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Children With Functional Abdominal Pain Disorders Successfully Decrease Fodmap Food Intake On A Low Fodmap Diet With Modest Improvements In Nutritional Intake And Diet Quality, Vishnu Narayana, Ann R Mcmeans, Rona L Levy, Robert J Shulman, Bruno P Chumpitazi

Faculty, Staff and Students Publications

BACKGROUND: We sought to determine how a low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet (LFD) affected high FODMAP food intake, nutrient intake, and diet quality in children with functional abdominal pain disorders (FAPD).

METHODS: Children (ages 7-13 years) with Rome IV FAPD began a dietitian-guided LFD. Three-day food records were captured at baseline and 2-3 weeks into the LFD. Intake of high FODMAP foods, energy, macronutrients, micronutrients, food groups, and ultra-processed foods were determined.

KEY RESULTS: Median age of participants was 11 years, and 19/31 (61%) were female. Twenty-eight (90%) decreased high FODMAP food intake on the LFD: …

Heart Failure-Type Symptom Scores In Chronic Kidney Disease: The Importance Of Body Mass Index, Carl P Walther, Julia S Benoit, L Parker Gregg, Nisha Bansal, Vijay Nambi, Harold I Feldman, Michael G Shlipak, Sankar D Navaneethan

Faculty, Staff and Students Publications

Objectives: This analysis sought to determine factors (including adiposity-related factors) most associated with HF-type symptoms (fatigue, shortness of breath, and edema) in adults with chronic kidney disease (CKD).

Background: Symptom burden impairs quality of life in CKD, especially symptoms that overlap with HF. These symptoms are common regardless of clinical HF diagnosis, and may be affected by subtle cardiac dysfunction, kidney dysfunction, and other factors. We used machine learning to investigate cross-sectional relationships of clinical variables with symptom scores in a CKD cohort.

Methods: Participants in the Chronic Renal Insufficiency Cohort (CRIC) with a baseline modified Kansas City Cardiomyopathy Questionnaire …

Dietary Inorganic Nitrate As An Ergogenic Aid: An Expert Consensus Derived Via The Modified Delphi Technique, Oliver M. Shannon, Jason D. Allen, Raul Bescos, Louise Burke, Tom Clifford, Chris Easton, Javier T. Gonzalez, Andrew M. Jones, Kristin L. Jonvik, Filip J. Larsen, Peter Peeling, Barbora Piknova, Mario Siervo, Anni Vanhatalo, Kerry Mcgawley, Simone Porcelli

School of Health Professions

Abstract Introduction Dietary inorganic nitrate is a popular nutritional supplement, which increases nitric oxide bioavailability and may improve exercise performance. Despite over a decade of research into the effects of dietary nitrate supplementation during exercise there is currently no expert consensus on how, when and for whom this compound could be recommended as an ergogenic aid. Moreover, there is no consensus on the safe administration of dietary nitrate as an ergogenic aid. This study aimed to address these research gaps. Methods The modified Delphi technique was used to establish the views of 12 expert panel members on the use of …

Improving Hypertension Self Management In African American Men, Elizabeth C. Felix

Electronic Theses and Dissertations

Hypertension is a cardiopulmonary condition linked to genetic, environmental, and social factors. Left untreated, it can lead to fatal conditions such as heart disease. In the United States, African Americans experience disproportionately high rates of hypertension, earlier onset of symptoms, greater severity, and higher related mortality rates. African Americans also statistically have more difficulty self-managing their hypertension than other demographics. The aim of this project was (a) to identify, define, and measure perceived barriers to self-management of hypertension among African American men and (b) to target these barriers and increase patient engagement through personalized intervention plans. The researcher recruited 24 …

Development Of An Integrated Salt Cartridge-Reverse Electrodialysis (Red) Device To Increase Electrolyte Concentrations To Biomedical Devices, Efecan Pakkaner, Jessica L. Orton, Caroline G. Campbell, Jamie A. Hestekin, Christa N. Hestekin

Chemical Engineering Faculty Publications and Presentations

Emerging technologies in nanotechnology and biomedical engineering have led to an increase in the use of implantable biomedical devices. These devices are currently battery powered which often means they must be surgically replaced during a patient’s lifetime. Therefore, there is an important need for a power source that could provide continuous, stable power over a prolonged time. Reverse electrodialysis (RED) based biopower cells have been previously used to generate continuous power from physiologically relevant fluids; however, the low salinity gradient that exists within the body limited the performance of the biopower cell. In this study, a miniaturized RED biopower cell …

Two Cases Of Autoimmune Syndrome Induced By Adjuvants (Asia): A Multifaceted Condition Calling For A Multidisciplinary Approach, Christine Loftis, Aidee C. Nunez, Mauricio De La Garza, Emilia Dulgheru

School of Medicine Publications

Silicone implants have been used for cosmetic enhancement and reconstructive purposes for over 60 years. Despite assiduous efforts to ensure safety, there is continuous evidence that they are not as biologically inert as previously postulated. We present two cases of autoimmune syndrome induced by adjuvants (ASIA) in Hispanic women. The first patient developed biopsy-proven immune-mediated necrotizing myopathy that was successfully treated with the combination of silicone explantation along with immunosuppressive therapy. Findings after implant removal demonstrated rupture and leakage of silicone from gluteal implants. The second patient developed autoimmune hemolytic anemia in the setting of a ruptured silicone breast implant. …

First Steps: Primary Outcomes Of A Randomized, Stepped-Care Behavioral Clinical Trial For Parents Of Young Children With New-Onset Type 1 Diabetes, Marisa E Hilliard, Carrie Tully, Maureen Monaghan, Tom Hildebrandt, Christine H Wang, John R Barber, Lauren Clary, Katherine Gallagher, Wendy Levy, Fran Cogen, Celia Henderson, Lefkothea Karaviti, Randi Streisand

Faculty, Staff and Students Publications

OBJECTIVE: Despite the emotional challenges of parental adjustment to a child's type 1 diabetes diagnosis and the unique complexities of early childhood, there are few programs designed to meet the needs of parents of young children at new onset. This study evaluated First STEPS (Study of Type 1 in Early childhood and Parenting Support), a stepped-care behavioral intervention designed to support parents' psychosocial functioning and promote children's glycemic outcomes.

RESEARCH DESIGN AND METHODS: Using a two-site randomized clinical trial design, parents (n = 157) of children aged 1-6 years completed baseline data within 2 months of diabetes diagnosis and were …

Newborn Mid-Upper Arm Circumference Identifies Low-Birth Weight And Vulnerable Infants: A Secondary Analysis, D Taylor Hendrixson, Patrick N Lasowski, Aminata Shamit Koroma, Mark J Manary

2020-Current year OA Pubs

BACKGROUND: Low birth weight (LBW) infants are at increased risk of morbidity and mortality. Identification of LBW may not occur in settings where access to reliable scales is limited. Mid-upper arm circumference (MUAC) may be an accessible, low-cost measure to identify LBW and vulnerable infants.

OBJECTIVES: We explored the validity of newborn MUAC in identifying LBW and vulnerable newborns in rural Sierra Leone.

METHODS: This study was a secondary analysis of infant data from a randomized controlled clinical trial of supplementary food and anti-infective therapies compared with standard care for undernourished pregnant women. Data for singleton liveborn infants with birth …

Translation And Cross-Cultural Validation Of A Precision Health Tool, The Suboptimal Health Status Questionnaire-25, In Korean, Zheng Guo, Ruoyu Meng, Yulu Zheng, Xingang Li, Ziqi Zhou, Leilei Yu, Qian Tang, Ying Zhao, Monique Garcia, Yuxiang Yan, Song Manshu, Lois A. Balmer, Jun Wen, Haifeng Hou, Xuerui Tan, Wei Wang, Suboptimal Health Study Consortium (Shsc), Global Health Epidemiology Research Group (Gherg)

Research outputs 2022 to 2026

Background

Suboptimal health status (SHS) is a reversible stage between health and illness that is characterized by health complaints, low energy, general weakness, and chronic fatigue. The Suboptimal Health Status Questionnaire-25 (SHSQ-25) has been validated in three major populations (African, Asian, and Caucasian) and is internationally recognized as a reliable and robust tool for health estimation in general populations. This study focused on the development of K-SHSQ-25, a Korean version of the SHSQ-25, from its English version.

Methods

The SHSQ-25 was translated from English to Korean according to international guidelines set forth by the World Health Organization (WHO) for health …

Developing Culturally Appropriate Food Literacy Resources For Aboriginal Children With Foodbank Wa’S Superhero Foods®, Jennifer Tartaglia, Roslyn Giglia, Jill Darby

Research outputs 2022 to 2026

Issue addressed

In Australia, food sovereignty of traditional landowners has been marginalised by the globalisation of food systems and resulted in limited opportunities for children to experience familiar bush tucker foods as healthy choices, particularly in a school environment. Superhero Foods^® themed teaching resources focus on the development of nutrition education materials that included traditional Aboriginal foods together with contemporary foods readily available in regional/remote communities.

Methods

Consultation with an Aboriginal expert and Aboriginal artist; local, regional/remote teachers and stakeholders informed the development of tailored resources including food cartoon characters, school lesson plans and a storybook. The latter was …

The Reported External Traumas Among People With Diabetes-Related Foot Ulcers And Their Outcomes: A Systematic Review Of Case Reports, Ma'en Zaid Abu-Qamar, Vivien Kemp, Lisa Whitehead

Research outputs 2022 to 2026

The objective of this systematic review was to collate evidence published in case reports on the reported origins of external traumas that contribute to the development of diabetic foot ulcers and their outcomes. The review also aimed to suggest reporting criteria for external traumas contributing to the development of diabetic foot ulcers. The search strategy led to the identification of 1224 articles across six electronic databases. Additional articles were also sourced from other electronic platforms (Google scholar) and the reference lists of the included case reports. Ninety-four articles met the inclusion criteria and were published between 1989 and 2020. The …

Application Of A Sustainability Framework To Enhance Australian Food Literacy Programs In Remote Western Australian Communities, Leisha M. Aberle, Julia R. Platts, Marie A. Kioutis, Louise M. Haustead, Stephanie L. Godrich

Research outputs 2022 to 2026

Issue addressed: Food literacy programs aim to build individuals’ knowledge, skills and self-efficacy to adopt healthy food choices conducive to reducing the risk of chronic diseases, such as obesity. Foodbank WA’s (FBWA) Healthy Food for All ® nutrition programs have supported the improvement of food literacy knowledge and skills among vulnerable people living in the Pilbara. Methods: A Sustainability Framework containing ten sustainability factors was overlaid with social ecological model (SEM) levels of influence to form a matrix. The use of this matrix facilitated sustainability strategy appraisal within three food literacy programs delivered in remote WA. Results: Programs included multiple …

Countermovement Jump And Squat Jump Force-Time Curve Analysis In Control And Fatigue Conditions, Steven Hughes, John Warmenhoven, G. Gregory Haff, Dale W. Chapman, Sophia Nimphius

Research outputs 2014 to 2021

This study aimed to reanalyze previously published discrete force data from countermovement jumps (CMJs) and squat jumps (SJs) using statistical parametric mapping (SPM), a statistical method that enables analysis of data in its native, complete state. Statistical parametric mapping analysis of 1-dimensional (1D) force-time curves was compared with previous zero-dimensional (0D) analysis of peak force to assess sensitivity of 1D analysis. Thirty-two subjects completed CMJs and SJs at baseline, 15 minutes, 1, 24, and 48 hours following fatigue and control conditions in a pseudo random cross-over design. Absolute (CMJ_ABS/SJ_ABS) and time-normalized (CMJ_NORM/SJ_NORM) …

Radiotherapy For Elderly Patients With Glioblastoma: An Assessment Of Hypofractionation And Modern Treatment Techniques, Jennifer K. Matsui, Jiayi Huang, Et Al.

2020-Current year OA Pubs

Glioblastoma (GBM) is a disease with a poor prognosis. For decades, radiotherapy has played a critical role in the management of GBM. The standard of care radiation prescription is 60 Gy in 30 fractions, but landmark trials have historically excluded patients older than 70 years. Currently, there is considerable variation in the management of elderly patients with GBM. Shortened radiation treatment (hypofractionated) regimens have been explored since conventional treatment schedules are lengthy and many elderly patients have functional, cognitive, and social limitations. Clinical trials have demonstrated the effectiveness of hypofractionated radiotherapy (40 Gy in 15 fractions) to treat elderly or …

Redbird Scholar, Vol. 8, No. 1 (Fall 2022), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

Wellness In The Face Of Frailty Among Older Adults In First Nations Communities, Morgan Slater, Gabrielle Bruser, Roseanne Sutherland, Melissa K Andrew, Wayne Warry, Kristen M Jacklin, Jennifer D Walker

Faculty, Staff and Student Publications

OBJECTIVES: First Nations people report high levels of wellness despite high rates of chronic illness. Our goal was to understand the factors associated with wellness among First Nations adults in Ontario who were considered frail.

METHODS: Using the First Nations Regional Health Survey, we created a profile of First Nations adults (aged 45+) who were categorized as "frail" (weighted sample size = 8121). We used multivariate logistic regression to determine associations between wellness (as measured by self-reported physical, emotional, mental, and spiritual balance) and determinants of health.

RESULTS: Rates of reported wellness were high among those who were frail, ranging …

The Relationship Between Socioeconomic Factors With Fertility Rate In Malaysia, Ahmad Muadz Zulqarnain, Mazlynda Md Yusuf

Malaysian Journal of Computing (MJoC)

The issue of an ageing population is on the rise globally, and Malaysia is not excluded from facing this issue. Past literature has recognized that the declining fertility rate is one of the main factors that lead to this problem. However, along with the declining fertility rate in Malaysia over time, there are also changes in social and economic factors such as increment in female labor participation, higher house income and consumption expenditure, increasing inflation and changes in the demographic of the population. The study has become a concern since these factors could affect the declining fertility rate. Hence, this …

Prediction Of Life Expectancy For Asian Population Using Machine Learning Algorithms, Nurul Shahira Pisal, Shuzlina Abdul-Rahman, Mastura Hanafiah, Saidatul Izyanie Kamarudin

Malaysian Journal of Computing (MJoC)

Predicting life expectancy has become more important nowadays as life has become more vulnerable due to many factors, including social, economic, environmental, education, lifestyle, and health condition. A lot of studies on life expectancy have been carried out. However, studies focusing on the Asian population are limited. This study presents machine learning algorithms for life expectancy based on the Asian population dataset. Comparisons are made between tree classifier models, namely, J48, Random Tree, and Random Forest. Cross validations with 10 and 20 folds are used. Results show that the highest accuracy is obtained with Random Forest with 84% accuracy with …

The Effects Of Cyp1a2 And Adora2a Genotypes Association With Acute Caffeine Intake On Physiological Effects And Performance: A Systematic Review, Rabia Rümeysa Kocatürk, İlke Karagöz, Ebru Yanik, Öznur Özge Özcan, Türker Tekin Ergüzel, Mesut Karahan, Nevzat Tarhan

Baltic Journal of Health and Physical Activity

Introduction: This systematic review aims to examine the effects of the CYP1A2 −163C>A and ADORA2A 1976T>C polymorphism on physiological effects and performance relative to caffeine consumption. Material and Methods: In this study, electronic databases including PubMed, Web of Science Core Collection, Korean Journal Database, Russian Science Citation Index, SciELO Citation Index, Scopus, ScienceDirect, ProQuest Dissertations & Thesis Global and EBSCO were searched. Results: The results highlight that individuals with the TT or CT/CC genotype can have differences in caffeine consumption, and C carriers may have increases in the maximum oxygen uptake (VO₂max). The AA or AC/CC …

In Search Of A Value Proposition For Covid-19 Testing In The Work Environment: A Social Marketing Analysis, Claudia Parvanta, Alberto J. Caban-Martinez, Naciely Cabral, Cynthia K. Ball, Kevin G. Moore, Adrienne Eastlake, Jeffrey L. Levin, Dalia E. Nessim, Matthew S. Thiese, Paul A. Schulte

School of Medicine Faculty Publications and Presentations

Background: This study examined employer experience with SARS-CoV-2 (COVID-19) asymptomatic testing through a social marketing lens. Social marketing uses commercial marketing principles to achieve socially beneficial ends including improved health and safety behavior. Method: Twenty employers across 11 occupational sectors were interviewed about implementation of COVID-19 testing from January through April 2021. Recorded transcripts were coded and analyzed using marketing's "Four P's": "product," "price," "place," "promotion." Results: COVID-19 tests (product) were uncomfortable, were easily confused, and didn't solve problems articulated by employers. Testing was not widely available or didn't line up with shifts or locations (place). The perceived price, which …

Prevalence Of Geriatric Syndromes In Elderly Undergoing Chemotherapy, Aulia Rizka, Helda Helda, Findy Prasetyawaty, Arcita Hanjani

Jurnal Penyakit Dalam Indonesia

Introduction. Geriatric syndromes is associated with poor survival, poor quality of life and increased chemotoxicity risk in elderly receiving chemotherapy. Geriatric syndromes is currently not routinely evaluated in pre-chemotherapy clinical setting. This study aimed to identify the prevalence of some geriatric syndromes in elderly patients undergoing chemotherapy.Methods. This study is part of primary study investigating geriatric syndromes in elderly with cancer. A descriptive cross sectional study during March 2020 – March 2021 was conducted to elderly patients before chemotherapy administration in Cipto Mangunkusumo Hospital, a national referral hospital in Jakarta. Patients were recruited consecutively. Patients underwent Comprehensive Geriatric Assesment (CGA), …

Perceived Barriers And Needs Of Dietary Macro Nutrient Intake In Adolescent Schoolgirls In Small Island, Healthy Hidayanty, Abdul Razak Thaha, Syamsuar Manyullei, Rahayu Indriasari, Mesra Rahayu, Devintha Virani, Leng Huat Foo

Media Kesehatan Masyarakat Indonesia

Adolescence is an important period of rapid change in biological, psychosocial and cognitive growth and development marked by significant increases in nutrition and energy needs. The study aimed to explore perceived barriers and needs regarding dietary macronutrient intake in adolescent girls in Barrang Lompo Island in Makassar City, South Sulawesi Province, Indonesia. The qualitative design drew on constructs from social cognitive theory. The sample consisted of 18 adolescent girls and their mothers from grades 8 to 11 whose dietary macronutrient intake was less than the recommended dietary allowance. A semi-structured interview protocol was used to explore perceived barriers and needs …

System And Information Qualities In Mobile Fitness Apps And Their Effects On User Behavior And Performance, Mobark Q. Aldossari, Quynh N. Nguyen, Anh Ta, Steven A. Schulz

Management Faculty Publications

Grounded in goal setting theory and other IS models, this study introduces a robust model, that examines the determinants of MFA goal setting and goal tracking use, and their impact on user behavior and achievement. The empirical results show that system quality and information quality are two key determinants of MFA goal setting and goal tracking use, which significantly influence a user’s goal achievement and behavioral change in terms of physical activities.

Impact Of Mineral Fertilization, Home Compost And Farm Manure On Yield Components And Nutritional Parameters Of Tomato Fruit, Karima Ghebbi, Mohamed Meziane Bellal

Journal of Bioresource Management

Mineral fertilization, home compost and farm manure were tested on tomato hybrid variety cultivated in open field (Lycopersicon esculentum Mill.) evaluating the effect on growth, yield components and nutritional parameters of fruit. Tomato variety was grown on clay-loam soil poor in potassium and nitrogen but rich in phosphor and fairly well provided with organic matter. The test was carried out in a randomized complete block design with four replications. Results showed that supply by home compost revealed to be better on most of parameters measured compared with farm manure and mineral fertilization. Fruit yield was positively affected by home …

Effect Of Drying Method On Biochemical Composition And Nutritional Quality Of Sandfish (Scincus Scincus) Consumed In South-East Algeria, Ikram Toumi, Ifriqya Medila, Hamdi Bendif

Journal of Bioresource Management

Sandfish is highly consumed in South-East of Algeria for its gustative and nutritional qualities. The aim of this study was to evaluate the influence of drying methods on fatty acids and amino acids sandfish quality. Biochemical analyzes were performed using the analytical methods adopted by the Association of Official Analytical Chemists (AOAC) method. The fatty acid composition was evaluated using the gas chromatography and the high-performance liquid chromatography (HPLC) method was used for the amino acids analysis. Significant differences were found in the moisture, ash, protein and fat content. Chromatogram analysis revealed the existence of nine (9) fatty acids the …

Triazole Fungicide Prosaro Ec 250 - Induced Hematologicaland Biochemical Alterations In Male Rabbits (Oryctolagus Cuniculus), Debabsa Rafika, Khaldi Fadila, Grara Nedjoud, Bouzahouane Hana, Guezgouz Noureddine, Gheid Abdelhak

Journal of Bioresource Management

The study aimed to evaluate the toxic effects of fungicide Prosaro 250 EC on hematological profiles and renal functional-biochemical markers, as well as blood glucose level .Twenty-four male rabbits were equally and randomly divided into control untreated group (G1) (n =6) received distilled water and standard food, and three treated groups (n=6 each) received by oral gavage Prosaro 250 EC at three doses (mg/kg body weight (bw)), 0.093 (G2), 0.186 (G3) and 0.465 mg/kg bw (G4) for 21 days .Results revealed a significant decrease in the kidney weight, and a significant increase in the levels of serum urea, uric acid, …

Mixed Random And Nonrandom Allocation, And Group Randomization Have Been Mislabeled And Misanalysed, Necessitating Reanalysis Comment On Conner Et Al Kiwic For Vitality: Results Of A Randomized Placebo-Controlled Trial Testing The Effects Of Kiwifruit Or Vitamin C Tablets On Vitality In Adults With Low Vitamin C Levels, Colby J Vorland, Yasaman Jamshidi-Naeini, Lilian Golzarri-Arroyo, Andrew W Brown, David B Allison

Children’s Nutrition Research Center Staff Publications

We read the report by Conner and colleagues that tested whether kiwifruit or vitamin C affected measures of vitality [...].

Sequencing Individual Genomes With Recurrent Genomic Disorder Deletions: An Approach To Characterize Genes For Autosomal Recessive Rare Disease Traits, Bo Yuan, Katharina V Schulze, Nurit Assia Batzir, Jefferson Sinson, Hongzheng Dai, Wenmiao Zhu, Francia Bocanegra, Chin-To Fong, Jimmy Holder, Joanne Nguyen, Christian P Schaaf, Yaping Yang, Weimin Bi, Christine Eng, Chad Shaw, James R Lupski, Pengfei Liu

Children’s Nutrition Research Center Staff Publications

Background: In medical genetics, discovery and characterization of disease trait contributory genes and alleles depends on genetic reasoning, study design, and patient ascertainment; we suggest a segmental haploid genetics approach to enhance gene discovery and molecular diagnostics.

Methods: We constructed a genome-wide map for nonallelic homologous recombination (NAHR)-mediated recurrent genomic deletions and used this map to estimate population frequencies of NAHR deletions based on large-scale population cohorts and region-specific studies. We calculated recessive disease carrier burden using high-quality pathogenic or likely pathogenic variants from ClinVar and gnomAD. We developed a NIRD (NAHR deletion Impact to Recessive Disease) score for recessive …

Health Safety In Drinks: Evaluation Of Certain Food Additives In Algeria, Saoussene Chernine, Samira Djekoun Bensoltane

Journal of Bioresource Management

Consumption of drinks remains a controversial issue for public health. For more than 50 years, potential adverse reactions to additives have been suggested, but data to date are conflicting. The purpose of this article is to provide an approach to the health threat by inventorying the food additives used in 304 local and imported drinks sold in the Algerian market and classifying them according to their toxicity. In second time, survey population destinated to 1200 subjects to evaluate their drink consumption and health problems. The results show that the inventoried drinks contain many food additives, mostly consisting of dyes. Toxic …

Sex-Specific Epigenetic Development In The Mouse Hypothalamic Arcuate Nucleus Pinpoints Human Genomic Regions Associated With Body Mass Index, Harry Mackay, Chathura J Gunasekara, Kit-Yi Yam, Dollada Srisai, Hari Krishna Yalamanchili, Yumei Li, Rui Chen, Cristian Coarfa, Robert A Waterland

Duncan NRI Faculty and Staff Publications

Recent genome-wide association studies corroborate classical research on developmental programming indicating that obesity is primarily a neurodevelopmental disease strongly influenced by nutrition during critical ontogenic windows. Epigenetic mechanisms regulate neurodevelopment; however, little is known about their role in establishing and maintaining the brain's energy balance circuitry. We generated neuron and glia methylomes and transcriptomes from male and female mouse hypothalamic arcuate nucleus, a key site for energy balance regulation, at time points spanning the closure of an established critical window for developmental programming of obesity risk. We find that postnatal epigenetic maturation is markedly cell type and sex specific and …