Digital Commons Network^™

Rad51-Mediated Interhomolog Recombination During Budding Yeast Meiosis Is Promoted By The Meiotic Recombination Checkpoint And The Conserved Pif1 Helicase, Andrew Ziesel, Qixuan Weng, Jasvinder S. Ahuja, Abhishek Bhattacharya, Raunak Dutta, Evan Cheng, G. Valentin Borner Ph.D., Michael Lichten, Nancy M. Hollingsworth

Biological, Geological, and Environmental Faculty Publications

During meiosis, recombination between homologous chromosomes (homologs) generates crossovers that promote proper segregation at the first meiotic division. Recombination is initiated by Spo11-catalyzed DNA double strand breaks (DSBs). 5' end resection of the DSBs creates 3' single strand tails that two recombinases, Rad51 and Dmc1, bind to form presynaptic filaments that search for homology, mediate strand invasion and generate displacement loops (D-loops). D-loop processing then forms crossover and noncrossover recombinants. Meiotic recombination occurs in two temporally distinct phases. During Phase 1, Rad51 is inhibited and Dmc1 mediates the interhomolog recombination that promotes homolog synapsis. In Phase 2, Rad51 becomes active …

Singapore Management University Report To Stakeholders 2021/2022, Singapore Management University

Report to Stakeholders

The title of the annual report, “Our Evolving Garden”, points to how the University continues to develop and progress as “One SMU”. With the world now learning to live with COVID-19 as endemic, the last year has been one in which SMU students have been able to resume many of the activities that contribute towards providing a transformative education. For example, they were able to attend many more events on campus and to travel overseas for internships, exchanges, and community service projects. Faculty too were able to attend academic conferences and meet with educational partners, business connections and research associates …

Immersive Inoculation: Testing If Architecture Can Become A Form Of Emotional Supplementation, Julia Kazubowsi, Chloe De Marco

Architecture Thesis Prep

The environments, objects, and spaces we encounter rub off on us, even if we don't notice. Like a human interaction, every inanimate encounter we have have with surrounding objects and architecture has a positive or negative affect on us.

We recognize that ordinary things have a surprising power to create extraordinary feelings and reactions. This thesis propose a visual medium that bridges the gap between us and the inanimate. Where we meet in the middle is an architectural experience that is emotionally charged, introducing specific emotions to the body. Just as movies, books, and happy pills elicit a response from …

Paradigm Of The Post Natural: Critiquing Capitalist Ideals Through Environmental Degradation, Andrea De Haro, Charlotte Bascombe

Architecture Thesis Prep

There is an unspoken value in the destructiveness caused by design that is exposed through the exploitation of natural resources. This thesis seeks to exemplify the aesthetic value inherent within these newly defined environments. Nature is a source for human consumption, and as such it has developed into a commodity. By now it should be made evident that humanity’s presence is everywhere. There is no ecosystem left unturned by human manipulation Iin this respect, nature is dead. Deforested sites of oil fracking leave mile long toxic ponds highlighting the destructive pursuits that capitalism creates. Chernobyl showcases how human errors in …

When I Was Not Looking, Kathryn Parenti

The Prairie Light Review

No abstract provided.

Tri-Ag News Academics Research Extension College Of Agriculture Sciences - Spring/Summer 2022, Prairie View A&M University

Prairie View Magazine Collection

No abstract provided.

Lifestyle Interventions For Prevention And Management Of Diet-Linked Non-Communicable Diseases Among Adults In Arab Countries, Maryam Naveed Muhammad Tariq, Lily Stojanovska, Ayesha S. Al Dhaheri, Leila Cheikh Ismail, Vasso Apostolopoulos, Habiba I. Ali

CoMHS Faculty Work

The increased incidences of diet-related non-communicable diseases (NCDs) such as diabetes, obesity, and cardiovascular diseases among adults are becoming the chief public health concern in most Arab countries. Economic expansion has contributed to a nutrition shift from a traditional seasonal diet to Westernized eating habits coupled with a sedentary lifestyle. Despite the rising concern for NCD mortality, public health policies are inadequately addressed. This narrative review aims to discuss the effectiveness of nutritional interventions focusing on diet and physical activity in the management of NCDs among Arab adults. A comprehensive literature search was performed using different database platforms such as …

Tlr4/Nfκb-Mediated Anti-Inflammatory And Antioxidative Effect Of Hexanic And Ethanolic Extracts Of Curcuma Longa L. In Buffalo Mammary Epithelial Cells, Insha Amin, Shahzada Mudasir Rashid, Sheikh Shubeena, Ishraq Hussain

Faculty and Student Publications

Mastitis is the commonest disease of bovines imposing a great economic setback and a drastic public health concern worldwide. Antibiotic resistance is the preliminary con of excessive antibiotics use for disease treatment. Studies validate an alarming increase in the antibiotic resistance of both humans and animals. For ages, medicinal plants have been used to treat a number of ailments in humans and animals, including mastitis. Curcuma longa, or turmeric, is the prerequisite in Indian cooking and has been used in traditional medicine for its magical properties. The rhizome of C. longa possesses significant anti-inflammatory, antibacterial, antifungal, and antioxidative properties. In …

Antitrypanosomal, Antitopoisomerase-I, And Cytotoxic Biological Evaluation Of Some African Plants Belonging To Crassulaceae; Chemical Profiling Of Extract Using Uhplc/Qtof-Ms/Ms, Mostafa M. Hegazy, Wael M. Afifi, Ahmed M. Metwaly, Mohamed M. Radwan

Faculty and Student Publications

In our continuous study for some African plants as a source for antitrypanosomally and cytotoxic active drugs, nine different plants belonging to the Crassulaceae family have been selected for the present study. Sedum sieboldii leaves extract showed an antitrypanosomal activity against Trypanosoma brucei with an IC50 value of 8.5 µg/mL. In addition, they have cytotoxic activities against (HCT-116), (HEPG-2) and (MCF-7), with IC50 values of 28.18 ± 0.24, 22.05 ± 0.66, and 26.47 ± 0.85 µg/mL, respectively. Furthermore, the extract displayed inhibition against Topoisomerase-1 with an IC50 value of 1.31 µg/mL. It showed the highest phenolics and flavonoids content among …

Discovery Of A Lectin Domain That Regulates Enzyme Activity In Mouse N-Acetylglucosaminyltransferase-Iva (Mgat4a), Masamichi Nagae, Tetsuya Hirata, Hiroaki Tateno, Sushil K. Mishra

Faculty and Student Publications

N-Glycosylation is a common post-translational modification, and the number of GlcNAc branches in N-glycans impacts glycoprotein functions. N-Acetylglucosaminyltransferase-IVa (GnT-IVa, also designated as MGAT4A) forms a β1-4 GlcNAc branch on the α1-3 mannose arm in N-glycans. Downregulation or loss of GnT-IVa causes diabetic phenotypes by dysregulating glucose transporter-2 in pancreatic β-cells. Despite the physiological importance of GnT-IVa, its structure and catalytic mechanism are poorly understood. Here, we identify the lectin domain in mouse GnT-IVa’s C-terminal region. The crystal structure of the lectin domain shows structural similarity to a bacterial GlcNAc-binding lectin. Comprehensive glycan binding assay using 157 glycans and solution NMR …

Milk-Compositional Study Of Metabolites And Pathogens In The Milk Of Bovine Animals Affected With Subclinical Mastitis, Aarif Ali, Manzoor Ur Rahman Mir, Showkat Ahmad Ganie, Saima Mushtaq

Faculty and Student Publications

Bovine milk is an important food component in the human diet due to its nutrient-rich metabolites. However, bovine subclinical mastitis alters the composition and quality of milk. In present study, California mastitis testing, somatic cell count, pH, and electrical conductivity were used as confirmatory tests to detect subclinical mastitis. The primary goal was to study metabolome and identify major pathogens in cows with subclinical mastitis. In this study, 29 metabolites were detected in milk using gas chromatography–mass spectrometry. Volatile acidic compounds, such as hexanoic acid, hexadecanoic acid, lauric acid, octanoic acid, n-decanoic acid, tricosanoic acid, tetradecanoic acid, and hypogeic acid …

Validated Determination Of Nrg1 Ig-Like Domain Structure By Mass Spectrometry Coupled With Computational Modeling, Niloofar Abolhasani Khaje, Alexander Eletsky, Sarah E. Biehn, Charles K. Mobley

Faculty and Student Publications

High resolution hydroxyl radical protein footprinting (HR-HRPF) is a mass spectrometry-based method that measures the solvent exposure of multiple amino acids in a single experiment, offering constraints for experimentally informed computational modeling. HR-HRPF-based modeling has previously been used to accurately model the structure of proteins of known structure, but the technique has never been used to determine the structure of a protein of unknown structure. Here, we present the use of HR-HRPF-based modeling to determine the structure of the Ig-like domain of NRG1, a protein with no close homolog of known structure. Independent determination of the protein structure by both …

A Distinct Mechanism Of C-Type Inactivation In The Kv-Like Kcsa Mutant E71v, Ahmed Rohaim, Bram J. A. Vermeulen, Jing Li, Felix Kümmerer

Faculty and Student Publications

C-type inactivation is of great physiological importance in voltage-activated K+ channels (Kv), but its structural basis remains unresolved. Knowledge about C-type inactivation has been largely deduced from the bacterial K+ channel KcsA, whose selectivity filter constricts under inactivating conditions. However, the filter is highly sensitive to its molecular environment, which is different in Kv channels than in KcsA. In particular, a glutamic acid residue at position 71 along the pore helix in KcsA is substituted by a valine conserved in most Kv channels, suggesting that this side chain is a molecular determinant of function. Here, a combination of X-ray crystallography, …

Predicting Geotechnical Parameters From Seismic Wave Velocity Using Artificial Neural Networks, Fatema Tuz Johora, Craig J. Hickey, Hakan Yasarer

Faculty and Student Publications

Geotechnical investigation plays an indispensable role in site characterization and provides necessary data for various construction projects. However, geotechnical measurements are time-consuming, point-based, and invasive. Non-destructive geophysical measurements (seismic wave velocity) can complement geotechnical measurements to save project money and time. However, correlations between geotechnical and seismic wave velocity are crucial in order to maximize the benefit of geophysical information. In this work, artificial neural networks (ANNs) models are developed to forecast geotechnical parameters from seismic wave velocity. Specifically, published seismic wave velocity, liquid limit, plastic limit, water content, and dry density from field and laboratory measurements are used to …

Supervised Acoustic Embeddings And Their Transferability Across Languages, Sreepratha Ram, Hanan Aldarmaki

Natural Language Processing Faculty Publications

In speech recognition, it is essential to model the phonetic content of the input signal while discarding irrelevant factors such as speaker variations and noise, which is challenging in low-resource settings. Self-supervised pretraining has been proposed as a way to improve both supervised and unsupervised speech recognition, including frame-level feature representations and Acoustic Word Embeddings (AWE) for variable-length segments. However, self-supervised models alone cannot learn perfect separation of the linguistic content as they are trained to optimize indirect objectives. In this work, we experiment with different pre-trained self-supervised features as input to AWE models and show that they work best …

Around The World In Two Days: Walt Disney's Epcot Center And The World's Fair Tradition, Annie Davis

Student Scholarship & Creative Works

This work views the performative and consumerist traditions of the World's Fair and how Walt Disney World's EPCOT Center was essentially created to exist as a "permanent World's Fair" in theme park form. From viewing the 1904 Louisiana Purchase Exposition in St. Louis and the 1964-1965 New York World's Fair alongside Epcot Center (1982) the similarities in the visitor experience are analyzed. Walt Disney's presence at the 1964-1965 New York World's Fair seems to work as testing grounds for ideas with lower stakes than presenting permanent attractions, some of which would later be moved to the parks. Epcot Center offered …

Muhlenberg Magic, Lehigh Valley Health Network

LVHN documents

No abstract provided.

Camelira: An Arabic Multi-Dialect Morphological Disambiguator, Ossama Obeid, Go Inoue, Nizar Habash

Computer Vision Faculty Publications

We present Camelira, a web-based Arabic multi-dialect morphological disambiguation tool that covers four major variants of Arabic: Modern Standard Arabic, Egyptian, Gulf, and Levantine. Camelira offers a user-friendly web interface that allows researchers and language learners to explore various linguistic information, such as part-of-speech, morphological features, and lemmas. Our system also provides an option to automatically choose an appropriate dialect-specific disambiguator based on the prediction of a dialect identification component. Camelira is publicly accessible at http://camelira.camel-lab.com.

State Digital Services Taxes: A Good And Permissible Idea (Despite What You Might Have Heard), Young Ran (Christine) Kim, Darien Shanske

Notre Dame Law Review

Tax systems have been struggling to adapt to the digitalization of the economy. At the center of the struggles is taxing digital platforms, such as Google or Facebook. These immensely profitable firms have a business model that gives away “free” services, such as searching the web. The service is not really free; it is paid for by having the users watch ads and tender data. Traditional tax systems are not designed to tax such barter transactions, leaving a gap in taxation.

One response, pioneered in Europe, has been the creation of a wholly new tax to target digital platforms: the …

Pasta: Table-Operations Aware Fact Verification Via Sentence-Table Cloze Pre-Training, Zihui Gu, Ju Fan, Nan Tang, Preslav Nakov, Xiaoman Zhao, Xiaoyong Du

Natural Language Processing Faculty Publications

Fact verification has attracted a lot of research attention recently, e.g., in journalism, marketing, and policymaking, as misinformation and disinformation online can sway one's opinion and affect one's actions. While fact-checking is a hard task in general, in many cases, false statements can be easily debunked based on analytics over tables with reliable information. Hence, table-based fact verification has recently emerged as an important and growing research area. Yet, progress has been limited due to the lack of datasets that can be used to pre-train language models (LMs) to be aware of common table operations, such as aggregating a column …

Greener: Graph Neural Networks For News Media Profiling, Panayot Panayotov, Utsav Shukla, Husrev T. Sencar, Mohamed Nabeel, Preslav Nakov

Natural Language Processing Faculty Publications

We study the problem of profiling news media on the Web with respect to their factuality of reporting and bias. This is an important but under-studied problem related to disinformation and “fake news” detection, but it addresses the issue at a coarser granularity compared to looking at an individual article or an individual claim. This is useful as it allows to profile entire media outlets in advance. Unlike previous work, which has focused primarily on text (e.g., on the articles published by the target website, or on the textual description in their social media profiles or in Wikipedia), here we …

Zero-Defect Manufacturing Utilizing Autonomation In Aerospace, Quinton L. Marks, Abeni El-Amin Ph.D.

Management Faculty Publications

Multifunctional manufacturing processes are comprised of zero-defect manufacturing (ZDM), which is inherently a complex process because of the simultaneous operations needed to accomplish zero defects. The application of the ZDM philosophy, together with autonomation, presents significant challenges and opportunities for the implementation of new processes that contribute to innovative manufacturing production processes. An emphasis must be on developing fully integrated, operative solutions, employing many quality systems, digitization, data analytics, and industry standards such as AS9100, ISO 9001, and Advanced Product Quality Planning.

Minutes, December 2022, University Of Dayton. College Of Arts And Sciences

Documents of the College of Arts and Sciences Academic Affairs Committee

Minutes from organizational meeting for Academic Affairs Committee

Help Or Hindrance: How Social Media Affects The Selection And Hiring Processes Of Businesses, Alexandra Krska

Management Undergraduate Honors Theses

Continually, young people have been advised to be conscientious of the imagery they put on social media regarding their personal lives in preparation for employment selection. However, the use of social media in the selection process may cause Human Resource professionals to have inadvertent biases toward candidates among other moral and ethical issues. Through extensive research of the thoughts and actions of a plethora of different corporate professionals, I will analyze whether using social media as a tool in the selection process authentically produces positive unbiased results, or whether social media poses more ethical issues. With the hopes to create …

Interview With Mike Legaspi, Andrea Generalao

Immigrant Leaders

An interview with Mike Legaspi, an immigrant leader from Migrante. The interview covers life before immigrating, arrival and integration, and political participation.

A Cybersecurity Assessment Of Health Data Ecosystems, Michelle N. Halsey

Cyber Operations and Resilience Program Graduate Projects

This paper is an exploratory study that investigates data collected and used by health plans and reviews the laws and regulations governing this data to identify the gaps in protections and provide recommendations for eliminating these gaps. Health insurance companies collect a wide array of data about the people they insure, data that is often only peripherally relevant to the service these companies provide. The data environment currently consists of seven categories of data: personal health information, summary health information, personally identifiable information, financial information, professional information, biometric information, and lifestyle data or social indicators of health. Much of this …

Politicizing The Pandemic: Covid-19 And Its Impact On The Nigerian Economy, John Shola Olanrewaju, Agaptus Nwozor, Ajibola Abdulwasiu Abdulrahaman

Faculty and Student Open Access Publications

This study aims to examine the connection between international politics that characterized the outbreak of COVID-19, mainly between the United States of America and China and the devastating impact of the second wave outbreak on the Nigerian economy. At the initial stage of the pandemic on the Chinese mainland, the economy of China experienced a significant decline. The efficacy of China’s response to COVID-19 led to a fractional economic recovery during the pandemic. However, the internationalization of COVID-19 was greeted with a second wave in most advanced countries, such as the United States of America, Italy, and the United Kingdom, …

Issue 408: December 1-15, 2022, The Local Voice

The Local Voice

No abstract provided.

Interview With Alan Andersen, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

Jud Ms 24 Frederic C. Weinberg Collection, Katelynn Paul

Search the Manuscript Collection (Finding Aids)

Biographical Note:

Frederic Weinberg was born in Metuchen, New Jersey. He graduated from Metuchen High School and pursued a bachelor’s degree in English from the University of Connecticut in 1969. After receiving his initial degree in English, he enrolled in the University of New Hampshire’s program in Library Science. In 1972 he was accepted into a special program in Educational Media at Boston University where he received a master’s degree in Education. In 1977 Frederic and his family joined the Beth Israel Congregation. He later assisted the congregation as a researcher and archivist. Currently Frederic is a regional coordinator for …