Digital Commons Network^™

Emerging Biomedical Applications Of The Vesicular Stomatitis Virus Glycoprotein, Sheeba Rehman, Suman Bishnoi, Rajarshi Roy, Anshu Kumari, Harikrishnan Jayakumar, Sharad Gupta, Parimal Kar, Asit K. Pattnaik, Bebasis Nayak

School of Veterinary and Biomedical Sciences: Faculty Publications

Nanoparticles (NPs) made of metals, polymers, micelles, and liposomes are increasingly being used in various biomedical applications. However, most of these NPs are hazardous for long- and short-term use and hence have restricted biomedical applications. Therefore, naturally derived, biocompatible, and biodegradable nanoconstructs are being explored for such applications. Inspired by the biology of viruses, researchers are exploring the viral proteins that hold considerable promise in biomedical applications. The viral proteins are highly stable and further amenable to suit specific biological applications. Among various viral proteins, vesicular stomatitis virus glycoprotein (VSV-G) has emerged as one of the most versatile platforms for …

Phip-Seq Reveals Autoantibodies For Ubiquitously Expressed Antigens In Viral Myocarditis, Mahima T. Rasquinha, Ninaad Lasrado, Erika M. Petro-Turnquist, Eric A. Weaver, Thiagarajan Venkataraman, Daniel R. Anderson, H. Benjamin Larman, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Simple Summary: Myocarditis is the inflammation of the heart muscle, and viral infections are a common cause of this disease. Myocarditis in some patients can progress to dilated cardiomyopathy (DCM). The mouse model of coxsackievirus B3 (CVB3) is commonly used to understand this disease progression in DCM patients. In this paper, we have attempted to analyze antibodies for heart antigens that could be produced as a result of heart damage in animals infected with CVB3 using a technique called Phage ImmunoPrecipitation Sequencing (PhIP-Seq). The analyses led us to identify antibodies for several proteins that were not previously reported that may …

Ending ‘Period Poverty’: A Holistic Proposal To Address Menstrual Hygiene Management For People Experiencing Homelessness In Denver, Colorado., Emily Weber

Regis University Student Publications (comprehensive collection)

This proposal is for a holistic, community-based approach to MHM, with a specific focus on people experiencing homelessness in Denver, Colorado. The proposal culminates in a holistic set of recommendations, including both actionable items and systems- and policy- level suggestions, to improve access to clean and dignified MHM for the intended beneficiaries.

The goals of this proposal are to: 1) Increase community collaboration on addressing MHM; 2) Provide equitable access to MHM products for all people experiencing homelessness; 3) Reduce the stigma associated with MHM; 4) Provide safe, private, and clean spaces for dignified MHM in Denver; and 5) Create …

Bill Gatton College Of Pharmacy Viewbook - 2022, Bill Gatton College Of Pharmacy, East Tennessee State University

Bill Gatton College of Pharmacy Miscellaneous Publications

No abstract provided.

The 2021 Eurpean Alliance Of Associations For Rheumatology/American College Of Rheumatology Points To Consider For Diagnosis And Management Of Autoinflammatory Type I Interferonopathies: Candle/Praas, Savi And Ags, Kader Cetin Gedik, Lovro Lamot, Micol Romano, Erkan Demirkaya, David Piskin, Sofia Torreggiani, Laura A. Adang, Thais Armangue, Kathe Barchus, Devon R. Cordova, Yanick J. Crow, Russell C. Dale, Karen L. Durrant, Despina Eleftheriou, Elisa M. Fazzi, Marco Gattorno, Francesco Gavazzi, Eric P. Hanson, Min Ae Lee-Kirsch, Gina A. Montealegre Sanchez, Bénédicte Neven, Simona Orcesi, Seza Ozen, M. Cecilia Poli, Elliot Schumacher, Davide Tonduti, Katsiaryna Uss, Daniel Aletaha, Brian M. Feldman

Paediatrics Publications

Objective: Autoinflammatory type I interferonopathies, chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature/proteasome-associated autoinflammatory syndrome (CANDLE/PRAAS), stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI) and Aicardi-Goutières syndrome (AGS) are rare and clinically complex immunodysregulatory diseases. With emerging knowledge of genetic causes and targeted treatments, a Task Force was charged with the development of 'points to consider' to improve diagnosis, treatment and long-term monitoring of patients with these rare diseases. Methods: Members of a Task Force consisting of rheumatologists, neurologists, an immunologist, geneticists, patient advocates and an allied healthcare professional formulated research questions for a systematic literature …

Methamphetamine Use: A Narrative Review Of Adverse Effects And Related Toxicities., Amber N. Edinoff, Sarah E. Kaufman, Keionne M. Green, Daniel A. Provenzano, Jesse Lawson, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Methamphetamine has been labeled "America's most dangerous drug" and has received significant public health attention. Stimulant addiction and tolerance are heavily documented in the literature; increasingly larger doses maintain euphoria in short time periods to withstand stimulant tolerance. Stimulant deaths are high in the United States and abroad. Between 2013 and 2019, deaths related to methamphetamine use quadrupled from 3,616 to 16,127. Methamphetamine use increased four-fold from 2015 to 2016. Due to this increase in methamphetamine use and its associated medical complications, the mortality rate associated with methamphetamine use has doubled over the past ten years. Cardiopulmonary symptoms include chest …

Nebraska Annual Social Indicators Survey (Nasis) 2022 Methodology Report, Bureau Of Sociological Research

Nebraska Annual Social Indicators Survey (NASIS)

No abstract provided.

The "War On Drug." The "War On Terror." Now, The War On Covid-19: A History Of Anti-Aapi Hate In The U.S. During Public Health Emergencies, Mohamed Fahim Khan

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Treatment Heterogeneity In Pseudomonas Aeruginosa Pneumonia, Aisling R. Caffrey, J. Appaneal, J. Xin Liao, Emily C. Piehl, Vrishali Lopes, Laura A. Puzniak

Pharmacy Practice and Clinical Research Faculty Publications

We have previously identified substantial antibiotic treatment heterogeneity, even among organism-specific and site-specific infections with treatment guidelines. Therefore, we sought to quantify the extent of treatment heterogeneity among patients hospitalized with P. aeruginosa pneumonia in the national Veterans Affairs Healthcare System from Jan-2015 to Apr-2018. Daily antibiotic exposures were mapped from three days prior to culture collection until discharge. Heterogeneity was defined as unique patterns of antibiotic treatment (drug and duration) not shared by any other patient. Our study included 5300 patients, of whom 87.5% had unique patterns of antibiotic drug and duration. Among patients receiving any initial antibiotic/s with …

Ser-109: An Oral Investigational Microbiome Therapeutic For Patients With Recurrent Clostridioides Difficile Infection (Rcdi), Sahil Khanna, Sims, Thomas J. Louie, Monika Fischer, Kerry L. Laplante, Jessica Allegretti, Brooke R. Hasson, Allyson T. Fonte, Christopher Mcchalicher, David S. Ege, Jessica A. Bryant, Timothy J. Straub, Christopher B. Ford, Matthew R. Henn, Elaine E.L. Wang, Lisa Von Moltke, Mark H. Wilcox

Pharmacy Practice and Clinical Research Faculty Publications

Clostridioides difficile infection (CDI) is classified as an urgent health threat by the Centers for Disease Control and Prevention (CDC), and affects nearly 500,000 Americans annually. Approximately 20–25% of patients with a primary infection experience a recurrence, and the risk of recurrence increases with subsequent episodes to greater than 40%. The leading risk factor for CDI is broad-spectrum antibiotics, which leads to a loss of microbial diversity and impaired colonization resistance. Current FDA-approved CDI treatment strategies target toxin or toxin-producing bacteria, but do not address microbiome disruption, which is key to the pathogenesis of recurrent CDI. Fecal microbiota transplantation (FMT) …

Impact Of Clopidogrel On Clinical Outcomes In Patients With Staphylococcus Aureus Bacteremia: A National Retrospective Cohort Study, Aisling R. Caffrey, J. Appaneal, Kerry L. Laplante, Vrishali V. Lopes, Erlinda R. Ulloa, Victor Nizet, George Sakoulas

Pharmacy Practice and Clinical Research Faculty Publications

Activated platelets have known antimicrobial activity against Staphylococcus aureus. Accelerated clearance of platelets induced by S. aureus can result in thrombocytopenia and increased mortality in patients. Recent studies suggest that P2Y12 inhibition protects platelets from accelerated clearance. We therefore evaluated the effect of P2Y12 inhibition on clinical outcomes in patients with S. aureus bacteremia across a large national cohort. Our retrospective cohort (2010 to 2018) included patients admitted to Veterans Affairs (VA) hospitals with blood cultures positive for S. aureus and treated with standard-of-care antibiotics. Employing propensity score-matched Cox proportional hazards regression models, we compared clinical outcomes in …

Investigating The Antibacterial Activity Of Novel Metal Complexes Against Antimicrobial Resistant Pathogens, Megan O'Shaughnessy

Theses, Doctoral

Antimicrobial resistance (AMR) is one of the serious global health challenges of our time. There is an urgent need to develop novel therapeutic agents to overcome AMR, preferably through alternative mechanistic pathways from conventional treatments. Interdisciplinary research in inorganic medicinal chemistry with biology is advancing the knowledge and implementation of transition metal complexes for therapy and is offering a realistic alternative to traditional antibiotics. Metal complexes with 1,10-phenanthroline (phen) ligands have demonstrated promising therapeutic capabilities with diverse biological activity. Consequently, there has been a resurgence in research of these complexes as possible alternatives or adjuvants to established antimicrobial clinical therapeutics. …

Using The Protection Motivation Theory To Understand The Mental Health Impact Of Surviving Covid-19, Kaprea Johnson, Angel Spence, Yousef Sherif, Dana Brookover, Adrienne White

Adultspan Journal

Due to the widespread effects of COVID-19, mental health professionals need to understand the lived experiences of survivors. Data were collected from YouTube videos (N = 52), which contained firsthand perspectives from COVID-19 survivors. Survivors understood the high stakes of COVID-19, reported the dual threat to physical and mental health, entered “survival mode,” and had both positive and negative reflections on the experience. Implications for mental health professionals and future research directions are included.

Unm Health Sciences Center Data Book 2021-22, University Of New Mexico - Health Sciences Center

Health Sciences Center Databook (1990-ongoing)

No abstract provided.

Project Echo Annual Report 2022, University Of New Mexico, Health Sciences Center, Project Echo Communications Team

Project ECHO Annual Reports

No abstract provided.

University Of New Mexico Health Sciences Center Discovery Research Annual Report 2022, Michael Haederle, Sara Mota, El Webb, Chris Corrie, Byron Hughey-Geer, Jett Loe, Sarah Head, Elizabeth Sandlin

Research Annual Reports

No abstract provided.

No Panacea Attractant For Wild Pigs (Sus Scrofa), But Season And Location Matter, Nathan P. Snow, Caitlin A. Kupferman, Michael J. Lavelle, Kim M. Pepin, Madeline H. Melton, Whitney J. Gann, Kurt C. Vercauteren, James C. Beasley

United States Department of Agriculture Wildlife Services: Staff Publications

Wild pigs (Sus scrofa) are a prolific invasive species throughout many regions of the world that cause extensive economic and environmental damage. Trapping is a common strategy for reducing their populations with baits (i.e., food) and attractants (e.g., scents) used to lure wild pigs into traps. However, there is little information on which scent attractants may attract wild pigs more readily and rapidly across regions and seasons. We examined 60 scent attractants for wild pigs that could be used to increase trapping success across three seasons (winter, spring, and fall) and in two geographic regions, including a warm …

Predation Thresholds For Reintroduction Of Native Avifauna Following Suppression Of Invasive Brown Treesnakes On Guam, Robert M. Mcelderry, Eben H. Paxton, Andre V. Nguyen, Shane R. Siers

United States Department of Agriculture Wildlife Services: Staff Publications

The brown treesnake (BTS) (Boiga irregularis) invasion on Guåhan (in English, Guam) led to the extirpation of nearly all native forest birds. In recent years, methods have been developed to reduce BTS abundance on a landscape scale. To help assess the prospects for the successful reintroduction of native birds to Guåhan following BTS suppression, we modeled bird population persistence based on their life history characteristics and relative sensitivity to BTS predation. We constructed individual-based models and simulated BTS predation in hypothetical founding populations for each of seven candidate bird species. We represented BTS predation risk in two steps: …

Conserving Endangered Black-Footed Ferrets: Biological Threats, Political Challenges, And Lessons Learned, Travis M. Livieri, Steven C. Forrest, Marc R. Matchett, Stewart Breck

United States Department of Agriculture Wildlife Services: Staff Publications

There may be few stories in the annals of wildlife management that are as dramatic as the near demise and comeback of the black-footed ferret (Mustela nigripes). Endemic only to North America, this charming little carnivore found only in the continent’s central grasslands was hardly known to science until the mid-20th century. By then, vast colonies of the prey it depended on for food and shelter, the prairie dog (Cynomys spp.), had been wiped out through disease (sylvatic plague) and an agricultural industry with little tolerance for burrowing and grazing rodents. At its low point, the species’ …

2022 Program, University Of Missouri-St. Louis

Undergraduate Research Symposium

University of Missouri-St. Louis Undergraduate Research Symposium Program

Simulated Cost-Effectiveness And Long-Term Clinical Outcomes Of Addiction Care And Antibiotic Therapy Strategies For Patients With Injection Drug Use-Associated Infective Endocarditis, Joëlla W. Adams, Alexandra Savinkina, James C. Hudspeth, Mam Jarra Gai, Raagini Jawa, Laura R. Marks, Benjamin P. Linas, Alison Hill, Jason Flood, Simeon Kimmel, Joshua A. Barocas

Open Access Publications

Importance: Emerging evidence supports the use of outpatient parenteral antimicrobial therapy (OPAT) and, in many cases, partial oral antibiotic therapy for the treatment of injection drug use-associated infective endocarditis (IDU-IE); however, long-term outcomes and cost-effectiveness remain unknown.

Objective: To compare the added value of inpatient addiction care services and the cost-effectiveness and clinical outcomes of alternative antibiotic treatment strategies for patients with IDU-IE.

Design, Setting, and Participants: This decision analytical modeling study used a validated microsimulation model to compare antibiotic treatment strategies for patients with IDU-IE. Model inputs were derived from clinical trials and observational cohort studies. The model included …

Serologic And Cytokine Signatures In Children With Multisystem Inflammatory Syndrome And Coronavirus Disease 2019, Stacey A. Lapp, Carol M. Kao, David A. Hunstad, Et Al

Open Access Publications

Background: The serologic and cytokine responses of children hospitalized with multisystem inflammatory syndrome (MIS-C) vs coronavirus disease 2019 (COVID-19) are poorly understood.

Methods: We performed a prospective, multicenter, cross-sectional study of hospitalized children who met the Centers for Disease Control and Prevention case definition for MIS-C (n = 118), acute COVID-19 (n = 88), or contemporaneous healthy controls (n = 24). We measured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD) immunoglobulin G (IgG) titers and cytokine concentrations in patients and performed multivariable analysis to determine cytokine signatures associated with MIS-C. We also measured nucleocapsid IgG and …

Understanding Covid-19 Among People Of Dominican Descent In The U.S.: A Comparison Of New York, New Jersey, Florida, Massachusetts, Pennsylvania, Rhode Island And Connecticut, Ramona Hernandez, Pedro Ortega, Nancy Sohler, Sarah Marrara

Publications and Research

The present study “Understanding COVID-19 Among People of Dominican Descent in the U.S.: A Comparison of New York, New Jersey, Florida, Massachusetts, Pennsylvania, Rhode Island and Connecticut” is the first research study to examine the experience of people of Dominican origins residing in the United States (U.S.) amidst the pandemic caused by the SARS-CoV-2 virus. The current study is based on a probabilistic and representative sample of Dominicans across the seven states in which the majority—85%—of Dominicans living in the U.S. reside. The Dominican Studies Institute (CUNY-DSI) at City College and the School of Medicine, both of the City University …

The Urban Maroons Of Afro-Dominican Music, Paul Austerlitz

Publications and Research

No abstract provided.

Race-Specific, State-Specific Covid-19 Vaccination Rates Adjusted For Age, Elizabeth Wrigley-Field, Kaitlyn M. Berry, Govind C. Persad

Sturm College of Law: Faculty Scholarship

The authors provide the first age-standardized race/ethnicity-specific, state-specific vaccination rates for the United States. Data encompass all states reporting race/ethnicity-specific vaccinations and reflect vaccinations through mid-October 2021, just before eligibility expanded below age 12. Using indirect age standardization, the authors compare racial/ethnic state vaccination rates with national rates. The results show that white and Black state median vaccination rates are, respectively, 89 percent and 76 percent of what would be predicted on the basis of age; Hispanic and Native rates are almost identical to what would be predicted; and Asian American/Pacific Islander rates are 110 percent of what would be …

Dose Optimisation And Scarce Resource Allocation: Two Sides Of The Same Coin, Garth Strohbehn, Govind C. Persad, William F. Parker, Srinivas Murthy

Sturm College of Law: Faculty Scholarship

Objective: A deep understanding of the relationship between a scarce drug's dose and clinical response is necessary to appropriately distribute a supply-constrained drug along these lines.

Summary of key data: The vast majority of drug development and repurposing during the COVID-19 pandemic – an event that has made clear the ever-present scarcity in health care systems –has been ignorant of scarcity and dose optimisation's ability to help address it.

Conclusions: Future pandemic clinical trials systems should obtain dose optimisation data, as these appear necessary to enable appropriate scarce resource allocation according to societal values.

A Comparative Analysis Of Covid-19 Vaccine Distribution Efforts In India And Mongolia Through Data Visualization, Paridhi Latawa, Sadhana Kumar, Udeshna Srimal, Rachana Tanksali, Edward Ning '23, Ajay Macherla, Haily Nguyen, Kristina Lian, Joy Jiang, Julia Ding, Daniel Stewart

External Student Research Opportunities

COVID-19 vaccine allocation efforts have posed challenges and offered opportunities to alleviate the ongoing pandemic. Nations have employed varying approaches for COVID-19 vaccine distribution; in particular, Mongolia and India have differed in approaches to vaccine allocation efforts. As of June 2021, Mongolia has vaccinated more than 60% of its population, whereas India has only vaccinated about 7.5%. This disparity highlights the need for the present study, which utilizes a mixed-method approach to examine the two countries' vaccine distribution strategies and COVID-19 containment policies from January to July 2021. The study has three major components: 1) policy analysis to highlight core …

Hell And High Water: How Climate Change Can Harm Prison Residents And Jail Residents, And Why Covid-19 Conditions Litigation Suggests Most Federal Courts Will Wait-And-See When Asked To Intervene, Paloma Wu, D. Korbin Felder

Fordham Urban Law Journal

No abstract provided.

Framing, Advice-Seeking, And Medical Trust In The R/Keto Community: An Analysis Of The Medical Flair On R/Keto, Sabrina Finke

Electronic Theses and Dissertations

First created in 1921, the ketogenic diet was used as a medical intervention for children suffering from severe epilepsy. However, in recent years, this highly restrictive diet has gained mainstream popularity for a number of illness management, wellness, and weight loss uses. Despite its rise in use and popularity, mainstream medical opinion still views the ketogenic diet as a last resort for severe conditions. Using a content analysis of posts tagged with the “medical” flair on the subreddit “r/Keto,” this thesis found commonalities among posts which praised the ketogenic diet and shared positive personal anecdotes were the most likely to …

Nasis 2022: Nebraska Annual Social Indicators Survey Questionnaire, Bureau Of Sociological Research

Nebraska Annual Social Indicators Survey (NASIS)

No abstract provided.