Digital Commons Network^™

A Modern Two-Layer Hypothesis Helps Resolve The ‘Savanna Problem’, Andrew Kulmatiski, Karen H. Beard

Wildland Resources Faculty Publications

For over a century, deep roots have been assumed to allow trees to avoid competition with grasses (i.e., the two-layer hypothesis). Yet, in part because it remains difficult to measure water uptake in the field, there has been a shift in savanna ecology away from the two-layer hypothesis and towards alternative explanations of tree-grass coexistence. Here, we combine hydrologic tracer experiments and soil water flow models to demonstrate how the distribution of active roots affects water uptake across a range of savanna conditions. Grass roots were shallower and provided pre-emptive access to enough soil water to allow nearly continuous grass …

Population Genetics Of Cownose Rays, Rhinoptera Spp. In The Western Atlantic, Helen Weber

Master's Theses

Using molecular tools (e.g., the NADH subunit II mitochondrial gene), this study was the first to document the Brazilian cownose ray, Rhinoptera brasiliensis, within the northwestern Atlantic (NWA), and was the first study to examine population structure in R. brasiliensis within the NWA or northern Gulf of Mexico (GMX), revealing novel insights into the population biology of the animal and extending its range by nearly 1,500 km. This study also examined the sympatrically occurring American cownose ray, R. bonasus, and found population structure between the NWA and the GMX and the NWA and the southwestern Atlantic (SWA). High …

Adolescent Depression: Experiences And Meanings Of Being Parented And Parenting, Terri Jean Farmer

Dissertations

Major depression affects up to 40% of U.S. adolescents in mild to severe forms, compromising emotional, academic, and relational functioning, including that of interacting with parents. The purpose of this study was to explore the parent-adolescent relationship during an episode of depression in order to elucidate the adolescent experience of being parented and the parental experience as it contributes to the context of the adolescent. Research questions included: 1) What are the depressed adolescent's meanings and experiences of being parented? 2) How do the meanings and experiences of parenting contribute to the context of the lifeworld of the depressed adolescent? …

Differential Susceptibility Of Retinal Neurons To The Loss Of Mitochondrial Biogenesis Factor Nrf1, Takae Kiyama, Ching-Kang Chen, Annie Zhang, Chai-An Mao

Faculty, Staff and Student Publications

The retina, the accessible part of the central nervous system, has served as a model system to study the relationship between energy utilization and metabolite supply. When the metabolite supply cannot match the energy demand, retinal neurons are at risk of death. As the powerhouse of eukaryotic cells, mitochondria play a pivotal role in generating ATP, produce precursors for macromolecules, maintain the redox homeostasis, and function as waste management centers for various types of metabolic intermediates. Mitochondrial dysfunction has been implicated in the pathologies of a number of degenerative retinal diseases. It is well known that photoreceptors are particularly vulnerable …

Antiphospholipid Antibodies And Vitamin D Deficiency In Covid-19 Infection With And Without Venous Or Arterial Thrombosis: A Pilot Case-Control Study, Ruchi Shah, Yaqub Nadeem Mohammed, Tracy J Koehler, Jasmeet Kaur, Margarita Toufeili, Priyanjali Pulipati, Ahmed Alqaysi, Ali Khan, Mahrukh Khalid, Yi Lee, Parveen Dhillon, Anna Thao Dan, Nicholas Kumar, Monica Bowen, Anupam A Sule, Geetha Krishnamoorthy

Faculty, Staff and Student Publications

BACKGROUND: Coronavirus disease-2019 (COVID-19) is associated with thromboembolism. Antiphospholipid antibody (APLa) formation is one of the mechanisms. Vitamin D deficiency has been associated with thrombosis in antiphospholipid antibody syndrome.

OBJECTIVE: Measure APLa and vitamin D in hospitalized COVID-19 patients with and without thrombosis to evaluate if thromboembolism is associated with concomitant APLa and vitamin D deficiency.

METHODS: Case-control study. Hospitalized COVID-19 patients with a thromboembolic event (ischemic stroke, myocardial infarction, deep venous thrombosis/pulmonary embolism, Cases n = 20). Controls (n = 20): Age, sex-matched without thromboembolic events. Patients with autoimmune disorders, antiphospholipid antibody syndrome, thrombophilia, anticoagulation therapy, prior thromboembolism, chronic …

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites - Field Sampling Plan (Fsp) Bres No. 133 – Dexter Mill, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Long-Term Outcomes For Ibrutinib-Rituximab And Chemoimmunotherapy In Cll: Updated Results Of The E1912 Trial, Tait D Shanafelt, Amanda F Cashen, Et Al.

2020-Current year OA Pubs

Herein, we present the long-term follow-up of the randomized E1912 trial comparing the long-term efficacy of ibrutinib-rituximab (IR) therapy to fludarabine, cyclophosphamide, and rituximab (FCR) and describe the tolerability of continuous ibrutinib. The E1912 trial enrolled 529 treatment-naïve patients aged ≤70 years with chronic lymphocytic leukemia (CLL). Patients were randomly assigned (2:1 ratio) to receive IR or 6 cycles of FCR. With a median follow-up of 5.8 years, median progression-free survival (PFS) is superior for IR (hazard ratio [HR], 0.37; P < .001). IR improved PFS relative to FCR in patients with both immunoglobulin heavy chain variable region (IGHV) gene mutated CLL (HR: 0.27; P < .001) and IGHV unmutated CLL (HR: 0.27; P < .001). Among the 354 patients randomized to IR, 214 (60.5%) currently remain on ibrutinib. Among the 138 IR-treated patients who discontinued treatment, 37 (10.5% of patients who started IR) discontinued therapy due to disease progression or death, 77 (21.9% of patients who started IR) discontinued therapy for adverse events (AEs)/complications, and 24 (6.8% of patients who started IR) withdrew for other reasons. Progression was uncommon among patients able to remain on ibrutinib. The median time from ibrutinib discontinuation to disease progression or death among those who discontinued treatment for a reason other than progression was 25 months. Sustained improvement in overall survival (OS) was observed for patients in the IR arm (HR, 0.47; P = .018). In conclusion, IR therapy offers superior PFS relative to FCR in patients with IGHV mutated or unmutated CLL, as well as superior OS. Continuous ibrutinib therapy is tolerated beyond 5 years in the majority of CLL patients. This trial was registered at www.clinicaltrials.gov as #NCT02048813.

Contribution Of Early-Life Unpredictability To Neuropsychiatric Symptom Patterns In Adulthood, Andrea D. Spadoni, Meghan Vinograd, Bruna Cuccurazzu, Katy Torres, Laura M. Glynn, Elysia P. Davis, Tallie Z. Baram, Dewleen G. Baker, Caroline M. Nievergelt, Victoria B. Risbrough

Psychology Faculty Articles and Research

Background

Recent studies in both human and experimental animals have identified fragmented and unpredictable parental and environmental signals as a novel source of early-life adversity. Early-life unpredictability may be a fundamental developmental factor that impacts brain development, including reward and emotional memory circuits, affecting the risk for psychopathology later in life. Here, we tested the hypothesis that self-reported early-life unpredictability is associated with psychiatric symptoms in adult clinical populations.

Methods

Using the newly validated Questionnaire of Unpredictability in Childhood, we assessed early-life unpredictability in 156 trauma-exposed adults, of which 65% sought treatment for mood, anxiety, and/or posttraumatic stress disorder (PTSD) …

Ecosystem Benefits Of Adopting A Whole‐Site Approach To Mpa Management, Bede Ffinian Rowe Davies, Luke Holmes, Martin J. Attrill, Emma V. Sheehan

School of Biological and Marine Sciences

No abstract provided.

The Photoionization Dynamics, Electronic Spectroscopy, And Excited State Photochemistry Of Alco And Aloc, Vincent J. Esposito, Joseph S. Francisco

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The high cosmic abundance of carbon monoxide (CO) and the ubiquitous nature of aluminum-coated dust grains sets the stage for the production of weakly bound triatomic molecules AlCO (X ²Π) and AlOC (X ²Π) in circumstellar envelopes of evolved stars. Following desorption of cold AlCO and AlOC from the dust grain surface, incoming stellar radiation in the 2–9 eV wavelength range (visible to vacuum ultraviolet) will drive various photochemical processes. Ionization to the singlet cation state will cause an immediate Al–X (X = C, O) bond dissociation to form Al⁺ (¹S) and CO (X ^{1 …}

Subclinical Magnetic Resonance Imaging Markers Of Cerebral Small Vessel Disease In Relation To Office And Ambulatory Blood Pressure Measurements, Jesus D. Melgarejo, Gladys E. Maestre, Jose Gutierrez, Lutgarde Thijs, Luis J. Mena, Ciro Gaona, Reinier Leendertz, Joseph H. Lee, Carlos A. Chavez, Gustavo Calmon

School of Medicine Publications

Background: Twenty-four-hour and nighttime blood pressure (BP) levels are more strongly associated with cardiovascular risk than office or daytime BP measurements. However, it remains undocumented which of the office and ambulatory BP measurements have the strongest association and predictive information in relation to the presence of type I, or arteriolosclerosis type, cerebral small vessel diseases (CSVD).

Methods: A subset of 429 participants from the Maracaibo Aging Study [aged ≥40 years (women, 73.7%; mean age, 59.3 years)] underwent baseline brain magnetic resonance imaging (MRI) to visualize CSVD, which included log-transformed white matter hyperintensities (log-WMH) volume and the presence (yes/no) of lacunes, …

Triplet Therapy, Transplantation, And Maintenance Until Progression In Myeloma, Paul G Richardson, Susanna J Jacobus, Edie A Weller, Hani Hassoun, Sagar Lonial, Noopur S Raje, Eva Medvedova, Philip L Mccarthy, Edward N Libby, Peter M Voorhees, Robert Z Orlowski, Larry D Anderson, Jeffrey A Zonder, Carter P Milner, Cristina Gasparetto, Mounzer E Agha, Abdullah M Khan, David D Hurd, Krisstina Gowin, Rammurti T Kamble, Sundar Jagannath, Nitya Nathwani, Melissa Alsina, R Frank Cornell, Hamza Hashmi, Erica L Campagnaro, Astrid C Andreescu, Teresa Gentile, Michaela Liedtke, Kelly N Godby, Adam D Cohen, Thomas H Openshaw, Marcelo C Pasquini, Sergio A Giralt, Jonathan L Kaufman, Andrew J Yee, Emma Scott, Pallawi Torka, Amy Foley, Mariateresa Fulciniti, Kyle Hebert, Mehmet K Samur, Kelly Masone, Michelle E Maglio, Andrea A Zeytoonjian, Omar Nadeem, Robert L Schlossman, Jacob P Laubach, Claudia Paba-Prada, Irene M Ghobrial, Aurore Perrot, Philippe Moreau, Hervé Avet-Loiseau, Michel Attal, Kenneth C Anderson, Nikhil C Munshi, Determination Investigators

Faculty, Staff and Students Publications

BACKGROUND: In patients with newly diagnosed multiple myeloma, the effect of adding autologous stem-cell transplantation (ASCT) to triplet therapy (lenalidomide, bortezomib, and dexamethasone [RVD]), followed by lenalidomide maintenance therapy until disease progression, is unknown.

METHODS: In this phase 3 trial, adults (18 to 65 years of age) with symptomatic myeloma received one cycle of RVD. We randomly assigned these patients, in a 1:1 ratio, to receive two additional RVD cycles plus stem-cell mobilization, followed by either five additional RVD cycles (the RVD-alone group) or high-dose melphalan plus ASCT followed by two additional RVD cycles (the transplantation group). Both groups received …

Interrogating Intervention Delivery And Participants’ Emotional States To Improve Engagement And Implementation: A Realist Informed Multiple Case Study Evaluation Of Engager, Lauren Weston, Sarah Rybczynska-Bunt, Cath Quinn, Charlotte Lennox, Mike Maguire, Mark Pearson, Alex Stirzaker, Graham Durcan, Caroline Stevenson, Jonathan Graham, Lauren Carroll, Rebecca Greer, Mark Haddad, Rachael Hunter, Rob Anderson, Roxanne Todd, Sara Goodier, Sarah Brand, Susan Michie, Tim Kirkpatrick, Sarah Leonard, Tirril Harris, William Henley, Jenny Shaw, Christabel Owens, Richard Byng

Peninsula Medical School

Background

‘Engager’ is an innovative ‘through-the-gate’ complex care intervention for male prison-leavers with common mental health problems. In parallel to the randomised-controlled trial of Engager (Trial registration number: ISRCTN11707331), a set of process evaluation analyses were undertaken. This paper reports on the depth multiple case study analysis part of the process evaluation, exploring how a sub-sample of prison-leavers engaged and responded to the intervention offer of one-to-one support during their re-integration into the community. Methods

To understand intervention delivery and what response it elicited in individuals, we used a realist-informed qualitative multiple ‘case’ studies approach. We scrutinised how intervention component …

Multiracial Identity Negotiation In A “Monoracial” World, Stephanie G. Chan, Aileen R. Blomdal

Pepperdine Journal of Communication Research

The constant shift of societal values and ideals has historically left multiple individuals in utter confusion over their acceptance in certain social settings. A specific minority group that has been at the brunt of this dilemma for many years, however, are those who identify as multiracial. Mixed-race individuals have struggled to be equally accepted and appreciated for their rich cultural heritages, and with the multiple unique intercultural relationships that currently exist, these individuals are constantly dealing with niched categories, labels, and microaggressions that separate them from other minority groups. Through greater research into the brief history, the modern-day problems, and …

Security Simulations In Undergraduate Education: A Review, Joseph Simpson, Aaron Brantly

Journal of Cybersecurity Education, Research and Practice

Several decades of research in simulation and gamification in higher education shows that simulations are highly effective in improving a range of outcomes for students including declarative knowledge and interest in the topic being taught. While there appears to be a broad array of options to provide education in an undergraduate setting related to security, no previous reviews have explored computer-based simulations covering all facets of security. Given the increasing importance and adoption of interdisciplinary educational programs, it is important to take stock of simulations as a tool to broaden the range of problems, perspectives, and solutions presented to students. …

Use Of School Library Resources In Enhancing Childhood Education In Primary Schools In Idemili South Local Government Area, Anambra State, Egwuonwu Ugochi Iruoma, Osuchukwu Perpetua Ngozi Dr., Okafor Amarachi Jane

Library Philosophy and Practice (e-journal)

ABSTRACT

This study investigated the use of school library resources in enhancing Childhood education in primary schools in Idemili South Local Government Area Anambra State, Nigeria. Five research questions guided the study. A structured questionnaire and observation checklist were the instrument used in collecting data. The Descriptive survey design was used. The population of the study comprised of some selected primary schools in Idemili South local government area which according to the data collected from the state Ministry of Education, Awka. The simple random sampling technique was used to draw out the sample of five (5) primary schools from the …

July 13, 2022 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

Octopus-Inspired Adhesive Skins For Intelligent And Rapidly Switchable Underwater Adhesion, Sean T. Frey, A. B. M. Tahidul Haque, Ravi Tutika, Elizabeth V. Krotz, Chanhong Lee, Cole B. Haverkamp, Eric J. Markvicka, Michael D. Bartlett

Department of Mechanical and Materials Engineering: Faculty Publications

The octopus couples controllable adhesives with intricately embedded sensing, processing, and control to manipulate underwater objects. Current synthetic adhesive–based manipulators are typically manually operated without sensing or control and can be slow to activate and release adhesion, which limits system-level manipulation. Here, we couple switchable, octopus-inspired adhesives with embedded sensing, processing, and control for robust underwater manipulation. Adhesion strength is switched over 450× from the ON to OFF state in <50 ms over many cycles with an actively controlled membrane. Systematic design of adhesive geometry enables adherence to nonideal surfaces with low preload and independent control of adhesive strength and adhesive toughness for strong and reliable attachment and easy release. Our bio-inspired nervous system detects objects and autonomously triggers the switchable adhesives. This is implemented into a wearable glove where an array of adhesives and sensors creates a biomimetic adhesive skin to manipulate diverse underwater objects.

Leaders Of Tomorrow Make Impact Today, Sustainability Institute

Sustainability Institute Blog

No abstract provided.

Characterization Of Three-Dimensional Fractional Viscoelastic Models Through Complex Modulus Analysis And Polar Decomposition, Avradip Ghosh, Avinash Kumar Both, Chin Li Cheung

Department of Chemistry: Faculty Publications

Soft materials such as gels, elastomers, and biological tissues have diverse applications in nature and technology due to their viscoelastic nature. These soft materials often exhibit complex rheology and display elastic and viscous characteristics when undergoing deformation. In recent years, fractional calculus has emerged as a promising tool to explain the viscoelastic behavior of soft materials. Scalar constants are primarily used to quantify viscoelastic elements such as springs and dashpots. However, in three-dimensional (3D) space, not all materials show the same elastic or viscoelastic properties in all directions, especially under elastic/viscoelastic wave propagation (or anisotropy). Though previously reported studies on …

Coping Strategies For Inner Conflicts Between Gay Bear Identity And Health Concerns, Chichun Lin, Darren D. Moore

The Qualitative Report

Gay bear refers to a burly gay man with a hirsute body and face. Chinese gay bear men are highly homogeneous and strictly emphasize a uniform bear appearance; however, obesity is an obvious health issue in this population. This study aims to explore the Chinese gay bear men's inner conflicts between bear identity and health concerns. Eleven Chinese gay bear men including four Taiwanese, two mainland Chinese, two Hong Kong, two Malaysian, and one Singaporean were interviewed. The study used a thematic analysis approach and found three coping strategies including (a) Eat healthy but maintain a minimal bear standard; (b) …

Peripheral Artery Disease Affects The Function Of The Legs Of Claudicating Patients In A Diffuse Manner Irrespective Of The Segment Of The Arterial Tree Primarily Involved, Todd Leutzinger, Panagiotis Koutakis, Matthew A. Fuglestad, Hafizur Rahman, Holly Despiegelaere, Mahdi Hassan, Molly Schieber, Jason Johanning, Nick Stergiou, G. Matthew Longo, George P. Casale, Sara A. Myers, Iraklis Pipinos

Journal Articles

Different levels of arterial occlusive disease (aortoiliac, femoropopliteal, multi-level disease) can produce claudication symptoms in different leg muscle groups (buttocks, thighs, calves) in patients with peripheral artery disease (PAD). We tested the hypothesis that different locations of occlusive disease uniquely affect the muscles of PAD legs and produce distinctive patterns in the way claudicating patients walk. Ninety-seven PAD patients and 35 healthy controls were recruited. PAD patients were categorized to aortoiliac, femoropopliteal and multi-level disease groups using computerized tomographic angiography. Subjects performed walking trials both pain-free and during claudication pain and joint kinematics, kinetics, and spatiotemporal parameters were calculated to …

Assessing The Effects Of Elevation On The Peaks Of Otter Salamander (Plethodon Hubrichti) Using Body Condition Index, Norman Reichenbach, Timothy R. Brophy, Hannah Suber, Elisabeth Russell, Hannah Kinsley, Liam Cusack, Cetia Dawson, Savannah Dunn, Olivia De Araujo

Faculty Publications and Presentations

The Peaks of Otter Salamander (Plethodon hubrichti; POS) is a montane species found at elevations above 442 m within a 117 km2 area of the Blue Ridge Mountains in central Virginia. In allopatric areas (areas without the Eastern Red-backed Salamander, P. cinereus, a known competitor), POS body condition was hypothesized to decline both above and below some optimal elevation. Decreased condition at lower elevations would most likely be due to increased temperatures and lower relative humidities, which may adversely affect the ability of salamanders to forage effectively on vegetation due to desiccation risk. Decreased condition at elevations above …

Juneau's Changing Climate And Community Response, James E. Powell, Molly Tankersley, Tom Ainsworth, Jason M. Amundson, Bob Armstrong, Bruce Botelho, Richard Carstensen, David V. D'Amore, Robert James Foy, Eran Hood, Aaron Jacobs, Katie Koester, Linda Kruger, Kevin Maier, Alec Mesdag, Duff Mitchell, Sonia Nagorski, Raymond Paddock, Heidi C. Pearson, Andy Romanof, Darren Sndyer, Richard L. Thoman, Thomas F. Thornton, Peggy Wilcox

Publications

This report is designed as a living document to inform the community, decision makers, and academics and to serve as a learning and teaching tool. The nine key messages summarized on pages 6 and 7 are intended for use as a quick reference. Unique for this type of report, these key messages highlight actions by Juneau's civil society, including local nonprofit organizations.

Estimating Production Cost For Large-Scale Seaweed Farms, Hauke L. Kite-Powell, Erick Ask, Simona Augyte, David Bailey, Julie Decker, Clifford A. Goudey, Gretchen Grebe, Yoaguang Li, Scott Lindell, Domenic Manganelli, Michael Marty-Rivera, Crystal Ng, Loretta Roberson, Michael Stekoll, Schery Umanzor, Charles Yarish

Faculty, Staff, and Students

Seaweed farming has the potential to produce feedstocks for many applications, including food, feeds, fertilizers, biostimulants, and biofuels. Seaweeds have advantages over land-based biomass in that they require no freshwater inputs and no allocation of arable land. To date, seaweed farming has not been practiced at scales relevant to meaningful biofuel production. Here we describe a techno-economic model of large-scale seaweed farms and its application to the cultivation of the cool temperate species Saccharina latissima (sugar kelp) and the tropical seaweed Eucheumatopsis isiformis. At farm scales of 1000 ha or more, our model suggests that farm gate production costs in …

Juneau's Changing Climate And Community Response, James E. Powell, Molly Tankersley, Tom Ainsworth, Jason M. Amundson, Bob Armstrong, Bruce Botelho, Richard Carstensen, David V. D'Amore, Robert James Foy, Eran Hood, Aaron Jacobs, Katie Koester, Linda Kruger, Kevin Maier, Alec Mesdag, Duff Mitchell, Sonia Nagorski, Raymond Paddock, Heidi C. Pearson, Andy Romanof, Darren Sndyer, Richard L. Thoman, Thomas F. Thornton, Peggy Wilcox

Publications

This report is designed as a living document to inform the community, decision makers, and academics and to serve as a learning and teaching tool. The nine key messages summarized on pages 6 and 7 are intended for use as a quick reference. Unique for this type of report, these key messages highlight actions by Juneau's civil society, including local nonprofit organizations.

Detecting And Distinguishing Indicators Of Risk For Suicide Using Clinical Records, Brian K. Ahmedani, Cara E. Cannella, Hsueh-Han Yeh, Joslyn Westphal, Gregory E. Simon, Arne Beck, Rebecca C. Rossom, Frances L. Lynch, Christine Y. Lu, Ashli A. Owen-Smith, Kelsey J. Sala-Hamrick, Catherine Frank, Esther Akinyemi, Ganj Beebani, Christopher Busuito, Jennifer M. Boggs, Yihe G. Daida, Stephen Waring, Hongsheng Gui, Albert M. Levin

Center for Health Policy and Health Services Research Articles

Health systems are essential for suicide risk detection. Most efforts target people with mental health (MH) diagnoses, but this only represents half of the people who die by suicide. This study seeks to discover and validate health indicators of suicide death among those with, and without, MH diagnoses. This case-control study used statistical modeling with health record data on diagnoses, procedures, and encounters. The study included 3,195 individuals who died by suicide from 2000 to 2015 and 249,092 randomly selected matched controls, who were age 18+ and affiliated with nine Mental Health Research Network affiliated health systems. Of the 202 …

Antithrombin-Iii Mitigates Thrombin-Mediated Endothelial Cell Contraction And Sickle Red Blood Cell Adhesion In Microscale Flow, William J. Wulftange, Erdem Kucukal, Yuncheng Man, Ran An, Karamoja Monchamp, Charlotte D. Sevrain, Himanshu R. Dashora, Allison Bode, Jane A. Little, Umut A. Gurkan

Faculty Scholarship

Individuals with sickle cell disease (SCD) have persistently elevated thrombin generation that results in a state of systemic hypercoagulability. Antithrombin-III (ATIII), an endogenous serine protease inhibitor, inhibits several enzymes in the coagulation cascade, including thrombin. Here, we utilize a biomimetic microfluidic device to model the morphology and adhesive properties of endothelial cells (ECs) activated by thrombin and examine the efficacy of ATIII in mitigating the adhesion of SCD patient-derived red blood cells (RBCs) and EC retraction. Microfluidic devices were fabricated, seeded with ECs, and incubated under physiological shear stress. Cells were then activated with thrombin with or without an ATIII …

An Acoustofluidic Scanning Nanoscope Using Enhanced Image Stacking And Processing, Geonsoo Jin, Joseph Rich, Jianping Xia, Albert J. He, Chenglong Zhao, Tony Jun Huang

Faculty Publications

Nanoscale optical resolution with a large field of view is a critical feature for many research and industry areas, such as semiconductor fabrication, biomedical imaging, and nanoscale material identification. Several scanning microscopes have been developed to resolve the inverse relationship between the resolution and field of view; however, those scanning microscopes still rely upon fluorescence labeling and complex optical systems. To overcome these limitations, we developed a dual-camera acoustofluidic nanoscope with a seamless image merging algorithm (alpha-blending process). This design allows us to precisely image both the sample and the microspheres simultaneously and accurately track the particle path and location. …

Zero Setup Margin Mask Versus Frame Immobilization During Gamma Knife(®) Icon™ Stereotactic Radiosurgery For Brain Metastases, Tugce Kutuk, Rupesh Kotecha, Ranjini Tolakanahalli, D Jay Wieczorek, Cecilia Lee, Manmeet Ahluwalia, Matthew Hall, Michael Mcdermott, Haley Appel, Alonso Gutierrez, Minesh Mehta, Martin Tom

All Publications

We compared the clinical outcomes of BM treated with mask immobilization with zero-SM (i.e., zero-PTV) to standard zero-SM frame immobilization SRS. Consecutive patients with BM, 0.5−2.0 cm in maximal diameter, treated with single-fraction SRS (22−24 Gy) during March 2019−February 2021 were included. Univariable and multivariable analysis were performed using the Kaplan−Meier method and Cox proportional hazards regression. A total of 150 patients with 453 BM met inclusion criteria. A total of 129 (28.5%) lesions were treated with a zero-SM mask immobilization and 324 (71.5%) with zero-SM frame immobilization. Frame immobilization treatments were associated with a higher proportion of gastrointestinal and …