Digital Commons Network^™

Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection: A Case Series From A 12-Month Longitudinal Occupational Cohort, Christina D. Mack, Caroline Tai, Robby Sikka, Yonatan H. Grad, Lisa L. Maragakis, Nathan D. Grubaugh, Deverick J. Anderson, David Ho, Michael Merson, Radhika M. Samant, Joseph R. Fauver, James Barrett, Leroy Sims, John Difiori

Journal Articles: Epidemiology

Findings are described in 7 patients with severe acute respiratory syndrome coronavirus 2 reinfection from the National Basketball Association 2020-2021 occupational testing cohort, including clinical details, antibody test results, genomic sequencing, and longitudinal reverse-transcription polymerase chain reaction results. Reinfections were infrequent and varied in clinical presentation, viral dynamics, and immune response.

Sequencing Sars-Cov-2 Genomes From Saliva, Tara Alpert, Chantal B. F. Vogels, Mallery I. Breban, Mary E. Petrone, Anne L. Wyllie, Nathan D. Grubaugh, Joseph R. Fauver

Journal Articles: Epidemiology

Genomic sequencing is crucial to understanding the epidemiology and evolution of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Often, genomic studies rely on remnant diagnostic material, typically nasopharyngeal (NP) swabs, as input into whole-genome SARS-CoV-2 next-generation sequencing pipelines. Saliva has proven to be a safe and stable specimen for the detection of SARS-CoV-2 RNA via traditional diagnostic assays; however, saliva is not commonly used for SARS-CoV-2 sequencing. Using the ARTIC Network amplicon-generation approach with sequencing on the Oxford Nanopore MinION, we demonstrate that sequencing SARS-CoV-2 from saliva produces genomes comparable to those from NP swabs, and that RNA extraction is …

Uncertainty, Scarcity And Transparency: Public Health Ethics And Risk Communication In A Pandemic, Abigail Lowe, Teck Chuan Voo, Lisa M. Lee, Kelly K. Dineen Gillespie, Christy Feig, Alva O. Ferdinand, Seema Mohapatra, David Brett-Major, Matthew K. Wynia

Journal Articles: Epidemiology

Communicating public health guidance is key to mitigating risk during disasters and outbreaks, and ethical guidance on communication emphasizes being fully transparent. Yet, communication during the pandemic has sometimes been fraught, due in part to practical and conceptual challenges around being transparent. A particular challenge has arisen when there was both evolving scientific knowledge on COVID-19 and reticence to acknowledge that resource scarcity concerns were influencing public health recommendations. This essay uses the example of communicating public health guidance on masking in the United States to illustrate ethical challenges of developing and conveying public health guidance under twin conditions of …

Qualitative Analysis Of Cancer Care Experiences Among Rural Cancer Survivors And Caregivers, Kendra L. Ratnapradipa, Jordan Ranta, Krishtee Napit, Lady Beverly Luma, Tamara Robinson, Danae Dinkel, Laura Schabloske, Shinobu Watanabe-Galloway

Journal Articles: Epidemiology

PURPOSE: Rural (vs urban) patients experience poorer cancer outcomes and are less likely to be engaged in cancer prevention, such as screening. As part of a community needs assessment, we explored rural cancer survivors' and caregivers' experiences, perceptions, and attitudes toward cancer care services.

METHODS: We conducted 3 focus groups (N = 20) in Spring 2021 in rural Nebraska.

FINDINGS: Three patterns of cancer diagnosis were regular care/screening without noticeable symptoms, treatment for symptoms not initially identified as cancer related, and symptom self-identification. Most participants, regardless of how diagnosis was made, had positive experiences with timely referral for testing (imaging …

Patterns Of Interdisciplinary Collaboration Resemble Biogeochemical Relationships In The Mcmurdo Dry Valleys, Antarctica: A Historical Social Network Analysis Of Science, 1907–2016, Stephen M. Chignell, Adrian Howkins, Poppie Gullett, Andrew G. Fountain

Geology Faculty Publications and Presentations

Co-authorship networks can provide key insights into the production of scientific knowledge. This is particularly interesting in Antarctica, where most human activity relates to scientific research. Bibliometric studies of Antarctic science have provided a useful understanding of international and interdisciplinary collaboration, yet most research has focused on broad-scale analyses over recent time periods. Here, we take advantage of a ‘Goldilocks’ opportunity in the McMurdo Dry Valleys, an internationally important region of Antarctica and the largest ice-free region on the continent. The McMurdo Dry Valleys have attracted continuous and diverse scientific activity since 1958. It is a geographically confined region with …

Severe Acute Respiratory Infection-Preparedness: Protocol For A Multicenter Prospective Cohort Study Of Viral Respiratory Infections, Radu Postelnicu, Avantika Srivastava, Pavan K. Bhatraju, Mark M. Wurfelc, George L. Anesi, Martin Gonzalez, Adair Andrews, Karen Lutrick, Vishakha K. Kumar, Timothy M. Uyeki, Perren J. Cobb, Leopoldo N. Segal, David Brett-Major, Janice M. Liebler, Christopher J. Kratochvil, Vikramjit Mukherjee, M. Jana Broadhurst, Richard Lee, David Wyles, Jonathan E Sevransky, Laura Evans, Douglas Landsittel

Journal Articles: Epidemiology

OBJECTIVES: Respiratory virus infections cause significant morbidity and mortality ranging from mild uncomplicated acute respiratory illness to severe complications, such as acute respiratory distress syndrome, multiple organ failure, and death during epidemics and pandemics. We present a protocol to systematically study patients with severe acute respiratory infection (SARI), including severe acute respiratory syndrome coronavirus 2, due to respiratory viral pathogens to evaluate the natural history, prognostic biomarkers, and characteristics, including hospital stress, associated with clinical outcomes and severity.

DESIGN: Prospective cohort study.

SETTING: Multicenter cohort of patients admitted to an acute care ward or ICU from at least 15 hospitals …

Making The Equal Rights Amendment That Is Needed In The Twenty-First Century, Julie C. Suk

Faculty Scholarship

No abstract provided.

Justice Ginsburg’S Cautious Legacy For The Equal Rights Amendment, Julie C. Suk

Faculty Scholarship

History will remember the late Justice Ruth Bader Ginsburg (RBG) as the “founding mother” of constitutional gender equality in the United States. This Article unpacks her legacy for inclusive constitutional change, unearthing her lifelong commitment to the Equal Rights Amendment (ERA), which was adopted fifty years ago by Congress in 1972. It took nearly half a century for the Amendment to be ratified by the thirty-eight states required by Article V, with Virginia becoming the last state to ratify it in 2020—the year of Justice Ginsburg’s death. Because the last three ratifications occurred decades after congressionally imposed time limits, RBG …

Efficient Generation Of Functional Hepatocytes From Human Induced Pluripotent Stem Cells For Disease Modeling And Disease Gene Discovery, Satish Kumar, Joanne E. Curran, Sarah Williams-Blangero, John Blangero

School of Medicine Publications

In vitro hepatocyte cell models are being used to study the pathogenesis of liver disease and in the discovery and preclinical stages of drug development. The culture of hepatic cell lines and primary hepatocytes as in vitro cell models has been carried out for several decades. However, hepatic cell lines (hepatic carcinoma generated or immortalized) have limited accuracy when recapitulating complex physiological functions of the liver. Additionally, primary hepatocytes sourced from human cadavers or medical biopsies are difficult to obtain due to sourcing limitations, particularly for large-scale population studies or in applications requiring large number of cells. Hepatocyte cultures differentiated …

Western Region Health & Wellness Programming Efforts: Qualitative Results From A Three-Part Listening Session, Cris L. Meier, Lily Ward, Anders Van Sandt, Sue Schneider, Riana Gayle

All Current Publications

The purpose of this project was to understand the programming efforts and experiences of Extension professionals in the Western Region of the United States. The Health and Wellness Working Group team held a series of listening sessions with a closed cohort of Extension professionals, hoping to learn from each other while also building the foundation for future collaborations and conversations about health and wellness programing in the western region.

The objectives were to understand: (1) the state of health and wellness work in the western region, including the gaps and challenges, (2) the programs that currently exist and ways that …

The 2022 Utah College Sexual Behavior Survey: Qualitative Report, Monti Douglas, Cris Meier, Julie Gast, Melissa Ferguson

All Current Publications

Purpose: The purpose of the 2022 Utah College Sexual Behavior Survey project was to use retrospective sexual behavior and education measures to gain a better understanding of the sexual behaviors and perceptions of sex education of Utah youth by asking students aged 18-21 years old about their sexual behaviors as youth. This supplement provides additional qualitative research that aids in understanding our quantitative findings.

Measures: The qualitative survey questions represented three topical areas. These areas included questions about consent, sex education satisfaction, and student’s parental preference when discussing topics about sex and health.

Method: A one-time survey …

Gender, Science, And The Natural World: Essays On Medieval Literature From The 2020 Gender And Medieval Studies Conference, Linda E. Mitchell, Daisy E. Black

Medieval Feminist Forum: A Journal of Gender and Sexuality

Introduction to the special issue of literature articles from the 2020 Gender and Medieval Studies Conference.

Thereby Hangs A Tail: Creation And Procreation In Medieval Werewolf Romances, Vicki Blud

Medieval Feminist Forum: A Journal of Gender and Sexuality

How do you make a werewolf? Moreover, who makes a werewolf, and why? In medieval romance, the latter questions are often the more pressing, since the transformation of man into wolf is connected less with lunar phases than with human interference—especially the intervention of an unfaithful wife. Following in the pawprints of Marie de France’s lai of Bisclavret, these romances are noted for their “courtly” wolves and antifeminist slant, but they also offer unusual perspectives on procreation. While in Aristotelian thought the generative principle was broadly associated with the male partner, the male werewolf of medieval romance is most often …

Abduction And Feminine Expression In Sir Orfeo, Ruth Worgan

Medieval Feminist Forum: A Journal of Gender and Sexuality

This article provides a new, queer feminist reading of Sir Orfeo, in which Dame Heurodis facilitates her abduction by the Fairy King in order to destabilize the patriarchal possession of her body. Using Luce Irigaray’s work on the exchange of women between men, I discuss Heurodis’s value as a commodity and how she extricates herself from this position. Irigaray proposes that the primeval patriarchy created an exclusive between-men discourse within society, a consequence of which is the consuming masculine gaze. I consider how the silencing of the feminine is akin to the silence of the natural world, and how …

“Let Him Walk With You”: Telling Stories About Fifteenth-Century Men, And The Women They Left Behind, Rachel E. Moss

Medieval Feminist Forum: A Journal of Gender and Sexuality

In this article I use a blend of autoethnography and historical storytelling to explore the role of outdoor space in forming relationships between fifteenth-century men and their maintenance of hegemonic power. By weaving together three striking vignettes from late fifteenth-century England, constructed as creative retellings of the historical evidence, with autoethnographic notes on my own lived experience, I am able to fill in the gaps of the historical record and open up questions about the implications of what has been left out. I argue that the medieval cultural understanding of the outdoors as both spiritually and physically beneficial, as well …

Female Desire In Chaucer’S “Legend Of Good Women” And Medieval English Romance, Suzanne M. Edwards

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Byzantine Intersectionality: Sexuality, Gender, And Race In The Middle Ages, C. Libby

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Christine De Pizan, “The God Of Love’S Letter” And “The Tale Of The Rose”, Roberta Krueger

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Medieval Women, Material Culture, And Power: Matilda Plantagenet And Her Sisters, Mary Dockray-Miller

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Trans Historical: Gender Plurality Before The Modern, Edited By Greta Lafleur, Masha Raskolnikov, And Anna Klosowska., Nat Rivkin

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Data Supporting Effects Of Uv-C Disinfection On N95 And Kn95 Filtering Facepiece Respirator Reuse, Castine A. Bernardy, James Malley

Data Catalog

UV is a proven decontamination tool for microbial pathogens, including the SARS-CoV-2 virus. Lower log inactivation was observed on FFRs than would have been predicted by aqueous-based UV dose-response data for MS-2 bacteriophage and E. coli. Results have demonstrated that FFR materials yield varying results in terms of effective disinfection in experiments conducted on KN95 and N95 face respirators. The highest inactivation for both surrogates was observed with respirator KN95 B. The respirator yielded 3 and 2.75 log inactivation for E. coli and MS-2, respectively at UV doses of 1500 mJ/cm². KN95 A yielded the lowest …

The Long Shadow Of United States V. Rosenberg: A Biographical Perspective On The Hon. Irving Robert Kaufman, Rodger D. Citron

Scholarly Works

No abstract provided.

Cafos And Surface Water Quality: Evidence From Wisconsin, Zach Raff, Andrew G. Meyer

Economics Faculty Research and Publications

Concentrated Animal Feeding Operations (CAFOs) – animal feeding operations with over 1,000 animal units in confined spaces – have proliferated over the past 30 years in the United States. CAFOs provide operational cost savings, but higher animal concentrations in confined spaces can generate external costs, e.g., non-point source water pollution. In this study, we improve on previous research designs to estimate the relationship between the growth in CAFOs and surface water quality using longitudinal data on a large spatial scale. We use a panel dataset from 1995-2017 that links CAFO intensity with nearby surface water quality readings in Wisconsin to …

Current State Of The Art In Hypoplastic Left Heart Syndrome, Aditya K Birla, Sunita Brimmer, Walker D Short, Oluyinka O Olutoye, Jason A Shar, Suriya Lalwani, Philippe Sucosky, Anitha Parthiban, Sundeep G Keswani, Christopher A Caldarone, Ravi K Birla

Faculty, Staff and Students Publications

Hypoplastic left heart syndrome (HLHS) is a complex congenital heart condition in which a neonate is born with an underdeveloped left ventricle and associated structures. Without palliative interventions, HLHS is fatal. Treatment typically includes medical management at the time of birth to maintain patency of the ductus arteriosus, followed by three palliative procedures: most commonly the Norwood procedure, bidirectional cavopulmonary shunt, and Fontan procedures. With recent advances in surgical management of HLHS patients, high survival rates are now obtained at tertiary treatment centers, though adverse neurodevelopmental outcomes remain a clinical challenge. While surgical management remains the standard of care for …

Artificial Intelligence In The Pediatric Echocardiography Laboratory: Automation, Physiology, And Outcomes, Minh B Nguyen, Olivier Villemain, Mark K Friedberg, Lasse Lovstakken, Craig G Rusin, Luc Mertens

Faculty, Staff and Students Publications

Artificial intelligence (AI) is frequently used in non-medical fields to assist with automation and decision-making. The potential for AI in pediatric cardiology, especially in the echocardiography laboratory, is very high. There are multiple tasks AI is designed to do that could improve the quality, interpretation, and clinical application of echocardiographic data at the level of the sonographer, echocardiographer, and clinician. In this state-of-the-art review, we highlight the pertinent literature on machine learning in echocardiography and discuss its applications in the pediatric echocardiography lab with a focus on automation of the pediatric echocardiogram and the use of echo data to better …

The Prevalence And Spectrum Of Reported Incidental Adrenal Abnormalities In Abdominal Computed Tomography Of Cancer Patients: The Experience Of A Comprehensive Cancer Center, Aiham Qdaisat, Sara Bedrose, Obadah Ezzeldin, Ahmed W Moawad, Sai-Ching J Yeung, Khaled M Elsayes, Mouhammed Amir Habra

Faculty, Staff and Students Publications

BACKGROUND: The increasing use of computed tomography (CT) has identified many patients with incidental adrenal lesions. Further evaluation of these lesions is often dependent on the language used in the radiology report. Compared to the general population, patients with cancer have a higher risk for adrenal abnormalities, yet data on the prevalence and type of incidental adrenal lesions reported on radiologic reports in cancer patients is limited. In this study, we aimed to determine the prevalence and nature of adrenal abnormalities as an incidental finding reported on radiology reports of cancer patients evaluated for reasons other than suspected adrenal pathology. …

Single-Port Laparoscopic Sacrospinous Ligament Suspension Via The Natural Vaginal Cavity (Svnotes) For Pelvic Prolapse: The First Feasibility Study, Yuanyuan Lyu, Huafeng Ding, Jin Ding, Yonghong Luo, Xiaoming Guan, Guantai Ni

Faculty, Staff and Students Publications

Objective

This study aims to investigate the feasibility and short-term efficacy of single-port laparoscopic-assisted transvaginal natural cavity endoscopic sacrospinous ligament suspensions (SvNOTES).

Methods

A total of 30 patients diagnosed with anterior or/and middle pelvic organ prolapse Stages III and IV underwent natural vaginal cavity (SvNOTES), and 30 patients who underwent conventional sacrospinous ligament (SSLF) were used as a control group. The operation time, blood loss, postoperative POP-Q score, length of hospital stay, and complications were compared between the two groups.

Results

The operation time for SvNOTE was (60 ± 13) min, which was longer than (30 ± 15) min for …

Integrated Microtia And Aural Atresia Management, Mai Thy Truong, Yi-Chun Carol Liu, Jocelyn Kohn, Sivakumar Chinnadurai, David A Zopf, Melissa Tribble, Paul B Tanner, Kathleen Sie, Kay W Chang

Faculty, Staff and Students Publications

OBJECTIVES: To present recommendations for the coordinated evaluation and management of the hearing and reconstructive needs of patients with microtia and aural atresia.

METHODS: A national working group of 9 experts on microtia and atresia evaluated a working document on the evaluation and treatment of patients. Treatment options for auricular reconstruction and hearing habilitation were reviewed and integrated into a coordinated care timeline.

RESULTS: Recommendations were created for children with microtia and atresia, including diagnostic considerations, surgical and non-surgical options for hearing management and auricular reconstruction, and the treatment timeline for each option. These recommendations are based on the collective …

Sarscov-2 Serostatus Amongst Vaccinated Employees At A Pediatric Hospital System, Sridevi Devaraj, Izmarie Poventud-Fuentes, Matthew Girotto, Jermaine Monroe, Julie Boom, George Delclos, James Versalovic

Faculty, Staff and Students Publications

To gain insights on the heterogeneity of immune responses to vaccination against SARS-CoV-2 and to identify factors that could make individuals vulnerable to infection due to lack of response to vaccination, our hospital started offering free voluntary post-antibody testing against the spike protein IgG for all fully vaccinated employees.

Post-vaccination response against SARS-CoV-2 was assessed using the FDA-EUA approved VITROS anti-SARS-CoV-2 IgG immunometric assay specific to the spike protein.

Out of a total of 3266 antibody tests performed in fully vaccinated Texas Children’s, 99.4% had a positive antibody response to the spike protein. From the 21 employees (0.6%) that had …

De Novo Glycine Synthesis Is Reduced In Adults With Morbid Obesity And Increases Following Bariatric Surgery, Hong Chang Tan, Jean W Hsu, E Shyong Tai, Shaji Chacko, Vieon Wu, Chun Fan Lee, Jean-Paul Kovalik, Farook Jahoor

Faculty, Staff and Students Publications

BACKGROUND: Glycine is a dietary non-essential amino acid that is low in obesity and increases following bariatric surgery. However, the exact mechanism responsible remains unclear and it is unknown whether hypoglycinemia is a cause or consequence of insulin resistance.

OBJECTIVE: Using multiple isotopically labeled tracers, we aimed to determine the underlying kinetic changes responsible for hypoglycinemia in obesity by: 1) Comparing glycine kinetics between participants with morbid obesity (BMI ≥ 32.5 kg/m

METHODS: [1,2-

RESULTS: Compared to controls, participants with morbid obesity had significantly lower plasma glycine concentrations at 163 (153-171) vs. 201 (172-227) µmol/L and significantly reduced

CONCLUSION: Hypoglycinemia …