Digital Commons Network^™

Exploiting Modulation Of The Blood-Brain And Blood-Tumor Barrier Permeability By Translational Focused Ultrasound For Therapeutic Delivery To Cns Metastases, Tasneem A. Arsiwala

Graduate Theses, Dissertations, and Problem Reports (ETD)

Transcranial low-intensity focused ultrasound is a unique technology to modulate the integrity of tight endothelial junctions and transiently increase BBB/BTB permeability to enhance therapeutic delivery. Despite promising early studies, present literature lacks agreement on key experimental conditions, which restricts our knowledge and the technique's widespread translation. This dissertation first provides a critical review of the current gaps in knowledge regarding the universal use of LiFUS in preclinical and clinical use. We then identify key parameters for translational and predictable opening of the BBB using a 3T MRI coupled with a clinical device. Our investigation highlights that passive permeability of the …

The Relationship Between Oral Health And Health-Related Quality Of Life Among Hemodialysis Patients In Rural West Virginia, Kimberly A. Wallace

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Approximately 786,000 Americans are currently diagnosed with end-stage renal disease, 71% of whom are undergoing hemodialysis (HD) treatment. There is a bidirectional relationship between chronic kidney disease and periodontal disease. Among HD patients, poor oral health is prominent and can negatively impact general health and health-related quality of life. Appalachian residents experience extreme health and poverty inequities and limited access to healthcare and dental providers.

Method: The study was designed based on the Andersen Behavioral Model of Health Services Use. 120 participants from 6 outpatient HD centers were enrolled. Data were collected using a 34-item questionnaire including oral health …

An Investigation Into The Mechanism Of Proteasome Dysfunction In Neurodegenerative Disease And The Biological Impact Of Proteasome Hyperactivation In C. Elegans, Raymond T. Anderson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Aging is an inevitable process that occurs as humans grow older. It is characterized by the chronological accumulation of cellular damage over time leading to functional decline as an organism grows older. Several processes are thought to contribute to the aging phenomenon, but one of the most prolific of these is the disruption of protein homeostasis (proteostasis). The collapse of proteostasis can lead to accelerated aging and the development of age-related diseases including devastating neurodegenerative diseases (NDs) like Alzheimer and Parkinson disease. Virtually all NDs are characterized by the buildup of proteins in and around neurons resulting in neuronal death …

Smallmouth Bass (Micropterus Dolomieu) Population Characteristics And An Evaluation Of Management Responses In Two West Virginia Watersheds, Jacob D. Harrell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Smallmouth Bass (Micropterus dolomieu) population characteristics were examined within the Tygart and Cheat River watersheds of north-central West Virginia. Growth, mortality and recruitment were examined for each individual population prior to modeling potential effects of various management schemes. Smallmouth Bass were sampled for total length and weight, aged using sagittal otoliths and sexed through observations of gonadal or ovarian development. Growth for each population was examined using von Bertalanffy growth models and assessed for variation among populations. Population demographic characteristics differed between and among populations, most noticeably between riverine and lacustrine habitat, whereby growth, mortality and recruitment were higher …

Needs Assessment Of Diabetes Self-Management Education And Support Within West Virginia From Provider Viewpoints, Kasey M. Yost

Graduate Theses, Dissertations, and Problem Reports (ETD)

Diabetes is a chronic health condition that affects millions of Americans. It can have significant, lasting effects on an individual’s mental and physical wellbeing, especially when it goes unmanaged or untreated. Diabetes has been a growing problem in West Virginia (WV), which has the highest adult rate of diabetes at 15.7% in the US. Furthermore, WV has the highest mortality rate associated with diabetes at 36.2%. An effective method of management is through diabetes self-management education and support (DSMES). DSMES is a critical component of care for all individuals with diabetes. It is defined as the ongoing process of facilitating …

Global Engagement Model For Land-Grant Universities, A Grounded Theory., Lorena Ivonne Ballester

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study is to examine how land-grant universities engage with the public in the era of globalization; to explain the institutionalization of engagement processes accounting for the global context; and, to integrate this analysis into a Global Engagement Model for Land-Grant Universities (GEM) implementing a grounded theory research methodology.

GEM’s foundation is both theoretical and empirical. Applying the intensity sampling method, the universities selected for the empirical base were: The University of California, Davis, Michigan State University, and The Pennsylvania State University. Rather than an exact representation of individual universities’ engagement models, the model is the researcher’s …

The Mercury 2022

The Mercury

No abstract provided.

Using Complex Behavior To Understand Brain Mechanisms In Health And Disease, Cassandra D. Gipson, Paul L. Soto, Erin S. Calipari, Donna M. Platt, John D. Salamone, Rick A. Bevins

Department of Psychology: Faculty Publications

At this point in the history of the science of behavior, a focus on neuroscience-based outcomes has become dominant in neuropsychiatric fields at the preclinical and clinical levels of analysis. The notion that behavior is caused by brain function, and that changing brain function can alter behavior, has fueled this push to understand these neurobiological mechanisms. Within this conceptual framework and the funding to incentivize its adoption, the neuroscience field grew rapidly with the goal to understand the relation between the brain and behavior. As such, a reductionist perspective emerged whereby neural manipulations of increasing sophistication became required for assessing …

Tolerance And Adaptability Of Tomato Genotypes To Saline Irrigation, Carlos Eduardo Da Silva Oliveira, Tiago Zoz, Arshad Jalal, Eduardo Pradi Vendruscolo, Thiago Assis Rodrigues Nogueira, Arun Dilipkumar Jani, Marcelo Carvalho Minhoto Teixeira Filho

Biology, Agriculture and Chemistry Faculty Publications and Presentations

High salt concentration in irrigation water is often a limiting factor to tomato production in Brazil. However, there is limited information available regarding the tolerance of tomato genotypes to saline irrigation. An experiment was conducted in a protected environment using a randomized block design with four replications. Treatments consisted of 12 tomato genotypes cultivated in an environment with varying levels of salt stress. Moderate and severe salt stress affected plant height, transversal and longitudinal diameter of fruit, fresh mass, yield, and number of tomato fruit per plant. Cluster analysis, stability, and adaptability provided the best estimates to identify the most …

Composted Sewage Sludge Application In A Sugarcane Seedling Nursery: Crop Nutritional Status, Productivity, And Technological Quality Implications, Rafael Dos Santos Silva, Arshad Jalal, Raimunda Eliane Nascimento Do Nascimento, Nathércia Castro Elias, Karen Cossi Kawakami, Cassio Hamilton Abreu-Junior, Fernando Carvalho Oliveira, Arun Dilipkumar Jani, Zhenli He, Fengliang Zhao, Marcelo Carvalho Minhoto Teixeira Filho, Raffaella Rossetto, Gian Franco Capra, Thiago Assis Rodrigues Nogueira

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Composted sewage sludge (CSS) contains large amounts of organic matter and nutrients and can be used as an organic fertilizer to improve growth, yield, and quality of sugarcane. However, there is a lack of information regarding the impact of CSS application on sugarcane seedling performance in nursery environments. A field study was conducted using a randomized complete block design to evaluate the development, nutritional status, productivity, and technological quality of sugarcane seedlings after CSS application with or without mineral fertilizer. Morphological variables (stem height, diameter, and number, as well as leaf area), technological attributes (total recoverable sugar: ATR; quantity of …

In Sickness And In Health: Interactions Between Romantic Dyads, Power, And Health, Madisen Taylor Reasonover

UNF Graduate Theses and Dissertations

The current study applied the Actor-Partner Interdependence Model (Cook & Kenny, 2005) to assess influence in romantic dyads regarding health attitudes and behaviors (exercise, eating), and the moderating effects of gendered power. Associations between dyad similarity scores on health attitudes, health behaviors, and gendered relationship quality was also explored. Forty-five heterosexual romantic couples who were exclusively dating (72% White/Caucasian; age M = 22.3 years; relationship length M = 28.7 months) completed several questionnaires including: the Relationship Power Inventory – Overall (Farrell et al., 2015), the Perceived Relationship Quality Components Inventory (Fletcher et al., 2000), a modified Exercise Identity Scale (Anderson …

Samaki Salama - Promoting Healthy Child Growth And Sustainable Fisheries In Coastal Kenya: A Study Protocol, Ivy Blackmore, Andrew Wamukota, Elizabeth Kamau-Mbuthia, Austin T. Humphries, Carolyn Lesorogol, Rachel Cohn, Catherine Sarange, Francis Mbogholi, Clay Obata, Christopher Cheupe, Joaquim Cheupe, Lisa Sherburne, Melissa Chapnick, Mary Kate Cartmill, Lora L. Iannotti

Fisheries, Animal and Veterinary Sciences Faculty Publications

Background: One in five young children globally suffer the consequences of stunted growth and development and millions experience deficiencies in zinc, iron, iodine, vitamins A and B12, nutrients found bioavailable in fish foods. Small-scale fisheries have the potential to generate income and augment fish consumption while being environmentally sustainable if appropriately managed. However, those engaged in small-scale fisheries are often marginalized, poor, and malnourished. The Samaki Salama project seeks to better understand and address these challenges through a three-arm, longitudinal matched cluster study which evaluates the impact of an integrated nutrition social marketing and modified fishing trap intervention.

Methods …

Safety, Feasibility And Initial Efficacy Of An App-Facilitated Telerehabilitation (After) Programme For Covid-19 Survivors: A Pilot Randomised Study, Jacob J. Capin, Sarah Jolley, Mary Morrow, Meghan Connors, Kristine Hare, Samantha Mawhinney, Amy Nordon-Craft, Michelle R. Rauzi, Sheryl Flynn, Jennifer Stevens-Lapsley, Kristine M. Erlandson

Physical Therapy Faculty Research and Publications

Objectives Determine the safety, feasibility and initial efficacy of a multicomponent telerehabilitation programme for COVID-19 survivors.

Design Pilot randomised feasibility study.

Setting In-home telerehabilitation.

Participants 44 participants (21 female, mean age 52 years) discharged home following hospitalisation with COVID-19 (with and without intensive care unit (ICU) stay).

Interventions Participants were block randomised 2:1 to receive 12 individual biobehaviourally informed, app-facilitated, multicomponent telerehabilitation sessions with a licenced physical therapist (n=29) or to a control group (n=15) consisting of education on exercise and COVID-19 recovery trajectory, physical activity and vitals monitoring, and weekly check-ins with study staff. Interventions were 100% remote and …

The Direct Care Workforce Crisis: Factors Affecting Employee Retention And Turnover Amidst A Pandemic, Rebecca Green

SPNHA Review

The purpose of this research paper is to explore the crisis currently affecting the stability of the direct care workforce within the healthcare industry of the United States. Direct care workers provide personal care assistance to individuals in nursing facilities, home health settings, community-based programs, and to persons with intellectual or developmental disabilities. The purpose of this role and the demographics of these types of employees will be explored. The history of this profession, as well as its growing demand, as they contribute to the workforce crisis will be examined. Factors contributing to employee retention and turnover will also be …

In Situ Treatment Technologies For Pit Latrines To Mitigate Groundwater Contamination By Fecal Pathogens: A Review Of Recent Technical Advances, Shray Saxena, Walter Den

Water Resources Science and Technology Faculty Publications (Archived)

On-site sanitation systems such as pit latrines are extensively used around the world, while there is a growing number of evidence documenting the impact of pit latrines on groundwater quality that may affect human health. Hence, this paper summarizes the various safe-sanitation technologies by broadly categorizing them into fecal pathogen disinfection methods (anaerobic digestion, chemical disinfection, biological additives, solar pasteurization and vermicomposting) and capturing methods (pit lining and permeable reactive barriers, the latter of which simultaneously capture and sanitize fecal sludge in pit latrines). While some of the reviewed technologies have been widely practiced for mitigating microbial contamination of the …

Socioeconomic, Clinical, And Molecular Features Of Breast Cancer Influence Overall Survival Of Latin American Women, Liz Maria De Almeida, Sandra Cortés, Marta Vilensky, Olivia Valenzuela, Laura Cortes-Sanabria, Mirian De Souza, Rafael Alonso Barbeito, Eliana Abdelhay, Nora Artagaveytia, Adrian Daneri-Navarro, Andrea S Llera, Bettina Müller, Osvaldo L Podhajcer, Carlos Velazquez, Elsa Alcoba, Isabel Alonso, Alicia I Bravo, Natalia Camejo, Dirce Maria Carraro, Mónica Castro, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raul Delgadillo-Cristerna, Lucia Delgado, Marisa Dreyer Breitenbach, Elmer Fernández, Jorge Fernández, Wanda Fernández, Ramon A Franco-Topete, Fancy Gaete, Jorge Gómez, Leivy P Gonzalez-Ramirez, Marisol Guerrero, Susan A Gutierrez-Rubio, Beatriz Jalfin, Alejandra Lopez-Vazquez, Dora Loria, Silvia Míguez, Andres De J Moran-Mendoza, Gilberto Morgan-Villela, Carina Mussetti, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Rui M Reis, Javier Retamales, Robinson Rodriguez, Cristina Rosales, Efrain Salas-Gonzalez, Laura Segovia, Juan M Sendoya, Aida A Silva-Garcia, Stella Viña, Livia Zagame, Beth Jones, Moysés Szklo, United States-Latin American Cancer Research Network (Us-Lacrn)

Faculty, Staff and Students Publications

Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60-month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by …

The Rumertime Process As A Protective Factor In School Attendance Problems, Yvonne Larrier, Monica Allen, Arline Edwards-Joseph, Geneva Fleming, Vanessa Kelleybrew

Faculty Research, Scholarly, and Creative Activity

The RUMERTIME Process (RP) is a five-step culturally responsive social-emotional, problem-solving, prevention-intervention strategy used to educate, equip, and empower students, educators, and families. The RP equips individuals with the abilities to recognize, understand, manage, express, and reflect on their thoughts, interactions, mindsets, and emotions (RUMERTIME) in relation to themselves, others, and the daily life challenges they face within multiple systems and settings. The RP is embedded within the Cultivating SEEDS System framework (CSS) and is utilized to equip culturally diverse communities, inclusive of students, family members, educators, and administrators, with the social-emotional skills to effectively solve student attendance problems (SAPs). …

Spanish-Speaking Caregivers’ Use Of Referential Labels With Toddlers Is A Better Predictor Of Later Vocabulary Than Their Use Of Referential Gestures, Janet Y. Bang, Manuel Bohn, Joel Ramírez, Virginia A. Marchman, Anne Fernald

Faculty Research, Scholarly, and Creative Activity

Variation in how frequently caregivers engage with their children is associated with variation in children's later language outcomes. One explanation for this link is that caregivers use both verbal behaviors, such as labels, and non-verbal behaviors, such as gestures, to help children establish reference to objects or events in the world. However, few studies have directly explored whether language outcomes are more strongly associated with referential behaviors that are expressed verbally, such as labels, or non-verbally, such as gestures, or whether both are equally predictive. Here, we observed caregivers from 42 Spanish-speaking families in the US engage with their 18-month-old …

Blackcurrants: A Nutrient-Rich Source For The Development Of Functional Foods For Improved Athletic Performance, Ali Ali Redha, Shahida Anusha Siddiqui, Reza Zare, Daniele Spadaccini, Silvia Guazzotti, Xi Feng, Nur Alim Bahmid, Yuan Seng Wu, Fathima Zahraa Ozeer, Rotimi E. Aluko

Faculty Research, Scholarly, and Creative Activity

Blackcurrants are nutrient-rich fruits with a significant amount of bioactive compounds including vitamin C and polyphenols, especially anthocyanins. The high phytochemical content of blackcurrants promotes this fruit to become a valuable functional food ingredient with varying health-promoting activities targeting different consumers including athletes. Athletes experience oxidative stress during intense exercise, which can result in inflammation and reduced exercise performance. Antioxidants such as vitamin C and polyphenols can restore the regular oxidative status of the body. Blackcurrant supplementation has shown potential ergogenic activity to improve athlete performance during high-intensity training. Clinical trials have evaluated the effectiveness of blackcurrant supplementation on exercise …

A Qualitative Study Of Emergency Department Delirium Prevention Initiatives, Anita Chary, Shan W Liu, Ilianna Santangelo, Kyler M Godwin, Christopher R Carpenter, Aanand D Naik, Maura Kennedy

Faculty, Staff and Students Publications

BACKGROUND: Delirium is a serious but preventable syndrome of acute brain failure. It affects 15% of patients presenting to emergency care and up to half of hospitalized patients. The emergency department (ED) often represents the entry point for hospital care for older adults and as such is an important site for delirium prevention.

OBJECTIVE: We sought to characterize delirium prevention initiatives in EDs in the United States and Canada.

METHODS: We conducted qualitative interviews with 16 ED administrators representing 14 EDs with delirium prevention initiatives. We used a combined deductive-inductive approach to code responses about involved staff, target patient population, …

Eating Disorders In Adolescents: Facts And Recommendations For The Oral Health Care Team, Catherine A. Miller Md, James R. Boynton Dds, Ms, Terrill Bravender Md, Mph

The Journal of the Michigan Dental Association

Eating disorders typically begin during the adolescent years. These disorders are a spectrum of thoughts and behaviors related to food, weight and exercise that lead to significant psychological and physical morbidity. Medical complications of eating disorders are common and can be life-threatening. Dental providers can play an important role in care by recognizing oral signs and symptoms associated with eating disorders, giving advice on mitigating these issues, and helping patients and families connect with appropriate care. In this article, we provide key information about eating disorders, the complications including oral health issues, and advice for dental providers regarding care and …

Childhood Obesity Interventions In The Republic Of Trinidad And Tobago: A Qualitative Study Exploring Government Policies And Their Implementation By Health Practitioners, Phyllis Woolford

Dissertations

Because of the rising prevalence of childhood obesity and overweight in the Republic of Trinidad and Tobago, and the observation that efforts to address the problem were showing disappointing results, this study seeks to explore the experiences and views of policymakers, health practitioners, and parents of overweight and obese children, in order to inform leaders and policy makers regarding the current interventions.

Method

A qualitative research case study methodology is the research design used, which, with my research questions, I considered would best uncover knowledge and provide perspectives that would provide an increased understanding of the issues arising from the …

Policymaker Discourse In Colorado Public Higher Education Appropriations, Nathan Willers

Electronic Theses and Dissertations

State funding for higher education is one of the most pressing issues facing both institutions and policymakers in 2022. Colorado has seen significant declines in the amount of state funding per student over the past two decades, resulting in increases in student burdens for tuition. Policy discourse analysis through a poststructural and neoliberal lens provided insight towards the legislative process and the discursive themes utilized by Colorado policymakers during the 2021-22 legislative budgeting cycle. Twelve artifacts were analyzed, including a mix of policy briefs, hearings, and budget and appropriations reports, for discursive data related to the state’s appropriations for public …

Physical Activity And Diet Quality In Relation To Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study In A Representative Sample Of Us Adults Using Nhanes 2017–2018, Natalia I Heredia, Xiaotao Zhang, Maya Balakrishnan, Carrie R Daniel, Jessica P Hwang, Lorna H Mcneill, Aaron P Thrift

Faculty, Staff and Students Publications

The association of physical activity (PA) and diet quality with non-alcoholic fatty liver disease (NAFLD) and NAFLD-related fibrosis have never been examined in a representative sample of U.S. adults using a more precise form of measuring NAFLD. The purpose of this study was to assess the associations of PA and diet quality (Healthy Eating Index [HEI]-2015) with NAFLD and a subset with advanced fibrosis (F3-4) as assessed by vibration-controlled transient elastography with controlled attenuation parameter in a representative sample of U.S. adults. This cross-sectional analysis uses data from 2017-2018 National Health and Nutrition Examination Survey. NAFLD was defined as controlled …

Severe Inflammatory Colitis Related To Encorafenib And Binimetinib Following Immune Checkpoint Inhibitor Therapy, Aaron G Issac, David Szafron, Dongguang Wei, Jennifer L Mcquade, Yinghong Wang

Faculty, Staff and Students Publications

Encorafenib, a BRAF kinase inhibitor, in combination with binimetinib, a selective MEK inhibitor have known gastrointestinal adverse events; however, adverse colitis events have not been well studied. We report a case series of 4 patients with melanoma who developed inflammatory colitis after BRAF and MEK inhibition with encorafenib and binimetinib, respectively. In the setting of immune checkpoint inhibitor use, BRAF and MEK inhibitors can cause significant inflammatory colitis with endoscopic patterns of predominant right colon ulcerations. It can lead to significant morbidity and frequent interruption of cancer treatment. Early recognition and prompt intervention are critical to improving patient outcomes.

Cytomegalovirus Infection Among Patients With Cancer Receiving Immune Checkpoint Inhibitors, Kavea Panneerselvam, David Szafron, Rajan N Amin, Dongguang Wei, Dongfeng Tan, Mehmet Altan, Pablo C Okhuysen, Malek Shatila, Gottumukkala Subba Raju, Anusha S Thomas, Yinghong Wang

Faculty, Staff and Students Publications

BACKGROUND: Immune checkpoint inhibitors (ICIs), used for the treatment of solid and hematologic malignancies, come with the risk of immune-related adverse events (irAEs). Opportunistic infections (e.g., cytomegalovirus [CMV]) mimic irAE symptoms and are understudied in this population. We aimed to describe the incidence, characteristics, treatment and outcomes of CMV infection in ICI-treated patients.

METHODS: We conducted a single-center retrospective review of all adult patients who were CMV-positive after ICI therapy between 06/2011 and 05/2020. A CMV-positive non-ICI cohort was matched to the ICI group based on age, sex and cancer type. Variables of interest were collected through electronic medical records. …

Economic Influence Activities And The Strategic Location Of Investment, John M. De Figueiredo, Davin Raiha

Faculty Scholarship

This article examines the economic influence activities (EIAs) of firms. We argue that firms invest in jobs and establishments in districts of congressional committee members that have oversight over their businesses and industries. This investment increases as legislators’ power rises in Congress. Our theory makes three predictions. First, EIAs by firms will be higher in congressional districts where the legislators have substantial political influence over the firm, relative to districts where legislators have little influence over the firm. Second, EIAs will increase with the legislators’ power on the focal committee. Third, when a legislator exits the committee, EIAs will diminish, …

Inpatient Coding System And Opportunities For Documentation Optimization: An Interactive Session For Internal Medicine Residents, Lindsey Jordan Gay, Doris Lin, Ziba Colah, Glynda Raynaldo

Faculty, Staff and Students Publications

INTRODUCTION: The Inpatient Prospective Payment System, the framework for categorization of admissions, is based upon physician documentation leading to International Classification of Diseases, Tenth Revision code generation and Medical Severity Diagnosis-Related Group (MS-DRG) assignment. In this curriculum, we introduced internal medicine residents to this inpatient coding framework and its effects on hospital quality metrics and reimbursement. We focused on educating learners about the importance of physicians being proficient in providing thorough and specific clinical documentation to produce appropriate DRG assignment.

METHODS: Internal medicine residents participated in a 90-minute session that introduced the basic framework of inpatient coding, discussed effects of …

Moral Economies Of Family Reunification In The Trump Era: Translating Natural Affiliation, Autonomy, And Stability Arguments Into Constitutional Rights, Kerry Abrams, Daniel Pham

Faculty Scholarship

No abstract provided.

Esophageal Perforation Successfully Treated With Evt, Kavea Panneerselvam, Ronald Samuel, Robert J Sealock

Faculty, Staff and Students Publications

Esophageal perforation is rare and carries high morbidity and mortality. A high degree of suspicion is needed for timely diagnosis and treatment. A 54-year-old man presented with fever and confusion. Imaging revealed air in the hepatic inferior vena cava and concern for a fistula between the distal esophagus and the inferior vena cava. An upper endoscopic evaluation revealed a dental floss pick penetrating the distal esophagus. The foreign body was removed, and endoluminal vacuum therapy was used to close the perforation. Endoluminal vacuum therapy is an emerging therapy to treat full-thickness gastrointestinal injuries.