Digital Commons Network^™

Proteasome Inhibitors Silence Oncogenes In Multiple Myeloma Through Localized Histone Deacetylase 3 (Hdac3) Stabilization And Chromatin Condensation, Laure Maneix, Polina Iakova, Shannon E Moree, Joanne I Hsu, Ragini M Mistry, Fabio Stossi, Premal Lulla, Zheng Sun, Ergun Sahin, Sarvari V Yellapragada, André Catic

Faculty, Staff and Students Publications

Proteasome inhibitors have become the standard of care for multiple myeloma (MM). Blocking protein degradation particularly perturbs the homeostasis of short-lived polypeptides such as transcription factors and epigenetic regulators. To determine how proteasome inhibitors directly impact gene regulation, we performed an integrative genomics study in MM cells. We discovered that proteasome inhibitors reduce the turnover of DNA-associated proteins and repress genes necessary for proliferation through epigenetic silencing. Specifically, proteasome inhibition results in the localized accumulation of histone deacetylase 3 (HDAC3) at defined genomic sites, which reduces H3K27 acetylation and increases chromatin condensation. The loss of active chromatin at super-enhancers critical …

Experiences Of Latinx Immigrant Parents Of Children With Developmental Disabilities In The Iep Process, Claudia Montoya, Carly Gilson, Valeria Yllades

Psychological Science Faculty Publications

Given the growing proportion of students receiving special education services who are culturally and linguistically diverse (CLD), there is a critical need to understand the experiences of Latinx immigrant parents of children with disabilities. This qualitative study sought to understand the perspectives of nine Latinx immigrant parents of children with developmental disabilities regarding their child's individualized education program (IEP). We conducted semi-structured interviews and analyzed the data using a general inductive approach and constant comparison analysis. Seven themes emerged: (a) parents' insecurity of knowledge, (b) difficult terminology , (c) confusion with the IEP process, (d) discrimination or misconceptions, (e) language …

Keynote Address: Alaska Native Peoples And The Environment, Elizabeth Saagulik Hensley, Esq.

Alaska Law Review

No abstract provided.

Heat Waves And A Public-Private Partnership In Alaska, Karen Sandrik, Sarah Matsumoto

Alaska Law Review

The recently-passed Inflation Reduction Act represents the largest single step that Congress has taken to combat harms from climate change. In its over $360 billion commitment, the Act incentivizes clean energy development and generation, includes methods to directly lower residential utility bills and increase home efficiency, promotes cleaner transportation and agricultural practices, and funds states' and cities' efforts to meet their individual climate goals. While many environmental organizations applauded the Act's passage, some—even simultaneously—expressed concern about its tradeoffs: the Act continues to invest in fossil fuels, subsidizing pipeline construction and guaranteeing new oil and gas leases, specifically expanding leasing in …

Coastal Marine Debris In Alaska: Problems Withplastics, Pollution, & Policy, Savannah Artusi

Alaska Law Review

Plastics pollute people and the planet throughout their lifecycle, from intensive extraction of raw materials to chemical leaching during their use to entangling animals in discarded plastic products. Plastic waste is especially troublesome in Alaska, where the state's extensive shoreline and coastal communities are disproportionately inundated with plastic marine debris. Current policies internationally, in the United States, and in Alaska have not done enough to prevent plastic waste from ending up on Alaska's coasts, to hold plastic producers accountable for that waste, or to provide Alaskan communities the support needed to remove the waste themselves. This Note offers several proposals …

The Kenai Rule In Four Acts: Bear Baiting, Firearms, And Hunting: Comment & Analysis Of Alaska V. Bernhardt, Jon C. Nachtigal, Mike Stocz

Alaska Law Review

The Kenai Rule, enacted by the U.S. Fish and Wildlife Service in 2016, prohibits (a) the hunting of brown bears with bait in the Kenai National Wildlife Refuge, (b) most hunting in the Skilak Wildlife Recreation Area, and (c) the discharge of firearms along the Kenai and Russian Rivers. The Kenai Rule was challenged by the State of Alaska and Safari Club International in Alaska v. Bernhardt. This Comment provides an overview of the case as it was heard in the District Court of Alaska. This discussion includes arguments and counterarguments surrounding the application of four legislative acts: the …

Voltage-Gated Potassium Channel Dependent Mechanisms Of Cardiovascular Adaptation To Chronic Exercise., Sean Raph

Electronic Theses and Dissertations

Exercise increases cardiac workload, escalating the demand for oxygen. The myocardial vasculature responds to the greater demand for oxygen by increasing blood flow to match the needs of the heart during augmented work. Increasing blood flow requires the coronary arteries dilate (a.k.a. vasodilation); this is mediated predominantly by vascular smooth muscle cell relaxation. Vasodilation is driven through inhibition of calcium influx into vascular smooth muscle cells. The prevention of calcium influx is largely mediated by efflux of potassium via potassium channels causing membrane hyperpolarization, which in turn closes voltage-dependent (or gated) calcium channels (VDCC). Changes in vascular smooth muscle cell …

Educational Experiences That Influence The Upward Mobility Of Maya Women In Belize, Jennine Pettit

Dissertations

This qualitative, multicase study explored the relationship between the educative experiences that allowed some Maya women in Belize to overcome economic and cultural barriers and change the trajectory of their lives. Many Maya girls face indigeneity, rurality, and gender discrimination (Vásquez, 2017), and obtaining a meaningful education was very difficult. The overall question for this study asked how exceptional Maya women perceived the relationship between their educational experiences and their ability to achieve advancement in society? This study also addressed the following sub-questions: How do Maya women describe their journey toward success? What institutional, cultural, or economic obstacles confront Maya …

The Effect Of Hurricane Harvey On The Continuity Of Patient Care For Long-Term Care Patients Diagnosed With Dementia In Dallas And Harris Counties, Texas, Martin Mufich

Dissertations

The purpose of this study was to analyze adverse health outcomes resulting from a disruption caused by Hurricane Harvey in the continuity of patient care for two geographically distinct patient populations: long-term care patients diagnosed with dementia in Dallas County, Texas and Harris County, Texas. Review of the literature revealed three themes: patient transitions from one level of care to another, members of the healthcare team (healthcare professionals, caregivers), and policies and strategies. The research design was a retrospective, quantitative, comparative, quasi-experimental design. The population of study consisted of long- term care patients diagnosed with dementia, N = 5,539. The …

Factors Influencing Political Self-Efficacy And Political Astuteness In Undergraduate Nurse Educators, Mark William Longshore

Dissertations

The profession of nursing, 3.9 million strong, continues to lag in taking an active role in the development of health policy. Reasons for that include lack of time, a lack of knowledge, and perceived competence of political action. The factors of knowledge and the related perceived competence, or in the case of this study, self-efficacy, could be improved through education. To that end, it was important to identify if nurse educators had the political astuteness, or knowledge, and self-efficacy. If not, how would nurses learn the necessary skills and gain confidence to be more active politically? The purpose of this …

Political Astuteness Of Nurse Educators, Gail Marie Hanson Brenner

Dissertations

Nurses comprise the largest segment of the healthcare workforce. Although nurses have advocated for patients since Florence Nightingale’s time, advocating for changes in health policies that affect populations on a larger scale has not changed over time (Rasheed et al., 2020). Professional nursing associations, nurse educators, and the Institute of Medicine have all identified the need to educate nurses in advocacy and health policy. With the recent revision of the American Association of Colleges of Nursing’s Essentials publication, health policy has moved from an essential to a featured concept that is found in the competencies and subcompetencies of the domains. …

Putting Policy Into Practice: The Problematisation Of Catalan Language Planning And Ideologies In Media Discourse, Farah Ali

Global Language Studies Faculty publications

The revitalization of the Catalan language has been an ongoing effort in Catalonia for decades. The language policies that have stemmed from this effort have perpetuated ideologies that promote the use and legitimization of Catalan as both an official and a vehicular language. While this effort is widely regarded as an example of successful language revitalization, the process has not been without conflict between Spanish and Catalan, particularly in terms of domains of use and disparate attitudes towards the two languages (Newman & Trenchs-Parera, 2015; Woolard, 2016; Soler & Gallego-Balsà, 2019; Ianos et al., 2020). Given that these policies aim …

Analysis Of Twitter User Covid-19 Vaccine Hesitancy: Cause And Solutions, Runze Song

Electronic Theses, Projects, and Dissertations

Reducing vaccine hesitancy is an essential public health & safety challenge worldwide, especially during the COVID - 19 pandemic. Governments and health safety agencies have noticed that social media can significantly influence people's sentiments and opinions about vaccinations. There is a lack of studies on the impact of social norms, herding effects, and social media influencers on people's sentiments and opinions about vaccinations. This culminating experience project extracted and analyzed Twitter data (2021 to 2022) using Twitter API and the RStudio AcdemicTwitterR package to study the impact of social norms, herding effects, and social media influencers on people's sentiments, emotions, …

Potential Use Of Engineered Nanoparticles In Ocean Fertilization For Large-Scale Atmospheric Carbon Dioxide Removal, Peyman Babakhani, Tanapon Phenrat, Mohammed Baalousha M.Sc, Ph.D., Kullapa Soratana, Caroline L. Peacock, Benjamin S. Twining, Michael F. Hochella Jr.

Faculty Publications

Artificial ocean fertilization (AOF) aims to safely stimulate phytoplankton growth in the ocean and enhance carbon sequestration. AOF carbon sequestration efficiency appears lower than natural ocean fertilization processes due mainly to the low bioavailability of added nutrients, along with low export rates of AOF-produced biomass to the deep ocean. Here we explore the potential application of engineered nanoparticles (ENPs) to overcome these issues. Data from 123 studies show that some ENPs may enhance phytoplankton growth at concentrations below those likely to be toxic in marine ecosystems. ENPs may also increase bloom lifetime, boost phytoplankton aggregation and carbon export, and address …

Power In Portrayal: An Exploration Of The Evolving Cold War Relationship Between Germany And America Through Film, Kaleb Wentz

Electronic Theses and Dissertations

The end of the Second World War brought many questions to the United States. One of the greatest among these was what to do with defeated Germany. Many clamored for the dissolution of the former Nazi State and the shameful humbling of its people while others recognized the value of a revitalized Germany as an ally against the looming threat of an emboldened and empowered postwar Soviet Union. Though retribution held sway immediately following the war, the Cold War consensus of an alliance with West Germany and a reimagining of the German people as victims rather than perpetrators won out …

Meningitis Post-Cochlear Implant And Role Of Vaccination, Ghadah A. Alanazi, Aumniyat S. Alrashidi, Khalid S. Alqarni, Saeed A. Al Khozym, Saad Alenzi

Saudi Medical Journal

Objectives: To investigate the incidence, risk factors, and management of meningitis in cochlear implant (CI)users. Methods: A systematic review was carried out using PubMed, Scopus, Web of Science, and Cochrane Central Register. Articles were considered relevant if reported any data on incidence, clinical presentations, the role of vaccination, management, and outcomes of meningitis after CI. Results: A total of 32 studies including 27358 patients were included, and meningitis was reported in only 202 cases. Meningitis occurred in the period ranging from 1 day to 72 months after CI. A total of 55 patients received the pneumococcal vaccine, while 20 patients …

To See Blue Skies, Arete Xu, Special Collections, Fleet Library

9th Baker & Whitehill Student Artists' Book Contest 2023

Entry for the 9th Annual Baker & Whitehill Student Artists' Book Contest. Opening Reception Thursday, March 02, 2023, Fleet Library, Main Reading Room. Juror: Andre Lee Bassuet.

Empirical Study Of Cashback Affiliate Strategy: Evidence From A Cashback Website, Liu Xinyong

Dissertations and Theses Collection (Open Access)

With the rapid development of internet technology, e-commerce has become increasingly prosperous with online shopping increasingly penetrating into the daily life of consumers. Online channel has become an indispensable channel for merchants to reach their customers. To improve sales performance and address competition from rivals, online merchants have developed various promotion methods. Cashback promotion has gradually become one of the popular promotion methods, and attracted attention from scholars. This paper aims to investigate the relationship between cashbacks and consumer behaviors using data on Taobao merchants on a large cashback website in China. Two studies with a large number of transaction …

Implementing Sexual Violence Primary Prevention Programs: A Case Study Of Implementer Perspectives, Rachel Jackson-Gordon, Jacinda K. Dariotis, Bonnie S. Fisher, Victoria Dickman-Burnett

Journal of Youth Development

Sexual violence prevention programs are important for addressing sexual violence and are often implemented in local community and university settings. However, program implementer perspectives are often missing from academic research literature, limiting access to practical knowledge that can provide insights to improving programs and prevention. This study illustrates the landscape of sexual violence primary prevention work in a Midwestern metropolitan area. Seven interviews with community and university implementers took place in 2020, providing information about local prevention programs and expert insights to community prevention culture. Geographic data about implementation locations was also collected to visually assess coverage of preventive services …

Hyperglycemic Hyperosmolar Syndrome (Hhs), Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Rapid Metabolism Fosters Microbial Survival In The Deep, Hot Subseafloor Biosphere, F. Beulig, F. Schubert, R. R. Adhikari, C. Glombitza, V. B. Heuer, K. U. Hinrichs, K. L. Homola, F. Inagaki, B. B. Jørgensen, J. Kallmeyer, S. J.E. Krause, Y. Morono, J. Sauvage, A. J. Spivack, T. Treude

Graduate School of Oceanography Faculty Publications

A fourth of the global seabed sediment volume is buried at depths where temperatures exceed 80 °C, a previously proposed thermal barrier for life in the subsurface. Here, we demonstrate, utilizing an extensive suite of radiotracer experiments, the prevalence of active methanogenic and sulfate-reducing populations in deeply buried marine sediment from the Nankai Trough subduction zone, heated to extreme temperature (up to ~120 °C). The small microbial community subsisted with high potential cell-specific rates of energy metabolism, which approach the rates of active surface sediments and laboratory cultures. Our discovery is in stark contrast to the extremely low metabolic rates …

Diabetic Ketoacidosis, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Ensuring An Inclusive Environment For Deaf And Hard Of Hearing Patients, Joseph Samona Dds, Michael Korleski Rdh, Bsdh, Stephen J. Stefanac Dds, Ms

The Journal of the Michigan Dental Association

This article emphasizes the need for an inclusive environment in dental practice for Deaf and hard of hearing (DHH) patients. It sheds light on the challenges faced by DHH patients during dental appointments, such as communication barriers due to mask-wearing and lack of sign language interpreters. The article highlights the importance of using proper terminology, understanding communication preferences, and providing accommodations to ensure effective communication with DHH patients. It also discusses legal requirements, including the Americans with Disabilities Act, to provide reasonable accommodations. Ensuring inclusivity in dental practice is essential to improving access to care and enhancing oral health outcomes …

Clinician’S Recommendations In Treating Victims And Survivors Of Narcissistic Abuse, Sadaf Shalchian

Loma Linda University Electronic Theses, Dissertations & Projects

Although marriage and family therapists are one of the main providers in treating mental and relational health issues, there is not a significant emphasis on the identification, assessment, and treatment of victims and survivors of narcissistic abuse in COAMFTE-accredited Masters level Marriage and Family Therapy programs (COAMFTE, 2017). This needs assessment aimed to identify the knowledge and clinical skills recommended by clinicians who treat victims and survivors of narcissistic abuse to identify some needs, assessments, and treatment practices that can guide LMFTs in treating this population. This needs assessment explored current literature, research, and academic and clinical resources focused on …

To Prevent Or To Deceive: The Effects Of Organizational Justice On Malingering And Workplace Injury Via Psychological Contract Breach And Safety Climate, Abraham Rico

Electronic Theses, Projects, and Dissertations

We examined organizational factors (e.g., leadership styles, operating with a bottom-line mentality, and management based on inclusion) and their relationship with workplace injuries and malingering in this thesis. One of the goals for this study was to examine the extent to which these organizational factors influence justice perceptions, which in turn affected the outcomes of interest. It was hypothesized that the relationship between the organizational factors and malingering/injuries occurred through the formation of psychological contract breach or through the development of a safety climate. It was hypothesized that the pathways from Transformational Leadership and management based on inclusion will result …

Queering Marianne: Witchcraft As A Means Of Sexual Freedom, Amber Guerena

Electronic Theses, Projects, and Dissertations

This thesis is divided in three parts to argue that Emma in the series, Marianne, is homosexual. The first section explains that the witch, Marianne, embodies Emma’s repressed homosexual desires and that her reintroduction to Emma’s life signifies her break away from heteronormative expectations. The second section centers on how religion contributes to Emma’s internal conflict regarding her sexuality. She struggles with choosing which religion to embrace: Christianity, which doesn’t support homosexuality, or witchcraft, which does support homosexuality. The third section explains the strategic choices that the series took to portray Emma’s acceptance of herself and witchcraft. The series …

Novel Technologies And Their Effect On The Customer Journey: Customers' Sentiment With Tesla App, Andrew Jaymes

Electronic Theses, Projects, and Dissertations

This culminating experience project explores how novel technologies, such as artificial intelligence (AI), the Internet of Things (IoT), and virtual and augmented reality (VR/AR), impact customer experience. The customer journey framework was used to analyze customers' responses to interactions with novel Technologies integrated into Tesla electric vehicles. After gathering customer response data from the Tesla Motors subreddit page, we were able to score customer experiences with the Tesla app, over-the-air software updates, and full self-driving features, using the NRC sentiment lexicon. Our results showed customers tended to express more positive sentiments than negative sentiments when describing their experiences with these …

Predicting Startup Success Using Publicly Available Data, Emily Gavrilenko

Master's Theses

Predicting the success of an early-stage startup has always been a major effort for investors and venture funds. Statistically, there are about 305 million total startups created in a year, but less than 10% of them succeed to become profitable businesses. Accurately identifying the signs of startup growth is the work of countless investors, and in recent years, research has turned to machine learning in hopes of improving the accuracy and speed of startup success prediction.

To learn about a startup, investors have to navigate many different internet sources and often rely on personal intuition to determine the startup’s potential …

Incorporating Andragogy And Cognitive Theory Of Multimedia Learning Into Self-Paced Training And Development Programs, Shanshan Gao

Doctoral Dissertations

In the modern higher educational system, technology permeated almost all the provisions of educational processes and transformed individual learning transactions. Empirical evidence reveals students’ skill gaps in the digitized campus and the real-world work environment driven by technology. Technical training is of high value and in high demand in helping students to develop the skills necessary to carry out schoolwork and be prepared for the real-world work environment. The purpose of this study was to investigate the effectiveness of the combined method of Andragogy and Cognitive Theory of Multimedia Learning (CTML) in enhancing learning results and optimizing students’ learning experience …

Hearing Impaired And Leadership: Struggles Of Individuals With Hearing Loss In The Workplace, John Cleese Relihan

Doctoral Dissertations

With the passing of federal legislations such as the Rehabilitation Act of 1973 and the Americans with Disabilities Act of 1990, Americans believe all issues relating to disability have been addressed. While Americans with disabilities gained civil rights under these two federal laws and educational opportunities have expanded, they are still struggling against the stigma of disability. They encounter many barriers as they enter the workplace and navigate toward leadership roles in their organizations. This narrative phenomenological qualitative study seeks to understand the experiences of individuals with hearing loss as they enter and navigate through their careers. Its purpose is …