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Articles 2251 - 2280 of 39548
Full-Text Articles in Entire DC Network
“Immigration Enforcement Is A Daily Part Of Our Students’ Lives”: School Social Workers’ Perceptions Of Racialized Nested Contexts Of Reception For Immigrant Students, Sophia Rodriguez, Benjamin J. Roth, Leticia Villarreal Sosa
“Immigration Enforcement Is A Daily Part Of Our Students’ Lives”: School Social Workers’ Perceptions Of Racialized Nested Contexts Of Reception For Immigrant Students, Sophia Rodriguez, Benjamin J. Roth, Leticia Villarreal Sosa
School of Social Work Faculty Publications
This qualitative analysis examines school social workers’ equity work for immigrant students, including their perceptions of immigration enforcement and school climates that support or hinder immigrant student experiences. We conceptually expand understandings of nested contexts of reception and racialized organizations across macro, meso, micro levels, and how they affect immigrant students’ educational experiences, mobility, and belonging. Utilizing open-ended responses from a unique national survey data set, we examine school social workers’ perceptions of the macro, meso, micro racialized contexts that immigrant students encounter, how school social worker perceptions reflect racial attitudes as part of the racialized organization of schools in …
Improving The Perioperative Experience Of Patients And Families In A Pediatric Setting, Anjanette Pong
Improving The Perioperative Experience Of Patients And Families In A Pediatric Setting, Anjanette Pong
Student Scholarly Projects
Practice Problem: The experience of surgery for pediatric patients and their families can be dependent on multiple factors including adequate preparation, English language proficiency and realistic expectations. Anxiety can contribute to a negative experience that may result in poor outcomes and a damaging reflection of the healthcare team and organization.
PICOT: The PICOT question that guided this project was: In preoperative pediatric patients and their families, how do therapeutic communication style and the provision of information about the perioperative experience affect their healthcare experience over eight weeks?
Evidence: A multi-modal approach to providing tailored preoperative education for the child and …
Designing A Cohesive And Iconic Brand Identity For Cal Poly Men’S Soccer Club, Oliver Cobb Panlibuton
Designing A Cohesive And Iconic Brand Identity For Cal Poly Men’S Soccer Club, Oliver Cobb Panlibuton
Graphic Communication
When thinking of iconic soccer teams or brands, what comes to mind? Maybe you think of Barcelona, Chelsea, or Manchester United. Whatever the case may be, what these teams have in common is a strong brand identity. Building a strong brand identity is an important aspect of any soccer organization. It can attract sponsors, develop an emotional connection with fans and other stakeholders, support the association’s strategic objectives, and even reduce marketing costs (Kucheriavyi 2019; Essec). The benefits of having a strong brand enable a club to have more time and money to put into other investments like players and …
Teche Lab Logo Design, Lauren Wagner La Grille
Teche Lab Logo Design, Lauren Wagner La Grille
Graphic Communication
In 2020, Cal Poly’s Biomedical Engineering Department changed the name of one of their existing labs, the QPLUS lab, to the TECHE lab. TECHE stands for Transforming Engineers Through Hands-On Engagement and is a lab where biomedical engineering students can work together on projects, prototype ideas, and create solutions that help improve the lives of those who have disabilities.
Since renaming the lab 2 years ago, the biomedical engineering department has not done any other updates to the branding of the TECHE lab and does not currently have a logo to represent the lab. The TECHE lab is a large …
30 Day Outdoor Mindfulness Journal, Alena Sylvia Robinson
30 Day Outdoor Mindfulness Journal, Alena Sylvia Robinson
Graphic Communication
The 30 Day Outdoor Mindfulness Journal seeks to connect users to nature and to themselves through the use of mindfulness practices. It is believed that these practices can have a myriad of positive effects on both the user and our world. Users will experience effects on their physical and mental health, while also growing their connectedness to nature and, ultimately, their desire to protect the environment.
Sustainable Living Edu, Annika E. Furr
Sustainable Living Edu, Annika E. Furr
Graphic Communication
For my senior project, I created a virtual sustainability training program called ‘Sustainable Living Edu’ for students and employees at Cal Poly SLO. There is a lack of environmental literacy at Cal Poly and other campuses in the California State University (CSU) System. Sustainable Living Edu will educate students and employees at Cal Poly about what sustainability is and how to apply sustainable practices into their daily routines.
Averting Escalation And Avoiding War: Lessons From The 1995–1996 Taiwan Strait Crisis, Kristen Gunness, Phillip C. Saunders
Averting Escalation And Avoiding War: Lessons From The 1995–1996 Taiwan Strait Crisis, Kristen Gunness, Phillip C. Saunders
China Strategic Perspectives
This study assesses information-sharing, communication, and policy coordination between U.S. and Taiwan decisionmakers in the 1995–1996 Taiwan Strait Crisis, derives key lessons, considers the implications for a future crisis, and makes recommendations to policymakers.
Tracing The Roots Of Resistance, Collective Action And Solidarity Among Igbo Women, Sebastian Ukoh
Tracing The Roots Of Resistance, Collective Action And Solidarity Among Igbo Women, Sebastian Ukoh
Theses
Most societies have always achieved balance through some internal mechanisms. Achieving gender balance and drawing lines without letting what we may term the "stronger sex" domineer the "weaker sex" is not always easy. Among the Igbos of South Eastern Nigeria, the women have always pressed home their demands without fear. We will be looking at how they have done this for more than a century, especially at the onset of the British colonial enterprise.
A Study Of The Effect Of Sympathetic Framing On Attitudes Toward The Homeless, Marshall Mills
A Study Of The Effect Of Sympathetic Framing On Attitudes Toward The Homeless, Marshall Mills
Honors Capstones
No abstract provided.
Needs-Based Standards Of Practice For The Use Of Forensic Genetic Genealogy In Investigations Of Violence Toward Marginalized Victims, Anthony Redgrave
Needs-Based Standards Of Practice For The Use Of Forensic Genetic Genealogy In Investigations Of Violence Toward Marginalized Victims, Anthony Redgrave
Doctor of Education Program Dissertations
The purpose of this qualitative narrative study was to identify strategies by which forensic genetic genealogy can be applied to cases of unidentified decedents who are from marginalized populations. Three research questions guided this study: (1) What is each affected group most concerned about regarding the use of forensic genetic genealogy to identify marginalized unidentified decedents or perpetrators of violent crime against marginalized group members?, (2) How have the past experiences of individuals in the affected groups contributed to their stance on the use of forensic genetic genealogy?, And (3) How do stakeholders’ opinions on the use of forensic genetic …
Examining The Symbioses Between Bioluminescent Vibrio Species And Ponyfishes In The Indian Ocean And Between Vibrio Species And Crassostrea Virginica In The Gulf Of Mexico, Alexandra Chauvin
Examining The Symbioses Between Bioluminescent Vibrio Species And Ponyfishes In The Indian Ocean And Between Vibrio Species And Crassostrea Virginica In The Gulf Of Mexico, Alexandra Chauvin
Honors Capstones
No abstract provided.
Politics & Marriage: The Generational Gap In Marriage Priorities And Political Ambition Among Black Women In Politics, Torri A. Jackson
Politics & Marriage: The Generational Gap In Marriage Priorities And Political Ambition Among Black Women In Politics, Torri A. Jackson
Honors Capstones
No abstract provided.
Louisiana Children's Trust Fund Annual Report 2021-2022, Elizabeth Winchester, Jada Thomas-Smith, Harleen Sandhu, Aimee H. Moles, Judith L. F. Rhodes
Louisiana Children's Trust Fund Annual Report 2021-2022, Elizabeth Winchester, Jada Thomas-Smith, Harleen Sandhu, Aimee H. Moles, Judith L. F. Rhodes
Reports
Child abuse and neglect is a leading factor in the staggeringly high rates of child mortality in Louisiana. In 2017, Louisiana had 44,793 total referrals for child abuse and neglect of which 19,851 were investigated (CWLA, 2019). Child abuse and neglect can have multiple detrimental effects on a child’s physical, psychological, and behavioral health. Effective prevention efforts are critical to ensuring the immediate and long-term safety and well-being of children in Louisiana. Each year, LCTF selects high-quality proposals and funds a range of prevention efforts to protect children, strengthen family well-being, and educate the public about children’s safety. Local, national, …
Expression Of The Preadipocyte Marker Zfp423 Is Dysregulated Between Well-Differentiated And Dedifferentiated Liposarcoma, Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau, Z. Elizabeth Floyd
Expression Of The Preadipocyte Marker Zfp423 Is Dysregulated Between Well-Differentiated And Dedifferentiated Liposarcoma, Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau, Z. Elizabeth Floyd
Division of Basic Science Faculty Publications
Background: Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential. Dedifferentiated liposarcoma (DDLPS) is highly aggressive and has an overall 5-year survival rate of 30% as compared to 90% for well-differentiated liposarcoma (WDLPS). This discrepancy may be connected to their potential to form adipocytes, where WDLPS is adipogenic but DDLPS is adipogenic-impaired. Normal adipogenesis requires Zinc Finger Protein 423 (ZFP423), a transcriptional coregulator of Perixosome Proliferator Activated Receptor gamma (PPARG2) mRNA expression that defines committed preadipocytes. Expression of ZFP423 in preadipocytes is promoted by Seven-In-Absentia Homolog …
Ulk1 Inhibition Attenuates Telomerase Activity In Hepatic Cells, Sana Raza, Sangam Rajak, Jyotika Srivastava, Archana Tewari, Pratima Gupta, Bandana Chakravarti, Sujoy Ghosh, Chandra P. Chaturvedi, Rohit A. Sinha
Ulk1 Inhibition Attenuates Telomerase Activity In Hepatic Cells, Sana Raza, Sangam Rajak, Jyotika Srivastava, Archana Tewari, Pratima Gupta, Bandana Chakravarti, Sujoy Ghosh, Chandra P. Chaturvedi, Rohit A. Sinha
Division of Basic Science Faculty Publications
Autophagy and telomere maintenance are two cellular survival processes that show a strong correlation during human ageing and cancer growth, however, their causal relationship remains unclear. In this study, using an unbiased transcriptomics approach, we uncover a novel role of autophagy genes in regulating telomere extension and maintenance pathways. Concomitantly, the pharmacological inhibition of ULK1 (Unc-51 like autophagy activating kinase 1) attenuated human telomerase reverse transcriptase (hTERT) gene expression and telomerase activity in HepG2 cells. Furthermore, the suppression of telomerase activity upon ULK1 inhibition was associated with telomere shortening and onset of cellular senescence in HepG2 cells. These results, thus, …
Evaluation Of Light-Logging Geolocators To Study Mottled Duck Nesting Ecology, Kevin M. Ringelman, Michael G. Brasher, Joseph R. Marty, David A. Butler, Stephen Mcdowell, Richard Temple
Evaluation Of Light-Logging Geolocators To Study Mottled Duck Nesting Ecology, Kevin M. Ringelman, Michael G. Brasher, Joseph R. Marty, David A. Butler, Stephen Mcdowell, Richard Temple
Faculty Publications
Geolocators are small devices that record and store time-stamped light levels that researchers typically use to approximate the latitude and longitude of small birds across the annual cycle. However, when geolocators are affixed to leg bands of larger-bodied birds, nest incubation by females interrupts the daily pattern of light and darkness. Thus, geolocators can provide information on nesting propensity, nest success, and renesting intensity; these demographic parameters are both difficult to measure unobtrusively and are critically important in determining population dynamics of birds, especially ducks. Here, we deployed 240 geolocators on mottled ducks Anas fulvigula in Louisiana and Texas in …
The 2018 World Cancer Research Fund (Wcrf)/American Institute For Cancer Research (Aicr) Score And Diabetes Risk In The Diabetes Prevention Program Outcomes Study (Dppos), Marissa M. Shams-White, Ashley H. Tjaden, Sharon L. Edelstein, Sarah Bassiouni, Lisa L. Kahle, Catherine Kim, Xavier Pi-Sunyer, Karla A. Temple, Elizabeth M. Venditti, Jill Reedy, Brandy M. Heckman-Stoddard, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. Smith, Lisa L. Smith
The 2018 World Cancer Research Fund (Wcrf)/American Institute For Cancer Research (Aicr) Score And Diabetes Risk In The Diabetes Prevention Program Outcomes Study (Dppos), Marissa M. Shams-White, Ashley H. Tjaden, Sharon L. Edelstein, Sarah Bassiouni, Lisa L. Kahle, Catherine Kim, Xavier Pi-Sunyer, Karla A. Temple, Elizabeth M. Venditti, Jill Reedy, Brandy M. Heckman-Stoddard, George A. Bray, Kishore M. Gadde, Iris W. Culbert, Jennifer Arceneaux, Annie Chatellier, Amber Dragg, Catherine M. Champagne, Crystal Duncan, Barbara Eberhardt, Frank Greenway, Fonda G. Guillory, April A. Herbert, Michael L. Jeffirs, Betty M. Kennedy, Erma Levy, Monica Lockett, Jennifer C. Lovejoy, Laura H. Morris, Lee E. Melancon, Donna H. Ryan, Deborah A. Sanford, Kenneth G. Smith, Lisa L. Smith
Population and Public Health Science Faculty Publications
Background: The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) 3rd expert report highlights up-to-date Cancer Prevention Recommendations that may reduce burdens of many chronic diseases, including diabetes. This study examined if following a lifestyle that aligns with the recommendations – assessed via the 2018 WCRF/AICR Score – was associated with lower risk of type 2 diabetes in high-risk adults participating in the Diabetes Prevention Program Outcomes Study (DPPOS). Methods: The Diabetes Prevention Program (DPP) randomized adults at high risk for diabetes to receive a lifestyle intervention (ILS), metformin (MET) or a placebo (PLB) (mean: 3.2 years), with …
A Collaborative Approach To Adopting/Adapting Guidelines. The Australian 24-Hour Movement Guidelines For Children (5-12 Years) And Young People (13-17 Years): An Integration Of Physical Activity, Sedentary Behaviour, And Sleep, Anthony D. Okely, Davina Ghersi, Sarah P. Loughran, Dylan P. Cliff, Trevor Shilton, Rachel A. Jones, Rebecca M. Stanley, Julie Sherring, Natalie Toms, Simon Eckermann, Timothy S. Olds, Zhiguang Zhang, Anne Maree Parrish, Lisa Kervin, Sandra Downie, Jo Salmon, Clair Bannerman, Tamie Needham, Elaine Marshall, Jordy Kaufman, Layne Brown, Janecke Wille, Greg Wood, David R. Lubans, Stuart J.H. Biddle, Shane Pill, Anthea Hargreaves, Natalie Jonas, Natasha Schranz, Perry Campbell, Karen Ingram, Hayley Dean, Adam Verrender, Yvonne Ellis
A Collaborative Approach To Adopting/Adapting Guidelines. The Australian 24-Hour Movement Guidelines For Children (5-12 Years) And Young People (13-17 Years): An Integration Of Physical Activity, Sedentary Behaviour, And Sleep, Anthony D. Okely, Davina Ghersi, Sarah P. Loughran, Dylan P. Cliff, Trevor Shilton, Rachel A. Jones, Rebecca M. Stanley, Julie Sherring, Natalie Toms, Simon Eckermann, Timothy S. Olds, Zhiguang Zhang, Anne Maree Parrish, Lisa Kervin, Sandra Downie, Jo Salmon, Clair Bannerman, Tamie Needham, Elaine Marshall, Jordy Kaufman, Layne Brown, Janecke Wille, Greg Wood, David R. Lubans, Stuart J.H. Biddle, Shane Pill, Anthea Hargreaves, Natalie Jonas, Natasha Schranz, Perry Campbell, Karen Ingram, Hayley Dean, Adam Verrender, Yvonne Ellis
Population and Public Health Science Faculty Publications
Abstract: Background: In 2018, the Australian Government updated the Australian Physical Activity and Sedentary Behaviour Guidelines for Children and Young People. A requirement of this update was the incorporation of a 24-hour approach to movement, recognising the importance of adequate sleep. The purpose of this paper was to describe how the updated Australian 24-Hour Movement Guidelines for Children and Young People (5 to 17 years): an integration of physical activity, sedentary behaviour and sleep were developed and the outcomes from this process. Methods: The GRADE-ADOLOPMENT approach was used to develop the guidelines. A Leadership Group was formed, who identified existing …
Uterine Lumen Fluid Is Metabolically Semi-Autonomous, Constantine A. Simintiras, Jessica N. Drum, Hongyu Liu, M. Sofia Ortega, Thomas E. Spencer
Uterine Lumen Fluid Is Metabolically Semi-Autonomous, Constantine A. Simintiras, Jessica N. Drum, Hongyu Liu, M. Sofia Ortega, Thomas E. Spencer
Faculty Publications
Uterine lumen fluid (ULF) is central to successful pregnancy establishment and maintenance, and impacts offspring wellbeing into adulthood. The current dogma is that ULF composition is primarily governed by endometrial glandular epithelial cell secretions and influenced by progesterone. To investigate the hypothesis that ULF is metabolically semi-autonomous, ULF was obtained from cyclic heifers, and aliquots incubated for various durations prior to analysis by untargeted semi-quantitative metabolomic profiling. Metabolite flux was observed in these ULF isolates, supporting the idea that the biochemical makeup of ULF is semi-autonomously dynamic due to enzyme activities. Subsequent integrative analyses of these, and existing, data predict …
Improving Customer Satisfaction For Smes In Emerging Countries: A Comparative Study Of Hungary And Indonesia, Santi Setyaningsih, Peter Kelle
Improving Customer Satisfaction For Smes In Emerging Countries: A Comparative Study Of Hungary And Indonesia, Santi Setyaningsih, Peter Kelle
Faculty Publications
Improving Customer Satisfaction (CS) is a key strategical goal for companies, especially for Small and Medium-Sized Enterprises (SMEs). The objective of this research is to find and rank the major factors supporting CS. We focus on SMEs in two emerging markets located in two countries with different geographical and supply chain environments. We test a conceptual framework that includes several factors supporting CS. The data were collected from Hungarian and Indonesian SMEs by online questionnaire. We used statistical analysis such as Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), and Structural Equation Model (SEM) to test our model and hypothesis. …
Angles Between Subspaces And Nearly Optimal Approximation In Gfem, Robert Lipton, Paul Sinz, Michael Stuebner
Angles Between Subspaces And Nearly Optimal Approximation In Gfem, Robert Lipton, Paul Sinz, Michael Stuebner
Faculty Publications
The Generalized Finite Element Methods (GFEM) are known for accurately resolving local features in heterogeneous media. Recent numerical experiments have shown that the use of local bases made from A-harmonic extensions of well chosen boundary data have nearly optimal approximation properties. In this paper we show that the explanation is geometric and given by the angle between any finite dimensional approximation space and the optimal finite dimensional approximation space introduced in (Babǔska and Lipton, 2011). The effect of the angle is quantified by an upper bound on the convergence rate. This rate is seen in the numerical simulations where local …
Medical Physics Workforce In The United States, Wayne D. Newhauser, Dustin A. Gress, Michael D. Mills, David W. Jordan, Steven G. Sutlief, Melissa C. Martin, Edward Jackson
Medical Physics Workforce In The United States, Wayne D. Newhauser, Dustin A. Gress, Michael D. Mills, David W. Jordan, Steven G. Sutlief, Melissa C. Martin, Edward Jackson
Faculty Publications
No abstract provided.
Probiotic Incorporation Into Yogurt And Various Novel Yogurt-Based Products, Douglas W. Olson, Kayanush J. Aryana
Probiotic Incorporation Into Yogurt And Various Novel Yogurt-Based Products, Douglas W. Olson, Kayanush J. Aryana
Faculty Publications
Probiotics are commonly added to yogurt to provide many health benefits for the consumer. A description is provided for some commonly used probiotics in yogurt. A GRAS (generally recognized as safe) list of probiotic bacteria that can be added to yogurt or similar types of products is provided. Additionally, prebiotics, synbiotics (combination of prebiotics and probiotics), postbiotics, paraprobiotics, and psychobiotics can be added to yogurt. Probiotic yogurt can come in various forms in addition to spoonable yogurt, and yogurt can be used as an ingredient in other food products. Many useful functional ingredients can be applied to probiotic yogurt. The …
Labrad : Vol 47, Issue 2 - December 2022, Aga Khan University Hospital, Karachi
Labrad : Vol 47, Issue 2 - December 2022, Aga Khan University Hospital, Karachi
LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives
- From the Editor’s Desk
- Case Quiz
- Contrast Enhanced Spectral Mammography Clinical Usefulness of Biochemical Parameters in Prenatal Diagnosis of Down Syndrome In First and Second Trimester
- The Science of Efficiency in a Clinical Laboratory
- Updates in new WHO Blue Book
- Monkeypox vs. COVID-19
- From the Diary of a Researcher- Notes on Understanding Beta-Thalassemia and Metabolic Bone Disease
- Significance of Audit in a Clinical Laboratory
- Microsatellite Instability (MSI) Testing
- Pre-Analytical Variables Affecting Coagulation Testing
- Grading of Soft Tissue Sarcomas
- Recent Updates in 2022 WHO Classification of Thyroid Neoplasms
- MMR and MSI Testing in Malignancies
- Transforming Pedagogical Framework of Pathology through Social …
Inspire : Vol 5, Issue 12, Department Of Medicine
Inspire : Vol 5, Issue 12, Department Of Medicine
INSPIRE – Department of Medicine Archives
- Message from the Chair
- 7th WOHC Singapore
- World Stroke Day
- PZP Hospitalist Grand Round
- PADCON
- PZP Hospitalist Grand Round
- International Kidney Transplant Symposium
- UPDATES ON COPD
- In-depth- featuring Assistant Prof. Dr Mehreen Arshad
- What are Academics Around the World Reading This Month?
- Publications
Aligning Instruction With Extension Professional Competencies For An Enhanced Undergraduate Extension Education Minor, Joseph L. Donaldson, Wendy Warner, Jacklyn Bruce, Joy Morgan, Harriett Coleman Edwards, Rose Vaughan
Aligning Instruction With Extension Professional Competencies For An Enhanced Undergraduate Extension Education Minor, Joseph L. Donaldson, Wendy Warner, Jacklyn Bruce, Joy Morgan, Harriett Coleman Edwards, Rose Vaughan
Journal of Human Sciences and Extension
This paper reports on a three-year initiative to enhance the undergraduate Extension Education minor at a state land-grant university. Specific initiatives to improve the undergraduate Extension Education minor curriculum involved (a) revising the Extension Education minor due to varied curriculum and faculty changes and (b) aligning eight Extension Education courses’ units of study with Extension professional competency domains. The described processes helped understand the Extension Education curriculum by mapping competency domains and showing which domains were and were not taught in the eight courses. A key recommendation is to incorporate the alignment of Extension Education curriculum and Extension professional competencies …
Smce Model For Commercial Areas Suitability In Serang City, Salsa Muafiroh, Adi Wibowo
Smce Model For Commercial Areas Suitability In Serang City, Salsa Muafiroh, Adi Wibowo
Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)
Commercial areas refer to specific zones designated for business activities, such as trade, retail, and industry, which play a critical role in supporting regional economic development. In the case of Serang City, the government has planned its development as a hub for commerce and industry. However, selecting an optimal location for commercial areas involves addressing challenges related to multiple criteria and alternative options, each with varying advantages and trade-offs, which often complicates the decision-making process. This research aims to analyze spatial modeling using simulations based on the Spatial Multi-Criteria Evaluation (SMCE) method, supported by ILWIS software to determine the most …
How California Lawmakers Responded Legislatively To The #Metoo Movement, Chris Micheli, Ashley Hoffman
How California Lawmakers Responded Legislatively To The #Metoo Movement, Chris Micheli, Ashley Hoffman
University of the Pacific Law Review
No abstract provided.
Sources Of Calcium At Connexin 36 Gap Junctions In The Retina, Pui Man Rosalind Lai, Jee-Yeon Ryu, Sang-Cheol Park, Bradley A Gross, Lawrence D Dickinson, Sarajune Dagen, Mohammad Ali Aziz-Sultan, Alan S Boulos, Daniel L Barrow, H Hunt Batjer, Spiros Blackburn, Edward F Chang, P Roc Chen, Geoffrey P Colby, Garth Rees Cosgrove, Carlos A David, Arthur L Day, Kai U Frerichs, Mika Niemela, Steven G Ojemann, Nirav J Patel, Xiangen Shi, Edison P Valle-Giler, Anthony C Wang, Babu G Welch, Edie E Zusman, Scott T Weiss, Rose Du
Sources Of Calcium At Connexin 36 Gap Junctions In The Retina, Pui Man Rosalind Lai, Jee-Yeon Ryu, Sang-Cheol Park, Bradley A Gross, Lawrence D Dickinson, Sarajune Dagen, Mohammad Ali Aziz-Sultan, Alan S Boulos, Daniel L Barrow, H Hunt Batjer, Spiros Blackburn, Edward F Chang, P Roc Chen, Geoffrey P Colby, Garth Rees Cosgrove, Carlos A David, Arthur L Day, Kai U Frerichs, Mika Niemela, Steven G Ojemann, Nirav J Patel, Xiangen Shi, Edison P Valle-Giler, Anthony C Wang, Babu G Welch, Edie E Zusman, Scott T Weiss, Rose Du
Faculty, Staff and Student Publications
Background and Objectives
While somatic mutations have been well-studied in cancer, their roles in other complex traits are much less understood. Our goal is to identify somatic variants that may contribute to the formation of saccular cerebral aneurysms.
Methods
We performed whole-exome sequencing on aneurysm tissues and paired peripheral blood. RNA sequencing and the CRISPR/Cas9 system were then used to perform functional validation of our results.
Results
Somatic variants involved in supervillin (SVIL) or its regulation were found in 17% of aneurysm tissues. In the presence of a mutation in the SVIL gene, the expression level of SVIL …