Digital Commons Network^™

Use Of The Fully Spectroscopic Pixelated Cadmium Telluride Detector For Benchtop X-Ray Fluorescence Computed Tomography, Sandun Jayarathna, Hem Moktan, Sang Hyun Cho

Faculty, Staff and Student Publications

In this work, we integrated a commercially-available fully-spectroscopic pixelated cadmium telluride (CdTe) detector system as a two-dimensional (2D) array detector into our existing benchtop cone-beam x-ray fluorescence computed tomography (XFCT) system. After integrating this detector, known as High-Energy X-ray Imaging Technology (HEXITEC), we performed quantitative imaging of gold nanoparticle (GNP) distribution in a small animal-sized phantom using our benchtop XFCT system. Owing to the upgraded detector component within our benchtop XFCT system, we were able to conduct this phantom imaging in an unprecedented manner by volumetric XFCT scans followed by XFCT image reconstruction in 3D. The current results showed that …

A Phase I, Open-Label, Dose-Escalation Study Of The Ox40 Agonist Ivuxolimab In Patients With Locally Advanced Or Metastatic Cancers, Adi Diab, Omid Hamid, John A Thompson, Willeke Ros, Ferry A L M Eskens, Toshihiko Doi, Siwen Hu-Lieskovan, Samuel J Klempner, Bishu Ganguly, Catherine Fleener, Xiao Wang, Tenshang Joh, Ken Liao, Shahram Salek-Ardakani, Carrie Turich Taylor, Jeffrey Chou, Anthony B El-Khoueiry

Faculty, Staff and Student Publications

PURPOSE: Stimulation of effector T cells is an appealing immunotherapeutic approach in oncology. OX40 (CD134) is a costimulatory receptor expressed on activated CD4

PATIENTS AND METHODS: Adult patients (

RESULTS: The most common all-causality adverse events were fatigue (46.2%), nausea (28.8%), and decreased appetite (25.0%). Of 31 treatment-related adverse events, 30 (96.8%) were grade ≤2. No dose-limiting toxicities occurred. Ivuxolimab exposure increased in a dose-proportionate manner from 0.3 to 10 mg/kg. Full peripheral blood target engagement occurred at ≥0.3 mg/kg. Three (5.8%) patients achieved a partial response, and disease control was achieved in 56% of patients. Increased CD4

CONCLUSIONS: Ivuxolimab …

Inhibition Of The Cd47-Sirpα Axis For Cancer Therapy: A Systematic Review And Meta-Analysis Of Emerging Clinical Data, Ji Son, Rodney Cheng-En Hsieh, Heather Y Lin, Kate J Krause, Ying Yuan, Amadeo B Biter, James Welsh, Michael A Curran, David S Hong

Faculty, Staff and Student Publications

CD47-SIRPα interaction acts as a "don't eat me" signal and is exploited by cancer to downregulate innate and adaptive immune surveillance. There has been intense interest to develop a mechanism of blockade, and we aimed to analyze the emerging data from early clinical trials. We performed a systematic review and meta-analysis of relevant databases and conference abstracts including clinical trials using CD47 and/or SIRPα inhibitors in cancer treatment. Nonlinear mixed models were applied for comparison of response and toxicity. We retrieved 317 articles, 24 of which were eligible. These included 771 response-evaluable patients with hematologic (47.1%) and solid tumors (52.9%). …

Impact Of Psychosocial, Behavioral And Lifestyle Factors On Subjective Cognitive Complaints And Perceived Quality Of Life In A Large Cohort Of Italian Breast Cancer Patients, Thomas West, Corrado Cavallero, Rita Ceccherini, Silva Foladore, Daniele Generali, Francesco Versace, Bruna Scaggiante

Faculty, Staff and Student Publications

The impact of psychosocial and behavioral factors on Cancer Related Cognitive Impairment manifestations is still under debate. Study's purpose is to determine the prevalence rate of cancer related cognitive impairment in a cohort of Italian breast cancer patients and to evaluate the implication of specific behavioral factors. For these purposes, a total of 233 women (106 breast cancer patients and 127 age-matched controls without oncological diagnosis) completed a questionnaire investigating cognitive functionality (FACT-Cog v3.0), sociodemographic characteristics, clinical information, psychosocial and behavioral factors (cognitive reserve, sleep quality, dietary habits, physical activity). The results indicated a higher prevalence rate of subjective cognitive …

Single-Incision Laparoscopic Splenectomy In Children With Massive Splenomegaly: A Prospective, Monocentric Pilot Study, Congjun Wang, Cheng Su, Chao Chen, Xianming Tang, Hong Wang, Wei Li, Yanqiang Li, Qiang Liu, Peng Chen, Yong Li, Yige Luo

Faculty, Staff and Student Publications

BACKGROUND: Single-incision laparoscopic splenectomy (SILS) remains a challenging procedure because of the technical difficulty. In this prospective study, we aimed to evaluate the efficacy and safety of SILS in children with massive splenomegaly.

METHODS: Pediatric patients with massive splenomegaly were recruited for SILS in a university-affiliated hospital. The data on patient demographics, clinical features, operative variables, and perioperative outcomes were collected prospectively and analyzed. According to the different surgical instruments, the patients were randomly assigned into two groups: the SILS with straight surgical instrument (SILS-S) group and the SILS with curved surgical instrument (SILS-C) group. A two-group comparative analysis was …

The Perspectives Of Former Csec On The Recruitment Process Through Online Platforms, Shawnte Beacham-Houston

Walden Dissertations and Doctoral Studies

Commercial sexual exploitation of children (CSEC) is the sexual exploitation of children for financial gain and is a billion-dollar industry. The sexual exploitation of children is a serious form of sexual abuse and a violation of their human rights. Previous research has explored sex trafficking victimization but not pathways to sexual exploitation. Current research does not explain how online activities and specific internet platforms are involved in CSEC recruitment and entry into the commercial sex trade industry. In this study, the way in which social media platforms are used to recruit children into the sex trade industry was addressed. The …

Lived Experiences Of Life Partners Of Police Officers Working In Crimes Against Children Units, Maria Beagle

Walden Dissertations and Doctoral Studies

Police stress is an ongoing concern in law enforcement; however, limited research has demonstrated how work-related stress affected life partners of police officers. According to Selye’s stress theory, the occupational demands placed on individuals can negatively impact their personal lives and their relationships. Law enforcement officers, especially those working cases that are sexual in nature, experience significant emotional distress. This study sought to examine the lived experiences of the partners of those who work in Crimes Against Children (CAC) units. CAC units include investigative evidence that has been considered traumatic. Specific examination of stress that life partners experience was conducted …

Fortitude, Spiritual Fortitude, And The Cancer Care Continuum In African American Breast Cancer Survivors, Karen Y. Boone

Walden Dissertations and Doctoral Studies

African American breast cancer survivors (AABCS) struggle with physical, emotional, psychological, spiritual, and financial challenges. Navigating these challenges can require the use of inner resources such as fortitude and spiritual fortitude. Using Folkman and Lazarus’ transactional model of stress and coping as the theoretical framework, the purpose of this study was to examine fortitude and spiritual fortitude as coping responses by African American women living with breast cancer and whether fortitude and spiritual fortitude were associated with phases of the cancer care continuum. A quantitative nonexperimental cross-sectional design was used for primary data collection that involved using Pretorius’ Fortitude Questionnaire …

Comparing The Assessment Knowledge And Self-Efficacy Of Science, Technology, Engineering, And Mathematics Faculty With Faculty From Other Disciplines, Karen Elizabeth Braley

Walden Dissertations and Doctoral Studies

Based on reported success and retention rates, there is a need to improve education in 2-year colleges for science, technology, engineering, and mathematics (STEM) majors. Instructors’ assessment knowledge and self-efficacy have not been studied in 2-year or STEM higher education. The problem addressed in this study was that scholars do not know the extent of differences in assessment knowledge and assessment self-efficacy of STEM and non-STEM faculty that could be a contributing factor in student success rates. The purpose of this quantitative study was to determine the extent of differences in STEM and non-STEM instructor assessment knowledge and self-efficacy as …

Mothers’ Perceptions Of Quality Of Life After A Prison Nursery Program, Gwendolyn D. Burke

Walden Dissertations and Doctoral Studies

AbstractRoughly 1,400 babies are born annually to incarcerated women in the United States. A few mothers keep their babies with them in a prison nursery program. Most incarcerated women return to living in a community setting. The purpose of this qualitative study was to explore the experience of mothers transitioning from a prison nursery program to a community-based program with their prison-born child and their perception of their quality of life (QOL) postincarceration. Sen’s capability approach of well-being, including a multidimensional measure of QOL, was the theoretical foundation for this study. In-depth semistructured interviews were used to explore the experience …

Obesity's Impact Among Asian Americans In Southern California, Alyssa Mae Sunga Carlos

Walden Dissertations and Doctoral Studies

Obesity continues to be an important public health issue in the United States, especially among minority populations. However, one minority group experiences the lowest obesity rate: Asian Americans. As a result, there is not much research available involving the impact of obesity and weight gain among this population. The purpose of this basic qualitative exploratory study was to improve the understanding of obesity’s impact on the Asian American population, specifically in Southern California, whose goals were to lose weight and become more informed about obesity’s impact on health. The study consisted of three main research questions. Twenty-five participants were interviewed …

Understanding Effective Parental Involvement Activities Across Ses, Monique Antoinette Carrington Young

Walden Dissertations and Doctoral Studies

Parental involvement is pivotal for impoverished middle school students to achieve academic achievement. The purpose of this study was to evaluate the relationship of parental involvement activities and academic achievement for impoverished middle school students. Epstein’s six parental involvement types was the theoretical framework for the research study. The six independent variables of parental involvement were parenting, volunteering, learning at home, decision making, communicating, and collaborating with community The relationship for each parental involvement activated to academic achievement as measured by grade point average was evaluated. A quantitative research design was applied using archival data from the U.S. Department of …

School Social Workers’ Perceptions Of Compassion Fatigue Syndrome, Gloria I. Collazo Cartagena

Walden Dissertations and Doctoral Studies

School social workers face domestic violence, trauma, social violence, and mental and emotional health problems in their work context. Indeed, compassion fatigue results from professionals’ continuous exposure to these problems. This study explored school social work professionals’ perceptions of compassion fatigue. For this, the following questions were explored:the perception of school social workers working for the Puerto Rico Department of Education about compassion fatigue.

Leadership Styles And Rn Turnover Intentions In Long-Term Care Facilities, Kelli M. Casey

Walden Dissertations and Doctoral Studies

Employee turnover is a concern for leaders in the nursing home industry because employees with turnover intentions may negatively impact the continuity of operations and strategic plans, resulting in poor quality of care for residents. Grounded in House's path-goal theory, the purpose of this quantitative, correlational study was to examine the relationship among idealized attributes, idealized behaviors, inspirational motivation, intellectual stimulation, individualized consideration, contingent reward, management by exception-active management by exception-passive, and turnover intentions in RNs. The independent variables were the subcategories of transformational and transactional leadership. The dependent variable was turnover intentions. Participants included 110 nonmanagement RNs working in …

Small Construction Business Owners’ Strategies To Reduce Voluntary Employee Turnover., Joel Chagadama

Walden Dissertations and Doctoral Studies

Voluntary employee turnover has caused considerable damage to small construction businesses, significantly affecting productivity, profitability, and sustainability. Small construction business owners who lack strategies to reduce voluntary employee turnover may lose experience and valuable knowledge among their employees, negatively impacting the team’s ability to perform. Grounded in the job embeddedness theory, the purpose of this qualitative multiple case study was to explore strategies small construction business owners use to reduce voluntary employee turnover. Participants were four successful small construction business owners in Virginia who successfully implemented strategies that reduced voluntary employee turnover by 75% over 5 years. Data were collected …

Caregiver Perceptions Of The Helping Families In Mental Health Crisis Act, Odinakachi Chigewe

Walden Dissertations and Doctoral Studies

Caregivers often experience increased stress when raising children who have a mental illness. Awareness of the various challenges caregivers face enables the offering of improved support. The Helping Families in Mental Health Crisis Act of 2016 (HR2646) improves and raises the profile of mental health within the government chart. This qualitative phenomenological study was guided by questions aimed at identifying caregiver perceptions of The Act and understanding caregiver input and opinions on the impact of this policy. Howlett’s five stream framework of the policy process and Kingdon’s multiple streams model provide the theoretical framework for this study. Individual telephonic interviews …

Experiences Of Mechanical Circulatory Support Patients With Primary Implant Education, Dawn Michelle Christensen

Walden Dissertations and Doctoral Studies

Advancement in mechanical circulatory support (MCS) device therapy has led to increased use in heart failure therapy and relies on optimized patient education for successful support. The purpose of this 3-manuscript study, guided by the Husserlian transcendental phenomenological method, was to explore the lived experiences of (a) patients with primary mechanical circulatory support education (PMCSE), (b) patients who undergo unplanned MCS implantation with PMCSE, and (c) patients who undergo planned MCS implantation with PMCSE. Eleven participants were recruited (eight planned, three unplanned) from MCS targeted social media sites and interviewed using a semistructured open-ended question format. Data were analyzed using …

Physician Authentic Leadership As Health Care Managers And Its Impact On Subordinates’ Ethical Strength, Eddie M. Christian

Walden Dissertations and Doctoral Studies

Physicians exercising the characteristics of authentic leaders may be better equipped to affect the ethical strength of health care staff and provide a vehicle for reducing corruption in the health care industry. This position suggests that physicians practicing with these particular qualities are more effective than those who are not genuine, transparent, or committed to maintaining emotional balance in their work relations. The purpose of this quantitative correlational study was to determine whether physician authentic leadership (AL) moderated the relationship between physician emotional intelligence (EI) and the moral potency of their billing and codes managers. Survey data were collected from …

The Longevity Of A Law Enforcement Career Post Critical Incident, Alyce E. Clark

Walden Dissertations and Doctoral Studies

Law enforcement officers experience traumatic events that can have an impact on their health and their career. Regardless of the continued research on police and mental health, challenges persist. The stigma is that law enforcement officers are tough and keep their emotions to themselves; however, they are human, like the community they serve. Due to possible consequences related to officers discussing having mental health problems after critical incidents, police officers may be reluctant to seek help due to backlash. Interviews were completed in a two-tier format that led to follow-up questions with surveys specifically related to alcohol and burnout found …

Work Engagement In A Changing Nonprofit Environment, Shukura Crevelle

Walden Dissertations and Doctoral Studies

Employee engagement is defined as a positive, fulfilling, work-related state of mind and describes work team members who gain a sense of connection in what they do. This has an impact on the physical, mental, and emotional health of the employee and the health of the organization. There was a need to explore contributing factors to employee engagement in a changing remote organization because there was a current gap in the literature regarding employee engagement and organizational change. The purpose of this qualitative study was to explore causes to low engagement among employees in a nonprofit organization located in the …

Parenting Style Influence On Future Criminal Behaviors Among Adopted Children In Mozambique, Neidi De Carvalho

Walden Dissertations and Doctoral Studies

Adoption is the process by which an adult legally becomes the parent of a child. This results in the child having the protection of a family and the same rights as a biological child. In Mozambique, there is a lack of research concerning the parenting practices of adoptive parents. This study was conducted to identify the parenting styles of Mozambican adoptive parents to determine if these parenting practices affect the well-being of the adopted child. In this qualitative study, data were collected through virtual interviews with four adoptive parents. Interviews were transcribed manually, and participants confirmed the accuracy of the …

Leadership Strategies To Motivate And Retain Employees In Small And Medium Enterprises, Shirley Jean Doescher

Walden Dissertations and Doctoral Studies

Organizational leaders find it challenging to determine what leadership strategies motivate and retain employees in their company, especially during a pandemic. Not knowing which leadership strategies would successfully motivate employees leads to higher turnover, less profitability, and higher costs to replace employees. Grounded in transformational leadership theory, the purpose of this multiple case study was to explore strategies corporate leaders use to motivate and retain employees in small and medium businesses (SMEs) in southeastern Wisconsin (WI). Data were collected from semi-structured interviews with eight participants from eight SMEs of southeast WI, as well as analyzing company documents. Yin’s 5-step process …

Strategies For Improving The Effectiveness Of Internal Control Processes In Nonprofit Organizations, Annie Selorm Dumoga

Walden Dissertations and Doctoral Studies

Some leaders of nonprofit organizations (NPOs) lack financial strategies to develop and implement effective internal controls for their financial health and the continuation of their organizations’ provision of humanitarian services. The failure of leaders in NPOs to implement adequate internal controls results in insolvency, the inability to pay off debts, and threatens the ability to provide needed social services. Grounded in the Committee of Sponsoring Organization's internal control integrated framework, the purpose of this qualitative multiple case study was to explore strategies NPO leaders used to develop and implement effective internal controls for their organization's financial health and ability to …

A Qualitative Examination Of Single-Parent Matriarchal Homes’ Influence On Gang Membership, Darryl Edwards

Walden Dissertations and Doctoral Studies

There is a problem in the city of Chicago. Gangs are responsible for a substantial percentage of violent crimes in most jurisdictions. This study examined how and to what extent single-parent matriarchal households influenced African American men between 18 and 25 to join gangs in Chicago. This study’s theoretical foundations were matriarchal theory and critical race theory. This qualitative study’s research design is heuristic phenomenology design. An in-depth interview method was employed using purposeful and snowball sampling of 20 participants; in-depth interviews were conducted using telephone technology. This study, which investigated the connection between being raised in a single-parent matriarchal …

The Correlation Between Staffing Hours And Nursing Home Resident Fall Rate, Nduka Ikpo Eke

Walden Dissertations and Doctoral Studies

AbstractHealthcare administrators and researchers have had the burden of determining best practice protocols that minimize falls among older adults living in nursing homes for several years. Several studies have investigated, and identified intrinsic and extrinsic factors that lead to falls among other adults and made recommendations along the lines of their findings. However, researchers are yet to establish the impact of staffing hours on nursing home resident fall rate. The purpose of this study was to determine the correlation if any, between nursing home residents fall rate and the staffing hours they receive daily from certified nursing assistants (CNAs), licensed …

The Need For Belonging For Previously Incarcerated Probationers, Alaina Elam

Walden Dissertations and Doctoral Studies

Research on offender rehabilitation has primarily focused on providing those who are incarcerated with programs and resources to mitigate the circumstances that would lead to recidivism. There is an absence of research on how the need for belonging could reduce recidivism in probationers. Recidivism remains a social problem for many U.S. communities, as those being released are not properly equipped for their transition. The purpose of this qualitative phenomenological study was to explore the lived experiences of probationers regarding their transition into their community, recidivism, and their need for belonging. As individual fulfillment and human motivation were examined, Maslow’s self-actualization …

Organizational Barriers To Effective University Student Mental Health Services, Felicia Evans-Edwards

Walden Dissertations and Doctoral Studies

This study was focused on organizational barriers to effective university student mental health services access in the department of student resources (DSR) at a for-profit university in the northeastern United States. Once such barriers are addressed, faculty may be more successful in reaching out to students needing mental health services who are not self-identifying as needing these services. The Baldrige excellence framework guided this descriptive case study to examine the organizational barriers that prevent university leadership from creating clear policies and procedures for faculty to refer students to mental health services. Data sources included interviews with the behavioral health leader …

Performance Strategies To Increase U.S. Federal Government Employees’ Productivity, Maurice Fluelling

Walden Dissertations and Doctoral Studies

The low productivity of U.S. federal government employees has a high cost. Performance management leaders who lack strategies to increase productivity in federal government employees witness significant goal failures in their organizations. Grounded in Deming’s total quality management, the purpose of this single-case study was to explore strategies federal government leaders used to increase employee productivity. The participants were three supervisors who worked in the U.S. federal government. Data were collected from semistructured interviews, annual reports, and publicly available data. Data were analyzed using thematic analysis, and four themes emerged: employee engagement, adaptable philosophies, changes in management, and continuous process …

Why A Women’S Domestic Violence Long-Term Shelter Is Needed, Markquatt Ford

Walden Dissertations and Doctoral Studies

This qualitative project provided a content analysis of primary and secondary data to do a need assessment of how a short-term shelter, a home for victims of domestic violence in Kansas City, Mo, can turn into a long-term shelter for victims of domestic violence. This organization was a short-term shelter, a not-for-profit organization that works for the positive social change and rehabilitation of female victims of domestic violence in Kansas City, Mo. The organization followed a traditional organizational model with a short-term scope of action. A long-term shelter is supposed to provide the residents with sufficient programs for recovery to …

Perceptions Of Support For Adult Students At A Community College, Holle Lynn Ford

Walden Dissertations and Doctoral Studies

Adult college students face unique challenges that can derail their dreams of completing a degree or certificate program. The problem addressed in this study was that, although postsecondary institutions in Tennessee have been tasked with equipping at least 55% of adult residents with a college degree or certificate by the year 2025, some college leaders were struggling with how to best support adult students. Guided by Maslow’s hierarchy of needs theory, the purpose of this qualitative case study was to better understand what supports were needed to best meet the needs of adult students who are completing a degree or …