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2022

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Articles 93421 - 93450 of 93601

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Identifying Effective Interventions To Promote Consumption Of Protein-Rich Foods From Lower Ecological Footprint Sources: A Systematic Literature Review, Rimante Ronto, Golsa Saberi, Gianna Maxi Leila Robbers, Stephanie Godrich, Mark Lawrence, Shawn Somerset, Jessica Fanzo, Josephine Chau Jan 2022

Identifying Effective Interventions To Promote Consumption Of Protein-Rich Foods From Lower Ecological Footprint Sources: A Systematic Literature Review, Rimante Ronto, Golsa Saberi, Gianna Maxi Leila Robbers, Stephanie Godrich, Mark Lawrence, Shawn Somerset, Jessica Fanzo, Josephine Chau

Research outputs 2022 to 2026

Addressing overconsumption of protein-rich foods from high ecological footprint sources can have positive impacts on health such as reduction of non-communicable disease risk and protecting the natural environment. With the increased attention towards development of ecologically sustainable diets, this systematic review aimed to critically review literature on effectiveness of those interventions aiming to promote protein-rich foods from lower ecological footprint sources. Five electronic databases (Medline, Web of Science, Scopus, Embase and Global Health) were searched for articles published up to January 2021. Quantitative studies were eligible for inclusion if they reported on actual or intended consumption of protein-rich animal-derived and/or …


Rapid Triage For Ischemic Stroke: A Machine Learning-Driven Approach In The Context Of Predictive, Preventive And Personalised Medicine, Yulu Zheng, Zheng Guo, Yanbo Zhang, Jianjing Shang, Leilei Yu, Ping Fu, Yizhi Liu, Xingang Li, Hao Wang, Ling Ren, Wei Zhang, Haifeng Hou, Xuerui Tan, Wei Wang, Global Health Epidemiology Reference Group (Gherg) Jan 2022

Rapid Triage For Ischemic Stroke: A Machine Learning-Driven Approach In The Context Of Predictive, Preventive And Personalised Medicine, Yulu Zheng, Zheng Guo, Yanbo Zhang, Jianjing Shang, Leilei Yu, Ping Fu, Yizhi Liu, Xingang Li, Hao Wang, Ling Ren, Wei Zhang, Haifeng Hou, Xuerui Tan, Wei Wang, Global Health Epidemiology Reference Group (Gherg)

Research outputs 2022 to 2026

Background

Recognising the early signs of ischemic stroke (IS) in emergency settings has been challenging. Machine learning (ML), a robust tool for predictive, preventive and personalised medicine (PPPM/3PM), presents a possible solution for this issue and produces accurate predictions for real-time data processing.

Methods

This investigation evaluated 4999 IS patients among a total of 10,476 adults included in the initial dataset, and 1076 IS subjects among 3935 participants in the external validation dataset. Six ML-based models for the prediction of IS were trained on the initial dataset of 10,476 participants (split participants into a training set [80%] and an internal …


5-Ht2 Receptor Antagonism Reduces Human Motoneuron Output To Antidromic Activation But Not To Stimulation Of Corticospinal Axons, Jacob R. Thorstensen, Janet L. Taylor, Justin J. Kavanagh Jan 2022

5-Ht2 Receptor Antagonism Reduces Human Motoneuron Output To Antidromic Activation But Not To Stimulation Of Corticospinal Axons, Jacob R. Thorstensen, Janet L. Taylor, Justin J. Kavanagh

Research outputs 2022 to 2026

The intrinsic electrical properties of motoneurons strongly affect motoneuron excitability to fast-acting excitatory ionotropic inputs. Serotonin (5-HT) is a neurochemical that alters the intrinsic properties of motoneurons, whereby animal models and in vitro experiments indicate that 5-HT increases motoneuron excitability by activating 5-HT2 receptors on the somato-dendritic compartment. In the current study, we examined how antagonism of the 5-HT2 receptor affects motoneuron excitability in humans. We hypothesised that motoneuron excitability would be reduced. The 5-HT2 antagonist cyproheptadine was administered to 10 healthy participants in a double-blinded, placebo-controlled, crossover trial. Electrical cervicomedullary stimulation was used to deliver a synchronised excitatory volley …


Epidemiology Of ∆8thc-Related Carcinogenesis In Usa: A Panel Regression And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse Jan 2022

Epidemiology Of ∆8thc-Related Carcinogenesis In Usa: A Panel Regression And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

The use of ∆8THC is increasing at present across the USA in association with widespread cannabis legalization and the common notion that it is “legal weed”. As genotoxic actions have been described for many cannabinoids, we studied the cancer epidemiology of ∆8THC. Data on 34 cancer types was from the Centers for Disease Control Atlanta Georgia, substance abuse data from the Substance Abuse and Mental Health Services Administration, ethnicity and income data from the U.S. Census Bureau, and cannabinoid concentration data from the Drug Enforcement Agency, were combined and processed in R. Eight cancers (corpus uteri, liver, gastric cardia, breast …


Fine-Grained Ship Image Recognition Based On Bcnn With Inception And Am-Softmax, Zhilin Zhang, Ting Zhang, Zhaoying Liu, Peijie Zhang, Shanshan Tu, Yujian Li, Muhammad Waqas Jan 2022

Fine-Grained Ship Image Recognition Based On Bcnn With Inception And Am-Softmax, Zhilin Zhang, Ting Zhang, Zhaoying Liu, Peijie Zhang, Shanshan Tu, Yujian Li, Muhammad Waqas

Research outputs 2022 to 2026

The fine-grained ship image recognition task aims to identify various classes of ships. However, small inter-class, large intra-class differences between ships, and lacking of training samples are the reasons that make the task difficult. Therefore, to enhance the accuracy of the fine-grained ship image recognition, we design a fine-grained ship image recognition network based on bilinear convolutional neural network (BCNN) with Inception and additive margin Softmax (AM-Softmax). This network improves the BCNN in two aspects. Firstly, by introducing Inception branches to the BCNN network, it is helpful to enhance the ability of extracting comprehensive features from ships. Secondly, by adding …


Mediation Roles Of Pedagogical Approaches And Personality Traits In Entrepreneurial Curriculum Design And Entrepreneurial Intention Nexus, Victor Fannam Nunfam, Ebenezer Afrifa-Yamoah, Akanganngang Joseph Asitik Jan 2022

Mediation Roles Of Pedagogical Approaches And Personality Traits In Entrepreneurial Curriculum Design And Entrepreneurial Intention Nexus, Victor Fannam Nunfam, Ebenezer Afrifa-Yamoah, Akanganngang Joseph Asitik

Research outputs 2022 to 2026

Planned behaviour theory was used in a path analysis modelling to investigate the serial mediation role of teaching methods and personality traits (locus of control, need for achievement and entrepreneurial attitude) in the relationship between entrepreneurship curriculum and entrepreneurial intention among university students in Ghana. A proposed 40-item instrument was used to measure outcomes for six constructs (3 personality trait constructs, entrepreneurship curriculum, teaching methods and entrepreneurial intention) for 324 participants. Acceptable convergent, divergent and construct validity scores were observed for the instrument. Teaching methods fully mediated the first-order relationships between entrepreneurial curriculum and each personality traits. The three constructs …


Determinants Of Switching Intention In The Electricity Markets - An Integrated Structural Model Approach, Shahid Hussain, Pi-Shen Seet, Maria Ryan, Mohammad Iranmanesh, Helen Cripps, Abdul Salam Jan 2022

Determinants Of Switching Intention In The Electricity Markets - An Integrated Structural Model Approach, Shahid Hussain, Pi-Shen Seet, Maria Ryan, Mohammad Iranmanesh, Helen Cripps, Abdul Salam

Research outputs 2022 to 2026

This study adopts an integrated approach and combines the theory of planned behavior and push-pull theory to unpack the antecedents of customer switching intention in a contextual setting (Western Australia) that has a regulated electricity market. Partial least squares structural equation modeling was used to analyze data from a survey of 405 retail electricity consumers, which reveals that perceived relative price, electronic word-of-mouth, customer-based reputation of a service provider, past switching experience, and subjective norms significantly influence attitude toward switching and switching intention. Our findings contribute to the literature on retail electricity markets by showing the importance of customer-based reputation …


“It Only Hurts When I Laugh”: Tolerating Bullying Humour In Order To Belong At Work, Barbara Plester, Tim Bentley, Emily Brewer Jan 2022

“It Only Hurts When I Laugh”: Tolerating Bullying Humour In Order To Belong At Work, Barbara Plester, Tim Bentley, Emily Brewer

Research outputs 2022 to 2026

Our study examines the impacts on workers when organisational humour is repeated, sustained, dominating, and potentially harmful, and thus can be considered to be bullying. In an ethnographic study of an idiosyncratic New Zealand IT company, we observed humour that was sexualised, dominating, and perpetrated by the most powerful organizational members. We argue that the compelling need for belonging in this extreme organizational culture influenced workers to accept bullying humour as just a joke and therefore acceptable and harmless even when it contravened societal workplace norms. Our contribution is in identifying and extending the significant theoretical relationship between workplace humour …


A Retrospective Cohort Study Of Factors Associated With Severity Of Falls In Hospital Patients, Manonita Ghosh, Beverly O’Connell, Ebenezer Afrifa-Yamoah, Sue Kitchen, Linda Coventry Jan 2022

A Retrospective Cohort Study Of Factors Associated With Severity Of Falls In Hospital Patients, Manonita Ghosh, Beverly O’Connell, Ebenezer Afrifa-Yamoah, Sue Kitchen, Linda Coventry

Research outputs 2022 to 2026

Severity of falls in hospital patients are threat to patient safety which can result in a financial burden on the patient’s family and health care services. Both patient specific and environmental and organisational factors are associated with severity of falls in hospital. It is important to continuously analyse the factors associated with severity of fall which can inform the implementation of any fall preventive strategies. This study aims to identify factors associated with the severity of falls in hospitalised adult patients in Western Australia. This study involved a retrospective cohort analysis of inpatient falls records extracted from the hospital’s Clinical …


Addressing Filicide In Ghana: Linking Cultural Understanding With The Law Against Filicide. Does The Law Work?, Alhassan Abdullah, Margarita Frederico, Felix Mensah, Hajara Bentum, Yihang Wang, Jennifer Litela Asare Jan 2022

Addressing Filicide In Ghana: Linking Cultural Understanding With The Law Against Filicide. Does The Law Work?, Alhassan Abdullah, Margarita Frederico, Felix Mensah, Hajara Bentum, Yihang Wang, Jennifer Litela Asare

Research outputs 2022 to 2026

Introduction: Consistent with international promulgation on the criminalization of filicide, Ghana’s Children’s Act 1998 (560) and the Criminal Justice Act criminalizes any form of torture against children. Yet, perpetrators of filicide in Ghana may go unpunished due to the beliefs in cultural norms that justify filicide acts. The cultural narratives of filicide can impede on the application and effectiveness of the laws of filicide. Method: The study employed a vignette approach to explore the views of 19 adults, who were parents between 69 years of age and 30 years of age, in rural and urban Ghana on the laws of …


Assessment And Monitoring Of Achilles Tendinopathy In Clinical Practice: A Qualitative Descriptive Exploration Of The Barriers Clinicians Face, Myles Calder Murphy, James Debenham, Caroline Bulsara, Paola Chivers, Ebonie Kendra Rio, Sean Docking, Mervyn Travers, William Gibson Jan 2022

Assessment And Monitoring Of Achilles Tendinopathy In Clinical Practice: A Qualitative Descriptive Exploration Of The Barriers Clinicians Face, Myles Calder Murphy, James Debenham, Caroline Bulsara, Paola Chivers, Ebonie Kendra Rio, Sean Docking, Mervyn Travers, William Gibson

Research outputs 2022 to 2026

Our primary objective was to explore the barriers preventing clinicians from implementing what they think is ideal practice as it relates to using tools to aid diagnosis and monitor progress in mid-portion Achilles tendinopathy. Our secondary objectives were to describe the assessments employed by clinicians in their own practice to aid with (a) diagnosis and (b) monitoring progress in Achilles tendinopathy and explore the outcome measure domains clinicians believe to be the most and least important when managing patients with Achilles tendinopathy. We employed a qualitative descriptive study design. Thirteen participants (eight female, five male) from across Australia, consisting of …


Association Of Immunoglobulin G N-Glycosylation With Carotid Atherosclerotic Plaque Phenotypes And Actual Clinical Cardiovascular Events: A Study Protocol For A Longitudinal Prospective Cohort Study, Cuihong Tian, Gehendra Mahara, Hongxia Zhang, Xuerui Tan Jan 2022

Association Of Immunoglobulin G N-Glycosylation With Carotid Atherosclerotic Plaque Phenotypes And Actual Clinical Cardiovascular Events: A Study Protocol For A Longitudinal Prospective Cohort Study, Cuihong Tian, Gehendra Mahara, Hongxia Zhang, Xuerui Tan

Research outputs 2022 to 2026

Introduction Immune-inflammatory response plays a key role in the pathogenesis of atherosclerosis. IgG N-glycosylation is reported to be associated with the 10-year atherosclerotic cardiovascular disease risk score and subclinical atherosclerosis. However, the relationship of IgG glycosylation with actual clinical cardiovascular disease (CVD) events and plaque phenotypes has rarely been investigated. Therefore, this study aims to understand whether IgG glycosylation traits are correlated with actual clinical CVD events and plaque phenotypes. Methods and analysis Designed to verify the efficacy of IgG glycosylation as a risk for CVD events and screen potential biomarkers of CVD to prevent atherosclerosis occurrence, this longitudinal prospective …


Bioturbation By Echidna (Tachyglossus Aculeatus) In A Forest Habitat, South-Western Australia, Shannon J. Dundas, Lara Osborne, Anna J. M. Hopkins, Katinka X. Ruthrof, Patricia A. Fleming Jan 2022

Bioturbation By Echidna (Tachyglossus Aculeatus) In A Forest Habitat, South-Western Australia, Shannon J. Dundas, Lara Osborne, Anna J. M. Hopkins, Katinka X. Ruthrof, Patricia A. Fleming

Research outputs 2022 to 2026

Bioturbation by digging animals is important for key forest ecosystem processes such as soil turnover, decomposition, nutrient cycling, water infiltration, seedling recruitment, and fungal dispersal. Despite their widespread geographic range, little is known about the role of the short-beaked echidna (Tachyglossus aculeatus) in forest ecosystems. We measured the density and size of echidna diggings in the Northern Jarrah Forest, south-western Australia, to quantify the contribution echidna make to soil turnover. We recorded an overall density of 298 echidna diggings per hectare, 21 % of which were estimated to be less than 1 month old. The average size of digs was …


Comparison Of Auditory Steady-State Responses With Conventional Audiometry In Older Adults, Hadeel Y. Tarawneh, Hamid R. Sohrabi, Wilhelmina H. A. M. Mulders, Ralph N. Martins, Dona M. P. Jayakody Jan 2022

Comparison Of Auditory Steady-State Responses With Conventional Audiometry In Older Adults, Hadeel Y. Tarawneh, Hamid R. Sohrabi, Wilhelmina H. A. M. Mulders, Ralph N. Martins, Dona M. P. Jayakody

Research outputs 2022 to 2026

Behavioral measures, such as pure-tone audiometry (PTA), are commonly used to determine hearing thresholds, however, PTA does not always provide reliable hearing information in difficult to test individuals. Therefore, objective measures of hearing sensitivity that require little-to-no active participation from an individual are needed to facilitate the detection and treatment of hearing loss in difficult to test people. Investigation of the reliability of the auditory steady-state response (ASSR) for measuring hearing thresholds in older adults is limited. This study aimed to investigate if ASSR can be a reliable, objective measure of frequency specific hearing thresholds in older adults. Hearing thresholds …


European Epidemiological Patterns Of Cannabis- And Substance-Related Body Wall Congenital Anomalies: Geospatiotemporal And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse Jan 2022

European Epidemiological Patterns Of Cannabis- And Substance-Related Body Wall Congenital Anomalies: Geospatiotemporal And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2022 to 2026

As body wall congenital anomalies (BWCAs) have a long history of being associated with prenatal or community cannabis exposure (CCE), it was of interest to investigate these epidemiological relationships in Europe given the recent increases in cannabis use prevalence, daily intensity, and Δ9-tetrahydrocannabinol (THC) potency. Methods: This study makes use of BWCA data from Eurocat, drug exposure data from the European Monitoring Centre for Drugs and Drug Addiction, and income from the World Bank. Results: The mapping analysis showed that BWCARs increased in France, Spain, and the Netherlands. The bivariate mapping analysis showed that the BWCA rates (BWCAR) and the …


Flavonoid Intakes Inversely Associate With Copd In Smokers, Nicola P. Bondonno, Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Daniel Bech Rasmussen, Cecilie Kyrø, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Kim Overvad, Anja Olsen, Jonathan M. Hodgson Jan 2022

Flavonoid Intakes Inversely Associate With Copd In Smokers, Nicola P. Bondonno, Benjamin H. Parmenter, Frederik Dalgaard, Kevin Murray, Daniel Bech Rasmussen, Cecilie Kyrø, Aedin Cassidy, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. Croft, Gunnar Gislason, Augustin Scalbert, Anne Tjønneland, Kim Overvad, Anja Olsen, Jonathan M. Hodgson

Research outputs 2022 to 2026

Introduction: Higher flavonoid intakes are beneficially associated with pulmonary function parameters; however, their association with chronic obstructive pulmonary disease (COPD) is unknown. This study aimed to examine associations between intakes of 1) total flavonoids, 2) flavonoid subclasses and 3) major flavonoid compounds with incident COPD in participants from the Danish Diet, Cancer and Health study. Methods: This prospective cohort included 55 413 men and women without COPD, aged 50-65 years at recruitment. Habitual flavonoid intakes at baseline were estimated from a food frequency questionnaire using Phenol-Explorer. Danish nationwide registers were used to identify incident cases of COPD. Associations were modelled …


Identifying Industry 5.0 Contributions To Sustainable Development: A Strategy Roadmap For Delivering Sustainability Values, Morteza Ghobakhloo, Mohammad Iranmanesh, Muhammad Faraz Mubarak, Mobashar Mubarik, Abderahman Rejeb, Mehrbakhsh Nilashi Jan 2022

Identifying Industry 5.0 Contributions To Sustainable Development: A Strategy Roadmap For Delivering Sustainability Values, Morteza Ghobakhloo, Mohammad Iranmanesh, Muhammad Faraz Mubarak, Mobashar Mubarik, Abderahman Rejeb, Mehrbakhsh Nilashi

Research outputs 2022 to 2026

Scholars believe that the newly introduced Industry 5.0 has the potential to move beyond the profit-centered productivity of Industry 4.0 and to promote sustainable development goals such as human-centricity, socio-environmental sustainability, and resilience. However, little has been done to understand how this ill-defined phenomenon may deliver its indented sustainability values despite these speculative promises. To address this knowledge gap, the present study developed a strategy roadmap that explains the mechanism by which Industry 5.0 delivers its intended sustainable development functions. The study first developed and introduced the Industry 5.0 reference model that describes the technical and functional properties of this …


It’S A Matter Of Trust: Ngāi Tahu Democratic Processes And Māori Pākehā Research Partnership, Janine Joyce, Hine Forsyth Jan 2022

It’S A Matter Of Trust: Ngāi Tahu Democratic Processes And Māori Pākehā Research Partnership, Janine Joyce, Hine Forsyth

Research outputs 2022 to 2026

The Ngāi Tahu indigenous Māori community of Aotearoa/New Zealand successfully maintained 150 years of legal grievance against the British Crown following the signing of the Treaty of Waitangi and colonization. The importance of women leaders, the guiding role of elders, the long-term commitment to intergenerational health for all tribal members, the democratic processes in the current context for Ngāi Tahu iwi within Aotearoa and engagement with the legal system was crucial in building towards a post-conflict society. Alongside this there were and are creative empowerment processes that nourished cultural vitality. This paper shares a ‘conversational exchange’ about the processes that …


Long-Term Adherence To A Mediterranean Diet 1-Year After Completion Of The Medley Study, Karen J. Murphy, Kathryn A. Dyer, Belinda Hyde, Courtney R. Davis, Ella L. Bracci, Richard J. Woodman, Jonathan M. Hodgson Jan 2022

Long-Term Adherence To A Mediterranean Diet 1-Year After Completion Of The Medley Study, Karen J. Murphy, Kathryn A. Dyer, Belinda Hyde, Courtney R. Davis, Ella L. Bracci, Richard J. Woodman, Jonathan M. Hodgson

Research outputs 2022 to 2026

Mediterranean populations enjoy the health benefits of a Mediterranean diet (MedDiet), but is it feasible to implement such a pattern beyond the Mediterranean region? The MedLey trial, a 6-month MedDiet intervention vs habitual diet in older Australians, demonstrated that the participants could maintain high adherence to a MedDiet for 6 months. The MedDiet resulted in improved systolic blood pressure (BP), endothelial dilatation, oxidative stress, and plasma triglycerides in comparison with the habitual diet. We sought to determine if 12 months after finishing the MedLey study, the participants maintained their adherence to the MedDiet principles and whether the reduction in the …


Mother's Own Milk Compared With Formula Milk For Feeding Preterm Or Low Birth Weight Infants: Systematic Review And Meta-Analysis, Natalie A. Strobel, Claire Adams, Daniel R. Mcaullay, Karen M. Edmond Jan 2022

Mother's Own Milk Compared With Formula Milk For Feeding Preterm Or Low Birth Weight Infants: Systematic Review And Meta-Analysis, Natalie A. Strobel, Claire Adams, Daniel R. Mcaullay, Karen M. Edmond

Research outputs 2022 to 2026

Objectives: We assessed the effect of feeding preterm or low birth weight infants with infant formula compared with mother's own milk on mortality, morbidity, growth, neurodevelopment, and disability. Methods: We searched Medline (Ovid), Embase (Ovid), and Cochrane Central Register of Controlled Studies to October 1, 2021. Results: Forty-two studies enrolling 89 638 infants fulfilled the inclusion criteria. We did not find evidence of an effect on mortality (odds ratio [OR] 1.26, 95% confidence interval [CI] 0.91-1.76), infection (OR 1.52, 95% CI 0.98-2.37), cognitive neurodevelopment (standardized mean difference -1.30, 95% CI -3.53 to 0.93), or on growth parameters. Formula milk feeding …


Stem Cell Therapy For Insulin-Dependent Diabetes: Are We Still On The Road?, Lu Yang, Zhu-Meng Hu, Fang-Xu Jiang, Wei Wang Jan 2022

Stem Cell Therapy For Insulin-Dependent Diabetes: Are We Still On The Road?, Lu Yang, Zhu-Meng Hu, Fang-Xu Jiang, Wei Wang

Research outputs 2022 to 2026

In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore, the replacement of destroyed functional β cells with insulin-secreting cells derived from functional stem cells is a good idea as a new therapeutic idea. This review introduces the development schedule of mouse and human embryonic islets. The differences between mouse and human pancreas embryo development were also listed. Accordingly to the different sources of stem cells, the important research achievements on the differentiation of insulin-secreting β …


Understanding And Treating Suboptimal Health Status Through Tourism Engagement: An Exploratory Study Of Chinese Domestic Tourists, Jun Wen, Danni Zheng, Ian Phau Jan 2022

Understanding And Treating Suboptimal Health Status Through Tourism Engagement: An Exploratory Study Of Chinese Domestic Tourists, Jun Wen, Danni Zheng, Ian Phau

Research outputs 2022 to 2026

Objectives: Suboptimal health status (SHS) is a global public health concern of worldwide academic interest. The topic is popular in the medical sciences, including public health; however, other disciplines have paid little attention to this condition despite aging societies. This study introduced SHS into the tourism literature, a logical connection given the established positive correlation between well-being and tourism engagement. Lifestyle factors are crucial to SHS. Accordingly, this study examines tourists’ sociodemographic characteristics, tourism-related attributes, and lifestyle behaviors to compare individuals with SHS to those with optimal health status. Methods: Chinese tourists in Shandong Province, China who had visited Mount …


Voluntary Activation Of Muscle In Humans: Does Serotonergic Neuromodulation Matter?, Justin J. Kavanagh, Janet L. Taylor Jan 2022

Voluntary Activation Of Muscle In Humans: Does Serotonergic Neuromodulation Matter?, Justin J. Kavanagh, Janet L. Taylor

Research outputs 2022 to 2026

Ionotropic inputs to motoneurones have the capacity to depolarise and hyperpolarise the motoneurone, whereas neuromodulatory inputs control the state of excitability of the motoneurone. Intracellular recordings of motoneurones from in vitro and in situ animal preparations have provided extraordinary insight into the mechanisms that underpin how neuromodulators regulate neuronal excitability. However, far fewer studies have attempted to translate the findings from cellular and molecular studies into a human model. In this review, we focus on the role that serotonin (5-HT) plays in muscle activation in humans. 5-HT is a potent regulator of neuronal firing rates, which can influence the force …


Development Of A Food Composition Database For Assessing Nitrate And Nitrite Intake From Animal-Based Foods, Liezhou Zhong, Alex H. Liu, Lauren C. Blekkenhorst, Nicola P. Bondonno, Marc Sim, Richard J. Woodman, Kevin D. Croft, Joshua R. Lewis, Jonathan M. Hodgson, Catherine P. Bondonno Jan 2022

Development Of A Food Composition Database For Assessing Nitrate And Nitrite Intake From Animal-Based Foods, Liezhou Zhong, Alex H. Liu, Lauren C. Blekkenhorst, Nicola P. Bondonno, Marc Sim, Richard J. Woodman, Kevin D. Croft, Joshua R. Lewis, Jonathan M. Hodgson, Catherine P. Bondonno

Research outputs 2022 to 2026

Scope:

Nitrate and nitrite are approved food additives in some animal-based food products. However, nitrate and nitrite in foods are strictly regulated due to health concerns over methaemoglobinaemia and the potential formation of carcinogenic nitrosamines. In contrast, plants (like leafy vegetables) naturally accumulate nitrate ions; a growing body of research reveals beneficial metabolic effects of nitrate via its endogenous conversion to nitric oxide. To refine the association of dietary nitrate and nitrite intake with health outcomes, reliable measures of nitrate and nitrite intake from dietary food records are required. While a vegetable nitrate content database has been developed, there is …


Evaluation Of Virtual Screening Strategies For The Identification Of Γ-Secretase Inhibitors And Modulators, Alicia Ioppolo, Melissa Eccles, David Groth, Giuseppe Verdile, Mark Agostino Jan 2022

Evaluation Of Virtual Screening Strategies For The Identification Of Γ-Secretase Inhibitors And Modulators, Alicia Ioppolo, Melissa Eccles, David Groth, Giuseppe Verdile, Mark Agostino

Research outputs 2022 to 2026

γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor Protein (APP) and Notch family receptors. However, aberrant proteolysis of substrates has implications in the progression of disease pathologies, including Alzheimer’s disease (AD), cancers, and skin disorders. While several γ-secretase inhibitors have been identified, there has been toxicity observed in clinical trials associated with non-selective enzyme inhibition. To address this, γ-secretase modulators have been identified and pursued as more selective agents. Recent structural evidence has provided an insight into how γ-secretase inhibitors and modulators are recognized …


The Nursing Care Of People With Class Iii Obesity In An Acute Care Setting: A Scoping Review, Bev Ewens, Vivien Kemp, Mandy (Amanda) Towell-Barnard, Lisa Whitehead Jan 2022

The Nursing Care Of People With Class Iii Obesity In An Acute Care Setting: A Scoping Review, Bev Ewens, Vivien Kemp, Mandy (Amanda) Towell-Barnard, Lisa Whitehead

Research outputs 2022 to 2026

Background

Patients with Class III obesity pose unique challenges to health care staff and organisations. Care requirements of this population are unique and require specialised equipment and knowledge to meet these needs, maintain the quality of care, as well as the safety of patients and staff.

Aim

To synthesise the evidence on the nursing care of Class III obese patients in acute care settings.

Methods

A scoping review informed by JBI. CINAHL Plus, Medline, Scopus, Proquest Central, Web of Science and Embase were searched for primary research articles about the nursing management of people classified as Class III obese in …


Exploring Orthopaedic Patients’ Experiences Of Hospital Discharge: Implications For Nursing Care, Rosemary Saunders, David Dineen, Karen Gullick, Karla Seaman, Renee Graham, Sandra Finlay Jan 2022

Exploring Orthopaedic Patients’ Experiences Of Hospital Discharge: Implications For Nursing Care, Rosemary Saunders, David Dineen, Karen Gullick, Karla Seaman, Renee Graham, Sandra Finlay

Research outputs 2022 to 2026

Background

Nurses play a key role in providing discharge education. With the increased demand for orthopaedic surgery and subsequent fast‐track surgical programmes resulting in reduction in hospital length of stay, obtaining patient feedback about discharge is important to inform nursing practice of discharge.

Aim

To explore patients’ experiences of discharge from hospital following orthopaedic surgery.

Methods

A descriptive qualitative study was undertaken with a sample of 34 patients discharged following orthopaedic surgery at a private acute Australian hospital. Individual semistructured telephone interviews were conducted and analysed using inductive thematic analysis.

Findings

From the analysis, patient experiences have been described in …


Comparison Of Weightlifting, Traditional Resistance Training And Plyometrics On Strength, Power And Speed: A Systematic Review With Meta-Analysis, Stephanie J. Morris, Jon L. Oliver, Jason S. Pedley, G. Gregory Haff, Rhodri S. Lloyd Jan 2022

Comparison Of Weightlifting, Traditional Resistance Training And Plyometrics On Strength, Power And Speed: A Systematic Review With Meta-Analysis, Stephanie J. Morris, Jon L. Oliver, Jason S. Pedley, G. Gregory Haff, Rhodri S. Lloyd

Research outputs 2022 to 2026

Background:

Weightlifting training (WLT) is commonly used to improve strength, power and speed in athletes. However, to date, WLT studies have either not compared training effects against those of other training methods, or been limited by small sample sizes, which are issues that can be resolved by pooling studies in a meta-analysis. Therefore, the objective of this systematic review with meta-analysis was to evaluate the effects of WLT compared with traditional resistance training (TRT), plyometric training (PLYO) and/or control (CON) on strength, power and speed.

Methods:

The systematic review included peer-reviewed articles that employed a WLT intervention, a comparison group …


Feasibility And Therapeutic Efficacy Of A Two-Week Low-Level Laser Acupuncture Therapy For Shoulder And Neck Pain In Office Workers: Protocol For A Pilot, Single-Blind, Doublearmed, Randomised Controlled Trial, Carol Chunfeng Wang, Lisa Whitehead, Travis Cruickshank, Johnny Lo, Jianhong Xia, Jun Wen Jan 2022

Feasibility And Therapeutic Efficacy Of A Two-Week Low-Level Laser Acupuncture Therapy For Shoulder And Neck Pain In Office Workers: Protocol For A Pilot, Single-Blind, Doublearmed, Randomised Controlled Trial, Carol Chunfeng Wang, Lisa Whitehead, Travis Cruickshank, Johnny Lo, Jianhong Xia, Jun Wen

Research outputs 2022 to 2026

Background:

Shoulder and neck pain (SNP) is common in office workers and represents a serious public health problem given its detrimental impact on quality of life, physical functioning, personal finances, employers, and the health care system. Management with painkillers has adverse implications such as tolerance, addiction, and opioid abuse. Safe, sustainable, cost-effective, and evidence-based solutions are urgently needed. The non-invasive, painless, noninfectious, and safe modality of low-level laser acupuncture (LLLA) has shown promise for SNP management.

Objective:

The overarching aim of this study is to provide evidence of the feasibility and therapeutic efficacy of LLLA for office workers with SNP. …


Determinants Of Sme’S Social Media Marketing Adoption: Competitive Industry As A Moderator, Ghazanfar Ali Abbasi, Noor Fareen Abdul Rahim, Hongyan Wu, Mohammad Iranmanesh, Benjamin Ng Chee Keong Jan 2022

Determinants Of Sme’S Social Media Marketing Adoption: Competitive Industry As A Moderator, Ghazanfar Ali Abbasi, Noor Fareen Abdul Rahim, Hongyan Wu, Mohammad Iranmanesh, Benjamin Ng Chee Keong

Research outputs 2022 to 2026

In light of the growing role of social media marketing in the success of businesses and its low adoption rate among small and medium enterprises (SMEs), this study aims to identify determinants of SMEs’ social media marketing adoption by considering the competitive industry as a moderator. Data were collected from 214 SMEs in Malaysia. Unlike extant literature, this study proposed a dual-stage analysis involving partial least squares (PLS) technique and artificial intelligence named deep artificial neural network (ANN). The application of deep ANN architecture is used to predict 91% of accuracy for the proposed model. The results showed that perceived …