Digital Commons Network^™

How Do Digital Lives Affect Resident Mental Health In The Digital Era? Empirical Evidence Based On Chinese General Social Survey, Yan Chen, Mengyang Wei, Jaime Ortiz

Faculty, Staff and Students Publications

Having good mental health means we are better able to connect, function, cope and thrive. The widespread application of digital technology in daily life provides new ways and promising tools for residents to maintain their mental health. Given the importance of mental health for everyone, and the fact that mental health problems are prevalent worldwide, this study discusses how digital lives affects the mental health of residents. The results suggest that digital lives are significantly and positively associated with mental health. Mechanisms analysis identifies personal perceptions (self-rated physical exercise and subjective wellbeing) as the important paths for digital lives to …

Multiplex Hextuple Luciferase Assaying, Alejandro Sarrion-Perdigones, Yezabel Gonzalez, Lyra Chang, Tatiana Gallego-Flores, Damian W Young, Koen J T Venken

Faculty, Staff and Students Publications

We recently expanded the commonly used dual luciferase assaying method toward multiplex hextuple luciferase assaying, allowing monitoring the activity of five experimental pathways against one control at the same time. In doing so, while our expanded assay utilizes a total of six orthogonal luciferases instead of two, this assay, conveniently, still utilizes the well-established reagents and principles of the widely used dual luciferase assay. Three quenchable D-luciferin-consuming luciferases are measured after addition of D-Luciferin substrate, followed by quenching of their bioluminescence (BL) and the measurement of three coelenterazine (CTZ)-consuming luciferases after addition of CTZ substrate, all in the same vessel. …

Synthetic Assembly Dna Cloning Of Multiplex Hextuple Luciferase Reporter Plasmids, Alejandro Sarrion-Perdigones, Yezabel Gonzalez, Koen J T Venken

Faculty, Staff and Students Publications

Multiplex hextuple luciferase assaying allows monitoring the activity of five experimental pathways against one control at the same time. To perform multiplex hextuple luciferase assaying, six orthogonal luciferase reporter units are needed of which five are pathway-specific and one acts as a control for normalization. To ensure stoichiometric delivery of all six luciferase reporters in every transfected cell, synthetic assembly DNA cloning is used to stitch together all six luciferase reporter units into a single vector. Here, we provide a detailed three-step synthetic assembly DNA protocol to generate multiplex hextuple luciferase reporter plasmids for any five cellular signaling pathways of …

Pcsk9 Inhibitors In The Management Of Cardiovascular Risk: A Practical Guidance, Xiaoming Jia, Mahmoud Al Rifai, Anum Saeed, Christie M Ballantyne, Salim S Virani

Faculty, Staff and Students Publications

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are potent medications in the toolkit for treatment of atherosclerotic cardiovascular disease. These agents have been well studied in clinical trials supporting their efficacy in dramatically reducing low-density lipoprotein cholesterol (LDL-C) and impact on cardiovascular outcomes. Since the approval of commercial use for PCSK9 inhibitors in 2015, we have also gained significant experience in the use of these therapeutics in the real-world setting. In this article, we review current guideline recommendations, clinical trial evidence on efficacy and safety as well as data on cost-effectiveness, prescription and adherence. We focus primarily on the monoclonal …

The Barriers And Facilitators Of Hiv-Exposed Infant Testing As Perceived By Hiv-Positive Mothers In Botswana: A Qualitative Study, Grace Karugaba, Jennifer Simpson, Bathusi Mathuba, Onkemetse Phoi, Thato Regonamanye, Keofentse Mathuba, Eldah Dintwa, Bornapate Nkomo, Dinah Ramaabya, Mathabo Relebohile Pule, Mogomotsi Matshaba

Faculty, Staff and Students Publications

BACKGROUND: Despite high rates of HIV testing and enrolment of HIV-positive pregnant women on antiretroviral therapy in Botswana, coverage for HIV-exposed infant (HEI) testing remains suboptimal. Many factors can contribute to suboptimal HEI testing rates, but they have seldom been thoroughly investigated in Botswana. Therefore, the aim of this study was to explore the experiences and perspectives of HIV-positive mothers on the barriers and facilitators of HEI testing to inform interventions to promote HEI testing in Botswana.

METHODS: We conducted focus group discussions (FGDs) with HIV-positive mothers who gave birth in 2016 at the three largest public hospitals in Botswana. …

Catalyzing Remote Collaboration During The Covid-19 Pandemic And Beyond: Early Career Oceanographers Adopt Hybrid Open Science Framework, Johna E. Rudzin, Dax C. Soule, Justine Whitaker, Halle Berger, Sophie Clayton, Kristen E. Fogaren

OES Faculty Publications

The COVID-19 pandemic introduced many challenges for research scientists: reduction of lab and field observation collection and in-person meetings. These new constraints forced researchers to remote work and virtual networking, dramatically influencing scientific inquiry. Such challenges are compounded for those in early stages of their career, where data collection and networking are vital to be seen as productive. However, during this trying time of remote work, we, as a collective of early-career oceanographers, were actively developing and improving on an already-existent hybrid community of practice. Through our experiences, we believe this type of framework can enhance virtual collaboration to the …

Coastal Upwelling Enhances Abundance Of A Symbiotic Diazotroph (Ucyn-A) And Its Haptophyte Host In The Arctic Ocean, Corday R. Selden, Sveinn V. Einarsson, Kate E. Lowry, Katherine E. Crider, Robert S. Pickart, Peigen Lin, Carin J. Ashjian, P. Dreux Chappell

OES Faculty Publications

The apparently obligate symbiosis between the diazotroph Candidatus Atelocyanobacterium thalassa (UCYN-A) and its haptophyte host, Braarudosphaera bigelowii, has recently been found to fix dinitrogen (N²) in polar waters at rates (per cell) comparable to those observed in the tropical/subtropical oligotrophic ocean basins. This study presents the novel observation that this symbiosis increased in abundance during a wind-driven upwelling event along the Alaskan Beaufort shelfbreak. As upwelling relaxed, the relative abundance of B. bigelowii among eukaryotic phytoplankton increased most significantly in waters over the upper slope. As the host’s nitrogen demands are believed to be supplied primarily by UCYN-A, …

Cervical Cancer In Northern Tanzania–What Do Women Living With Hiv Know, Dorah Mrema, James Samwel Ngocho, Alex Mremi, Maryam Amour, Rogathe Machange, Benjamin C Shayo, Julius P Alloyce, Evaline Ndosi, Beatus T Shirima, Device Fande, Rahma Shehoza, Emmanuel Balandya, Bruno Sunguya, Stephen E Mshana, Alfred K Mteta, Eligius Lyamuya, John Bartlett, Blandina T Mmbaga

Faculty, Staff and Students Publications

BACKGROUND: Cervical cancer (CC) is more prevalent in women living with human immunodeficiency virus (HIV) infection compared to the general population. The magnitude is high among all countries burdened with HIV-Tanzania is no exception. Despite the unprecedented risk, women living with HIV (WLHIV) may not be aware of the risk and might have unfounded beliefs thereof. This study aimed to determine the knowledge, awareness, and beliefs on CC screening among WLHIV attending a clinic at the Kilimanjaro Christian Medical Centre (KCMC) in Northern Tanzania.

METHODS: This hospital-based cross-sectional study was conducted among 327 WLHIV attending care and treatment clinic (CTC) …

"It Just Kind Of Feels Like A Different World Now:" Stress And Resilience For Adolescents With Type 1 Diabetes In The Era Of Covid-19, Maeve B O'Donnell, Marisa E Hilliard, Viena T Cao, Miranda C Bradford, Krysta S Barton, Samantha Hurtado, Brenda Duran, Samantha Garcia Perez, Kiswa S Rahman, Samantha Scott, Faisal S Malik, Daniel J Desalvo, Catherine Pihoker, Chuan Zhou, Abby R Rosenberg, Joyce P Yi-Frazier

Faculty, Staff and Students Publications

PURPOSE: The COVID-19 pandemic has been a major stressor for adolescents. Given the unique implications of the pandemic for youth with type 1 diabetes (T1D), who already navigate multiple stressors as a function of their chronic condition, we aimed to describe the impact of the pandemic on adolescents with T1D and describe their coping strategies and resilience resources.

RESEARCH METHOD: In a 2-site (Seattle WA, Houston TX) clinical trial of a psychosocial intervention targeting stress/resilience, adolescents 13-18 years old with T1D ≥ 1 year and elevated diabetes distress were enrolled August 2020 - June 2021. Participants completed a baseline survey …

Rulemaking's Second Founding, Richard L. Marcus

Faculty Scholarship

No abstract provided.

Challenges With Defining Pharmaceutical Markets And Potential Remedies To Screen For Industry Consolidation, Robin Feldman, Brent D. Fulton, Jamie R. Godwin, Richard M. Scheffler

Faculty Scholarship

Context: Dramatic increases in pharmaceutical merger and acquisition (M&A) activity since 2010 suggest we are in the midst of a third wave of industry consolidation. Methods: The authors reviewed 168 economic, legal, medical, industry, and government sources to examine the effects of consolidation on competition and innovation and to explore how industry attributes complicate M&A regulation in a pharmaceutical context. Findings: The authors find that, in spite of certain metrics that might argue otherwise, con- solidation consistently reduces innovation and harms the public good. They also find that several factors within the pharmaceutical industry impede proper evaluation of proposed mergers. …

The New Racial Wage Code, Veena Dubal

Faculty Scholarship

The legal identity of on-demand platform workers has become a central site of conflict between labor and industry. Amidst growing economic inequality, labor representatives and workers have demanded that platform workers be afforded em­ ployee benefits and protections, including minimum wage and overtime rights. Plat­ form industrialists, meanwhile, have proffered a new regulatory category of worker­ neither employee nor independent contractor-that limits the protections available to the workforce, legalizes unpredictable, digitally-personalized piece-pay, and con­ stricts a worker's right to negotiate different terms. To date, legal and socio-legal scholars have primarily analyzed this third category of worker, codified by Proposi­ tion …

The Negotiable Implementation Of Environmental Law, Dave Owen

Faculty Scholarship

tional wisdom describes environmental law as a field filled with rigid mandates. ith that rigidity as a key premise, and they allege that inflexibility is a central failing or, alternatively, a squandered virtue. Influential reform proposals follow from both allegations. This Article demonstrates that these premises are often mistaken. Based on literature reviews and interviews with environmental-law practitioners, it shows that flexibility pervades environmental law, and regulators, regulated entities, and other interest groups routinely use negotiations to navigate that flexibility. Indeed, negotiation is so central to the field that one cannot understand environmental law, either in theory or practice, without …

Improving Knowledge And Self-Care Behaviors In Patients Diagnosed With Hypertension In The Primary Care Clinic Setting: A Quality Improvement Project, Leslie Chacko

Electronic Theses and Dissertations 2020 - Present

“Out of the 17 million global deaths per year that result from cardiovascular disease, 9.4 million are due to hypertension” (Zinat Motlagh et al., 2016). Hypertension is a chronic disease that has been a major public health concern, leading to further complications including stroke, cardiovascular, and kidney disease. The purpose of this QI project was to both better comprehend hypertension management in the primary care setting and improve patient self-care behaviors. The participants for this project were recruited from a list of patients selected after reviewing patient charts along with the community leader. Those patients who were previously diagnosed with …

The Effect Of Peer Support On Weight Loss In Young Adults, Astride Honore

Electronic Theses and Dissertations 2020 - Present

The current generation of youth may be the first in the United States who dies sooner than their parents and lives sicker. Stereotyping and discrimination may degrade communication between overweight/obese patients and their providers, exacerbating this negative trend. The purpose of this quality improvement project was to determine if participation in online support groups is an effective tool to assist obese young adults in weight management. Six participants followed a low-calorie diet (1500 cal/day for women and 1800 cal/day for men) and engaged in 30 minutes of daily exercise. All participants also filled out the Obesity and Weight Loss Quality …

Reducing Antibiotic Misuse For Sinusitis In A Pediatric Urgent Care, Delilah Rivera

Electronic Theses and Dissertations 2020 - Present

Antibiotic misuse has been linked to increased health care costs, potential adverse reactions, and antibiotic resistance (Weddle, 2017). The purpose of this DNP project is to examine if implementation of an Antibiotic Stewardship checklist and algorithm at two After Hours Pediatrics (AHP) urgent care clinics, would affect provider knowledge and prescribing practices in the management of sinusitis. Antibiotic stewardship is the effort to measure antibiotic prescribing, improve antibiotic prescribing by clinicians, minimize diagnoses, and ensure the correct antibiotics are selected when needed (Sanchez et al., 2021). The overall goal is to minimize unnecessary antibiotic prescriptions for sinusitis to reduce the …

The Center Cannot Hold: Zoom As A Potemkin Village, Hadar Aviram

Faculty Scholarship

No abstract provided.

Il-17 Producing Lymphocytes Cause Dry Eye And Corneal Disease With Aging In Rxrα Mutant Mouse, Jehan Alam, Ghasem Yazdanpanah, Rinki Ratnapriya, Nicholas Borcherding, Cintia S De Paiva, Dequan Li, Rodrigo Guimaraes De Souza, Zhiyuan Yu, Stephen C Pflugfelder

Faculty, Staff and Students Publications

PURPOSE: To investigate IL-17 related mechanisms for developing dry eye disease in the Pinkie mouse strain with a loss of function RXRα mutation.

METHODS: Measures of dry eye disease were assessed in the cornea and conjunctiva. Expression profiling was performed by single-cell RNA sequencing (scRNA-seq) to compare gene expression in conjunctival immune cells. Conjunctival immune cells were immunophenotyped by flow cytometry and confocal microscopy. The activity of RXRα ligand 9-cis retinoic acid (RA) was evaluated in cultured monocytes and γδ T cells.

RESULTS: Compared to wild type (WT) C57BL/6, Pinkie has increased signs of dry eye disease, including decreased tear …

New, Potent, Small Molecule Agonists Of Tyrosine Kinase Receptors Attenuate Dry Eye Disease, Zhiyuan Yu, Shaon Joy, Tianxiong Mi, Ghasem Yazdanpanah, Kevin Burgess, Cintia S De Paiva

Faculty, Staff and Students Publications

Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin3 (NT-3) bind to tyrosine kinase (Trk) receptors, TrkA, TrkB, and TrkC, respectively. This study investigated the efficacy of novel molecule agonists of Trk receptors in an in vivo model of dry eye disease (DED). Small molecule TrkC agonist (C1) and a pan-Trk agonist (pan) were synthesized for this. C57BL/6J mice were subjected to desiccating stress (DS) and received bilateral eye drops of C1, pan, or vehicle (2x/day). Dry eye signs, inflammation and expression of corneal barrier function, and conjunctival goblet cell (GC) densities were measured as part of the DED …

Non-Debt And Non-Bank Financing For Home Purchase: Promises And Risks, Shelby D. Green

Elisabeth Haub School of Law Faculty Publications

This Article explores the phenomenon of the NDNBs in home purchase and finance that has gained a growing presence in the mortgage marketplace since the 2008 crisis. Part II offers a deeper discussion of the risk-prone practices leading to the 2008 housing crisis and the regulatory and industry responses for recovery. Parts III and IV describe the emerging new models of home purchase. Part IV explores some of the apparent and hidden risks in these transactions. Part VI concludes with suggestions for assessing and managing risks and for reforms.

Loss Of H2r Signaling Disrupts Neutrophil Homeostasis And Promotes Inflammation-Associated Colonic Tumorigenesis In Mice, Zhongcheng Shi, Yuko Mori-Akiyama, Wa Du, Robert Fultz, Yanling Zhao, Wenly Ruan, Susan Venable, Melinda A Engevik, James Versalovic

Faculty, Staff and Students Publications

BACKGROUND & AIMS: We previously showed that histamine suppressed inflammation-associated colonic tumorigenesis through histamine type 2 receptor (H2R) signaling in mice. This study aimed to precisely elucidate the downstream effects of H2R activation in innate immune cells.

METHODS: Analyses using online databases of single-cell RNA sequencing of intestinal epithelial cells in mice and RNA sequencing of mouse immune cells were performed to determine the relative abundances of 4 histamine receptors among different cell types. Mouse neutrophils, which expressed greater amounts of H2R, were collected from the peritoneum of wild-type and H2R-deficient mice, of which low-density and high-density neutrophils were extracted …

Machine Learning Land Cover And Land Use Classification Of 4-Band Satellite Imagery, Lorelei Turner, Torrey J. Wagner, Paul Auclair, Brent T. Langhals

Faculty Publications

Land-cover and land-use classification generates categories of terrestrial features, such as water or trees, which can be used to track how land is used. This work applies classical, ensemble and neural network machine learning algorithms to a multispectral remote sensing dataset containing 405,000 28x28 pixel image patches in 4 electromagnetic frequency bands. For each algorithm, model metrics and prediction execution time were evaluated, resulting in two families of models; fast and precise. The prediction time for an 81,000-patch group of predictions wasmodels, and >5s for the precise models, and there was not a significant change in prediction time when a …

Prediction Of Formation Conditions Of Gas Hydrates Using Machine Learning And Genetic Programming, Anupama Kumari, Mukund Madhaw, Vishnu S. Pendyala

Faculty Research, Scholarly, and Creative Activity

The formation of gas hydrates in the pipelines of oil, gas, chemical, and other industries has been a significant problem for many years because the formation of gas hydrates may block the pipelines. Hence, the knowledge of the phase equilibrium conditions of gas hydrate became necessary for the economic and safe working of oil, gas, chemical industries. Various thermodynamic approaches with various mathematical techniques are available for the prediction of formation conditions of gas hydrates. In this chapter, the authors have discussed the least square support vector machine and artificial neural network models for the prediction of stability conditions of …

Membership Matters December-January 2022

Membership Matters

Membership Matters is produced by the Oregon Dental Association nine times a year. Issues include regular columns with regional news impacting the Oregon membership including clinical feature articles, regular editorial columns, government relations updates, association activities, member updates, component news, continuing education opportunities, and classifieds.

Membership Matters February 2022

Membership Matters

Membership Matters is produced by the Oregon Dental Association nine times a year. Issues include regular columns with regional news impacting the Oregon membership including clinical feature articles, regular editorial columns, government relations updates, association activities, member updates, component news, continuing education opportunities, and classifieds.

Membership Matters March 2022

Membership Matters

Membership Matters is produced by the Oregon Dental Association nine times a year. Issues include regular columns with regional news impacting the Oregon membership including clinical feature articles, regular editorial columns, government relations updates, association activities, member updates, component news, continuing education opportunities, and classifieds.

Membership Matters April 2022

Membership Matters

Membership Matters is produced by the Oregon Dental Association nine times a year. Issues include regular columns with regional news impacting the Oregon membership including clinical feature articles, regular editorial columns, government relations updates, association activities, member updates, component news, continuing education opportunities, and classifieds.

Membership Matters August 2022

Membership Matters

Membership Matters is produced by the Oregon Dental Association nine times a year. Issues include regular columns with regional news impacting the Oregon membership including clinical feature articles, regular editorial columns, government relations updates, association activities, member updates, component news, continuing education opportunities, and classifieds.

Membership Matters September 2022

Membership Matters

Membership Matters is produced by the Oregon Dental Association nine times a year. Issues include regular columns with regional news impacting the Oregon membership including clinical feature articles, regular editorial columns, government relations updates, association activities, member updates, component news, continuing education opportunities, and classifieds.

2022 Silicon Valley Pain Index, Scott Myers-Lipton, William Armaline

Faculty Research, Scholarly, and Creative Activity

No abstract provided.