Digital Commons Network^™

Formal Ethics Education In Speech-Language Pathology Graduate Students, Jennifer N. Gaylord

Murray State Theses and Dissertations

Ethical service provision is an essential foundational skill for speech-language pathologists (SLPs) and is fundamental for maintaining the integrity of the profession of speech-language pathology. While practicing speech-language pathologists are required to complete formal ethics training during each certification maintenance interval, there are no guidelines set forth as to the amount and type of training for graduate students in speech-language pathology. This quasi-experimental investigation compared the effect of ethics training embedded within a curriculum to formal ethics training on the ethics knowledge and self-reported comfort levels of first-year graduate students in speech-language pathology. Two equal, non-randomized groups of participants completed …

Using Design Thinking As An Instrument For School Improvement And Innovation In Public Schools, Beth Emery Peterson

Murray State Theses and Dissertations

Design thinking, a creative problem-solving method in which the end user is an active member of the design team, has historically been used in business and industry, but school leaders are beginning to use the process in education settings. This multiple-case study examined the experiences of two public school leaders who used design thinking for continuous improvement initiatives or to spur innovation in their school or district. Through interviews, the school leaders shared their purposes, outcomes, challenges, and insights of using design thinking to address complex educational problems. Results indicate that design thinking is appropriate to use for continuous improvement …

Habitat Use And Diel Movements Of Silver Carp Hypophthalmichthys Molitrix In Two Southeastern Reservoirs, Levi Umland

Murray State Theses and Dissertations

Bigheaded carp have spread rampantly throughout the Mississippi watershed and continue to spread by navigating through rivers, locks, and dams. The long-term effects these species will have on our ecosystems and natural resources is unknown. Their movements, behavior, and general seasonal patterns are well studied within rivers. However, their movements and behavior within reservoirs is poorly understood due to their initial numbers within reservoirs being lower than in rivers. To address this gap, I investigated the distribution and movement rates of Silver Carp within two reservoirs, Kentucky Reservoir and Barkley Reservoir, and possible correlative variables, including wind, temperature, residency, sex, …

A Phenomenological Study On Increasing The Number Of Student Veterans In Graduate And Postgraduate Degree Programs At A Comprehensive Mid-Sized Regional University, Scott R. Allen

Murray State Theses and Dissertations

This phenomenological study examined how a comprehensive mid-sized regional university can attract, retain and graduate more graduate and postgraduate student veterans. This study was framed by a grand tour question, three research questions, and several sub-tiered questions. Data collected from interviews with student veterans pursuing graduate and postgraduate degrees after receiving a baccalaureate are examined. The experiences noted and documented in this study show that the motivation for student veterans to pursue graduate and doctoral degrees is based primarily on data gleaned from personal interviews and data collected from those interviews. The participants stated that the availability of veteran educational …

Overlooked And Under-Referred, Gretchen Spencer

Murray State Theses and Dissertations

Abstract

According to the National Association for Gifted Children (2019) up to 10% of the population can benefit from receiving gifted services. Due to wide variability in definition, identification and services offered, the NAGC recognized that gifted students have been and continue to be overlooked (NAGC, 2019). Not only are gifted students under identified overall, the ratio of identified students who are Black, Latine, special education, and female was lower than the ratio in the population and occurred at a significantly lower rate than their white counterparts (Ecker-Lyster & Niileksela, 2017). The issue of underrepresentation within the gifted population has …

Cte Instructors: Preparation To Involvment For Success For Students With Disabilities, Nancy Cavness

Murray State Theses and Dissertations

Abstract

This researcher conducted a quantitative study with help from career and technical (CTE) instructors across Tennessee. The research was to determine how prepared CTE instructors were work with students with disabilities (SWD). CTE teachers who responded gave data pertaining to receiving and involvement in Individualized Education Plan (IEP) process, professional development, and collaboration with stakeholders so SWD would meet success. The data suggests CTE instructors were somewhat involved in the IEP process, but more focus needed to be in areas of training and collaboration.

Return Of Floodplain Connectivity And Concurrent Macroinvertebrate Community Response Following Wetland Restoration In Western Kentucky, Christiane M. Soldo Ms.

Murray State Theses and Dissertations

Wetlands improve the quality of our nation’s streams, rivers, and lakes, and they support a diverse assemblage of plant and animal species. The U.S. Department of Agriculture Natural Resources Conservation Service (USDA-NRCS) is responsible for administering the Wetland Reserve Program (WRP), a multi-billion-dollar effort to restore wetlands throughout the nation. Each year, WRP enrolls thousands of acres of private farmland into conservation easements with the goal of improving water quality and creating wildlife habitat. Hydrological modification structures, such as levee breaks, ditch plugs, or shallow water areas are constructed on easements to create wetlands by improving water retention and returning …

A Phase 1b Study Of Telisotuzumab Vedotin In Combination With Nivolumab In Patients With Nsclc, D Ross Camidge, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Telisotuzumab vedotin (Teliso-V) is an anti-c-Met-directed antibody-drug conjugate that has exhibited antitumor activity as monotherapy in NSCLC. Its potential activity combined with programmed cell death protein-1 inhibitors has not been previously evaluated.

METHODS: In a phase 1b study (NCT02099058), adult patients (≥18 y) with advanced NSCLC received combination therapy with Teliso-V (1.6, 1.9, or 2.2 mg/kg, every 2 wk) plus nivolumab (3 mg/kg, 240 mg, or per locally approved label). The primary objective was to assess safety and tolerability; secondary objectives included the evaluation of antitumor activity.

RESULTS: As of January 2020, a total of 37 patients received treatment …

Psychiatric Comorbidity And Psychosocial Stressors Among People Initiating Hiv Care In Cameroon, Angela M. Parcesepe, Lindsey M. Filiatreau, Peter Vanes Ebasone, Anastase Dzudie, Brian W. Pence, Milton Wainberg, Marcel Yotebieng, Kathryn Anastos, Eric Pefura-Yone, Denis Nsame, Rogers Ajeh, Denis Nash

2020-Current year OA Pubs

BACKGROUND: Psychiatric comorbidity, the presence of two or more mental health disorders, has been associated with suboptimal HIV treatment outcomes. Little is known about the prevalence of psychiatric comorbidity among people with HIV (PWH) in sub-Saharan Africa.

METHODS: We conducted interviews with PWH initiating HIV care in Cameroon between June 2019 and March 2020. Depression, anxiety, post-traumatic stress disorder (PTSD), and harmful drinking were dichotomized to represent those with and without symptoms of each. Psychiatric comorbidity was defined as having symptoms of two or more disorders assessed. Moderate or severe household hunger, high anticipatory HIV-related stigma, low social support, and …

Characteristics Of Antifungal Utilization For Hospitalized Children In The United States, Lourdes Eguiguren, Brian R Lee, Jason G Newland, Matthew P Kronman, Adam L Hersh, Jeffrey S Gerber, Grace M Lee, Hayden T Schwenk

2020-Current year OA Pubs

OBJECTIVE: To characterize antifungal prescribing patterns, including the indication for antifungal use, in hospitalized children across the United States.

DESIGN: We analyzed antifungal prescribing data from 32 hospitals that participated in the SHARPS Antibiotic Resistance, Prescribing, and Efficacy among Children (SHARPEC) study, a cross-sectional point-prevalence survey conducted between June 2016 and December 2017.

METHODS: Inpatients aged <18 years with an active systemic antifungal order were included in the analysis. We classified antifungal prescribing by indication (ie, prophylaxis, empiric, targeted), and we compared the proportion of patients in each category based on patient and antifungal characteristics.

RESULTS: Among 34,927 surveyed patients, 2,095 (6%) received at least 1 systemic antifungal and there were 2,207 antifungal prescriptions. Most patients had an underlying oncology or bone marrow transplant diagnosis (57%) or were premature (13%). The most prescribed antifungal was fluconazole (48%) and the …

The Longitudinal Impact Of Maternal Depression And Neighborhood Social Context On Adolescent Mental Health, Daphne Lew, Hong Xian, Travis Loux, Enbal Shacham, Darcell Scharff

2020-Current year OA Pubs

PURPOSE: Maternal depression and neighborhood characteristics are known to be associated both with each other and with adolescent mental health outcomes. These exposures are also subject to change throughout the life of a child. This study sought to identify multi-trajectories of maternal depression (MD) and self-reported neighborhood collective efficacy (NCE) over a 12-year period and determine whether these trajectories are differentially associated with adolescent mental health.

METHODS: Data from the Fragile Families and Child Wellbeing study, a longitudinal cohort study of new parents and their children, were used. Maternal depression (MD) and self-reported NCE when the child was 3, 5, …

Avoid Or Embrace? Practice Effects In Alzheimer's Disease Prevention Trials, Andrew J Aschenbrenner, Jason Hassenstab, Guoqiao Wang, Yan Li, Chengjie Xiong, Eric Mcdade, David B Clifford, Randall J Bateman, Et Al.

2020-Current year OA Pubs

Demonstrating a slowing in the rate of cognitive decline is a common outcome measure in clinical trials in Alzheimer's disease (AD). Selection of cognitive endpoints typically includes modeling candidate outcome measures in the many, richly phenotyped observational cohort studies available. An important part of choosing cognitive endpoints is a consideration of improvements in performance due to repeated cognitive testing (termed "practice effects"). As primary and secondary AD prevention trials are comprised predominantly of cognitively unimpaired participants, practice effects may be substantial and may have considerable impact on detecting cognitive change. The extent to which practice effects in AD prevention trials …

Prescribing Unproven Cancer Drugs: Physician Perspectives On Expanded Access And Right To Try, Haley Manley, Bryan A Sisk, Zubin Master, Christopher Thomas Scott

2020-Current year OA Pubs

BACKGROUND: For gravely ill patients who have no treatment options and who are ineligible for clinical trials, the US Food and Drug Administration (FDA) established the Expanded Access Program (EAP). Motivated by efforts to weaken FDA regulation and sold as providing greater access to experimental drugs, the federal Right to Try Act (RTT) was passed in 2017. It reduces FDA oversight by not requiring physicians to report safety data and foregoes approval of protocols by local institutional review boards.

METHODS: This study explored the views of 17 neuro-oncologists from 15 different academic medical centers with varying experience with EAP and …

Exploring The Role Of Low-Density Neutrophils During Mycobacterium Tuberculosis Infection, Ananda N Rankin, Skyler V Hendrix, Sumanta K Naik, Christina L Stallings

2020-Current year OA Pubs

Tuberculosis (TB) is caused by infection with the bacterium

Multicenter, Prospective Validation Of A Phenotypic Algorithm To Guide Carbapenemase Testing In Carbapenem-Resistant Pseudomonas Aeruginosa Using The Erace-Pa Global Surveillance Program, Christian M. Gill, Carey-Ann D. Burnham, Et Al

Open Access Publications

Background: Carbapenemase-producing, carbapenem-resistant

Methods: CRPA isolates were collected during the Enhancing Rational Antimicrobials for

Results: A total of 807 CRPA were assessed, and 464 isolates met the algorithm criteria described above. Overall, testing was reduced by 43% compared with testing all CRPA. Carbapenemase-positive isolates missed by the algorithm were largely driven by Guiana extended spectrum (GES). Addition of the criterion of imipenem- or meropenem-resistant plus ceftolozane/tazobactam-nonsusceptible decreased the number of CP-CRPA missed by the algorithm (21 vs 40 isolates, respectively), reducing number of isolates tested by 39%.

Conclusions: Application of the initial algorithm (imipenem- or meropenem-resistant plus ceftazidime-nonsusceptible plus cefepime-nonsusceptible) …

An Overview Of Treatment Options For Patients With Relapsed/Refractory Multiple Myeloma And Renal Impairment, Meletios A Dimopoulos, Joseph Mikhael, Evangelos Terpos, Xavier Leleu, Philippe Moreau, Joan Bladé, Jin Seok Kim, Keith Stockerl-Goldstein, Paul G Richardson

Open Access Publications

Renal impairment (RI) is a relatively common complication of multiple myeloma, which increases in frequency as disease becomes more advanced and recovery of renal function becomes less likely as patients progress through lines of therapy. Clinical trials in the relapsed/refractory multiple myeloma (RRMM) setting have not uniformly included patients with RI or robustly reported their outcomes. Here, we review existing data among patients with RI and RRMM across drug classes (including immunomodulatory agents, proteasome inhibitors, monoclonal antibodies, antibody-drug conjugates, chimeric antigen receptor T-cell therapies, and exportin-1 inhibitor) to provide an improved understanding of available treatment options for this important population. …

Quantifying Rural Disparity In Healthcare Utilization In The United States: Analysis Of A Large Midwestern Healthcare System, Akua Nuako, Jingxia Liu, Giang Pham, Nina Smock, Aimee James, Timothy Baker, Laura Bierut, Graham Colditz, Li-Shiun Chen

Open Access Publications

PURPOSE: The objective of this study is to identify how predisposing characteristics, enabling factors, and health needs are jointly and individually associated with epidemiological patterns of outpatient healthcare utilization for patients who already interact and engage with a large healthcare system.

METHODS: We retrospectively analyzed electronic medical record data from 1,423,166 outpatient clinic visits from 474,674 patients in a large healthcare system from June 2018-March 2019. We evaluated patients who exclusively visited rural clinics versus patients who exclusively visited urban clinics using Chi-square tests and the generalized estimating equation Poisson regression methodology. The outcome was healthcare use defined by the …

Unique Challenges To Diagnosing Human Herpesvirus-6 (Hhv-6) Encephalitis Following Post-Hematopoietic Stem Cell Transplant: A Case And Brief Review, Harrison Zhu, Amir Ali, Karrune V Woan, Eric Tam, George Yaghmour, Alan Flores, Preet Chaudhary

Faculty, Staff and Students Publications

A patient with an ultimate diagnosis of human herpesvirus-6 (HHV-6) encephalitis developed central nervous system (CNS) symptoms 13 days after undergoing myeloablative haploidentical allogeneic hematopoietic stem cell transplant (HSCT). Due to the patient's body habitus, magnetic resonance (MR) imaging was not obtained until the onset of retrograde amnesia on day +24. MR imaging and other clinical findings eliminated all skepticism of HHV-6 encephalitis and HHV-6 antivirals were initiated on day +28, leading to gradual recovery. This case demonstrates some of the factors that may complicate the diagnosis of post-alloHSCT HHV-6 encephalitis. Because HHV-6 encephalitis and viremia can occur without warning, …

Generals Of The Resistance: Multistate Actions And Nationwide Injunctions, Elysa M. Dishman

Faculty Scholarship

State attorneys general (AGs) have become leaders of the political resistance against recent presidential administrations. They are suing the federal government with increasing frequency, seeking nationwide injunctions that thwart presidential priorities and shape national policies.

Nationwide injunctions have sparked considerable debate among jurists, scholars, and policymakers. However, the largely court-centric debate has overwhelmingly overlooked the role that state litigants and litigators play in shaping criticisms of the nationwide injunction. States and AGs have unique
attributes, advantages, and incentives that allow them to frequently seek and successfully secure nationwide injunctions. And these advantages are enhanced when states litigate together. Because states …

Delaware's Frontier, Matthew C. Jennejohn, D. Gordon Smith

Faculty Scholarship

This essay, prepared for a symposium honoring Chief Justice Leo Strine, explores how institutional capacity limits the Delaware courts’ role in the U.S. economy. A decision theoretic approach is employed to delineate the boundaries of that role, with particular attention paid to recent arguments that Delaware's Caremark doctrine should be extended to ESG concerns. The essay views muscular expansion of Caremark to encompass stakeholder interests as misguided without significant investments in institutional capacity.

Contractual Evolution, Matthew C. Jennejohn, Eric Talley

Faculty Scholarship

Conventional wisdom portrays contracts as static distillations of parties’ shared intent at some discrete point in time. In reality, however, contract terms evolve in response to their environments, including new laws, legal interpretations, and economic shocks. While several legal scholars have offered stylized accounts of this evolutionary process, we still lack a coherent, general theory that broadly captures the dynamics of real-world contracting practice. This paper advances such a theory, in which the evolution of contract terms is a byproduct of several key features, including efficiency concerns, information, and sequential learning by attorneys who negotiate several deals over time. Each …

The Transactional Dynamics Of Market Fragility, Matthew C. Jennejohn

Faculty Scholarship

This Article takes a step toward more clearly diagnosing market fragility for the purpose of developing better policy choices that anticipate and address future crises. It does so by connecting two erstwhile and distinct literatures: the legal scholarship on relational contracting and the social science on the diffusion of shocks in economic networks. This Article attempts to connect the strategies parties pursue in designing their agreements—a familiar topic to contract scholars—to the diffusion patterns observed in disrupted markets—an increasingly important area of study in macroeconomics. By investigating that intersection, this Article introduces a new potential policy domain for remediating market …

International Law: Corpus Linguistics And Ordinary Meaning, Eric Talbot Jensen, James Lee Rex

Faculty Scholarship

The application of corpus linguistics to clarify ambiguity or provide insight in legal interpretation is quickly gaining recognition within the United States, especially among the judiciary. However, very little has been done to assess its application to international law, particularly as a means of assisting international courts and tribunals. In the international legal system—where ambiguity inevitably arises from the great diversity of linguistic and cultural systems throughout the world—the norm for understanding contested terms within a treaty or agreement is to look for the “ordinary meaning to be given to the terms of the treaty in their context and in …

Revitalizing Tribal Sovereignty In Treatymaking, David H. Moore, Michalyn Steele

Faculty Scholarship

In the current model of federal-Indian relations, the United States claims a plenary legislative power, as putative guardian, to regulate Indian tribes. Under this model, tribes are essentially wards in a state of pupilage. But the federal-tribal relationship was not always so. Originally, the federal government embraced, even promoted, a more robust model of tribal sovereignty in which federal-Indian treatymaking and diplomacy figured prominently. Through treaties, the United States and tribes negotiated territorial boundaries, forged alliances, facilitated trade, and otherwise managed their relations. In 1871, Congress attempted to put an end to federal-Indian treatymaking by purporting to strip tribes of …

The Work Is Not Done: Frederick Douglass And Black Suffrage, Bradley Rebeiro

Faculty Scholarship

Since antiquity, political theorists have tried to identify the proper balance between ideals and pragmatism in political and public life. Machiavelli and Aristotle both offered prudence as an approach, but with different ends in mind: stability and the good, respectively. Among the many contributions Kurt Lash’s two-volume set on the Reconstruction Amendments provides to present-day discourse, it supplies the careful reader an answer to this timeless question by highlighting the role of Frederick Douglass in public deliberation over the Fifteenth Amendment. In this essay I argue that American abolitionist, social reformer and statesman Frederick Douglass illustrates and enacts the Aristotelian …

Coase And Accommodation: A Reply, Frederick Mark Gedicks

Faculty Scholarship

Written for a Festschrift in honor of Michael Perry, this essay responds to the argument that the Coase theorem refutes the third-party harm doctrine, which holds that the Establishment Clause prohibits any religious accommodation imposing material burdens (“harms”) on those who derive no benefit from the accommodation because they do not engage in the exempted practice (“third parties”). In economic terms, the third-party harm doctrine prohibits negative externalities created by religious accommodations which shift material costs of practicing the accommodated religion to a relatively small number of third parties who practice a different religion or none at all.

Enter Coase, …

Reforming State Bail Reform, Shima Baradaran Baughman

Faculty Scholarship

We are waist-deep in the third wave of bail reform. Scholars, policy makers, and the public have realized that the short period of detention before trial creates ripple effects on a defendant’s judicial fate and has lasting impacts on our system of mass incarceration. Over 200 proposed bail bills are pending throughout the states. This is not the first period of bail reform in America—two previous waves of bail reform in the 1960s and 1980s have both ended in increased pretrial detention for defendants. Some of the recent efforts in the third wave of bail reform have also increased detention …

Innovation In A Time Of Crisis: The Utah Supreme Court's Order On Emergency Diploma Privilege, Catherine Bramble

Faculty Scholarship

This article discusses the Utah Supreme Court's order on emergency diploma privilege during the COVID-19 pandemic.

Actively Achieving Greater Racial Equity In The Law School Classroom, Catherine Bramble

Faculty Scholarship

2020 and 2021 continue to illustrate the pervasiveness of implicit and explicit racism in our society. Less well-acknowledged and recognized is the extent to which Socratic pedagogy also reflects those pervasive racist realities while simultaneously resulting in inferior learning based on a teaching method invented 150+ years ago. Despite this racist and outdated reality, the legal academy has been reluctant to alter the traditional method of teaching. Tangible, empirical evidence obtained from data-driven cognitive learning science research demonstrates that active learning not only improves learning outcomes for all students, but also mitigates the structural effects of racism in the classroom …

A Deep Learning Model Compression And Ensemble Approach For Weed Detection, Martinson Ofori, Omar El-Gayar, Austin O'Brien

Research & Publications

Site-specific weed management is an important practice in precision agriculture. Current advances in artificial intelligence have resulted in the use of large deep convolutional neural networks for weed detection. In this paper, a transfer learning, model compression, and ensemble learning approach is introduced that is suitable for resource-limited hardware such as mobile and embedded devices. The resulting ensemble model achieves 91.2% classification accuracy which is comparable to the performance of state-of-the-art deep learning models (such as the vanilla VGG16, DenseNet, and ResNet) while being about 62.22% smaller in size than DenseNet (the smallest-sized full-sized model). The approach used in this …