Digital Commons Network^™

A New Comprehensive Dimensionless Inflow Performance Relationship For Gas Wells, Azim Kalantariasl, Isa Farhadi, Soosan Farzani, Alireza Keshavarz

Research outputs 2022 to 2026

Prediction of gas well deliverability is important for reservoir management. Conventional flow after flow, isochronal or modified isochronal tests are common methods for calculation of well deliverability. Single-point test using Vogel-type dimensionless inflow performance relationships (IPR) was also proposed to overcome the need for multi-point tests. However, analysis of field data showed that existing dimensionless IPR correlations fail to accurately predict well deliverability for some reservoir conditions. In this study, a wide range of reservoir rock and fluid data was used to develop a comprehensive dimensionless IPR correlation for calculation of gas well deliverability from single-point test data. Multi-point well …

Elastic Tubes: The Ideal Equipment For Telehealth Exercise Medicine In The Management Of Prostate Cancer?, Georgios Mavropalias

Research outputs 2022 to 2026

Prostate cancer (PCa) affects 1 in 8 men, but exercise therapy has been shown to be a very effective intervention not only to induce physiological benefits but to also reduce the side effects of cancer treatments typically administered during PCa. The COVID19 pandemic has restricted access to exercise clinics, a problem which always existed for people living in rural and remote areas. This caused many exercise physiologists and researchers to transition their clinic-based exercise to online, home-based exercise. We would like to propose that researchers and exercise physiologists should consider the use of elastic tubes in both research and the …

Contributing Factors Of Dui Recidivism Among First-Time Offenders In North Dakota, Yun Zhou

Transportation Logistics and Finance

This study explored utilizing tree-based machine learning models to identify associations in a range of 107 factors and DUI recidivism among first-time DUI offenders. Three tree-based machine learning models, Decision Tree, Random Forest, and Gradient Boosting were performed on 12,879 first-time DUI offenders during 2013-2017 using a three-year following period, to classify repeat DUI offenders. Study cohorts include 11,651 drivers without recidivism and 1,228 drivers with recidivism. The models tested 107 variables/predictors, including the driver’s demographic factors, drinking behaviors, traffic violations, crash histories, DUI-related violations, social-economic factors, and health and safety factors based on the driver’s residence. oversampling technique was …

Hydrogen Diffusion In Coal: Implications For Hydrogen Geo‐Storage, Alireza Keshavarz, Hussein R. Abid, Muhammad Ali, Sefan Iglauer

Research outputs 2014 to 2021

Hypothesis

Hydrogen geo-storage is considered as an option for large scale hydrogen storage in a full-scale hydrogen economy. Among different types of subsurface formations, coal seams look to be one of the best suitable options as coal’s micro/nano pore structure can adsorb a huge amount of gas (e.g. hydrogen) which can be withdrawn again once needed. However, literature lacks fundamental data regarding H₂ diffusion in coal.

Experiments

In this study, we measured H₂ adsorption rate in an Australian anthracite coal sample at isothermal conditions for four different temperatures (20 °C, 30 °C, 45 °C and 60 °C), at …

Fatality Risk Management: Applying Quinlan’S Ten Pathways In Western Australia’S Mining Industry, Tanya Jenke, Jessica L. Boylan, Shelley Beatty, Martin Ralph, Andrew Chaplyn, Greg Penney, Marcus Cattani

Research outputs 2014 to 2021

In ‘Ten Pathways to Death and Disaster’ Professor Michael Quinlan (2014) identified a series of ten common catastrophic incident risk factors, known as the Ten Pathways, contributing to major incidents in mining and other high hazard industries. This study applies the Quinlan methodology in two separate phases. The first phase of the study explored employee perception of employer effectiveness of fatality prevention against each of the Ten Pathways through a questionnaire of n = 2009 participants at the 2017–2019 Western Australian Government Mines Safety Roadshows. Respondents generally perceived their employer as having a relatively good understanding of the role of …

Digging For Data: How Sleep Is Losing Out To Roster Design, Sleep Disorders, And Lifestyle Factors, Gemma Maisey, Marcus Cattani, Amanda Devine, Johnny Lo, Shih Ching Fu, Ian C. Dunican

Research outputs 2014 to 2021

Shift workers employed at a remote mining operation may experience sleep loss, impaired alertness, and consequently negative health and safety outcomes. This study determined the sleep behaviors and prevalence of risk for sleep disorders among shift workers; and quantified alertness for a roster cycle. Sleep duration was significantly less following; night shift by 77 ± 7 min and day shift by 30 ± 7 min. The wake after sleep onset was less by 23 ± 3 min for night shifts and 22 ± 3 min for day shifts (p < 0.05 for all). The prevalence of risk for sleep apnea was 31%, insomnia was 8%, and shiftwork disorder was 44%. Average alertness for all working hours was 75%. Shiftwork in remote mining operations is a significant factor that leads to sleep loss and reduced alertness, which is exacerbated by the high prevalence of risk for sleep disorders.

Factors Influencing The Development And Implementation Of Nurse Practitioner Candidacy Programs: A Scoping Review, Lisa Whitehead, Diane E. Twigg, Rebecca Carman, Courtney Glass, Helena Halton, Christine M. Duffield

Research outputs 2014 to 2021

Background

To meet the growing needs of a diverse population, it is critical that healthcare service provision is underpinned by innovative, cost-effective, and sustainable services and solutions. The role of the nurse practitioner creates an opportunity to meet the increasing demands of complex care and enables greater access to high quality care. Understanding how best to support nurse practitioner candidates to develop into the nurse practitioner role will create greater opportunities to transform service delivery and improve healthcare outcomes.

Aim

To identify key factors that support and positively impact the implementation of nurse practitioner candidacy programs and candidate experiences.

Methods …

Patients’ Experiences Of A Communication Enhanced Environment Model On An Acute/Slow Stream Rehabilitation And A Rehabilitation Ward Following Stroke: A Qualitative Description Approach, Sarah D'Souza, Deborah J. Hersh, Erin Godecke, Natalie Ciccone, Heidi Janssen, Elizabeth Armstrong

Research outputs 2014 to 2021

Background

Patients in hospital following stroke express a desire to continue therapy tasks outside of treatment activities. However, they commonly describe experiences of boredom and inactivity. An enriched environment aims to provide opportunities for physical, cognitive and social activity and informed the development of a Communication Enhanced Environment (CEE) model to promote patient engagement in language activities.

Purpose

Explore patient perceptions of a CEE model, and barriers and facilitators to engagement in the model.

Methods

A qualitative description study from a larger project that implemented a CEE model into acute and rehabilitation private hospital wards in Western Australia. Semi-structured interviews …

Protocol For The Development Of The International Population Registry For Aphasia After Stroke (I-Praise), M. Ali, A. L. Ben Basat, M. Berthier, M. B. Johansson, C. Breitenstein, D. A. Cadilhac, F. Constantinidou, M. Cruice, G. Davila, M. Gandolfi, M. Gil, R. Grima, Erin Godecke, L. Jesus, L. M. Jiminez, M. Kambanaros, T. Kukkonen, A. Laska, I. Mavis, R. Mc Menamin, C. Mendez-Orellana, H. Obrig, P. Ostberg, H. Robson, K. Sage, M. Van De Sandt-Koenderman, K. Sprecht, E. Visch-Brink, E. Wehling, S. Wielaert, S. J. Wallace, L. J. Williams, M. C. Brady

Research outputs 2014 to 2021

Background: We require high-quality information on the current burden, the types of therapy and resources available, methods of delivery, care pathways and long-term outcomes for people with aphasia. Aim: To document and inform international delivery of post-stroke aphasia treatment, to optimise recovery and reintegration of people with aphasia. Methods & Procedures: Multi-centre, prospective, non-randomised, open study, employing blinded outcome assessment, where appropriate, including people with post-stroke aphasia, able to attend for 30 minutes during the initial language assessment, at first contact with a speech and language therapist for assessment of aphasia at participating sites. There is no study-mandated intervention. Assessments …

Independent And Interactive Associations Of Dietary Nitrate And Salt Intake With Blood Pressure And Cognitive Function: A Cross-Sectional Analysis In The Inchianti Study, Andrea M. Mcgrattan, Blossom C. M. Stephan, Oliver M. Shannon, Mohsen Mazidi, Mark Gilchrist, Miranda Smallwood, Paul Winyard, Nicholas Mcmahon, Lauren C. Blekkenhorst, Devi Mohan, Stefania Bandinelli, Louise Robinson, Luigi Ferrucci, Mario Siervo

Research outputs 2014 to 2021

Blood pressure (BP) control is a key target for interventions to reduce cognitive decline. This cross-sectional study explored associations between objective (24-hour urine excretion) and subjective (food frequency questionnaire [FFQ]) measures of dietary sodium and nitrate intakes with cognitive function and resting BP in the InCHIANTI cohort. Baseline data from 989 participants aged >50 years were included. In fully adjusted models, participants with concurrent high nitrate and low sodium (Odds Ratio (OR)=0.49, 95%CI 0.32–0.76, p = 0.001) and high nitrate and high sodium (OR = 0.49, 95%CI 0.32–0.77, p = 0.002) 24-hour urinary concentrations had lower odds of high BP …

The Use Of Complementary Medicine During Childbearing Years: A Multi-Country Study Of Women From The Middle East, Diana Arabiat, Lisa Whitehead, Samia Gaballah, Nazi Nejat, Ebtehal Galal, Eman Abu Sabah, Nazek Smadi, Inas Saadeh, Randa Khlaif

Research outputs 2014 to 2021

The prevalence of self-prescribed complementary medicine (CM) use is an area of concern across the Middle East. We conducted a descriptive qualitative study to describe women’s use of CM during their childbearing years in Egypt, Jordan, Saudi Arabia and Iran. The study conducted using face to face audio-recorded interviews with 70 participants. Our findings showed that women used several herbal plants to ease pain and discomfort during menstruation and/or during pregnancy and in postpartum care. Acupuncture, meditation, and massage were less likely to be used by women. The impact of CM was often described in relation to perceived usefulness and …

Myokine Expression And Tumor-Suppressive Effect Of Serum Following 12 Weeks Of Exercise In Prostate Cancer Patients On Adt, Jin-Soo Kim, Rebekah Louise Wilson, Dennis Taaffe, Daniel A. Galvao, Elin S. Gray, Robert Newton

Research outputs 2014 to 2021

Purpose:

Although several mechanisms have been proposed for the tumor-suppressive effect of exercise, little attention has been given to myokines, even though skeletal muscle is heavily recruited during exercise resulting in myokine surges. We measured resting serum myokine levels before and after an exercise-based intervention and the effect of this serum on prostate cancer cell growth.

Methods:

Ten prostate cancer patients undertaking androgen deprivation therapy (age, 73.3 ± 5.6 yr) undertook a 12-wk exercise-based intervention including supervised resistance training, self-directed aerobic exercise, and protein supplementation. Body composition was assessed by dual-energy x-ray absorptiometry and muscle strength by the one-repetition maximum …

The Association Between An Energy-Adjusted Dietary Inflammatory Index And Inflammation In Rural And Urban Black South Africans, Maylene Ferreira, H. Toinét Cronjé, Tertia Van Zyl, Nicola P. Bondonno, Marlien Pieters

Research outputs 2014 to 2021

Objective:

To quantify the inflammatory potential of the diet of rural and urban Black South Africans using an adapted energy-adjusted dietary inflammatory index (AE-DII) and to investigate its relationship with inflammatory and cardio-metabolic disease risk markers. Dietary inflammatory potential has not been investigated in African populations.

Design:

Cross-sectional investigation.

Setting:

Rural and urban sites in the North West province of South Africa.

Participants:

1,885 randomly selected, apparently healthy Black South Africans older than 30 years.

Results:

AE-DII scores ranged from -3.71 to +5.08 with a mean of +0.37. AE-DII scores were significantly higher in men (0.47±1.19) than in women (0.32±1.29), …

Understanding, Promoting And Supporting Lgbtqi+ Diversity In Legal Education, Aidan Ricciardo, Shane L. Rogers, Stephen D. Puttick, Natalie Skead, Stella Tarrant, Melville Thomas

Research outputs 2014 to 2021

Australian law schools are becoming increasingly diverse. Yet, there is very little quantitative or qualitative data on diversity in law schools and even less research examining how students’ diverse backgrounds and social identities–including their sexual orientation and gender identity–affect their law student experience. This article begins to fill this gap in the literature by reporting the findings from a study examining the law school experiences of LGBTQI+ students at all law schools within a single Australian state. The study reveals that much of the law school experience is similar for both LGBTQI+ and non-LGBTQI+ students, and that LGBTQI+ law students …

Identifying Key Elements To Assess Patient’S Acceptability Of Neurorehabilitation In Stroke Survivors–A Delphi Method, Manonita Ghosh, Kaoru Nosaka, Lisa Whitehead, Kazunori Nosaka

Research outputs 2014 to 2021

Purpose: Assessing patient acceptability of treatment is a clinical concern. No guidance exists to determine the best way to measure acceptability in stroke neurorehabilitation. This study identifies key elements to measure patient’s acceptance of stroke neurorehabilitation by establishing expert consensus.

>Materials and methods: A four-phase Delphi method with a three-round electronic-based survey was conducted. Experts were considered as stroke survivors or their caregivers and professionals in stroke neurorehabilitation. A twenty-five-item list was sourced from a literature review and discussion with a consumer panel (n = 22). In Round-1 (n = 118) and Round-2 (n = 80), experts …

Performing Kayepa Dordok Living Waters In Noongar Boodjar, South-Western Australia, Clint Bracknell, Pierre Horwitz, Trevor Ryan, Jonathan W. Marshall

Research outputs 2014 to 2021

Performance through language, song and dance provides alternative knowledges and ways of understanding, in this case, developing deeper relationships with living water. Drawing on Indigenous Noongar culture from south-western Australia, this paper addresses the question: How can relationships between living underground, estuarine and riverine water bodies (kayepa dordok) be performed? Two new interlinked Noongar works in response to local riverscapes were developed for, and performed as part of, the 2021 Perth Festival. The first was to embody the return journey of the bullshark, from the salt water to the riverine fresh water; the second was to enact the …

Utilising A Systematic Review-Based Approach To Create A Database Of Individual Participant Data For Meta- And Network Meta-Analyses: The Release Database Of Aphasia After Stroke, Louise R. Williams, Myzoon Ali, Kathryn Vandenberg, Linda J. Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A. Copland, Tamara B. Cranfill, Marie Di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis M T Jesus, Maria Kambanaros, Eun K. Kang, Eman M. Khedr, Anthony P H Kong, Tarja Kukkonen, Marina Laganaro, Matthew A. Lambon Ralph, Ann C. Laska, Béatrice Leemann, Alexander P. Leff, Roxele R. Lima, Antje Lorenz, Brian Macwhinney, Rebecca S. Marshall, Flavia Mattioli, İlknur Maviş, Marcus Meinzer, Reza Nilipour, Enrique Noé, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida F. Patricio, Isabel P. Martins, Cathy Price, Tatjana P. Jakovac, Elizabeth Rochon, Miranda L. Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B. Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P. Szaflarski, Shirley A. Thomas, Mieke Van De Sandt-Koenderman, Ineke Van Der Meulen, Evy Visch-Brink, Linda Worrall, Heather H. Wright, Marian C. Brady, The Release Collaborators

Research outputs 2014 to 2021

Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned …

Does Government Efficiency Mitigate The Effect Of Natural Disasters On Tourist Arrivals, Yang Yang, Songshan (Sam) Huang, Wei Li, Fangyu Zhong, Tian Lan

Research outputs 2014 to 2021

Global tourism suffered its worst year in 2020 due to the widespread of COVID-19, and tourism industry-related professionals are looking for efficient measures to help tourism recover. Government efficiency was mentioned as an important factor for inbound tourism; however, its mitigating effect on the performance of inbound tourism in the context of natural disasters has not been empirically researched. This study attempts to address the gap through the analysis of a panel data set of 158 countries from 2002 to 2018. The results illustrate the mitigating effect of government efficiency on the negative impact of natural disasters on inbound tourist …

Detection Of Clinical Progression Through Plasma Ctdna In Metastatic Melanoma Patients: A Comparison To Radiological Progression, Gabriela Marsavela, Ashleigh C. Mcevoy, Michelle R. Pereira, Anna L. Reid, Zeyad Al-Ogaili, Lydia Warburton, Muhammad K. Khattak, Afaf Abed, Tarek M. Meniawy, Michael Millward, Melanie R. Ziman Dr, Leslie Calapre, Elin S. Gray

Research outputs 2014 to 2021

Background

The validity of circulating tumour DNA (ctDNA) as an indicator of disease progression compared to medical imaging in patients with metastatic melanoma requires detailed evaluation.

Methods

Here, we carried out a retrospective ctDNA analysis of 108 plasma samples collected at the time of disease progression. We also analysed a validation cohort of 66 metastatic melanoma patients monitored prospectively after response to systemic therapy.

Results

ctDNA was detected in 62% of patients at the time of disease progression. For 67 patients that responded to treatment, the mean ctDNA level at progressive disease was significantly higher than at the time of …

Associations Of Fat And Muscle Mass With Overall Survival In Men With Prostate Cancer: A Systematic Review With Meta-Analysis, Pedro Lopez, Robert U. Newton, Dennis R. Taaffe, Favil Singh, Laurien M. Buffart, Nigel Spry, Colin Tang, Fred Saad, Daniel A. Galvao

Research outputs 2014 to 2021

Background

To systematically review and analyse the associations between fat and muscle mass measures with overall survival in men with prostate cancer.

Methods

A systematic search was conducted in CINAHL, Cochrane Library, EMBASE, PubMed, and Web of Science databases from inception to December 2020, while abstracts from the American Society of Clinical Oncology (ASCO), Clinical Oncology Society of Australia (COSA), and the American College of Sports Medicine (ACSM) conferences were searched from 2014 to 2020. Eligible articles examined the association of body composition measures, such as fat mass (e.g., fat mass, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and …

Implementation Barriers To Integrating Exercise As Medicine In Oncology: An Ecological Scoping Review, Mary A. Kennedy, Sara Bayes, Robert U. Newton, Yvonne Zissiadis, Nigel Spry, Dennis Taaffe, Nicolas H. Hart, Daniel A. Galvao

Research outputs 2014 to 2021

Purpose

While calls have been made for exercise to become standard practice in oncology, barriers to implementation in real-world settings are not well described. This systematic scoping review aimed to comprehensively describe barriers impeding integration of exercise into routine oncology care within healthcare systems.

Methods

A systematic literature search was conducted across six electronic databases (since 2010) to identify barriers to implementing exercise into real-world settings. An ecological framework was used to classify barriers according to their respective level within the healthcare system.

Results

A total of 1,376 results were retrieved; 50 articles describing implementation barriers in real-world exercise oncology …

Exploring Specific Predictors Of Psychosis Onset Over A 2-Year Period: A Decision-Tree Model, Jone Bjornestad, Tore Tjora, Johannes H. Langeveld, Helen J. Stain, Inge Joa, Jan Olav Johannessen, Michelle Friedman-Yakoobian, Wenche Ten Velden Hegelstad

Research outputs 2014 to 2021

Aim: The fluctuating symptoms of clinical high risk for psychosis hamper conversion prediction models. Exploring specific symptoms using machine-learning has proven fruitful in accommodating this challenge. The aim of this study is to explore specific predictors and generate atheoretical hypotheses of onset using a close-monitoring, machine-learning approach. Methods: Study participants, N = 96, mean age 16.55 years, male to female ratio 46:54%, were recruited from the Prevention of Psychosis Study in Rogaland, Norway. Participants were assessed using the Structured Interview for Psychosis Risk Syndromes (SIPS) at 13 separate assessment time points across 2 years, yielding 247 specific scores. A machine-learning …

A Phylogeny Of Antirrhinum Reveals Parallel Evolution Of Alpine Morphology, Mario Durán-Castillo, Andrew Hudson, Yvette Wilson, David L. Field, Alex D. Twyford

Research outputs 2014 to 2021

Parallel evolution of similar morphologies in closely related lineages provides insight into the repeatability and predictability of evolution. In the genus Antirrhinum (snapdragons), as in other plants, a suite of morphological characters are associated with adaptation to alpine environments.

We tested for parallel trait evolution in Antirrhinum by investigating phylogenetic relationships using restriction-site associated DNA (RAD) sequencing. We then associated phenotypic information to our phylogeny to reconstruct the patterns of morphological evolution and related this to evidence for hybridisation between emergent lineages.

Phylogenetic analyses showed that the alpine character syndrome is present in multiple groups, suggesting that Antirrhinum has repeatedly …

Universal Child Health And Early Education Service Use From Birth Through Kindergarten And Developmental Vulnerability In The Preparatory Year (Age 5 Years) In Tasmania, Australia, Catherine L. Taylor, Daniel Christensen, Kim Jose, Stephen R. Zubrick

Research outputs 2014 to 2021

This study investigated patterns of universal health and education service use from birth through Kindergarten (age 4 years) and estimated associations between cumulative risk and service use patterns, and between service use patterns and children's developmental vulnerability in the Preparatory Year (age 5 years). The study used population-wide linkage of health and education administrative data records for 5168 children who had a 2018 AEDC instrument collected in Tasmania and were born in Tasmania (2011–2013). Latent class analysis (LCA) identified three service use patterns: Regular (72.2 per cent of children; reference group), Low (15.6 per cent of children) and High service …

‘Own Your Narrative’: Teenagers As Producers And Consumers Of Porn In Netflix’S Sex Education, Debra Dudek, Giselle Woodley, Lelia Green

Research outputs 2014 to 2021

Netflix’s Sex Education both represents sex education and educates viewers about sex. From the opening scene of the first episode, viewers are positioned to see this series as one that is not afraid to represent explicitly the details of a range of sexual experiences. The series’ frank depiction of sexual relationships between characters, and its exploration of characters’ hopes, fears, and choices regarding ways to express their sexual desire is, arguably, ground-breaking. This paper focuses upon the ways in which the series represents young people as producers and consumers of pornographic/erotic narratives, harnessing the communication options within their social settings …

Analysis Of Short-Term Efficacy Of Gasless Single-Port Laparoscopic Inguinal Lymphadenectomy Through Vulva Incision For Vulvar Cancer, Jin Ding, Piaopiao Teng, Xiaoming Guan, Yonghong Luo, Huafeng Ding, Suhua Shi, Xiufen Zhou, Guantai Ni

Faculty, Staff and Students Publications

OBJECTIVE: To investigate the feasibility and short-term efficacy of gasless single-port laparoscopic inguinal lymphadenectomy through vulva incision (VEIL-V).

METHODS: The data of 9 patients diagnosed as vulvar squamous cell carcinoma who underwent single-port laparoscopic inguinal lymph node dissection through vulvectomy incision were retrospectively analyzed. And 13 patients who underwent laparoscopic inguinal lymph node dissection through lower abdominal subcutaneous approach as the control group (VEIL-H). The operation time, blood loss, numbers of unilateral lymph nodes, hospitalization time, and complications between the two groups were compared.

RESULTS: The operation time of VEIL-V was 56.11 ± 5.94 min, which were shorter than that …

Systematic Profiling Of Dnmt3a Variants Reveals Protein Instability Mediated By The Dcaf8 E3 Ubiquitin Ligase Adaptor, Yung-Hsin Huang, Chun-Wei Chen, Venkatasubramaniam Sundaramurthy, Mikołaj Słabicki, Dapeng Hao, Caroline J Watson, Ayala Tovy, Jaime M Reyes, Olga Dakhova, Brielle R Crovetti, Christina Galonska, Minjung Lee, Lorenzo Brunetti, Yubin Zhou, Katrina Tatton-Brown, Yun Huang, Xiaodong Cheng, Alexander Meissner, Peter J M Valk, Lionel Van Maldergem, Mathijs A Sanders, Jamie R Blundell, Wei Li, Benjamin L Ebert, Margaret A Goodell

Faculty, Staff and Students Publications

Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A (DNMT3A) are the most common driver of this state. DNMT3A variants occur across the gene with some particularly associated with malignancy, but the functional relevance and mechanisms of pathogenesis of the majority of mutations are unknown. Here, we systematically investigated the methyltransferase activity and protein stability of 253 disease-associated DNMT3A mutations, and found that 74% were loss-of-function mutations. Half of these variants exhibited reduced protein stability and, as a class, correlated with greater clonal expansion and acute …

Neighborhood Tenure, Donated Social Support, And Participation In Low- And Moderate-Income Communities, Megan E. Gilster

The Journal of Sociology & Social Welfare

Understanding what facilitates participation in neighborhood civic life is important for improving participatory interventions, and ultimately improving neighborhoods. The longer someone lives in a neighborhood, the more likely they are to participate in their neighborhood by organizing with neighbors, volunteering, or taking on a leadership role in a neighborhood organization. At the same time, the longer someone lives in a socioeconomically disadvantaged neighborhood, the more social ties they develop, which may increase social obligations. The present study examines whether helping friends and family (i.e., donated social support) is a barrier to neighborhood participation. Data come from the Anne E. Casey …

Adult-Onset And Adolescent-Limited Suicidal Ideation: A Developmental Approach To Suicide, Brent Teasdale, Michelle N. Harris, Mindy Bradley, Suraiya H. Shammi, Jerreed D. Ivanich

The Journal of Sociology & Social Welfare

Suicidal thoughts and actions have typically been studied from an eventsbased perspective. Some emerging studies, however, have begun to examine suicide and related behaviors through a longitudinal perspective, specifically focusing on establishing trajectories of suicidal behavior. In general, this work produces three-class trajectories of suicide attempts among adolescents, including groups such as: (1) no or low suicidal behavior; (2) moderate suicidal behavior; and (3) high suicidal behavior. Less is known about potential trajectory patterns of suicidal ideation associated with later stages of the life course. Moreover, identifying a low-, moderate-, and high-risk group does not inform the developmental processes that …

Insistence: The Active Quest Of Citizens For Achieving Their Health And Justice Rights In Mexico, Julia Hernández-Gutiérrez

The Journal of Sociology & Social Welfare

In Mexico’s public healthcare and justice institutions, where insufficient infrastructure, unnecessary, confusing procedures, and mistreatment are common obstacles to fundamental rights, insistence can be interpreted as an indicator of a citizen’s active quest to ensure their rights are respected. Even if citizen dependence on the State is reinforced on a daily basis within some public institutions, service users are not inactive patients or victims waiting for their turn, but rather are active agents claiming their rights, because access to healthcare and justice cannot be achieved in Mexico without the ability to cope with bureaucratic barriers and the despotic attitude of …