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2022

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Two Studies Exploring The Effects Of Ageing Cohorts And Channel Usage On The Antecedents And Consequence Of Customer Satisfaction, Yongchang Chen Jun 2022

Two Studies Exploring The Effects Of Ageing Cohorts And Channel Usage On The Antecedents And Consequence Of Customer Satisfaction, Yongchang Chen

Dissertations and Theses Collection (Open Access)

A rapidly ageing customer base, and an acceleration in the adoption of self-service technologies (SST) are two major trends which are set to have an increasing impact on how companies manage and satisfy customers. While there has been a rich body of work studying the effects of ageing and SST usage on customers, research on how they might affect cumulative satisfaction appears to be limited. The ageing literature tends to focus on cognition and decision-making processes, while SST research tends to be narrowly focused on SST evaluation and adoption. Our understanding on how ageing affects how satisfied customers are with …


Maternal Socioeconomic Status And Infant Low Birth Weight: Interactions Across Generations, Kira M. Anderson Jun 2022

Maternal Socioeconomic Status And Infant Low Birth Weight: Interactions Across Generations, Kira M. Anderson

University Honors Theses

This article examines the interplay between low birth weight (LBW) and socioeconomic status (SES) across generations. Transgenerational research of LBW and SES is limited and poses certain challenges and nuances. A literature review was conducted which gathered studies that analyze both LBW and SES for two or more generations. Results of these studies are mixed, but the body of research is suggestive of patterns in which LBW and low SES may mutually exacerbate each other across generations. Furthermore, the research suggests that these patterns may be more severe among Black women. This paper calls into question the consequences that these …


Associations Between Adherence To The Dietary Approaches To Stop Hypertension (Dash) Diet And Six Glucose Homeostasis Traits In The Microbiome And Insulin Longitudinal Evaluation Study (Miles), Gautam Ramesh, Alexis C Wood, Matthew A Allison, Stephen S Rich, Elizabeth T Jensen, Yii-Der I Chen, Jerome I Rotter, Alain G Bertoni, Mark O Goodarzi Jun 2022

Associations Between Adherence To The Dietary Approaches To Stop Hypertension (Dash) Diet And Six Glucose Homeostasis Traits In The Microbiome And Insulin Longitudinal Evaluation Study (Miles), Gautam Ramesh, Alexis C Wood, Matthew A Allison, Stephen S Rich, Elizabeth T Jensen, Yii-Der I Chen, Jerome I Rotter, Alain G Bertoni, Mark O Goodarzi

Children’s Nutrition Research Center Staff Publications

Background and aims: The DASH diet conveys protection against type 2 diabetes mellitus (T2D) Via plant-based and non-plant-based recommendations. Research has not identified which glucose homeostasis pathways are improved. We examined associations between adherence to a DASH diet and six glucose homeostasis traits, probing whether associations could be attributed to the plant-based (DASH-P) and/or non-plant based (DASH-NP) components.

Methods and results: We included data from 295 adults without T2D (age 59.3 ± 9.00 years; 63.46% non-Hispanic White and 36.54% African American, self-reported race ancestry) participating in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). An oral glucose tolerance test (OGTT) …


Circadian Disruption Of Hippocampus In An Early Senescence Male Mouse Model, Jennifer A Davis, Jodi R Paul, Mugdha V Mokashi, Stefani A Yates, Daniel J Mount, Hira A Munir, Lacy K Goode, Martin E Young, David B Allison, Karen L Gamble Jun 2022

Circadian Disruption Of Hippocampus In An Early Senescence Male Mouse Model, Jennifer A Davis, Jodi R Paul, Mugdha V Mokashi, Stefani A Yates, Daniel J Mount, Hira A Munir, Lacy K Goode, Martin E Young, David B Allison, Karen L Gamble

Children’s Nutrition Research Center Staff Publications

Age-related cognitive decline and disruptions in circadian rhythms are growing problems as the average human life span increases. Multiple strains of the senescence-accelerated mouse (SAM) show reduced life span, and the SAMP8 strain in particular has been well documented to show cognitive deficits in behavior as well as a bimodal pattern of circadian locomotor activity. However, little is known about circadian regulation within the hippocampus of these strains of mice. Here we test the hypothesis that in this early senescence model, disruption of the molecular circadian clock in SAMP8 animals drives disrupted behavior and physiology. We found normal rhythms in …


The Effect Of Reduced Cp, Synthetic Amino Acid Supplemented Diets On Growth Performance And Nutrient Excretion In Wean To Finish Swine, Caitlin E Vonderohe, Kayla M Mills, Shule Liu, Matthew D Asmus, Emily R Otto-Tice, Brian T Richert, Ji-Qin Ni, John Scott Radcliffe Jun 2022

The Effect Of Reduced Cp, Synthetic Amino Acid Supplemented Diets On Growth Performance And Nutrient Excretion In Wean To Finish Swine, Caitlin E Vonderohe, Kayla M Mills, Shule Liu, Matthew D Asmus, Emily R Otto-Tice, Brian T Richert, Ji-Qin Ni, John Scott Radcliffe

Children’s Nutrition Research Center Staff Publications

Mixed sex pigs (n = 720) were placed in 12 rooms (Purdue Swine Environmental Research Building) to measure the effect of reduced crude protein (CP), amino acid (AA)-supplemented diets on growth and the carcass. Pigs were blocked by body weight (BW) and gender and allotted to room and pen (10 mixed-sex pigs/pen). Pigs were fed a nine-phase, wean-finish program. Control pigs consumed corn-soybean meal-distiller’s dried grains with solubles (DDGS) diets containing no to minimal (Met) synthetic AA. The 2X diet was formulated to meet the seventh most-limiting AA, and balanced using synthetic AAs to meet all AA needs. The …


An Exercise-Inducible Metabolite That Suppresses Feeding And Obesity, Veronica L Li, Yang He, Kévin Contrepois, Hailan Liu, Joon T Kim, Amanda L Wiggenhorn, Julia T Tanzo, Alan Sheng-Hwa Tung, Xuchao Lyu, Peter-James H Zushin, Robert S Jansen, Basil Michael, Kang Yong Loh, Andrew C Yang, Christian S Carl, Christian T Voldstedlund, Wei Wei, Stephanie M Terrell, Benjamin C Moeller, Rick M Arthur, Gareth A Wallis, Koen Van De Wetering, Andreas Stahl, Bente Kiens, Erik A Richter, Steven M Banik, Michael P Snyder, Yong Xu, Jonathan Z Long Jun 2022

An Exercise-Inducible Metabolite That Suppresses Feeding And Obesity, Veronica L Li, Yang He, Kévin Contrepois, Hailan Liu, Joon T Kim, Amanda L Wiggenhorn, Julia T Tanzo, Alan Sheng-Hwa Tung, Xuchao Lyu, Peter-James H Zushin, Robert S Jansen, Basil Michael, Kang Yong Loh, Andrew C Yang, Christian S Carl, Christian T Voldstedlund, Wei Wei, Stephanie M Terrell, Benjamin C Moeller, Rick M Arthur, Gareth A Wallis, Koen Van De Wetering, Andreas Stahl, Bente Kiens, Erik A Richter, Steven M Banik, Michael P Snyder, Yong Xu, Jonathan Z Long

Children’s Nutrition Research Center Staff Publications

Exercise confers robust protection against obesity, type 2 diabetes, and other cardiometabolic diseases.1–5 However, the molecular and cellular mechanisms that mediate the metabolic benefits of physical activity remain unclear.6 Here we show that exercise stimulates production of Lac-Phe, a blood-borne signaling metabolite that suppresses feeding and obesity. Lac-Phe biosynthesis from lactate occurs in CNDP2+ cells including immune cells, epithelial cells, and mesenchymal stem cells localized to diverse organs. In diet-induced obese mice, pharmacological elevation of circulating Lac-Phe reduces food intake without affecting movement or energy expenditure. Chronic administration of Lac-Phe decreases adiposity and body weight and …


The Hypothalamus For Whole-Body Physiology: From Metabolism To Aging, Tiemin Liu, Yong Xu, Chun-Xia Yi, Qingchun Tong, Dongsheng Cai Jun 2022

The Hypothalamus For Whole-Body Physiology: From Metabolism To Aging, Tiemin Liu, Yong Xu, Chun-Xia Yi, Qingchun Tong, Dongsheng Cai

Children’s Nutrition Research Center Staff Publications

Obesity and aging are two important epidemic factors for metabolic syndrome and many other health issues, which contribute to devastating diseases such as cardiovascular diseases, stroke and cancers. The brain plays a central role in controlling metabolic physiology in that it integrates information from other metabolic organs, sends regulatory projections and orchestrates the whole-body function. Emerging studies suggest that brain dysfunction in sensing various internal cues or processing external cues may have profound effects on metabolic and other physiological functions. This review highlights brain dysfunction linked to genetic mutations, sex, brain inflammation, microbiota, stress as causes for whole-body pathophysiology, arguing …


Cross-Lingual Adaptation For Recipe Retrieval With Mixup, Bin Zhu, Chong-Wah Ngo, Jingjing Chen, Wing-Kwong Chan Jun 2022

Cross-Lingual Adaptation For Recipe Retrieval With Mixup, Bin Zhu, Chong-Wah Ngo, Jingjing Chen, Wing-Kwong Chan

Research Collection School Of Computing and Information Systems

Cross-modal recipe retrieval has attracted research attention in recent years, thanks to the availability of large-scale paired data for training. Nevertheless, obtaining adequate recipe-image pairs covering the majority of cuisines for supervised learning is difficult if not impossible. By transferring knowledge learnt from a data-rich cuisine to a data-scarce cuisine, domain adaptation sheds light on this practical problem. Nevertheless, existing works assume recipes in source and target domains are mostly originated from the same cuisine and written in the same language. This paper studies unsupervised domain adaptation for image-to-recipe retrieval, where recipes in source and target domains are in different …


Flavor-Videos: Enhancing The Flavor Perception Of Food While Eating With Videos, Meetha Nesam James, Nimesha Ranasinghe, Anthony Tang, Lora Oehlberg Jun 2022

Flavor-Videos: Enhancing The Flavor Perception Of Food While Eating With Videos, Meetha Nesam James, Nimesha Ranasinghe, Anthony Tang, Lora Oehlberg

Research Collection School Of Computing and Information Systems

People are typically involved in different activities while eating, particularly when eating alone, such as watching television or playing games on their phones. Previous research in Human-Food Interaction (HFI) has primarily focused on studying people’s motivation and analyzing of the media content watched while eating. However, their impact on human behavioral and cognitive processes, particularly flavor perception and its attributes, remains underexplored. We present a user study to investigate the influence of six types of videos, including mukbang – a new food video genre, on flavor perceptions (taste sensations, liking, and emotions) while eating plain white rice. Our findings revealed …


Association Of Alcohol Use And Physical Activity With Body Mass Index In Mexican-Origin Adults, Natalia I Heredia, Qiong Dong, Shine Chang, Lorna H Mcneill Jun 2022

Association Of Alcohol Use And Physical Activity With Body Mass Index In Mexican-Origin Adults, Natalia I Heredia, Qiong Dong, Shine Chang, Lorna H Mcneill

Faculty, Staff and Student Publications

BACKGROUND: Studies across racial/ethnic groups indicate that physical activity (PA) and alcohol consumption are positively associated, and that alcohol consumption is negatively associated with body mass index (BMI), but this relationship is less often evaluated in Hispanics. The purpose of this study was to assess the relationships between alcohol consumption, PA, and BMI in Hispanic adults.

METHODS: In this secondary data analysis of a Mexican-American cohort, we collected self-reported PA, alcohol consumption, and demographics, and measured height and weight. Linear regression assessed the association between PA and alcohol consumption with BMI, controlling for covariates. Total sample for analyses was n …


Integrative Analysis Of Clinical And Epigenetic Biomarkers Of Mortality, Tianxiao Huan, Steve Nguyen, Elena Colicino, Carolina Ochoa-Rosales, W David Hill, Jennifer A Brody, Mette Soerensen, Yan Zhang, Antoine Baldassari, Mohamed Ahmed Elhadad, Tanaka Toshiko, Yinan Zheng, Arce Domingo-Relloso, Dong Heon Lee, Jiantao Ma, Chen Yao, Chunyu Liu, Shih-Jen Hwang, Roby Joehanes, Myriam Fornage, Jan Bressler, Joyce B J Van Meurs, Birgit Debrabant, Jonas Mengel-From, Jacob Hjelmborg, Kaare Christensen, Pantel Vokonas, Joel Schwartz, Sina A Gahrib, Nona Sotoodehnia, Colleen M Sitlani, Sonja Kunze, Christian Gieger, Annette Peters, Melanie Waldenberger, Ian J Deary, Luigi Ferrucci, Yishu Qu, Philip Greenland, Donald M Lloyd-Jones, Lifang Hou, Stefania Bandinelli, Trudy Voortman, Brenner Hermann, Andrea Baccarelli, Eric Whitsel, James S Pankow, Daniel Levy Jun 2022

Integrative Analysis Of Clinical And Epigenetic Biomarkers Of Mortality, Tianxiao Huan, Steve Nguyen, Elena Colicino, Carolina Ochoa-Rosales, W David Hill, Jennifer A Brody, Mette Soerensen, Yan Zhang, Antoine Baldassari, Mohamed Ahmed Elhadad, Tanaka Toshiko, Yinan Zheng, Arce Domingo-Relloso, Dong Heon Lee, Jiantao Ma, Chen Yao, Chunyu Liu, Shih-Jen Hwang, Roby Joehanes, Myriam Fornage, Jan Bressler, Joyce B J Van Meurs, Birgit Debrabant, Jonas Mengel-From, Jacob Hjelmborg, Kaare Christensen, Pantel Vokonas, Joel Schwartz, Sina A Gahrib, Nona Sotoodehnia, Colleen M Sitlani, Sonja Kunze, Christian Gieger, Annette Peters, Melanie Waldenberger, Ian J Deary, Luigi Ferrucci, Yishu Qu, Philip Greenland, Donald M Lloyd-Jones, Lifang Hou, Stefania Bandinelli, Trudy Voortman, Brenner Hermann, Andrea Baccarelli, Eric Whitsel, James S Pankow, Daniel Levy

Faculty, Staff and Student Publications

DNA methylation (DNAm) has been reported to be associated with many diseases and with mortality. We hypothesized that the integration of DNAm with clinical risk factors would improve mortality prediction. We performed an epigenome-wide association study of whole blood DNAm in relation to mortality in 15 cohorts (n = 15,013). During a mean follow-up of 10 years, there were 4314 deaths from all causes including 1235 cardiovascular disease (CVD) deaths and 868 cancer deaths. Ancestry-stratified meta-analysis of all-cause mortality identified 163 CpGs in European ancestry (EA) and 17 in African ancestry (AA) participants at p < 1 × 10


Understanding Implementation Strategies To Support Classroom-Based Physical Activity Approaches In Elementary Schools: A Qualitative Study, Timothy J Walker, Jacob Szeszulski, Michael C Robertson, Paula M Cuccaro, Maria E Fernandez Jun 2022

Understanding Implementation Strategies To Support Classroom-Based Physical Activity Approaches In Elementary Schools: A Qualitative Study, Timothy J Walker, Jacob Szeszulski, Michael C Robertson, Paula M Cuccaro, Maria E Fernandez

Faculty, Staff and Student Publications

BACKGROUND: Classroom-based physical activity approaches can improve children's physical activity levels during school. However, the implementation of these approaches remains a challenge. The purpose of this study was to examine implementation strategies to support the delivery of classroom-based physical activity approaches from the perspectives of elementary school staff.

METHODS: We conducted individual interviews with elementary school staff from a mid-sized school district in Texas. Interviews lasted approximately 60 min and were audio recorded and transcribed for analyses. We used directed content analysis and an iterative categorization approach to identify emerging themes related to implementation strategies.

RESULTS: We interviewed 15 participants …


The Ameliorative Effects Of Cinnamum Zeylanicum Extract On Renal Functions And Oxidative Stress Against Fluoxetine Drug In Male Rats, Nada Hashem, Nabil Abu Heakal, Huda El-Emam, Eman El-Ashry, Mona Elghareeb Jun 2022

The Ameliorative Effects Of Cinnamum Zeylanicum Extract On Renal Functions And Oxidative Stress Against Fluoxetine Drug In Male Rats, Nada Hashem, Nabil Abu Heakal, Huda El-Emam, Eman El-Ashry, Mona Elghareeb

Mansoura Veterinary Medical Journal

Objective: To determine the effects of cinnamon against fluoxetine on renal function, lipid profiles and oxidative stress. Design: Randomized controlled studyAnimals: Thirty-twoalbino ratsProcedures: Rats were allocated into four groups, control, FLX, Cin and FLX+ Cin group for 60 days. Blood samples were collected for measurement of kidney, liver function and lipid profiles. The left kidney was taken for determination of oxidative stress parameters, histopathological evaluation and detection of levels of caspase, renin and NRF2 genes. Procedures: FLX group administered fluoxetine 10 mg/kg Bwt. Cin group administered cinnamon 50 mg/kg body weight. FLX+ Cin group received fluoxetine at a concentration of …


Application Of Haccp System To Food Preparation And Services Kitchens In Mansoura University Hostels, Radwa Assy Jun 2022

Application Of Haccp System To Food Preparation And Services Kitchens In Mansoura University Hostels, Radwa Assy

Mansoura Veterinary Medical Journal

Objective: to assess to what extent the food safety principles of the Hazard Analysis Critical Control Points (HACCP) were applied at all Mansoura university hostels. Design: Descriptive study. Procedures: This was carried out through using a food safety checklist (49 attributes covering receiving, storing, preparation, cooking, holding and serving processes) and also through determining the microbiol quality of 100 samples from sterile milk, yoghurt, tabled egg and processed cheese (25 each) that were collected haphazardly from breakfast and dinner meals in Mansoura University hostels, with special reference to total bacterial and coliform count and isolation of Escherichia coli, Salmonella and …


Effect Of Vine Age And Selected Winemaking Techniques On The Sensory Profile Of Central Coast Red Wines, Isabelle Lomonaco Jun 2022

Effect Of Vine Age And Selected Winemaking Techniques On The Sensory Profile Of Central Coast Red Wines, Isabelle Lomonaco

Master's Theses

Descriptive sensory analysis is essential to understanding how differing varietals, viticultural techniques, enological techniques, vintage, regions, etc. impact the sensory characteristics found in wines. These studies analyzed the sensory impacts of vine age, whole cluster and stem addition influences, the frequency of cap management regimes, and selected fermentation variables, on 2019 Zinfandel, 2020 Syrah, 2020 Tannat, 2020 Cabernet Sauvignon, and 2021 Graciano wines respectively, from the Central Coast of California, USA. The investigation of Old vine Zinfandel indicated that these wines were defined as complex due to the wide variety of descriptors used to characterize them, having high color saturation …


Protocol For A Sequential, Prospective Meta-Analysis To Describe Coronavirus Disease 2019 (Covid-19) In The Pregnancy And Postpartum Periods, Emily R. Smith, Erin Oakley, Siran He, Rebecca Zavala, Kacey Ferguson, Gargi Wable Grandner, Ibukun-Oluwa Omolade Abejirinde, Yalda Afshar, Homa Ahmadzia, Marleen Temmerman Jun 2022

Protocol For A Sequential, Prospective Meta-Analysis To Describe Coronavirus Disease 2019 (Covid-19) In The Pregnancy And Postpartum Periods, Emily R. Smith, Erin Oakley, Siran He, Rebecca Zavala, Kacey Ferguson, Gargi Wable Grandner, Ibukun-Oluwa Omolade Abejirinde, Yalda Afshar, Homa Ahmadzia, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

We urgently need answers to basic epidemiological questions regarding SARS-CoV-2 infection in pregnant and postpartum women and its effect on their newborns. While many national registries, health facilities, and research groups are collecting relevant data, we need a collaborative and methodologically rigorous approach to better combine these data and address knowledge gaps, especially those related to rare outcomes. We propose that using a sequential, prospective meta-analysis (PMA) is the best approach to generate data for policy- and practice-oriented guidelines. As the pandemic evolves, additional studies identified retrospectively by the steering committee or through living systematic reviews will be invited to …


Integrated Multilayer Omics Reveals The Genomic, Proteomic, And Metabolic Influences Of Histidyl Dipeptides On The Heart, Keqiang Yan, Zhanlong Mei, Jingjing Zhao, Md Aminul Islam Prodhan, Detlef Obal, Kartik Katragadda, Benjamin Doelling, David Hoetker, Dheeraj Kumar Posa Jun 2022

Integrated Multilayer Omics Reveals The Genomic, Proteomic, And Metabolic Influences Of Histidyl Dipeptides On The Heart, Keqiang Yan, Zhanlong Mei, Jingjing Zhao, Md Aminul Islam Prodhan, Detlef Obal, Kartik Katragadda, Benjamin Doelling, David Hoetker, Dheeraj Kumar Posa

Internal Medicine, East Africa

Background: Histidyl dipeptides such as carnosine are present in a micromolar to millimolar range in mammalian hearts. These dipeptides facilitate glycolysis by proton buffering. They form conjugates with reactive aldehydes, such as acrolein, and attenuate myocardial ischemia-reperfusion injury. Although these dipeptides exhibit multifunctional properties, a composite understanding of their role in the myocardium is lacking.

Methods and Results: To identify histidyl dipeptide-mediated responses in the heart, we used an integrated triomics approach, which involved genome-wide RNA sequencing, global proteomics, and unbiased metabolomics to identify the effects of cardiospecific transgenic overexpression of the carnosine synthesizing enzyme, carnosine synthase (Carns), in …


Crossing The Dark And Fearful River: Monsanto, Pcbs, And Emerging Tort Theories, Keith Dornan, Jamie Hearn Jun 2022

Crossing The Dark And Fearful River: Monsanto, Pcbs, And Emerging Tort Theories, Keith Dornan, Jamie Hearn

American Indian Law Journal

guide the discussion.

Tribal, state, and city authorities are currently pursuing or have settled product liability, public nuisance, and other common law and statutory tort claims brought against Monsanto[1] for PCB contamination.[2] “Sovereign-led” litigation melds traditional plaintiff common law tort litigation with sovereign-led environmental suits and is an emerging trend in environmental law.[3] Tort claims against the manufacturers of contaminants ubiquitous in the environment give sovereigns a new angle for pursuing damages separate from a traditional statutory environmental claim under federal or state regulatory schemes, such as the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA)


Host And Gut Microbial Tryptophan Metabolism And Type 2 Diabetes: An Integrative Analysis Of Host Genetics, Diet, Gut Microbiome And Circulating Metabolites In Cohort Studies, Qibin Qi, Jun Li, Bing Yu, Jee-Young Moon, Jin C Chai, Jordi Merino, Jie Hu, Miguel Ruiz-Canela, Casey Rebholz, Zheng Wang, Mykhaylo Usyk, Guo-Chong Chen, Bianca C Porneala, Wenshuang Wang, Ngoc Quynh Nguyen, Elena V Feofanova, Megan L Grove, Thomas J Wang, Robert E Gerszten, Josée Dupuis, Jordi Salas-Salvadó, Wei Bao, David L Perkins, Martha L Daviglus, Bharat Thyagarajan, Jianwen Cai, Tao Wang, Joann E Manson, Miguel A Martínez-González, Elizabeth Selvin, Kathryn M Rexrode, Clary B Clish, Frank B Hu, James B Meigs, Rob Knight, Robert D Burk, Eric Boerwinkle, Robert C Kaplan Jun 2022

Host And Gut Microbial Tryptophan Metabolism And Type 2 Diabetes: An Integrative Analysis Of Host Genetics, Diet, Gut Microbiome And Circulating Metabolites In Cohort Studies, Qibin Qi, Jun Li, Bing Yu, Jee-Young Moon, Jin C Chai, Jordi Merino, Jie Hu, Miguel Ruiz-Canela, Casey Rebholz, Zheng Wang, Mykhaylo Usyk, Guo-Chong Chen, Bianca C Porneala, Wenshuang Wang, Ngoc Quynh Nguyen, Elena V Feofanova, Megan L Grove, Thomas J Wang, Robert E Gerszten, Josée Dupuis, Jordi Salas-Salvadó, Wei Bao, David L Perkins, Martha L Daviglus, Bharat Thyagarajan, Jianwen Cai, Tao Wang, Joann E Manson, Miguel A Martínez-González, Elizabeth Selvin, Kathryn M Rexrode, Clary B Clish, Frank B Hu, James B Meigs, Rob Knight, Robert D Burk, Eric Boerwinkle, Robert C Kaplan

Faculty, Staff and Student Publications

OBJECTIVE: Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet and gut microbiota.

METHOD: We analysed associations between circulating levels of 11 tryptophan metabolites and incident T2D in 9180 participants of diverse racial/ethnic backgrounds from five cohorts. We examined host genome-wide variants, dietary intake and gut microbiome associated with these metabolites.

RESULTS: Tryptophan, four kynurenine-pathway metabolites (kynurenine, kynurenate, xanthurenate and quinolinate) and indolelactate were positively associated with T2D risk, while indolepropionate was inversely associated with …


Statins Enhance The Chemosensitivity Of R-Chop In Diffuse Large B-Cell Lymphoma, Sushanth Gouni, Paolo Strati, Gokce Toruner, Akanksha Aradhya, Ralf Landgraf, Daniel Bilbao, Francisco Vega, Nitin Kumar Agarwal Jun 2022

Statins Enhance The Chemosensitivity Of R-Chop In Diffuse Large B-Cell Lymphoma, Sushanth Gouni, Paolo Strati, Gokce Toruner, Akanksha Aradhya, Ralf Landgraf, Daniel Bilbao, Francisco Vega, Nitin Kumar Agarwal

Faculty, Staff and Student Publications

The beneficial effect of statins on the anti-lymphoma activity of the rituximab-based chemotherapy regimen is controversial. Here, we retrospectively reviewed patients with naïve-treated advanced diffuse large B-cell lymphoma (DLBCL) receiving frontline R-CHOP, and for whom data regarding differential statins use was available at the time of initiation of treatment. We observe that patients treated with statins and R-CHOP experienced a significantly higher CR rate as compared to those who received R-CHOP only. We further show that patients receiving medium or high intensity statins and R-CHOP experienced a significantly higher CR as compared to those treated with R-CHOP. Six-year progression free …


221219 - Coös County Ac Agendas & Minutes, Cooperative Extension, Coos County Jun 2022

221219 - Coös County Ac Agendas & Minutes, Cooperative Extension, Coos County

Advisory Council

No abstract provided.


Diabetes Knowledge: What Do College Students Know, Abdoulaye Diallo, Roy K. Chen, Mohammed Mozadded Hossen, J. Luna, Diana Paz, Eva Arjona Jun 2022

Diabetes Knowledge: What Do College Students Know, Abdoulaye Diallo, Roy K. Chen, Mohammed Mozadded Hossen, J. Luna, Diana Paz, Eva Arjona

School of Rehabilitation Services & Counseling Faculty Publications

This study investigates students’ knowledge about diabetes, with a focus on academic disciplines and gender. Data were collected from 218 students enrolled at a large public university. Descriptive statistics were employed, and factorial analysis of variance (ANOVA) were performed. The results showed that, while participants seemed to have some knowledge about diabetes, they generally lacked specific content information about the disease. Female students outperformed male students in diabetes knowledge. Rehabilitation counselor educators can offer an invaluable service by covering the topic of diabetes in their courses and curricula. They can consider incorporating specific information about diabetes that can better prepare …


Mangrove Growth Promotion By Endophytic Actinobacteria And Seaweed Extract, Ameera Khalfan Salem Alkaabi Jun 2022

Mangrove Growth Promotion By Endophytic Actinobacteria And Seaweed Extract, Ameera Khalfan Salem Alkaabi

Theses

In this study, I aimed to determine the impact of the application of a commercial seaweed extract (SWE) bio-stimulant and endophytic actinobacterial isolates on growth performance and endogenous hormonal levels of mangroves. Therefore, I isolated endophytic plant growth promoting (PGP) actinobacteria (PGPA) from mangrove roots; and evaluated their potential as biological inoculants on mangrove seedlings under greenhouse and open-field nursery conditions. Seven salt tolerant isolates had the ability to produce different levels of in vitro plant growth regulators (PGRs) and 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase (ACCD), and to solubilize phosphorus. Accordingly, only one isolate, Streptomyces tubercidicus UAE1 (St), was …


The Principle Of “Harmful Contamination” Applied To Human Missions To Mars, Melissa De Zwart, Stacey Henderson, Rachel Neef Jun 2022

The Principle Of “Harmful Contamination” Applied To Human Missions To Mars, Melissa De Zwart, Stacey Henderson, Rachel Neef

Journal of Space Law

No abstract provided.


The Life Cycle Of Polyploid Giant Cancer Cells And Dormancy In Cancer: Opportunities For Novel Therapeutic Interventions, Jinsong Liu, Na Niu, Xiaoran Li, Xudong Zhang, Anil K Sood Jun 2022

The Life Cycle Of Polyploid Giant Cancer Cells And Dormancy In Cancer: Opportunities For Novel Therapeutic Interventions, Jinsong Liu, Na Niu, Xiaoran Li, Xudong Zhang, Anil K Sood

Faculty, Staff and Student Publications

Recent data suggest that most genotoxic agents in cancer therapy can lead to shock of genome and increase in cell size, which leads whole genome duplication or multiplication, formation of polyploid giant cancer cells, activation of an early embryonic program, and dedifferentiation of somatic cells. This process is achieved via the giant cell life cycle, a recently proposed mechanism for malignant transformation of somatic cells. Increase in both cell size and ploidy allows cells to completely or partially restructures the genome and develop into a blastocyst-like structure, similar to that observed in blastomere-stage embryogenesis. Although blastocyst-like structures with reprogrammed genome …


Rhizosphere-Competent Actinobacterial Isolates With Acc Deaminase Activity Alleviate Salt Stress In Tomato Plants In The Uae, Alaa Ahmed Abbas Elbadawi Jun 2022

Rhizosphere-Competent Actinobacterial Isolates With Acc Deaminase Activity Alleviate Salt Stress In Tomato Plants In The Uae, Alaa Ahmed Abbas Elbadawi

Biology Theses

Tomato (Solanum lycopersicum) is one of the most popular vegetables in the world, including the United Arab Emirates (UAE). Salinity is a global menace to plant growth and development, causing significant economic losses to tomato and other crop plants. It is well-known that 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase (ACCD) can increase plant tolerance to environmental stresses. This can be attributed to the increased activity of the enzyme ACCD, which breaks down ACC [the immediate precursor of ethylene (ET)] to ammonia and α-ketobutyrate, to lower the overproduction of ET levels in planta and to reduce the damages caused …


Does Gender Impact A Diagnosis Of Ankylosing Spondylitis?, Mark C Hwang, Martin Rozycki, David Kauffman, Theresa Arndt, Esther Yi, Michael H Weisman Jun 2022

Does Gender Impact A Diagnosis Of Ankylosing Spondylitis?, Mark C Hwang, Martin Rozycki, David Kauffman, Theresa Arndt, Esther Yi, Michael H Weisman

Faculty, Staff and Student Publications

Objective: The study objective was to explore differences in ankylosing spondylitis (AS) diagnosis experiences between men and women by examining the coding of health events over the 2 years preceding AS diagnosis.

Methods: Claims data (January 2006-April 2019) from the MarketScan databases were examined. Patients who had received two or more AS diagnoses at least 30 days apart and had at least 2 years of insurance enrollment before their first AS diagnosis were analyzed. Men were matched 1:1 to women by age, diagnosis date, insurance type, and enrollment duration. Health events (diagnosis and provider codes) were examined over 2 years …


Cultivation, Conflict, And Consumption: Food Systems In Syria, 1920–1946, Sara Pekow Jun 2022

Cultivation, Conflict, And Consumption: Food Systems In Syria, 1920–1946, Sara Pekow

Dissertations, Theses, and Capstone Projects

This dissertation examines Syria during the French Mandate using food as a primary unit of analysis. The exploration of food pushes this project beyond the boundaries of political and diplomatic histories of Syria during the French Mandate, bringing forward the hidden voices of the nonelite. Nonelites are often not visible in archives, but their absence in most written sources permits us to ascertain their experiences in studying the materials that comprised their everyday lives. The sources consulted for this work include memoirs, print media, and state archives, to name a few.

Each chapter of this dissertation follows a different link …


In Their Own Words: Perspectives On Collection Weeding From Library Employees And Teaching Faculty, Dan Broadbent, Megan Frost, Gregory M. Nelson, David Pixton Jun 2022

In Their Own Words: Perspectives On Collection Weeding From Library Employees And Teaching Faculty, Dan Broadbent, Megan Frost, Gregory M. Nelson, David Pixton

Faculty Publications

Following a Science and Engineering collection weeding project of over 350,000 print items, our research team conducted interviews with 20 library employees and 19 teaching faculty involved in the project. The purpose of the interviews was to assess the interviewees’ perspectives and feelings relating to the time required to complete the project, inter- and intra- library communication, the decision-making processes, and their personal assessment of the costs and benefits of the project. The interviewees also offered their views of the overall project’s successes and areas for improvement. Drawing from a qualitative analysis of the interviews, we provide guidance for other …


Pathways For Healing: An Online Therapeutic Support Group Program, Lisa Yvette Salazar Jun 2022

Pathways For Healing: An Online Therapeutic Support Group Program, Lisa Yvette Salazar

Loma Linda University Electronic Theses, Dissertations & Projects

Pathways for Healing: An Online Therapeutic Support Group Program (OTSG) is for women, ages 18 to 65 years old, diagnosed with chronic pelvic floor dysfunction (PFD). The program focuses on women living in Texas rural communities with limited access to mental health providers. The aim for this study is to determine if an OTSG program, utilizing narrative therapy (NT) within a biopsychosocial-spiritual lens (BPS-S) will improve overall health-related quality of life (HRQOL). Support groups are provided in English and Spanish, over the course of 12 weeks, facilitated by a licensed marriage and family therapist (LMFT) and licensed pelvic floor physical …