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The Impact Of Aging On The Lung Alveolar Environment, Predetermining Susceptibility To Respiratory Infections, Jordi B. Torrelles, Blanca I. Restrepo, Yidong Bai, Corinna Ross, Larry S. Schlesinger, Joanne Turner

School of Medicine Publications

Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictable tissue-specific changes that prevent the immune system from working effectively in the lung. This mini-review highlights recent evidence for altered local tissue environment factors as we age focusing on increased tissue oxidative stress with associated immune cell changes, likely driven by the byproducts of age-associated inflammatory disease. Potential intervention points are presented.

Surveillance Of Sars-Cov-2 Rna In Open-Water Sewage Canals Contaminated With Untreated Wastewater In Resource-Constrained Regions, Paramita Basu, Sandeepan Choudhury, Varsha Shridhar, Poorva Huilgol, Samrat Roychoudhury, Indranil Nandi, Angela Chaudhuri, Arindam Mitra

Touro College of Pharmacy (New York) Publications and Research

Sewage-based surveillance for COVID-19 has been described in multiple countries and multiple settings. However, nearly all are based on testing sewage treatment plant inflows and outflows using structured sewage networks and treatment systems. Many resource-limited countries worldwide have open canals, lakes and other such waste-contaminated water bodies that act as a means of sewage effluent discharge. These could serve as hyperlocal testing points for detecting COVID-19 incidence using the effluents from nearby communities. However, a sensitive, robust and economical method of SARS-CoV-2 RNA detection from open waste contaminated water bodies in resource-constrained regions is currently lacking. A protocol employed in …

The Rider (2022-01-18), Verilu Infante

The Rider Archives

Vol.7 No.15

The Effect Of Ivermectin On Non-Severe And Severe Covid-19 Disease And Gender-Based Difference Of Its Effectiveness, Syed Muhammad Zubair, Muhammad Waleed Chaudhry, Ali Bin Sarwar Zubairi, Talha Shahzad, Aqusa Zahid, Ibrahim Ali Khan, Javaid Ahmed Khan, Muhammad Irfan

Section of Pulmonary & Critical Care

The COVID-19 pandemic has led to mortality and morbidity since December 2019. Many possible treatment options have been advised till date. The role of ivermectin in the treatment of COVID-19 disease remains controversial. The aim of our study was to evaluate the effect of ivermectin in hospitalized patients with non-severe and severe COVID-19 disease. We conducted a retrospective cohort study that compared outcomes in 2 groups of COVID-19 patients hospitalized at the largest tertiary care center of Pakistan. The study group was given ivermectin along with standard treatment of covid-19 disease; the comparison group was not. Data on mortality, inflammatory …

2022-01-18_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

Amplification Of Emerging Viruses In A Bat Colony, Jan Felix Drexler, Victor Max Corman, Tom Wegner

KIP Articles

Bats host noteworthy viral pathogens, including coronaviruses, astroviruses, and adenoviruses. Knowledge on the ecology of reservoir-borne viruses is critical for preventive approaches against zoonotic epidemics. We studied a maternity colony of Myotis myotis bats in the attic of a private house in a suburban neighborhood in Rhineland-Palatinate, Germany, during 2008, 2009, and 2010. One coronavirus, 6 astroviruses, and 1 novel adenovirus were identified and monitored quantitatively. Strong and specific amplification of RNA viruses, but not of DNA viruses, occurred during colony formation and after parturition. The breeding success of the colony was significantly better in 2010 than in 2008, in …

See Legendary Jazz Guitarist Pat Metheny's Side-Eye Trio Live Feb. 13, Shannon Thomason

Browse All News

No abstract provided.

Monolayer Graphene Radiation Sensor With Backend Rf Ring Oscillator Transducer, Mohamed W. Tawfik, Abdelhameed Sharaf, Mohamed Serry

Faculty Journal Articles

This paper proposes a new graphene gamma- and beta-radiation sensor with a backend RF ring oscillator transducer employed to convert the change in the graphene resistivity due to ionizing irradiation into a frequency output. The sensor consists of a CVD monolayer of graphene grown on a copper substrate, with an RF ring oscillator readout circuit in which the percentage change in frequency is captured versus the change in radiation dose. The novel integration of the RF oscillator transducer with the graphene monolayer results in high average sensitivity to gamma irradiation up to 3.82 kΩ/kGy, which corresponds to a percentage change …

January 18, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The Biological Activity Of Mycosynthesized Silver Nanoparticles Against Some Pathogenic Bacteria, Rana Hikmet, Nehia Hussein

Journal of Applied Sciences and Nanotechnology

This study was carried out for the mycosynthesis of silver nanoparticles by Candida albicans supernatant.  All the isolates used in this study were taken from the patients who existed at Al-Elweya children's teaching hospital in Baghdad, Iraq. Mycosynthesized silver nanoparticles were characterized by color visualization, ultraviolet-visible (UV) spectroscopy, and Fourier transform infrared spectroscopy (FTIR). The UV-Vis spectroscopy examination has shown the highest absorbance (λmax) at the wavelength of 429 nanometers, which indicated the creation of silver nanoparticles. Furthermore, the results of the antibacterial potential of AgNO3 and AgNPs against Klebsiella pneumoniae and Staphylococcus haemolyticus bacteria showed the highest effect of …

Jib-04 Has Broad-Spectrum Antiviral Activity And Inhibits Sars-Cov-2 Replication And Coronavirus Pathogenesis, Juhee Son, Shimeng Huang, Qiru Zeng, Traci L Bricker, James Brett Case, Ruochen Zang, Zhuoming Liu, Tamarand L Darling, Jian Xu, Houda H Harastani, Maria Florencia Gomez Castro, Hinissan P Kohio, Gaopeng Hou, Paul W Rothlauf, Adam L Bailey, Steven L Brody, Sean P J Whelan, Michael S Diamond, Adrianus C M Boon, Siyuan Ding, Et Al

Open Access Publications

Pathogenic coronaviruses are a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified small-molecule inhibitors that potently block the replication of severe acute respiratory syndrome virus 2 (SARS-CoV-2). Among them, JIB-04 inhibited SARS-CoV-2 replication in Vero E6 cells with a 50% effective concentration of 695 nM, with a specificity index of greater than 1,000. JIB-04 showed

Comparative Genomics Of Bacteroides Fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms And Validates Clinical Tools For Resistance Prediction, Miranda J Wallace, Sophonie Jean, Meghan A Wallace, Carey-Ann D Burnham, Gautam Dantas

Open Access Publications

Bacteroides fragilis group (BFG) are the most frequently recovered anaerobic bacteria from human infections, and resistance to frontline antibiotics is emerging. In the absence of routine antimicrobial susceptibility testing (AST) for BFG in most clinical settings, we assessed the utility of clinical and modern genomics tools to determine BFG species-level identification and resistance patterns. A total of 174 BFG clinical isolates supplemented with 20 archived carbapenem-resistant B. fragilis

A Fond Farewell, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

In this From the Editor introduction to Volume 9, Issue 1, the retiring editor-in-chief of Journal of Patient-Centered Research and Reviews recalls the history and initial aims of JPCRR, discusses the contents of articles in the current issue, and says good-bye.

Prevalence Of Infectious Diseases Among 6078 Individuals With Down Syndrome In The United States, Veronica Fitzpatrick, Anne Rivelli, Sagar Chaudhari, Laura Chicoine, Gengjie Jia, Andrey Rzhetsky, Brian Chicoine

Journal of Patient-Centered Research and Reviews

A recent disease prevalence study of the largest documented Down syndrome (DS) cohort in the United States strongly suggested significant disparity in general infectious disease conditions among individuals with DS versus those without DS. In this follow-up retrospective analysis, we explored these differences in greater detail by calculating prevalence of 52 infectious diseases, across 28 years of data among 6078 individuals with DS and 30,326 age- and sex-matched controls, abstracted from electronic medical records within a large Midwestern health system. We found that the DS cohort had higher prevalence of pneumonias (including aspiration, viral, bacterial, pneumococcal, and unspecified/atypical); otitis externa; …

Mosquito Edge: An Edge-Intelligent Real-Time Mosquito Threat Prediction Using An Iot-Enabled Hardware System, Shyam Polineni, Om Shastri, Avi Bagchi, Govind Gnanakumar, Sujay Rasamsetti, Prabha Sundaravadivel

Electrical Engineering Faculty Publications and Presentations

Species distribution models (SDMs) that use climate variables to make binary predictions are effective tools for niche prediction in current and future climate scenarios. In this study, a Hutchinson hypervolume is defined with temperature, humidity, air pressure, precipitation, and cloud cover climate vectors collected from the National Oceanic and Atmospheric Administration (NOAA) that were matched to mosquito presence and absence points extracted from NASA's citizen science platform called GLOBE Observer and the National Ecological Observatory Network. An 86% accurate Random Forest model that operates on binary classification was created to predict mosquito threat. Given a location and date input, the …

Synthesis And Biosynthesis Of 3-Hydroxy-Β-Lactam Antibiotics, Wei Wei

Arts & Sciences Graduate Student Theses and Dissertations

Novel treatments for tuberculosis (TB) are urgently needed to conquer this global health crisis. Unlike canonical β-lactam antibiotics that target transpeptidases by hydrolyzing the lactam ring, tabtoxinine-β-lactam (TβL) functions as a potent glutamine synthetase (GS) inhibitor by forming a transition state mimic. TβL has the potential to be used as an anti-TB agent by targeting the nitrogen metabolic pathway of pathogenic mycobacteria. This work reported an innovative, convergent, and flexible cross-metathesis method to obtain the fully protected TβL scaffold. The trans-olefin intermediate provides possibilities for synthesizing various derivatives through alkene functionalization reactions. We also developed and optimized a solid phase …

Challenges In Covid-19 Chest X-Ray Classification: Problematic Data Or Ineffective Approaches?, Muhammad Ridzuan, Ameera Ali Bawazir, Ivo Gollini Navarrete, Ibrahim Almakky, Mohammad Yaqub

Computer Vision Faculty Publications

The value of quick, accurate, and confident diagnoses cannot be undermined to mitigate the effects of COVID-19 infection, particularly for severe cases. Enormous effort has been put towards developing deep learning methods to classify and detect COVID-19 infections from chest radiography images. However, recently some questions have been raised surrounding the clinical viability and effectiveness of such methods. In this work, we carry out extensive experiments on a large COVID-19 chest X-ray dataset to investigate the challenges faced with creating reliable solutions from both the data and machine learning perspectives. Accordingly, we offer an in-depth discussion into the challenges faced …

2022-01-16_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

Full Issue - Human Trafficking Awareness

Journal of Nonprofit Innovation

What are the latest data points about human trafficking and the efforts being made to reduce it in our community? This issue addresses what's happening in the anti-trafficking community.

HUMAN TRAFFICKING DEFINED: The Trafficking Victims Protection Act of 2000, as amended (TVPA), defines “severe forms of trafficking in persons” as:

• sex trafficking in which a commercial sex act is induced by force, fraud, or coercion, or in which the person induced to perform such an act has not attained 18 years of age; or

• the recruitment, harboring, transportation, provision, or obtaining of a person for labor or services, …

Covid-19 Vaccine–Related Misinformation In The Iraqi Community : Covid-19 Vaccine-Related Misinformation In The Iraqi Community, Ali Al-Rubaye, Dhurgham Abdulwahid, Abbas Ejbary, Laith Al-Rubaye, Aymen Albadran

Iraqi National Journal of Medicine

Background: The recent coronavirus (SARS-CoV-2) pandemic has created a serious public health concern worldwide. Shortly after the successful mapping of the genome sequence of SARS-CoV-2 and the declaration of the pandemic by the World Health Organization (WHO) in early 2020, scientists and pharmaceutical companies raced against time in efforts to develop vaccines. As of the 18th of February 2021, the WHO had approved at least seven different vaccines to be rolled out worldwide. However, despite the seriousness of the pandemic and its rapid spread, Iraqi society still refrains from taking vaccines against the disease. Although there is an increase in …

Contrast Enhanced Fluid-Attenuated Inversion Recovery Versus Contrast Enhanced T1-Spin Echo Magnetic Resonance Imaging In The Evaluation Of Infectious Meningitis: Contrast Enhanced Fluid-Attenuated Inversion Recovery Versus Contrast Enhanced T1-Spin Echo Magnetic Resonance Imaging In The Evaluation Of Infectious Meningitis, Husham Abdul-Ra'aoof, Mohammed Al-Khalissi

Iraqi National Journal of Medicine

Background                                                                                                                                         Infectious meningitis is an infection of the subarachnoid space causing inflammation of the leptomeninges. Early diagnosis is crucial to initiate appropriate therapy, avoid complications, and improve prognosis. Cerebrospinal fluid analysis is important in the diagnosis and is done by performing lumbar puncture with some limitations and complications. MRI plays a role in the diagnosis by depicting abnormal leptomeningeal enhancement. Aim of the study To evaluate the efficiency of contrast-enhanced fluid-attenuated inversion recovery compared with contrast-enhanced T1 spin echo in the diagnosis of infectious meningitis. Patients and Methods A prospective analytical study of diagnostic tests was conducted. Brain MRI was …

Prevalence Of Hyponatremia In Patients Admitted To The Oncology Teaching Hospital: Prevalence Of Hyponatremia In Patients Admitted To The Oncology Teaching Hospital, Saba Jasim, Zaineb Faisal, Huda Rasheed

Iraqi National Journal of Medicine

Background: Hyponatremia is a commonly occurring electrolyte disturbance among hospitalized patients, and many studies suggest that individual serum sodium levels may have a prognostic role in assessing probability of mortality. Aim of the study: Determination of hyponatremia prevalence in patients admitted to the Oncology Teaching Hospital. Method: A six-month cross-sectional study of hyponatremia prevalence was conducted in the Oncology ward in Medical City. The patients (105) who were admitted for more than three days with different types of malignancies and causes of admission were investigated for serum sodium, blood urea, random blood sugar, and urinary sodium (single measurement). These results …

One Year Of Covid-19 Infection In Iraq And Emr Countries: One Year Of Covid-19 Infection In Iraq And Emr Countries, Omran Habib, Zahraa Essa

Iraqi National Journal of Medicine

Background : COVID-19 pandemic affected the world for the last 20 months (January 2020-August 2021. It was troublesome, devestating in terms of cases, deaths and socioeconomic consequences and unpredictable in behaviour._x000D_ Objectives : To document comparative profile of the COVID -19 in Iraq and other Eastern Mediterranean Countries in terms of time trend and three epidemiological parameters ( incidence, case fatality and mortality rates)._x000D_ Methods :  A record-based prospective study. Data were checked daily throughout the study period from February 21, 2020 through February 23, 2021. The targeted numbers were recorded on an excel sheet or word table and updated …

Frequency Of Isolation And Antibiotic Resistance Patterns Of Bacterial Isolates From Wound Infections, National Cancer Institute, Wad-Medani, Sudan, 2021: Frequency Of Isolation And Antibiotic Resistance Patterns Of Bacterial Isolates From Wound Infections, National Cancer Institute, Wad-Medani, Sudan, 2021, Omer Mohammed, Abbakar Dawod, Adil Mirghani, Mobaruk Alkarsani, Ameer Dafalla

Iraqi National Journal of Medicine

Background: Disturbance of skin integrity (wound) provides a suitable environment for the growth and multiplication of bacteria. The emerging occurrence and spread of multidrug-resistant microbial pathogens present a significant challenge in providing effective health care and is, therefore, a worldwide medical issue. Aim: The current study reports on the occurrence of possible pathogens associated with wound infections at National Cancer Institute, Wad Madani, Sudan. Methodology: This was a cross-sectional descriptive, hospital-based study including 100 patients with wounds suspected to be infected. Suspicion was dependent on the inability of wounds to heal properly. A structured questionnaire was given to the subjects …

Modeling And Simulation Of Emergency Medical Resources Allocation In Shanghai During Covid-19, Changjia Fan, Yanqiu Du, Liang Di, Hu Kai, Jiayan Huang

Journal of System Simulation

Abstract: Modeling and simulating on the allocation of emergency medical resources in Shanghai with COVID-19 is carried out. Based on the SEIR model of infectious diseases, combined with the process of outpatients visiting and inpatients treatment, a SEIOWHR(susceptible-exposed-infected-outpatients- waiting to hospitalized-hospitalized-removed) system dynamics model is established. If the Wuhan epidemic occurred in Shanghai, based on the model, the amount of emergency medical resources needed, the gap time of medical resources and the disease progression of patients who are waiting to hospitalized under the different supply of medical resources is simulated, and the key factors in the allocation of medical …

Impact Of Pooling Samples On Analytic Sensitivity Of A Real-Time Reverse Transcriptase Pcr Assay For Sars Cov-2, Subathra Marimuthu, Stephen P. Furmanek, Holly Aliesky, Leslie A. Wolf

The University of Louisville Journal of Respiratory Infections

During the COVID-19 pandemic, laboratories experienced periods of shortages for certain critical materials required to meet the high demand for SARS-CoV-2 testing. The U.S. Food & Drug Administration provided a template for molecular diagnostic testing, including guidance for a specimen pooling process in order to evaluate performance of the SARS-CoV-2 nucleic acid amplification assay. This study aimed to evaluate the testing of pooled specimens consisting of four nasopharyngeal swab specimens using the Luminex ARIES^® nucleic acid amplification platform. Results indicated that there was a loss of analytic sensitivity with pooled nasopharyngeal swab samples, demonstrating that this approach should be …

Repertorio Estético-Afectivo De Hombres Anti-Patriarcales: La Construcción De Otras Masculinidades, Jorge A. Jimenez Rodas, Juan C. Arboleda-Ariza, Milton D. Morales Herrera

The Qualitative Report

Los estudios de género en hombres y masculinidades retoman las bases de la crítica feminista para analizar los procesos y subjetividades masculinas. Este proceso ha estado acompañado de la creación cada vez más visible de colectivos de hombres que se oponen a los marcos hegemónicos de la masculinidad y promueven, por medio de un activismo político, versiones alternativas de entender lo masculino. En este trabajo nos preguntamos por el discurso que utilizan estos hombres y las consecuencias de este. Para esto analizamos el discurso de doce hombres latinoamericanos que participan en estos grupos e identificamos a partir de la variabilidad …

Harnessing Mycobacterium Bovis Bcg Trained Immunity To Control Human And Bovine Babesiosis, Reginaldo G. Bastos, Heba F. Alzan, Vignesh A. Rathinasamy, Brian M. Cooke, Odir A. Dellagostin, Raul G. Barletta, Carlos E. Suarez

School of Veterinary and Biomedical Sciences: Faculty Publications

Babesiosis is a disease caused by tickborne hemoprotozoan apicomplexan parasites of the genus Babesia that negatively impacts public health and food security worldwide. Development of effective and sustainable vaccines against babesiosis is currently hindered in part by the absence of definitive host correlates of protection. Despite that, studies in Babesia microti and Babesia bovis, major causative agents of human and bovine babesiosis, respectively, suggest that early activation of innate immune responses is crucial for vertebrates to survive acute infection. Trained immunity (TI) is defined as the development of memory in vertebrate innate immune cells, allowing more efficient responses to subsequent …

Larval Habitats, Species Composition And Distribution Of Malaria Vectors In Regions With Autochthonous And Imported Malaria In Roraima State, Brazil, Nathália Coelho Vargas De Almeida, Jaime Louzada, Maycon Sebastião Alberto Santos Neves, Thiago M. Carvalho, Júlio Castro‑Alves, Teresa Fernandes Silva‑Do‑Nascimento, Ananias A. Escalante, Joseli Oliveira‑Ferreira

Harold W. Manter Laboratory of Parasitology: Library Materials

Background: Malaria control requires local action. Assessing the vector diversity and abundance provides information on the local malariogenic potential or risk of transmission. This study aimed to determine the Anopheles species composition, habitats, seasonal occurrence, and distribution in areas with autochthonous and imported malaria cases in Roraima State.

Methods: A longitudinal study was conducted from January 2017 to October 2018, sampling larvae and adult mosquitoes in three municipalities of Roraima State: Boa Vista, Pacaraima and São João da Baliza. These areas have different risks of malaria importation. Four to six mosquito larval habitats were selected for larval sampling …

Volume 119, Number 5, Friday, January 14th, 2022, Saint Mary's College Of Califiornia

The Collegian

No abstract provided.