Digital Commons Network^™

Fatty Acid Translocase: A Culprit Of Lipid Metabolism Dysfunction In Disease, Joseph E Rupert, Mikhail G Kolonin

Faculty, Staff and Student Publications

Dysregulation of lipid deposition into and mobilization from white adipose tissue (WAT) underlies various diseases. Long-chain fatty acids (LCFA) and cholesterol trafficking in and out of adipocytes is a process relying on transporters shuttling lipids from the plasma membrane (PM) to lipid droplets (LD). CD36 is the fatty acid translocase (FAT) that transports LCFA and cholesterol across the PM. Interactions of CD36 with proteins PHB1, ANX2, and CAV1 mediate intercellular lipid transport between adipocytes, hematopoietic, epithelial, and endothelial cells. Intracellularly, the FAT complex has been found to regulate LCFA trafficking between the PM and LD. This process is regulated by …

The Relationship Between The Field-Shifting Phenomenon And Representational Coherence Of Place Cells In Ca1 And Ca3 In A Cue-Altered Environment, Jeremy Miciak, Yusra Ahmed, Phil Capin, David J Francis

Faculty, Staff and Student Publications

Few studies have systematically investigated the reading skill profiles of English Learners (ELs) in late elementary school, a critical developmental period for language and literacy and the most common grades for initial identification with specific learning disabilities (O’Connor et al., 2013). We investigated the reading skill profiles of 331 ELs in 3rd and 4th grades, including ELs with and without risk for dyslexia due to significant deficits in word and pseudo-word reading accuracy and fluency. We utilized latent profile analysis and factor mixture modeling to investigate: (1) the nature and distribution of reading skill profiles; (2) whether these …

Guidelines On Models Of Diabetic Heart Disease, Lisa C Heather, Anne D Hafstad, Ganesh V Halade, Romain Harmancey, Kimberley M Mellor, Paras K Mishra, Erin E Mulvihill, Miranda Nabben, Michinari Nakamura, Oliver J Rider, Matthieu Ruiz, Adam R Wende, John R Ussher

Faculty, Staff and Student Publications

Diabetes is a major risk factor for cardiovascular diseases, including diabetic cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular disease represents the number one cause of death in people with diabetes, there has been a major emphasis on understanding the mechanisms by which diabetes promotes cardiovascular disease, and how antidiabetic therapies impact diabetic heart disease. With a wide array of models to study diabetes (both type 1 and type 2), the field has made major progress in answering these questions. However, each model has its own inherent limitations. Therefore, the purpose of this guidelines document is to provide the …

Neighborhood Socioeconomic Disadvantage And The Neurobiology Of Uncertainty In Traumatically Injured Adults, Carissa W. Tomas, E. Kate Webb, Kenneth P. Bennett, Ashley A. Huggins, Jacklynn M. Fitzgerald, Tara A. Miskovich, Jessica L. Krukowski, Terri A. Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background

Individuals residing in more socioeconomically disadvantaged neighborhoods experience greater uncertainty through insecurity of basic needs such as food, employment, and housing, compared with more advantaged neighborhoods. Although the neurobiology of uncertainty has been less frequently examined in relation to neighborhood disadvantage, there is evidence that neighborhood disadvantage is associated with widespread neural alterations.

Methods

Recently traumatically injured participants (n = 90) completed a picture anticipation task in the magnetic resonance imaging scanner, in which they viewed images presented in a temporally predictable or unpredictable manner. We investigated how neighborhood disadvantage (via area deprivation index [ADI]) was related to …

How Does Parents' Social Support Impact Children's Health Practice? Examining A Mediating Role Of Health Knowledge, Paulin Tay Straughan, Chengwei Xu

Research Collection School of Social Sciences

Background: Many existing studies have found that social support and health knowledge positively affect an individual's health status. However, it is still unclear how parents’ social support and health knowledge influence their children’s obesity. The present study hypothesizes that parents’ health knowledge has a mediating effect on the relationship between social support and children’s health practice regarding weight management. Methods: To test the hypothesis, we conducted a questionnaire survey in Singapore and collected a nationally representative sample of 1488 household responses. Structural equation modeling (SEM) via Stata was used to examine the indirect effects of parents’ social support on children’s …

Scientist's Warning On Climate Change And Insects, Jeffrey A. Harvey, Kévin Tougeron, Rieta Gols, Robin Heinen, Mariana Abarca, Et Al

Biological Sciences: Faculty Publications

Climate warming is considered to be among the most serious of anthropogenic stresses to the environment, because it not only has direct effects on biodiversity, but it also exacerbates the harmful effects of other human-mediate threats. The associated consequences are potentially severe, particularly in terms of threats to species preservation, as well as in the preservation of an array of ecosystem services provided by biodiversity. Among the most affected groups of animals are insects—central components of many ecosystems—for which climate change has pervasive effects from individuals to communities. In this contribution to the scientists’ warning series, we summarize the effect …

Sources Of 7-Ketocholesterol, Metabolism And Inactivation Strategies: Food And Biomedical Applications, Imen Ghzaiel, Khouloud Sassi, Amira Zarrouk, Shubhrima Ghosh, Irundika H.K. Dias, Thomas Nury, Mohamed Ksila, Soukaina Essadek, Mounia Tahri Joutey, Fatiha Brahmi, Wafa Mihoubi, Sandrine Rup-Jacques, Mohammad Samadi, Leila Rezig, Smail Meziane, Taoufik Ghrairi, Olfa Masmoudi-Kouki, Sonia Hammami, Boubker Nasser, Mohamed Hammami, Yuqin Wang, William J. Griffiths, Anne Vejux, Gérard Lizard

Research Outputs: 2025-Present

7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned with civilization diseases (type 2 diabetes, bowel diseases, and metabolic syndrome). The involvement of increased 7-ketocholesterol levels in the pathophysiology of these diseases is widely suspected. Indeed, 7-ketocholesterol at elevated concentrations is a powerful inducer of oxidative stress, inflammation, and cellular degeneration which are common features of all these diseases. It is important to better know the origin of …

Modelo De Predicción De La Demencia En Adultos Mayores De 60 Años [Dementia Prediction Model In Adults Over 60 Years Old], Maria Del Pilar Santacruz-Ortega, Maria Fernanda Cobo-Charry, Bertha Lucia Avendaño-Prieto, Silvia Mejia-Arango

School of Medicine Publications

In order to determine the contribution of the sociodemographic, psychosocial and health variables to a prediction model of dementia in the elderly population, a secondary analysis was carried out with the data from the “Health, Well-being and Aging. Bogotá, 2012”, with 2000 men and women over 60 years of age from urban and rural areas of Bogotá. To select the sample, a probabilistic, multistage, conglomerate and stratified sampling was carried out, based on the 2005 National Census. The SABE questionnaire adapted for Colombia was used. According to the level of measurement of each variable and the distribution of the data, …

The Role Of L-Alanine Signaling In Aspergillus Fumigatus Biofilm Adherence, Carbon Catabolism, And Echinocandin Susceptibility., Joshua D. Kerkaert

Dartmouth College Ph.D Dissertations

Aspergillus fumigatus is a saprophytic filamentous fungus that participates in environmental carbon and nitrogen cycles through the degradation of complex organic substrates. In addition to its ecological role, A. fumigatus is the primary causative agent of a spectrum of diseases depending on the immune status of the individual, the most lethal of which is invasive aspergillosis (IA). Treatment strategies for IA are limited and far too frequently fail. Despite the high rates of treatment failure, antifungal resistance remains relatively low, albeit rising at a concerning rate. Insights into this discrepancy between the rate of treatment failure and the rate of …

Microhabitat And Patch Selection Detection From Gps Tracking Collars Of Semi-Free Ranging Mashona Cattle Within A Semi-Arid Environment, C. Gwatirisa, B. T. Mudereri, T. Chitata, C. Mukanga, M. M. Ngwenya, J. V. Muzvondiwa, R. Mugandani, M. Sungirai

All Peer-Reviewed Publications

Over the last 30 years, the global positioning system (GPS) tracking collars have significantly enhanced livestock grazing behavior studies. Practices designed to understand and improve livestock grazing distribution can now be accurately and cost-effectively monitored with GPS tracking. The behavior and spatiotemporal microhabitat selection of Mashona cattle relative to the season in a semi-free-range grazing system was evaluated using a low‐cost GPS herd activity monitoring (GPSHAM) collar. The GPSHAM automatically logged the position of the lead cow at 20-second intervals over a 7–hour daily grazing period. Additionally, the GPS data was complemented by visually observing the lead cow during daylight …

Influence Of Guideline Operationalization On Youth Activity Prevalence In The International Children’S Accelerometry Database, Catherine Gammon, Andrew J. Atkin, Kirsten Corder, Ulf Ekelund, Bjorge Herman Hansen, Lauren B. Sherar, Lars Bo Anderson, Sigmund Anderssen, Rachel Davey, Pedro C. Hallal, Russell Jago, Susi Kriemler, Peter Lund Kristensen, Soyang Kwon, Kate Nothstone, Russell R. Pate Ph.D., J. O. Salmon, Luis B. Sardinha, Esther M.F. Sluijs

Faculty Publications

Introduction

The United Kingdom and World Health Organization recently changed their youth physical activity (PA) guidelines from 60 min of moderate- to vigorous-intensity PA (MVPA) every day, to an average of 60 min of MVPA per day, over a week. The changes are based on expert opinion due to insufficient evidence comparing health outcomes associated with different guideline definitions. This study used the International Children’s Accelerometry Database to compare approaches to calculating youth PA compliance and associations with health indicators.

Methods

Cross-sectional accelerometer data (n = 21,612, 5–18 yr) were used to examine compliance with four guideline definitions: daily …

The Impacts Of Climate Change On Blackeye Goby, Rhinogobiops Nicholsii, Stress Responses, Reproduction, And Offspring Fitness, Alora Yarbrough

Capstone Projects and Master's Theses

Along with warming and sea level rise, the increasing intensity of ocean acidification (OA) and hypoxia events in coastal environments is of large concern as climate change progresses. Weakened immune function, altered reproductive output, reduced aerobic scope, and hyperventilation are just some of the ways OA and hypoxia negatively affect fish. Under stress, such as OA or hypoxia, fish will produce the hormone cortisol to maintain homeostasis, so cortisol concentration can be used to determine the relative stress an animal is experiencing. This study evaluated the stress response of adult female blackeye gobies under both acute and chronic exposure to …

Comparing Oral Health Behaviours Of Men And Women In The United States, Sharon Su, Martin S. Lipsky, Frank W. Licari, Man Hung

Institute on Aging Publications

Objective

This study used a national database to update and examine current differences in men's and women's oral health and oral health behaviours in the United States.

Methods

Data from the National Health and Nutrition Examination Survey for the 2017–2018 cycle were used to explore the relationship between males and females and their oral health. Multivariate analyses assessed for gender differences in oral health behaviors between genders after controlling for sample demographic characteristics.

Results

The final sample consisted of 4,741 participants. Males tended to have fewer dental visits, worse perception of their gum and tooth health, poorer flossing habits, and …

A Parallel Infodemic: Multifaceted Approaches To Online Public Health Mis- And Disinformation During The Covid-19 Pandemic, Erin Hutchins

UC Law Journal

During the COVID-19 pandemic, communities congregated in online spaces more than ever before. While some people found solidarity online, many others found snippets of false information regarding COVID-19’s origin, transmission, and preventative measures. Inaccurate public health information originated long before the COVID-19 pandemic, but it thrived as the uncertainty around daily living dragged on. The pandemic prompted a conversation about who, if anyone, is responsible for deciphering and regulating the spread of false and misleading information. This Note presents two methods in which inaccurate information can be redressed. First, Section 230 of the Communications Decency Act—which provides sweeping immunity for …

Examining The Social Validity Of Parent Training: Post-Participation Parent Perceptions And Reflections Of Group Triple P, Nycole C. Kauk

USF Tampa Graduate Theses and Dissertations

Child behavior problems are highly prevalent and impactful on the child and their family system, bringing both short-term and long-term consequences (Sanders, 2012). Many risk factors for child behavior problems are modifiable via the use of Behavioral Family Interventions, such as behavioral parent training programs (Kazdin, 1991). Behavioral Family Interventions (BFI) modify factors within the family system to minimize modifiable risk factors and engineer protective factors to produce behavior change (Kazdin, 1991). While several manualized behavioral parenting interventions exist, the Triple P parenting program is one of the most researched and effective programs used internationally, particularly the Level 4 package; …

Technology Roadmap For Standards Of Healthcare Data Cyber Security: Influence Of Public Policy On Consumer Healthcare Cyber Security Protections, Alison Nalven, Courtney Wright, Jennifer Lynn Zeitouni, Nolan Thompson, Sara Ferdousi, Saumya Saxena

Engineering and Technology Management Student Projects

From the dot com boom to now the Internet of Things (IoT) and Machine Learning era, the evolving digital world that people live in has brought new challenges for protecting personal data and information. IoT devices, smart phones, numerous apps, and more, constantly collect personal health data with many positive intentions. However, the recent overturning of Roe vs. Wade by the United States Supreme Court has generated concerns in particular on who and how personal health data can be used by both governments and private companies with unintended consequences for users. Cyber security and regulations for protecting personal health data …

Building The Adolescent Indicators And Gender Gaps Dashboard, Lauren Woyczynski, Christina Misunas, Md. Irfan Hossain

Adolescents and Young People

The Adolescent Atlas for Action (A3) is a suite of tools that summarizes the lives and needs of adolescents around the world to promote evidence-based decision-making. Through accessible and easy-to-grasp data just one click away, the A3 bridges the gap between decisionmakers and evidence to inform policies and programs. The Adolescent Indicators dashboard and Gender Gaps dashboard are two simple but dynamic dashboards that provide insights on the lives of adolescent girls and boys living in low- and middle income countries (LMICs) across 9 thematic domains of wellbeing. The Adolescent Indicators dashboard showcases how adolescent girls or boys are faring …

Élaboration Du Tableau De Bord A3 Des Indicateurs Relatifs Aux Adolescents Et Du Tableau De Bord Des Écarts Entre Les Sexes, Lauren Woyczynski, Christina Misunas, Md. Irfan Hossain

Adolescents and Young People

L'Atlas des Adolescents pour l'Action (A3) est une suite d'outils qui résume la vie et les besoins des adolescents du monde entier afin de promouvoir une prise de décision fondée sur des données probantes. Grâce à ses données accessibles et faciles à saisir en un seul clic, l'A3 comble le fossé entre les décideurs et les données factuelles afin d'éclairer les politiques et les programmes. Le tableau de bord des indicateurs relatifs aux adolescents et le tableau de bord des écarts entre les sexes sont deux tableaux de bord simples mais dynamiques qui donnent un aperçu de la vie des …

L’Élaboration De La Liste De Contrôle Pour Les Politiques A3, Yeeva Cheng, Cara Kraus-Perrotta

Adolescents and Young People

L'Atlas des Adolescents pour l'Action (A3) est une suite d'outils qui résume la vie et les besoins des adolescents du monde entier afin de promouvoir une prise de décision fondée sur des données probantes. Grâce à des données accessibles et faciles à saisir en un seul clic, l'A3 comble le fossé entre les décideurs et les données factuelles afin d'éclairer les politiques et les programmes. La liste de contrôle des politiques A3, créée par le GIRL Center du Population Council, présente une liste de politiques nationales pertinentes pour la vie des adolescents dans 9 domaines thématiques, et indique si les …

Building The A3 Policy Checklist, Yeeva Cheng, Cara Kraus-Perrotta

Adolescents and Young People

The Adolescent Atlas for Action (A3) is a suite of tools that summarizes the lives and needs of adolescents around the world to promote evidence-based decision-making. Through accessible and easy-to-grasp data just one click away, the A3 bridges the gap between decisionmakers and evidence to inform policies and programs. The A3 Policy Checklist, created by the Population Council’s GIRL Center, features a curated list of national policies relevant to the lives of adolescents under 9 thematic domains, and whether countries have enacted each policy. The checklist presents a snapshot of commitments made to achieving adolescent wellbeing through adolescent-focused policies. As …

Differences Between African American And White Males In Grades 6-8: Comparative Evidence From Selected Texas Rural Schools, Sheenah Maria Hopkins-Johnson

Electronic Theses and Dissertations

The academic achievement gap among Black males in grades 6-8 across Texas is a growing concern. Based on the State of Texas Assessments of Academic Readiness (STAAR), secondary data from the Texas Education Agency (TEA) was used to evaluate scores from a sample of Texas rural schools. In this quantitative, non-experimental methods study, the dependent variable examined was the STAAR reading score at the “meets grade level,” and the independent dichotomous variables examined were: race, whether or not the student was classified in one of the following groups: ECD, at-risk, and special education. Academic trends from the 2017-2019 academic school …

Core-Designated Courses, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Course Descriptions, Saint Mary's College Of California

Academic Catalog

No abstract provided.

Postprandial Symptoms In Patients With Symptoms Of Gastroparesis: Roles Of Gastric Emptying And Accommodation, Henry P Parkman, Mark L Van Natta, Alan H Maurer, Kenneth L Koch, Madhusudan Grover, Zubair Malik, Irene Sarosiek, Thomas L Abell, Robert Bulat, Braden Kuo, Robert J Shulman, Gianrico Farrugia, Laura Miriel, James Tonascia, Frank Hamilton, Pankaj J Pasricha, Richard W Mccallum

Faculty, Staff and Students Publications

Patients often are evaluated for gastroparesis because of symptoms occurring with meals. Gastric emptying scintigraphy (GES) is used for gastroparesis diagnosis, although results are not well correlated with gastroparesis symptoms. The aim of this study is to assess relationships between gastroparesis symptoms, gastric emptying (GE), and gastric accommodation (GA). Patients with symptoms of gastroparesis completed the Patient Assessment of Upper GI Symptoms (PAGI-SYM) and recorded symptoms during GES and water load satiety test (WLST), an indirect assessment for GA. A total of 109 patients with gastroparesis symptoms were assessed. Symptom severity increased after GES meal for stomach fullness, belching, nausea, …

Implementing A Screening Tool For Social Determinants Of Health In A Rural Primary Care Clinic, Kimberly S. Roberts

Electronic Theses and Dissertations

Abstract The environment and conditions in which people are born, live, learn, work, play, worship, and age are social determinants of health (SDOH). Specifically, SDOH are categorized into five domains: (a) economic stability, (b) education access and quality, (c) health care access and quality, (d) neighborhood and built environment, and (e) social and context communities. Inequities in these domains are associated with health disparities that lead to poorer health and quality of life. The aim of this quality improvement project was to implement the Protocol for Responding to and Assessing Patient Assets, Risks, and Experiences (PRAPARE) to screen patients’ SDOH …

Leading For Sustainability In School-Community Partnerships, Kimberly Renee Benavides

Electronic Theses and Dissertations

Schools receive support in the form of partnerships with organizations such as businesses, churches, and non-profits for many reasons, and such partnerships are beneficial to students and the school community. The purpose of this participatory qualitative study was to determine behaviors of elementary school principals that result in the sustainability of school-community partnerships beyond the initial year of implementation. Elementary school principals in an urban public school district in North Texas were interviewed along with leaders from their corresponding community partners to determine the role of the principal in school-community partnership work. Through an in-depth analysis of interview transcripts, the …

Insurance Coverage And Respiratory Morbidities In Bronchopulmonary Dysplasia., Joseph M. Collaco, Michael C. Tracy, Catherine A. Sheils, Jessica L. Rice, Lawrence M. Rhein, Leif D. Nelin, Paul E. Moore, Winston M. Manimtim, Jonathan C. Levin, Khanh Lai, Lystra P. Hayden, Julie L. Fierro, Eric D. Austin, Stamatia Alexiou, Amit Agarwal, Natalie Villafranco, Roopa Siddaiah, Antonia P. Popova, Ioana A. Cristea, Christopher D. Baker, Manvi Bansal, Sharon A. Mcgrath-Morrow

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Preterm infants and young children with bronchopulmonary dysplasia (BPD) are at increased risk for acute care utilization and chronic respiratory symptoms during early life. Identifying risk factors for respiratory morbidities in the outpatient setting could decrease the burden of care. We hypothesized that public insurance coverage was associated with higher acute care usage and respiratory symptoms in preterm infants and children with BPD after initial neonatal intensive care unit (NICU) discharge.

METHODS: Subjects were recruited from BPD clinics at 10 tertiary care centers in the United States between 2018 and 2021. Demographics and clinical characteristics were obtained through chart …

The 5th Edition Of The World Health Organization Classification Of Haematolymphoid Tumours: Myeloid And Histiocytic/Dendritic Neoplasms, Joseph D Khoury, Eric Solary, Oussama Abla, Yassmine Akkari, Rita Alaggio, Jane F Apperley, Rafael Bejar, Emilio Berti, Lambert Busque, John K C Chan, Weina Chen, Xueyan Chen, Wee-Joo Chng, John K Choi, Isabel Colmenero, Sarah E Coupland, Nicholas C P Cross, Daphne De Jong, M Tarek Elghetany, Emiko Takahashi, Jean-Francois Emile, Judith Ferry, Linda Fogelstrand, Michaela Fontenay, Ulrich Germing, Sumeet Gujral, Torsten Haferlach, Claire Harrison, Jennelle C Hodge, Shimin Hu, Joop H Jansen, Rashmi Kanagal-Shamanna, Hagop M Kantarjian, Christian P Kratz, Xiao-Qiu Li, Megan S Lim, Keith Loeb, Sanam Loghavi, Andrea Marcogliese, Soheil Meshinchi, Phillip Michaels, Kikkeri N Naresh, Yasodha Natkunam, Reza Nejati, German Ott, Eric Padron, Keyur P Patel, Nikhil Patkar, Jennifer Picarsic, Uwe Platzbecker, Irene Roberts, Anna Schuh, William Sewell, Reiner Siebert, Prashant Tembhare, Jeffrey Tyner, Srdan Verstovsek, Wei Wang, Brent Wood, Wenbin Xiao, Cecilia Yeung, Andreas Hochhaus

Faculty, Staff and Students Publications

The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought …

Changes In Measures Of Vestibular And Balance Function And Hippocampus Volume In Alzheimer's Disease And Mild Cognitive Impairment, Helen S Cohen, Christie M Lincoln, Valory N Pavlik, Haleh Sangi-Haghpeykar

Faculty, Staff and Students Publications

OBJECTIVE: To test the hypotheses that people with Alzheimer's disease and mild cognitive impairment have increased frequency of vestibular impairments and decreased hippocampal volume compared with healthy age-matched controls.

STUDY DESIGN: Retrospective, with some historical controls.

SETTING: Out-patient, tertiary care center.

SUBJECTS: People with mild to moderate dementia diagnosed with Alzheimer's disease and with mild cognitive impairment. Main Outcome Measures: A standard clinical battery of objective tests of the vestibular system, and screening for balance; available clinical diagnostic magnetic resonance imaging (MRIs) were reviewed and postprocessed to quantify the left and right hippocampal volumes utilizing both manual segmentation and computer …

Coaching For Childbearing Health: A Theory Synthesis, Jennifer M. Ohlendorf, Lisa Anders

College of Nursing Faculty Research and Publications

This article describes development of a theory to guide nurses promoting perinatal weight self-management behaviors. The Coaching for Childbearing Health (CoaCH) Model was developed through synthesis of the Individual and Family Self-Management Theory with Transitions Theory, following Walker and Avant's process of theory synthesis. Qualitative data were integrated to provide perinatal context. The CoaCH Model is composed of context factors that shape a nurse coaching intervention, supporting patients' self-management efforts. Sustained engagement in weight self-management behaviors will impact the long-term health of both the birthing person and the child. This model is a testable framework for future perinatal health promotion …