Digital Commons Network^™

The Interrelationship Between Treatment, Ethnicity, And Structured Exercise In Clinical Populations, Amanda M. F. Lopez

University of the Pacific Theses and Dissertations

Cancer is the second leading cause of death, with about approximately 1.9 million Americans being diagnosed each year. Yet, it has high survival rates with the help of advancing treatments like radiation therapy. Cancer patients and survivors are contingent on experiencing a decline in physical functioning, quality of life, and physiological parameters. Treatment is effective and can prolong life expectancy but can be deleterious to a patient’s health. Parallel with cancer's impact on Americans is cardiovascular disease. Cardiovascular disease is responsible for 1 in 4 deaths. The development of cardiovascular disease is not spread accordantly among all ethnicities. Hispanics are …

Self-Care Practices And Burnout Experiences Of Music Therapists In A Metropolitan City, Sylvester Sroka

University of the Pacific Theses and Dissertations

This thesis examined a phenomenological inquiry into the lived experiences of music therapists in a metropolitan city in the United States. During the study, five music therapists were interviewed about their self-care practices and experiences with burnout. Data included a recorded Zoom transcription of the 30–45-minute open-ended interview. The data was analyzed through Moustakas’ (1994) cluster of themes approach. Four themes emerged from the data analyses of the interviews: living/working in a metropolitan city, self-care practices, advice for entry level music therapists, and knowledge of and experience with burnout symptoms. Respondents associated living and working in a metropolitan city with …

Comparison Of Free Versus Encapsulated Drugs On 3t3 Differentiation, Simon H. Friedrich, Gabriel Volpe

UROP Posters

The scope of this project was to design, synthesize and test targeted nanoparticles containing hydrophobic and hydrophilic drugs that promote browning in adipose tissue. For hydrophilic drugs the use of liposomes and their hydrophilic core is more useful than the PLGA nanoparticles which have hydrophobic cores. The inhibition of the FOXO1 pathway and modulation of autophagy in adipose tissue can promote browning of white adipose tissue, or an energy burning state where excess energy is burned as heat instead of stored in the cell. If successful, these drugs would offer an alternative treatment for obesity where changes to the patient's …

Observing Gravitropism In Brassica Rapa Roots, Trang Ly, Maya O'Callagham, Lan Poeschl, Adil Saeed, George Zorn

UROP Posters

The objective of this experiment is to observe the effect of gravitropism on the orientation of Brassica rapa (B. rapa) roots. Specifically, amyloplasts that reside at the bottom of root tips act as gravity sensors. As plants are disturbed from upright orientation, roots automatically grow according to the downward pull of gravity. It is hypothesized that as the angle of rotation increases, the angle of root growth is inversely proportional. Five plants containing four seeds of B. rapa were grown over the course of 10 days. Each plates, aside from the control, were rotated once 90°, 80°, and 270° to …

Understanding A Low Vitamin D State In The Context Of Covid-19, James Bernard Walsh, Daniel Mccartney, Eamon Laird, Kevin Mccarroll, Declan G. Byrne, Martin Healy, Paul O'Shea, Rose Anne Kenny, John L. Faul

Articles

While a low vitamin D state has been associated with an increased risk of infection by SARS-CoV-2 in addition to an increased severity of COVID-19 disease, a causal role is not yet established. Here, we review the evidence relating to i) vitamin D and its role in SARS-CoV-2 infection and COVID-19 disease ii) the vitamin D status in the Irish adult population iii) the use of supplemental vitamin D to treat a deficient status and iv) the application of the Bradford-Hill causation criteria. We conclude that reverse causality probably makes a minimal contribution to the presence of low vitamin D …

Development And Validation Of A New Methodological Platform To Measure Behavioral, Cognitive, And Physiological Responses To Food Interventions In Real Time, M.A. Vargas-Alvarez, H. Al-Sehaim, J.M. Brunstrom, G. Castelnuovo, S. Navas-Carretero, J.A. Martínez, E. Almiron-Roig

Articles

To fully understand the causes and mechanisms involved in overeating and obesity, measures of both cognitive and physiological determinants of eating behavior need to be integrated. Effectively synchronizing behavioral measures such as meal micro-structure (e.g., eating speed), cognitive processing of sensory stimuli, and metabolic parameters, can be complex. However, this step is central to understanding the impact of food interventions on body weight. In this paper, we provide an overview of the existing gaps in eating behavior research and describe the development and validation of a new methodological platform to address some of these issues. As part of a controlled …

A Qualitative Analysis Of A Caregivers’ Experience Of Complementary Feeding In A Population Of Native Hawaiian, Other Pacific Islander And Filipino Infants: The Timing Of The Introduction Of Complementary Foods, And The Role Of Transgenerational Experience, Kara Mulville, Jessie Kai, John Kearney, Jacqueline Ng-Osorio, Carol J. Boushey, Marie K. Fialkowski

Articles

The aim of this study was to investigate caregivers’ experiences of complementary feeding (CF) among the Native Hawaiian and Other Pacific Islander (NHPI), and Filipino populations. Research focused on the timing of CF commencement, and the influence of transgenerational experience on feeding practices. The experiences and practices of those who fed human milk exclusively (HME), were compared to those who included infant formula (F&HM). Caregivers of a subset of 32 infants who were participating in a larger longitudinal study relating to CF and diet diversity, took part in voluntary in-depth interviews relating to CF practices. Interviews were recorded and transcribed. …

Bioactive Peptides From Algae: Traditional And Novel Generation Strategies, Structure-Function Relationships, And Bioinformatics As Predictive Tools For Bioactivity, Jack O'Connor, Marco Garcia-Vaquero, Steve Meaney, Brijesh Kumar Tiwari

Articles

Over the last decade, algae have been explored as alternative and sustainable protein sources for a balanced diet and more recently, as a potential source of algal-derived bioactive peptides with potential health benefits. This review will focus on the emerging processes for the generation and isolation of bioactive peptides or cryptides from algae, including: (1) pre-treatments of algae for the extraction of protein by physical and biochemical methods; and (2) methods for the generation of bioactive including enzymatic hydrolysis and other emerging methods. To date, the main biological properties of the peptides identified from algae, including anti-hypertensive, antioxidant and antiproliferative/ …

Ecological Factors And Childhood Eating Behaviours At 5 Years Of Age: Findings From The Rolo Longitudinal Birth Cohort Study, Anna Delahunt, Marie C. Conway, Eileen C. O’Brien, Aisling A. Geraghty, Linda M. O’Keeffe, Sharleen L. O’Reilly, Ciara M. Mcdonnell, Patricia M. Kearney, John Mehegan, Fionnuala M. Mcauliffe

Articles

Individual differences in children eating behaviours have been linked with childhood overweight and obesity. The determinants of childhood eating behaviours are influenced by a complex combination of hereditary and ecological factors. This study examines if key ecological predictors of childhood overweight; maternal socio-economic status (SES), children’s screen time, and childcare arrangements, are associated with eating behaviours in children aged 5-years-old.

Vitamin D Status And Mortality From Sars Cov-2: A Prospective Study Of Unvaccinated Caucasian Adults, Robert Barrett, Modar Youssef, Irfan Shah, Julia Ioana, Abdullah Al Lawati, Abdullah Bukhari, Suzanne Hegarty, Liam J. Cormican, Eoin Judge, Conor M. Burke, Catriona Cody, Joseph Feely, Katrina Hutchinson, William Tormey, Eoghan O’ Neill, Aoife O'Shea, Meabh Connolly, Daniel Mccartney, John L. Faul

Articles

COVID-19 and a low vitamin D state share common risk factors, which might explain why vitamin D deficiency has been linked with higher COVID-19 mortality. Moreover, measures of serum vitamin D may become lower during systemic inflammatory responses, further confounding the association via reverse causality. In this prospective study (recruited over 12 months), we examined whether the association between a low vitamin D state and in-hospital mortality due to SARS-CoV-2 pneumonia in unvaccinated subjects is explained by (i) the presence of shared risk factors (e.g., obesity, advanced age) or (ii) a reduction in serum 25(OH)D due to COVID-19 (i.e., reverse …

Feasibility And Applicability Of Evenson Sedentary Behavior Cut Points Applied To Children With And Wihtout Intellectual And Developmental Disabilities, Bethany Forseth, Paula E. Papanek, Michele Polfuss

Exercise Science Faculty Research and Publications

Aim

Sedentary behavior (SB) is widely studied as it is associated with cardiometabolic health and obesity issues. However, children with Intellectual and Developmental Disabilities (IDD) have been understudied. Accelerometers are commonly used to measure SB in typically developing populations but may be inappropriate for IDD populations due to differences in body movement and physiologic responses to the activity. The use of Evenson sedentary cut-points, created based on typically developing children, has yet to be applied and/or examined in children with IDD.

Purpose

A descriptive cross-sectional study was conducted to (1) Assess the feasibility of applying Evenson sedentary cut-points in children …

Unsexing Breastfeeding, Naomi Schoenbaum

GW Law Faculty Publications & Other Works

For half a century, constitutional sex equality doctrine has been combating harmful sex stereotypes by invalidating laws that treat women as caregivers and men as breadwinners. Yet decades after the constitutional sex equality revolution unsexed parenting roles, one area of parenting has escaped this doctrine’s exacting gaze: breastfeeding. Beginning in the 1990s in the wake of public health efforts to promote breastfeeding, a raft of laws were enacted, from insurance coverage mandates under the Affordable Care Act to workplace accommodations under the Fair Labor Standards Act, that provide substantial breastfeeding protections and benefits, but only to women. Although the sexed …

Induction Immunotherapy Followed By Thoracic Radiation Without Chemotherapy In Unresectable Stage Iii Non-Small Cell Lung Cancer: A Case Series., Srikiran Dasari, Takefumi Komiya Md

PCI Publications and Projects

OBJECTIVE: Although concurrent chemoradiation has been the standard of care for unresectable stage III non-small cell lung cancer (NSCLC) due to increased survival and decreased disease progression, patients with poor performance status cannot tolerate chemotherapy toxicity well. Durvalumab, an immune checkpoint inhibitor targeting the programmed death receptor-1 (PD-1) / programmed death-ligand 1 (PD-L1) axis, demonstrated efficacy as maintenance therapy after definitive chemoradiation. However, the role of immunotherapy in those who cannot tolerate chemoradiation is unclear.

METHODS: This retrospective case series reports adult patients with PD-L1-expressing stage III NSCLC diagnosed at Parkview Cancer Institute from 2019-2021 and treated initially with pembrolizumab …

The Short- And Long-Term Effects On The Microbiome Of Infants Who Are Exposed To Opioids In Utero, Dawson Brown-Ezell

Undergraduate Honors Theses

Introduction: The gut microbiome is believed to have a significant impact on health throughout the lifespan, and the influence of infant nutrition and other environmental factors are of particular interest in its development. The aim of this research project was to learn more about the microbiome and short chain fatty acid (SCFA) composition of toddlers of differing weights, considering birth history, environment, and diet. In East Tennessee, opioid misuse is a growing issue, and a number of participants in this study were exposed in utero. We also hoped to identify related effects on infant’s SCFA composition. Finally, it is known …

Still Awaiting Justice: An Analysis On The Impact Of Anti-Immigrant Sentiment On The Reproductive Autonomy Of Migrant Women, Annays Esperanza Yacaman

Senior Independent Study Theses

My research aims to explain the impact of anti-immigrant sentiment on the reproductive autonomy of migrant women. Legislators typically act as their constituents feel on a certain issue, so I aimed to explore how legislators responded with legislation when their constituents held higher levels of anti-immigrant sentiment, hypothesizing that this would lead to more legislation limiting the reproductive autonomy of migrant women. I explore topics of eugenics and how anti-immigrant sentiment has led to modern day eugenics.

My hypothesis did not manifest itself in the expected way, but the results do provide evidence for a causal link between legislation meant …

Impacts Of The Securitization Of Development In Colombia, Libbie Depastino

Senior Independent Study Theses

In the past few decades, political scientists have noticed a trend of actors linking the issue of development to security in order to emphasize its importance and legitimize action. This discursive act, known as securitization, transforms a lack of development into an existential threat that actors must protect against at all costs. Though scholars agree that this process of framing certain topics as security issues occurs, there is little information on what impact it may have on policy creation or policy outcomes. This study examines how the securitization of development impacts actual development outcomes. I hypothesize that securitization will cause …

Microplastics As Carrier Of Pahs Released From Oil Spills: Measuring Ingestion And Bioaccumulation Rates In Copepods, Manasi Desai

Senior Independent Study Theses

Microplastics (MP; plastics < 5mm) are a growing problem in the marine environment due to a large influx of plastics entering the marine environment through rivers, wastewater and litter from land. MP are known to adsorb nonpolar compounds in the water including polycyclic aromatic hydrocarbons (PAHs) released from oil spills. In this study, I quantified the ingestion rates of a marine copepod (Calanus finmarchicus) on clean polystyrene MP beads (12 um) and phenanthrene loaded MP beads (0.8 pg PAH pellet -1). I measured the phenanthrene load in copepods ingesting phenanthrene sorbed MPs and copepods exposed to phenanthrene only to measure the role of MP as a vector for PAHs into marine food webs. Additionally, I examined the fecal pellets to check the presence of MPs and if phenanthrene was still adsorbed to them. The results showed that microplastics do not act as vectors as there was no significant difference between the body load of phenanthrene in copepods from ingestion of PAH sorbed MPs and the body load from passive uptake of phenanthrene in solution. Copepods ate significantly lower phenanthrene loaded MP (1.81 x 104 beads cop-1 day-1) than microplastics only (2.67 x 104 beads cop-1 day-1) suggesting that copepods can reject particles based on chemical content. Accumulation of phenanthrene within the copepods (GC-MS analysis) showed individual copepods can accumulate between 3.48 to 4.11 ng of PAH which potentially can biomagnify in the marine food web upon predation. Fecal pellet analysis showed that an average of 2013 MP beads are present with a mean phenanthrene load of 0.15 pg bead-1. For the social science research, I conducted a literature review examining the current Indian plastic waste management strategies, legislations and its implementation. My results find that the Indian government over the years has progressively enacted and amended its policies to try to keep pace with the issue of plastic pollution. However, key challenges in the implementation such as poor enforcement, inadequate training for recycling lack of plastic alternatives and proper waste disposal infrastructure all contribute to the unsuccessful management of waste. Usage of plastic in road construction has shown to be a viable option in reducing plastic waste in India and also improving road conditions.

Effects Of Substrate Types On Nitrogen Removal Efficacy And Growth Of Canna Indica L., Arunothai Jampeetong, Pakawat Janyasupab

Applied Environmental Research

Constructed wetlands (CWs), a cost effective technology for wastewater treatment, consist of substrates and wetland plants, which should be selected carefully to gain highest treatment efficiency. However, studies on plant growth and responses to different types of substrates are very few. This study aims to assess the effects of substrate types on growth and root morphology of Canna indica L. and nitrogen (N) removal. Twenty-four similar sized approximately 1 month old C. indica plants were selected and grown on different substrates (gravel, pumice and biochar). All plants were supplied with a standard growth medium to which 14 mg L-1 NH4+, …

Risk Assessment Of Total Mercury (T-Hg) In Commercial Seafood Marketed In Bangkok, Thailand, Irwan Ramadhan Ritonga, Sujaree Bureekul, Penjai Sompongchaiyakul

Applied Environmental Research

Seafood is recognized as the high protein source of human consumption. However, it is hampered by mercury contamination. The objectives of this study are to determine total mercury (T-Hg) levels in edible portions of commercial seafood available in Bangkok’s supermarkets, and to evaluate the potential risks from mercury through seafood consumption. Total 32 species, including 22 fish, 4 cephalopod and 6 shellfish, were purchased from super-markets. Fish samples were dissected in 3 parts comprised of flesh, gill and viscera. While, cephalopod and shellfish were separated for edible tissues. The samples were digested in hot acid and were determined using cold-vapor …

Opinions On The Halfshell: Examining Public Perceptions Of Southern New England Aquaculture Development, Callan J. Yanoff

Open Access Master's Theses

With the recent expansion of aquaculture in New England, it has become increasingly difficult for aquaculture growers with farm proposals to advance past the permitting process due to public opposition. The substantial lack of innovative strategies for understanding and addressing the public’s perceptions of aquaculture development in the Northeast has created conflict in expanding sustainable farming. Through 15 focus group discussions during the summer of 2021, this study assesses how people who live in Rhode Island and Massachusetts think about farm design and examines their attitudes towards aquaculture impacts and governance. By identifying the general public’s preferences and perceptions, findings …

Care-Portal: A Clinician-Centered Digital Health Portal For Wearable Data Analytics, Shejar Sadhu

Open Access Master's Theses

Growth of “e-health” (electronic health) is unprecedented especially after the COVID-19 pandemic. Wearable technology such as smartwatches and smart finger rings have the capability to remotely monitor and quantify biometric and daily life activity parameters such as heart rate, body temperature, sleep, exercise, sedentary periods, and others from patients when they are in naturalistic environments such as home, school, work, and sports. This wearable technology can also be used to remotely monitor longitudinal symptomatic changes in chronic and acute conditions such as neurological and psychiatric disorders that may require some indicators of psychological stress in daily life settings. Wearable technology …

Phytochemical Analysis And Biological Evaluation Of Maple (Acer Saccharum) Sap Water, Kara Torrey

Open Access Master's Theses

Our laboratory initiated a comprehensive research program to investigate the phytochemical composition and biological effects of an ethyl acetate maple water extract (MWX), in comparison to other maple food extracts. Created by boiling and evaporating maple sap (Acer saccharum), maple syrup has become a popular alternative sweetener. The raw sap of the maple tree has been consumed by indigenous cultures for centuries, but recently, maple water products have gained the interest of consumers seeking plant derived functional beverages with added health benefits. Based on previous studies by our group, we hypothesize that maple water (and MWX) contains many …

Diving In: Learning Best Practices From Belize’S Managed Access Program Fisheries Policy, Mary Carper

Open Access Master's Theses

Belize has recently transitioned from an open access fisheries management regime to a program called Managed Access, based on a form of spatial management known as Territorial User Rights for Fishers (TURFs). Coastal communities rely on fishing activity for a variety of reasons including food and job security. Community well-being refers to the holistic definition of the human state, indicated by a variety of socioeconomic factors. This multi-strategy research with a concurrent nested design looks at a combination of interview and archival document data, along with demographics from the Statistical Institute of Belize in order to understand the impacts of …

Do Environmentally Relevant Concentrations Of Microplastics Pose A Threat To The Eastern Oyster, Crassostrea Virginica?, Hannah Haskell

Open Access Master's Theses

It is well known that microplastics are ubiquitous within the marine environment and that organisms are interacting with them. However, information on the potential impacts this pollutant may have on an organism are less well understood, especially in response to environmentally relevant microplastic concentrations The aim of this study was to determine if environmentally relevant microplastic exposure has any physiological impact on the eastern oyster, Crassostrea virginica. We exposed C. virginica to daily doses of polyester microfibers based on concentrations reported from the field (0, 2, & 95 fibers L-1) as well as a higher concentration similar to those …

Predictors Of Epi Procolon Utilization, Eric Lamy

Open Access Master's Theses

Background: According to the American Cancer Society, despite being one of the most preventable forms of cancer, colorectal cancer (CRC) is the fourth most common type of cancer and is the second leading cause of cancer-related deaths in the United States (US). The 2020 Behavioral Risk Factor Surveillance System estimates that around one quarter of the US population aged 50 to 75 and over one half of those in their early 50s remain unscreened despite being at risk. In 2016, the United State Food and Drug Administration approved a blood test for CRC screening called Epi proColon. Epi proColon …

Modeling Rhode Island Food Production Potential Under Different Production Scenarios, Nina Oberg

Open Access Master's Theses

Food sovereignty emphasizes the rights of people to have control over their food system. Relocalizing food production and limiting dependence on global industrial supply chains is necessary to increase food sovereignty in regions dominated by conventional food systems. In the US, the New England region aims to relocalize production by producing 50 percent of food consumed in the region by the year 2060. Rhode Island can contribute to this goal by expanding production and strengthening local food systems, thus serving as a model for New England and other urbanizing regions globally. For this study, a site suitability analysis was performed …

Home Grown: An Experimental Analysis Of Home-Methods Of Mold Removal On Textile Substrates, Paige Bailey

Open Access Master's Theses

When seeking information on how to clean away mold from clothing and textiles, searching the internet can lead to an overwhelming amount of confusing and vague information. A lack of reputable references and consistent measurements across methodologies makes attempting to clean textiles, valuable or not, potentially damaging to the textile itself. As such, the objective of this experiment was to select a handful of these cleaning methods and test them with the expectation that the results will contribute to reliable information on what methods could possibly work for certain textiles. It is the hope that this information will be made …

Automated Legal Guidance At Federal Agencies, Joshua D. Blank, Leigh Z. Osofsky

Faculty Publications

When individuals have questions about Federal benefits, services, and legal rules, they are increasingly seeking help from government chatbots, virtual assistants, and other automated tools. Current forms of automated legal guidance platforms include the U.S. Citizenship and Immigration Services’s “Emma,” the U.S. Department of Education’s “Aidan,” and the Internal Revenue Service’s “Interactive Tax Assistant.” Most scholars who have studied artificial intelligence and Federal government agencies have not focused on the government’s use of technology to offer guidance to the public. The absence of scholarly attention to automation as a means of communicating government guidance is an important gap in the …

The 2021 Faseb Science Research Conference On Nad Metabolism And Signaling, Vera Gorbunova, Shin-Ichiro Imai, Et Al

Open Access Publications

No abstract provided.

Epigenetic Regulation Of Human T‐Cell Leukemia Virus Gene Expression, Lee Ratner

Open Access Publications

No abstract provided.