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2022

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Synthesis, Molecular Modeling, And Biological Evaluation Of Novel Imatinib Derivatives Asanticancer Agents, Fulya Günay, Sevcan Balta, Yuk Yin Ng, Özlem Ulucan Açan, Zühal Turgut, Ömer Tahi̇r Günkara Jan 2022

Synthesis, Molecular Modeling, And Biological Evaluation Of Novel Imatinib Derivatives Asanticancer Agents, Fulya Günay, Sevcan Balta, Yuk Yin Ng, Özlem Ulucan Açan, Zühal Turgut, Ömer Tahi̇r Günkara

Turkish Journal of Chemistry

Different derivatives of imatinib were synthesized by a 3-step reaction method. The structures of the new compounds were characterized by spectroscopic methods. For quantitative evaluation of the biological activity of the compounds, MTT assays were performed, where four BCR-ABL negative leukemic cell lines (Jurkat, Reh, Nalm-6 and Molt-4), one BCR-ABL positive cell line (K562), and one non-leukemic cell line (Hek293T) were incubated with various concentrations of the derivatives. Although imatinib was specifically designed for the BCR-ABL protein, our results showed that it was also effective on BCR-ABL negative cell lines except for Reh cell line. Compound 9 showed lowest IC50 …

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Supramolecular Solvent-Based Microextraction For The Preconcentration Of Pb2+ Andcd2+ Prior To Spectrophotometric Detection, Huma Zafar, Faheem Shah, Rafaqat Ali Khan, Asad Muhammad Khan, Jan Nisar, Bushra Ismail Jan 2022

Supramolecular Solvent-Based Microextraction For The Preconcentration Of Pb2+ Andcd2+ Prior To Spectrophotometric Detection, Huma Zafar, Faheem Shah, Rafaqat Ali Khan, Asad Muhammad Khan, Jan Nisar, Bushra Ismail

Turkish Journal of Chemistry

Supramolecular solvent-based dispersive liquid-liquid microextraction technique has been developed as a preconcentration tool for the determination of trace level of Pb2+ and Cd2+. Dodecanol dispersed in tetrahydrofuran has been utilized as a supramolecular-solvent system for the extraction of analytes prior to their quantitative determination with graphite furnace atomic absorption spectrophotometer. Both Pb2+ and Cd2+, which were efficiently extracted by supramolecular solvent system, were complexed with dithizone followed by the addition of supramolecular solvent. The experimental variables that could possibly influence the extraction efficiency, i.e. pH value, temperature, sample volume, centrifugation time, rate of centrifugation, ionic strength, etc. were subjected to …

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Dft / Tddft Insights Into Excited State Intra-Molecular Hydrogen Atom Transfer Mechanism In Liqcoumarin: An Efp1 Study, Kandigowda Jagadeesha, Yelechakanahally Lingaraju Ramu, Mariyappa Ramegowda Jan 2022

Dft / Tddft Insights Into Excited State Intra-Molecular Hydrogen Atom Transfer Mechanism In Liqcoumarin: An Efp1 Study, Kandigowda Jagadeesha, Yelechakanahally Lingaraju Ramu, Mariyappa Ramegowda

Turkish Journal of Chemistry

The theoretical calculations were carried out on Liqcoumarin (LC) and its water complex LC+(H20)4-[LCH] at the ground (S0) / first excited states (S1) by employing density functional theory (DFT) / state specific time-dependent density functional theory (SS-TDDFT). In LC and LCH, there is an intra-molecular hydrogen bond between hydroxyl group and acetyl group along with four inter-molecular hydrogen bonds in the hydrated molecule. The computational studies of molecular structural parameters, electrostatic potential, NBO analysis, molecular orbital's, and UV-Vis spectra of both molecules under polar solvents were explored by B3LYP / 6-31G (d,p) / PCM / EFP1 method. The intra-molecular hydrogen …

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Adsorption Isotherms, Kinetic And Thermodynamic Studies On Cadmium And Lead Ions From Water Solutions Using Amberlyst 15 Resin, Adalet Tunceli̇, Abdullah Ulaş, Orhan Acar, Ali̇ Rehber Türker Jan 2022

Adsorption Isotherms, Kinetic And Thermodynamic Studies On Cadmium And Lead Ions From Water Solutions Using Amberlyst 15 Resin, Adalet Tunceli̇, Abdullah Ulaş, Orhan Acar, Ali̇ Rehber Türker

Turkish Journal of Chemistry

Adsorption isotherms, kinetic and thermodynamic parameters for Cd(II) and Pb(II) ions in water solutions by using Amberlyst 15 resin were performed and evaluated by utilizing solid phase extraction method with the batch system at 298, 308, and 318 K. Flame atomic absorption spectrometry was utilized for absorbance measurements of Cd and Pb in solutions. The Langmuir, Freundlich, and Dubinin?Radushkevich isotherm models, respectively were implemented to equilibrium results obtained. Experimental and theoretical monolayer adsorption capacities of resin for adsorptions of Cd(II) and Pb(II) by the Langmuir isotherm model were approximately the same and they were 120 and 116 mg/g for Cd(II) …

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Selective Adsorption Of Acidic Gases From Ternary Mixture By Acetate- And Sulfonate-Based Ionic Liquids At Molecular Level, Sadi̇ye Veli̇oğlu Jan 2022

Selective Adsorption Of Acidic Gases From Ternary Mixture By Acetate- And Sulfonate-Based Ionic Liquids At Molecular Level, Sadi̇ye Veli̇oğlu

Turkish Journal of Chemistry

This paper attempts to elucidate the competitive adsorption mechanism of thin films of ionic liquids (ILs) on the surface of porous materials for acidic gases at a molecular level in order to design a proper material for the diminishment of gas emissions. Thin film 1-butyl-3-methylimidazalium ([BMIM]+) cation-based IL systems composed of four different anions such as [CH3CO2]- and [CF3CO2]- (acetate-based), and [CH3SO3]- and [CF3SO3]- (sulfonate-based) are created in contact with the gas phase containing ternary H2S/CO2/CH4:1/25/74 mixture. To define gas adsorption performance at gas?liquid interface and bulk liquid phase, classical molecular dynamics simulations are carried out. Adsorption of acidic gases …

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Phytochemical Composition And Pharmacological Activities Of Teucrium Polium L. Collected From Eastern Turkey, Gi̇zem Gülsoy Toplan, Fati̇h Göger, Turgut Taşkin, Gülay Ecevi̇t Genç, Ayşe Ci̇vaş, Gökalp İşcan, Mi̇ne Kürkçüoğlu, Afi̇fe Mat, Kemal Hüsnü Can Başer Jan 2022

Phytochemical Composition And Pharmacological Activities Of Teucrium Polium L. Collected From Eastern Turkey, Gi̇zem Gülsoy Toplan, Fati̇h Göger, Turgut Taşkin, Gülay Ecevi̇t Genç, Ayşe Ci̇vaş, Gökalp İşcan, Mi̇ne Kürkçüoğlu, Afi̇fe Mat, Kemal Hüsnü Can Başer

Turkish Journal of Chemistry

Teucrium species that belong to the family Lamiaceae have been traditionally used for their medicinal properties. T. polium is one the most widespread members of the genus for its use in the treatment of several diseases. In this study, the essential oil and phenolic composition of the aerial parts from T. polium were assessed by GC-FID, GC/MS, and LC-MS/MS as well as for its total phenolic content. Several extracts such as n-hexane, chloroform, methanol, and infusion were prepared and their antimicrobial, antioxidant, and also acetylcholinesterase activities were studied. According to GC/MS results, β -caryophyllene (8.8%), t-cadinol (6.2%), (E)-nerolidol (5%), α …

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Mechanical And Wetting Properties Of Coated Paper Sheets With Varying Polydimethylsiloxane Molecular Masses In The Coating Formulation, Çağla Söz Jan 2022

Mechanical And Wetting Properties Of Coated Paper Sheets With Varying Polydimethylsiloxane Molecular Masses In The Coating Formulation, Çağla Söz

Turkish Journal of Chemistry

Coated paper sheets were prepared by immobilizing a thin coating layer of cross-linked polydimethylsiloxane (PDMS) and inorganic particles onto Whatman filter paper Grade 1 (WFP) substrates. Several coatings that differed in terms of their PDMS molecular masses were sprayed onto WFP substrates to investigate the effect of this variation on the (i) wettability and (ii) mechanical properties of the samples. Different samples having clay or silica particles in the coating formulation were investigated separately. Nonwettable coated paper sheets with promising mechanical properties were achieved and further investigated in terms of (iii) thermal resistance.

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Investigation Of Biological Activities Of Plant Extract And Green Synthesis Silvernanoparticles Obtained From Gilaburu (Viburnum Opulus L.) Fruits, Bi̇rgütay Şahi̇n, Ali̇ Savaş Bülbül, İbrahi̇m Seyfetti̇n Çeli̇k, Nesri̇n Korkmaz, Ahmet Karadağ Jan 2022

Investigation Of Biological Activities Of Plant Extract And Green Synthesis Silvernanoparticles Obtained From Gilaburu (Viburnum Opulus L.) Fruits, Bi̇rgütay Şahi̇n, Ali̇ Savaş Bülbül, İbrahi̇m Seyfetti̇n Çeli̇k, Nesri̇n Korkmaz, Ahmet Karadağ

Turkish Journal of Chemistry

In this study, biological activities of silver nanoparticles (AgNP) synthesized by green synthesis method using the fruit extract of Gilaburu (Viburnum opulus L.) plant were investigated. The characterization of the synthesized AgNPs was performed by ultraviolet visible region spectroscopy (UV-Vis), Fourier transform - infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD) techniques. The crystal size was found to be 52.32 nm when the XRD data were calculated with the Debye- Scherrer's equation. The antimicrobial activities of extract and AgNPs were investigated by microdilution and disk diffusion methods. Antibiofilm activities were examined by the crystal violet technique. The …

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Synthesis Of Benzoyl Hydrazones Having 4-Hydroxy-3,5-Dimethoxy Phenyl Ring, Theirbiological Activities, And Molecular Modeling Studies On Enzyme Inhibition Activities, Bedri̇ye Seda Kurşun Aktar, Yusuf Sicak, Gi̇zem Tatar, Emi̇ne Elçi̇n Emre Jan 2022

Synthesis Of Benzoyl Hydrazones Having 4-Hydroxy-3,5-Dimethoxy Phenyl Ring, Theirbiological Activities, And Molecular Modeling Studies On Enzyme Inhibition Activities, Bedri̇ye Seda Kurşun Aktar, Yusuf Sicak, Gi̇zem Tatar, Emi̇ne Elçi̇n Emre

Turkish Journal of Chemistry

Hydrazone compounds have high capacity in terms of antioxidant activity and enzyme inhibition activities such as anticholinesterase, tyrosinase, and urease. In this study, benzoyl hydrazones compounds (7a-7m) were synthesized starting from 3,5-dimethoxy-4-hydroxybenzaldehyde. Antioxidant activity of the synthesized compounds was evaluated. In the β-carotene-linoleic acid and ABTS cation radical scavenging activities, compounds 7j, 7e, and 7m stood out as the most active compounds, respectively. In the anticholinesterase enzyme inhibition activity results, compound 7f exhibited the best activity against AChE and BChE enzymes in the synthesis series. In addition, molecular docking analysis was performed to understand the inhibition mechanism of the synthesized …

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The Investigation Of Fluorescence And Metal Interaction Properties Of Racemic 7,8,9,10-Tetrahydro-3-Hydroxy-4-(1-Hydroxyethyl)Benzo[C]Chromen-6-One, Hayretti̇n Ozan Gülcan, Kharar Tawfeeq Shukur, Açelya Mavi̇deni̇z, Okan Si̇rkeci̇oğlu, Mustafa Gazi̇ Jan 2022

The Investigation Of Fluorescence And Metal Interaction Properties Of Racemic 7,8,9,10-Tetrahydro-3-Hydroxy-4-(1-Hydroxyethyl)Benzo[C]Chromen-6-One, Hayretti̇n Ozan Gülcan, Kharar Tawfeeq Shukur, Açelya Mavi̇deni̇z, Okan Si̇rkeci̇oğlu, Mustafa Gazi̇

Turkish Journal of Chemistry

The design or investigation of fluorescence probes continues to receive attention with respect to the diverse applications of spectrofluorometry. Depending on the highly sensitive character, fluorescence spectroscopy-based methodologies have been widely used in recent years in different sciences, including analytical, environmental, and medicinal chemistry areas. In our previous works, we have shown the iron (III) selective on-off sensor properties of benzo[c]chromen-6-one derivatives. In this study, we have extrapolated this research to 4-substituted analogues and investigated both fluorescent and metal interaction properties. Following the synthesis and structure identification studies, (±)-7,8,9,10-tetrahydro-3-hydroxy-4-(1-hydroxyethyl)benzo[c]chromen-6-one was found as a fluorescent molecule displaying fluorescence enhancement in the …

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Chromatographic Evaluation Of Tocols And Sterols Of Processed Canola Oil And Deodorizerdistillate, Hadia Shoaib, S. Tufail Sherazi, Saba Naz, Dr Sarfaraz Ahmed Mahesar, Abdul Rauf Khaskheli, Siraj Uddin, Ahmed Raza Sidhu, Hami̇de Fi̇li̇z Ayyildiz, Hüseyi̇n Kara, Mustafa Topkafa Jan 2022

Chromatographic Evaluation Of Tocols And Sterols Of Processed Canola Oil And Deodorizerdistillate, Hadia Shoaib, S. Tufail Sherazi, Saba Naz, Dr Sarfaraz Ahmed Mahesar, Abdul Rauf Khaskheli, Siraj Uddin, Ahmed Raza Sidhu, Hami̇de Fi̇li̇z Ayyildiz, Hüseyi̇n Kara, Mustafa Topkafa

Turkish Journal of Chemistry

Tocopherols and tocotrienols in the combined form are known as tocols. Changes of total and individual tocols and sterols concentration of canola oil and deodorizer distillate (DD) during different processing stages were evaluated with the application of gas chromatography (GC) and high-performance liquid chromatography (HPLC). For sterols analysis, GC coupled with flame ionization detector (FID) was used while tocols in canola oil samples and DD, normal phase (NP) HPLC was applied. The results of the present study indicated that levels of total and individual tocols and sterols content were decreased during processing (neutralization to deodorization). Deodorization was found to be …

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Effect Of Poly(Ethylene-Vinyl Acetate) Pour Point Depressant On The Cold Flow Properties And Crystallization Behavior Of Soybean Biodiesel Blends Fuel, Jinbao Liu, Chunhua Wang, Qian Liu, Fen Zhang, Xiaojie Liu, Min Sun Jan 2022

Effect Of Poly(Ethylene-Vinyl Acetate) Pour Point Depressant On The Cold Flow Properties And Crystallization Behavior Of Soybean Biodiesel Blends Fuel, Jinbao Liu, Chunhua Wang, Qian Liu, Fen Zhang, Xiaojie Liu, Min Sun

Turkish Journal of Chemistry

Although biodiesel-diesel blends are being widely used in diesel engines, investigations on its cold flow properties and crystallization behavior are still scarce. In this paper, poly(ethylene-vinyl acetate) (PEVA) pour point depressant and petroleum diesel were worked together to enhance the cold flow properties of soybean biodiesel. PEVA presented a better positive effect in reducing the cold filter plugging point (CFPP) of biodiesel blends. B40 treated with 1% PEVA exerted the best cold flow properties, and its CFPP was decreased by -14 °C. In addition, the crystallization behavior was changed variously. The sizes of crystals were decreased as well as the …

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A Simple And Rapid Rp-Hplc Method For The Assessment Of Cobalamin (Vitamin B12) Intilapia And Snoek Fishes, Labaran Ibrahim, Aminu Usman Jan 2022

A Simple And Rapid Rp-Hplc Method For The Assessment Of Cobalamin (Vitamin B12) Intilapia And Snoek Fishes, Labaran Ibrahim, Aminu Usman

Turkish Journal of Chemistry

This study developed a rapid reversed-phase high-performance liquid chromatography (RP-HPLC) method equipped with a UV-Vis detector. The aquaponics system?s tilapia and marine snoek fishes were extracted using an autoclaving process and enzymatic treatment. The technique enabled the separation and quantification of cobalamin present in these fishes extracts. Phenomenex Luna® 5 μm C18 (2) 100 A LC-column (150 × 4.6 mm) was used as a stationary phase, while the mobile phase consisted of methanol and phosphoric acid in a ratio of 35:65 (v/v), respectively. The developed method was revealed to be rapid (a retention time of less than 5.0 min), linear …

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Clerodendrum Serratum Extract Attenuates Production Of Inflammatory Mediators Inovalbumin-Induced Asthma In Rats, Poonam Arora, Shahid Hamid Ansari, Lalit Mohan Nainwal Jan 2022

Clerodendrum Serratum Extract Attenuates Production Of Inflammatory Mediators Inovalbumin-Induced Asthma In Rats, Poonam Arora, Shahid Hamid Ansari, Lalit Mohan Nainwal

Turkish Journal of Chemistry

In the present study, ethanolic extract of Clerodendrum serratum roots was investigated for its potential to reverse some features of bronchial asthma in ovalbumin-induced murine model of asthma. Clerodendrum serratum commonly called bharangi, (family Solanaceae) is a well-known anti-allergic drug in Asian folk system of medicines. In the present work, pharmacological studies are done to provide scientific evidence for therapeutic potential of plant in allergic asthma. Asthma was induced in experimental rats with allergen suspension of ovalbumin and aluminum hydroxide followed by treatment with dexamethasone (2.5 mg/kg, po) or C. serratum root extract (0.53 and 5.3 mg/kg, b. w., po). …

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Algaecidal And Oxidative Effects Of Metal-Free Phthalocyanine Beta Tetra-Substituted With Sodium 2-Mercaptoethanesulfonate, Hati̇ce Tunca, Sena Çağatay Özpinar, Ayşe Gül Tekbaba, Tuğba Ongun Sevi̇ndi̇k, Ali̇ True, Armağan Günsel, Ahmet Turgut Bi̇lgi̇çli̇, Meryem Ni̇lüfer Yaraşir Jan 2022

Algaecidal And Oxidative Effects Of Metal-Free Phthalocyanine Beta Tetra-Substituted With Sodium 2-Mercaptoethanesulfonate, Hati̇ce Tunca, Sena Çağatay Özpinar, Ayşe Gül Tekbaba, Tuğba Ongun Sevi̇ndi̇k, Ali̇ True, Armağan Günsel, Ahmet Turgut Bi̇lgi̇çli̇, Meryem Ni̇lüfer Yaraşir

Turkish Journal of Chemistry

In this study, a water-soluble metal-free phthalocyanine (SPC) containing sodium 2-mercaptoethanesulfonate substituents at the peripheral positions was used to investigate the algaecidal properties and oxidative effects on the growth of two microalgal species, Arthrospira platensis and Chlorella vulgaris. Although OD at 560 nm and chlorophyll-a content were decreased in Arthrospira platensis during 7 days depending on dose and time, increases in both OD at 750 and chlorophyll-a content at 8 ppb (parts per billion) concentration on the 7th day were observed in Chlorella vulgaris. However, total SOD (superoxide dismutase) and GR (glutathione reductase) enzyme activity of A. platensis cultures did …

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In Situ Prepared Tungsten(Vi) Oxide Supported Pd0 Nps, Remarkable Activity Andreusability In H2 Releasing From Dimethylamine Borane, Seda Karaboğa Jan 2022

In Situ Prepared Tungsten(Vi) Oxide Supported Pd0 Nps, Remarkable Activity Andreusability In H2 Releasing From Dimethylamine Borane, Seda Karaboğa

Turkish Journal of Chemistry

The study reports preparation, characterization, and catalytic activity of Pd0/WO3 nanoparticles in H2 evolution from dimethylamine borane (DMAB). The active catalyst called Pd0/WO3 NPs were obtained from the in situ reduction of Pd2+/WO3 precatalyst and tested in H2 releasing from DMAB. Pd0/WO3 NPs were found as remarkable catalysts providing a turnover frequency value of 948.0 h-1 in H2 releasing from DMAB at 60.0 ± 0.5 °C. The results of some advanced analytical techniques reveal that Pd0 NPs show uniform dispersion on the surface of tungsten(VI) oxide (WO3) with 5.85 ± 0.57 nm of particle size. The reducible nature of tungsten(VI) …

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Schiff Base Functionalized Silica Gel For Simultaneous Separation And Preconcentration Of Cu(Ii), Ni(Ii), And Cd(Ii) In Pharmaceuticals And Water Samples, Feyzullah Tokay, Sema Bağdat Jan 2022

Schiff Base Functionalized Silica Gel For Simultaneous Separation And Preconcentration Of Cu(Ii), Ni(Ii), And Cd(Ii) In Pharmaceuticals And Water Samples, Feyzullah Tokay, Sema Bağdat

Turkish Journal of Chemistry

A method for separation and preconcentration of Cu(II), Ni(II), and Cd(II) using N-N'-bis(5-methoxsalicylidene)-2-hydroxy-1,3-propanediamine modified silica gel was improved for aqueous samples and pharmaceuticals. Determination of the analytes was achieved by inductively coupled plasma optic emission spectrometry. The experimental conditions including pH value, sample volume, eluent type and volume, sorbent mass, sample, and eluent flow rates were optimized with univariate and multivariate optimization tools. The relative standard deviations of the method were 2.9% for Cu(II), 3.0% for Ni(II), and 3.3% for Cd(II) with recovery values between 98.8 ± 3.2-101.5 ± 3.0%. The limits of detection were found to be 62.4, 39.5, …

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Selective Catalytic Hydrogenation Of Cellulose Into Sorbitol With Ru-Based Catalysts, Ceren Orak, Aycan Sapmaz, Asli Yüksel Özşen Jan 2022

Selective Catalytic Hydrogenation Of Cellulose Into Sorbitol With Ru-Based Catalysts, Ceren Orak, Aycan Sapmaz, Asli Yüksel Özşen

Turkish Journal of Chemistry

Sorbitol is one of the platform chemicals and can be produced from various renewable and sustainable sources via different processes. Hydrothermal liquefaction is an effective and promising approach to produce sorbitol, since the subcritical reaction media and appropriate catalysts provide a selective production of platform chemicals. In this study, sorbitol was produced from different renewable sources (cellulose and glucose) in the presence of Ru-based catalysts (Ru/SiO2, Ru/AC, Ru/SBA-15, and Ru/SBA-15-SO3) under subcritical conditions. The highest cellulose conversion was achieved as 90% in the presence of Ru/SBA-15-SO3 for 1 h of reaction duration. The highest sorbitol yield (%) by hydrothermal liquefaction …

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Study On The Alkylation Of Aromatic Hydrocarbons And Propylene, Wanglai Dong, Wentao Ma, Xinyao Li, Xingbang Hu, Zheng Zhou Jan 2022

Study On The Alkylation Of Aromatic Hydrocarbons And Propylene, Wanglai Dong, Wentao Ma, Xinyao Li, Xingbang Hu, Zheng Zhou

Turkish Journal of Chemistry

In order to improve the efficiency of the alkylation reaction to aromatic hydrocarbons and propylene, different types of catalysts were screened, including ultra-stable Y molecular sieves (USY), solid phosphoric acid (SPA), ZSM type molecular sieve (HZSM), etc. The effects of reaction temperature, catalyst loading, and reaction time on the conversion rate of aromatic hydrocarbons and the selectivity of target products were investigated using the high-pressure reaction device. The catalysts were characterized by XRD, BET, SEM, FT-IR, NH3-TPD, and other methods. The experimental results show that the USY catalyst exhibits higher catalytic activity for alkylation. This catalyst can be used for …

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Bovine Serum Albumin Detection By Using Molecularly Imprinted Surface Plasmon Resonance Sensors, Ali̇ Araz Jan 2022

Bovine Serum Albumin Detection By Using Molecularly Imprinted Surface Plasmon Resonance Sensors, Ali̇ Araz

Turkish Journal of Chemistry

Molecular imprinted polymers (MIP) have key-lock pattern binding properties specific to the size and shape of target molecules. In this study, we have prepared detection platforms based on a molecularly imprinted surface plasmon resonance (SPR) sensor that can detect bovine serum albumin (BSA) sensitively, selectively, quickly, and in real time. The polymeric film prepared on the SPR sensor surface by molecular imprinting method was obtained by selecting the N-methacryloyl-(L)-glutamic acid molecule as a suitable functional monomer using ultraviolet polymerization. Three different imprinting methods, such as epitope, bulk, and surface imprinting methods, were used to examine the imprinting efficiency. Real-time measurements …

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A Bodipy Based Probe For The Reversible "Turn On" Detection Of Au(Iii) Ions, Muhammed Üçüncü Jan 2022

A Bodipy Based Probe For The Reversible "Turn On" Detection Of Au(Iii) Ions, Muhammed Üçüncü

Turkish Journal of Chemistry

A new "turn on" fluorescent probe for the rapid and selective detection of Au3+ ions over other metal ions was developed. The probe design was constructed on a BODIPY-2-aminopyridine skeleton showing a weak fluorescence emission signal which increased substantially after the coordination of Au3+ ions. The probe displayed remarkable sensing performances such as a low limit of detection (17 nM), a short response time (

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New Bis-Isoxazole With Monoterpenic Skeleton: Regioselective Synthesis, Spectroscopicinvestigation, Electrochemical, And Density Functional Theory (Dft) Studies, Ali Oubella, Meryem Hrimla, Mouhi Eddine Hachim, Mourad Fawzi, Abdoullah Bimoussa, Lahoucine Bahsis, Aziz Boutouil, Aziz Auhmani, Abdelkhalek Riahi, My Youssef Ait Itto Jan 2022

New Bis-Isoxazole With Monoterpenic Skeleton: Regioselective Synthesis, Spectroscopicinvestigation, Electrochemical, And Density Functional Theory (Dft) Studies, Ali Oubella, Meryem Hrimla, Mouhi Eddine Hachim, Mourad Fawzi, Abdoullah Bimoussa, Lahoucine Bahsis, Aziz Boutouil, Aziz Auhmani, Abdelkhalek Riahi, My Youssef Ait Itto

Turkish Journal of Chemistry

A novel bis-isoxazole was synthesized from (R)-Carvone and p-methylbenzaldoxime, via two successive [3+2] cycloaddition reactions (32CA). The newly obtained bis-isoxazole has been fully characterized by HRMS and NMR spectroscopy. The HMBC experiment was performed to determine the stereo and the regioselectivity of the reaction. The electrochemical behavior of the studied compound, in oxidation and reduction processes, was examined using the cyclic voltammetry technique. In addition, the regioselectivity of the [3+2] cycloaddition reaction and the molecular structure of the title compound was performed by density functional theory (DFT). The HOMO and LUMO orbitals were investigated to determine the electronic properties of …

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Investigation Of The Oxygen Reduction Kinetics And Mechanism On Ordered Mesoporouscarbon-Supported Pt-Based Catalysts, Si̇lver Güneş, Fatma Çi̇ğdem Güldür Jan 2022

Investigation Of The Oxygen Reduction Kinetics And Mechanism On Ordered Mesoporouscarbon-Supported Pt-Based Catalysts, Si̇lver Güneş, Fatma Çi̇ğdem Güldür

Turkish Journal of Chemistry

The kinetics and mechanism of oxygen reduction reaction (ORR) on the surface of Pt and PtAgFe catalysts supported by ordered mesoporous carbon (OMC) were investigated. Metal particles were loaded by the wet impregnation-reduction method on two types of OMC, one being surface-modified by HNO3 and the other unmodified. Cyclic voltammetry measurements showed that Pt on modified OMC, namely Pt/OMC-M, had the highest electroactive surface area among OMC-supported catalyts with 987 cm2/mg. This catalyst had also a mass activity of 39.1 mA/mgPt, which was the same as the carbon black supported commercial Pt/C catalyst. Rotating disk electrode (RDE) studies revealed that …

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Preconcentration Of Trace Amount Cu(Ii) By Solid-Phase Extraction Method Usingactivated Carbon-Based Ion-Imprinted Sorbent, Kübra Turan, Ruki̇ye Saygili Canlidi̇nç, Orhan Murat Kalfa Jan 2022

Preconcentration Of Trace Amount Cu(Ii) By Solid-Phase Extraction Method Usingactivated Carbon-Based Ion-Imprinted Sorbent, Kübra Turan, Ruki̇ye Saygili Canlidi̇nç, Orhan Murat Kalfa

Turkish Journal of Chemistry

In this study, preconcentration conditions of trace amounts of copper ions were investigated with solid-phase extraction (SPE) method by synthesizing activated carbon-based ion-imprinted sorbent (Cu(II)-IAC) with a novel and selective approach. Flame atomic absorption spectrometry (FAAS) was used for the determination of metal ions concentrations. For the characterization of the sorbents, scanning electron microscopy, energy dispersive X-ray (SEM/EDX) analysis, and Fourier transform infrared spectroscopy (FTIR) were used. Optimum conditions for the SPE procedure, various parameters such as pH value, eluent type and concentration, sample volume, sample flow rate, adsorption capacity, and selectivity were studied. The adsorption isotherm was analyzed by …

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Development Of Dual Enzyme Responsive Molecular And Logic Gate, Sündüs Erbaş Çakmak Jan 2022

Development Of Dual Enzyme Responsive Molecular And Logic Gate, Sündüs Erbaş Çakmak

Turkish Journal of Chemistry

Molecular logic gates are information processing devices that can respond to environmental signals and produce a readable output in response through Boolean logic operations. Molecules with these properties have been used to build smart sensors and therapeutic agents. In this work, dual enzyme-responsive molecular AND logic gate is developed with the intention to discriminate various combinations of enzyme level and/or activity. A resorufin-based sensor is substituted with self-immolative tyrosinase recognition site, 3-hydroxy benzyl group. The Hydroxyl group is protected with acetyl moiety which decreases the affinity of the enzyme. When both tyrosinase and esterase are present in the solution, the …

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Determination Of Formaldehyde In Textile Dye And Auxiliary Chemicals With Headspace Gas Chromatography-Flame Ionization Detector, Korel Güneş, Zi̇ya Can, Ayşem Arda Jan 2022

Determination Of Formaldehyde In Textile Dye And Auxiliary Chemicals With Headspace Gas Chromatography-Flame Ionization Detector, Korel Güneş, Zi̇ya Can, Ayşem Arda

Turkish Journal of Chemistry

Formaldehyde is a chemical used in many different industrial sectors and is classified as a carcinogen as well as causing allergic reactions. Due to the health effects of formaldehyde, which is widely used in textile dyes and auxiliary chemicals, its analysis in this type of matrices becomes important. In this study, in order to meet these requirements, formaldehyde was converted to oxime derivative by derivatization with o-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride. This derivative was successfully sampled with the headspace technique and analyzed with a gas chromatography-flame ionization detector (GC-FID). For the developed method, derivatization and salt effect parameters were investigated. For the method, …

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Synthesis, Predictions Of Drug-Likeness, And Pharmacokinetic Properties Of Some Chiral Thioureas As Potent Enzyme Inhibition Agents, Yusuf Sicak Jan 2022

Synthesis, Predictions Of Drug-Likeness, And Pharmacokinetic Properties Of Some Chiral Thioureas As Potent Enzyme Inhibition Agents, Yusuf Sicak

Turkish Journal of Chemistry

A series of chiral thioureas (1 - 17) were synthesized from and tested for their anticholinesterase, tyrosinase, and urease enzyme inhibitor activities. Various phenylisothiocyanates were added to solution of L-cysteine in methanol: water (1 : 1 v / v) at room temperature and stirred for 24 h. The precipitated solid was recrystallized from n-butanol. Pure compounds were characterized by NMR (1H and 13C), FTIR, and CHNS. Tertiary amine containing N-(4-(diethylamino)phenyl)-N'-(2-mercapto-carboxyethanyl)thiourea 17, N-(4-(dimethylamino)phenyl)-N'-(2-mercapto-carboxyethanyl)thiourea 16 and trimethoxy containing N-(3,4,5-trimethoxyphenyl)-N'-(2-mercapto-carboxyethanyl)thiourea 14 were more active than galantamine against AChE and BChE enzymes. In tyrosinase enzyme inhibition activity, compound 14, 10, 12, 6, 13, and …

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Selective Hydrogenation Of Diphenylacetylene Using Nico Nanoparticles Supported On Mesoporous Carbon As Catalyst, Alyaa Shiddiqah, Iman Abdullah, Yuni Krisnandi Jan 2022

Selective Hydrogenation Of Diphenylacetylene Using Nico Nanoparticles Supported On Mesoporous Carbon As Catalyst, Alyaa Shiddiqah, Iman Abdullah, Yuni Krisnandi

Turkish Journal of Chemistry

Hydrogenation of alkynes to alkenes is an important procedure in the synthesis of organic compounds. In this study, selective hydrogenation was carried out on diphenylacetylene as a model of alkyne compounds using NaBH4 as a hydrogen source and NiCo bimetallic nanoparticles supported on mesoporous carbon (NiCo/MC) as a catalyst. The mesoporous carbon was prepared using the soft-templated method from phloroglucinol and formaldehyde as precursors while the NiCo/MC catalyst was synthesized using a wet impregnation method. Based on surface area analysis, it was found that the pore diameters of MC, Ni/MC, and NiCo/MC were 12.8 nm, 13.4 nm, and 12.7 nm …

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A Systematic Review Of Rdrp Of Sars-Cov-2 Through Artificial Intelligence And Machine Learning Utilizing Structure-Based Drug Design Strategy, Fariha Imtiaz, Mustafa Kamal Pasha Jan 2022

A Systematic Review Of Rdrp Of Sars-Cov-2 Through Artificial Intelligence And Machine Learning Utilizing Structure-Based Drug Design Strategy, Fariha Imtiaz, Mustafa Kamal Pasha

Turkish Journal of Chemistry

Since the coronavirus disease has been declared a global pandemic, it had posed a challenge among researchers and raised common awareness and collaborative efforts towards finding the solution. Caused by severe acute respiratory coronavirus syndrome-2 (SARS-CoV-2), coronavirus drug design strategy needs to be optimized. It is understandable that cognizance of the pathobiology of COVID-19 can help scientists in the development and discovery of therapeutically effective antiviral drugs by elucidating the unknown viral pathways and structures. Considering the role of artificial intelligence and machine learning with its advancements in the field of science, it is rational to use these methods which …

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Computational Investigation Of Unsaturated Ketone Derivatives As Mao-B Inhibitors By Using Qsar, Adme/Tox, Molecular Docking, And Molecular Dynamics Simulations, Abdellah El Aissouq, Mohammed Bouachrine, Abdelkrim Ouammou, Fouad Khalil Jan 2022

Computational Investigation Of Unsaturated Ketone Derivatives As Mao-B Inhibitors By Using Qsar, Adme/Tox, Molecular Docking, And Molecular Dynamics Simulations, Abdellah El Aissouq, Mohammed Bouachrine, Abdelkrim Ouammou, Fouad Khalil

Turkish Journal of Chemistry

Unsaturated ketone derivatives are known as monoamine oxidase B (MAO-B) inhibitors, a potential drug target for Parkinson?s disease. Here, molecular modeling studies, including 2D-QSAR, ADMET prediction, molecular docking, and MD simulation, were performed on a new series of MAO-B inhibitors. The objective is to identify new MAO-B inhibitors with high inhibitory efficacy. The developed 2D-QSAR model was based on the descriptors of MOE software. The most appropriate model, using the partial least squares regression (PLS regression) method, yielded 0.88 for the determination coefficient (r2), 0.28 for the root-mean-square error (RMSE), and 0.2 for the mean absolute error (MAE). The predictive …

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