Digital Commons Network^™

Mucus-Degrading Bacteroides Link Carbapenems To Aggravated Graft-Versus-Host Disease, Eiko Hayase, Tomo Hayase, Mohamed A Jamal, Takahiko Miyama, Chia-Chi Chang, Miriam R Ortega, Saira S Ahmed, Jennifer L Karmouch, Christopher A Sanchez, Alexandria N Brown, Rawan K El-Himri, Ivonne I Flores, Lauren K Mcdaniel, Dung Pham, Taylor Halsey, Annette C Frenk, Valerie A Chapa, Brooke E Heckel, Yimei Jin, Wen-Bin Tsai, Rishika Prasad, Lin Tan, Lucas Veillon, Nadim J Ajami, Jennifer A Wargo, Jessica Galloway-Peña, Samuel Shelburne, Roy F Chemaly, Lauren Davey, Robert W P Glowacki, Chen Liu, Gabriela Rondon, Amin M Alousi, Jeffrey J Molldrem, Richard E Champlin, Elizabeth J Shpall, Raphael H Valdivia, Eric C Martens, Philip L Lorenzi, Robert R Jenq

Faculty, Staff and Student Publications

The intestinal microbiota is an important modulator of graft-versus-host disease (GVHD), which often complicates allogeneic hematopoietic stem cell transplantation (allo-HSCT). Broad-spectrum antibiotics such as carbapenems increase the risk for intestinal GVHD, but mechanisms are not well understood. In this study, we found that treatment with meropenem, a commonly used carbapenem, aggravates colonic GVHD in mice via the expansion of Bacteroides thetaiotaomicron (BT). BT has a broad ability to degrade dietary polysaccharides and host mucin glycans. BT in meropenem-treated allogeneic mice demonstrated upregulated expression of enzymes involved in the degradation of mucin glycans. These mice also had thinning of the colonic …

We Are ... Marshall, September 28, 2022, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Effects Of Early‑Life Experience On Innovation And Problem‑Solving In Captive Coyotes, Andrew C. Garcia, Mitchell A. Parsons, Julie K. Young

United States Department of Agriculture Wildlife Services: Staff Publications

Early-life experience often shapes behaviors like innovation and exploration. These behaviors are important to animals encountering novel food resources in diverse habitats, such as mesocarnivores in urban areas. To understand if early-life experiences impact later-life behavior, we examined how coyotes (Canis latrans) responded to a multi-access puzzle box at two life stages: pup (~ 7 weeks) and dispersal (~ 10 months). We first exposed pups, still living with their parents and littermates, to a baited puzzle box. At dispersal age, we again tested both these pups and an age-matched control group that was not exposed to the puzzle …

Covid-19 Newsletter (Vol. 138), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

The Ecology And Epidemiology Of Malaria Parasitism In Wild Chimpanzee Reservoirs, Erik J. Scully, Weimin Liu, Yingying Li, Jean-Bosco N. Ndjango, Martine Peeters, Shadrack Kamenya, Anne E. Pusey, Elizabeth V. Lonsdorf, Crickette M. Sanz, David B. Morgan, Alex K. Piel, Fiona A. Stewart, Mary K. Gonder, Nicole Simmons, Caroline Asiimwe, Klaus Zuberbuehler, Kathelijne Koops, Colin A. Chapman, Rebecca Chancellor, Aaron S. Rundus, Michael A. Huffman, Nathan D. Wolfe, Manoj T. Duraisingh, Beatrice H. Hahn, Richard W. Wrangham

Anthropology & Sociology Faculty Publications

Chimpanzees (Pan troglodytes) harbor rich assemblages of malaria parasites, including three species closely related to P. falciparum (sub-genus Laverania), the most malignant human malaria parasite. Here, we characterize the ecology and epidemiology of malaria infection in wild chimpanzee reservoirs. We used molecular assays to screen chimpanzee fecal samples, collected longitudinally and cross-sectionally from wild populations, for malaria parasite mitochondrial DNA. We found that chimpanzee malaria parasitism has an early age of onset and varies seasonally in prevalence. A subset of samples revealed Hepatocystis mitochondrial DNA, with phylogenetic analyses suggesting that Hepatocystis appears to cross species barriers more easily than Laverania. …

Transmission Roles Of Symptomatic And Asymptomatic Covid-19 Cases: A Modelling Study, Jianbin Tan, Yang Ge, Leonardo Martinez, Jimin Sun, Changwei Li, Adrianna Westbrook, Enfu Chen, Jinren Pan, Yang Li, Wei Cheng, Feng Ling, Zhinping Chen, Ye Shen, Hui Huang

Faculty Publications

Coronavirus disease 2019 (COVID-19) asymptomatic cases are hard to identify, impeding transmissibility estimation. The value of COVID-19 transmissibility is worth further elucidation for key assumptions in further modelling studies. Through a population-based surveillance network, we collected data on 1342 confirmed cases with a 90-days follow-up for all asymptomatic cases. An age-stratified compartmental model containing contact information was built to estimate the transmissibility of symptomatic and asymptomatic COVID-19 cases. The difference in transmissibility of a symptomatic and asymptomatic case depended on age and was most distinct for the middle-age groups. The asymptomatic cases had a 66.7% lower transmissibility rate than symptomatic …

Recent Emergence Of Bovine Coronavirus Variants With Mutations In The Hemagglutinin-Esterase Receptor Binding Domain In U.S. Cattle, Aspen M. Workman, Tara G. Mcdaneld, Gregory P. Harhay, Subha Das, John Dustin Loy, Benjamin M. Hause

School of Veterinary and Biomedical Sciences: Faculty Publications

Bovine coronavirus (BCoV) has spilled over to many species, including humans, where the host range variant coronavirus OC43 is endemic. The balance of the opposing activities of the surface spike (S) and hemagglutinin-esterase (HE) glycoproteins controls BCoV avidity, which is critical for interspecies transmission and host adaptation. Here, 78 genomes were sequenced directly from clinical samples collected between 2013 and 2022 from cattle in 12 states, primarily in the Midwestern U.S. Relatively little genetic diversity was observed, with genomes having >98% nucleotide identity. Eleven isolates collected between 2020 and 2022 from four states (Nebraska, Colorado, California, and Wisconsin) contained a …

Recent Emergence Of Bovine Coronavirus Variants With Mutations In The Hemagglutinin-Esterase Receptor Binding Domain In U.S. Cattle, Aspen M. Workman, Tara G. Mcdaneld, Gregory P. Harhay, Subha Das, John Dustin Loy, Benjamin M. Hause

School of Veterinary and Biomedical Sciences: Faculty Publications

Bovine coronavirus (BCoV) has spilled over to many species, including humans, where the host range variant coronavirus OC43 is endemic. The balance of the opposing activities of the surface spike (S) and hemagglutinin-esterase (HE) glycoproteins controls BCoV avidity, which is critical for interspecies transmission and host adaptation. Here, 78 genomes were sequenced directly from clinical samples collected between 2013 and 2022 from cattle in 12 states, primarily in the Midwestern U.S. Relatively little genetic diversity was observed, with genomes having >98% nucleotide identity. Eleven isolates collected between 2020 and 2022 from four states (Nebraska, Colorado, California, and Wisconsin) contained a …

The Lived Social Experience Of Covid-19 Survivors In Southwestern Nigeria, Endurance Uzobo, Ijeoma Nwanwene, Tolulope Funmilola Ojo

Journal of Social, Behavioral, and Health Sciences

The traditional perceptions of disease causation often reinforce the feelings of stigmatization and discrimination towards individuals who have recovered from an illness. This study investigated the existing social practices with regard to stigmatization and discrimination against COVID-19 survivors in Southwest Nigeria. Using the Psychoanalytic Theory, this phenomenological qualitative study utilized the snowball sampling method and an in-depth interview to sample 25 COVID-19 survivors in Southwest Nigeria. Collected data for this study were analyzed thematically, using content analysis with the aid of the ATLAS.ti software. Findings from the study indicated that COVID-19 survivors generally experience sympathy, hostility, mockery, and social exclusion. …

Attitudes Toward Covid-19 And Covid-19 Vaccinations Among Athletic Trainers, Stephen A. Cage, Paul Mcgaha, Monica Matocha, Michelle Crum, Phd, Cathy Fieseler, Laurel Trail, Brandon J. Warner, Diana M. Gallegos

Internet Journal of Allied Health Sciences and Practice

Purpose: Following the beginning of the pandemic brought about by the novel coronavirus which causes COVID-19, the first COVID-19 vaccination received emergency use authorization in the United States of America in December of 2020. Current research has shown the authorized COVID-19 vaccines are safe and effective at preventing severe illness, hospitalizations and death have a good safety profile. Additionally, the side effects associated with these vaccines are typically mild to moderate while the protection against hospitalization and severe disease is substantial. (https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/adverse-events.html). At the time of this study, there appears to be a paucity in the research related …

Do You Know The Pathophysiology Of Cytokine Storm During Covid-19?, Shameera Shaik Masthan, Deekshitha Turaka, Ahmed Abdelhaleem, Mounica Vorla, Steven B. Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Green Synthesis Of Silver Nanoparticles From Diospyros Villosa Extracts And Evaluation Of Antioxidant, Antimicrobial And Anti-Quorum Sensing Potential, Ot Adu, Farzana Mohamed, Yougasphree Naidoo, Ts Adu, Hafizah Chenia, Yaser Hassan Dewir, Hail Rihan

School of Biological and Marine Sciences

The biosynthesis of silver nanoparticles (AgNPs) from Diospyros villosa leaves and stem bark extracts is described. The stem bark AgNPs of D. villosa synthesized at 80 °C (S80) showed good scavenging activity with a lower IC50 value of 8.75 µg·mL−1 compared to ascorbic acid (9.58 µg·mL−1). The total phenol content of the S80 AgNPs was measured and found to be 10.22 ± 0.14 mg.g−1 gallic acid equivalence (GAE). Bacterial growth inhibition (% GI) and violacein inhibition (% VI) of 10.08% and 58.83%, respectively, was observed against C.subtsugae CV017 with leaf AgNPs synthesized at 80 °C (L80) at 80 μg·mL−1. Stem …

The Development And Growth Of Cardio-Oncology Or Onco-Cardiology, Bernard Man Yung Cheung, Chu Pak Lau

Journal of the Hong Kong College of Cardiology

No abstract provided.

A New Method For Cluster Life Cycle Stage Identification: Mapping The Evolution Of The Biomedical Competitiveness Cluster Of Wallonia., Conor Michael Harte

Theses

National governments and policy makers alike need data and expertise as they seek to develop accurate and relevant cluster policies and initiatives. It is argued that clusters also have life cycles similar to the way industries, products, and technologies have a life cycle, including a variety of stages (Ingstrup and Damgaard, 2013; Jia et al., 2015; Fornahl and Hassink, 2017; Ferrari et al., 2020). This research addresses three objectives: 1. Analyse the longitudinal development of a cluster to record, measure and analyse its evolution over a three-year period; 2. Create a new methodology to support cluster life cycle stage identification; …

Sterile Setup Table In The Operating Room Is Not So Sterile, Farideh Najafi, Diana Fernández-Rodríguez, Javad Parvizi

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: One of the important factors for surgical site infection prevention is the implementation of an ultraclean operating room. This study was designed to evaluate back-table sterility during total joint arthroplasty.

METHODS: This prospective study includes 52 patients undergoing primary total joint arthroplasty between November 2021 and January 2022. A total of 4 swabs (2 air swabs and 2 table swabs) were obtained for each case, at the conclusion of surgery and prior to the takedown of drapes. One swab from each set was sent for culture, and the other was sent for next-generation sequencing (NGS) analysis.

RESULTS: Among 104 …

Electrochemical Biosensing And Deep Learning-Based Approaches In The Diagnosis Of Covid-19: A Review, Omer Sadak, Ferhat Sadak, Ozal Yildirim, Nicole M. Iverson, Rizwan Qureshi, Muhammed Talo, Chui Ping Ooi, U. Rajendra Acharya, Sundaram Gunasekaran, Tanvir Alam

Department of Agricultural and Biological Systems Engineering: Faculty Publications

COVID-19 caused by the transmission of SARS-CoV-2 virus taking a huge toll on global health and caused life-threatening medical complications and elevated mortality rates, especially among older adults and people with existing morbidity. Current evidence suggests that the virus spreads primarily through respiratory droplets emitted by infected persons when breathing, coughing, sneezing, or speaking. These droplets can reach another person through their mouth, nose, or eyes, resulting in infection. The "gold standard'' for clinical diagnosis of SARS-CoV-2 is the laboratory-based nucleic acid amplification test, which includes the reverse transcription-polymerase chain reaction (RT-PCR) test on nasopharyngeal swab samples. The main concerns …

Chronic Illness Education 2022: Raising Awareness About Perinatal Hiv Transmission Risks And Preventions, Muhammad Ahmed, Emma Streveler, John Lloyd, Joseph Cavataio, Mackenzie Howard, Riya Shah, Rooshan Arshad

Patient Education Projects

No abstract provided.

Chronic Illness Education 2022: Increasing Hiv Knowledge And Awareness Of The Young Adult Population In The Local Detroit Community, Rachel Monconduit, Catherine Bogolawski, Haniyeh Zamani, Joshua Kirschner, Logan Thayer, Matthew Corsi, Samantha Pfiffner

Patient Education Projects

No abstract provided.

Implementation Of An E-Learning Module To Increase Rn Knowledge And Skills Of Emergency Preparedness, Kaitlyn Hope Chung

Doctor of Nursing Practice Projects

Background

By failing to prepare, you are preparing to fail. —Benjamin Franklin, writer, philosopher, politician. Having education initiatives for mass casualty incidents and disaster preparedness that are concise and organized is of high importance. This issue is pertinent to the midwestern medical center where this project took place because in the event of a true mass casualty or disaster scenario, many lives could be saved if registered nurses (RNs) in the emergency department (ED) were better prepared. For a hospital to provide adequate and effective care during a crisis, healthcare workers must be effectively trained to do so. However, many …

Impact Of Skeletal Muscle Loss During Conversion Therapy On Clinical Outcomes In Lavage Cytology Positive Patients With Gastric Cancer, Ping'an Ding, Peigang Yang, Li Yang, Chenyu Sun, Shuya Chen, Min Li, Scott Lowe, Honghai Guo, Yuan Tian, Yang Liu, Qun Zhao

Student Publications

Background: The relationship between sarcopenia and clinical outcomes during conversion therapy in patients with lavage cytology positive gastric cancer (GC-CY1) remains unclear. This study aimed to investigate the impact of sarcopenia and skeletal muscle loss on the efficacy of conversion therapy, tumour response and survival in GC-CY1 patients.

Methods: Retrospective analysis of data from a prospective trial of conversion therapy conducted between April 2018 and August 2019 in patients with GC-CY1 (NCT03718624). Skeletal muscle index (SMI) was measured at the level of the third lumbar (L3) vertebra and the sarcopenia was defined using published cut-off points in all …

Autoaggregation Ability Of Diarrheal Causative Bacteria Isolated From Iraqi Children, Shahad Rashad Hameed

Muthanna Medical Journal

Stool samples were collected from 100 children patient aged between 3 days to 11 years who suffered from diarrhoea to isolate diarrheal causative bacteria. Fifty-one isolates were isolated and identified by cultural, microscopical, biochemical tests, and Vitek 2 system. The isolates were distributed as: 46 isolates belonged to Escherichia coli, 4 isolates belonged to Shigella sonnei, and one isolate belonged to Providencia alcalifaciens. All isolates were tested for antibiotic susceptibility to 10 different antibiotics and autoaggregation ability. All isolates were revealed resistant to Metronidazole while they were sensitive to Imipenem except one isolate of E. coli showed resistance to it. …

International Migrants And Coronavirus Disease 2019 Vaccinations: Social Media, Motivated Information Management, And Vaccination Willingness, Hyunjin Seo, Yuchen Liu, Muhammad Ittefaq, Fatemeh Shayesteh, Ursula Kamanga, Annalise Baines

School of Communication Studies - Faculty Scholarship

Objective

This study examines how those who were born outside the United States and migrated to the country in the past decade used social media and other online sites to deal with uncertainties around the coronavirus disease 2019 pandemic. In particular, we examine how they used digital communication technologies to tap into online resources and social connections both in the United States and their origin country and how various aspects of online information management were associated with their willingness to get vaccinated against the virus.

Method

We conducted an online survey and in-depth interviews with international migrants aged 18–64 years …

Aggforclus: A Hybrid Methodology Integrating Forecasting With Clustering To Assess Mitigation Plans And Contagion Risk In Pandemic Outbreaks: The Covid-19 Case Study, Milton Soto-Ferrari, Alejandro Carrasco-Pena, Diana Prieto

Faculty Research Articles

The COVID-19 pandemic showed governments’ unpreparedness as decision-makers hastily created restrictions and policies to contain its spread. Identifying prospective areas with a higher contagion risk can reduce mitigation planning uncertainty. This research proposes a risk assessment metric called AGGFORCLUS that integrates time-series forecasting and clustering to convey joint information on predicted caseload growth and variability, thereby providing an educated yet visually simple view of the risk status. In AGGFORCLUS, the development is sectioned into three phases. Phase I forecasts confirmed cases using a mixture of five different forecasting methods. Phase II develops the identified best model forecasts for an extended …

2022 Btl O&M Events Log, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Endemic Diseases In Samawah District 1958-1968, Sanaa Munshid Stupid Al-Jiyashi, Tired Khalaf Jaber Al-Rishawi

Uruk Journal of Human Sciences

Infectious diseases still have far-reaching effects on people's lives. In some poor cities, diseases continue to destroy economies and disable health systems. From the beginning, social and economic barriers, as well as the atrophy of people's health culture, helped spread diseases, and among those major diseases that spread during that period: Schistosomiasis And malaria, ancylostoma, trachoma, smallpox, It contributed to the loss of many lives of the people of Samawah district, And the relentless attempts of health units to neutralize those diseases.

September 22, 2022, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

An Assessment Model Of The Healthcare Entrepreneurship Ecosystem To Foster Solutions For Underserved Communities, Abdalilah Saleh Owaishiz

Dissertations and Theses

There are significant disparities in access to healthcare treatment and this study investigates the healthcare entrepreneurship ecosystem and the challenges and considerations associated within. There is a lack of research on how to evaluate and assess the healthcare entrepreneurship ecosystem especially when applying multi-criteria decision-making (MCDM) methods. The Hierarchical Decision Model (HDM) has been utilized to identify several perspectives and factors grouped under them by the expert’s quantification. This research concentrates on underserved communities because that is where the biggest needs and impact can be made to support achieving health equity and universal health coverage. The findings of this research …

Wastewater-Informed Public Health Intervention Playbook

Sustain Magazine

As the SARS-CoV-2 pandemic quickly spread from country to country and continent to continent in 2020, governments and scientists needed a way to track COVID-19 through populations in order to position public health interventions in the most impactful locations. Having a decision-based risk framework may help to guide policy creation that could minimize or prevent possible outbreaks and surges of infection within communities. The University of Louisville in partnership with Louisville’s Department of Public Health and Wellness tested this strategy in 2021 and 2022. This Wastewater-Informed Public Health Intervention Playbook describes the decisions and actions of that academic and public …

Racial Ethnic Disparities In Functional Limitations And Depression Symptoms During The Covid-19 Pandemic, Hui Liew

Journal of Public Health in the Deep South

Purpose: This study seeks to examine how the impacts of physical and mental comorbidities and functional limitations on depressive symptoms vary by the major racial ethnic groups (i.e. Whites, Blacks, and Hispanics).Methods: The empirical work of this is based on the United States using data from the 2020 Health and Retirement Study (HRS) COVID-10 Project.Results: Findings suggest that physical and mental comorbid conditions, functional limitations and depressive symptoms co-occur more commonly than expected for all racial ethnic groups. Females fare worse than males in terms of functional imitations (for all racial ethnic groups) and depressive symptoms (Whites only). Education has …

American Indians And Covid-19: Morbidity And Mortality Disparities Among Indigenous Populations In The Rural South, Leslie Musshafen, Thomas E. Dobbs, Aaron Robinson, Thomas Wyatt, Michael Puskarich, Richard Summers, Seth Lirette, Caroline Compretta

Journal of Public Health in the Deep South

Background The COVID-19 pandemic has highlighted health inequities among indigenous populations, with those in rural settings facing compounded barriers.Purpose To investigate morbidity and mortality experiences among hospitalized, COVID-19+ American Indian adults from rural and urban settings.Methods The described cross-sectional study used retrospective discharge data from the University of Mississippi Medical Center and Hennepin County Medical Center. Adults (≥ age 18) admitted from January 1, 2020 to August 8, 2021with a COVID-19 diagnosis and known race were included.Results A total of 3,659 inpatients met inclusion criteria. Among adults hospitalized with COVID-19 at the University of Mississippi Medical Center, American Indians (n=73) …