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Thomas Jefferson University Research - A Path To Digital Equity

Thomas Jefferson University Research Magazine

Inside this issue:

04 Editorial

05 Leadership Message

06 Global Jefferson

08 Bursts of Power

09 Antitrust Laws Don’t Hinder Foreign Investment Cancer Prediction Model Misses High-Risk Black Patients

10 Enveloping Buildings in Textiles Learning from Drowsy Flies

12 COVID Briefs

13 Jefferson by the Numbers

14 Inflecting the Narrative on African Studies

16 Journey of Adaptation

18 A Path Towards Digital Equity

24 JeffSolves: A New Way of Thinking

30 The Heart’s "Little Brain"

36 RNA like You’ve Never Seen Before

38 Online Content

Assessing The Fate Of Fatty Acid Esters Of Hydroxy Fatty Acids, Diglycerides And Monoacetyldiacylglycerides In Grilled Ruminant Meats Marinated With Unfiltered Beer-Based Marinades, Charles F. Manful, Thu H. Pham, Evan Wheeler, Muhammad Nadeem, Oludoyin A. Adigun, Nicole Walsh, Raymond H. Thomas

Journal of Food and Drug Analysis

Ruminant meats contain functional lipids including fatty acid esters of hydroxy fatty acids (FAHFA), diglycerides (DG), monoacetyldiglycerides (MAcDG) and medium chain triglycerides (McTG) whose consumption in the normal diet can confer benefits for consumer health. However, very little is known concerning how meat processing techniques such as marination and grilling affect the quantity and quality of these functional lipids in ruminant meats. We used ultra high-performance liquid chromatography coupled to high resolution accurate mass tandem mass spectrometry (UHPLC-HRAM-MS/MS) to show how grilling following marination with either India or Wheat ale unfiltered beer-based marinades affected the quantity and quality of these …

Lc-Qtof-Ms Evaluation Of Rabbit-Specific Peptide Markers For Meat Quantitation, Anna Stachniuk, Anna Kozub, Renata Czeczko, Magdalena Montowska, Emilia Fornal

Journal of Food and Drug Analysis

Ten rabbit-specific tryptic peptide markers and one marker peptide specific to both rabbit and hare were evaluated for mass signal linearity in binary meat mixtures using liquid chromatography-quadrupole time-of-flight-mass spectrometry. Seven meat mixtures containing chicken and varying percentages of rabbit (1%, 5%, 10%, 30%, 60%, 90%, and 100%) were analyzed. Additionally, the signal linearity of twelve peptide markers for chicken meat was examined. The best candidate peptides for the quantification of meat content were selected. Five of eleven peptides for rabbit meat and five of twelve peptides for chicken meat showed good linearity (R2 > 0.97). The limits of detection and …

Exosomal Proteomics In Kidney Disease: From Technical Approaches To Clinical Applications, Ageng Brahmadhi, Yung-Kun Chuang, San-Yuan Wang, Chih-Chin Kao, I-Lin Tsai

Journal of Food and Drug Analysis

Exosomes are small extracellular vesicles (sEVs) secreted from cells and have a general diameter ranging from 30~150 nm. It was reported that exosomes have essential roles in intercellular communication and can be targeted as biomarkers of disease or as therapeutic agents. Among the different techniques used for exosome investigation, the mass spectrometry-based proteomics approach has accelerated the unraveling of the molecular composition of exosomes and has contributed to improved knowledge of molecular processes in various diseases. In this review, we focused on proteomics-based studies of exosomes and clinical applications in kidney diseases. A general introduction of exosomes, isolation and characterization …

توقع نمو خميرة Debaryomyces Hansenii المسببة لفساد الأغذية وذلك باستخدام التحليل الإحصائي المتعدد العوامل, Nawaf Abukhalaf, Wafa Masoud, Ali Al-Qaisi

Palestine Technical University Research Journal

The main aim of the present study was to predict the growth of the food spoilage yeast Debaryomyces hansenii by multivariate data analysis (MVDA) using temperature, pH and NaCl concentration as growth parameters. Growth of five strains of D. hansenii (DHI,DHII, DHIII, DHIV and DHV) was measured as optical density at 620 nm (OD620) at different values of temperature, pH and NaCl concentrations. It was found that salt was the most important factor, which affects yeast growth followed by temperature. The growth of all yeast strains was reduced by increasing salt concentration and decreasing temperature. On the other hand, pH …

واقع الصحة المدرسية في مدارس محافظة الخليل الحكومية وسبل تطويرها, Hakam Hijje, Aseel Abu Zneid

Palestine Technical University Research Journal

This study aimed at investigating the status of school health in the Governorate of Hebron and the way to develop them. The study population consisted of all teacher members of the health committees and their coordinators, in Governorate of Hebron. In academic year 2017/2018, (1482) committee members. The researcher used questionnaire to collect data. The questionnaire sample was randomly stratified, and consisted of (250) members. The researcher developed (40) items questionnaire that covers the aspects of the status of school health. The study results revealed that, the degree of estimation of the teacher members of school health and the coordinators …

تأثير استخدام أنواع مختلفة من الأسمدة على نمو ونوعية الخس (Lactuca Sativa L.), Basel Natsheh, Nawaf Abukhalaf

Palestine Technical University Research Journal

The experiment was conducted during the period from March to the end of April 2019 to observe the effect of different fertilizer regimes on the growth, quality and yield of lettuce under field conditions. The experiment was consisting of four treatments as well as a control without fertilizer T1, compost T2, compost tea T3 and chemical fertilizer T4, in each treatment 50 replicates were planted. The measurements included wet and dry weight for shoot and root, plant length, and chlorophyll percentage. The study revealed that lettuce's best growth values were obtained with the use of eco-friendly organic fertilizer accompanied by …

توصيف المجتمعات البكتيرية في لحم الضأن الفلسطيني بواسطة التنميط الظاهري و تحليل جين 16s Rrna, Wafa Masoud, Mahmoud Hamdan

Palestine Technical University Research Journal

The main purpose of the present study was to isolate, identify and quantify bacteria in Palestinian fresh lamb meat. Phenotyping and 16S rRNA gene sequence analysis was used to identify bacteria present in lamb meat samples. Thirty-four bacterial isolates were obtained from 20 samples of fresh lamb meat collected from 4 meat shops in Tulkarem city in Palestine. Bacterial counts were in a range of 3 x 103 -1.5 x 105 cfu / g with Staphylococcus aureus being the highest in numbers among other bacteria. Enterobacteriaceae and Staphylococ-caceae were the predominant bacterial families detected in fresh lamb meat samples. Two …

Evaluating The Application Of The Collective Impact Model In Collaborative Health Efforts: A Case Study On Weight Of The Fox Valley, 2013-2019, Natalie J. Lamonto

Lawrence University Honors Projects

The Collective Impact (CI) Model is a relatively new collaborative model commonly used in community-based health efforts. However, there is minimal data on the effectiveness of this model in community health organizations. With the conclusion of Weight of the Fox Valley (WOTFV), a local health effort adhering to the CI Model, in 2019; I set out to examine the application of the CI Model in a real-world setting and its effectiveness in WOTFV. Through archival research and qualitative interviews with former WOTFV members, I use WOTFV as a case study of the CI Model to interpret how the model promoted …

Genetically Encoded Atp Biosensors For Direct Monitoring Of Cellular Atp Dynamics, Donnell White, Qinglin Yang

School of Medicine Faculty Publications

Adenosine 5′-triphosphate, or ATP, is the primary molecule for storing and transferring energy in cells. ATP is mainly produced via oxidative phosphorylation in mitochondria, and to a lesser extent, via glycolysis in the cytosol. In general, cytosolic glycolysis is the primary ATP producer in proliferative cells or cells subjected to hypoxia. On the other hand, mitochondria produce over 90% of cellular ATP in differentiated cells under normoxic conditions. Under pathological conditions, ATP demand rises to meet the needs of biosynthesis for cellular repair, signaling transduction for stress responses, and biochemical processes. These changes affect how mitochondria and cytosolic glycolysis function …

Nox4 Expression In Osteo-Progenitors Controls Bone Development In Mice During Early Life, Jin Ran Chen, Oxana P. Lazarenko, Michael L. Blackburn, Jennifer F. Chen, Christopher E. Randolph, Jovanny Zabaleta, Katrin Schroder, Kim B. Pedersen, Martin J.J. Ronis

School of Medicine Faculty Publications

Tightly regulated and cell-specific NADPH-oxidases (Nox) represent one of the major sources of reactive oxygen species (ROS) signaling molecules that are involved in tissue development and stem cell self-renewal. We have characterized the role of Nox4 in osteo-progenitors during postnatal bone development. Nox4 expression in bone and ROS generation were increased during early osteoblast differentiation and bone development. Stromal osteoblastic cell self-renewal, proliferation and ROS production were significantly lower in samples from whole-body Nox4 knockout mice (Nox4-/-) and conditional knockout (CKO) mice with depletion of Nox4 in the limb bud mesenchyme compared with those from control mice (Nox4fl/fl), but they …

Raising The Bar, Keith Testa

UNH Today Archive

No abstract provided.

Acute Handgrip Fatigue And Forearm Girth In Recreational Sport Rock Climbers, Grace Antoinette Macdonald, Jacob W. Manning, Nathaniel Bodell, John C. Young, Brian K. Schilling, Szu-Ping Lee, James W. Navalta

International Journal of Exercise Science

International Journal of Exercise Science 15(4): 834-845, 2022. Indoor sport rock climbing has been increasing in popularity both recreationally and competitively. Despite this increase in popularity, the physiological responses to sport climbing as an exercise to specific muscle groups are not well defined. The purpose of this study was to quantify the change in handgrip strength over a 30-minute bout of continuous climbing, specifically in intermediate-level sport climbers. Ten intermediate rock climbers (age = 27 ± 2 years; climbing experience: 7.3 ± 1.5 years) completed baseline handgrip strength and forearm girth measurements. Each participant ascended one of two 5.9 difficulty …

Lifestyle Choices And Risk Of Developing Cardiovascular Disease In College Students, Dieu-My T. Tran, Angela E. Silvestri-Elmore, Angela Sojobi

International Journal of Exercise Science

International Journal of Exercise Science 15(2): 808-819, 2022. The purpose of the study was to examine and evaluate the cardiovascular risk factors in college students including their nutritional and social choices and how those choices related to their cardiovascular health. A descriptive, cross-sectional study of 148 college students, obtaining their blood pressure, body mass index, fasting lipid panel, fasting glucose, hemoglobin A1c, serum cotinine levels, physical activity, alcohol consumption, and dietary habits. A high prevalence of cardiovascular disease risk factors was found: 23.8% were current or past smokers with more male than female smokers (p = .009); 65.5% consumed …

Creating Healthy Community In The Postindustrial City, Brian A. Hoey

Proceedings of the annual meeting of the Southern Anthropological Society

No abstract provided.

"The Revolution Will Be Community Grown": Food Justice In The Urban Agriculture Movement Of Detroit, James C. Tolleson

Proceedings of the annual meeting of the Southern Anthropological Society

No abstract provided.

State Regulation Of Chemical Abortion After Dobbs, Clarke D. Forsythe, Donna Harrison M.D.

Liberty University Law Review

No abstract provided.

The Art Of Teaching Anthropology: Examples From Biological Anthropology, Susan Kirkpatrick Smith, Laura D. Lund, Marilyn R. London

Proceedings of the annual meeting of the Southern Anthropological Society

Teaching in a college or university setting has many challenges, including often-inadequate preparation in graduate school and the requirement to develop new courses, often in a short period of time. Anthropology faculty are at a particular disadvantage because anthropology lacks any discipline-specific journals for the publication of articles on the scholarship of teaching and learning. Many anthropology faculty desire to have more resources available for course and assignment development. In this chapter, we present several examples of course syllabi, class activities, and a sample student paper that faculty can use as they develop or revise anthropology courses.

Fair Fare?: Food As Contested Terrain In U. S. Prisons And Jails, Avi Brisman

Proceedings of the annual meeting of the Southern Anthropological Society

No abstract provided.

Ramps: Appalachian Delicacies That “Smells God-Awful, But Cures What Ails Ya”, Lisa J. Lefler

Proceedings of the annual meeting of the Southern Anthropological Society

No abstract provided.

The Politics Of Traditional Foodways In The Arkansas Delta, C. Laine Gates, Justin M. Nolan, Mary Jo Schneider

Proceedings of the annual meeting of the Southern Anthropological Society

No abstract provided.

Introduction, Lisa J. Lefler

Proceedings of the annual meeting of the Southern Anthropological Society

No abstract provided.

Introduction, Robert Shanafelt

Proceedings of the annual meeting of the Southern Anthropological Society

No abstract provided.

June 13-14, 2022, Ohio University Board Of Trustees Meeting Minutes, Ohio University Board Of Trustees

Board of Trustees Meeting Minutes

Meeting minutes document the activities of Ohio University's Board of Trustees.

The Pho1;2a'-M1.1 Allele Of Phosphate1 Conditions Misregulation Of The Phosphorus Starvation Response In Maize (Zea Mays Ssp. Mays L.), Ana Laura Alonso-Nieves, M. Nancy Salazar-Vidal, J. Vladimir Torres-Rodríguez, Leonardo M. Pérez-Vázquez, Julio A. Massange-Sánchez, C. Stewart Gillmor, Ruairidh J. H. Sawers

Center for Plant Science Innovation: Faculty Publications

Plant PHO1 proteins play a central role in the translocation and sensing of inorganic phosphate. The maize (Zea mays ssp. mays) genome encodes two co-orthologs of the Arabidopsis PHO1 gene, designated ZmPho1;2a and ZmPho1;2b. Here, we report the characterization of the transposon footprint allele Zmpho1;2a'-m1.1, which we refer to hereafter as pho1;2a. The pho1;2a allele is a stable derivative formed by excision of an Activator transposable element from the ZmPho1;2a gene. The pho1;2a allele contains an 8-bp insertion at the point of transposon excision that disrupts the reading frame and is predicted to …

Examining Perceived Stress And Diet Quality Among Low-Income Families Engaged With A Nutrition-Based Food Assistance Program, Kelsey R. Wolfe, Kathryn L. Dambrino, David Phillippi, Laura Gray

DNP Projects

Abstract

Introduction: Evidence suggests poor-quality diets and high levels of stress have negative impacts on health, especially in low-income families in the southern United States. Nutrition-based food assistance programs were developed to meet nutritional needs of food insecure clients. The purpose of this scholarly project was to explore the relationship between perceived stress and diet quality among low-income families engaged with a nutrition-based food assistance program.

Methods: A retrospective and observational design was used to analyze previously collected survey responses from clients participating in a nutrition-based food assistance program in Nashville, TN (N = 425). Descriptive statistics and Spearman’s …

Improving Transition Care: A Transition Toolkit Implementation Project, Julieanne Cox, Bret Lyman, Matt Anderson, Marie Prothero

Student Works

The purpose of this project was to develop an easy-to-use transition toolkit for clinics serving children and young adults with chronic illnesses who are transitioning from a pediatric model of care to an adult model of care. GotTransition’s six core elements served as a guiding framework for the toolkit. The toolkit was developed through an iterative process with substantial stakeholder input. Stakeholders included patient, parents, clinicians, and transition care experts. Project evaluation data were gathered from clinic stakeholders using a quantitative post-then survey based on GotTransition’s six core elements of transition care, as well as three open-ended questions. All six …

Associations Of Maternal Lipoprotein Particle Distribution In Mid-Pregnancy With Birth Outcomes: A Pilot Study., Todd C. Rideout, Xiaozhong Wen, Divya Choudhary, Marissa Catanzaro, Richard W. Browne, Vanessa M. Barnabei, Kai Ling Kong

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: An excessive rise in maternal lipids during pregnancy may have detrimental impacts on maternal and fetal health leading to adverse pregnancy outcomes. However, knowledge gaps exist with respect to the association between lipid biomarkers and birth outcomes.

METHODS: We conducted a secondary data analysis of healthy pregnant women (N = 25) with mid-pregnancy fasting serum samples collected at 22-28 weeks of gestation and birth outcome data. Serum was analyzed for conventional lipid profile (total-C, HDL-C, LDL-C, and triglycerides) and lipoprotein subclass distribution, including particle number (nM) and size (nm), for very low-density lipoprotein (VLDL)/chylomicron (CM), low density lipoprotein (LDL), …

Use Of Early Specialty Hesi Exams As Predictors Of Hesi Exit Examination Performance In Baccalaureate Degree Nursing Program, Cathy E. Hansen

Dissertations

This study explored standardized testing outcomes used early in a baccalaureate nursing (BSN) education program in traditional and second-degree students in order to identify predictors of outcome on the program exit examination (HESI E²). Defining early predictors of student outcomes may more accurately identify student need for early intervention, offer timely remediation, optimize success, and minimize attrition in nursing education programs. The purpose of this correlational quantitative study was to determine if a relationship exists between student outcomes on four HESI specialty exams (fundamentals, health assessment, pathophysiology, and pharmacology) and the performance outcomes on the HESI E^{2 …}

Primary Prevention Of Stroke In Children With Sickle Cell Anemia In Nigeria: Protocol For A Mixed Methods Implementation Study In A Community Hospital, Halima Bello-Manga, Lawal Haliru, Kudrat Abdulkareem Ahmed, Abdulkadir Musa Tabari, Bilkisu Usman Farouk, Gloria Yimi Bahago, Aisha Shuaibu Kazaure, Abdulrasheed Sani Muhammad, Samira Abubakar Gwarzo, Ana A Baumann, Michael R Debaun, Allison A King

2020-Current year OA Pubs

BACKGROUND: In Nigeria, approximately 150,000 children with sickle cell anemia (SCA) are born annually, accounting for more than half of all SCA births worldwide. Without intervention, about 11% of children with SCA will develop a stroke before their 20th birthday. Evidence-based practices for primary stroke prevention include screening for abnormal transcranial Doppler (TCD) measurements coupled with regular blood transfusion therapy for at least one year, followed by hydroxyurea (HU) therapy indefinitely. In high-resource countries, this strategy contributes to a 92% decrease in stroke incidence rates. In 2016, as part of a capacity building objective of the Stroke Prevention Trial in …