Digital Commons Network^™

Measuring Macroeconomic Shocks Of The Covid-19 Pandemic: An Empirical Analysis For Bhutan, Lekey Dorji

Theses

Taking GDP growth and inflation as endogenous variables, this paper employs a Structural VAR from Baumeister and Hamilton (2015, 2019) to identify aggregate demand and aggregate supply shocks for Bhutan, focusing on the COVID-19 pandemic. The results suggest that 94 percent of the GDP growth plunge in 2020 is attributable to a fall in aggregate supply. The higher inflation during the COVID-19 pandemic in 2020 also implies a negative supply shock. Although the magnitudes differ, characterizing the COVID-19 pandemic in Bhutan as a supply shock coincides with preceding episodes that were also primarily driven by supply shocks.

Social Media And Body Image: Social Media Intensity And Self-Perceived Body Image, Claire Sharp

Undergraduate Honors Theses

Social media remains a popular form of communication making it important to look at this form of communications effect on users. Previous research has shown mixed results in finding an association between social media use and body image (Fardouly & Holland, 2018; Mackson et al., 2019; Saiphoo & Vahedi, 2019). These mixed results promote further consideration on how social media relates to body image. Social media intensity is one variable previously considered when examining social media use and an individual’s emotional connection. The current study looks at the relationship between the previously studied variable of social media intensity to less …

Heat Waves And A Public-Private Partnership In Alaska, Sarah A. Matsumoto, Karen Sandrik

Publications

No abstract provided.

Groundwater Modelling Of The Newman Area For Managed Aquifer Recharge Assessment, Wolfgang Schmid, Rodrigo Rojas, Michael J. Donn, Christopher Schelfhout Dr, Mathias Raiber, Olga Barron

Natural resources commissioned reports

This report contributes to the Transforming Agriculture in the Pilbara (TAP) initiative that has been developed to undertake the detailed studies in the Pilbara to bring suitable medium to large scale irrigation land to market for private investment. The research objective was to explore opportunities for irrigated agriculture north of Newman (Eastern Pilbara), deploying managed aquifer recharge (MAR) to secure water for irrigation. MAR source water identified was from mine dewatering surplus, generated from the large BHP Iron Ore operation in the Newman region. The objectives of this report were to:

• conceptualise the groundwater system and associated processes in the …

Exploring How Morality Framing And Partisanship Influence Public Perceptions Of Immigration, Gerardo Jesus Flores

Open Access Theses & Dissertations

The goal of this thesis research project is to provide a new theoretical outlook that explores and analyzes how morality framing may affect American political preferences and behavior. Partisanship and ideological preferences have long been acknowledged as significant predictors of political behavior in the American electorate. I posit the framing of the key issue of immigration through a moral prism can increase support for presidential proposals and may counteract or even overpower the effects of partisanship. When oneâ??s views on morality and partisanship are at odds with each other on a given issue, I expect respondents who self-identify as morally …

Achieving Safe Use Of Advanced Materials In Drinking Water Through Novel Nano Analytics And Enabling Electrification Using Green Catalyst, Kenneth Ray Flores

Open Access Theses & Dissertations

The accumulation of engineered nanomaterials (ENMs) in environmental sectors will continue to increase as more applications are discovered for their unique properties and characteristics. Additionally, the presence of nanomaterials in the environment becomes exacerbated as more consumer products containing nanoparticles are approved for use. It is debated whether the toxic effects of nanoparticles stem from the particles themselves, ionic species, or formation of secondary particles. Therefore, understanding the behavior of nanoparticles in the environment becomes key to discerning the toxicological effects of nanoparticles. Many advancements have been made with ICP-MS to understand the behavior of nanoparticles in the environmental systems, …

Direct Potable Reuse Piloting: Optimizing Chloramination, Operationalizing Ultrafiltration, And Understanding Zero Liquid Discharge Options, Marcela Carolina Herrera

Open Access Theses & Dissertations

A pilot study was deployed at the John T. Hickerson Water Reclamation facility to analyze the viability of high recovery direct potable water reuse (DPR), aiming for zero liquid discharge (ZLD). This pilot consists of a chloramination system and ultrafiltration (UF) as pretreatment for reserve osmosis (RO) followed by UV-peroxide, granular activated carbon (GAC), and concentrate-enhanced recovery reverse osmosis (CERRO). Stabilizing the chloramination and UF system was the first step to ensure efficiency during the downstream processes. The formation of monochloramine is essential for the mitigation of biofouling of the UF membranes. The formation of monochloramine occurs by specific liquid …

Security Analysis And Implementation Of Dnp3 Multilayer Protocol For Secure And Safe Communication In Scada Systems, Isaac Monroy

Open Access Theses & Dissertations

When SCADA systems were first introduced into society, a lot of manpower was required for monitoring and controlling devices within critical infrastructures. With the increasing demand for services and growing systems, a need arose to automate the monitoring and controlling tasks. This led to introduction of networks into SCADA systems to enhance monitoring and control capabilities, that can scale with system size and requirements. But this introduction of network layer along with its advantages, also introduced a new threat surface which exposed multiple vulnerabilities within the system that can exploited to launch attacks, that led to the integration of security …

The Real Face Of Borderline Personality Organization Within Intimate Partner Violence, Adriana Isabel Patino

Open Access Theses & Dissertations

This study tests the relationship between IPV perpetration and victimization with BPO. Results indicate that, as predicted, BPO is positively associated with both IPV perpetration and victimization and is more prevalent in female perpetrators and victims than in male perpetrators and victims. However, contrary to what previous literature says, self-control does not show enough significance to state that it is one of the leading causes of IPV perpetrated by those who present traits of BPO. In addition, results also indicate that having suffered from physical abuse during childhood diminishes the probability of perpetrating IPV. To fully understand these results, future …

Two Novel Piperidone Compounds Display Antiproliferative Effects On Human Prostate And Lymphoma Cancer Cell Lines And In Vitro Investigation Of Thiophenecarboxylate Anti-Cancer Activity, Risa Mia Swain

Open Access Theses & Dissertations

Tumor interactions predominantly dominate cancer progression and its tumor microenvironment. Such interactions include, tumors generating signals that cause dysfunction and death to immune cells [1]. Inflammatory and immune cells present to eliminate cancer cells fail and lose their overall function [1]. These cells lose the overall ability to aid and are co-opted to promote tumor growth. Ultimately, the result is escaping from the hosts' immune system and developing a complex mechanism that evades immune cells and the inability to undergo apoptosis. It is imperative to develop a better understanding of the complex machinery cancer develops. There are current therapies that …

Criminalization And Citizenship: How Racial Discrimination Affects U.S. Immigration Policy, Melissa Lisette Trejo

Open Access Theses & Dissertations

This paper focuses on immigration operations and policies from 1990-2008 with a focus on how these operations and policies affected the city of El Paso, Texas. The work begins with a brief introduction of immigration policies from the Chinese Exclusion Act of 1882 to the Immigration Reform and Control Act of 1986 which gave amnesty to undocumented immigrants. The research follows Bowie High School's lawsuit against the United States Border Patrol, Operation Hold the Line, and how racial scripts were used from 1990-2000. To conclude, the thesis focuses on post-9/11 legislation, criminalization and citizenship profiling, and a hearing that was …

Teachers' Perspectives On Decolonizing U.S. Curriculum For Latinx Through Ethnic Studies Programs At The Middle And High School Levels, Richard Varela

Open Access Theses & Dissertations

The purpose of this study was to understand the implementation of an ethnic studies program with an emphasis on Mexican American Studies at the middle and high school level, in a district located along the Mexican/U.S. frontera. Ethnic Studies are a critical, interdisciplinary academic field of study that acknowledges that race, and racism are embedded in every U.S. system, especially our educational institution. As a critical pedagogy, ethnic studies validate and encourages the voices and viewpoints of the marginalized, while analyzing and criticizing dominant influences that promote â??normalizingâ?? of racialized inequality (de los Rios, 2013). At the center of ethnic …

Healing Queer Trauma In A Cisheteronormative Society, Dominic Ray Vasquez

Open Access Theses & Dissertations

The birth of Pose created a space that helped to branch away from traditional queer stories that entered the mainstream. It dealt with pain, death and put Queer identities back in traumatic spaces such as survival sex work and the AIDS crisis, where we lost a generation of queer art. Nevertheless, that wasn’t the goal of the show. The goal of the show was to focus on these stories of transwomen and give them a space to be portrayed in more authentic ways. Steven Canales, the creator of Pose opted out of the same trauma filled story for something much …

Inhibiting C-C Chemokine Receptor 7 Activation Of T-Cell Acute Lymphoblastic Leukemia By A Ccl19/Macrophage Inflammatory Protein-3Β Antagonist, Angel Torres

Open Access Theses & Dissertations

The binding of C-C Chemokine Ligand 19 (CCL19) to C-C chemokine receptor 7 (CCR7) receptor has been linked to T-cell activation, tolerance, and inflammation. CCR7 is a member of the chemotactic cytokine family, essential in the development of T cells and regulatory processes such as immune-cell trafficking. This is accompanied by chemokine ligand concentration and time-dependent internalization, which is efficiently promoted by CCL19. A novel N-terminal truncation of CCL19 has been previously developed as an antagonist observed to impede induced chemotaxis and calcium mobilization in mouse primary immune cells. The current antagonist has suggested a key role of CCL198-83 in …

Compact Electrospray Propulsion Systems For Small Form-Factor Satellites: An Orbital Performance Survey & Platform Design, Alberto Meza

Open Access Theses & Dissertations

Over the past decades, small form-factor satellites such as CubeSats have remained as one of the most accessible platforms to reach space for universities, research institutions, private and governmental entities to perform a wide range of missions. This paper presents a survey into the design and implementation of an electrospray rail thruster, to be integrated to the CubeSat platform. The design investigated features propellant tanks for each individual thruster embedded inside the rail of a standard 1U CubeSat. The capabilities of utilizing the electrospray thruster as an attitude & determination control system was also investigated in which, a pointing accuracy …

Cultivating Christian Community In A Post-Covid Era, Susie M. Lloyd

Journalism

This study focuses on how to meet the needs of young adult Christians through community and resources, all of which aim to help them live more like Jesus. There are many online resources for Christians, but society lacks a “one-stop shop” website that has every resource a young adult following Jesus could need. These resources include an online community where people can choose what mode of community they need, whether that be one-on-one discipleship or mentorship, consistent group meetings with people their own age, an accountability partner, or just a friend who shares similar beliefs and values. In an era …

Radiobiology & Radiation Benefits In Alzheimer’S From Ct: A Physics Assessment, Lin Mousa, Guito Charles, Subhendra N. Sarkar

Publications and Research

This work is a review and assessment of research literature on Alzheimer’s disease (AD) today which is an irreversible neurological disorder, that continuously decreases the individual’s memory and thinking skills and, suddenly, the ability to carry out the simplest functions of daily living. Although treatment can only help manage the symptoms of AD, there is no cure for the disease. CT imaging is proven to be somewhat helpful in the detection of AD disease similar to MRI, multiple repeat CT seems to show promise in part-reversing the loss (radiation Hormesis). Invivo exposure, spatial distribution, and quantitative characterization could be essential …

The Living Breakwaters Pdr Efforts Econcrete Resource Analysis, Guianina Ferrari, Shervon Stephens, Calvin O. Walters Jr.

Publications and Research

On October 29, 2012, Superstorm Sandy impacted 443,000 people and caused nearly $19 billion (about $58 per person in the US) worth of damage within New York City. As part of the New York City infrastructure reparation plan, the Living Breakwaters project in Tottenville addressed coastal resilience, allocating $100M of public funds to a series of artificial breakwaters by the southwest coast of Staten Island. Each breakwater is constructed and designed to mitigate water flow in storm events. ECOncrete, a primary element of the breakwater, is a specialty cast cementitious product that is marine organism-friendly that encourages biocalcification and photosynthesis. …

Factors Modulating 99mtc-Maa Planar Lung Dosimetry For 90y Radioembolization, Benjamin P Lopez, Armeen Mahvash, James P Long, Marnix G E H Lam, S Cheenu Kappadath

Faculty, Staff and Student Publications

Purpose: To investigate the accuracy and biases of predicted lung shunt fraction (LSF) and lung dose (LD) calculations via 99m Tc-macro-aggregated albumin (99m Tc-MAA) planar imaging for treatment planning of 90 Y-microsphere radioembolization.

Methods and materials: LSFs in 52 planning and LDs in 44 treatment procedures were retrospectively calculated, in consecutive radioembolization patients over a 2 year interval, using 99m Tc-MAA planar and SPECT/CT imaging. For each procedure, multiple planar LSFs and LDs were calculated using different: (1) contours, (2) views, (3) liver 99m Tc-MAA shine-through compensations, and (4) lung mass estimations. The accuracy of each planar-based LSF and LD …

Utility Of Measurable Residual Disease For Predicting Treatment Outcomes With Bcr- And Bcl2-Targeted Therapies In Patients With Cll, William G Wierda, Thomas J Kipps, Othman Al-Sawaf, Brenda Chyla, Juliana M L Biondo, Yong Mun, Yanwen Jiang, John F Seymour

Faculty, Staff and Student Publications

Inhibitors targeting B-cell receptor (BCR) signaling pathway proteins and B-cell lymphoma-2 (BCL2) in chronic lymphocytic leukemia (CLL) are recommended in the first-line and relapsed/refractory disease settings. Measurable residual disease (MRD) is an important prognostic tool in patients treated with the BCL2-targeted agent, venetoclax. We explored the relationship between MRD status and progression-free (PFS)/overall survival (OS) in patients with CLL, following treatment with novel BCR- and BCL2-targeted agents. Compared with chemoimmunotherapy, higher rates of undetectable (u)MRD were achieved with BCL2-targeted therapies; achieving uMRD status was associated with longer PFS and OS than MRD-positivity. Continuous treatment with BCR-targeted agents did not achieve …

Identity-Related Experiences Of Asian American Trainees In Gynecologic Oncology, Jhalak Dholakia, Yeon Woo Lee, Karen H Lu, Warner K Huh, S Diane Yamada, Katherine C Fuh, Amanika S Kumar, Margaret I Liang, Navya Nair, Kenneth H Kim

Faculty, Staff and Student Publications

Background: Anti-Asian violence increased during the COVID-19 pandemic. Asian American/Pacific Islanders (AAPI) represent a diverse population experiencing a long history of stereotyping and exclusionism; however, this group is often left out of diversity/inclusion conversations. In academic medicine, AAPI are under-represented in leadership. We characterized the personal/professional experiences of AAPI gynecologic oncology trainees and assessed the impact of a virtual panel discussion with leaders in the field.

Methods: An anonymous survey was disseminated online to trainees in/interested in gynecologic oncology fellowship who identified as AAPI, using modified snowball sampling. A virtual session with AAPI leaders in gynecologic oncology discussed themes emerging …

Learning From Manipulable Signals, Mehmet Ekmekci, Leandrro Gorno, Lucas Maestri, Jian Sun, Dong Wei

Research Collection Lee Kong Chian School Of Business

We study a dynamic stopping game between a principal and an agent. The agent is privately informed about his type. The principal learns about the agent’s type from a noisy performance measure, which can be manipulated by the agent via a costly and hidden action. We fully characterize the unique Markov equilibrium of this game. We find that terminations/ market crashes are often preceded by a spike in (expected) performance. Our model also predicts that, due to endogenous signal manipulation, too much transparency can inhibit learning. As the players get arbitrarily patient, the principal elicits no useful information from the …

Governance And Design Of Digital Platforms: A Review And Future Research Directions On A Meta-Organization, Liang Chen, Tony W. Tong, Shaoqin Tang, Nianchen Han

Research Collection Lee Kong Chian School Of Business

The burgeoning digital-platforms literature across multiple business disciplines has primarily characterized the platform as a market or network. Although the organizing role of platform owners is well recognized, the literature lacks a coherent approach to understanding organizational governance in the platform context. Drawing on classic organizational governance theories, this paper views digital platforms as a distinct organizational form where the mechanisms of incentive and control routinely take center stage. We systematically review research on digital platforms, categorize specific governance mechanisms related to incentive and control, and map a multitude of idiosyncratic design features studied in prior research onto these mechanisms. …

Covid-19 Mitigation Strategies: A Natural Experiment Highlighting The Importance Of Structure In The Prevention And Treatment Of Childhood Obesity, Keith Brazendale, Michael Beets, Robert Weaver Med, Phd, Bridget Armstrong, Ethan T. Hunt

Faculty Publications

Societal restrictions due to the Coronavirus Disease 2019 (COVID-19), such as the closure of schools, childcare centers, and community programs, were implemented to prevent the spread of the disease and to protect the health and well-being of the population. These mitigation efforts drastically interrupted the day-to-day environments of children and adolescents and influenced how they spent the majority of their waking hours. Evidence shows on days when children and adolescents are in “structured” settings, such as school or other extracurricular programs or day camps, their obesogenic behaviors (i.e., sleep, physical activity, diet, and screen/media time) are more favorable than on …

Study Of The Roles Of Cytochrome P450 (Cyps) In The Metabolism And Cytotoxicity Of Perhexiline, Zhen Ren, Si Chen, Xuan Qin, Feng Li, Lei Guo

Faculty, Staff and Students Publications

Perhexiline is a prophylactic antianginal agent developed in the 1970s. Although, therapeutically, it remained a success, the concerns of its severe adverse effects including hepatotoxicity caused the restricted use of the drug, and eventually its withdrawal from the market in multiple countries. In the clinical setting, cytochrome P450 (CYP) 2D6 is considered as a possible risk factor for the adverse effects of perhexiline. However, the role of CYP-mediated metabolism in the toxicity of perhexiline, particularly in the intact cells, remains unclear. Using our previously established HepG2 cell lines that individually express 14 CYPs (1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, …

Wellness And Coping Of Physicians Who Worked In Icus During The Pandemic: A Multicenter Cross-Sectional North American Survey, Karen E. A. Burns, Rachel K. Mcdonald, Et Al.

2020-Current year OA Pubs

OBJECTIVES: Few surveys have focused on physician moral distress, burnout, and professional fulfilment. We assessed physician wellness and coping during the COVID-19 pandemic.

DESIGN: Cross-sectional survey using four validated instruments.

SETTING: Sixty-two sites in Canada and the United States.

SUBJECTS: Attending physicians (adult, pediatric; intensivist, nonintensivist) who worked in North American ICUs.

INTERVENTION: None.

MEASUREMENTS AND MAIN RESULTS: We analysed 431 questionnaires (43.3% response rate) from 25 states and eight provinces. Respondents were predominantly male (229 [55.6%]) and in practice for 11.8 ± 9.8 years. Compared with prepandemic, respondents reported significant intrapandemic increases in days worked/mo, ICU bed occupancy, and …

Ten Simple Rules And A Template For Creating Workflows-As-Applications, Michael J. Roach, N. Tessa Pierce-Ward, Radoslaw Suchecki, Vijini Mallawaarachchi, Bhavya Papudeshi, Scott A. Handley, C. Titus Brown, Nathan S. Watson-Haigh, Robert A. Edwards

2020-Current year OA Pubs

No abstract provided.

Proteasome Inhibitors Silence Oncogenes In Multiple Myeloma Through Localized Histone Deacetylase 3 (Hdac3) Stabilization And Chromatin Condensation, Laure Maneix, Polina Iakova, Shannon E Moree, Joanne I Hsu, Ragini M Mistry, Fabio Stossi, Premal Lulla, Zheng Sun, Ergun Sahin, Sarvari V Yellapragada, André Catic

Faculty, Staff and Students Publications

Proteasome inhibitors have become the standard of care for multiple myeloma (MM). Blocking protein degradation particularly perturbs the homeostasis of short-lived polypeptides such as transcription factors and epigenetic regulators. To determine how proteasome inhibitors directly impact gene regulation, we performed an integrative genomics study in MM cells. We discovered that proteasome inhibitors reduce the turnover of DNA-associated proteins and repress genes necessary for proliferation through epigenetic silencing. Specifically, proteasome inhibition results in the localized accumulation of histone deacetylase 3 (HDAC3) at defined genomic sites, which reduces H3K27 acetylation and increases chromatin condensation. The loss of active chromatin at super-enhancers critical …

Dawn-To-Dusk Dry Fasting Induces Anti-Atherosclerotic, Anti-Inflammatory, And Anti-Tumorigenic Proteome In Peripheral Blood Mononuclear Cells In Subjects With Metabolic Syndrome, Ayse L Mindikoglu, Jihwan Park, Antone R Opekun, Mustafa M Abdulsada, Zoe R Wilhelm, Prasun K Jalal, Sridevi Devaraj, Sung Yun Jung

Faculty, Staff and Students Publications

BACKGROUND: Metabolic syndrome characterized by abdominal obesity, high blood pressure, elevated fasting glucose and triglyceride levels and low high-density lipoprotein cholesterol level is associated with pro-inflammatory state, increased risk for atherosclerosis, and multiple cancers. Our previous results on subjects with metabolic syndrome showed that 4-week dawn-to-dusk (sunset) dry fasting resulted in significant changes in the serum proteome and improvement in several metabolic risk factors. Peripheral blood mononuclear cells (PBMC) proteomics is a powerful tool that can provide mechanistic insights into how dawn-to-dusk dry fasting affects protein expression in metabolic pathways at cellular level. In this study, we determined whether dawn-to-dusk …

A New Chapter In An Evolving Pandemic: Successful Pediatric Liver Transplantation With Sars-Cov-2+ Donors, Matthew Benjamin Goss, Daniel Hao Bin Leung, Stephanie Marie Pouch, Flor M Munoz, Elizabeth Andrea Moulton, Tyler Malcolm Mccann Lambing, Sarah Koohmaraie, Nicolas Fernando Moreno, Christine A O'Mahony, John A Goss, Nhu Thao Nguyen Galván

Faculty, Staff and Students Publications

BACKGROUND: Amid a viral pandemic with poorly understood transmissibility and pathogenicity in the pediatric patient, we report the first pediatric liver transplants utilizing allografts from SARS-CoV-2+ donors.

METHODS: We describe the outcomes of two pediatric liver transplant recipients who received organs from SARS-CoV-2 nucleic acid test-positive (NAT+) donors. Data were obtained through the respective electronic medical record system and UNet DonorNet platform.

RESULTS: The first donor was a 3-year-old boy succumbing to head trauma. One of four nasopharyngeal (NP) swabs and 1 of 3 bronchoalveolar lavage (BAL) NAT tests demonstrated SARS-CoV-2 infection before organ procurement. The second donor was a …