Digital Commons Network^™

Identifying Factors Associated With Syringe Reuse Among People Who Inject Drugs (Pwid) In Appalachia Kentucky, Grayson Keith Fuller

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Aim: Syringe reuse contributes to the spread of infectious diseases. The purpose of this study is to identify factors associated with syringe reuse among people who inject drugs (PWID) in Kentucky.

Methods: PWID (n=238) completed interviewer-administered questionnaires to collect data on syringe reuse and demographic, behavioral, and clinical characteristics. Negative log binomial regression was used to model the associations.

Results: On average, people reused each syringe 9.3 times (median: 3; IQR: 2-10, range 1-95). Syringe reuse was higher among men [aOR=1.386; 95% CI: 1.041-1.845] and those who injected methamphetamine [aOR=2.122; 95% CI: 1.445-3.116]. Reuse was also higher among those who …

Covid-19 Mitigation Strategies School Staff In Indiana, Kentucky, And Ohio, Luu Le

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Abstract

Background: This cross-sectional study aims to identify the difference in COVID-19 mitigation strategies implementation and adherence among elementary, middle, and high schools in Indiana, Ohio, and Kentucky, based on data from the School Staff Health and Wellness Study research at the University of Kentucky in 2020.

Methods: The sample size of the study was 6,794 participants who work at elementary, middle, or high schools in Indiana, Ohio, and Kentucky. Complete case analyses were performed, which included observation with no missingness in variables (N = 5,971). Descriptive statistics were generated, including a table indicating the implementation of COVID-19 mitigation strategies …

Comparing Governmental Communication About Covid-19 Layered Protection Strategies In Taiwan, Kenya, And The United States: A Mixed-Method Analysis Of National Health Agency Websites, Cynthia Mofunanya

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

COVID-19 is a novel coronavirus caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It can result in severe respiratory damage. Different countries have recommended different combinations of protections during the COVID-19 pandemic. Various combinations of mitigation strategies or “layered protections” against coronavirus have also been communicated differently across nations. This mixed-methods content analysis seeks to compare COVID-19 mitigation information on three national health agency websites for Taiwan, Kenya, and the United States. Availability and navigability of information was examined for each mitigation strategy. The Web Resource Rating tool was used to assess the quality of the information about …

The Frequency Of Periodontitis In End‑Stage Renal Disease On Hemodialysis In A Sample Of Egyptian Population: Multi‑Center Clinical Cross‑Sectional Study, Enji Ahmed Mahmoud, Asmaa Abobakr, Eman Khalil, Radwa Raghib

Dentistry

Background: There is a general assumption that periodontal disease is highly prevalent among patients with chronic renal failure undergoing hemodialysis. The aim of the study to estimate the frequency of periodontitis in patients on hemodialysis among a sample of the Egyptian population, as well as the correlation between different clinical parameters of periodontal status with serum creatinine and blood urea. This may rule out the bidirectional relationship between periodontitis and renal failure in patients on hemodialysis. Methods: The study was conducted on 263 hemodialysis patients (165 males and 98 females) at three dialysis centers in Benha Governorate, Egypt (Benha Hospital, …

The Next Pandemic Might Be A Petdemic, Hillary Greene

Faculty Articles and Papers

A new scientific study shows that COVID-19 can be transmittedf rom cats to humans. Luckily, this channel of transmission seems extremely rare, at least thus far. But next time and there will be a next time we may not be so fortunate. This Article addresses this underappreciated risk of what I term a "petdemic" a pandemic or epidemic that involves significant disease transmission between pets and humans. With nearly 70% of U.S. households owning pets, a petdemic could be catastrophic. One of our go-to responses for even perceived petdemics, honed over the last century, is to slaughter our pets. This …

Genomic Degeneration And Reduction In The Fish Pathogen Mycobacterium Shottsi, David T. Gauthier, Janis H. Doss, M. Lagatta, T. Gupta, R.K. Karls, F. D. Quinn

Biological Sciences Faculty Publications

Mycobacterium shottsii is a dysgonic, nonpigmented mycobacterium originally isolated from diseased striped bass (Morone saxatilis) in the Chesapeake Bay, USA. Genomic analysis reveals that M. shottsii is a Mycobacterium ulcerans/Mycobacterium marinum clade (MuMC) member, but unlike the superficially similar M. pseudoshottsii, also isolated from striped bass, it is not an M. ulcerans ecovar, instead belonging to a transitional group of strains basal to proposed “Aronson” and “M” lineages. Although phylogenetically distinct from the human pathogen M. ulcerans, the M. shottsii genome shows parallel but nonhomologous genomic degeneration, including massive accumulation of pseudogenes accompanied by proliferation of …

Rickettsial Pathogen Perturbs Tick Circadian Gene To Infect The Vertebrate Host, Supreet Khanal, Vikas Taank, John F. Anderson, Hameeda Sultana, Girish Neelakanta

Biological Sciences Faculty Publications

Ixodes scapularis is a medically important tick that transmits several microbes to humans, including rickettsial pathogen Anaplasma phagocytophilum. In nature, these ticks encounter several abiotic factors including changes in temperature, humidity, and light. Many organisms use endogenously generated circadian pathways to encounter abiotic factors. In this study, we provide evidence for the first time to show that A. phagocytophilum modulates the arthropod circadian gene for its transmission to the vertebrate host. We noted a circadian oscillation in the expression of arthropod clock, bmal1, period and timeless genes when ticks or tick cells were exposed to alternate 12 h …

Editorial: Tick Saliva: Secret To Blood Feeding Success, Daniel E. Sonenshine, Patricia A. Nuttall, Sukanya Narasimhan

Biological Sciences Faculty Publications

No abstract provided.

Bone Morphogenetic Proteins Shape TReg Cells, Piotr Kraj

Biological Sciences Faculty Publications

The transforming growth factor-β (TGF-β) family includes cytokines controlling cell behavior, differentiation and homeostasis of various tissues including components of the immune system. Despite well recognized importance of TGF-β in controlling T cell functions, the immunomodulatory roles of many other members of the TGF-β cytokine family, especially bone morphogenetic proteins (BMPs), start to emerge. Bone Morphogenic Protein Receptor 1α (BMPR1α) is upregulated by activated effector and Foxp3+ regulatory CD4+ T cells (Treg cells) and modulates functions of both of these cell types. BMPR1α inhibits generation of proinflammatory Th17 cells and sustains peripheral Treg cells. This finding underscores the importance of …

Public Perception Of Socio-Scientific Issues Do You Decide Based On Your Education, Your Experience Or Reading The News?, Burcu Demiralp

CGU Theses & Dissertations

One of the challenges humans face is making collective decisions with regards to controversial issues related to science, namely socio-scientific issues (SSIs). Genetic modification, nuclear energy, experimental drugs, 5G technology are a few examples of SSIs. Some of the concerns posed by such issues are compromise to privacy and identity, threat to the workforce due to automation, and potential changes to the human genome. To better understand SSI-related decision making, it is important to understand the public perception of SSIs, while also including opinions of rural areas.This research investigated the perception of SSIs for the U.S. public both in a …

Equitable Pharmacogenetic Testing Implementation For Rural And Underserved Populations, Shayna Killam

Graduate Student Theses, Dissertations, & Professional Papers

Pharmacogenetic testing has potential to transform healthcare, yet implementation strategies have been limited to major academic medical centers serving metropolitan communities and large health systems. In contrast, rural, community-based health systems are slow to implement these advances, threatening to exacerbate existing healthcare disparities for rural populations. A majority of Montanans live in rural areas, with unique challenges in providing access to pharmacogenetics.

We have established partnerships with three clinical sites who serve rural, underserved populations including American Indian, pediatric, and low socioeconomic status patients. We conducted a needs assessment for pharmacogenetic testing implementation by interviewing 48 key stakeholders. Interview questions …

A Novel Pathway For The Production Of Poly-N-Acetylglucosamine By Borreliaceae, Adam Matthew Drobish

Graduate Student Theses, Dissertations, & Professional Papers

Poly-N-acetylglucosamine (PNAG) is an extracellular polysaccharide consisting of β-1,6 N-acetylglucosamine monomers. PNAG is a key component of biofilms produced by diverse bacteria including Escherichia coli, Staphylococcus aureus, Yersinia pestis, Bacillus subtilis¸and many more. The structure of PNAG is highly conserved across the microbial world. Here, we demonstrate that PNAG is produced by two Borrelia species, Borrelia (Borreliella) burgdorferi and Borrelia hermsii. PNAG production in B. burgdorferi, the Lyme disease spirochete, depends on pngA (bb0620), a gene annotated to express a glycosyl hydrolase family 3 (GH3) enzyme, which is a novel pathway. Surprisingly, in B. burgdorferi, PNAG appears to be intracellular, …

Tick Transmission Of Borrelia Burgdorferi To The Murine Host Is Not Influenced By Environmentally Acquired Midgut Microbiota, Sukanya Narasimhan, Nallakkandi Rajeevan, Morven Graham, Ming-Jie Wu, Kathleen Deponte, Solenne Marion, Orlanne Masson, Anya J. O'Neal, Daniel E. Sonenshine, Erol Fikrig

Biological Sciences Faculty Publications

Background

Ixodes scapularis is the predominant tick vector of Borrelia burgdorferi, the agent of Lyme disease, in the USA. Molecular interactions between the tick and B. burgdorferi orchestrate the migration of spirochetes from the midgut to the salivary glands—critical steps that precede transmission to the vertebrate host. Over the last decade, research efforts have invoked a potential role for the tick microbiome in modulating tick-pathogen interactions.

Results

Using multiple strategies to perturb the microbiome composition of B. burgdorferi-infected nymphal ticks, we observe that changes in the microbiome composition do not significantly influence B. burgdorferi migration from the midgut, invasion of …

The Role Of Response Efficacy And Risk Aversion In Promoting Compliance During Crisis, Veronica L. Thomas, Hooman Mirahmad, Grace Kemper

Marketing Faculty Publications

This research examines consumers' compliance with behaviors that focus on preventing the spread of COVID‐19. Drawing on Protection Motivation Theory and research on efficacy, we find that, during a pandemic, consumers who have higher perceptions of response efficacy are less likely to engage in risky consumption behaviors (Study 1) and more likely to engage in protective consumption behaviors (Study 2). This effect is moderated by risk aversion, such that as risk aversion increases, COVID‐compliant behaviors increase even when consumers do not believe in their ability to effectuate change. Further, the relationship between response efficacy and COVID‐compliant behaviors is mediated by …

Investigating Public Support For Biosecurity Measures To Mitigate Pathogen Transmission Through The Herpetological Trade, Elizabeth F. Pienaar, Diane J. Episcopio-Sturgeon, Zachary T. Steele

Biological Sciences Faculty Publications

The expanding global trade in herpetofauna has contributed to new infectious disease dynamics and pathways that allow for the rapid spread of pathogens geographically. Improved biosecurity is needed to mitigate adverse biodiversity, economic and human health impacts associated with pathogen transmission through the herpetological trade. However, general lack of knowledge of the pathogen transmission risks associated with the global trade in herpetofauna and public opposition to biosecurity measures are critical obstacles to successfully preventing pathogen transmission. In 2019 we administered a survey to 2,007 members of the public in the United States of America to ascertain their support for interventions …

Evolution And Effectiveness Of The Governmental Risk And Crisis Communication On Twitter In The Covid-19 Pandemic: The Case Of Switzerland, Albena Björck, Audra Diers-Lawson, Felix Dücrey

International Crisis and Risk Communication Conference

The Covid-19 pandemic has challenged the risk and crisis communication capabilities of governmental authorities: A new global phenomenon had to be managed and explained on a national and local level to protect public health. In the form of a single case study, the current research investigates this complex event as a cumulative crisis, the evolution of the communication strategies, and the effectiveness of messaging using Twitter in the context of Switzerland. The study identifies improvement potential in existing theoretical frameworks and provides a method for governmental authorities to track and assess their communication efforts.

Covid-19 News Frames In Sports Headlines In England: A Content Analysis, Yazeed Aljasser

International Crisis and Risk Communication Conference

This study examined the nature of sports reporting of COVID19 in England by employing framing analysis on a sample of five newspapers. Through a quantitative content analysis, this study revealed how sports news coverage framed the COVID19 virus in these newspapers: The Times, The Daily Telegraph, The Daily Mirror, The Daily Mail, and the Sun. The findings revealed that Competition and Players and Staff frames were the Major frames in the headlines media news organizations reported on COVID19. Implications and future research needs are discussed.

Public Opinion In A Pandemic: Four Surveys Conducted With Americans Throughout The Covid-19 Pandemic, Lauri M. Baker, Chen-Xian Yang, Angela B. Lindsey, Ashley Mcleod-Morin, Ricky W. Telg, Anissa Zagonel, Sydney Honeycutt, Naik Wali, Shelli Rampold

International Crisis and Risk Communication Conference

The UF/IFAS Center for Public Issues Education in Agriculture and Natural Resources (PIE Center) conducted a series of national public opinion surveys to examine the perceptions of Americans related to COVID-19. The PIE Center conducted four surveys with ~1,500 Americans per survey from mid-March 2020 to January 2021. The surveys sought to understand Americans’ perceptions of a range of topics including health and communication concerns, vaccination perceptions and acceptance, mask understanding and willingness, and compound disasters and stress. Presentations in this panel highlight key areas of research from this survey series and share how communicators can use this research to …

Spillover And Cascading Crises In Public Health And Water Systems: The Orlando Liquid Oxygen Shortage, Ronisha Sheppard, Shawn P. Mcelmurry, Matt W. Seeger

International Crisis and Risk Communication Conference

In August 2021, COVID cases spiked in Florida with over 24,000 breakthrough cases per day making Florida the state with the highest increase at the time. Florida saw an increase in hospitalized COVID-19 patients during the last two weeks of August and became the 3rd state in the U.S. to exceed 3 million COVID cases. Not only did this impact public health, but it also created an unforeseen impact on the municipal water system. The surge in COVID cases created a surge in demand for treatment, one in which included liquid oxygen, used for respiratory therapy. Without liquid oxygen, ozone …

Methods For Characterization Of Cl-001 Derived Exosomes As A Stimulating Agent For Nk Cells For Immunotherapy, Ilana Gomez Diaz

Honors Undergraduate Theses

The immune system is a complex set of cells in the body that work to prevent disease or infection by recognizing and eliminating foreign material or unhealthy cells. One essential type of immune cell that is part of the innate immune response are Natural Killer (NK) cells. These cytotoxic effector lymphocytes can detect certain unhealthy cells, such as cancer cells, that normal B and T cells would miss. For example, many tumor cells have evolved to bypass immune system surveillance by not expressing major histocompatibility complex class I molecules (MHC class I), on their surface, reducing recognition by cytotoxic T …

City Of The Future Theories : A Diachronic Comparative Study, Gildis Tachir, Ayşe Nilay Evcil

Journal of Urban Culture Research

This paper strives to interpret the future city or the future of the city by searching published articles. To do this, a review of literature had been made and articles from urban planning and architecture perspectives were studied. We collected information on the time-varying indicators that make up the cities of the future. In this study, it is investigated how the problems arise periodically and the indicators in the formation of the city plans of the future. It concludes with some foresights about next fifty years’ city futures of the millennium.

Intrahost Diversity Of Staphylococcus Aureus In Carriage Among Native Americans, Julia Webb

Electronic Theses and Dissertations, 2020-2023

Staphylococcus aureus (SA) is an opportunistic pathogen and a commensal member of the human microbiota that frequently colonizes the upper respiratory tract and skin. While SA can cause disease ranging from minor skin infections to life-threatening septicemia, it can also be carried asymptomatically. As carriage is the most significant risk factor for SA disease, surveillance is important for the prevention of outbreaks in vulnerable communities. Native Americans have a greater risk of infectious disease than the general US population, and Native Americans in the Southwestern United States have been shown to experience high rates of invasive SA disease. Here we …

Remote Learning During Covid-19 On Internal Medicine Residents' Education: Barriers And Enhancements Through Lived Experiences, Stephanie Rivera-Velazquez

Electronic Theses and Dissertations, 2020-2023

The COVID-19 pandemic uncovered instructional changes within higher education. Accommodations for continued instruction included a transition to remote learning. However, little research exists regarding the experiences of medical residents during this transition in their education while combating the COVID-19 pandemic. This qualitative study, phenomenological in nature, aimed to explore the lived experiences of internal medicine medical residents at one medical college in Central Florida regarding the transition from face-to-face instruction to remote learning due to the COVID-19 pandemic. Eleven participating medical residents underwent semi-structured interviews via Zoom. Garrison's Community of Inquiry conceptual model and Hall and Hord's Concerns-Based Adoption Model …

Application Of Molecular Tools To Assess Toxicity In Industrial Wastewater And Track Viral Pathogens In Municipal Wastewaters, Mina Aghababaei Shahrestani

Doctoral Dissertations

Wastewater is a complex matrix containing a wide range of microorganisms and chemical compounds. For public health purposes, it is critical to monitor for harmful microorganisms and evaluate the toxicity of chemicals present in industrial and municipal wastewaters on human and ecosystem health. Over the past decade, sophisticated technologies such as high-throughput sequencing have enabled the development of molecular tools, which are now widely employed for tracking pathogens and assessing toxicity of municipal and industrial wastewaters. Molecular tools for biomonitoring of wastewater are designed to target specific microbial biomarkers including nucleic acids, proteins and antigens. Accordingly, this dissertation applied molecular …

Thinking Beyond Bacterial Infection: A Case Of Cutaneous Blastomycosis, Mehakmeet Bhatia, Vivek Kak, Parth Patel, Alexander A. Slota

Hematology/Oncology Articles

Blastomycosis is caused by Blastomyces dermatitidis, a dimorphic fungus that primarily causes pulmonary disease. Cutaneous blastomycosis is infrequent and tends to be misdiagnosed given its similar presentation to other cutaneous fungal infections and malignancies. A 51-year-old woman presented with a two-month history of disfiguring nasal lesions. The patient had a past medical history of cervical cancer which was currently in remission. Social history was significant for frequent travel throughout the United States as a truck driver, including the Midwest. The patient had a non-purulent verrucous plaque on her right nare, which was painless and mildly pruritic. Superficial cultures grew …

A Scoping Review Comparing Sustainable Diet Indices, Natalie Henning

Public Health Theses

Interest in environmentally sustainable diets (i.e., diets beneficial for both human and planetary health) has increased as the role of food systems in climate change and population health has become better understood. Sustainable diet indices have been proposed as a holistic approach to assessing diets around the world with regards to human and planetary outcomes. The aim of this scoping review was to summarize and compare sustainable diet indices and their applicability to various populations.A literature search of three databases (Scopus, PubMed, and the Climate Change and Human Health Literature Search Portal) was conducted to identify articles that developed, validated, …

Comprehensive West Nile Virus Phylogenetic Analysis: Europe And Beyond, Robert T. Koch

Public Health Theses

ABSTRACT West Nile virus (WNV) inhabits a unique position in the infectious disease landscape. It is both the most widespread arbovirus in the world, and yet is one of the least known. WNV is spread by mosquitoes and has high morbidity and mortality in birds, humans are dead-end hosts of the virus but can develop a serious neuroinvasive form of the disease (WNND). The incidence of such cases is on the rise around the world. To explore WNV, we created a comprehensive phylogenetic analysis with all available WNV genomes in genbank database using Nextstrain to identify use cases for increasing …

Identification Of An In Vitro Medium For Leptospira Spp. As A Surrogate For Host Environment, Using Rna-Seq Transcriptome Analysis, Zitong Lin

Public Health Theses

Pathogenic Leptospira species causes millions of leptospirosis cases around the world and is an urgent public health issue that needs to be properly addressed. The infection leads to clinical manifestations ranging from self-limiting febrile illness to severe life-threatening symptoms. Currently, there is a lack of sensitive assay for early diagnosis of leptospirosis, and there is no FDA-approved vaccine for human use in the United States. Despite the worldwide occurrence of this zoonotic disease, low and middle-income countries are disproportionately affected by it. A better understanding of the pathogenesis of Leptospira is a crucial step for the development of better diagnostic …

No-Fault Vaccine Injury Compensation Systems Adopted Pursuant To The Covid-19 Public Health Emergency Response, Sam Halabi, Katherine Ginsbach, Katie Gottschalk, John Monahan, Judith Murungi

Emory International Law Review

No-fault vaccine injury compensation systems have developed over the course of the twentieth century, mostly in the richest countries in the world. Acknowledging that severe reactions to vaccines are rare, but can result in serious and sometimes complex injury, these systems provide financial and social support for those suffering these rare side effects. During the COVID-19 pandemic, and the rapid development and deployment of vaccines using novel technologies, these systems have proliferated not only among wealthy countries, where in their modern form they originated and spread, but also low- and middle-income ones. Adopting varying approaches to funding, eligibility, administration, process, …

Stifling Innovation: How Global Data Protection Regulation Trends Inhibit The Growth Of Healthcare Research And Start-Ups, Ryan Preston

Emory International Law Review

No abstract provided.