Digital Commons Network^™

Tyrosine Phosphatase Ptpro Deficiency In Erbb2-Positive Breast Cancer Contributes To Poor Prognosis And Lapatinib Resistance., Hongmei Dong, Liang Du, Songwang Cai, Wan Lin, Chaoying Chen, Matthew Still, Zhimeng Yao, Robert P Coppes, Yunlong Pan, Dianzheng Zhang, Shegan Gao, Hao Zhang

PCOM Scholarly Works

Despite the initial benefit from treating ERBB2-positive breast cancer with tyrosine kinase inhibitor lapatinib, resistance develops inevitably. Since the expression of protein tyrosine phosphatase receptor-type O (PTPRO), a member of the R3 subfamily of receptor protein tyrosine phosphatases (PTPs), is inversely correlated with the aggressiveness of multiple malignancies, we decided to explore the correlation between PTPRO and lapatinib resistance in ERBB2-positive breast cancer. Results of immunohistochemical (IHC) staining and the correlation analysis between the expression levels of PTPRO and the clinicopathological parameters indicate that PTPRO is downregulated in cancer tissues as compared with normal tissues and negatively associated with differentiation, …

Foxo1 Is Present In Stomach Epithelium And Determines Gastric Cell Distribution, Wendy M Mckimpson, Taiyi Kuo, Takumi Kitamoto, Sei Higuchi, Jason C Mills, Rebecca A Haeusler, Domenico Accili

Faculty, Staff and Students Publications

BACKGROUND AND AIMS: Stomach cells can be converted to insulin-producing cells by Neurog3, MafA, and Pdxl over-expression. Enteroendocrine cells can be similarly made to produce insulin by the deletion of FOXO1. Characteristics and functional properties of FOXO1-expressing stomach cells are not known.

METHODS: Using mice bearing a FOXO1-GFP knock-in allele and primary cell cultures, we examined the identity of FOXO1-expressing stomach cells and analyzed their features through loss-of-function studies with red-to-green fluorescent reporters.

RESULTS: FOXO1 localizes to a subset of Neurog3 and parietal cells. FOXO1 deletion ex vivo or in vivo using Neurog3-cre or Atp4b-cre increased numbers of parietal cells, …

Mending Art Classrooms: An Exploration Of The Benefits Of Collaborative Artmaking For Underinvested Black Youth In Richmond, Virginia, Jazmine M. Beatty

Theses and Dissertations

This arts-informed research study explored the experiences of local community artists and educators working to radically transform and heal the experiences of underinvested Black students in Richmond through collaborative arts engagement. Through a series of seven one-on-one interviews with Black teaching artists in the Richmond community, I was able to uncover how collaboration has and can continue to improve the well-being and livelihoods of Black students in Richmond. Also, by tapping into the local Mending Walls mural project, I was able to make a tangible connection between the Richmond community, art, and collaboration. An analysis of the interviews led to …

The Civil Right To Belong: A Case Study On Immigrant Integration Of Muslim Students In Educational Institutions, Mamoona H. Siddiqui

Theses and Dissertations

Constitutional equal protection values serve as social integration policies for new Americans and generations that follow. They promise equal opportunity, fair treatment, protection from unlawful discrimination, and freedom to preserve cultural identities in their new communities. However, in times of national security crises and political polarization, the disjuncture in the way equal protection doctrines have been historically implemented often reflect deep-rooted inequities that impact underrepresented communities. American Muslims are one such community in which members have experienced anti-Muslim and anti-immigrant sentiment particularly after 9/11 and political polarization on immigration and civil rights policies. The study explores the equal protection doctrine …

She: Performing Biography As A Dramatic Narrative, Ashley J. Love

Theses and Dissertations

Abstract

SHE: PERFORMING BIOGRAPHY AS DRAMATIC NARRATIVE

By Ashley Love, Master of Fine Arts at Virginia Commonwealth University

Partial Fulfillment Statement:

Thesis submitted in partial fulfillment of the requirement for a Master of Fine Arts in Theatre Pedagogy at Virginia Commonwealth University.

Director: Dr. Aaron Anderson

Interim Director of Graduate Studies, Theatre Department

Amid the current wave of feminism, women continue to strive for equal ground within societal constructs. Progress is being made in the workplace, the arts, and media presence, but why does it seem that women’s stories of the past continue to be overlooked as if insignificant? This …

Are Pharmacists Up To Speed?: Pharmacy Driven Initiatives, Allison Vargas

All Publications

No abstract provided.

An Analysis Of Air Traffic Controllers’ Job Satisfaction, Sohel M. Imroz, Farhan Sadique, Nidhi Trambadia

Journal of Aviation/Aerospace Education & Research

The air traffic controllers' job is one of the most hectic in today’s world, predominantly due to its safety-critical operations and altering expectations. The primary purpose of this paper is to provide a holistic directory of determinants and synthesized reinforcements for air traffic controllers' job satisfaction. Researchers in the past have put the spotlight on individual air traffic controller’s technical job satisfaction factors, such as impacts from remote tower operation, airplane trajectory changes, and dynamic air traffic situations. However, none described the connection among those factors and how adjusting those factors can enhance the cognitive components related to their job …

Hostos Community College Academic Bulletin 2022-2023, Hostos Community College

College Bulletins

This is the official college catalog for 2022-2023. It contains course descriptions as well as information on degree programs, college resources and services, financial aid, admissions, and the academic calendar.

Alex Birnel, Carly Bagley

Latinx Civil Rights

Alex Birnel shares his experience organizing young voters and helping create the organization MOVE Texas. Birnel also discusses providing voter education to other young voters in the San Antonio area during his time as a college student as well as inviting the local community to participate in civic engagement outside the university campus.

Elisha Carillo, Madeline Emke

Latinx Civil Rights

Elisha Carrillo talks about their motivations for being involved with MOVE Texas and serving as a deputy field organizer. Elisha explains their first interactions with MOVE as a student at St. Mary’s University and finding an interest in voter advocacy through local elections in the area. Elisha discusses their current position working with MOVE Texas in the San Antonio area as the Bexar County Regional Coordinator and organizing community events regarding local elections and voter education.

Charles Cotrell, Analyssa Gracía, Gabriella Parra

Latinx Civil Rights

Dr. Cotrell discusses the motivations for his activist work and the experiences he faced as a professor and community leader. He recalls cases from his time serving as an expert witness in voting rights lawsuits and notes the importance of telling stories of voter intimidation. Dr. Cotrell shares his thoughts on staying proactive in politics, gives advice to young activists, and describes how university faculty can support students in their activism. He also reflects on his personal interests and those that occupied most of his time as a professor.

Claudia Donoso, Juan Ochoa

Latinx Civil Rights

Dr. Donoso discusses a variety of topics centered around immigration. She highlights the immigration process and lack of adequate resources for immigrants while also going into depth about political and economic factors. Dr. Donoso shares both personal and professional perspectives of immigration.

Oscar Lazaro, Ashton Jeffers

Latinx Civil Rights

Oscar Lazaro shares his experience working as a fellow for the Student Voting Network as well as his observations about voting and democracy. He describes how he started his podcast as well as lessons he has learned from producing it. He also details how he addresses difficult topics with others who may disagree with him.

Natalie Marquez, Ashton Jeffers

Latinx Civil Rights

Natalie Marquez explains the work she does for Jolt Action and the ways Jolt is involved in the San Antonio Latinx community. Marquez describes how social and political issues in Texas personally affect her and her family. She also shares how to make voting a cultural norm and practice in the Latinx community.

Meghann Peace, Calie Brame

Latinx Civil Rights

Dr. Peace discusses the process of becoming a volunteer at RAICES and the training she received through the organization. She recounts personal stories about the poor conditions immigrants endured in detention centers. Dr. Peace also explains how RAICES helps people through the legal process of immigration

Amir Samandi, Megan Angelo, Elizabeth Perez

Latinx Civil Rights

Amir Samandi describes his high school experiences including attending a predominately white school as a person of color. He mentions the efforts of teachers who supported him in pursuing higher education. Amir also discusses his undergraduate education at St. Mary’s University and the environment of the community. He then explains how his career led him to create a nonprofit that focuses on young students and how his personal experience connects with the organization's mission.

Assessing Phenotypic Response Of Plants Irrigated With Municipal Solid Waste Landfill Leachate Using Computer Visualization, Rahel Pommerenke

Masters Theses

"Most solid waste collected in the US is disposed of in sanitary landfills, which have a lingering legacy of unintended negative impacts on the environment. Landfill design and operation are expensive, prone to multiple failure modes, and often do not address human and ecological risks presented by contaminants of emerging concern. A notable and common failure mechanism is leachate production. Moisture in the waste mixes with infiltrating water to form wastewater that must be collected and treated prior to discharge. Recycling leachate at landfills by recirculating it onto vegetated landfill covers relies on the evapotranspiration potential of plants to reduce …

Using Internet Reciprocal Teaching To Develop Second Graders' Online Text Evaluation Skills, Annika Buell

Dissertations and Theses @ UNI

This study was designed to explore the relationship between Internet Reciprocal Teaching (IRT) and young students’ online text evaluation skills. It built upon previous research that identified four main online reading comprehension skills: locating, evaluating, synthesizing, and communicating information that are similar yet more complex than offline reading comprehension skills. In the majority of previous research, participants were in fifth grade or above. This study aimed to observe the processes younger students go through while reading online text. Participants were second grade students in a Midwestern suburban elementary school.

Qualitative methods were used to collect data while students participated in …

Gender Performance And Political Identity At The January 6 Capitol Insurrection, Emma Elise Newton

Dissertations and Theses @ UNI

The January 6 Capitol insurrection was heavily documented with recorded videos and photos, across legacy and social media. Despite engaging in criminal acts, many participants recorded themselves participating in the attack and posted their videos to Parler, a right-wing alternative to Facebook and Twitter that gained traction among the far-right, QAnon conspiracy theorists, and white supremacy groups. These social media videos detail an interesting rhetorical dynamic at play, one that is not so recognizable in legacy media: performances of sex/gender. Analyzing videos uploaded to a conservative social media landscape provides a lens into performances of gender as it intersects with …

Effects Of Perceived Reach On Ratings Of Media Bias, Quality, And Agreement, Matthew Sedlacek

Dissertations and Theses @ UNI

The hostile media effect refers to individuals’ tendencies to perceive seemingly neutral news coverage as biased against their stance (Vallone et al., 1985). Research has shown this effect in partisan politics, with liberals and conservatives perceiving bias in information presented from the opposing side. The current study examined the effects of liberal or conservative and small or large audience news source manipulations on liberals’ and conservatives’ perceptions of media bias and the relationship between partisan identity and perceptions of bias. Three hundred and sixty participants read a news article presented with either a Fox News, CNN, PatriotNewsDaily, or The Progressive …

Lexile Levels And Their Value To Public School Teachers, Kristin Schumacher

Dissertations and Theses @ UNI

This thesis examines how teachers perceive Lexile level and its value, and whether or not their beliefs inform their practice. To address questions regarding teachers’ beliefs about Lexile level, I designed and implemented an online survey for public school teachers. My research shows that teachers have a favorable view of Lexile level, that they believe both students and parents should be informed of students’ Lexile level, that books should be labeled with Lexile level, and that asking students to read within their Lexile level range is a good practice. This survey research reveals the need to further interrogate whether or …

The New Independents: A Historical Analysis Of Webcomics And Webtoon, Leonal A. Sepúlveda S.

Dissertations and Theses @ UNI

Webcomics have now existed as a form of graphic literature for slightly over thirty years, evolving along with computer technology and in turn reflecting the changes in culture, style and preferences for both independent artists on the Internet and their audiences. The evolution of the webcomic illustrates how the changing trends in technology and profit interests shape stylistic and narrative sensibilities. In turn, the offshoot medium of webtoons, whose history parallels the webcomic directly, illustrates the way the presentday independent webcomic sphere is shaped by the demands of contents platforms that demand its creatives constantly produce content to maintain active …

Weaving Academic Grace Into The Fabric Of Online Courses And Faculty Training: First-Year Engineering Student Advice For Online Faculty During The Covid-19 Pandemic And Faculty Responses, Michelle E. Jarvie-Eggart, Amanda Marie Singer, Marika Seigel, Mary Raber, Thomas M. Freeman, Brett Hamlin, Amy Hamlin, Michael R. Meyer

Michigan Tech Publications, Part 1

Background: In the spring of 2020, COVID-19 forced the majority of higher education online, resulting in a wave of new online students uniquely positioned to offer fresh perspectives and advice to faculty.

Purpose: This study investigated the advice offered to online faculty by first-year engineering (FYE) students who were forced online during the pandemic and faculty ideas to address the student advice.

Methods: This multi-methods study included qualitative data from 233 FYE students (in 67 teams across four class offerings) who provided advice for online faculty through an end-of-year team assignment, leveraging analytic induction methods for analysis. The Quality Matters …

Interleukin-1Β Secretion Induced By Mucosa-Associated Gut Commensal Bacteria Promotes Intestinal Barrier Repair, Wan-Jung H Wu, Myunghoo Kim, Lin-Chun Chang, Adrien Assie, Fatima B Saldana-Morales, Daniel F Zegarra-Ruiz, Kendra Norwood, Buck S Samuel, Gretchen E Diehl

Faculty, Staff and Students Publications

The gut microbiota is essential for maintenance and repair of the intestinal epithelial barrier. As shifts in both intestinal epithelial barrier function and microbiota composition are found in inflammatory bowel disease patients, it is critical to understand the role of distinct bacteria in regulating barrier repair. We identified a mouse commensal E. coli isolate, GDAR2-2, that protects mice from Citrobacter rodentium infection and dextran sulfate sodium-induced colitis. Colonization with GDAR2-2 in mice resulted in expansion of CX3CR1+ mononuclear phagocytes, including CX3CR1+ macrophages/dendritic cells and monocytes, along with IL-22-secreting type 3 innate lymphoid cells and improved epithelial barrier function. In vitro …

Removing Carbon Dioxide Through Ocean Fertilization: Legal Challenges And Opportunities, Korey Silverman-Roati, Romany M. Webb, Michael Gerrard

Faculty Scholarship

Carbon dioxide removal (“CDR”) will be needed, alongside deep emissions cuts, to achieve global temperature goals. According to a 2022 report by the Intergovernmental Panel on Climate Change, to keep global average temperatures within 1.5°C above preindustrial levels, carbon dioxide and other greenhouse gas emissions must reach net-zero by mid-century. Scientists have proposed a number of land- and ocean-based CDR techniques. This paper focuses on ocean fertilization, which involves adding iron or other nutrients to the ocean to stimulate the growth of phytoplankton that uptake carbon dioxide and convert it into organic carbon. The hope is that the organic carbon …

Regulation Of Polyfluoroalkyl Chemicals In New York, Michael B. Gerrard, Edward Mctiernan

Faculty Scholarship

Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are two polyfluoroalkyl chemicals (PFAS) – a class of over 7,000 compounds with unique chemical structures that repel lipids and water. As a result, PFOA and PFOS have been used in numerous household products, such as nonstick cookware and stain-resistant carpets, and commercial applications such as firefighting foam. PFOS and PFOA are frequently referred to as “emerging contaminants,” a label with no precise regulatory definition but generally understood to refer to chemicals for which there are few published standards designed to protect human health and the environment from perceived hazards. Many PFAS compounds …

Criminalized Students, Reparations, And The Limits Of Prospective Reform, Amber Baylor

Faculty Scholarship

Recent reforms discourage schools from referring students to criminal law enforcement for typical disciplinary infractions. Though rightly celebrated, these reforms remain mere half-measures, as they emphasize prospective decriminalization of student conduct without grappling with the harm to generations of former students – disproportionately Black – who have been targeted by criminalizing policies of the past. Through the lens of reparations theory, this Article sets out the case for retroactive and reparations-based redress for the criminalization of students. Reparations models reposition moral norms. They acknowledge state harm, clarify the losses to criminalized students, allow for expansive forms of redress, and cast …

The Banker Removal Power, Da Lin, Lev Menand

Faculty Scholarship

The Federal Reserve (“the Fed”) can remove bankers from office if they violate the law, engage in unsafe or unsound practices, or breach their fiduciary duties. The Fed, however, has used this power so rarely that few even realize it exists. Although major U.S. banks have admitted to repeated and flagrant lawbreaking in recent years, the Fed has never removed a senior executive from one of these institutions.

This Article offers the first comprehensive account of the banker removal power. It makes four contributions. First, drawing on a range of primary sources, it recovers the power’s statutory foundations, showing that …

Fast Cbt For Pediatric Ocd: A Multiple-Baseline Controlled Pilot Trial Of Parent Training In Exposure And Response Prevention Delivered, Lara J Farrell, Natalja A Nabinger De Diaz, Sharna Mathieu, Matthew L Mckenzie, Taka Miyamoto, Caroline L Donovan, Allison M Waters, Sonja March, Nicole Bothma, Rianca Kroon, Gabrielle Simcock, Robert S Ware, Robert R Selles, Eric A Storch, Thomas Ollendick

Center for Medical Ethics and Health Policy Staff Publications

Objective: The current study utilized a single case series, non-concurrent multiple baseline design to examine the efficacy of training parents via telehealth videoconferencing in exposure and response prevention (ERP) for home delivery of the treatment for their children and adolescents with obsessive compulsive disorder (OCD).

Method: There were nine participants aged 8 to 14 years who had received a primary diagnosis of OCD. The design involved a series of AB replications, whereby following pre-treatment assessments participants were randomly assigned to either a 2-week (n = 4) or 3-week (n = 5) baseline condition with weekly monitoring of their …

Evaluation Of Single-Cell Cavities Made Of Forged Ingot Niobium At Jefferson Lab, P. Dhakal, Bashu D. Khanal, Gianluigi Ciovati, G. R. Myneni

Physics Faculty Publications

Currently, fine grain niobium (Nb) (grain size ∼ 50 µm) and large grain Nb (grain size of a few cm) are being used for the fabrication of superconducting radio frequency (SRF) cavities. Medium grain forged ingot with grain size of a few hundred µm may be beneficial for cost-effectiveness as well as providing better performance for future SRF-based accelerators. Forged ingot Nb with medium grain size is a novel production method to obtain Nb discs used for the fabrication of superconducting radio frequency cavities. We have fabricated two 1.5 GHz single cell cavities made from forged Nb ingot with a …