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2022

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Articles 10681 - 10710 of 32143

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Webcsea: Web-Based Cell-Type-Specific Enrichment Analysis Of Genes, Yulin Dai, Ruifeng Hu, Andi Liu, Kyung Serk Cho, Astrid Marilyn Manuel, Xiaoyang Li, Xianjun Dong, Peilin Jia, Zhongming Zhao Jul 2022

Webcsea: Web-Based Cell-Type-Specific Enrichment Analysis Of Genes, Yulin Dai, Ruifeng Hu, Andi Liu, Kyung Serk Cho, Astrid Marilyn Manuel, Xiaoyang Li, Xianjun Dong, Peilin Jia, Zhongming Zhao

Faculty, Staff and Student Publications

Human complex traits and common diseases show tissue- and cell-type- specificity. Recently, single-cell RNA sequencing (scRNA-seq) technology has successfully depicted cellular heterogeneity in human tissue, providing an unprecedented opportunity to understand the context-specific expression of complex trait-associated genes in human tissue-cell types (TCs). Here, we present the first web-based application to quickly assess the cell-type-specificity of genes, named Web-based Cell-type Specific Enrichment Analysis of Genes (WebCSEA, available at https://bioinfo.uth.edu/webcsea/). Specifically, we curated a total of 111 scRNA-seq panels of human tissues and 1,355 TCs from 61 different general tissues across 11 human organ systems. We adapted our previous decoding tissue-specificity …

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A Mixed Method Approach To Understanding Team Members' Perspectives After Receiving Problem-Solving Training And Performance Feedback, Alexander Mark Julian Jul 2022

A Mixed Method Approach To Understanding Team Members' Perspectives After Receiving Problem-Solving Training And Performance Feedback, Alexander Mark Julian

Theses and Dissertations

While countless studies have collected data on the effectiveness of various problem- solving models, few have attempted to identify which components of the training process are helpful to participants. Two teacher teams consisting of seven participants were trained in an adapted version of the Team-initiated Problem Solving (TIPS) model, observed each meeting, and provided performance feedback regarding how well they had adhered to the model. A mixed method approach was used to collect quantitative data in the form of the teams' adherence to the TIPS model and qualitative data once successful adherence to the model had been shown. Researchers interviewed …

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Coexistence Of Vitreous And Crystalline Phases Of H2o At Ambient Temperature, Ali K. Shargh, Aude Picard, Rostislav Hrubiak, Dongzhou Zhang, Russell J. Hemley, Shanti Deemyad, Niaz Abdolrahim, Saveez Saffarian Jul 2022

Coexistence Of Vitreous And Crystalline Phases Of H2o At Ambient Temperature, Ali K. Shargh, Aude Picard, Rostislav Hrubiak, Dongzhou Zhang, Russell J. Hemley, Shanti Deemyad, Niaz Abdolrahim, Saveez Saffarian

Life Sciences Faculty Research

Formation of vitreous ice during rapid compression of water at room temperature is important for biology and the study of biological systems. Here, we show that Raman spectra of rapidly compressed water at greater than 1 GPa at room temperature exhibits the signature of high-density amorphous ice, whereas the X-ray diffraction (XRD) pattern is dominated by crystalline ice VI. To resolve this apparent contradiction, we used molecular dynamics simulations to calculate full vibrational spectra and diffraction patterns of mixtures of vitreous ice and ice VI, including embedded interfaces between the two phases. We show quantitatively that Raman spectra, which probe …

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Cd169 (Siglec-1) As A Robust Human Cell Biomarker Of Toll-Like Receptor 9 Agonist Immunotherapy, Stine Sofie Frank Lende, Marie H. Pahus, Ida Monrad, Rikka Olesen, Anna Mahr, Line K. Vibholm, Lars Østergaard, Ole Schmeltz Søgaard, Anna Halling Folkmar Andersen, Paul Denton, Martin Tolstrup Jul 2022

Cd169 (Siglec-1) As A Robust Human Cell Biomarker Of Toll-Like Receptor 9 Agonist Immunotherapy, Stine Sofie Frank Lende, Marie H. Pahus, Ida Monrad, Rikka Olesen, Anna Mahr, Line K. Vibholm, Lars Østergaard, Ole Schmeltz Søgaard, Anna Halling Folkmar Andersen, Paul Denton, Martin Tolstrup

Biology Faculty Publications

Immunotherapy is a promising therapeutic area in cancer and chronic viral infections. An important component of immunotherapy in these contexts is the activation of innate immunity. Here we investigate the potential for CD169 (Siglec 1) expression on monocytes to serve as a robust biomarker for activation of innate immunity and, particular, as a proxy for IFN-α production. Specifically, we investigated the effects of Toll-like receptor 9 agonism with MGN1703 (lefitolimod) across experimental conditions ex vivo, in humanized mice, and in clinical trial participants. Ex vivo we observed that the percentage of classical monocytes expressing CD169 increased dramatically from …

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Coordinating Tiny Limbs And Long Bodies: Geometric Mechanics Of Lizard Terrestrial Swimming, Baxi Chong, Tianyu Wang, Eva Erickson, Philip J. Bergmann, Daniel I. Goldman Jul 2022

Coordinating Tiny Limbs And Long Bodies: Geometric Mechanics Of Lizard Terrestrial Swimming, Baxi Chong, Tianyu Wang, Eva Erickson, Philip J. Bergmann, Daniel I. Goldman

Biology

Although typically possessing four limbs and short bodies, lizards have evolved diverse morphologies, including elongate trunks with tiny limbs. Such forms are hypothesized to aid locomotion in cluttered/fossorial environments but propulsion mechanisms (e.g., the use of body and/or limbs to interact with substrates) and potential body/limb coordination remain unstudied. Here, we use biological experiments, a geometric theory of locomotion, and robophysical models to investigate body–limb coordination in diverse lizards. Locomotor field studies in short-limbed, elongate lizards (Brachymeles and Lerista) and laboratory studies of fully limbed lizards (Uma scoparia and Sceloporus olivaceus) and a snake (Chionactis occipitalis) reveal that body-wave dynamics …

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Psychology In The Modern World, Kutay Agardici Jul 2022

Psychology In The Modern World, Kutay Agardici

Open Educational Resources

This syllabus is created for the two courses I will be teaching at City College in the psychology dept. Topics include cognition, language, learning, memory, nature vs. nurture, abnormal psychology, social psychology, etc.

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Uncovering 'Hidden' Signals: Previously Presumed Visual Signals Likely Generate Air Particle Movement, Pallabi Kundu, Noori Choi, Aaron S. Rundus, Roger D. Santer Jul 2022

Uncovering 'Hidden' Signals: Previously Presumed Visual Signals Likely Generate Air Particle Movement, Pallabi Kundu, Noori Choi, Aaron S. Rundus, Roger D. Santer

Psychology Faculty Publications

Wolf spiders within the genus Schizocosa have become a model system for exploring the form and function of multimodal communication. In terms of male signaling, much past research has focused on the role and importance of dynamic and static visual and substrate-borne vibratory communication. Studies on S. retrorsa, however, have found that female-male pairs were able to successfully mate in the absence of both visual and vibratory stimuli, suggesting a reduced or non-existent role of these signaling modalities in this species. Given these prior findings, it has been suggested that S. retrorsa males may utilize an additional signaling modality during …

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The Ubiquitin Ligase Siah2 Is A Female-Specific Regulator Of Circadian Rhythms And Metabolism, Tsedey Mekbib, Ting Chung Suen, Aisha Rollins-Hairston, Kiandra Smith, Ariel Armstrong, Cloe Gray, Sharon Owino, Kenkichi Baba, Julie E. Baggs, J. Christopher Ehlen, Gianluca Tosini, Jason P. Debruyne Jul 2022

The Ubiquitin Ligase Siah2 Is A Female-Specific Regulator Of Circadian Rhythms And Metabolism, Tsedey Mekbib, Ting Chung Suen, Aisha Rollins-Hairston, Kiandra Smith, Ariel Armstrong, Cloe Gray, Sharon Owino, Kenkichi Baba, Julie E. Baggs, J. Christopher Ehlen, Gianluca Tosini, Jason P. Debruyne

Neuroscience: Faculty Publications

Circadian clocks enable organisms to predict and align their behaviors and physiologies to constant daily day-night environmental cycle. Because the ubiquitin ligase Siah2 has been identified as a potential regulator of circadian clock function in cultured cells, we have used SIAH2-deficient mice to examine its function in vivo. Our experiments demonstrate a striking and unexpected sexually dimorphic effect of SIAH2-deficiency on the regulation of rhythmically expressed genes in the liver. The absence of SIAH2 in females, but not in males, altered the expression of core circadian clock genes and drastically remodeled the rhythmic transcriptome in the liver by increasing the …

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Circadiomics: Circadian Omic Web Portal, Muntaha Samad, Forest Agostinelli, Tomoki Sato, Kohei Shimaji, Pierre Baldi Jul 2022

Circadiomics: Circadian Omic Web Portal, Muntaha Samad, Forest Agostinelli, Tomoki Sato, Kohei Shimaji, Pierre Baldi

Faculty Publications

Circadian rhythms are a foundational aspect of biology. These rhythms are found at the molecular level in every cell of every living organism and they play a fundamental role in homeostasis and a variety of physiological processes. As a result, biomedical research of circadian rhythms continues to expand at a rapid pace. To support this research, CircadiOmics (http://circadiomics.igb.uci.edu/) is the largest annotated repository and analytic web server for high-throughput omic (e.g. transcriptomic, metabolomic, proteomic) circadian time series experimental data. CircadiOmics contains over 290 experiments and over 100 million individual measurements, across >20 unique tissues/organs, and 11 different species. Users are …

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Creating Receptive Spaces Within The Gallery: A Look Into The Role The Arts Has On Survivors Of Abuse And Its Contribution To The #Metoo Conversation, Tawny Skye Armus Jul 2022

Creating Receptive Spaces Within The Gallery: A Look Into The Role The Arts Has On Survivors Of Abuse And Its Contribution To The #Metoo Conversation, Tawny Skye Armus

Electronic Theses and Dissertations Archive

Through the use of personal place and memory, the artist fosters environments in the gallery to navigate healing from trauma. By cultivating this type of space, survivors of trauma can begin to dissect and navigate through imagery of another survivor in order to visualize ways in which to navigate their own. The artist, Tawny Skye, begins to explore this route by recreating her bedroom in a public gallery. Inviting others to openly gaze at her work, she is bearing her trauma for the audience without directly triggering them with the graphic imagery which is known to cause discomfort, panic attacks, …

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Structure-Activity Relationship And Antitumor Activity Of 1,4-Pyrazine-Containing Inhibitors Of Histone Acetyltransferases P300/Cbp, Shenyou Nie, Fangrui Wu, Jingyu Wu, Xin Li, Chao Zhou, Yuan Yao, Yongcheng Song Jul 2022

Structure-Activity Relationship And Antitumor Activity Of 1,4-Pyrazine-Containing Inhibitors Of Histone Acetyltransferases P300/Cbp, Shenyou Nie, Fangrui Wu, Jingyu Wu, Xin Li, Chao Zhou, Yuan Yao, Yongcheng Song

Faculty, Staff and Students Publications

Acetylation of histone lysine residues by histone acetyltransferase (HAT) p300 and its paralog CBP play important roles in gene regulation in health and diseases. The HAT domain of p300/CBP has been found to be a potential drug target for cancer. Compound screening followed by structure-activity relationship studies yielded a novel series of 1,4-pyrazine-containing inhibitors of p300/CBP HAT with their IC50s as low as 1.4 μM. Enzyme kinetics and other studies support the most potent compound 29 is a competitive inhibitor of p300 HAT against the substrate histone. It exhibited a high selectivity for p300 and CBP, with negligible activity on …

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Epixplorer: A Web Server For Prediction, Analysis And Visualization Of Enhancer-Promoter Interactions, Li Tang, Zhizhou Zhong, Yisheng Lin, Yifei Yang, Jun Wang, James F Martin, Min Li Jul 2022

Epixplorer: A Web Server For Prediction, Analysis And Visualization Of Enhancer-Promoter Interactions, Li Tang, Zhizhou Zhong, Yisheng Lin, Yifei Yang, Jun Wang, James F Martin, Min Li

Children’s Nutrition Research Center Staff Publications

Long distance enhancers can physically interact with promoters to regulate gene expression through formation of enhancer-promoter (E-P) interactions. Identification of E-P interactions is also important for profound understanding of normal developmental and disease-associated risk variants. Although the state-of-art predictive computation methods facilitate the identification of E-P interactions to a certain extent, currently there is no efficient method that can meet various requirements of usage. Here we developed EPIXplorer, a user-friendly web server for efficient prediction, analysis and visualization of E-P interactions. EPIXplorer integrates 9 robust predictive algorithms, supports multiple types of 3D contact data and multi-omics data as input. The …

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Covid-19 Newsletter (Vol. 126), Center For Disaster Medicine, New York Medical College Jul 2022

Covid-19 Newsletter (Vol. 126), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

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Using An Affinity Analysis To Identify Phytoplankton Associations, Weiju Zhu, Zhaojian Ding, Yangdong Pan, Quanxi Wang Jul 2022

Using An Affinity Analysis To Identify Phytoplankton Associations, Weiju Zhu, Zhaojian Ding, Yangdong Pan, Quanxi Wang

Environmental Science and Management Faculty Publications and Presentations

Phytoplankton functional traits can represent particular environmental conditions in complex aquatic ecosystems. Categorizing phytoplankton species into functional groups is challenging and time-consuming, and requires high-level expertise in species autecology. In this study, we introduced an affinity analysis to aid the identification of candidate associations of phytoplankton from two data sets comprised of phytoplankton and environmental information. In the Huaihe River Basin with a drainage area of 270,000 km2 in China, samples were collected from 217 selected sites during the low-water period in May 2013; monthly samples were collected during 2006–2011 in a man-made pond, Dishui Lake. Our results indicated that …

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Banning Books Or Banning Bipoc?, Marisa Shearer Jul 2022

Banning Books Or Banning Bipoc?, Marisa Shearer

NULR Online

No abstract provided.

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The Importance Of Co2 Recapture In The Co2 Concentrating Mechanism Of Chlamydomonas Reinhardtii, Ashwani Rai Jul 2022

The Importance Of Co2 Recapture In The Co2 Concentrating Mechanism Of Chlamydomonas Reinhardtii, Ashwani Rai

LSU Doctoral Dissertations

The aim of this thesis is to investigate the CO2 concentrating mechanism (CCM) of Chlamydomonas reinhardtii and to develop a quick method for estimating the activity of carbonic anhydrases (CAs). The first project demonstrates that there are two almost identical mitochondrial CAs in C. reinhardtii, CAH4 and CAH5, that help to maintain photosynthesis and minimize the leak of CO2 generated by respiration and photorespiration. We used an RNAi approach to reduce the expression of CAH4 and CAH5 so that their physiological functions could be studied. RNAi mutants with low expression of CAH4 and CAH5 have impaired rates …

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Neuromuscular Junction Pathology Is Correlated With Differential Motor Unit Vulnerability In Spinal And Bulbar Muscular Atrophy, Elana Molotsky, Y Liu, Andrew P Lieberman, Diane E Merry Jul 2022

Neuromuscular Junction Pathology Is Correlated With Differential Motor Unit Vulnerability In Spinal And Bulbar Muscular Atrophy, Elana Molotsky, Y Liu, Andrew P Lieberman, Diane E Merry

Department of Biochemistry and Molecular Biology Faculty Papers

Spinal and bulbar muscular atrophy (SBMA) is an X-linked, neuromuscular neurodegenerative disease for which there is no cure. The disease is characterized by a selective decrease in fast-muscle power (e.g., tongue pressure, grip strength) accompanied by a selective loss of fast-twitch muscle fibers. However, the relationship between neuromuscular junction (NMJ) pathology and fast-twitch motor unit vulnerability has yet to be explored. In this study, we used a cross-model comparison of two mouse models of SBMA to evaluate neuromuscular junction pathology, glycolytic-to-oxidative fiber-type switching, and cytoskeletal alterations in pre- and postsynaptic termini of tibialis anterior (TA), gastrocnemius, and soleus hindlimb muscles. …

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Leaf Development In Medicago Truncatula, Liren Du, Samuel Winright Adkins, Mingli Xu Jul 2022

Leaf Development In Medicago Truncatula, Liren Du, Samuel Winright Adkins, Mingli Xu

Faculty Publications

Forage yield is largely dependent on leaf development, during which the number of leaves, leaflets, leaf size, and shape are determined. In this mini-review, we briefly summarize recent studies of leaf development in Medicago truncatula, a model plant for legumes, with a focus on factors that could affect biomass of leaves. These include: floral development and related genes, lateral organ boundary genes, auxin biosynthesis, transportation and signaling genes, and WOX related genes.

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Examining Air Pollution And Forest Health: An Application Of Lichens As Bioindicators And Sentinel-5p Tropomi In Urban State Parks In Shelby County, Tn, Megan Victoria Farrell Jul 2022

Examining Air Pollution And Forest Health: An Application Of Lichens As Bioindicators And Sentinel-5p Tropomi In Urban State Parks In Shelby County, Tn, Megan Victoria Farrell

Electronic Theses and Dissertations Archive

This thesis was undertaken to evaluate the use of epiphytic lichens as bioindicators and Sentinel-5P TROPOMI estimates of NO2 and SO2 pollution to examine the impact of air quality on forest health in two different urban parks (Meeman-Shelby Forest State Park and T.O. Fuller State Park) in Shelby County, Tennessee. Field survey of lichen abundance was cross-validated with Sentinel-5P TROPOMI air pollutant estimates and NDVI values from the National Agricultural Imagery Program (NAIP) were used to correlate forest health with air pollutants. Results showed the plots at Meeman-Shelby Forest State Park had overall higher lichen abundance than the plots at …

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Modeling The Prognostic Impact Of Circulating Tumor Cells Enumeration In Metastatic Breast Cancer For Clinical Trial Design Simulation, Lorenzo Gerratana, Andrew A Davis, Et Al. Jul 2022

Modeling The Prognostic Impact Of Circulating Tumor Cells Enumeration In Metastatic Breast Cancer For Clinical Trial Design Simulation, Lorenzo Gerratana, Andrew A Davis, Et Al.

2020-Current year OA Pubs

Despite the strong prognostic stratification of circulating tumor cells (CTCs) enumeration in metastatic breast cancer (MBC), current clinical trials usually do not include a baseline CTCs in their design. This study aimed to generate a classifier for CTCs prognostic simulation in existing datasets for hypothesis generation in patients with MBC. A K-nearest neighbor machine learning algorithm was trained on a pooled dataset comprising 2436 individual MBC patients from the European Pooled Analysis Consortium and the MD Anderson Cancer Center to identify patients likely to have CTCs ≥ 5/7 mL blood (StageIVaggressive vs StageIVindolent). The model had a 65.1% accuracy and …

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Novel Markers For Liquid Biopsies In Cancer Management: Circulating Platelets And Extracellular Vesicles, Sara Corvigno, Anna Maria Johnson, Kwong-Kwok Wong, Min Soon Cho, Vahid Afshar-Kharghan, David G Menter, Anil K Sood Jul 2022

Novel Markers For Liquid Biopsies In Cancer Management: Circulating Platelets And Extracellular Vesicles, Sara Corvigno, Anna Maria Johnson, Kwong-Kwok Wong, Min Soon Cho, Vahid Afshar-Kharghan, David G Menter, Anil K Sood

Faculty, Staff and Student Publications

Although radiologic imaging and histologic assessment of tumor tissues are classic approaches for diagnosis and monitoring of treatment response, they have many limitations. These include challenges in distinguishing benign from malignant masses, difficult access to the tumor, high cost of the procedures, and tumor heterogeneity. In this setting, liquid biopsy has emerged as a potential alternative for both diagnostic and monitoring purposes. The approaches to liquid biopsy include cell-free DNA/circulating tumor DNA, long and micro noncoding RNAs, proteins/peptides, carbohydrates/lectins, lipids, and metabolites. Other approaches include detection and analysis of circulating tumor cells, extracellular vesicles, and tumor-activated platelets. Ultimately, reliable use …

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Modeling The Prognostic Impact Of Circulating Tumor Cells Enumeration In Metastatic Breast Cancer For Clinical Trial Design Simulation, Lorenzo Gerratana, Jean-Yves Pierga, James M Reuben, Andrew A Davis, Firas H Wehbe, Luc Dirix, Tanja Fehm, Franco Nolé, Rafael Gisbert-Criado, Dimitrios Mavroudis, Salvatore Grisanti, Jose A Garcia-Saenz, Justin Stebbing, Carlos Caldas, Paola Gazzaniga, Luis Manso, Rita Zamarchi, Marta Bonotto, Angela Fernandez De Lascoiti, Leticia De Mattos-Arruda, Michail Ignatiadis, Maria-Teresa Sandri, Daniele Generali, Carmine De Angelis, Sarah-Jane Dawson, Wolfgang Janni, Vicente Carañana, Sabine Riethdorf, Erich-Franz Solomayer, Fabio Puglisi, Mario Giuliano, Klaus Pantel, François-Clément Bidard, Massimo Cristofanilli Jul 2022

Modeling The Prognostic Impact Of Circulating Tumor Cells Enumeration In Metastatic Breast Cancer For Clinical Trial Design Simulation, Lorenzo Gerratana, Jean-Yves Pierga, James M Reuben, Andrew A Davis, Firas H Wehbe, Luc Dirix, Tanja Fehm, Franco Nolé, Rafael Gisbert-Criado, Dimitrios Mavroudis, Salvatore Grisanti, Jose A Garcia-Saenz, Justin Stebbing, Carlos Caldas, Paola Gazzaniga, Luis Manso, Rita Zamarchi, Marta Bonotto, Angela Fernandez De Lascoiti, Leticia De Mattos-Arruda, Michail Ignatiadis, Maria-Teresa Sandri, Daniele Generali, Carmine De Angelis, Sarah-Jane Dawson, Wolfgang Janni, Vicente Carañana, Sabine Riethdorf, Erich-Franz Solomayer, Fabio Puglisi, Mario Giuliano, Klaus Pantel, François-Clément Bidard, Massimo Cristofanilli

Faculty, Staff and Student Publications

Despite the strong prognostic stratification of circulating tumor cells (CTCs) enumeration in metastatic breast cancer (MBC), current clinical trials usually do not include a baseline CTCs in their design. This study aimed to generate a classifier for CTCs prognostic simulation in existing datasets for hypothesis generation in patients with MBC. A K-nearest neighbor machine learning algorithm was trained on a pooled dataset comprising 2436 individual MBC patients from the European Pooled Analysis Consortium and the MD Anderson Cancer Center to identify patients likely to have CTCs ≥ 5/7 mL blood (StageIVaggressive vs StageIVindolent). The model had a 65.1% accuracy and …

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Reduced Rates Of Post-Transplant Recurrent Hepatocellular Carcinoma In Non-Alcoholic Steatohepatitis: A Propensity Score Matched Analysis, Ryan Lamm, Peter J Altshuler, Keyur Patel, Osama Shaheen, Angel Paulo Amante, Jesse Civan, Warren Maley, Adam Frank, Carlo Ramirez, Jaime Glorioso, Ashesh Shah, Hien Dang, Adam S Bodzin Jul 2022

Reduced Rates Of Post-Transplant Recurrent Hepatocellular Carcinoma In Non-Alcoholic Steatohepatitis: A Propensity Score Matched Analysis, Ryan Lamm, Peter J Altshuler, Keyur Patel, Osama Shaheen, Angel Paulo Amante, Jesse Civan, Warren Maley, Adam Frank, Carlo Ramirez, Jaime Glorioso, Ashesh Shah, Hien Dang, Adam S Bodzin

Department of Surgery Faculty Papers

Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) has become the second leading cause of HCC-related liver transplantation in the United States. This study investigated post-transplant recurrence and survival for patients transplanted for NASH-related HCC compared to non-NASH HCC etiologies. Retrospective review of the United Network for Organ Sharing (UNOS) Organ Procurement and Transplantation Network (OPTN) database identified 7,461 patients with HCC—1,405 with underlying NASH and 6,086 with non-NASH underlying diseases. After propensity score matching (PSM) to account for patient- and tumor-related confounders 1,175 remained in each group. Primary outcomes assessed were recurrence rate and recurrence-free survival. Recurrent malignancy at 5 years …

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An Autonomous Sailboat For Environment Monitoring, Y-T Ang, W-K Ng, Y-W Chong, Et Al Jul 2022

An Autonomous Sailboat For Environment Monitoring, Y-T Ang, W-K Ng, Y-W Chong, Et Al

School of Biological and Marine Sciences

The marine environment is constantly at risk from coastal urbanization. The deterioration of coastal and marine environments is evidenced by the decline of mangroves and the biodiversity of such environments and increasing recurrences of algal and jellyfish blooms. There is a lack of environmental data especially in developing countries such as Malaysia to determine the sustainability and impact of the current development on coastal resources. We developed an autonomous sailboat that utilizes the Internet of things technology to collect and analyze ocean water quality data for local authorities to obtain insights into the sustainable development of coastal resources. The USV …

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Heterogeneity Of Gene Trees, Jonathan Nenye Odumegwu Unm Jul 2022

Heterogeneity Of Gene Trees, Jonathan Nenye Odumegwu Unm

Mathematics & Statistics ETDs

Multilocus phylogenetic studies often show a high degree of gene tree heterogeneity —gene trees that have different topologies from each other as well as from the species tree topology. In some cases, this can lead to studies with hundreds of loci having distinct gene tree topologies. The degree of heterogeneity is expected to increase when there is a high degree of incomplete lineage sorting due to short branches (as measured in coalescent units) in the species tree. Other potential sources of heterogeneity include other biological processes such as introgression, recombination within genes, ancestral population structure, gene duplication and loss, and …

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Bi-Allelic Variants In Wnt7b Disrupt The Development Of Multiple Organs In Humans, Jdc Pereira Baptista Jul 2022

Bi-Allelic Variants In Wnt7b Disrupt The Development Of Multiple Organs In Humans, Jdc Pereira Baptista

Peninsula Medical School

BackgroundPulmonary hypoplasia, Diaphragmatic anomalies, Anophthalmia/microphthalmia and Cardiac defects delineate the PDAC syndrome. We aim to identify the cause of PDAC syndrome in patients who do not carry pathogenic variants in RARB and STRA6, which have been previously associated with this disorder.MethodsWe sequenced the exome of patients with unexplained PDAC syndrome and performed functional validation of candidate variants.ResultsWe identified bi-allelic variants in WNT7B in fetuses with PDAC syndrome from two unrelated families. In one family, the fetus was homozygous for the c.292C>T (p.(Arg98*)) variant whereas the fetuses from the other family were compound heterozygous for the variants c.225C>G (p.(Tyr75*)) …

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Ozonated Olive Oil: Enhanced Cutaneous Delivery Via Niosomal Nanovesicles For Melanoma Treatment, Sherif Ashraf Fahmy, Asmaa Ramzy, Amany M. Sawy, Mohamed Nabil Jul 2022

Ozonated Olive Oil: Enhanced Cutaneous Delivery Via Niosomal Nanovesicles For Melanoma Treatment, Sherif Ashraf Fahmy, Asmaa Ramzy, Amany M. Sawy, Mohamed Nabil

Faculty Journal Articles

No abstract provided.

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Screening, Identification And Characteristics Of Acid-Tolerant Lactic Acid Bacteria In Low-Salt Pickles, Sun Xi-Han, Cui Cheng-Bi, Qi Shi-Bo, Qi Xin Jul 2022

Screening, Identification And Characteristics Of Acid-Tolerant Lactic Acid Bacteria In Low-Salt Pickles, Sun Xi-Han, Cui Cheng-Bi, Qi Shi-Bo, Qi Xin

Food and Machinery

Objective:This study focused on screening lactic acid bacteria strains with potential probiotic properties. Methods: Five strains of acid-tolerant lactic acid bacteria were screened from twelve low-salt pickles with salt content ≤6%, identified by 16S rDNA, and their probiotic properties were studied. Results: The five strains were Leuconostoc mesenteroides J2, Lactobacillus paracasei N6, Lactobacillu paraplantarum F8, Weissella cibaria M1 and Weissella cibaria M12. Among them, the relative growth rates of L. paracasei N6, W. cibaria M1 and W. cibaria M12 in pH 4.0 medium were 84.23%, 78.32% and 76.29%, respectively, which had strong acid-tolerant capacity. After digestion with gastric fluid …

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Effect Of Extrusion Treatment On The Functional Properties And Structure Of Pea Protein, Zhang Bai-Ru, Wang Bin, Wang Kun, Dong Yu-Qing, Cui Bo Jul 2022

Effect Of Extrusion Treatment On The Functional Properties And Structure Of Pea Protein, Zhang Bai-Ru, Wang Bin, Wang Kun, Dong Yu-Qing, Cui Bo

Food and Machinery

Objective:This study focuses on the effects of twin-screw extrusion on the functional properties and structure of pea protein. Methods: The color change of pea protein extrudates were analyzed by automatic colorimeter, the water holding capacity and emulsifying characteristics of pea protein were analyzed by chemical analysis. The microstructure of pea protein and its extrudates were observed by scanning electron microscope, and the secondary structure of the extrudates were analyzed by Fourier transform infrared spectroscopy. Results: After extrusion treatment, no significant difference was found in the color of pea protein, indicating that the pea protein had a better product color …

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Isolation And Identification Of Endophytic Bacteria From Fresh Gastrodia Elata And Preliminary Study On Its Functional Activity, Sun Hai-Yan, Liu Xiao, Pei Jin-Jin, Hao Dan-Qing, Wang Er-Nan Jul 2022

Isolation And Identification Of Endophytic Bacteria From Fresh Gastrodia Elata And Preliminary Study On Its Functional Activity, Sun Hai-Yan, Liu Xiao, Pei Jin-Jin, Hao Dan-Qing, Wang Er-Nan

Food and Machinery

Objective:This study aimed to elucidate the activities of endophytic bacteria and their metabolites of Gastrodia elata BI, and to provide theoretical reference for the development of new natural food antibacterial agents and antioxidants.Methods: The endophyte of fresh G. elata in Qinba area was isolated and purified by tissue homogenization and streaking method. The antibacterial, antioxidant and anti-tumor activities of the extract were determined. Furthermore, molecular biology identification was applied for the highly active strains.Results: In this study, four strains were isolated from the inside of fresh G. elata, among which, endophytic bacteria B1 and B2 have good …

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