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Adsorption Of Pb(Ii), Cu(Ii), And Ni(Ii) By A New Magnetic Schiff Base Resin: Synthesis, Characterization, And Thermal Study, Iman Saad Ali

Baghdad Science Journal

This study dealt with the preparation and analytical study of a type of chelating resin. This type of resin was distinguished by containing a ligand of the type of aromatic Schiff bases (5A-T) by reacting the aromatic amine (5-aminoisopthalic acid) with terephthaldehyde. The prepared Schiff base was identified using infrared FT-IR, 1H-NMR, 13C-NMR, and precise element analysis technology. The prepared Schiff bases were converted into azomethine-amide resin P5A-T by reacting the ligand (5A-T) with the diamines (4, 4-oxydianiline). The prepared resin was characterized using infrared spectroscopy. The study also included the preparation of magnetic zinc iron oxide (ZnFe2O4) by covalent …

Strength And Anti-Wettability Enhancement Of Double Layer Pvdf/Pmma Nanofibers Membrane By Embedding Sio2 Nanoparticles, Nawras N. Safi, Basma I. Waisi

Baghdad Science Journal

For the desalination of brine and seawater, membrane distillation (MD) is a desirable treatment method. Because of their high permeability and rejection, electrospun nanofiber membranes (ENMs) are becoming more popular in (MD) applications. Due to their unique features, superhydrophobic nanofibers have garnered much attention from scientists working to perfect high-efficiency MD membranes. In this work, a completely novel double-layer design approach for superhydrophobic membranes was proposed for water desalination using Direct Contact Membrane Distillation (DCMD). A double-layer of nonwoven nanofiber membranes was created using hydrophobic polymers via an electrospinning technique. Electrospinning created a double-layer membrane of nonwoven nanofibers utilizing hydrophobic …

Spectrophotometric Determination Of Bromhexine-Hcl By Using Prepared Silver Nanoparticles, Zainab Noori, Muna M. Khudhair

Baghdad Science Journal

In this study, a new, simple, and rapid method was developed for determining Bromhexine-HCl using silver nanoparticles. The solution of silver nanoparticles has a yellow color which has absorbency at a wavelength of 404 nm. Bromhexine was estimated through its reaction with silver nanoparticles in acidic environment at pH 5. This reaction causes the silver nanoparticles to aggregate and change the color of their colloidal solution from yellow to brown, leading to a decrease in their absorbance. The range of linearity was found to be 20-250μg mL-1, a limit of detection is equal to 18.931μg/mL and limit of quantitation is …

Synthesis And Characterization Of Caxni1-Xcr2O4 Compound And Studying The Effect Of The Dopant On Its Structural And Optical Properties, Weaam Abdulkader Akkad, Ibrahim Ismail, Adnan Kodala

Baghdad Science Journal

Ca_0.07Ni_0.93Cr₂O₄ was synthesized using solid-state method at 1000°C for 6h. Structural properties were studied by using X-ray diffraction and compared with Nickel Chromite compound (NiCr₂O₄) which was prepared at the same temperature. XRD patterns showed that Nickel Chromite compound crystallized according to the cubic pattern of the spinel structure. The value of its crystal lattice constant is a = 8.2449Å . After doping the Nickel Chromite with Calcium, the compound remained maintaining its crystalline structure without any change in the crystal structure, the value of the crystal lattice constant …

Synthesis Of Salicylaldehyde Derivatives And Evaluating Its Antimicrobial, Antifungal, And Anticorrosion Activities, Ibrahim Mamedov, Ali Khalilov

Baghdad Science Journal

Chalcones are natural, unsaturated aromatic ketones used in organic synthesis and medicine. Nevertheless, obtaining synthetic analogs and studying their reactions remains relevant. Unsaturated aromatic ketones are important substrates for synthesizing various heterocyclic compounds. The new chalcone, dihydropyrazole derivatives were synthesized based on 2-hydroxy-5-phenyldiazenyl benzaldehyde, and their structures were studied by NMR. Many metal structures fail each year due to harsh conditions, causing significant damage to the global economy. To overcome this problem, chemists are constantly researching and developing new corrosion inhibitors. The compounds under test contain nitrogen, oxygen, and sulfur atoms, which can be coordinated with metals. These types of …

Childhood Skeletal Lesions Common In Prehistory Are Present In Living Forager-Farmers And Predict Adult Markers Of Immune Function, Amy S. Anderson, Aaron Blackwell, M. Linda Sutherland, Thomas Kraft, James Sutherland, Bret Beheim, Daniel K. Cummings, Suhail Ghafoor, Paul L. Hooper, Daniel Eid Rodriguez, Andrei Irimia, Margaret Gatz, Wendy Mack, Chris Rowan, Michael Miyamoto, Kenneth Buetow, Caleb Finch, L. Samuel Wann, Adel Allam, Randall C. Thompson, Gregory Thomas, Hillard Kaplan, Jonathan Stieglitz, Benjamin Trumble, Michael D. Gurven

ESI Publications

Porous cranial lesions (cribra cranii and cribra orbitalia) are widely used by archaeologists as skeletal markers of poor child health. However, their use has not been validated with systematic data from contemporary populations, where there has been little evidence of these lesions or their health relevance. Using 375 in vivo computed tomography scans from a cohort-representative sample of adults aged 40+ years from the Bolivian Amazon, among food-limited, high-mortality forager-farmers, we identified cribra cranii on 46 (12.3%) and cribra orbitalia on 23 (6%). Cribra orbitalia was associated with several hallmarks of compromised immune function, including fewer B cells, fewer naïve …

Advancing The Upper Class E Traffic Management (Etm) Concept: Results Of Nasa’S First Etm Collaborative Evaluation With Industry Partners, Deborah L. Bakowski, Connie L. Brasil, Kevin Christian Garzon Galindo, Abhinay Tiwari, Paul U. Lee, Conrad Dang-Gabriel, Jeffrey Homola, Mark Evans

Faculty Research, Scholarly, and Creative Activity

Innovative aircraft design and emerging technologies are enabling new types of uncrewed, high-altitude long endurance (HALE) vehicles, including fixed-wing HALE vehicles and stratospheric balloons to operate above 60,000 feet. However, due to a variety of factors including the diverse performance characteristics and extended mission duration of these new vehicles, the Air Traffic Management system faces challenges in meeting the needs of this high-altitude environment. To address these challenges, the Higher Airspace (HA)/Upper Class E Traffic Management (ETM) concept proposes using a scalable, cooperative approach tailored for high-altitude operations. To evaluate the feasibility of the HA/ETM concept, NASA Ames Research Center …

Understanding The Chemical And Electronic Properties Of Sub-Monolayer Tio₂ On High Surface Area Silica For Jet Fuel Synthesis Applications, Mark A. Isaacs, Charalampos Drivas, Arthur Graf, Sasha Kroon, Santosh Kumar, Junxi Liu, Antonio Torres‐Lopez, Cameron Price, Edward Garland, Ines Lezcano‐Gonzalez, Christopher M. A. Parlett, Vannia C. Dos Santos‐Durndell, Lee J. Durndell

School of Geography, Earth and Environmental Sciences

2.5% of global carbon emissions result from air travel, underscoring the need for sustainable aviation fuels (SAF) derived from second-generation lignocellulosic biomass to enhance the green credentials of the aviation sector. This study demonstrates the first solvent-free photocatalytic conversion of furfural (FAL) and cyclopentanone (CPO) to produce 2,5-bis(2-furylmethylidene)cyclopentanone (F2Cp), a jet fuel precursor, using Ti-SBA-15 catalysts, synthesized via alkoxide grafting and controlled titanium surface coverage. Sub-monolayer titania films on SBA-15 supports are achieved with tuneable Ti content, confirmed by XPS (X-ray photoelectron spectroscopy), UPS (ultraviolet photoelectron spectroscopy), REELS (reflectance electron energy loss spectroscopy), ISS (ion scattering spectroscopy), and Raman analysis. …

Psychological Flexibility As A Mechanism Of Change In Online Act Among Adults Living With Chronic Health Conditions, Francesca M. Knudsen, Marissa L. Donahue, Korena S. Klimczak, Ty B. Aller, Michael E. Levin

Psychology Faculty Publications

Living with a chronic health condition (CHC) can negatively impact quality of life (QoL) through a complex interaction of mental health challenges, functional limitations, and disease management demands. Acceptance and Commitment Therapy (ACT) is a transdiagnostic approach that shows promise in addressing shared challenges across various CHCs by fostering psychological flexibility (PF). PF has been associated with improved QoL and functional outcomes and reduced psychological symptoms in individuals living with specific CHCs; yet its mediating role in these outcomes remains underexplored. This secondary analysis examined whether changes in PF mediated improvements in QoL, psychological symptoms, and functional impairment among individuals …

Human Development, Inequality, And Their Associations With Brain Structure Across 29 Countries, Vicente Medel, Luz M. Alliende, Richard Bethlehem, Jakob Seidlitz, Grace Ringlein, Celso Arango, Aurina Arnatkevičiūtė, Laila Asmal, Mark Bellgrove, Anderson M. Winkler

Human Genetics Publications

Background: The macro-social and environmental conditions in which people live, such as the level of a country’s development or inequality, are associated with brain-related disorders. However, the relationship between these systemic environmental factors and the brain remains unclear. We here aimed to determine the association between the level of development and inequality of a country and the brain structure of healthy adults.

Methods: We conducted a cross-sectional study pooling brain imaging (T1-based) data from 145 magnetic resonance imaging (MRI) studies in 7,962 healthy adults (4,110 women) in 29 different countries. We used a meta-regression approach to relate the brain structure …

Self-Compassion And Openness To Experience: A Meta-Analysis Of Relations, Jordan Moreno

Electronic Theses and Dissertations Archive

Abstract This meta-analysis sought to determine the overall association between self-compassion and openness to experience across the existing body of literature, as well as to add to the currently limited research on the associations between the individual subscales of self-compassion and openness to experience. A systematic search was conducted throughout several databases, including PsychINFO, ERIC, SCOPUS, and WorldCat Dissertation Search, using the following commonly used search terms: self-compassion, self compassion, Self-Compassion-Scale, open, openness, Big Five, HEXACO, and NEO.The study carefully extracted a total of 122 unique effect sizes (Pearson’s r) from 37 different samples, drawing on data from a combined …

Correctional Psychology And Training Implications: A Mixed Analysis Of Trainee Knowledge And Application Of Ethical Dilemmas In Corrections, And A Closer Look At The Experience Of Support From Generalist Training, Alyssa A. Hoyt

Electronic Theses and Dissertations Archive

Correctional psychology, a subfield of psychology, has long been comprised of its own distinct purpose, focus, and competencies. Yet correctional psychology remains unrecognized today as a formal American Psychology Association (APA) specialization. Unlike forensic psychology, without an APA specialization, and subsequent structured training standards, scholars have argued that correctional mental health professionals may be ill-prepared to navigate unique ethical dilemmas inherent to the correctional environment. The present mixed analysis study aimed to contribute to this discussion by assessing psychology trainees’ ability to respond to hypothetical ethical dilemmas in a manner consistent with correctional environments, and whether prior correctional experience/ exposure …

Specialty Grand Challenge: Existing Issues And Emerging Frontiers In Renal Endocrinology, A. T. M. Emdadul Haque, Mohammed S. Razzaque

School of Medicine Publications

We are currently in an exciting time to advance the field of renal endocrinology. There has never been a more favorable time to study the molecular and cellular mechanisms underlying renal hormone functions in physiology, pharmacology, and pathophysiology. The availability of advanced research tools provides unique opportunities to dissect the complex regulatory roles of renal hormones. The kidneys are vital organs in the human body; each one is composed of approximately one million functional nephrons. Understanding the precise roles and regulation of kidney-derived hormones and hormones that exert endocrine effects on the kidneys will help in preventing or delaying various …

Mathematical Modelling Of Green Energy Storage Capacities With Different Demand Scenarios, Muhammad Anas Maqbool, Pablo Borja Rosales, Md Jahir Rizvi, Yeaw Chu Lee

School of Engineering, Computing and Mathematics

The climate crisis has necessitated immediate and extensive research into sustainable, reliable, and cost-effective energy sources. The global energy shift has accelerated the integration of renewables with various industries and energy storage systems to address the challenges posed by the intermittent nature of renewable energy sources. The UK's hydrogen strategy and zero-emission shipping mission demonstrate promising progress, including the development of green hydrogen and green ammonia production and storage. However, renewable-hydrogen or ammonia storage systems present challenges, including determining effective storage capacity and meeting extensive energy requirements. The authors of this study have previously explored the prospects and feasibility of …

Twenty-Five Year Trend In Antipsychotic Medication Prescribing In England: Challenges And Opportunities, Rohit Shankar, Hannah Newman, David Branford, Richard Laugharne, Richard Byng

Peninsula Medical School

BackgroundAntipsychotics are primarily indicated for psychotic disorders. There is increasing concern regarding their potential overuse for other conditions.AimsTo examine the change in the number of community prescriptions and corresponding costs for antipsychotics per head of population over 25 years (1998–2022) in England.MethodThe data for 1998–2022 were obtained from two separate resources from the OpenPrescribing database: from 1998 to 2016 from their long-term trends data-set; and for 2017–2022 from the monthly medication prescribing data. The relevant British National Formulary subcategories 4.2.1 ‘antipsychotic drugs’ and 4.2.2 ‘antipsychotic depot injections’ were selected. The annual differences in prescriptions and the mean average annual increase …

Matter Of 57 Elmhurst, Llc V. New York State Div. Of Hous. & Community Renewal

All Decisions

The Appellate Division, Second Department, affirmed the Supreme Court's dismissal of a landlord's petition in an Article 78 proceeding. The court upheld a determination by the Division of Housing and Community Renewal that the landlord overcharged a tenant. The overcharge was caused by the landlord's unreasonable seven-year delay in applying rent increases. The court found that the DHCR's determination was not arbitrary and capricious, and had a rational basis in the record. The court's ruling reinforces the principle that it will not substitute its judgment for that of the DHCR when the agency's decision is well-founded.

Global Scale Assessment Of The Human-Induced Extinction Crisis Of Terrestrial Carnivores., Erik Joaquín Torres-Romero, Timothy M. Eppley, William J. Ripple, Thomas M. Newsome, Miha Krofel, Neil H. Carter, Andrés Ordiz, Tadeu G. De Oliveira, Nuria Selva, Vincenzo Penteriani

Anthropology Faculty Publications and Presentations

Human impacts on carnivores are a persistent conservation challenge worldwide. We present a global analysis showing the overlap of conservation lands and the cumulative impact of humans on the distribution ranges of 257 terrestrial carnivore species. Our findings reveal that 64% of carnivore ranges overlap with areas characterized by high human pressures. We found that Indigenous peoples' lands emerge as crucial for carnivore population viability, potentially safeguarding 26% of carnivore ranges globally, while protected and wilderness areas cover roughly 10 and 16% of carnivore ranges, respectively. These three areas combined cover 35% of the global range of carnivores. Reducing human …

Calibration Of Detectors For The Tomographic Ionized-Carbon Mapping Experiment, Tessalie A. Caze-Cortes

Theses

Observations of the intensity of the sky at millimeter (mm) wavelengths require accurate calibrations for the spectrometers to work with radio telescopes. However, calibrating is a complex and lengthy process for sensitive detectors that catch single photons. To improve efficiency in locating defective detectors and optimizing bias current, my research involves taking data from previous lab characterizations and creating an algorithm that analyzes and plots the code of all 1920 detectors. This thesis will discuss the importance of mm-wavelength intensity mapping and the questions the TIME research team aims to address. Also, a detailed description of mechanical and computational components …

The People's Rivers: Early Environmental Regulation And The Oregon State Sanitary Authority, Avery Morgan Fischer

Dissertations and Theses

The environmental movement in Oregon can trace its origins to the turn of the twentieth century, where citizen activism and initiative led to the creation of an early environmental regulatory agency, the Oregon State Sanitary Authority. This creation established that the State of Oregon had a duty to preserve, not just the navigability or usability of rivers and waterways, but the quality and purity of its water. The Oregon State Sanitary Authority played an active role in maintaining and protecting the environment as a mandate of the people, and throughout its thirty-year existence battling industrial polluters, reluctant municipalities, and disinterested …

Protecting Cultural Heritage In A Changing Climate: A Risk Assessment Model For Galleries, Libraries, Archives, And Museums In Florida, United States, Emily E. Fisher

LSU Master's Theses

The aim of this research is to develop a climate threat risk assessment scale for galleries, libraries, archives, and museums within the State of Florida. Current research neglects the localized impact of tropical cyclones, inland flash flooding, and exposure to SLR on cultural institutions. Tropical cyclone events bring in flooding, intense wind speeds, and power outages which affect these institutions. Tropical cyclone data from the National Hurricane Center are used to represent historical wind occurrence. Finally, flash flood warning data are used to represent the flooding likelihood in each county. Each threat is assessed individually across Florida counties. The range …

'There Is That Of God In All Of Us': Church, State, And Restrictive Abortion Policies, Kimsey J. Stewart

LSU Master's Theses

Unsafe abortion affects millions of women around the globe every year. Unsafe abortions are more likely to occur in countries with restrictive abortion policies. Yet, these policies persist, and the worldwide trend of liberalization of abortion laws is at risk of reversal. There is a disconcerting lack of research regarding what factors cause governments to enact, retain, and enforce restrictive abortion policies. This paper is an attempt to fill in such a gap. I theorize that countries in which the government has closer ties with religious organizations will have more restrictive abortion policies. My results indicate that this is likely …

Maternal Hyperleptinemia Alters Placental Transcriptome And Progesterone Regulation Without Affecting Early Equine Fetal Growth, Lucinda L. Thorburn

LSU Master's Theses

While consequences of equine obesity are well defined, the extent to which persistent hyperleptinemia and accompanying leptin (Lep) resistance affect the fetal-maternal environment warrants further exploration. This study compared endocrine, fetal, placental, and uterine parameters during early pregnancy (through day 70) in mares with elevated leptin versus normal leptin (NL) concentrations. Fourteen mares were classified as either NL (n = 6; Lep 0.9 ± 0.3 ng/mL), moderate leptin (ML; n = 4; Lep 3.0 ± 0.3 ng/mL), or high leptin (HL; n = 4; Lep 5.8 ± 0.7 ng/mL) based on annual plasma leptin. Mares were artificially inseminated and induced …

Evaluation Of Diy Pest Management Strategies For The German Cockroach (Blattella Germanica) In The Presence Of Vitamin K Precursors And Synthetic Amorphous Silica, Mohamed S. Shaik

LSU Master's Theses

The German cockroach, Blattella germanica (Linnaeus) is a globally distributed indoor dwelling pest of medical concern. Insecticides are the preferred method of cockroach management due to their low cost, quick action, and availability. However, after continuous use, the development of insecticide resistance has emerged as a challenge for the pest management industry to effectively eliminate German cockroaches. Integrated pest management (IPM) is a sustainable framework which includes the use of glue board traps, vacuuming, in combination with different insecticide formulations such as sprays, gel or dust baits, and insecticide rotation has been successful for the management of German cockroaches. This …

Dose Characterization Of Galactic Cosmic Rays In The Human Brain: A Phits-Based Study With A Segmented Anatomical Phantom, Shanice N. Manning

LSU Master's Theses

Astronauts aboard the International Space Station (ISS) are chronically exposed to a complex space radiation environment composed of galactic cosmic rays (GCR), solar particles, and Earth's trapped radiation. These high-energy particles interact with spacecraft shielding, producing secondary particles that can penetrate inside and deposit energy in sensitive tissues. Although animal studies have been useful in assessing space radiation risks, anatomical and physiological differences limit their applicability to human anatomy especially neuroanatomy. To address this gap, we developed a computational framework to model radiation dose distribution within the human brain using Monte Carlo simulations in Particle and Heavy Ion Transport code …

Clinical Outcomes In Patients With Schizophrenia Treated With Long-Acting Injectable Vs Oral Antipsychotics: A Naturalistic Study, Francesca Bardi, Lorenzo Moccia, Georgios D Kotzalidis, Gianluca Boggio, Andrea Brugnami, Greta Sfratta, Delfina Janiri, Gabriele Sani, Alessio Simonetti

Faculty, Staff and Students Publications

Background/Objectives: Long-acting injectable antipsychotics (LAIs) represent a significant advancement in the treatment of schizophrenia (SCZ), particularly for improving adherence and long-term outcomes. This study aimed to assess the clinical outcomes of patients receiving atypical LAIs compared to those on various oral antipsychotics over a one-year follow-up in a naturalistic setting.

Methods: Sixty patients with SCZ were subdivided in two groups, those receiving LAIs (n = 25) and those receiving oral antipsychotics (n = 35). The groups were comparable for age, gender, educational attainment, employment status, marital status, smoking habits, and baseline SCZ severity, with no differences …

Elimination Of Hiv Reservoirs Harboring Intact Proviruses, Min Li, Khanghy Truong, Suman Sharma, Baichao Sun, Min Chen, Jason T Kimata, Jin Wang

Faculty, Staff and Students Publications

Background: Human immunodeficiency virus (HIV) establishes persistent infection by integrating its proviral DNA into the host genome. While most integrated proviruses are defective, a small portion of proviruses are intact that represent a major obstacle to achieving an HIV cure. We have designed an approach for selective elimination of host cells harboring replication-competent HIV (SECH), through inhibition of autophagy and anti-apoptotic molecules during viral reactivation. However, the effects of SECH on the dynamics of intact and defective HIV provirus remain unclear.

Methods: We isolated DNA from HIV-infected samples after SECH treatments. We analyzed HIV-1 proviruses in these samples by intact …

Altered Patterning Of Neural Activity In A Neuropathology, Clarissa Hoffman, Jingheng Cheng, Rodrigo Morales, Daoyun Ji, Yuri Dabaghian

Faculty, Staff and Students Publications

The dynamics of neural circuits and their role in mediating cellular and organismal phenomena remain poorly understood, despite numerous efforts to dissect these processes through precise instantaneous measurements or longer-time averages and approximations. We use an alternative approach: we investigate these dynamics at the system's mesoscale by analyzing spike trains and waveforms. These extended activity patterns carry robust, tractable information, are highly responsive to physiological specifics, and enable detailed tracking of circuit behavior. In particular, this methodology allows for characterizing the functionality of tau-pathology-afflicted hippocampal circuits and identifying circuit-level abnormalities that are missed by through traditional analyses. In healthy mice, …

Development And Extensive Sequencing Of A Broadly-Consented Genome In A Bottle Matched Tumor-Normal Pair, Jennifer H Mcdaniel, Vaidehi Patel, Nathan D Olson, Hua-Jun He, Zhiyong He, Kenneth D Cole, Alexander A Gooden, Anthony Schmitt, Kristin Sikkink, Fritz J Sedlazeck, Harsha Doddapaneni, Shalini N Jhangiani, Donna M Muzny, Marie-Claude Gingras, Heer Mehta, Sairam Behera, Luis F Paulin, Alex R Hastie, Hung-Chun Yu, Victor Weigman, Alison Rojas, Katie Kennedy, Jamie Remington, Isai Salas-González, Mitch Sudkamp, Kelly Wiseman, Bryan R Lajoie, Shawn Levy, Miten Jain, Stuart Akeson, Giuseppe Narzisi, Zoe Steinsnyder, Catherine Reeves, Jennifer Shelton, Sarah B Kingan, Christine Lambert, Primo Baybayan, Aaron M Wenger, Ian J Mclaughlin, Aaron Adamson, Christopher Kingsley, Melanie Wescott, Young Kim, Benedict Paten, Jimin Park, Ivo Violich, Karen H Miga, Joshua Gardner, Brandy Mcnulty, Gail L Rosen, Rajiv Mccoy, Francesco Brundu, Erfan Sayyari, Konrad Scheffler, Sean Truong, Severine Catreux, Lesley Chapman Hannah, Doron Lipson, Hila Benjamin, Nika Iremadze, Ilya Soifer, Gat Krieger, Stephen Eacker, Mary Wood, Erin Cross, Greg Husar, Stephen Gross, Michael Vernich, Mikhail Kolmogorov, Tanveer Ahmad, Ayse G Keskus, Asher Bryant, Francoise Thibaud-Nissen, Jonathan Trow, Jacqueline Proszynski, Jeremy Wain Hirschberg, Krista Ryon, Christopher E Mason, Mital S Bhakta, J Zachary Sanborn, Elizabeth M Munding, Justin Wagner, Chunlin Xiao, Andrew S Liss, Justin M Zook

Faculty, Staff and Students Publications

The Genome in a Bottle Consortium (GIAB), hosted by the National Institute of Standards and Technology (NIST), is developing new matched tumor-normal samples, the first explicitly consented for public dissemination of genomic data and cell lines. Here, we describe a comprehensive genomic dataset from the first individual, HG008, including DNA from an adherent, epithelial-like pancreatic ductal adenocarcinoma (PDAC) tumor cell line and matched normal cells from duodenal and pancreatic tissues. Data for the tumor-normal matched samples comes from seventeen distinct state-of-the-art whole genome measurement technologies, including high depth short and long-read bulk whole genome sequencing (WGS), single cell WGS, Hi-C, …

Spase: Spatially Resolved Pathology Scores Using Optimal Transport On Spatial Transcriptomics Data, Mohammad Nuwaisir Rahman, Mohammed Abid Abrar, Vikram Rakesh Shaw, James F Martin, M Saifur Rahman, Md Abul Hassan Samee

Faculty, Staff and Students Publications

Pathological events often impact tissue regions in a spatial variable manner, making it challenging to identify therapeutic targets. Spatial transcriptomics (ST) is a powerful technology to map spatially variable molecular mechanisms, yet suitable analytical methods have been lacking. We introduce SPaSE (Spatially-resolved Pathology ScorE), an optimal transport-based algorithm to compare ST data from diseased and control tissues. SPaSE computes a “pathology score” for each spot in the diseased sample, quantifying the pathological impact at that spot. In post-MI (myocardial infarction) mouse hearts, these scores delineated zones that matched independent expert annotations. Modeling pathology scores from gene expression revealed signatures predictive …

Anxiety's Impact On Autism Spectrum Disorder Symtomology: An Investigation Into The Relationship Between Two Comorbities, Michaela Brown

LSU Doctoral Dissertations

Autism spectrum disorder (ASD) has been found to be frequently comorbid with many medical and psychological disorders, one of which is anxiety disorders. Research has shown that, when anxiety is present within ASD, various areas of the child’s functioning may be impacted, such as ASD symptom severity, emotional regulation skills, adaptability, social skills and daily living skills. The current study aimed to investigate this relationship of anxiety and ASD. First, within a sample of children and adolescents with ASD, the magnitude of the correlation between specific ASD symptoms parent-reported anxiety was compared to determine if certain ASD symptoms were more …