 2022

Genotype Classification Of Moraxella Bovis Using Maldi-Tof Ms Profiles, Hannah G. Olson, John Dustin Loy, Michael L. Clawson, Emily L. Wynn, Matthew M. Hille

Nebraska Center for Virology: Faculty Publications

Moraxella bovis (M. bovis) is regarded as a causative agent of infectious bovine keratoconjunctivitis (IBK), the most common ocular disease of cattle. Recently, whole genome sequencing identified the presence of two distinct genotypes within M. bovis that differ in chromosome content, potential virulence factors, as well as prophage and plasmid profiles. It is unclear if the genotypes equally associate with IBK or if one is more likely to be isolated from IBK lesions. We utilized 39 strains of M. bovis that had previously undergone whole genome sequencing and genotype classification to determine the utility of matrix-assisted laser desorption/ionization …


Genotype Classification Of Moraxella Bovis Using Maldi-Tof Ms Profiles, Hannah G. Olson, John Dustin Loy, Michael L. Clawson, Emily L. Wynn, Matthew M. Hille Dec 2022

Genotype Classification Of Moraxella Bovis Using Maldi-Tof Ms Profiles, Hannah G. Olson, John Dustin Loy, Michael L. Clawson, Emily L. Wynn, Matthew M. Hille

School of Veterinary and Biomedical Sciences: Faculty Publications

Moraxella bovis (M. bovis) is regarded as a causative agent of infectious bovine keratoconjunctivitis (IBK), the most common ocular disease of cattle. Recently, whole genome sequencing identified the presence of two distinct genotypes within M. bovis that differ in chromosome content, potential virulence factors, as well as prophage and plasmid profiles. It is unclear if the genotypes equally associate with IBK or if one is more likely to be isolated from IBK lesions. We utilized 39 strains of M. bovis that had previously undergone whole genome sequencing and genotype classification to determine the utility of matrix-assisted laser desorption/ionization …


Estimation Of Cotton Canopy Parameters Based On Unmanned Aerial Vehicle (Uav) Oblique Photography, Jinyong Wu, Sheng Wen, Yubin Lan, Xuanchun Yin, Jiantao Zhang, Yufeng Ge Dec 2022

Estimation Of Cotton Canopy Parameters Based On Unmanned Aerial Vehicle (Uav) Oblique Photography, Jinyong Wu, Sheng Wen, Yubin Lan, Xuanchun Yin, Jiantao Zhang, Yufeng Ge

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Background: The technology of cotton defoliation is essential for mechanical cotton harvesting. Agricultural unmanned aerial vehicle (UAV) spraying has the advantages of low cost, high efficiency and no mechanical damage to cotton and has been favored and widely used by cotton planters in China. However, there are also some problems of low cotton defoliation rates and high impurity rates caused by unclear spraying amounts of cotton defoliants. The chemical rate recommendation and application should be based upon crop canopy volume rather than on land area. Plant height and leaf area index (LAI) is directly connected to plant canopy structure. …


Intestinal Gas Production By The Gut Microbiota: A Review, Erasme Mutuyemungu, Mukti Singh, Sean Liu, Devin J. Rose Dec 2022

Intestinal Gas Production By The Gut Microbiota: A Review, Erasme Mutuyemungu, Mukti Singh, Sean Liu, Devin J. Rose

Department of Food Science and Technology: Faculty Publications

In addition to causing embarrassment, intestinal gas can be associated with more serious symptoms. This review provides an overview of gas production by the human gut microbiome and outlines foods associated with intestinal gas. Bacteroides, Ruminococcus, Roseburia, Clostridium, Eubacterium, Desulfovibrio, and Methanobrevibacter are among the most abundant microbes responsible for intestinal gas. More than 99% of intestinal gas is composed of hydrogen, carbon dioxide, and methane, while less than 1% is composed of other odiferous compounds. Food groups associated with intestinal gas include pulses, vegetables, fruits, grains, and, for some individuals, dairy. These foods are …


Safety Of Lenadogene Nolparvovec Gene Therapy Over 5 Years In 189 Patients With Leber Hereditary Optic Neuropathy, Catherine Vignal-Clermont, Patrick Yu-Wai-Man, Nancy J. Newman, Valerio Carelli, Mark L. Moster, Valerie Biousse, Prem S. Subramanian, An-Guor Wang, Sean P. Donahue, Bart P. Leroy, Alfredo A. Sadun, Thomas Klopstock, Robert C. Sergott, Gema Rebolleda Fernandez, Bart K. Chwalisz, Rudrani Banik, Magali Taiel, Michel Roux, José-Alain Sahel Dec 2022

Safety Of Lenadogene Nolparvovec Gene Therapy Over 5 Years In 189 Patients With Leber Hereditary Optic Neuropathy, Catherine Vignal-Clermont, Patrick Yu-Wai-Man, Nancy J. Newman, Valerio Carelli, Mark L. Moster, Valerie Biousse, Prem S. Subramanian, An-Guor Wang, Sean P. Donahue, Bart P. Leroy, Alfredo A. Sadun, Thomas Klopstock, Robert C. Sergott, Gema Rebolleda Fernandez, Bart K. Chwalisz, Rudrani Banik, Magali Taiel, Michel Roux, José-Alain Sahel

Wills Eye Hospital Papers

Purpose

To evaluate the safety profile of lenadogene nolparvovec (Lumevoq) in patients with Leber hereditary optic neuropathy.

Design

Pooled analysis of safety data from 5 clinical studies.

Methods

A total of 189 patients received single unilateral or bilateral intravitreal injections of a recombinant adeno-associated virus 2 (rAAV2/2) vector encoding the human wild-type ND4 gene. Adverse events (AEs) were collected throughout the studies, up to 5 years. Intraocular inflammation and increased intraocular pressure (IOP) were ocular AEs of special interest. Other assessments included ocular examinations, vector bio-dissemination, and systemic immune responses against rAAV2/2.

Results

Almost all patients (95.2%) received 9 × …