Digital Commons Network^™

Roberto José Juáez, Ashton Jeffers

Latinx Civil Rights

The interview begins with a brief description of the focus of the session. Dr. Juárez discusses how he became involved in voting rights advocacy and how his family experiences led him to this path. He also explains how he continued centering civil rights expansion throughout law school and his legal career.

The Advocate (Fall 2022), Lewis & Clark Law School

The Advocate

No abstract provided.

Multiagent Chemotherapy And Stereotactic Body Radiation Therapy In Patients With Unresectable Pancreatic Adenocarcinoma: A Prospective Nonrandomized Controlled Trial, Colin S Hill, Lauren Rosati, Hao Wang, Hua-Ling Tsai, Jin He, Amy Hacker-Prietz, Daniel A Laheru, Lei Zheng, Shuchi Sehgal, Vincent Bernard, Dung T Le, Timothy M Pawlik, Matthew J Weiss, Amol K Narang, Joseph M Herman

Faculty, Staff and Student Publications

PURPOSE: In a prospective multicenter study, gemcitabine monotherapy followed by stereotactic body radiation therapy (SBRT) was well tolerated with outcomes comparable to chemoradiation for locally advanced pancreatic cancer (LAPC). Recent trials have reported improved survival with multiagent chemotherapy (MA-CTX) alone. This prospective trial explored whether SBRT could be safely delivered after MA-CTX. Herein, we report the long-term outcomes of adding SBRT after MA-CTX in LAPC patients and evaluate whether genetic profiles of specimens obtained before SBRT influence outcomes.

METHODS AND MATERIALS: This prospective nonrandomized controlled phase 2 trial enrolled 44 LAPC and 4 locally recurrent patients after multidisciplinary evaluation between …

Serglycin Is Involved In Tgf-Β Induced Epithelial-Mesenchymal Transition And Is Highly Expressed By Immune Cells In Breast Cancer Tissue, Marta Tellez-Gabriel, Xavier Tekpli, Trine M Reine, Beate Hegge, Stephanie R Nielsen, Meng Chen, Line Moi, Lisa Svartdal Normann, Lill-Tove R Busund, George A Calin, Gunhild M Mælandsmo, Maria Perander, Achilleas D Theocharis, Svein O Kolset, Erik Knutsen

Faculty, Staff and Student Publications

Serglycin is a proteoglycan highly expressed by immune cells, in which its functions are linked to storage, secretion, transport, and protection of chemokines, proteases, histamine, growth factors, and other bioactive molecules. In recent years, it has been demonstrated that serglycin is also expressed by several other cell types, such as endothelial cells, muscle cells, and multiple types of cancer cells. Here, we show that serglycin expression is upregulated in transforming growth factor beta (TGF-β) induced epithelial-mesenchymal transition (EMT). Functional studies provide evidence that serglycin plays an important role in the regulation of the transition between the epithelial and mesenchymal phenotypes, …

The Seen And The Unseen: Molecular Classification And Image Based-Analysis Of Gastrointestinal Cancers, Corina-Elena Minciuna, Mihai Tanase, Teodora Ecaterina Manuc, Stefan Tudor, Vlad Herlea, Mihnea P Dragomir, George A Calin, Catalin Vasilescu

Faculty, Staff and Student Publications

Gastrointestinal cancers account for 22.5% of cancer related deaths worldwide and represent circa 20% of all cancers. In the last decades, we have witnessed a shift from histology-based to molecular-based classifications using genomic, epigenomic, and transcriptomic data. The molecular based classification revealed new prognostic markers and may aid the therapy selection. Because of the high-costs to perform a molecular classification, in recent years immunohistochemistry-based surrogate classification were developed which permit the stratification of patients, and in parallel multiple groups developed hematoxylin and eosin whole slide image analysis for sub-classifying these entities. Hence, we are witnessing a return to an image-based …

Re-Thinking Therapeutic Development For Cns Metastatic Disease, Chantal Saberian, Michael A Davies

Faculty, Staff and Student Publications

There has been unprecedented progress in the development of systemic therapies for patients with metastatic melanoma over the last decade. There is now tremendous potential and momentum to further and markedly reduce the impact of this disease. However, developing more effective treatments for metastases to the CNS remains a critical challenge for patients with melanoma. Melanoma patients with active CNS metastases have largely been excluded from both early-phase and registration trials for all currently approved targeted and immune therapies for this disease. While this exclusion has generally been justified in clinical research due to concerns about poor prognosis, lack of …

Behavioural Immune Landscapes Of Inflammation, Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano Del Valle, Sandra D Castillo, Heidi C E Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E Smithgall, Mauro Di Pilato, Thorsten R Mempel, Pierre-Louis Tharaux, Santiago F González, Angel Ayuso-Sacido, Lai Guan Ng, Gabriel F Calvo, Iván González-Díaz, Fernando Díaz-De-María, Andrés Hidalgo

Faculty, Staff and Student Publications

Transcriptional and proteomic profiling of individual cells have revolutionized interpretation of biological phenomena by providing cellular landscapes of healthy and diseased tissues1,2. These approaches, however, do not describe dynamic scenarios in which cells continuously change their biochemical properties and downstream 'behavioural' outputs3-5. Here we used 4D live imaging to record tens to hundreds of morpho-kinetic parameters describing the dynamics of individual leukocytes at sites of active inflammation. By analysing more than 100,000 reconstructions of cell shapes and tracks over time, we obtained behavioural descriptors of individual cells and used these high-dimensional datasets to build behavioural landscapes. These landscapes recognized leukocyte …

Prediction Of Early (4-Week) Mortality In Acute Myeloid Leukemia With Intensive Chemotherapy, Koji Sasaki, Tapan Kadia, Kebede Begna, Courtney D Dinardo, Gautam Borthakur, Nicholas J Short, Nitin Jain, Naval Daver, Elias Jabbour, Guillermo Garcia-Manero, Guillermo Montalban Bravo, Lucia Masarova, Sherry Pierce, Marina Konopleva, Farhad Ravandi, Ayalew Tefferi, Hagop Kantarjian

Faculty, Staff and Student Publications

The progress with intensive chemotherapy and supportive care measures has improved survival in patients with newly diagnosed acute myeloid leukemia (AML). Given the recent development of effective low intensity therapies, an optimal decision on the therapy intensity may improve survival through the avoidance of early mortality. We reviewed the outcome of 3728 patients with newly diagnosed AML who received intensive chemotherapy between August 1980 and May 2020. Intensive chemotherapy was defined as a cumulative cytarabine dose ≥ 700 mg/m2 during induction therapy. We divided the whole cohort into a training and validation group at a 3:1 ratio. The population was …

Increasing Referral Of At-Risk Women For Genetic Counseling And Brca Testing Using A Screening Tool In A Community Breast Imaging Center, Banu K Arun, Susan K Peterson, Lilian E Sweeney, Rachel D Bluebond, Rebecca S S Tidwell, Sukh Makhnoon, Anne C Kushwaha

Faculty, Staff and Student Publications

BACKGROUND: Genetic evaluation and testing for hereditary breast and ovarian cancer (HBOC) remain suboptimal. The authors evaluated the feasibility of using a screening tool at a breast imaging center to increase HBOC assessment referrals.

METHODS: A brief questionnaire based on the National Comprehensive Cancer Network HBOC genetic counseling referral guidelines was developed and added to the standard intake forms of patients undergoing mammography at a community breast imaging center from 2012 through 2015. Patients who met the criteria in the guidelines were referred for genetic counseling.

RESULTS: A total of 34,851 patients were screened during the study period, and 1246 …

Contemporary Evidence On Colorectal Liver Metastases Ablation: Toward A Paradigm Shift In Locoregional Treatment, Yuan-Mao Lin, Reto Bale, Kristy K Brock, Bruno C Odisio

Faculty, Staff and Student Publications

Image-guided percutaneous ablation techniques represent an attractive local therapy for the treatment of colorectal liver metastases (CLM) given its low risk of severe complications, which allows for early initiation of adjuvant therapies and spare functional liver parenchyma, allowing repeated treatments at the time of recurrence. However, ablation does not consistently achieve similar oncological outcomes to surgery, with the latter being currently considered the first-line local treatment modality in international guidelines. Recent application of computer-assisted ablation planning, guidance, and intra-procedural response assessment has improved percutaneous ablation outcomes. In addition, the evolving understanding of tumor molecular profiling has brought to light several …

Genetic Studies On Mammalian Dna Methyltransferases, Jiameng Dan, Taiping Chen

Faculty, Staff and Student Publications

Cytosine methylation at the C5-position-generating 5-methylcytosine (5mC)-is a DNA modification found in many eukaryotic organisms, including fungi, plants, invertebrates, and vertebrates, albeit its levels vary greatly in different organisms. In mammals, cytosine methylation occurs predominantly in the context of CpG dinucleotides, with the majority (60-80%) of CpG sites in their genomes being methylated. DNA methylation plays crucial roles in the regulation of chromatin structure and gene expression and is essential for mammalian development. Aberrant changes in DNA methylation and genetic alterations in enzymes and regulators involved in DNA methylation are associated with various human diseases, including cancer and developmental disorders. …

A Phase I, Open-Label, Dose-Escalation Study Of The Ox40 Agonist Ivuxolimab In Patients With Locally Advanced Or Metastatic Cancers, Adi Diab, Omid Hamid, John A Thompson, Willeke Ros, Ferry A L M Eskens, Toshihiko Doi, Siwen Hu-Lieskovan, Samuel J Klempner, Bishu Ganguly, Catherine Fleener, Xiao Wang, Tenshang Joh, Ken Liao, Shahram Salek-Ardakani, Carrie Turich Taylor, Jeffrey Chou, Anthony B El-Khoueiry

Faculty, Staff and Student Publications

PURPOSE: Stimulation of effector T cells is an appealing immunotherapeutic approach in oncology. OX40 (CD134) is a costimulatory receptor expressed on activated CD4

PATIENTS AND METHODS: Adult patients (

RESULTS: The most common all-causality adverse events were fatigue (46.2%), nausea (28.8%), and decreased appetite (25.0%). Of 31 treatment-related adverse events, 30 (96.8%) were grade ≤2. No dose-limiting toxicities occurred. Ivuxolimab exposure increased in a dose-proportionate manner from 0.3 to 10 mg/kg. Full peripheral blood target engagement occurred at ≥0.3 mg/kg. Three (5.8%) patients achieved a partial response, and disease control was achieved in 56% of patients. Increased CD4

CONCLUSIONS: Ivuxolimab …

The Perspectives Of Former Csec On The Recruitment Process Through Online Platforms, Shawnte Beacham-Houston

Walden Dissertations and Doctoral Studies

Commercial sexual exploitation of children (CSEC) is the sexual exploitation of children for financial gain and is a billion-dollar industry. The sexual exploitation of children is a serious form of sexual abuse and a violation of their human rights. Previous research has explored sex trafficking victimization but not pathways to sexual exploitation. Current research does not explain how online activities and specific internet platforms are involved in CSEC recruitment and entry into the commercial sex trade industry. In this study, the way in which social media platforms are used to recruit children into the sex trade industry was addressed. The …

Lived Experiences Of Life Partners Of Police Officers Working In Crimes Against Children Units, Maria Beagle

Walden Dissertations and Doctoral Studies

Police stress is an ongoing concern in law enforcement; however, limited research has demonstrated how work-related stress affected life partners of police officers. According to Selye’s stress theory, the occupational demands placed on individuals can negatively impact their personal lives and their relationships. Law enforcement officers, especially those working cases that are sexual in nature, experience significant emotional distress. This study sought to examine the lived experiences of the partners of those who work in Crimes Against Children (CAC) units. CAC units include investigative evidence that has been considered traumatic. Specific examination of stress that life partners experience was conducted …

Fortitude, Spiritual Fortitude, And The Cancer Care Continuum In African American Breast Cancer Survivors, Karen Y. Boone

Walden Dissertations and Doctoral Studies

African American breast cancer survivors (AABCS) struggle with physical, emotional, psychological, spiritual, and financial challenges. Navigating these challenges can require the use of inner resources such as fortitude and spiritual fortitude. Using Folkman and Lazarus’ transactional model of stress and coping as the theoretical framework, the purpose of this study was to examine fortitude and spiritual fortitude as coping responses by African American women living with breast cancer and whether fortitude and spiritual fortitude were associated with phases of the cancer care continuum. A quantitative nonexperimental cross-sectional design was used for primary data collection that involved using Pretorius’ Fortitude Questionnaire …

Comparing The Assessment Knowledge And Self-Efficacy Of Science, Technology, Engineering, And Mathematics Faculty With Faculty From Other Disciplines, Karen Elizabeth Braley

Walden Dissertations and Doctoral Studies

Based on reported success and retention rates, there is a need to improve education in 2-year colleges for science, technology, engineering, and mathematics (STEM) majors. Instructors’ assessment knowledge and self-efficacy have not been studied in 2-year or STEM higher education. The problem addressed in this study was that scholars do not know the extent of differences in assessment knowledge and assessment self-efficacy of STEM and non-STEM faculty that could be a contributing factor in student success rates. The purpose of this quantitative study was to determine the extent of differences in STEM and non-STEM instructor assessment knowledge and self-efficacy as …

Mothers’ Perceptions Of Quality Of Life After A Prison Nursery Program, Gwendolyn D. Burke

Walden Dissertations and Doctoral Studies

AbstractRoughly 1,400 babies are born annually to incarcerated women in the United States. A few mothers keep their babies with them in a prison nursery program. Most incarcerated women return to living in a community setting. The purpose of this qualitative study was to explore the experience of mothers transitioning from a prison nursery program to a community-based program with their prison-born child and their perception of their quality of life (QOL) postincarceration. Sen’s capability approach of well-being, including a multidimensional measure of QOL, was the theoretical foundation for this study. In-depth semistructured interviews were used to explore the experience …

Obesity's Impact Among Asian Americans In Southern California, Alyssa Mae Sunga Carlos

Walden Dissertations and Doctoral Studies

Obesity continues to be an important public health issue in the United States, especially among minority populations. However, one minority group experiences the lowest obesity rate: Asian Americans. As a result, there is not much research available involving the impact of obesity and weight gain among this population. The purpose of this basic qualitative exploratory study was to improve the understanding of obesity’s impact on the Asian American population, specifically in Southern California, whose goals were to lose weight and become more informed about obesity’s impact on health. The study consisted of three main research questions. Twenty-five participants were interviewed …

Understanding Effective Parental Involvement Activities Across Ses, Monique Antoinette Carrington Young

Walden Dissertations and Doctoral Studies

Parental involvement is pivotal for impoverished middle school students to achieve academic achievement. The purpose of this study was to evaluate the relationship of parental involvement activities and academic achievement for impoverished middle school students. Epstein’s six parental involvement types was the theoretical framework for the research study. The six independent variables of parental involvement were parenting, volunteering, learning at home, decision making, communicating, and collaborating with community The relationship for each parental involvement activated to academic achievement as measured by grade point average was evaluated. A quantitative research design was applied using archival data from the U.S. Department of …

School Social Workers’ Perceptions Of Compassion Fatigue Syndrome, Gloria I. Collazo Cartagena

Walden Dissertations and Doctoral Studies

School social workers face domestic violence, trauma, social violence, and mental and emotional health problems in their work context. Indeed, compassion fatigue results from professionals’ continuous exposure to these problems. This study explored school social work professionals’ perceptions of compassion fatigue. For this, the following questions were explored:the perception of school social workers working for the Puerto Rico Department of Education about compassion fatigue.

Leadership Styles And Rn Turnover Intentions In Long-Term Care Facilities, Kelli M. Casey

Walden Dissertations and Doctoral Studies

Employee turnover is a concern for leaders in the nursing home industry because employees with turnover intentions may negatively impact the continuity of operations and strategic plans, resulting in poor quality of care for residents. Grounded in House's path-goal theory, the purpose of this quantitative, correlational study was to examine the relationship among idealized attributes, idealized behaviors, inspirational motivation, intellectual stimulation, individualized consideration, contingent reward, management by exception-active management by exception-passive, and turnover intentions in RNs. The independent variables were the subcategories of transformational and transactional leadership. The dependent variable was turnover intentions. Participants included 110 nonmanagement RNs working in …

Small Construction Business Owners’ Strategies To Reduce Voluntary Employee Turnover., Joel Chagadama

Walden Dissertations and Doctoral Studies

Voluntary employee turnover has caused considerable damage to small construction businesses, significantly affecting productivity, profitability, and sustainability. Small construction business owners who lack strategies to reduce voluntary employee turnover may lose experience and valuable knowledge among their employees, negatively impacting the team’s ability to perform. Grounded in the job embeddedness theory, the purpose of this qualitative multiple case study was to explore strategies small construction business owners use to reduce voluntary employee turnover. Participants were four successful small construction business owners in Virginia who successfully implemented strategies that reduced voluntary employee turnover by 75% over 5 years. Data were collected …

Caregiver Perceptions Of The Helping Families In Mental Health Crisis Act, Odinakachi Chigewe

Walden Dissertations and Doctoral Studies

Caregivers often experience increased stress when raising children who have a mental illness. Awareness of the various challenges caregivers face enables the offering of improved support. The Helping Families in Mental Health Crisis Act of 2016 (HR2646) improves and raises the profile of mental health within the government chart. This qualitative phenomenological study was guided by questions aimed at identifying caregiver perceptions of The Act and understanding caregiver input and opinions on the impact of this policy. Howlett’s five stream framework of the policy process and Kingdon’s multiple streams model provide the theoretical framework for this study. Individual telephonic interviews …

Experiences Of Mechanical Circulatory Support Patients With Primary Implant Education, Dawn Michelle Christensen

Walden Dissertations and Doctoral Studies

Advancement in mechanical circulatory support (MCS) device therapy has led to increased use in heart failure therapy and relies on optimized patient education for successful support. The purpose of this 3-manuscript study, guided by the Husserlian transcendental phenomenological method, was to explore the lived experiences of (a) patients with primary mechanical circulatory support education (PMCSE), (b) patients who undergo unplanned MCS implantation with PMCSE, and (c) patients who undergo planned MCS implantation with PMCSE. Eleven participants were recruited (eight planned, three unplanned) from MCS targeted social media sites and interviewed using a semistructured open-ended question format. Data were analyzed using …

Physician Authentic Leadership As Health Care Managers And Its Impact On Subordinates’ Ethical Strength, Eddie M. Christian

Walden Dissertations and Doctoral Studies

Physicians exercising the characteristics of authentic leaders may be better equipped to affect the ethical strength of health care staff and provide a vehicle for reducing corruption in the health care industry. This position suggests that physicians practicing with these particular qualities are more effective than those who are not genuine, transparent, or committed to maintaining emotional balance in their work relations. The purpose of this quantitative correlational study was to determine whether physician authentic leadership (AL) moderated the relationship between physician emotional intelligence (EI) and the moral potency of their billing and codes managers. Survey data were collected from …

The Longevity Of A Law Enforcement Career Post Critical Incident, Alyce E. Clark

Walden Dissertations and Doctoral Studies

Law enforcement officers experience traumatic events that can have an impact on their health and their career. Regardless of the continued research on police and mental health, challenges persist. The stigma is that law enforcement officers are tough and keep their emotions to themselves; however, they are human, like the community they serve. Due to possible consequences related to officers discussing having mental health problems after critical incidents, police officers may be reluctant to seek help due to backlash. Interviews were completed in a two-tier format that led to follow-up questions with surveys specifically related to alcohol and burnout found …

Work Engagement In A Changing Nonprofit Environment, Shukura Crevelle

Walden Dissertations and Doctoral Studies

Employee engagement is defined as a positive, fulfilling, work-related state of mind and describes work team members who gain a sense of connection in what they do. This has an impact on the physical, mental, and emotional health of the employee and the health of the organization. There was a need to explore contributing factors to employee engagement in a changing remote organization because there was a current gap in the literature regarding employee engagement and organizational change. The purpose of this qualitative study was to explore causes to low engagement among employees in a nonprofit organization located in the …

Parenting Style Influence On Future Criminal Behaviors Among Adopted Children In Mozambique, Neidi De Carvalho

Walden Dissertations and Doctoral Studies

Adoption is the process by which an adult legally becomes the parent of a child. This results in the child having the protection of a family and the same rights as a biological child. In Mozambique, there is a lack of research concerning the parenting practices of adoptive parents. This study was conducted to identify the parenting styles of Mozambican adoptive parents to determine if these parenting practices affect the well-being of the adopted child. In this qualitative study, data were collected through virtual interviews with four adoptive parents. Interviews were transcribed manually, and participants confirmed the accuracy of the …

Leadership Strategies To Motivate And Retain Employees In Small And Medium Enterprises, Shirley Jean Doescher

Walden Dissertations and Doctoral Studies

Organizational leaders find it challenging to determine what leadership strategies motivate and retain employees in their company, especially during a pandemic. Not knowing which leadership strategies would successfully motivate employees leads to higher turnover, less profitability, and higher costs to replace employees. Grounded in transformational leadership theory, the purpose of this multiple case study was to explore strategies corporate leaders use to motivate and retain employees in small and medium businesses (SMEs) in southeastern Wisconsin (WI). Data were collected from semi-structured interviews with eight participants from eight SMEs of southeast WI, as well as analyzing company documents. Yin’s 5-step process …

Strategies For Improving The Effectiveness Of Internal Control Processes In Nonprofit Organizations, Annie Selorm Dumoga

Walden Dissertations and Doctoral Studies

Some leaders of nonprofit organizations (NPOs) lack financial strategies to develop and implement effective internal controls for their financial health and the continuation of their organizations’ provision of humanitarian services. The failure of leaders in NPOs to implement adequate internal controls results in insolvency, the inability to pay off debts, and threatens the ability to provide needed social services. Grounded in the Committee of Sponsoring Organization's internal control integrated framework, the purpose of this qualitative multiple case study was to explore strategies NPO leaders used to develop and implement effective internal controls for their organization's financial health and ability to …