Digital Commons Network^™

Arkansas Corn And Grain Sorghum Research Studies 2021, Victor Ford, Jason Kelley, Nathan Mckinney Ii

Arkansas Agricultural Experiment Station Research Series

The 2021 edition of the Arkansas Corn and Grain Sorghum Research Studies Series includes research results on topics pertaining to corn and grain sorghum production, including weed, disease, and insect management; economics; sustainability; irrigation; post-harvest drying; soil fertility; mycotoxins; cover crop management; and research verification program results. Our objective is to capture and broadly distribute the results of research projects funded by the Arkansas Corn and Grain Sorghum Board. The intended audience includes producers and their advisors, current investigators, and future researchers. The Series serves as a citable archive of research results.

Combinatorial Gli Activity Directs Immune Infiltration And Tumor Growth In Pancreatic Cancer, Michael K. Scales, Ashley Velez-Delgado, Nina G. Steele, Hannah E. Schrader, Anna M. Stabnick, Wei Yan, Nayanna M. Mercado Soto, Zeribe C. Nwosu, Craig Johnson, Yaqing Zhang, Daniel J. Salas-Escabillas, Rosa E. Menjivar, H. Carlo Maurer, Howard C. Crawford, Filip Bednar, Kenneth P. Olive, Marina Pasca Di Magliano, Benjamin L. Allen

Surgery Articles

Proper Hedgehog (HH) signaling is essential for embryonic development, while aberrant HH signaling drives pediatric and adult cancers. HH signaling is frequently dysregulated in pancreatic cancer, yet its role remains controversial, with both tumor-promoting and tumor-restraining functions reported. Notably, the GLI family of HH transcription factors (GLI1, GLI2, GLI3), remain largely unexplored in pancreatic cancer. We therefore investigated the individual and combined contributions of GLI1-3 to pancreatic cancer progression. At pre-cancerous stages, fibroblast-specific Gli2/Gli3 deletion decreases immunosuppressive macrophage infiltration and promotes T cell infiltration. Strikingly, combined loss of Gli1/Gli2/Gli3 promotes macrophage infiltration, indicating that subtle changes in Gli expression differentially …

Using Community-Based Participatory Research To Tailor A Diabetes Education Program To An At-Risk Black Church Congregation In The Mid-Atlantic, Samantha A. Mielke

Doctor of Nursing Practice Projects

Background: Prediabetes and diabetes continue to have a high disease burden in the United States (Lin et al., 2018). Many individuals are unaware of their glucose state or the impact impaired glucose can have on their quality adjusted life years and cost of living. The Centers for Disease Control and Prevention (CDC) has underscored the importance of decreasing the incidence of diabetes and has resources available. Still, many communities, particularly minority populations, can benefit from tailoring programs to their specific populations, where typical approaches may not be as beneficial (Joo & Liu, 2020). Additionally, Black American (BA) congregations often have …

Renal Cell Carcinoma Of Pelvic Kidney With Atypical Nodal Metastasis: A Diagnostic Challenge, Roshan-E-Shahid Rana, Muhammad Hammad Ather

Section of Urology

Ectopic pelvic kidney is a known congenital anomaly; however, the presence of renal cell carcinoma (RCC) in an ectopic kidney is rare with the evidence available in the form of a few case reports only. In this case report, we present a case of metastatic RCC in the pelvic kidney which became a diagnostic challenge because of atypical contrast-enhanced computed tomographic (CT) characteristics and unusual pattern of lymph node involvement including cervical lymph node in the absence of visceral metastasis. Because of its unusual location and uncertain vascular anatomy, ectopic kidney poses a surgical challenge. Owing to the rarity of …

Mechanisms Involved In Mitoquinone-Mediated Protection Of H9c2 Cells Against Anti-Cancer Drug Doxorubicin-Induced Cardiotoxicity, Kelly Annie Mercado

PCOM Biomedical Studies Student Scholarship

INTRODUCTION: Due to cardiotoxicity, doxorubicin (DOX), a chemotherapeutic agent, has limited use. Our lab has shown that Mitoquinone (MitoQ) given as a pre-treatment exerted better cardioprotection against DOX-induced cell damage than co-treatment.

OBJECTIVE: This study investigated the underlying mechanisms associated with pre-treating cardiomyocytes with MitoQ and why it demonstrated more potent protection against Doxorubicin-induced cardiotoxicity when compared to co-treatment.

METHODS: Cultured H9c2 cells were dose-dependently treated with DOX alone, MitoQ alone, MitoQ given concurrently with DOX (i.e., co-treatment), or MitoQ given 24 hours prior to DOX (i.e., pre-treatment). Various factors were explored such as cell viability via CCK assay, DOX …

Obstetric Risk In Pregnancy Interacts With Hair Cortisone Levels To Reduce Gestational Length, Wangira Musana, Craig R. Cohen, Miriam Kuppermann, Roy Gerona, Anthony Wanyoro, David Aguilar, Nicole Santos, Sandra J. Weiss, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: Maternal psychological stress has been linked to preterm birth. However, the dierential contribution of psychological stress versus stress hormones is not clear. Studies focus primarily on perceived stress and cortisol, with few assessing its inter-convertible hormone cortisone. Furthermore, little is known about the potential moderating roles of obstetric risk and fetal sex in the relationship between maternal stress and gestational length. This gap in knowledge is particularly evident for rural women who typically experience chronic multiple stressors during pregnancy. We explored the relationship of hormonal and psychological stress to gestational length and the eects of obstetric risks and …

Differences In Hiv, Sti And Other Risk Factors Among Younger And Older Male Sex Workers Who Have Sex With Men In Nairobi, Kenya, Nicholas Muraguri, Jerry Okoth Okal, Marleen Temmerman, Helgar Musyoki, Peter Gichangi

Obstetrics and Gynaecology, East Africa

Introduction: Previous surveys of male sex workers (MSW) in sub-Saharan Africa have not fully documented the HIV and sexually transmitted infections (STIs) rates and vulnerabilities by age category.

Methods: The bio-behavioral survey of MSW in Nairobi, Kenya, utilized respondent-driven sampling to recruit MSW. Structured interviews captured MSW's behavioral aspects, and biological tests for HIV and other STIs.

Results: Analysis of the two age categories, 18–24 years (younger MSW) and 25 years and above (older MSW), shows that of all participants, a significantly higher proportion of younger MSW (59.6% crude, 69.6% RDS-adjusted) were recruited compared to older MSW …

Neuropilin-2 Regulates Androgen-Receptor Transcriptional Activity In Advanced Prostate Cancer, Samikshan Dutta, Navatha Shree Polavaram, Ridwan Islam, Sreyashi Bhattacharya, Sanika Bodas, Thomas Mayr, Sohini Roy, Sophie Alvarez, Marieta I. Toma, Anza Darehshouri, Angelika Borkowetz, Stefanie Conrad, Susanne Fuessel, Manfred Wirth, Gustavo B. Baretton, Paramita Ghosh, Kenneth J. Pienta, David L. Klinkebiel, Surinder K. Batra, Michael H. Muders, Kaustubh Datta

Department of Agronomy and Horticulture: Faculty Publications

Aberrant transcriptional activity of androgen receptor (AR) is one of the dominant mechanisms for developing of castration-resistant prostate cancer (CRPC). Analyzing AR-transcriptional complex related to CRPC is therefore important towards understanding the mechanism of therapy-resistance. While studying its mechanism, we observed that a transmembrane protein called neuropilin-2 (NRP2) plays a contributory role in forming a novel AR-transcriptional complex containing nuclear pore proteins. Using immunogold electron microscopy, high-resolution confocal microscopy, chromatin immunoprecipitation, proteomics, and other biochemical techniques, we delineated the molecular mechanism of how a specific splice variant of NRP2 becomes sumoylated upon ligand stimulation and translocates to the inner nuclear …

Experimental Characterization Of Additively Manufactured Multi-Feather Wingtip Devices, Patricio Garzon

Doctoral Dissertations and Master's Theses

Soaring birds have evolved to fly for long periods of time without flapping their wings. Inspired by the flight of these birds, the proposed thesis presents an experimental investigation focused on wingtip devices designed based on biomimicry. The overarching engineering objective was to reduce the induced drag as a means to improve the fuel efficiency via these experimental wingtips. An associated secondary objective was to establish a method for manufacturing complex structures suitable for wing tunnel testing. A manufacturing technique that involved using composite weaves to reinforce additively manufactured structures was developed. This technique has the potential to reduce manufacturing …

Gender Norms And Gendered Traits, Rowan Bell

Dissertations - ALL

Gender oppression is sustained in part through enforcement of and compliance with gender norms. Understanding how they work is therefore salient to the goal of gender liberation.According to the category-based view, which is common in analytic feminist philosophy, gender norms are assigned to individuals based on their assigned gender category, such as woman or man. I argue that this is insufficient, because it ignores the experiences of those who are marginalized or excluded from those categories. On a category-based view, individual responsiveness to gender norms will track gender category assignment; only individuals assigned the category woman will be responsive to …

Preparation Of Loaded Liposomes By Extrusion And Methods Of Characterization, Maryna Kucheriava, Nicholas Bell, Matt Pitts, Daniel Robertson, Jacob Kammer, Daniel Fologea (Mentor)

Idaho Conference on Undergraduate Research

Adverse drug effects from chemotherapeutic agents are a well-known deterrent and a potential limiting factor for appropriate treatment regimens of tumors. To circumvent these limitations several approaches for precision chemotherapy have been proposed. Among those, liposomes are the most advanced carriers for drugs to tumor sites. Liposomes are spherical lipid structures that mimic the cell membrane, and their ability to protect and transport biologically active molecule is exploited for the purpose of targeted drug delivery. In this respect, our work describes production and characterization of liposomes via extrusion.

We produced liposomes from mixtures of lipids that included Polyethylene glycol (PEG) …

The Effect Of Chief Executive Officer And Board Prior Corporate Social Responsibility Experiences On Their Focal Firm’S Corporate Social Responsibility: The Moderating Effect Of Chief Executive Officer Overconfidence, Marwan Al-Shammari, Hussam Al-Shammari, Soumendra Nath Banerjee, D. Harold Doty

Management Faculty Publications and Presentations

This research aims to examine how the prior experiences of the chief executive officer (CEO) and board influence the focal firm’s Corporate Social Responsibility (CSR) activities. Further, the present study examines how CEO overconfidence influences the diffusion of CSR activities. The authors theorize that overconfident CEOs are influenced more by the corporate strategies they experienced on other boards and less by the corporate strategies experienced by other directors. Through longitudinal analyses of the CSR profiles a sample of S&P 500 companies for the period 2006-2013, the study shows that CEO and board prior CSR experience are positively related to the …

Precision Dentistry In Practice, Diana V. Macri

Publications and Research

A paradigm shift is necessary to improve healthcare delivery and outcomes. Precision medicine and precision dentistry may be able to shift the burden of disease and improve the nation’s oral and overall health.

Alma Link Resolver Subject Report 2021-2022, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics for 2021-2022 on the number of OpenURL requests by Library of Congress classification code made to the Ex Libris Alma link resolver for items held by the University of Rhode Island Libraries.

Information provided includes Classification Code, Classifications, Number of Requests, Number of Clicked Requests, and % Clicks from Requests.

Simulating The Impact Of Crop–Livestock Interaction On Crop Performance Using Dssat, Teerath Rai, Sandeep Kumar, Thandiwe Nleya, Gerrit Hoogenboom

Agronomy, Horticulture and Plant Science Faculty Publications

An integrated crop–livestock system (ICL) can help with enhancing soil quality and crop productivity, ultimately increasing farm income. Field experiments that evalu- ated the impact of cover crops (CCs) and grazing on crop productivity have shown mixed results primarily because of a relatively short duration of the crop–livestock system. Dynamic crop models can help to simulate the long-term impact of soils and crop management on crop yield. The objectives of the current study were to develop a simple simulation methodology for crop–livestock interaction using the Decision Support System for Agrotechnology Transfer (DSSAT) and to evaluate the perfor- mance of CC …

Better Colloidal Lithography: Tilt-Rotate Evaporation Overcomes The Limits Of Plasma Etching, Macayla J. Caso, Michael G. Benton, Kevin M. Mcpeak

Faculty Publications

Colloidal lithography (CL) is a promising method for large-area fabrication of nanohole and nanodot arrays with applications in optical biosensing, separations, and magnetic data storage. However, reducing the diameter of the polystyrene sphere mask by plasma etching unavoidably increases their coefficient of variation (CV) and deforms their shape, thereby limiting the pitch-to-hole-diameter ratio of the resulting nanohole array to less than 3:1 and the minimum hole size to 200 nm with a 10% or better CV. We show that tilt-rotate evaporation colloidal lithography (TRE-CL) breaks the trade-off between hole diameter and polydispersity by leveraging glancing angle evaporation, not plasma etching, …

Sex Differences In The Genetic Architecture Of Cognitive Resilience To Alzheimer’S Disease, Jaclyn M. Eissman, Logan Dumitrescu, Emily R. Mahoney, Alexandra N. Smith, Shubhabrata Mukherjee, Michael L. Lee, Phoebe Scollard, Seo Eun Choi, William S. Bush, Corinne D. Engelman, Qiongshi Lu, David W. Fardo, Emily H. Trittschuh, Jesse Mez, Catherine C. Kaczorowski, Hector Hernandez Saucedo, Keith F. Widaman, Rachel F. Buckley, Michael J. Properzi, Elizabeth C. Mormino, Hyun Sik Yang, Theresa M. Harrison, Trey Hedden, Kwangsik Nho, Shea J. Andrews, Douglas Tommet, Niran Hadad, R. Elizabeth Sanders, Douglas M. Ruderfer, Katherine A. Gifford, Xiaoyuan Zhong, Neha S. Raghavan, Badri Vardarajan, Margaret A. Pericak-Vance, Lindsay A. Farrer, Li San Wang, Carlos Cruchaga, Gerard D. Schellenberg, Nancy J. Cox, Jonathan L. Haines, C. Dirk Keene, Andrew J. Saykin, Eric B. Larson, Reisa A. Sperling, Richard Mayeux, Michael L. Cuccaro, David A. Bennett, Julie A. Schneider, Paul K. Crane, Angela L. Jefferson, Timothy J. Hohman

Sanders-Brown Center on Aging Faculty Publications

Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are resilient to the cognitive consequences of Alzheimer's disease neuropathology may uncover novel therapeutic targets to treat Alzheimer's disease. It is well established that there are sex differences in response to Alzheimer's disease pathology, and growing evidence suggests that genetic factors may contribute to these differences. Taken together, we sought to elucidate sex-specific genetic drivers of resilience.

We extended our recent large scale genomic analysis of resilience in which we harmonized cognitive data across four cohorts …

School Improvement Plan: Updating Curriculum, Technology And Classrooms For Education 4.0, David Carter

Master's Theses & Capstone Projects

This school improvement plan describes Education 4.0 and elucidates the critical need for updating school curriculum and teaching methods. Our education system is largely outdated and ill prepares students for their future. The following improvement plan seeks to transform pedagogy into that which is student centered. To do this, schools must update their curriculum and teaching methods, implement the latest technology, and redesign the classroom setting. Through this project, I will identify the reasons for needed change in schools and explain Education 4.0.

Improvements For Trauma Informed Professional Development, Jennifer Wright

Master's Theses & Capstone Projects

The growing knowledge base of trauma contributes to the field of education, specifically early childhood. This knowledge points to the direction of trauma informed care in the early years. With the need to support both students and teachers, the content and method of professional development needs special consideration. Past research indicates the Breakthrough Series Collaborative is a successful way to implement meaningful and lasting professional development. Research also shows MindUP curriculum as successful for giving both staff and students tools to self-regulate and discuss big emotions. This school improvement plan combines the methodology and curriculum proving successful the Attitudes Related …

Implementation Of A Tier Ii Math Intervention Program, Taylor Torres

Master's Theses & Capstone Projects

The impact of COVID-19 has been detrimental to student success. School closings reduced learning for all students but especially for primary students who missed critical foundational skills. Tier II math interventions within the MTSS framework show evidence of growth for students of all ages and needs. This research-based approach is a logical response to combatting the damage caused by the pandemic. Several successful research studies on mathematics intervention will provide promise of replication in other schools. This school improvement plan will outline actions toward implementing Tier II math interventions in a rural Iowa elementary school.

Caring For Creation: An Elementary School Recycling And Food Waste Program, Melanie Haugh

Master's Theses & Capstone Projects

Much of the waste in landfills could be diverted into recycled or reused materials. This includes organic materials such as food waste as well as recycled materials such as paper and plastic. To solve this problem, the state of California is taking action to reduce landfill waste by 2025. This school improvement plan provides a private Christian elementary school in Southern California with a comprehensive plan to educate students, educators, and staff on how to care for God’s creation through pro-environmental behaviors, including steps to assist in the separation of food waste and recyclables. A review of the literature is …

Alma Link Resolver Title & Issn Report (Top 500) 2021-2022, Andrée J. Rathemacher

Technical Services Reports and Statistics

Statistics for 2021-2022 on the total number of OpenURL requests by journal title and ISSN made to the Ex Libris Alma link resolver for items held by the University of Rhode Island Libraries. Includes only the top 500 journals.

Information provided includes journal Title, ISSN, EISSN, Number of Requests, Number of Clicked Requests, % Clicks from Requests.

Communiqué: College Of Humanities, Arts & Sciences Alumni Magazine, Volume 10, Summer 2022, University Of Northern Iowa. College Of Humanities, Arts, And Sciences.

Communiqué: College of Humanities, Arts & Sciences Alumni Magazine

Contents:

EVERY ISSUE
Message from the Dean --- 4
Donor Feature --- 5
CHAS Briefs --- 38
New Faculty --- 42
Class Notes --- 44

FEATURES
Photographing Art --- 6
Video Games Meet Neuroscience --- 10
James Webb Telescope --- 14
Meskwaki Soil Testing --- 18
Actuarial Science Grad --- 34

STORIES
Speech Therapy in Africa --- 22
Diversity in Theatre --- 24
Curating a Crab Collection --- 26
Working on a COVID Drug --- 28
Women in STEM --- 29
Speech & Debate Success --- 30
Opera-Singing Sensation --- 32
Historic NAR Team --- 40
Benitez Wins Fellowship --- …

Molecular Theoretical Model For Lipid Bilayers: Adsorption Of Lipidated Proteins On Lipid Bilayers As A Function Of Bilayer Composition And Curvature, Shauna Celeste Kennard

Theses and Dissertations

Protein localization on biological membranes is motivated by either highly selective recognition of specific target membrane components or nonspecific attraction to general physical properties of the membrane, such as charge, lipid heterogeneity, and curvature. Here we discuss the interaction between lipidated proteins and lipid bilayer membranes from a comprehensive examination of how features of the membrane and its lipid constituents, including lipid composition, headgroup size, degree of tail saturation, tail length (bilayer thickness), and membrane geometry, affect the adsorption ability of the proteins. Of key importance is the strong interconnection among these compositional and morphological elements of the membrane in …

Culturally Tailored Diabetes Self-Management Educational (Dsme) Program And Its Impact On Motivation And Self-Efficacy Among Hispanic Adults With T2dm: A Pilot Study, Andrellie P. Van Wageningen

Doctoral Projects

Type 2 diabetes mellitus in the United States is an epidemic that disproportionately affects Hispanics in the state of California. Many factors have been attributed to this phenomenon because of their unique characteristics. As recent studies have pointed out, their social determinants of health, cultural influences, and genetic predisposition often lead to poor health outcomes and impaired quality of life. A targeted approach is critical in promoting increased diabetes knowledge, enabling skills to master self-care activities, and positive self-care behaviors to avert poor outcomes. The purpose of this doctoral project is to examine whether culturally tailored DSME influences an individual’s …

Addressing Polypharmacy: Implementing The Medication Appropriateness Index Clinical Tool To Increase Deprescribing By Healthcare Providers, Lori Floyd

Doctor of Nursing Practice Projects

Background: Polypharmacy is a national and local issue of concern within healthcare. Deprescribing medications has been identified as a plausible solution for patients experiencing polypharmacy. However, many healthcare providers are unaware of the practice of deprescribing and, if aware, may not be implementing clinical tools for deprescribing effectively. The family medicine clinical site supplies an opportunity for healthcare providers to utilize an evidence-based clinical tool to review medications, identify if inappropriate, and deprescribe if indicated.

Purpose: The purposes of the Doctor of Nursing Practice (DNP) project were to increase deprescribing activity among prescribing healthcare providers and to increase prescribing healthcare …

Implementing The 4ds (Diet, Drinks, Drugs, And Dialysis) To Lower Hyperphosphatemia Among Outpatient Hemodialysis Patients, Morgan Atchison

Doctor of Nursing Practice Projects

Background: Hyperphosphatemia, also known as excess phosphate in the blood, is a problem that continually causes health issues for the outpatient hemodialysis population. Hyperphosphatemia yields multiple health comorbidities and can increase mortality (Rastogi et al., 2021).

Purpose: Hyperphosphatemia is directly correlated with end-stage renal disease (ESRD) (Goyal & Jialal, 2020). This project aimed to decrease the incidence of hyperphosphatemia in the chronic outpatient hemodialysis setting. The primary objective of this project was to increase adherence levels to diet, drinks, drugs, and dialysis (4Ds) in those receiving chronic outpatient hemodialysis in the pursuance of achieving and maintaining blood serum phosphorus levels …

Project Ankle-Brachial Index: Implementation Of An Evidence-Based Peripheral Artery Disease Protocol, Melaney Banks

Doctor of Nursing Practice Projects

Background: Peripheral artery disease (PAD) is a narrowing or blocking of the arteries due to plaque buildup, which prevents oxygen, blood, and other nutrients from getting to the legs. When this buildup reaches a certain point, it becomes atherosclerosis, which is more prevalent in a smoker. Smoking intensifies the problem of plaque buildup if an individual already suffers from PAD. When an individual smokes, the nicotine causes the arteries to constrict and narrow, reducing blood flow further. The ankle-brachial index (ABI) is a simple, cost-effective diagnostic test to identify the presence of PAD which will improve patient outcomes.

Purpose: This …

The Use Of The Centers For Disease Control (Cdc) Outpatient Antibiotic Stewardship Program To Reduce Unnecessary Antibiotic Prescriptions Written For Sinusitis In A Rural Urgent Care Clinic Setting, Melanie Maddox

Doctor of Nursing Practice Projects

Background: The discovery of antibiotics has been a significant success in fighting bacterial infections. According to the Centers for Disease Control (CDC), in 2018, inappropriate prescribing of antibiotics contributed to antibiotic-resistant conditions, which led to 2 million infections, and has killed about 23,000 Americans annually (Chaney, 2018: CDC, 2019). By 2050, 10 million people are expected to die globally due to bacterial resistance, with the cost potentially reaching $100 trillion (WHO, 2019).

Purpose: The purpose of the DNP Project is to decrease unnecessary antibiotic prescriptions for the diagnosis of sinusitis in a rural urgent care clinic and increase provider awareness …

Colin Ruloff And Peter Horban, Eds., Contemporary Arguments In Natural Theology: God And Rational Belief, C. A. Mcintosh

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.