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Articles 10591 - 10620 of 32143
Full-Text Articles in Entire DC Network
Nabat Ml: Utilizing Deep Learning To Enable Crowdsourced Development Of Automated, Scalable Solutions For Documenting North American Bat Populations, Ali Khalighifar, Benjamin S. Gotthold, Erin Adams, Jenny Barnett, Laura O. Beard, Eric R. Britzke, Paul A. Burger, Kimberly Chase, Zackary Cordes, Paul M. Cryan, Emily Emily, Christopher T. Fill, Scott E. Gibson, G. Scott Haulton, Kathryn M. Irvine, Lara S. Katz, William L. Kendall, Christen A. Long, Oisin Mac Aodha, Tessa Mcburney, Sara Mccarthy, Matthew W. Mckown, Joy O'Keefe, Lucy D. Patterson, Kristopher A. Pitcher, Matthew Rustand, Jordi L. Segers, Kyle Seppanen, Jeremy L. Siemers, Christian Stratton, Bethany R. Straw, Theodore J. Weller, Brian E. Reichert
Nabat Ml: Utilizing Deep Learning To Enable Crowdsourced Development Of Automated, Scalable Solutions For Documenting North American Bat Populations, Ali Khalighifar, Benjamin S. Gotthold, Erin Adams, Jenny Barnett, Laura O. Beard, Eric R. Britzke, Paul A. Burger, Kimberly Chase, Zackary Cordes, Paul M. Cryan, Emily Emily, Christopher T. Fill, Scott E. Gibson, G. Scott Haulton, Kathryn M. Irvine, Lara S. Katz, William L. Kendall, Christen A. Long, Oisin Mac Aodha, Tessa Mcburney, Sara Mccarthy, Matthew W. Mckown, Joy O'Keefe, Lucy D. Patterson, Kristopher A. Pitcher, Matthew Rustand, Jordi L. Segers, Kyle Seppanen, Jeremy L. Siemers, Christian Stratton, Bethany R. Straw, Theodore J. Weller, Brian E. Reichert
Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications
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Bats play crucial ecological roles and provide valuable ecosystem services, yet many populations face serious threats from various ecological disturbances. The North American Bat Monitoring Program (NABat) aims to use its technology infrastructure to assess status and trends of bat populations, while developing innovative and community-driven conservation solutions.
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Here, we present NABat ML, an automated machine-learning algorithm that improves the scalability and scientific transparency of NABat acoustic monitoring. This model combines signal processing techniques and convolutional neural networks (CNNs) to detect and classify recorded bat echolocation calls. We developed our CNN model with internet-based computing resources (‘cloud environment’), and …
Death By A Thousand Cuts? Green Tech, Traditional Knowledge, And Genocide, Regina Menachery Paulose
Death By A Thousand Cuts? Green Tech, Traditional Knowledge, And Genocide, Regina Menachery Paulose
Genocide Studies and Prevention: An International Journal
Traditional Knowledge is a system of knowledge that is passed down through generations of Indigenous and Ethnic Minority Peoples throughout the world. A subset of Traditional Knowledge is Traditional Ecological Knowledge. These knowledge systems are incorporated throughout various international instruments and are considered vital to ways of life for Indigenous and Ethnic Minority Peoples. The author examines the elimination of Traditional Knowledge as a result of green technology. With discussions surrounding ways to obtain “net zero” in response to climate change, the author (re)introduces the notion that the irresponsible push for carbon zero technologies has a horrendous impact on the …
3d-Past: Risk Assessment Model For Predicting Venous Thromboembolism In Covid-19, Yi Lee, Qasim Jehangir, Chun-Hui Lin, Pin Li, Anupam A. Sule, Laila M. Poisson, Venugopal Balijepally, Abdul R. Halabi, Kiritkumar Patel, Geetha Krishnamoorthy, Girish B. Nair
3d-Past: Risk Assessment Model For Predicting Venous Thromboembolism In Covid-19, Yi Lee, Qasim Jehangir, Chun-Hui Lin, Pin Li, Anupam A. Sule, Laila M. Poisson, Venugopal Balijepally, Abdul R. Halabi, Kiritkumar Patel, Geetha Krishnamoorthy, Girish B. Nair
Public Health Sciences Articles
Hypercoagulability is a recognized feature in SARS-CoV-2 infection. There exists a need for a dedicated risk assessment model (RAM) that can risk-stratify hospitalized COVID-19 patients for venous thromboembolism (VTE) and guide anticoagulation. We aimed to build a simple clinical model to predict VTE in COVID-19 patients. This large-cohort, retrospective study included adult patients admitted to four hospitals with PCR-confirmed SARS-CoV-2 infection. Model training was performed on 3531 patients hospitalized between March and December 2020 and validated on 2508 patients hospitalized between January and September 2021. Diagnosis of VTE was defined as acute deep vein thrombosis (DVT) or pulmonary embolism (PE). …
Using Dietary Additives To Improve Palatability Of Diets Containing Single‐Cell Protein From Methanotrophic Bacteria In Yellowtail Kingfish (Seriola Lalandi) Diets, Luke Pilmer, Lindsey Woolley, Alan J. Lymbery, Michael Salini, Gavin Partridge
Using Dietary Additives To Improve Palatability Of Diets Containing Single‐Cell Protein From Methanotrophic Bacteria In Yellowtail Kingfish (Seriola Lalandi) Diets, Luke Pilmer, Lindsey Woolley, Alan J. Lymbery, Michael Salini, Gavin Partridge
Fisheries Research Articles
Single-cell protein (SCP) derived from methanotrophic bacteria has significant potential as a fishmeal alternative in aquafeeds. However, SCP has known palatability issues, to overcome these issues tuna hydrolysate and garlic powder were tested as palatability enhancers against basal diets without these additives. This study tested the inclusion of SCP at four dietary levels of 0%, 10%, 20% and 30%, representing 0%, 25%, 50% and 75% fishmeal replacement in juvenile yellowtail kingfish (Seriola lalandi) (YTK) diets. YTK were fed these diets in triplicate over 35 days. Compared with the control diet, fish fed the SCP10% diet ate less feed, …
Localized Surface Plasmon Resonance Enhancement From Complex Nanoscale Geometries, Jacob T. Waitkus
Localized Surface Plasmon Resonance Enhancement From Complex Nanoscale Geometries, Jacob T. Waitkus
Theses
The unprecedented COVID-19 pandemic highlights the need for portable, sensitive, and accurate biosensors. Here, a novel biosensor that takes advantage of localized surface plasmonic resonance (LSPR) through unique nanoscale geometries was fabricated for sensitive detection of biomarkers. The formation of an adaptable system capable of combining with other sensing methods, such as CRISPR-Cas13a assays, allowed for the detection of specific targets to be realized. In this system, streptavidin-coated gold nanoparticles (GNPs) hybridize with single-stranded RNA (ssRNA) before binding to the surface of gold nanomushrooms (GNMs). Through LSPR enhancement, this binding event produces a red shift in the resonance wavelength peak …
Scale Up Of A Novel Method To Maximize Malonyl-Coa In Escherichia Coli, Clifford Harris Leblanc Iv
Scale Up Of A Novel Method To Maximize Malonyl-Coa In Escherichia Coli, Clifford Harris Leblanc Iv
LSU Master's Theses
The instability of oil’s price along with its limited availability and impact on the environment motivate the search for an alternative feedstock that can sustain the profitability of chemical companies. Industrial biotechnology can promote renewable sources of energy and products by using microorganisms to produce a wide range of chemical compounds. The three-carbon metabolite, malonyl-CoA, can serve as a precursor to a variety of industrial chemicals. The major hurdle with using malonyl-CoA in industry is that its intracellular concentration in Escherichia Coli is very low. Previous attempts to increase the intracellular level of malonyl-CoA have ranged from genetic engineering of …
Genomic Analysis And Therapeutic Development Of Bacteriophages To Treat Bacterial Infections And Parasitic Infestations, Daniel W. Thompson
Genomic Analysis And Therapeutic Development Of Bacteriophages To Treat Bacterial Infections And Parasitic Infestations, Daniel W. Thompson
Theses and Dissertations
Microbiomes are an extremely vast and complex network of microorganisms. Bacteriophages are a key factor in the microbial health of an ecological system and impact the evolution of pathogenic bacterial strains. Bacteria and the phages that infect them have an intricate relationship due to the dependency on the bacterial host for phage replication, the ability of the phage to lyse and kill its host, and the horizontal gene transfer between the host and phage. This thesis aimed to understand how bacteria and the bacteriophages that infect them impact an ecological system, with a focus on disease states. By analyzing all …
Insights Into The Speciation Process From Genomic And Phenotypic Analysis Of An Avian Hybrid Zone In Amazonia, Glaucia Christina Del-Rio
Insights Into The Speciation Process From Genomic And Phenotypic Analysis Of An Avian Hybrid Zone In Amazonia, Glaucia Christina Del-Rio
LSU Doctoral Dissertations
Understanding the outcome of secondary contact is essential to shed light on the mechanisms governing species formation and maintenance. In Amazonia, closely related bird taxa with limited dispersal abilities are often separated by rivers, which presumably act as dispersal barriers. However, at the headwaters, rivers cease to be dispersal barriers, and this generates opportunities for secondary contact. In my dissertation, I studied genomic mechanisms associated with phenotypic differences, mitochondrial DNA structure, and putative reproductive barriers between two hybridizing Amazonian bird species in the genus Rhegmatorhina, a group of antbirds that find their arthropod prey exclusively by following army-ant swarms. …
The Effects Of Overshadowing In Drosophila Melanogaster With Experimentally Evolved Preference, Jill Lee
The Effects Of Overshadowing In Drosophila Melanogaster With Experimentally Evolved Preference, Jill Lee
Theses
As seen in decades of psychology research, preferences play a major role in driving the decision-making process in both humans and animals. Researchers have advocated for using the technique of experimental evolution as a way to address some of the foundational questions on preferences. These preferences can also affect what is later learned and how well new experiences are learned. Salience is usually mentioned as an important component of what could influence preferences. Animals such as Drosophila melanogaster, that lay eggs without any additional maternal or paternal care, it is important to be selective when deciding where to lay …
Guest Editorial: Environmental Degradation And Genocide, Emily Sample, Henry Theriault
Guest Editorial: Environmental Degradation And Genocide, Emily Sample, Henry Theriault
Genocide Studies and Prevention: An International Journal
No abstract provided.
Full Issue 16.1
Genocide Studies and Prevention: An International Journal
No abstract provided.
Mass Violence, Environmental Harm, And The Limits Of Transitional Justice, Rachel Killean, Lauren Dempster
Mass Violence, Environmental Harm, And The Limits Of Transitional Justice, Rachel Killean, Lauren Dempster
Genocide Studies and Prevention: An International Journal
The relationship between the environment and mass violence is complex and multi-faceted. The effects of environmental degradation can destabilize societies and cause conflict. Attacks on the environment can harm targeted groups, and both mass violence and subsequent transitions can have harmful environmental legacies. Given this backdrop, it is notable that the field of transitional justice has paid relatively little attention to the intersections between mass violence and environmental degradation. This article interrogates this inattention and explores the limitations and possibilities of transitional justice as a means of addressing the environmental harms associated with mass violence. The article makes four key …
The Holocaust Paradigm As Paradoxical Imperative In The Century Of Anthropogenic Omnicide, Mark Levene
The Holocaust Paradigm As Paradoxical Imperative In The Century Of Anthropogenic Omnicide, Mark Levene
Genocide Studies and Prevention: An International Journal
The Holocaust and today's climate emergency are not obvious bed fellows. But the post-Holocaust mantra “never again” has also been voiced by some climate activists who see similarities in the failure of Western governments in the 1930s to act to stop Hitler and an equivalent failure now to effectively halt state and corporate drives to biospheric catastrophe. This article examines whether the way Western society has understood the Holocaust in recent decades has relevance to the urge for climate action. It finds the mainstream, state-centred Holocaust paradigm wanting as a framework for empathy and solidarity with those in the Global …
Dossier: The Hunger Plan: The Holocaust, Resource Scarcity, And Preventing Genocide In A Changing Climate, Emily Sample
Dossier: The Hunger Plan: The Holocaust, Resource Scarcity, And Preventing Genocide In A Changing Climate, Emily Sample
Genocide Studies and Prevention: An International Journal
Nazi leadership sought to exploit the biological fear of starvation and scapegoat the Jewish population and other “useless eaters” for taking more than their fair share. The Nazis utilized and hyperbolized well-known prejudices against Jewish people, and entrenched narratives of Jewish parasitism as a threat to current and future German lives. In this analysis, food scarcity was one of several reasons for the Holocaust, and the first step to seeking Lebensraum for pure Germans to live to the highest international standard. This article will focus on different aspects of the complex antisemitic rhetoric surrounding issues of resource scarcity, including Hitler’s …
Khsrp Loss Increases Neuronal Growth And Synaptic Transmission And Alters Memory Consolidation Through Rna Stabilization, Sarah L. Olguin, Priyanka Patel, Courtney N. Buchanan, Michela Dell'orco, Amy S. Gardiner, Robert Cole, Lauren S. Vaughn, Anitha Sundararajan, Joann Mudge, Andrea M. Allen, Pavel Ortinski, Jonathan L. Brigman, Jeffery L. Twiss, Nora L. Perrone-Bizzozero
Khsrp Loss Increases Neuronal Growth And Synaptic Transmission And Alters Memory Consolidation Through Rna Stabilization, Sarah L. Olguin, Priyanka Patel, Courtney N. Buchanan, Michela Dell'orco, Amy S. Gardiner, Robert Cole, Lauren S. Vaughn, Anitha Sundararajan, Joann Mudge, Andrea M. Allen, Pavel Ortinski, Jonathan L. Brigman, Jeffery L. Twiss, Nora L. Perrone-Bizzozero
Faculty Publications
KH-type splicing regulatory protein (KHSRP) regulates levels of several neuronal mRNAs linked to nervous system development and function.
The KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein linked to decay of mRNAs with AU-rich elements. KHSRP was previously shown to destabilize Gap43 mRNA and decrease neurite growth in cultured embryonic neurons. Here, we have tested functions of KHSRP in vivo. We find upregulation of 1460 mRNAs in neocortex of adult Khsrp(-/-) mice, of which 527 bind to KHSRP with high specificity. These KHSRP targets are involved in pathways for neuronal morphology, axon guidance, neurotransmission and long-term memory. Khsrp(-/-) mice …
Quantifying Protein Quality To Understand Protein Homeostasis (Supplemental Data), Hsien-Jung Lavender Lin
Quantifying Protein Quality To Understand Protein Homeostasis (Supplemental Data), Hsien-Jung Lavender Lin
ScholarsArchive Data
This data set includes the supplementary data for chpaters 3 and 4 in the dissertation Quantifying Protein Quality to Understand Protein Homeostasis. It includes various excel worksheets that were used to generate the data reported in the dissertation. We make this data available to the public so anyone who wants to reproduce the results has the resources and access to other perspectives that weren't discussed in depth in the dissertation. Chapter 3 used mass-spectrometry to quantify the surface accessibility differences in human serum albumin (HSA)between patients with and without rheumatoid arthritis (RA). We found certain residues are less reactive …
Characterization Of Mumian And Host Rock In Al-Amerat Cave, Oman., Sara Alqamshouai
Characterization Of Mumian And Host Rock In Al-Amerat Cave, Oman., Sara Alqamshouai
Honors Theses
Mumian is a sticky black-brown material found in the Mumian cave in Wadi Al Mayh, Al Amerat, Oman. Mumian has been used for centuries as traditional medicine by the local Omani people. Though commonly ingested orally to resolve a variety of common ailments, very little is known about the Mumian material in terms of its chemical composition. The principle aim of this study is to characterize the Mumian and the host rock in terms of the mineralogy and chemical characteristics using a variety of analytic instruments, including XRD, NMR, FT-IR, XRF, and UV- VIS. A secondary goal of this study …
Community Engagement Education In Academic Health Centers, Colleges, And Universities, Chyke A. Doubeni, David Nelson, Elizabeth Gross Cohn, Electra Paskett, Seleshi Ayalew Asfaw, Mehek Sumar, Syed M. Ahmed, Rhonda Mcclinton-Brown, Mark L. Wieland, Anita Kinney, Sergio Aguilar-Gaxiola, Lisa G. Rosas, Cecilia M. Patino
Community Engagement Education In Academic Health Centers, Colleges, And Universities, Chyke A. Doubeni, David Nelson, Elizabeth Gross Cohn, Electra Paskett, Seleshi Ayalew Asfaw, Mehek Sumar, Syed M. Ahmed, Rhonda Mcclinton-Brown, Mark L. Wieland, Anita Kinney, Sergio Aguilar-Gaxiola, Lisa G. Rosas, Cecilia M. Patino
Publications and Research
Community engagement (CE) is critical for advancing health equity and a key approach for promoting inclusive clinical and translational science. However, it requires a workforce trained to effectively design, implement, and evaluate health promotion and improvement strategies through meaningful collaboration with community members. This paper presents an approach for designing CE curricula for research, education, clinical care, and public health learners. A general pedagogical framework is presented to support curriculum development with the inclusion of community members as facilitators or faculty. The overall goal of the curriculum is envisioned as enabling learners to effectively demonstrate the principles of CE in …
Small Rna Signatures Of Acute Ischemic Stroke In L1cam Positive Extracellular Vesicles, Michael A Lopez, Ying Si, Xianzhen Hu, Valentyna Williams, Fuad Qushair, Jackson Carlyle, Lyndsy Alesce, Michael Conklin, Shawn Gilbert, Marcas M Bamman, Matthew S Alexander, Peter H King
Small Rna Signatures Of Acute Ischemic Stroke In L1cam Positive Extracellular Vesicles, Michael A Lopez, Ying Si, Xianzhen Hu, Valentyna Williams, Fuad Qushair, Jackson Carlyle, Lyndsy Alesce, Michael Conklin, Shawn Gilbert, Marcas M Bamman, Matthew S Alexander, Peter H King
Faculty, Staff and Student Publications
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease characterized by skeletal muscle instability, progressive muscle wasting, and fibrosis. A major driver of DMD pathology stems from aberrant upregulation of transforming growth factor β (TGFβ) signaling. In this report, we investigated the major transducers of TGFβ signaling, i.e., receptor Smads (R-Smads), in DMD patient skeletal muscle and observed a 48-fold increase in Smad8 mRNA. Smad1, Smad2, Smad3, and Smad5 mRNA were only minimally increased. A similar pattern was observed in the muscle from the mdx5cv mouse. Western blot analysis showed upregulation of phosphorylated Smad1, Smad5, and Smad8 …
Maternal Adipocyte Connexin43 Gap Junctions Affect Breastmilk Lactose Levels And Neonate Growth In Mice, Mingyang Huang, Anying Song, Xi Chen, Sarah Ishtiaq, Chunmei Wang, Darryl L Hadsell, Qiong A Wang, Yi Zhu
Maternal Adipocyte Connexin43 Gap Junctions Affect Breastmilk Lactose Levels And Neonate Growth In Mice, Mingyang Huang, Anying Song, Xi Chen, Sarah Ishtiaq, Chunmei Wang, Darryl L Hadsell, Qiong A Wang, Yi Zhu
Faculty, Staff and Students Publications
Simple Summary
Breastfeeding offers many health benefits for both mothers and infants. However, overnutrition and a steady increase in obesity in the U.S. has made it harder for many mothers to produce and express breastmilk. Moreover, the quality of breastmilk from obese mothers is frequently compromised in that it contains fewer nutrients and more inflammatory components. In this study, we used mice to model this phenomenon. We found that short-term high-fat feeding at the start of breeding reduces litter size and pups’ body weight. It also impairs adipocyte remodeling during lactation. Connexin43 is the primary building block for gap junctions …
Long-Term Follow-Up For The Development Of Subsequent Malignancies In Patients Treated With Genetically Modified Iecs, David H M Steffin, Ibrahim N Muhsen, Laquisa C Hill, Carlos A Ramos, Nabil Ahmed, Meenakshi Hegde, Tao Wang, Mengfen Wu, Stephen Gottschalk, Sarah B Whittle, Premal D Lulla, Maksim Mamonkin, Bilal Omer, Rayne H Rouce, Andras Heczey, Leonid S Metelitsa, Bambi J Grilley, Catherine Robertson, Virginia Torrano, Natalia Lapteva, Adrian P Gee, Cliona M Rooney, Malcolm K Brenner, Helen E Heslop
Long-Term Follow-Up For The Development Of Subsequent Malignancies In Patients Treated With Genetically Modified Iecs, David H M Steffin, Ibrahim N Muhsen, Laquisa C Hill, Carlos A Ramos, Nabil Ahmed, Meenakshi Hegde, Tao Wang, Mengfen Wu, Stephen Gottschalk, Sarah B Whittle, Premal D Lulla, Maksim Mamonkin, Bilal Omer, Rayne H Rouce, Andras Heczey, Leonid S Metelitsa, Bambi J Grilley, Catherine Robertson, Virginia Torrano, Natalia Lapteva, Adrian P Gee, Cliona M Rooney, Malcolm K Brenner, Helen E Heslop
Faculty, Staff and Students Publications
Subsequent malignancies are well-documented complications in long-term follow-up of cancer patients. Recently, genetically modified immune effector (IE) cells have shown benefit in hematologic malignancies and are being evaluated in clinical trials for solid tumors. Although the short-term complications of IE cells are well described, there is limited literature summarizing long-term follow-up, including subsequent malignancies. We retrospectively reviewed data from 340 patients treated across 27 investigator-initiated pediatric and adult clinical trials at our center. All patients received IE cells genetically modified with γ-retroviral vectors to treat relapsed and/or refractory hematologic or solid malignancies. In a cumulative 1027 years of long-term follow-up, …
Extracellular Domain Of Pept1 Interacts With Tm1 To Facilitate Substrate Transport, Jiemin Shen, Miaohui Hu, Xiao Fan, Zhenning Ren, Corinne Portioli, Xiuwen Yan, Mingqiang Rong, Ming Zhou
Extracellular Domain Of Pept1 Interacts With Tm1 To Facilitate Substrate Transport, Jiemin Shen, Miaohui Hu, Xiao Fan, Zhenning Ren, Corinne Portioli, Xiuwen Yan, Mingqiang Rong, Ming Zhou
Faculty, Staff and Students Publications
Mammalian peptide transporters, PepT1 and PepT2, mediate uptake of small peptides and are essential for their absorption. PepT also mediates absorption of many drugs and prodrugs to enhance their bioavailability. PepT has twelve transmembrane (TM) helices that fold into an N-terminal domain (NTD, TM1–6) and a C-terminal domain (CTD, TM7–12), and has a large extracellular domain (ECD) between TM9–10. It is well-recognized that peptide transport requires movements of the NTD and CTD, but the role of the ECD in PepT1 remains unclear. Here we report the structure of horse PepT1 encircled in lipid nanodiscs and captured in the inward-open apo …
Tp53 Copy Number And Protein Expression Inform Mutation Status Across Risk Categories In Acute Myeloid Leukemia, Mehrnoosh Tashakori, Tapan Kadia, Sanam Loghavi, Naval Daver, Rashmi Kanagal-Shamanna, Sherry Pierce, Dawen Sui, Peng Wei, Farnoosh Khodakarami, Zhenya Tang, Mark Routbort, Carol A Bivins, Elias J Jabbour, L Jeffrey Medeiros, Kapil Bhalla, Hagop M Kantarjian, Farhad Ravandi, Joseph D Khoury
Tp53 Copy Number And Protein Expression Inform Mutation Status Across Risk Categories In Acute Myeloid Leukemia, Mehrnoosh Tashakori, Tapan Kadia, Sanam Loghavi, Naval Daver, Rashmi Kanagal-Shamanna, Sherry Pierce, Dawen Sui, Peng Wei, Farnoosh Khodakarami, Zhenya Tang, Mark Routbort, Carol A Bivins, Elias J Jabbour, L Jeffrey Medeiros, Kapil Bhalla, Hagop M Kantarjian, Farhad Ravandi, Joseph D Khoury
Faculty, Staff and Student Publications
Mutant TP53 is an adverse risk factor in acute myeloid leukemia (AML), but large-scale integrated genomic-proteomic analyses of TP53 alterations in patients with AML remain limited. We analyzed TP53 mutational status, copy number (CN), and protein expression data in AML (N = 528) and provide a compilation of mutation sites and types across disease subgroups among treated and untreated patients. Our analysis shows differential hotspots in subsets of AML and uncovers novel pathogenic variants involving TP53 splice sites. In addition, we identified TP53 CN loss in 70.2% of TP53-mutated AML cases, which have more deleterious TP53 mutations, as well as …
Lncrna-Associated Genetic Etiologies Are Shared Between Type 2 Diabetes And Cancers In The Uae Population, Roberta Giordo, Rida Gulsha, Sarah Kalla, George A Calin, Leonard Lipovich
Lncrna-Associated Genetic Etiologies Are Shared Between Type 2 Diabetes And Cancers In The Uae Population, Roberta Giordo, Rida Gulsha, Sarah Kalla, George A Calin, Leonard Lipovich
Faculty, Staff and Student Publications
Numerous epidemiological studies place patients with T2D at a higher risk for cancer. Many risk factors, such as obesity, ageing, poor diet and low physical activity, are shared between T2D and cancer; however, the biological mechanisms linking the two diseases remain largely unknown. The advent of genome wide association studies (GWAS) revealed large numbers of genetic variants associated with both T2D and cancer. Most significant disease-associated variants reside in non-coding regions of the genome. Several studies show that single nucleotide polymorphisms (SNPs) at or near long non-coding RNA (lncRNA) genes may impact the susceptibility to T2D and cancer. Therefore, the …
Dissecting The Treatment-Naive Ecosystem Of Human Melanoma Brain Metastasis, Jana Biermann, Johannes C Melms, Amit Dipak Amin, Yiping Wang, Lindsay A Caprio, Alcida Karz, Somnath Tagore, Irving Barrera, Miguel A Ibarra-Arellano, Massimo Andreatta, Benjamin T Fullerton, Kristjan H Gretarsson, Varun Sahu, Vaibhav S Mangipudy, Trang T T Nguyen, Ajay Nair, Meri Rogava, Patricia Ho, Peter D Koch, Matei Banu, Nelson Humala, Aayushi Mahajan, Zachary H Walsh, Shivem B Shah, Daniel H Vaccaro, Blake Caldwell, Michael Mu, Florian Wünnemann, Margot Chazotte, Simon Berhe, Adrienne M Luoma, Joseph Driver, Matthew Ingham, Shaheer A Khan, Suthee Rapisuwon, Craig L Slingluff, Thomas Eigentler, Martin Röcken, Richard Carvajal, Michael B Atkins, Michael A Davies, Albert Agustinus, Samuel F Bakhoum, Elham Azizi, Markus Siegelin, Chao Lu, Santiago J Carmona, Hanina Hibshoosh, Antoni Ribas, Peter Canoll, Jeffrey N Bruce, Wenya Linda Bi, Praveen Agrawal, Denis Schapiro, Eva Hernando, Evan Z Macosko, Fei Chen, Gary K Schwartz, Benjamin Izar
Dissecting The Treatment-Naive Ecosystem Of Human Melanoma Brain Metastasis, Jana Biermann, Johannes C Melms, Amit Dipak Amin, Yiping Wang, Lindsay A Caprio, Alcida Karz, Somnath Tagore, Irving Barrera, Miguel A Ibarra-Arellano, Massimo Andreatta, Benjamin T Fullerton, Kristjan H Gretarsson, Varun Sahu, Vaibhav S Mangipudy, Trang T T Nguyen, Ajay Nair, Meri Rogava, Patricia Ho, Peter D Koch, Matei Banu, Nelson Humala, Aayushi Mahajan, Zachary H Walsh, Shivem B Shah, Daniel H Vaccaro, Blake Caldwell, Michael Mu, Florian Wünnemann, Margot Chazotte, Simon Berhe, Adrienne M Luoma, Joseph Driver, Matthew Ingham, Shaheer A Khan, Suthee Rapisuwon, Craig L Slingluff, Thomas Eigentler, Martin Röcken, Richard Carvajal, Michael B Atkins, Michael A Davies, Albert Agustinus, Samuel F Bakhoum, Elham Azizi, Markus Siegelin, Chao Lu, Santiago J Carmona, Hanina Hibshoosh, Antoni Ribas, Peter Canoll, Jeffrey N Bruce, Wenya Linda Bi, Praveen Agrawal, Denis Schapiro, Eva Hernando, Evan Z Macosko, Fei Chen, Gary K Schwartz, Benjamin Izar
Faculty, Staff and Student Publications
Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma; yet, our understanding of the underlying salient biology is rudimentary. Here, we performed single-cell/nucleus RNA-seq in 22 treatment-naive MBMs and 10 extracranial melanoma metastases (ECMs) and matched spatial single-cell transcriptomics and T cell receptor (TCR)-seq. Cancer cells from MBM were more chromosomally unstable, adopted a neuronal-like cell state, and enriched for spatially variably expressed metabolic pathways. Key observations were validated in independent patient cohorts, patient-derived MBM/ECM xenograft models, RNA/ATAC-seq, proteomics, and multiplexed imaging. Integrated spatial analyses revealed distinct geography of putative cancer immune evasion and evidence for more abundant …
Antibody Response To Sars-Cov-2 Vaccination In Patients With Lymphoproliferative Disorders And Plasma Cell Dyscrasias: Anti-Lymphoma Therapy As A Predictive Biomarker Of Response To Vaccination, Carol Gung, Regina Mcguire, Mercy George, Abdullateef Abdulkareem, Katherine A Belden, Pierluigi Porcu, Ubaldo Martinez-Outschoorn, Adam F Binder, Inna Chervenova, Onder Alpdogan
Antibody Response To Sars-Cov-2 Vaccination In Patients With Lymphoproliferative Disorders And Plasma Cell Dyscrasias: Anti-Lymphoma Therapy As A Predictive Biomarker Of Response To Vaccination, Carol Gung, Regina Mcguire, Mercy George, Abdullateef Abdulkareem, Katherine A Belden, Pierluigi Porcu, Ubaldo Martinez-Outschoorn, Adam F Binder, Inna Chervenova, Onder Alpdogan
Department of Medical Oncology Faculty Papers
We retrospectively analyzed SARS-CoV-2 vaccination antibody responses in a cohort of 273 patients with lymphoproliferative disorders or plasma cell dyscrasias who were seen at a single tertiary cancer center. Semi-quantitative anti-spike protein serologic testing was performed with enzyme immunoassay method. We found that the antibody response rate to SARS-CoV-2 vaccination was 74.7% in our patient cohort with no difference based on gender, age or race. The highest response rate was found in patients with Multiple Myeloma (MM) (95.5%). The response rates found in Diffuse Large B-Cell Lymphoma (DLBCL), Chronic Lymphocytic Leukemia (CLL), and Low-Grade Non-Hodgkin Lymphoma (LG-NHL) were 73.2%, 61.5% …
Biological Flora Of Coastal Wetlands: Sporobolus Cynosuroides (L.) P.M. Peterson & Saarela, Richard Stalter, Robert I. Lonard
Biological Flora Of Coastal Wetlands: Sporobolus Cynosuroides (L.) P.M. Peterson & Saarela, Richard Stalter, Robert I. Lonard
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Sporobolus cynosuroides (L.) P.M. Peterson & Saarela¼Spartina cynosuroides (L.) Roth is a temperate zone rhizomatous grass that often is a dominant species in coastal brackish marshes on the Gulf coast and Atlantic coasts of the United States where salinity ranges from 0 to 10 psu. Sporobolus cynosuroides (L.) P.M. Peterson & Saarela ¼ Spartina cynosuroides (L.) Roth is usually absent where salinity values are .12 psu. Sporobolus cynosuroides occurs in coastal habitats characterized by infrequent tidal flooding and moderate nutrient levels. Also known as big cordgrass, it may account for net productivity in high marshes that rivals productivity of Sporobolus …
Study On Pyrolysis Transfer Rules Of Seven Aglycones In Flue Gas Under Two Kinds Of Flavoring Methods, Han Lu, Chu Wen-Juan, Hu Shao-Dong, Zhao Zhi-Wei, Yang Jing, Tian Hai-Ying
Study On Pyrolysis Transfer Rules Of Seven Aglycones In Flue Gas Under Two Kinds Of Flavoring Methods, Han Lu, Chu Wen-Juan, Hu Shao-Dong, Zhao Zhi-Wei, Yang Jing, Tian Hai-Ying
Food and Machinery
bjective:The pyrolysis transfer rate of aglycones from 7 kinds of glucosides added to cigarette paper in mainstream and sidestream smoke was studied.Methods:5methylfurfuryl alcohol glucoside, menthol glucoside, anisyl alcohol glucoside, leaf alcohol glucoside, phenylethanol glucoside, ethyl vanillin glucoside and vanillin glucoside were applied to the surface of cigarette paper and inject into cigarette according to the 0.01% of the weight of cut tobacco respectively. The transfer rates of aglycones in mainstream smoke and side stream smoke were determined under two kinds of flavoring Methods. On this basis, the transfer rules of seven aglycones in mainstream smoke and sidestream …
Effects Of Breathing Tumbling On Volatile Substances Of Chinese Soy-Sauced Beef, Liu Dan-Dan, Zhao Pei, Chen Jin-Yu, Zhao Wen-Ying, Liu Zhong-Min, Wu Zi-Jian
Effects Of Breathing Tumbling On Volatile Substances Of Chinese Soy-Sauced Beef, Liu Dan-Dan, Zhao Pei, Chen Jin-Yu, Zhao Wen-Ying, Liu Zhong-Min, Wu Zi-Jian
Food and Machinery
Objective:This study aimed to improve the production technology and flavor of Chinese beef sauce.Methods:Compared with traditional static curing, the effects of breathing rolling curing on volatile components of beef were analyzed by SPME/GC-MS.Results:The main aroma components of the beef in breathing rolling and curing process were the same as those in traditional static state, which were mainly aldehydes, hydrocarbons, alcohols, esters and ketones, among which the representative substances were benzaldehyde, anisene, cineol, eugenol acetate and 2-butanone. There were some differences in the types and relative contents of volatile substances, among which the number of hydrocarbons …
Design And Test Of Head And Tail Orientation Device For Crayfish, Fu Run-Ze, Wang Ai-Ming, Chen Hong-Xing, Pan Feng-Tao, Pan Hai-Yan
Design And Test Of Head And Tail Orientation Device For Crayfish, Fu Run-Ze, Wang Ai-Ming, Chen Hong-Xing, Pan Feng-Tao, Pan Hai-Yan
Food and Machinery
Objective:To solve the difficulty of head and tail orientation in crayfish mechanized treatment.Methods:A crayfish head and tail orientation method was proposed by using the difference of crayfish head and tail shape, which was composed of a roller conveying and grading mechanism. The morphological parameters and orientation mechanism of crayfish were analyzed, then a simple head and tail orientation test device was designed and manufactured; Taking the orientation success rate (head down capture rate and tail down pass rate) as the evaluation index, the effects of capture net angle, orientation slot width and mesh size on the head …