Digital Commons Network^™

Summer 2022, Echoes Staff

Rose Echoes

No abstract provided.

Kalium Channelrhodopsins Are Natural Light-Gated Potassium Channels That Mediate Optogenetic Inhibition, Elena G Govorunova, Yueyang Gou, Oleg A Sineshchekov, Hai Li, Xiaoyu Lu, Yumei Wang, Leonid S Brown, François St-Pierre, Mingshan Xue, John L Spudich

Faculty, Staff and Student Publications

Channelrhodopsins are used widely for optical control of neurons, in which they generate photoinduced proton, sodium or chloride influx. Potassium (K+) is central to neuron electrophysiology, yet no natural K+-selective light-gated channel has been identified. Here, we report kalium channelrhodopsins (KCRs) from Hyphochytrium catenoides. Previously known gated potassium channels are mainly ligand- or voltage-gated and share a conserved K+-selectivity filter. KCRs differ in that they are light-gated and have independently evolved an alternative K+ selectivity mechanism. The KCRs are potent, highly selective of K+ over Na+, and open in less than 1 ms following photoactivation. The permeability ratio PK/PNa of …

A Comparison Of American Women's Experiences With Both Gestational Surrogate Pregnancies And Spontaneous Pregnancies, Jennifer Lahl, Kallie Fell, Kate Bassett, Frances H. Broghammer, William M. Briggs

Dignity: A Journal of Analysis of Exploitation and Violence

This article evaluates the pregnancy experiences of American women by comparing their spontaneous or non-surrogate pregnancies with their gestational surrogate pregnancies. Data were collected through structured interviews using an online video platform. In total, 96 interviews were conducted. Data revealed that a woman was more likely to have a pregnancy that was high-risk during a surrogate pregnancy than during a non-surrogate pregnancy, independent of maternal age or gravidity (OR 11.4, 3.5-36.6; p<.0001). A surrogate pregnancy had three times higher odds of resulting in a cesarean section (p<.0001) and was five times more likely to deliver at an earlier gestational age (p<.0001). Women in this study were significantly more likely to experience postpartum depression following the delivery of surrogate children than after delivering their non-surrogate children (p=.01), and overall, they were more likely to have adverse outcomes during a surrogate pregnancy. The rate of new post-surrogacy chronic health issues for women of color was significantly higher than for women identified as white (p<.0001). We found that women’s economic disadvantage was a major contributor to the decision to proceed with surrogacy. This study confirms that health disparities exist for women with surrogate pregnancies compared to non-surrogate pregnancies, which can lead to long-term complications after a surrogate pregnancy. In terms of biomedical ethics, it raises important social, economic, and political issues related to surrogacy, all requiring further exploration. Future research will build on the present work in further helping us to understand the circumstances and consequences involved for women in surrogacy.

Real-World Experience Of Sotrovimab In High-Risk, Immunocompromised Covid-19 Patients, Navina K. Birk, Saniya Jain, Louis Massoud, Diya Ramesh, Lea Monday, Bruce K. Muma, Jonathan Williams, George Alangaden, Mayur Ramesh

Infectious Diseases Articles

We completed a real-world analysis of 498 consecutive high-risk nonimmunocompromised and immunocompromised patients who received sotrovimab during the B.1.1.529 surge. Emergency department visits/hospitalizations and 30-day all-cause mortality between the 2 groups were similar. When administered early, sotrovimab is effective at preventing coronavirus disease 2019 progression in immunocompromised and nonimmunocompromised patients.

Toxicity Of Formulated Systemic Insecticides Used In Apple Orchard Pest Management Programs To The Honey Bee (Apis Mellifera (L.)), Sarah Heller, Julia Fine, Ngoc B. Phan, Edwin G. Rajotte, David J. Beddinger, Neelendra K. Joshi

Entomology and Plant Pathology Faculty Publications and Presentations

Honey bees (Apis mellifera) are one of the most important pollinating species of flowering plants. Recently, populations of honey bees have been declining due to a combination of factors, including the widespread use of agricultural pesticides. Laboratory studies were conducted to determine the acute oral toxicity of different formulated pesticides to honey bee adults. In particular, we assessed the acute oral toxicity of two neonicotinoids (acetamiprid, Assail 30SG and thiamethoxam, Actara 25WDG) and two other systemic insecticide products (sulfoxaflor, Closer 2SC and flupyradifurone, Sivanto 200SL), all of which are generally used in pest management programs in commercial apple …

Review Of The Nation’S Gratitude: World War I And Citizenship Rights In Interwar Romania, By Maria Bucur, Stefan Cristian Ionescu

History Faculty Articles and Research

A review of The Nation’s Gratitude: World War I and Citizenship Rights in Interwar Romania, by Maria Bucur.

Biometrics And An Ai Bill Of Rights, Margaret Hu

Faculty Publications

This Article contends that an informed discussion on an AI Bill of Rights requires grappling with biometric data collection and its integration into emerging AI systems. Biometric AI systems serve a wide range of governmental purposes, including policing, border security and immigration enforcement, and biometric cyberintelligence and biometric-enabled warfare. These systems are increasingly categorized as "high-risk" when deployed in ways that may impact fundamental constitutional rights and human rights. There is growing recognition that high-risk biometric AI systems, such as facial recognition identification, can pose unprecedented challenges to criminal procedure rights. This Article concludes that a failure to recognize these …

Promoting Diversity As Professionalism, Davis G. Yee

South Carolina Law Review

No abstract provided.

Replicating The Definition Of ‘Forced Pregnancy’ From The Rome Statute In A Future Convention On Crimes Against Humanity: A Tough Pill To Swallow, Julia Tétrault-Provencher

UC Law SF Journal on Gender and Justice

No abstract provided.

Alienation, Commodification, And Commercialization: A Feminist Critique Of Commercial Surrogacy Agreements Through The Lens Of Labor Exploitation And U.S. Organ Donation Law, Isa Elfers

UC Law SF Journal on Gender and Justice

In the United States, organ sale and other forms of paid organ donation agreements are legally prohibited on the grounds that they pose the potential to exploit indigent people for the use of their bodies by the wealthy. However, commercial surrogacy agreements, in which a woman is paid to undergo pregnancy on behalf of another person, form the basis of a booming industry in the United States and abroad. This note posits that commercial surrogacy agreements introduce the same potential for exploitation of the poor as paid organ donation agreements, and that that potential is compounded by specific exploitation of …

Effects Of Standardized Hops (Humulus Lupulus L.) Extract On Joint Health: A Randomized, Placebo-Controlled, Double-Blind, Multiple Dose Study, Ralf Jäger, Brett Bernier, Jason Theodosakis, Gregory Bonfilio, Chad Kerksick, Martin Purpura

Faculty Scholarship

Background: This study’s aim was to evaluate the efficacy and safety of 14-days oral supplementation of a standardized hops extract containing 30% alpha acids, Humulus lupulus L. on individuals with osteoarthritis of the knee.

Methods: Thirty-three subjects (26 female, 7 male, 57.0 ± 6.9 years) participated in this randomized, double-blind, multi-dose study. Perceived pain (WOMAC), 20-meter walking performance and clinical safety markers (metabolic panel) was evaluated after 0 and 14 days of standardized hops extract (Perluxan®, 1 g/day [HOPS1G], n = 11 or 2 g/day [HOPS2G], n = 10 or placebo [PLA], n = 12). Changes in WOMAC …

Collaborative Textbook On English Syntax (Version 1.0), Matt Garley, Karl Hagen, The Students Of Eng 270 At York College / Cuny

Open Educational Resources

No abstract provided.

Undergraduate And Graduate Course Descriptions, 2022 Summer, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Summer 2022.

The Alpha-7 Nicotinic Acetylcholine Receptor Agonist Gts-21 Engages The Glucagon-Like Peptide-1 Incretin Hormone Axis To Lower Levels Of Blood Glucose In Db/Db Mice, Qinghe Meng, Oleg G. Chepurny, Colin A. Leech, Napat Pruekprasert, Megan E. Molnar, James Jason Collier, Robert N. Cooney, George G. Holz

Division of Basic Science Faculty Publications

Aim: To establish if alpha-7 nicotinic acetylcholine receptor (α7nAChR) agonist GTS-21 exerts a blood glucose-lowering action in db/db mice, and to test if this action requires coordinate α7nAChR and GLP-1 receptor (GLP-1R) stimulation by GTS-21 and endogenous GLP-1, respectively. Materials and Methods: Blood glucose levels were measured during an oral glucose tolerance test (OGTT) using db/db mice administered intraperitoneal GTS-21. Plasma GLP-1, peptide tyrosine tyrosine 1-36 (PYY1-36), glucose-dependent insulinotropic peptide (GIP), glucagon, and insulin levels were measured by ELISA. A GLP-1R–mediated action of GTS-21 that is secondary to α7nAChR stimulation was evaluated using α7nAChR and GLP-1R knockout (KO) mice, or …

A Pilot Study Of A Cohort-Based Solution-Focused Wellness Group For Graduate Students Using Solution-Focused Coaching, James Beauchemin, Danya Krueger, Jennifer Newman, Paul Beitelspacher

Journal of Solution Focused Practices

Graduate students experience heightened levels of stress, compromising their well-being and predisposing them to mental health disorders. Graduate students are over six times more likely to experience depression and anxiety than the general population. Despite the presence of counseling services on college and university campuses, graduate students are less likely to access these services and more prone to utilize alternative institutional supports (i.e., faculty advisors or peer counselors). This pilot study assessed the effectiveness of a six-week solution focused wellness (SFW) group intervention with a graduate program cohort using a pre-post, mixed-methods design. A total of twenty-seven (N = 27) …

July 2022 Complete

Journal of Solution Focused Practices

No abstract provided.

Muc1 And Polarity Markers Inadl And Scrib Identify Salivary Ductal Cells, D Wu, P J Chapela, C M L Barrows, D A Harrington, D D Carson, R L Witt, N G Mohyuddin, S Pradhan-Bhatt, M C Farach-Carson

Faculty, Staff and Student Publications

Current treatments for xerostomia/dry mouth are palliative and largely ineffective. A permanent clinical resolution is being developed to correct hyposalivation using implanted hydrogel-encapsulated salivary human stem/progenitor cells (hS/PCs) to restore functional salivary components and increase salivary flow. Pluripotent epithelial cell populations derived from hS/PCs, representing a basal stem cell population in tissue, can differentiate along either secretory acinar or fluid-transporting ductal lineages. To develop tissue-engineered salivary gland replacement tissues, it is critical to reliably identify cells in tissue and as they enter these alternative lineages. The secreted protein α-amylase, the transcription factor MIST1, and aquaporin-5 are typical markers for acinar …

Determining Contributing Factors For Passenger Airline Pilot Perceived Fatigue, Heidi C. Kim

Doctoral Dissertations and Master's Theses

Fatigue is a recurring concern for pilots and continues to be a common contributing cause of aircraft accidents. The purpose of the dissertation was to determine factors that influence fatigue in commercial airline pilots. The ability to accurately associate fatigue in pilots before a flight begins could have a profound and meaningful impact on aviation safety. Seven factors were identified in the literature review as having possible predictive capabilities of perceived fatigue in pilots working for passenger carriers, including time awake, perceived stress, sleep quality, hours of sleep, age, typically scheduled start time, and hours on duty.

An …

Acylsugars Protect Nicotiana Benthamiana Against Insect Herbivory And Desiccation, Honglin Feng, Lucia Acosta-Gamboa, Lars H. Kruse, Jake D. Tracy, Seung Ho Chung, Alba Ruth Nava Fereira, Sara Shakir, Hongxing Xu, Garry Sunter, Michael A. Gore, Clare L. Casteel, Gaurav D. Moghe, Georg Jander

Faculty Publications

Key message: Nicotiana benthamiana acylsugar acyltransferase (ASAT) is required for protection against desiccation and insect herbivory. Knockout mutations provide a new resource for investigation of plant-aphid and plant-whitefly interactions. Abstract: Nicotiana benthamiana is used extensively as a transient expression platform for functional analysis of genes from other species. Acylsugars, which are produced in the trichomes, are a hypothesized cause of the relatively high insect resistance that is observed in N. benthamiana. We characterized the N. benthamiana acylsugar profile, bioinformatically identified two acylsugar acyltransferase genes, ASAT1 and ASAT2, and used CRISPR/Cas9 mutagenesis to produce acylsugar-deficient plants for investigation of insect resistance …

Ethnic Discrimination And Alcohol-Related Problem Severity Among Hispanic/Latin Drinkers: The Role Of Social Anxiety In The Minority Stress Model, Julia D. Buckner, Elizabeth M. Lewis, Justin M. Shepherd, Michael J. Zvolensky

Faculty Publications

Introduction: Hispanic/Latin individuals in the U.S. experience many health disparities, including worse alcohol-related outcomes. Thus, identifying psycho-sociocultural factors that may play a role in alcohol-related problems among these individuals is vital to informing prevention and treatment efforts. Minority stress-based models of alcohol misuse posit that some Hispanic/Latin individuals may drink (and continue to drink despite drinking-related problems) to alleviate negative affect associated with experiencing ethnic discrimination. Yet, little research has directly tested this hypothesis. Given the social nature of both ethnic discrimination and drinking, it follows that experiencing more ethnic discrimination could be related to greater social anxiety and some …

Special Issue: Emerging Paradigms In Insulin Resistance, J. Jason Collier, Susan J. Burke

Division of Basic Science Faculty Publications

No abstract provided.

From Soils To Streams: Connecting Terrestrial Carbon Transformation, Chemical Weathering, And Solute Export Across Hydrological Regimes, Hang Wen, Pamela L. Sullivan, Sharon A. Billings, Hoori Ajami, Alejandro Cueva, Alejandro Flores, Daniel R. Hirmas, Aaron N. Koop, Katie Murenbeeld, Xi Zhang, Li Li

Faculty Publications

Soil biota generates carbon that exports vertically to the atmosphere (CO2) and transports laterally to streams and rivers (dissolved organic and inorganic carbon, DOC and DIC). These processes, together with chemical weathering, vary with flow paths across hydrological regimes; yet an integrated understanding of these interactive processes is still lacking. Here we ask: How and to what extent do subsurface carbon transformation, chemical weathering, and solute export differ across hydrological and subsurface structure regimes? We address this question using a hillslope reactive transport model calibrated using soil CO2 and water chemistry data from Fitch, a temperate forest at the ecotone …

The Perfect Storm? Covid-19 And Substance Use Amongst Social Work Students In The Usa, Youn Kyoung Kim, Sung Seek Moon, Mansoo Yu, Mee Young Um, Arati Maleku, Omoshola Kehinde, David Pooler

Faculty Publications

During the COVID-19 pandemic, health risk behaviours related to substance use have been recognised as a significant public health concern amongst university students. Understanding the mechanisms of substance use behaviours, including those used to cope with COVID-19-related stressors, is imperative to curate targeted prevention efforts. To that end, we examined substance use prevalence and its associations with socio-demographic characteristics, preventive behaviours, and mental health amongst US social work students. We collected data from 457 students across all degree levels (BSW, MSW and PhD) from July to August 2020 through an online survey, to examine thirty-day patterns of substance use behaviours …

Alliance Of Randomized Trials Of Medicine Vs Metabolic Surgery In Type 2 Diabetes (Armms-T2d): Study Rationale, Design, And Methods, Donald C. Simonson, Bo Hu, David E. Arterburn, Philip R. Schauer, Sangeeta R. Kashyap, Anita P. Courcoulas, David E. Cummings, Mary Elizabeth Patti, William F. Gourash, Ashley H. Vernon, John M. Jakicic, John P. Kirwan

Division of Basic Science Faculty Publications

Aims: Long-term data from randomized clinical trials comparing metabolic (bariatric) surgery versus a medical/lifestyle intervention for treatment of patients with obesity/overweight and type 2 diabetes (T2D) are lacking. The Alliance of Randomized Trials of Medicine vs Metabolic Surgery in Type 2 Diabetes (ARMMS-T2D) is a consortium of four randomized trials designed to compare long-term efficacy and safety of surgery versus medical/lifestyle therapy on diabetes control and clinical outcomes. Materials and Methods: Patients with T2D and body mass index (BMI) of 27-45 kg/m2 who were previously randomized to metabolic surgery (Roux-en-Y gastric bypass, adjustable gastric band, or sleeve gastrectomy) versus medical/lifestyle …

Edwardsiella Ictaluri T3ss Effector Esen Modulates Expression Of Host Genes Involved In The Immune Response, Lidiya P. Dubytska, Ranjan Koirala, Azhia Sanchez, Ronald Thune

Faculty Publications

The type III secretion system (T3SS) effector EseN is encoded on the Edwardsiella ictaluri chromosome and is homologous to a family of T3SS effector proteins with phosphothreonine lyase activity. Previously we demonstrated that E. ictaluri invasion activates extracellular signal-regulated kinases 1 and 2 (ERK1/2) early in the infection, which are subsequently inactivated by EseN. Com-parative transcriptomic analysis showed a total of 753 significant differentially expressed genes in head-kidney-derived macrophages (HKDM) infected with an EseN mutant (∆EseN) compared to HKDM infected with wild-type (WT) strains. This data strongly indicates classical activation of macrophages (the M1 phenotype) in response to E. ictaluri …

Low-Light Shadow Imaging Using Quadrature-Noise Detection With A Camera, Savannah L. Cuozzo, Pratik J. Barge, Nikunjkumar Prajapati, Narayan Bhusal, Hwang Lee, Lior Cohen, Irina Novikova, Eugeniy E. Mikhailov

Faculty Publications

This paper experimentally demonstrates an imaging technique based on quadrature noise modification after interaction with an opaque object. By using a homodyne-like detection scheme, the detrimental effect of the camera dark noise is eliminated, making this approach particularly attractive for imaging scenarios which require weak illumination. As an example, the image of an object illuminated with a squeezed vacuum is reconstructed using a total of 800 probing photons, utilizing less than one photon per frame on average.

Conditional Quantum Plasmonic Sensing, Fatemeh Mostafavi, Zeinab Jafari, Michelle L.J. Lollie, Chenglong You, Israel De Leon, Omar S. Magaña-Loaiza

Faculty Publications

The possibility of using weak optical signals to perform sensing of delicate samples constitutes one of the main goals of quantum photonic sensing. Furthermore, the nanoscale confinement of electromagnetic near fields in photonic platforms through surface plasmon polaritons has motivated the development of highly sensitive quantum plasmonic sensors. Despite the enormous potential of plasmonic platforms for sensing, this class of sensors is ultimately limited by the quantum statistical fluctuations of surface plasmons. Indeed, the fluctuations of the electromagnetic field severely limit the performance of quantum plasmonic sensing platforms in which delicate samples are characterized using weak near-field signals. Furthermore, the …

The Dual Nature Of The Nucleolus, Alan Tartakoff, Patrick Dimario, Eduard Hurt, Brian Mcstay, Vikram Govind Panse, David Tollervey

Faculty Publications

The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as “being a multilayered condensate,” and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.

Mitochondrial Dna And Other Lines Of Evidence Clarify Species Diversity In The Peromyscus Truei Species Group (Cricetidae: Neotominae), Giovani Hernández-Canchola, Livia León-Paniagua, Jacob A. Esselstyn

Faculty Publications

Deer mice (genus Peromyscus) are among the commonest small mammals in the Nearctic zoogeographic region. Nevertheless, systematic relationships are only partially settled and numerous taxonomic questions await resolution. For instance, researchers have found that some members of the Peromyscus truei species group contain high levels of genetic divergence that could indicate the presence of cryptic species. We analyzed the systematics and phylogenetic relationships of the P. truei group using new and previously published mitochondrial cytochrome b sequences. Our analyses verify several earlier conclusions, but we also detected new clades that deserve recognition. Considering their mitochondrial distinctiveness, allopatric ranges, and previously …

Monarch, Philip Walzer (Editor)

Monarch Magazine

Summer 2022 issue of Monarch, the Old Dominion University Magazine.

Subtitled: R1: The Gold Standard of Research