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2022

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Kasalukuyang Pagtuturo Ng Wikang Filipino At Pananaliksik Ng Pilipinas Sa Tsina, Yi Huang Dec 2022

Kasalukuyang Pagtuturo Ng Wikang Filipino At Pananaliksik Ng Pilipinas Sa Tsina, Yi Huang

Katipunan

Sa mga nagdaang taon, ang domestikong pangangailangan para sa pagsasanay sa talento ng pagsasalita ng Filipino pati na ang pag-aaral nito ay sumisikat. At ang iba’t ibang kagawaran, negosyo, at institusyon ay may agarang pangangailangan para sa nasabing mga talento. Ang Peking University ang unang unibersidad sa Tsina na nagturo ng wikang ito. Sa ilalim ng pamumuno ng nasabing unibersidad, ang mga programa ukol sa wika at kultura ng Pilipinas ay umusbong sa Tsina. Ang ganitong modelo ng propesyonal na konstruksiyon at ang pag-unlad na nag-uugnay sa mga domestikong unibersidad ay nagdala ng bagong sigla sa mga pananaliksik ukol sa …


Gunita Bilang Pandaigdigang Kamalayan Ng Nagpapatuloy Na Kasaysayan Sa Global Na Lipunan: Pagturing Sa Eksibisyong Gintong Liwayway: Sining Ng Progresibong Pagbabago, Gian Carlo Delgado Dec 2022

Gunita Bilang Pandaigdigang Kamalayan Ng Nagpapatuloy Na Kasaysayan Sa Global Na Lipunan: Pagturing Sa Eksibisyong Gintong Liwayway: Sining Ng Progresibong Pagbabago, Gian Carlo Delgado

Katipunan

Layon ng papel na ito na suriin ang mga sining na naglalahad ng mga konsepto ng gunita sa eksibisyong Gintong Liwayway: Sining ng Progresibong Pagbabago ng UP Artists’ Circle Fraternity, na ginanap sa Anima Art Space. Ang mga konseptong ito ng gunita ay itinuturing na kaakibat ng pagsasapantaha ng pagbabago na ipinaparating sa paglikha ng isang imagined world. Ang imagined world ay kinikilala bilang isang pandaigdigang kamalayan na nakaugnay sa Social Realism, na isang masining na paraan ng pagpapahayag ng paghihimagsik. Tinuturol ng pagturing na ito sa eksibisyon ang konsepto ng gunita bilang aspekto ng buhay at impluwensiya ng mga …


"The Next 10 Years": Keynote Address On The 10th Anniversary Of The Federation Of Asian Canadian Lawyers, Carol Liao Dec 2022

"The Next 10 Years": Keynote Address On The 10th Anniversary Of The Federation Of Asian Canadian Lawyers, Carol Liao

UBC Law Review

No abstract provided.


Refugee-Background Students In New Zealand And The United States: Roots And Results Of Educational Policies And Practices, Jody L. Mcbrien, Maria Hayward Dec 2022

Refugee-Background Students In New Zealand And The United States: Roots And Results Of Educational Policies And Practices, Jody L. Mcbrien, Maria Hayward

Journal of Global Education and Research

Both the United States (US) and New Zealand (NZ) have been resettling refugees since the Second World War. As such, and because of several international treaties signed by both countries, they must concern themselves with the education of resettled refugee students in their nations. In this study, the researchers examine the international agreements and national resettlement policies that shape these nations’ refugee education policies. Second, educational practices for refugee students in the US and NZ using phenomenological qualitative research based on observations, interviews, and focus groups with teachers and refugee students are examined. The researchers conclude that the more systematic …


What Place For Jus Cogens? How Manfred Lachs Foresaw New Thinking In International Space Law, Laura Jamschon Mac Garry, Steven Freeland Dec 2022

What Place For Jus Cogens? How Manfred Lachs Foresaw New Thinking In International Space Law, Laura Jamschon Mac Garry, Steven Freeland

Journal of Space Law

No abstract provided.


The Next Arms Race And The Unknown Frontier Of Outer Space: The Conceptual Challenges For International Law And Space Weaponization, Rebecca Connolly, Aine Bennett Dec 2022

The Next Arms Race And The Unknown Frontier Of Outer Space: The Conceptual Challenges For International Law And Space Weaponization, Rebecca Connolly, Aine Bennett

Journal of Space Law

No abstract provided.


Space Arbitration And Harmful Interference Disputes, Laura Yvonne Zielinski Dec 2022

Space Arbitration And Harmful Interference Disputes, Laura Yvonne Zielinski

Journal of Space Law

No abstract provided.


The Development Of Labor Law In Outer Space: A Comparison With The American Frontier And The High Seas, Connor Hogan Dec 2022

The Development Of Labor Law In Outer Space: A Comparison With The American Frontier And The High Seas, Connor Hogan

Journal of Space Law

No abstract provided.


Avoiding Conflict In Asteroid Resource Extraction, Gregory Radisic, Connor Haffey Dec 2022

Avoiding Conflict In Asteroid Resource Extraction, Gregory Radisic, Connor Haffey

Journal of Space Law

No abstract provided.


The Invisible Meat Microcosmos: Investigations Of Processed Meats' Specific Spoilage Organisms, Rebecca Furbeck Dec 2022

The Invisible Meat Microcosmos: Investigations Of Processed Meats' Specific Spoilage Organisms, Rebecca Furbeck

Department of Animal Science: Dissertations, Theses, and Student Research

As humankind grows in population, so will our need to compete against bacterial populations which spoil foodstuffs before we are able to consume them. This dissertation aims to identify the bacterial communities responsible for meat spoilage, and the mechanisms that govern the behaviors of these organisms. The literature review summarizes the state of knowledge regarding factors that influence meat microbiome composition, and how analytical methods can influence research outcomes. Study 1 aimed to identify the impact of additional ingredients and processing steps on the microbial ecology of processed turkey products. The main specific spoilage organisms (SSOs) belonged to the orders …


Communication As Conscience, Florence Chee Dec 2022

Communication As Conscience, Florence Chee

School of Communication: Faculty Publications and Other Works

Focusing on ethics in games studies, Chee notes the importance of
communication as it has played parts in these other fields and how that might
reflect back on our community.


Internal And External Validation Of An Alcohol Biomarker For Screening In Trauma, Majid Afshar, Kenneth Baker, Josefine Corral, Erin Ross, Erin Lowery, Richard Gonzalez, Ellen L. Burnham, Rachael A. Callcut, Lucy Z. Kornblith, Carolyn Hendrickson, Elizabeth J. Kovacs, Cara Joyce Dec 2022

Internal And External Validation Of An Alcohol Biomarker For Screening In Trauma, Majid Afshar, Kenneth Baker, Josefine Corral, Erin Ross, Erin Lowery, Richard Gonzalez, Ellen L. Burnham, Rachael A. Callcut, Lucy Z. Kornblith, Carolyn Hendrickson, Elizabeth J. Kovacs, Cara Joyce

Biostatistics Collaborative Core: Faculty Publications and Other Works

Objective: We aimed to examine biomarkers for screening unhealthy alcohol use in the trauma setting.

Summary and Background Data: Self-report tools are the practice standard for screening unhealthy alcohol use; however, their collection suffers from recall bias and incomplete collection by staff.

Methods: We performed a multi-center prospective clinical study of 251 adult patients who arrived within 24 hours of injury with external validation in another 60 patients. The Alcohol Use Disorders Identification Test served as the reference standard. The following biomarkers were measured: (1) PEth; (2) ethyl glucuronide; (3) ethyl sulfate; (4) gammaglutamyl-transpeptidase; (5) carbohydrate deficient transferrin; and (6) …


Students' Perceptions Of Online Equine Courses And Their Impacts On Learning Outcomes, Blaire L. (Gibbens) Speck Dec 2022

Students' Perceptions Of Online Equine Courses And Their Impacts On Learning Outcomes, Blaire L. (Gibbens) Speck

Department of Animal Science: Dissertations, Theses, and Student Research

Post-secondary education is always changing and evolving. Over the last few years, significant changes in education have resulted in an increased number of online courses. Approximately 28% of students seeking higher education participate in at least one online course and 14% are enrolled exclusively in distance or online programs (Allen & Seaman, 2016). However, courses that are typically hands-on, like equine science, may be more challenging online. The hands-on experiences in equine science classes help prepare students for future careers. Due to an increase in students choosing to take courses online, a review of online teaching methods was conducted to …


Recent Advances To Overcome Methane Hydrate Formation Challenges Using Nanostructure Promoters: A Mini Review Towards Industrialization, Mohsen Hosseini Dec 2022

Recent Advances To Overcome Methane Hydrate Formation Challenges Using Nanostructure Promoters: A Mini Review Towards Industrialization, Mohsen Hosseini

Journal of Applied Sciences and Nanotechnology

Natural gas has recently drawn considerable attention due to its low emissions upon combustion. Pipeline transmission of natural gas is costly and always encounters different obstacles. Therefore, an effective industrial alternative for the storage and transmission of natural gas is needed. Hydrates, also known as solidified natural gas, have been proven to be a more feasible replacement compared to pipeline transmission, CNG, or LNG. Scientists have introduced promoters to shorten the induction time, increase the storage capacity, and improve the stability of hydrates. Nanostructure materials have demonstrated promising promotion results, suggesting a bright future and a critical step in the …


Low-Income Housing Tax Credit And The Role Of Public Participation, Juan Antonio Sorto Dec 2022

Low-Income Housing Tax Credit And The Role Of Public Participation, Juan Antonio Sorto

Dissertations (2016-Present)

This dissertation analyzes the role of public participation and the implementation of Low-Income Housing Tax Credit (LIHTC) funded developments in higher socio-economic communities. Using archival research, participant observation, and in-depth interviews, the dissertation examines the placement of North Court Villas, Frisco, Texas and 2640 Fountain View, Houston, Texas. The literature shows that the placement of LIHTC-funded developments continues to be distributed in low-income communities. Housing policies have not been able to resolve these imbalances, which has resulted in multiple court interventions. However, court rulings have not sufficiently addressed the aspects of public participation of these developments. Research shows that these …


Towards The Electronic Response Of Carbon-Based Van Der Waals Heterostructures In A Diamond Anvil Cell, George Thomas Foskaris Dec 2022

Towards The Electronic Response Of Carbon-Based Van Der Waals Heterostructures In A Diamond Anvil Cell, George Thomas Foskaris

UNLV Theses, Dissertations, Professional Papers, and Capstones

The nanoscale regime of materials has been at the forefront of research and interest in condensed matter physics for many years. In a merger of the fields of two-dimensional (2D) materials and high pressure physics, we present an investigation of the electronic response of carbon-based, van der Waals (vdW) heterostructures in a diamond anvil cell (DAC). Combining these fields presents us with the ability to study the characteristics of such systems both optically, and through electrical transport. Properties such as conductance, band structure, and layer number are considered. The samples in this study are assembled using exfoliation and stacking techniques …


How Medical Students Use Social Support To Cope With Burnout: A Grounded Theory Approah, Michelle Nicole I. Janeo Dec 2022

How Medical Students Use Social Support To Cope With Burnout: A Grounded Theory Approah, Michelle Nicole I. Janeo

UNLV Theses, Dissertations, Professional Papers, and Capstones

Medical education to become a physician is a rigorous training process resulting in high rates of burnout in medical students. Research on burnout in human service providers results in negative impacts on professionalism, well-being, and the future healthcare workforce. Previous research investigating strategies to combat burnout has demonstrated that resilience is a dominant explanation for recovery from burnout. There is limited data exploring how social support is used by medical students as a resource to cope with the demands of training. Considering that social support is one primary factor that contributes to resilience, it is important to understand the process …


Evaluating Post-Training Engagement, Alyssa B. Trinity, Caitlyn D. Gonzalez Dec 2022

Evaluating Post-Training Engagement, Alyssa B. Trinity, Caitlyn D. Gonzalez

Capstone Projects and Master's Theses

Impact Launch (IL) is a collective of social impact professionals dedicated to creating sustainable and equitable change. IL provides strategic planning, project design, collaborative capacity building, coaching, and leadership intensives. Similar to those who’ve undergone other training programs, alumni of IL’s leadership training are prone to becoming disengaged with the tools and stagnant in their learning. The purpose of this project was to begin efforts to increase alumni engagement with the tools and each other through conducting a series of interviews. Six alumni were interviewed to collect feedback on how IL can better support engagement. The major expected outcome for …


Transition From Homeless To Homed, Heidy Avalos Dec 2022

Transition From Homeless To Homed, Heidy Avalos

Capstone Projects and Master's Theses

Interim Inc focuses on providing permanent supportive housing for adults with psychiatric disabilities and dealing with homelessness. The waitlist for Interim’s properties are extremely long leaving people on the waitlist still homeless. The purpose of the project is to provide informational pamphlets to residents and to people on the waitlist. There are two different pamphlets. One is for residents that need the support in clarification of the programs that Interim offers since there is still confusion among residents. The other pamphlet is full of resources that people can access while still finding themselves homeless. The expected outcome is for both …


Branding For Hope Services, Roberta Garcia Dec 2022

Branding For Hope Services, Roberta Garcia

Capstone Projects and Master's Theses

Hope Services is a 501(C)(3) nonprofit organization located in Seaside, California. Hope Services was in need of a new marketing and branding plan in order to reach more people throughout the various communities that are being served. The first contributing factor is limited outreach throughout the community, the consequence to that is low client rates which brings less staff. The second contributing factor is limited caseworkers, the consequence is low levels of applications being accepted or seen. The last contributing factor is limited access to technology, the consequence is low levels of knowledge of resources for possible clients. The capstone …


The Grizzly, December 1, 2022, Layla Halterman, Sean Mcginley, Liam Reilly, Jenna Smith, Ava Compagnoni, Marie Sykes, Jack Hauler, Michael Delaney, Sabrina Mcgettigan, Heidi Jensen, Rachel Brown, Simra Mariam, Erin Corcoran, Kate Horan, Isabella Villegas Dec 2022

The Grizzly, December 1, 2022, Layla Halterman, Sean Mcginley, Liam Reilly, Jenna Smith, Ava Compagnoni, Marie Sykes, Jack Hauler, Michael Delaney, Sabrina Mcgettigan, Heidi Jensen, Rachel Brown, Simra Mariam, Erin Corcoran, Kate Horan, Isabella Villegas

Ursinus College Grizzly Newspaper, 1978 to Present

1000th Edition: A Brief Look at Past Eras of The Grizzly • How Important Are Our Archives? • Comments From Grizzly Alumni • Long-Running Professors • Grizzlies of Years Past • Opinions: Silly but Necessary - The Ranking of Stalls in the Myrin Women's Bathroom • Check Out This Sports Column From the 90s Grizzly! • Congrats to the Football Team on Winning Their Game in the Centennial-MAC Bowl Conference Series! • The Mascot Evolution


Anxiety Disorders In Children And Adolescents, Alicia Kowalchuk, Sandra J Gonzalez, Roger J Zoorob Dec 2022

Anxiety Disorders In Children And Adolescents, Alicia Kowalchuk, Sandra J Gonzalez, Roger J Zoorob

Faculty, Staff and Students Publications

Anxiety disorders are the most common psychiatric conditions in children and adolescents, affecting nearly 1 in 12 children and 1 in 4 adolescents. Anxiety disorders include specific phobias, social anxiety disorder, separation anxiety disorder, agoraphobia, panic disorder, and generalized anxiety disorder. Risk factors include parental history of anxiety disorders, socioeconomic stressors, exposure to violence, and trauma. The U.S. Preventive Services Task Force recommends screening for anxiety disorders in children eight years and older; there is insufficient evidence to support screening in children younger than eight years. Symptoms of anxiety disorders in children and adolescents are similar to those in adults …


Direct Cd32 T-Cell Cytotoxicity: Implications For Breast Cancer Prognosis And Treatment, Giuseppe Sconocchia, Giulia Lanzilli, Valeriana Cesarini, Domenico A Silvestris, Katayoun Rezvani, Roberto Arriga, Sara Caratelli, Ken Chen, Jinzhuang Dou, Carlo Cenciarelli, Gabriele Toietta, Silvia Baldari, Tommaso Sconocchia, Francesca De Paolis, Anna Aureli, Giandomenica Iezzi, Maria Irno Consalvo, Francesco Buccisano, Maria I Del Principe, Luca Maurillo, Adriano Venditti, Alessio Ottaviani, Giulio C Spagnoli Dec 2022

Direct Cd32 T-Cell Cytotoxicity: Implications For Breast Cancer Prognosis And Treatment, Giuseppe Sconocchia, Giulia Lanzilli, Valeriana Cesarini, Domenico A Silvestris, Katayoun Rezvani, Roberto Arriga, Sara Caratelli, Ken Chen, Jinzhuang Dou, Carlo Cenciarelli, Gabriele Toietta, Silvia Baldari, Tommaso Sconocchia, Francesca De Paolis, Anna Aureli, Giandomenica Iezzi, Maria Irno Consalvo, Francesco Buccisano, Maria I Del Principe, Luca Maurillo, Adriano Venditti, Alessio Ottaviani, Giulio C Spagnoli

Faculty, Staff and Student Publications

The FcγRII (CD32) ligands are IgFc fragments and pentraxins. The existence of additional ligands is unknown. We engineered T cells with human chimeric receptors resulting from the fusion between CD32 extracellular portion and transmembrane CD8α linked to CD28/ζ chain intracellular moiety (CD32-CR). Transduced T cells recognized three breast cancer (BC) and one colon cancer cell line among 15 tested in the absence of targeting antibodies. Sensitive BC cell conjugation with CD32-CR T cells induced CD32 polarization and down-regulation, CD107a release, mutual elimination, and proinflammatory cytokine production unaffected by human IgGs but enhanced by cetuximab. CD32-CR T cells protected immunodeficient mice …


Pet/Mr Imaging Of A Lung Metastasis Model Of Clear Cell Renal Cell Carcinoma With (2s,4r)-4-[18f]Fluoroglutamine, Alyssa C Pollard, Vincenzo Paolillo, Bhasker Radaram, Sarah Qureshy, Li Li, Tapati Maity, Lei Wang, Md Nasir Uddin, Christopher G Wood, Jose A Karam, Mark D Pagel, David Piwnica-Worms, Steven W Millward, Natalie Wall Fowlkes, William Norton, Brian J Engel, Federica Pisaneschi, Niki M Zacharias Dec 2022

Pet/Mr Imaging Of A Lung Metastasis Model Of Clear Cell Renal Cell Carcinoma With (2s,4r)-4-[18f]Fluoroglutamine, Alyssa C Pollard, Vincenzo Paolillo, Bhasker Radaram, Sarah Qureshy, Li Li, Tapati Maity, Lei Wang, Md Nasir Uddin, Christopher G Wood, Jose A Karam, Mark D Pagel, David Piwnica-Worms, Steven W Millward, Natalie Wall Fowlkes, William Norton, Brian J Engel, Federica Pisaneschi, Niki M Zacharias

Faculty, Staff and Student Publications

Purpose: Metabolic reprogramming plays an important role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Currently, positron emission tomography (PET) reporters are not used clinically to visualize altered glutamine metabolism in ccRCC, which greatly hinders detection, staging, and real-time therapeutic assessment. We sought to determine if (2S,4R)-4-[18F]fluoroglutamine ([18F]FGln) could be used to interrogate altered glutamine metabolism in ccRCC lesions in the lung.

Procedures: We generated a novel ccRCC lung lesion model using the ccRCC cell line UMRC3 stably transfected with GFP and luciferase constructs. This cell line was used for characterization of [18F]FGln uptake and retention by transport …


Immunological Conversion Of Solid Tumours Using A Bispecific Nanobioconjugate For Cancer Immunotherapy, Yifei Lu, Kristin Huntoon, Daeyong Lee, Yifan Wang, Jonghoon Ha, Yaqing Qie, Xuefeng Li, Benjamin R Schrank, Shiyan Dong, Thomas D Gallup, Minjeong Kang, Hai Zhao, Yi An, Zhaogang Yang, Jing Li, Betty Y S Kim, Wen Jiang Dec 2022

Immunological Conversion Of Solid Tumours Using A Bispecific Nanobioconjugate For Cancer Immunotherapy, Yifei Lu, Kristin Huntoon, Daeyong Lee, Yifan Wang, Jonghoon Ha, Yaqing Qie, Xuefeng Li, Benjamin R Schrank, Shiyan Dong, Thomas D Gallup, Minjeong Kang, Hai Zhao, Yi An, Zhaogang Yang, Jing Li, Betty Y S Kim, Wen Jiang

Faculty, Staff and Student Publications

Solid tumours display a limited response to immunotherapies. By contrast, haematological malignancies exhibit significantly higher response rates to immunotherapies as compared with solid tumours. Among several microenvironmental and biological disparities, the differential expression of unique immune regulatory molecules contributes significantly to the interaction of blood cancer cells with immune cells. The self-ligand receptor of the signalling lymphocytic activation molecule family member 7 (SLAMF7), a molecule that is critical in promoting the body's innate immune cells to detect and engulf cancer cells, is expressed nearly exclusively on the cell surface of haematologic tumours, but not on solid ones. Here we show …


Engineered Exosomes Targeting Myc Reverse The Proneural-Mesenchymal Transition And Extend Survival Of Glioblastoma, Amanda R Haltom, Wafa E Hassen, Janine Hensel, Jiha Kim, Hikaru Sugimoto, Bingrui Li, Kathleen M Mcandrews, Meagan R Conner, Michelle L Kirtley, Xin Luo, Bingqing Xie, Olga V Volpert, Susan Olalekan, Natalia Maltsev, Anindita Basu, Valerie S Lebleu, Raghu Kalluri Dec 2022

Engineered Exosomes Targeting Myc Reverse The Proneural-Mesenchymal Transition And Extend Survival Of Glioblastoma, Amanda R Haltom, Wafa E Hassen, Janine Hensel, Jiha Kim, Hikaru Sugimoto, Bingrui Li, Kathleen M Mcandrews, Meagan R Conner, Michelle L Kirtley, Xin Luo, Bingqing Xie, Olga V Volpert, Susan Olalekan, Natalia Maltsev, Anindita Basu, Valerie S Lebleu, Raghu Kalluri

Faculty, Staff and Student Publications

Dysregulated Myc signaling is a key oncogenic pathway in glioblastoma multiforme (GBM). Yet, effective therapeutic targeting of Myc continues to be challenging. Here, we demonstrate that exosomes generated from human bone marrow mesenchymal stem cells (MSCs) engineered to encapsulate siRNAs targeting Myc (iExo-Myc) localize to orthotopic GBM tumors in mice. Treatment of late stage GBM tumors with iExo-Myc inhibits proliferation and angiogenesis, suppresses tumor growth, and extends survival. Transcriptional profiling of tumors reveals that the mesenchymal transition and estrogen receptor signaling pathways are impacted by Myc inhibition. Single nuclei RNA sequencing (snRNA-seq) shows that iExo-Myc treatment induces transcriptional repression of …


Low-Molecular-Weight Cyclin E Deregulates Dna Replication And Damage Repair To Promote Genomic Instability In Breast Cancer, Mi Li, Spiridon Tsavachidis, Fuchenchu Wang, Tuyen Bui, Tuyen Duong Thanh Nguyen, Linjie Luo, Asha S Multani, Melissa L Bondy, Kelly K Hunt, Khandan Keyomarsi Dec 2022

Low-Molecular-Weight Cyclin E Deregulates Dna Replication And Damage Repair To Promote Genomic Instability In Breast Cancer, Mi Li, Spiridon Tsavachidis, Fuchenchu Wang, Tuyen Bui, Tuyen Duong Thanh Nguyen, Linjie Luo, Asha S Multani, Melissa L Bondy, Kelly K Hunt, Khandan Keyomarsi

Faculty, Staff and Student Publications

Low-molecular-weight cyclin E (LMW-E) is an N-terminus deleted (40 amino acid) form of cyclin E detected in breast cancer, but not in normal cells or tissues. LMW-E overexpression predicts poor survival in breast cancer patients independent of tumor proliferation rate, but the oncogenic mechanism of LMW-E and its unique function(s) independent of full-length cyclin E (FL-cycE) remain unclear. In the current study, we found LMW-E was associated with genomic instability in early-stage breast tumors (n = 725) and promoted genomic instability in human mammary epithelial cells (hMECs). Mechanistically, FL-cycE overexpression inhibited the proliferation of hMECs by replication stress and DNA …


Heterogeneous Nuclear Ribonucleoprotein K Is Overexpressed In Acute Myeloid Leukemia And Causes Myeloproliferation In Mice Via Altered, Marisa J L Aitken, Prerna Malaney, Xiaorui Zhang, Shelley M Herbrich, Lauren Chan, Oscar Benitez, Ashley G Rodriguez, Huaxian Ma, Rodrigo Jacamo, Ruizhi Duan, Todd M Link, Steven M Kornblau, Rashmi Kanagal-Shamanna, Carlos E Bueso-Ramos, Sean M Post Dec 2022

Heterogeneous Nuclear Ribonucleoprotein K Is Overexpressed In Acute Myeloid Leukemia And Causes Myeloproliferation In Mice Via Altered, Marisa J L Aitken, Prerna Malaney, Xiaorui Zhang, Shelley M Herbrich, Lauren Chan, Oscar Benitez, Ashley G Rodriguez, Huaxian Ma, Rodrigo Jacamo, Ruizhi Duan, Todd M Link, Steven M Kornblau, Rashmi Kanagal-Shamanna, Carlos E Bueso-Ramos, Sean M Post

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) is driven by numerous molecular events that contribute to disease progression. Herein, we identify hnRNP K overexpression as a recurrent abnormality in AML that negatively correlates with patient survival. Overexpression of hnRNP K in murine fetal liver cells results in altered self-renewal and differentiation potential. Further, murine transplantation models reveal that hnRNP K overexpression results in myeloproliferation in vivo. Mechanistic studies expose a direct functional relationship between hnRNP K and RUNX1—a master transcriptional regulator of hematopoiesis often dysregulated in leukemia. Molecular analyses show that overexpression of hnRNP K results in an enrichment of an …


Small Molecule Targeting Nav17 Via Inhibition Of The Crmp2-Ubc9 Interaction Reduces Pain In Chronic Constriction Injury (Cci) Rats, Jiahe Li, Harrison J Stratton, Sabina A Lorca, Peter M Grace, Rajesh Khanna Dec 2022

Small Molecule Targeting Nav17 Via Inhibition Of The Crmp2-Ubc9 Interaction Reduces Pain In Chronic Constriction Injury (Cci) Rats, Jiahe Li, Harrison J Stratton, Sabina A Lorca, Peter M Grace, Rajesh Khanna

Faculty, Staff and Student Publications

The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target. However, targeting this channel directly has failed, and an indirect approach - disruption of interactions with accessory protein partners - has emerged as a viable alternative strategy. We recently reported that a small-molecule inhibitor of CRMP2 SUMOylation, compound


Chicago Alliance For Equity In Computer Science, Steven Mcgee, Lucia Dettori, Ronald I. Greenberg, Andrew M. Rasmussen, Dale F. Reed, Don Yanek Dec 2022

Chicago Alliance For Equity In Computer Science, Steven Mcgee, Lucia Dettori, Ronald I. Greenberg, Andrew M. Rasmussen, Dale F. Reed, Don Yanek

Computer Science: Faculty Publications and Other Works

Each year, about 14,000 Chicago Public Schools (CPS) students graduate with one year of high school computer science (CS) in fulfillment of the district’s CS graduation requirement. This accomplishment was the culmination of a decade of work by the Chicago Alliance for Equity in Computer Science (CAFÉCS), which includes CPS teachers and administrators, university CS faculty, and educational researchers. CAFÉCS research indicates that CPS significantly increased the capacity of schools to offer the Exploring Computer Science (ECS) introductory course, resulting in a rapid, equitable increase in students’ participation in CS. Making CS mandatory did not negatively impact performance in ECS. …