Digital Commons Network^™

Coupling 210Pb And 14C To Constrain Carbon Burial Efficiency Of Blue Carbon Ecosystems, Tynisha R. Martin

USF Tampa Graduate Theses and Dissertations

Blue carbon ecosystems cover a small global area but have the potential to sequester large amounts of organic carbon (OC) from the coastal ocean in the sediment. Organic carbon is continually remineralized and exported in the dissolved form, which is currently only poorly accounted for in blue carbon budgets. Constraining carbon cycling in blue carbon systems is complicated by the range of carbon sources and sinks in the system and high export rates from the system. By coupling 14C and 210Pb chronometers to ascertain the amount of primary production stored within peat, it is possible to study carbon transport through …

Publication Dynamics: What Can Be Done To Eliminate Barriers To Publishing Full Manuscripts By The Postgraduate Trainees Of A Low-Middle Income Country?, Hafsa Majid, Lena Jafri, Sibtain Ahmed, Muhammad Abbas Abid, Mohammad Aamir, Aamir Ijaz, Aysha Habib Khan, Imran Siddiqui

Department of Pathology and Laboratory Medicine

Objectives: This study aimed to determine the publication rate of free paper abstracts presented by the postgraduate (PG) trainees and determine the reasons for non-publication. A mixed methods study was conducted. PG trainees presenting free papers at the at the Pakistan Society of Chemical Pathologist conferences from 2012 to 2018 were included. Three databases were searched to identify if the abstracts were published or not. The PG trainee authors of abstracts not published as full manuscript, were surveyed to determine the barriers and challenges in publishing a manuscript.
Results: The average rate of full manuscript publication was 51.8% (n = …

Physiologically-Based Pharmacokinetics Modeling Of Colloidal Nanoparticles, Anh-Dung Le

Nanoscience and Microsystems ETDs

Physiologically-based Pharmacokinetics (PBPK) modeling—a mechanistic mathematical tool to predict biodistribution to inform drug development, requires knowledge of the physico-chemical properties of the drug in question as well as the anatomy and physiology of the organism. Unlike with molecular drugs, nanoparticle parameters often need to be estimated by fitting models to time-course data, which can result in large uncertainties in parameter estimates due to a high-dimensional parameter space. Our research addresses this challenge by offering a path to parameter insights using global sensitivity analysis. The first chapter is an overview of the PBPK model structure and mathematical framework used in our …

Identifying The Components Of A Hemp (Cannabis Sativa L.) (Rosales: Cannabaceae) Integrated Pest Management Program In Louisiana, Nathan C. Arey

LSU Master's Theses

Hemp, Cannabis sativa (L.) (Rosales: Cannabaceae), is defined as a plant in the genus Cannabis with a delta-9 3 tetrahydrocannabinol (THC) concentration of not more than 0.3% on a dry weight basis. Domestic acreage of this crop has increased in response to the ratification of the Agricultural Act of 2014 and the Agricultural Improvement Act of 2018. In 2021, 21,915 hectares of hemp were planted in the United States with a production value of $712 million. There is a current lack of literature on insect related research in this reemerging crop system in the state of Louisiana. Therefore, this present …

The Impact Of Doctor Care On Covid-19 Distrust: Results From A Random National Sample, Sidney C. Davis, Brandon C. Martinez

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

Hybrid-Control Arm Construction Using Historical Trial Data For An Early-Phase, Randomized Controlled Trial In Metastatic Colorectal Cancer, Chen Li, Katrina S Pedersen, Et Al

2020-Current year OA Pubs

Background: Treatment for metastatic colorectal cancer patients beyond the second line remains challenging, highlighting the need for early phase trials of combination therapies for patients who had disease progression during or following two prior lines of therapy. Leveraging hybrid control design in these trials may preserve the benefits of randomization while strengthening evidence by integrating historical trial data. Few examples have been established to assess the applicability of such design in supporting early phase metastatic colorectal cancer trials.

Methods: MORPHEUS-CRC is an umbrella, multicenter, open-label, phase Ib/II, randomized, controlled trial (NCT03555149), with active experimental arms ongoing. Patients enrolled were assigned …

An Updated Assessment Of 43,110 Patients Enrolled In The Childhood Cancer Research Network: A Children’S Oncology Group Report, Austin L Brown, Pagna Sok, Michael E Scheurer, Karen R Rabin, Erin L Marcotte, Douglas S Hawkins, Logan G Spector, Philip J Lupo

Center for Medical Ethics and Health Policy Staff Publications

Background: The Childhood Cancer Research Network (CCRN) was established by the Children's Oncology Group (COG) as a resource for epidemiologic studies of childhood cancer. The objective of this study was to evaluate the representativeness of CCRN and identify factors associated with enrollment.

Method: The number of US childhood patients with cancer diagnosed < 20 years of age enrolled in CCRN (2008-2015) was compared to expected counts, calculated from Surveillance, Epidemiology, and End Results incidence rates and US Census population estimates. Observed-to-expected ratios and corresponding 95% confidence intervals (CI) were estimated across sex, race, diagnosis age, calendar year, and cancer diagnosis groups. Multivariable linear regression models were generated to evaluate the association between open COG phase 3 therapeutic trials and CCRN enrollment rates.

Result: The 43,110 cases enrolled in CCRN represented 36% of the expected childhood cancers diagnosed from 2008 to 2015 (N = 120,118). CCRN enrollment ratios [95% CI] were highest among males (0.38 [95% CI, 0.37-0.38]), non-Hispanics (0.35 [95% CI, 0.35-0.36]), and those diagnosed from 1 to 4 years …

Assessment Of A Size-Based Method For Enriching Circulating Tumour Cells In Colorectal Cancer, Sai Shyam Vasantharajan, Edward Barnett, Elin S. Gray, John L. Mccall, Euan J. Rodger, Michael R. Eccles, Fran Munro, Sharon Pattison, Aniruddha Chatterjee

Research outputs 2022 to 2026

Circulating tumour cells (CTC) from solid tumours are a prerequisite for metastasis. Isolating CTCs and understanding their biology is essential for developing new clinical tests and precision oncology. Currently, CellSearch is the only FDA (U.S. Food and Drug Administration)-approved method for CTC enrichment but possesses several drawbacks owing to a reliance on the epithelial cell adhesion molecule (EpCAM) and a resource-intensive nature. Addressing these shortcomings, we optimised an existing size-based method, MetaCell, to enrich CTCs from blood of colorectal cancer (CRC) patients. We evaluated the ability of MetaCell to enrich CTCs by spiking blood with CRC cell lines and assessing …

Cellular Mechanisms Underlying State-Dependent Neural Inhibition With Magnetic Stimulation, Hui Ye, Vincent Chiun-Fan Chen, Jenna Hendee

Engineering Science Faculty Publications

Novel stimulation protocols for neuromodulation with magnetic fields are explored in clinical and laboratory settings. Recent evidence suggests that the activation state of the nervous system plays a significant role in the outcome of magnetic stimulation, but the underlying cellular and molecular mechanisms of state-dependency have not been completely investigated. We recently reported that high frequency magnetic stimulation could inhibit neural activity when the neuron was in a low active state. In this paper, we investigate state-dependent neural modulation by applying a magnetic field to single neurons, using the novel micro-coil technology. High frequency magnetic stimulation suppressed single neuron activity …

Functional Morphology And Taphonomy Of Ordovician–Silurian Diploporan Echinoderms, Stephen Ashley Hill

USF Tampa Graduate Theses and Dissertations

Diploporan echinoderms were one of the most speciose groups of stemmed echinoderms during the Ordovician. Despite this widespread abundance, the fossil record of diploporan fauna consists primarily of incomplete specimens, with complete specimens being rare. While the theca, or body, is more commonly preserved, the feeding appendages and the attachment structures (i.e. stems or holdfasts) are seldomly preserved. Insight into these features is highly valuable to the understanding the paleoecology, like the feeding and respiratory strategies, of these enigmatic creatures.

One group of diploporan echinoderms which does have an extensive fossil record, is the Holocystites Fauna, primarily known from the …

Alphafold2 And Cryoem: Revisiting Cryoem Modeling In Near-Atomic Resolution Density Maps, Corey F Hryc, Matthew L Baker

Faculty, Staff and Student Publications

With the advent of new artificial intelligence and machine learning algorithms, predictive modeling can, in some cases, produce structures on par with experimental methods. The combination of predictive modeling and experimental structure determination by electron cryomicroscopy (cryoEM) offers a tantalizing approach for producing robust atomic models of macromolecular assemblies. Here, we apply AlphaFold2 to a set of community standard data sets and compare the results with the corresponding reference maps and models. Moreover, we present three unique case studies from previously determined cryoEM density maps of viruses. Our results show that AlphaFold2 can not only produce reasonably accurate models for …

The Process Of Soil Salinization In The Irrigated Territories, T M. Khudoyberdiyev, M M. Zakirov, S Schulz, D K. Begimkulov, G E. Ochilov

Technical science and innovation

The paper studiessalinization of soils in the areas of the Syrdarya region as a result of influence human economic activities. The peculiarities of salinization problems, which was an integral part of land degradation, are considered.In general, the authors in the article "salinization of soils"are considered as a decrease or loss of biological and economic productivity of irrigated lands or areas under the influence of natural and anthropogenic factors. The object of the study was the irrigated territories of the Hungry Steppe belonging to the Syrdarya region,were there is a significant rise in groundwater of 1.5-3m and more, compared with natural …

Possible Regulation Of Toll-Like Receptor 4 By Lysine Acetylation Through Lpcat2 Activity In Raw264.7 Cells., Victory Ibigo Poloamina, Wondwossen Abate, Gyorgy Fejer, Simon K. Jackson

School of Biomedical Sciences

Inflammation is central to several diseases. TLR4 mediates inflammation by recognising and binding to bacterial lipopolysaccharides and interacting with other proteins in the TLR4 signalling pathway. Although there is extensive research on TLR4-mediated inflammation, there are gaps in understanding its mechanisms. Recently, TLR4 co-localised with LPCAT2, a lysophospholipid acetyltransferase. LPCAT2 is already known to influence lipopolysaccharide-induced inflammation; however, the mechanism of LPCAT2 influencing lipopolysaccharide-mediated inflammation is not understood. This study combined computational analysis with biochemical analysis to investigate the influence of LPCAT2 on lysine acetylation in LPS-treated RAW264.7 cells. The results suggest for the first time that LPCAT2 influences lysine …

Use Of Power-To-Gas Technology With An Excess Of Electricity In The Network, N A. Abdivakhidova

Technical science and innovation

Electricity-to-gas conversion is a key area of interest for decarbonizing and increasing the flexibility of energy systems, as it can both absorb renewable electricity during periods of excess supply and provide backup energy during periods of excess demand. By combining the power-to-gas conversion with the natural gas network, the inherent flexibility of the line package can be exploited and some of the power variability can be transferred to the gas network. Also, as long as the gas injected into the gas grid is low-carbon, such as hydrogen from renewables to gas, then the overall greenhouse gas emissions from the gas …

Increase The Nutritional Value Of Pasta With Grains And Pulses, D D. Mirkhodjaeva, E Sh Sanaev

Technical science and innovation

The main goal of this study is to develop a paste formulation containing a mixture of ginger, lemon and mint powder, as well as a combination of legumes and cereals with high nutritional value. This will expand the range of pasta. The task of achieving high quality and economic efficiency is solved by improving a number of technological processes and applying innovative methods. The effectiveness of using innovative methods of freeze-drying and microwave drying is shown in comparison with the process of drying instant pasta by frying them in vegetable oil.

Disaster Resilience Versus Ecological Resilience And The Proposed Second Causeway To South Padre Island, Juliet Vallejo, Katia Sanchez, Evelyn Roozee, Owen Temby

School of Earth, Environmental, & Marine Sciences Faculty Publications

The barrier island of South Padre is located off the coast of Texas’s southern tip in Cameron County and is a popular tourist destination with over 4 million annual visits. The only road access to and from the island is a four-lane causeway, 2.3 miles in length, that routinely experiences heavy traffic. Twenty years ago, a barge crashed into the Queen Isabella Causeway, destroying a portion of the bridge. It quickly became apparent how reliant South Padre Island (SPI) is on the causeway and raised questions regarding its lack of disaster resilience. Local boosters and government responded by proposing and …

Aryl Sulfonic Acid Catalysts: Effect Of Pendant Group Structure On Activity In Hydrolysis Of Polyethylene Terephthalate, Hossein Abedsoltan, Maria R. Coleman

Chemical and Biochemical Engineering Faculty Research & Creative Works

A series of aryl sulfonic acids were tested as catalysts for acid hydrolysis occurring at the surface of poly(ethylene) terephthalate (PET) particles. Specifically, p-toluene sulfonic acid monohydrate (PTSA), 2-naphthalenesulfonic acid (2-NSA), and 1,5-naphthalenedisulfonic acid tetrahydrate (1,5-NDSA) were chosen to provide sulfonic acid active groups and varying hydrophobic functionality. The effect of catalyst concentration and reaction temperature on PET hydrolysis rate was studied. The aryl sulfonic acid catalysts exhibited much higher rates of PET hydrolysis than the mineral acid, H₂SO₄. At 150°C and 4 M catalyst, the time required to achieve more than 90% TPA yield was …

College Students’ Adoption Of Sonocent, A Specialized Notetaking Software: A Descriptive Study, Marie-Christine Potvin, Monique Chabot, Richard Hass, Abigail Garrity, Anne Bower

Department of Occupational Therapy Faculty Papers

Notetaking is critical to students’ academic success. Students have many notetaking software programs to available for support. This study aimed to describe college students’ adoption and use of a comprehensive notetaking software (Sonocent). Freshman students (n=138) were offered a free Sonocent license with free training on its use during first semester science coursework. The study found a small adoption rate among participants and an overall low level of satisfaction with the software. Students who reported difficulty with notetaking at the start of the semester were more likely to use Sonocent with the audio recording feature deemed most useful.

The Origin Of Bladder Cancer From Mucosal Field Effects, Jolanta Bondaruk, Roman Jaksik, Ziqiao Wang, David Cogdell, Sangkyou Lee, Yujie Chen, Khanh Ngoc Dinh, Tadeusz Majewski, Li Zhang, Shaolong Cao, Feng Tian, Hui Yao, Paweł Kuś, Huiqin Chen, John N Weinstein, Neema Navai, Colin Dinney, Jianjun Gao, Dan Theodorescu, Christopher Logothetis, Charles C Guo, Wenyi Wang, David Mcconkey, Peng Wei, Marek Kimmel, Bogdan Czerniak

Faculty, Staff and Student Publications

Whole-organ mapping was used to study molecular changes in the evolution of bladder cancer from field effects. We identified more than 100 dysregulated pathways, involving immunity, differentiation, and transformation, as initiators of carcinogenesis. Dysregulation of interleukins signified the involvement of inflammation in the incipient phases of the process. An aberrant methylation/expression of multiple HOX genes signified dysregulation of the differentiation program. We identified three types of mutations based on their geographic distribution. The most common were mutations restricted to individual mucosal samples that targeted uroprogenitor cells. Two types of mutations were associated with clonal expansion and involved large areas of …

Kras Mutations As Essential Promoters Of Lymphangiogenesis Via Extracellular Vesicles In Pancreatic Cancer, Radu Pirlog, George A Calin

Faculty, Staff and Student Publications

Kirsten rat sarcoma virus (KRAS) gene mutations are present in more than 90% of pancreatic ductal adenocarcinomas (PDACs). KRASG12D is the most frequent alteration, promoting preneoplastic lesions and associating with a more aggressive phenotype. These tumors possess increased intratumoral lymphatic networks and frequent lymph node (LN) metastases. In this issue of the JCI, Luo, Li, et al. explored the relationship between the presence of the KRASG12D mutation and lymphangiogenesis in PDAC. The authors used in vitro and in vivo models and an elegant mechanistic approach to describe an alternative pathway for lymphangiogenesis promotion. KRASG12D induced SUMOylation of heterogenous nuclear ribonucleoprotein …

Cd11b Suppresses Tlr Activation Of Nonclassical Monocytes To Reduce Primary Graft Dysfunction After Lung Transplantation, Melissa Querrey, Stephen Chiu, Emilia Lecuona, Qiang Wu, Haiying Sun, Megan Anderson, Megan Kelly, Sowmya Ravi, Alexander V. Misharin, Daniel Kreisel, Ankit Bharat, G. R. Scott Budinger

2020-Current year OA Pubs

Primary graft dysfunction (PGD) is the leading cause of postoperative mortality in lung transplant recipients and the most important risk factor for development of chronic lung allograft dysfunction. The mechanistic basis for the variability in the incidence and severity of PGD between lung transplant recipients is not known. Using a murine orthotopic vascularized lung transplant model, we found that redundant activation of Toll-like receptors 2 and 4 (TLR2 and -4) on nonclassical monocytes activates MyD88, inducing the release of the neutrophil attractant chemokine CXCL2. Deletion of Itgam (encodes CD11b) in nonclassical monocytes enhanced their production of CXCL2 and worsened PGD, …

Un-Earthing Popular Climate Narratives: Maintenance And Prophecy In Settler World, Hannah Oxford

Communication ETDs

Climate change is fundamentally rooted in facts such as rising global temperatures, carbon emissions, losses in biodiversity, etc. However new information about our changing world is translated and incorporated within the narratives we live by and give form to our personal and collective worlds. While climate change is scientific, our mitigation efforts are entirely storied. This thesis looks at popular climate narratives that frames climate change as an issue of Earthly mechanics fixable through innovative technology. The goal of this thesis is to understand the ways in which settler colonialism, as a communicable mechanism of cultural production, organizes this particular …

Distribution And Transport Of Microplastics In Groundwater (Shiraz Aquifer, Southwest Iran), Atefeh Esfandiari, Sajjad Abbasi, Ahmad Behrouj Peely, Dariush Mowla, Mohammad Ali Ghanbarian, Patryk Oleszczuk, Andrew Turner

School of Geography, Earth and Environmental Sciences

Despite the significance of groundwater to the hydrological cycle and as a source of potable water, very little information exists on microplastics (MPs) in this environment. In the present study, MPs have been determined in ten well samples obtained from an alluvial aquifer in a semi-arid region (Shiraz, Iran) following filtration, digestion and inspection under a binocular microscope. A total of 96 MPs were identified, and concentrations ranged from 0.1 to 1.3 MP L−1 (mean and median = 0.48 and 0.43 MP L−1, respectively) and exhibited a complex distribution across the area that reflected differences in land use and local …

Neuronal Activity Induces Glucosylceramide That Is Secreted Via Exosomes For Lysosomal Degradation In Glia, Liping Wang, Guang Lin, Zhongyuan Zuo, Yarong Li, Seul Kee Byeon, Akhilesh Pandey, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

Recessive variants in GBA1 cause Gaucher disease, a prevalent form of lysosome storage disease. GBA1 encodes a lysosomal enzyme that hydrolyzes glucosylceramide (GlcCer) into glucose and ceramide. Its loss causes lysosomal dysfunction and increased levels of GlcCer. We generated a null allele of the Drosophila ortholog Gba1b by inserting the Gal4 using CRISPR-Cas9. Here, we show that Gba1b is expressed in glia but not in neurons. Glial-specific knockdown recapitulates the defects found in Gba1b mutants, and these can be rescued by glial expression of human GBA1. We show that GlcCer is synthesized upon neuronal activity, and it is transported …

Impact Of The Salt Concentration And Biophysical Cohesion On The Settling Behavior Of Bentonites, E Krahl, B Vowinckel, L Ye, T-J Hsu, Aj Manning

School of Biological and Marine Sciences

The flocculation behavior of clay minerals in aquatic environments is an important process in estuarine and riverine dynamics, where strong gradients in salinity can locally occur. Various contradicting observations have been reported in the literature on the impact of salt concentration on the settling process of cohesive sediments. To address this issue in a systematic manner, we investigate the settling behavior of clay minerals as a function of the salt concentration of the ambient water. Specifically, we focus on montmorillonite as a prototype clay mineral with a high cation exchange capacity (CEC). To this end, we study suspensions of Wyoming …

Determining The 3d Structure And Dynamics Of Mouse Notch1 Epidermal Growth Factor-Like Repeat 26 Using Nuclear Magnetic Resonance Spectroscopy, Kendra D. Jenkins

LSU Doctoral Dissertations

NOTCH is a transmembrane protein that transmits signals between cells in direct contact and alters gene expression. The signaling pathway is important because it is involved in cell fate determination. The NOTCH1 extracellular domain has 36 epidermal growth factor-like (EGF) repeats that are responsible for ligand binding. Mutations in the EGF-like repeats cause various neurological and developmental disorders. NOTCH1 signaling initiates when DSL ligands bind to EGF11-12, the minimum Ligand Binding Domain (LBD). The Abruptex region of the NOTCH1 protein (EGF24-29) is a highly glycosylated, flexible region with calcium binding sites that regulates NOTCH1 signaling and binding by interacting with …

The Role Of Natural Products And Their Multitargeted Approach To Treat Solid Cancer, Naoshad Muhammad, Darksha Usmani, Mohammad Tarique, Huma Naz, Mohammad Ashraf, Ramesh Raliya, Shams Tabrez, Torki A Zughaibi, Ahdab Alsaieedi, Israa J Hakeem, Mohd Suhail

2020-Current year OA Pubs

Natural products play a critical role in the discovery and development of numerous drugs for the treatment of various types of cancer. These phytochemicals have demonstrated anti-carcinogenic properties by interfering with the initiation, development, and progression of cancer through altering various mechanisms such as cellular proliferation, differentiation, apoptosis, angiogenesis, and metastasis. Treating multifactorial diseases, such as cancer with agents targeting a single target, might lead to limited success and, in many cases, unsatisfactory outcomes. Various epidemiological studies have shown that the steady consumption of fruits and vegetables is intensely associated with a reduced risk of cancer. Since ancient period, plants, …

Identification And Verification Of Potential Biomarkers In Gastric Cancer By Integrated Bioinformatic Analysis, Chenyu Sun, Yue Chen, Na Hyun Kim, Scott Lowe, Shaodi Ma, Zhen Zhou, Rachel Bentley, Yi-Sheng Chen, Margaret Whitaker Tuason, Wenchao Gu, Chandur Bhan, John Pocholo W. Tuason, Pratikshya Thapa, Ce Cheng, Qin Zhou, Yanzhe Zhu

Student Publications

Background: Gastric cancer (GC) is a common cancer with high mortality. This study aimed to identify its differentially expressed genes (DEGs) using bioinformatics methods.

Methods: DEGs were screened from four GEO (Gene Expression Omnibus) gene expression profiles. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. A protein-protein interaction (PPI) network was constructed. Expression and prognosis were assessed. Meta-analysis was conducted to further validate prognosis. The receiver operating characteristic curve (ROC) was analyzed to identify diagnostic markers, and a nomogram was developed. Exploration of drugs and immune cell infiltration analysis were conducted.

Results: Nine up-regulated …

Emerging Roles And Potential Applications Of Non-Coding Rnas In Cervical Cancer, Deepak Parashar, Anupam Singh, Saurabh Gupta, Aishwarya Sharma, Manish K. Sharma, Kuldeep K. Roy, Subhash Chauhan, Vivek K. Kashyap

School of Medicine Publications

Cervical cancer (CC) is a preventable disease using proven interventions, specifically prophylactic vaccination, pervasive disease screening, and treatment, but it is still the most frequently diagnosed cancer in women worldwide. Patients with advanced or metastatic CC have a very dismal prognosis and current therapeutic options are very limited. Therefore, understanding the mechanism of metastasis and discovering new therapeutic targets are crucial. New sequencing tools have given a full visualization of the human transcriptome’s composition. Non-coding RNAs (NcRNAs) perform various functions in transcriptional, translational, and post-translational processes through their interactions with proteins, RNA, and even DNA. It has been suggested that …

Lessons From Bright-Spots For Advancing Knowledge Exchange At The Interface Of Marine Science And Policy, Denis B. Karcher, Christopher Cvitanovic, Putten Ie Van, Rebecca M. Colvin, Derek Armitage, Shankar Aswani, Marta Ballesteros, Natalie C. Ban, María José Barragán-Paladines, Angela Bednarek, Johann D. Bell, Cassandra M. Brooks, Tim M. Daw, La Cruz-Modino R De, Tessa B. Francis, Elizabeth A. Fulton, Alistair J. Hobday, Draško Holcer, Charlotte Hudson, Tim C. Jennerjahn, Aimee Kinney, Maaike Knol-Kauffman, Marie F. Löf, Priscila F.M. Lopes, Peter C. Mackelworth, Abigail Mcquatters-Gollop, Ella Kari Muhl, Pita Neihapi, José J. Pascual-Fernández, Stephen M. Posner, Hens Runhaar, Keith Sainsbury, Gunnar Sander, Dirk J. Steenbergen, Paul M. Tuda, Elizabeth Whiteman, Jialin Zhang

School of Biological and Marine Sciences

Evidence-informed decision-making is in increasing demand given growing pressures on marine environments. A way to facilitate this is by knowledge exchange among marine scientists and decision-makers. While many barriers are reported in the literature, there are also examples whereby research has successfully informed marine decision-making (i.e., ‘bright-spots’). Here, we identify and analyze 25 bright-spots from a wide range of marine fields, contexts, and locations to provide insights into how to improve knowledge exchange at the interface of marine science and policy. Through qualitative surveys we investigate what initiated the bright-spots, their goals, and approaches to knowledge exchange. We also seek …