Digital Commons Network^™

Online Pathology Education For Medical Students: Lessons Learned During Lockdown In Central Thailand, Thiyaphat Laohawetwanit

Asian Medical Journal and Alternative Medicine

This study aims to demonstrate a use case of asynchronous and synchronous online learning in pathology for medical students during the Novel Coronavirus 2019 (COVID-19) pandemic. Students’performances and preferences were satisfactory. Online learning should be included as a part of the pathology curriculum after the COVID-19 outbreak.

Impact Of Age And Social Distancing On Covid-19 Epidemic In India, Harish Kumar, Sini V. Pillai, Vipin H

Management Dynamics

Corona virus disease 2019 (COVID-19) is an infectious disease with Acute Intense Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), and the World Health Organization (WHO) has proclaimed Covid-19 as a pandemic. The virus can spread quickly through close contact and via respiratory droplets induced when people cough or sneeze. The respective officials have promoted social Distancing, and governing bodies as a precautionary measure to prevent this novel disease as social contacts between people have a solid assortative structure in age. A mathematical model is used to predict the transmission of the disease, including age and social contact structure. In the research …

Competitive Analysis Of Crm Strategies Using Analytic Hierarchy Process, Thani Jambulingam, Maheshkumar P. Joshi, Ravi Kathuria

Management Dynamics

In the era of increasing need for customer-centric marketing, the growth of technology such as the Web-based customer relationship management (CRM) has enabled pharmaceutical firms to develop new capabilities to sustain competitive advantage with superior marketing strategies, which include formulating unique, direct relationships with customers. To compete by integrating the online technologies across all aspects of a firm's operations, translates into the need for developing new skills as traditional ways of competing become insufficient. Towards this end, pharmaceutical firms have seized the opportunity to institute relationships with customers (physicians and patients) with the use of the Web. Our research focused …

A Weighted Probability Measure For Objects In Euclidean Space, Alessandro Xello

Mathematics Colloquium Series

Since we were little kids, we developed our own sense dimension as a measure of some kind of extent. Whether it be length, width, or height, we intuitively understand how these features fit in the three-dimensional world we live in, and how to measure it. Nevertheless, mathematicians have found themselves dealing with objects, like fractals, and spaces, like R4 , that challenge our intuitive and self-developed definition of measure, to the point that it is not sufficient anymore. Lebesgue measure and Harsdorf measure for example are ways of assigning a measure to objects that belong to n-dimensional Euclidean spaces, in …

Strategic Recommendations To Bridge The Gaps In Awareness, Diagnosis And Prevention Of Heart Failure In The Middle East Region And Africa, Ahmed Bennis, Elijah N Ogola, Eric Klug, Hadi N. Skouri, Hilal Bahjet Al Saffar, Hany Ragy, Kamal Waheeb Alghalayini, Khaldoon A Alhumood, Magdy Abdelhamid, Mehmet Birhan Yilmaz, Ramzi Tabbalat, Yüksel Çavuşoğlu

Journal of the Saudi Heart Association

Abstract Objective: With the increasing burden of heart failure (HF) in the Middle East Region and Africa (MEA), it is imperative to shift the focus to prevention and early detection of cardiovascular diseases. We present a broad consensus of the real-world challenges and strategic recommendations for optimising HF care in the MEA region. Method: To bridge the gaps in awareness, prevention, and diagnosis of HF, an assembly of experts from MEA shared their collective opinions on the urgent unmet needs. Results: Lack of awareness in the community, high prevalence of risk factors, poor accessibility and affordability of care and diagnostics …

Reconstructing The Confederate Widow: An Analysis Of The Wives Of Fallen Confederate Soldiers And Their Response To Reconstruction And The Post War Era, Christian Beasley

Campus Research Month

This study provides an analysis of how the post-civil war era and Reconstruction affected the financial, social, and political lives of the wives of fallen Confederate soldiers. Because men were the head of families and traditional breadwinners in the South, the widows of the 258,000 fallen Confederate soldiers had to reintegrate themselves into society and support their families without the assistance and comfort of a husband. Although this integration may seem straightforward, these widows struggled to overcome the economic and social difficulties laid before them, including the patriarchal traditions, mourning expectations, severe droughts, and unemployment that plagued these women. This …

Late Xix - Early Xx Century Historywriting In Bukhara Emirate, Vazira Ismatovna Sadullaeva

Scientific reports of Bukhara State University

Introduction. In theEmirate of Bukhara in the late XIX - early XX centuries, although the natural and exact sciences fell to the second level, the social sciences, including history, literature, philosophy, mysticism, developed significantly. Historians Ahmad Donish (1827-1897), Mirzo Somi (1838-1907), Mirzo Salimbek (1850-1930), Sadr Ziyo (1867-1931), Tamkin Bukhari, Abdulazim Shar'i (1839-1893), Mir Rare works on history have been created by Siddiq Hashmat, Muhammad Ikram Abdulsalam, Nosiriddin Tora. Research methods. The influence of reformist ideas in the emirate had a profound effect on the development of local historiography as well as on political and cultural life. Historians began to study …

The Effects Of Partisan Framing On Covid-19 Attitudes: Experimental Evidence From Early And Late Pandemic, Amber Wichowsky, Meghan Condon

Political Science: Faculty Publications and Other Works

Political polarization has dominated news coverage of Americans’ responses to the COVID-19 pandemic. In this research note, we report findings from two experimental studies, in which we present respondents with news stories about COVID-19 mitigation measures that emphasize partisan difference or accord. The stories present the same numeric facts about public opinion, but highlight either the partisan gap that existed at the time of the study, or the fact that large majorities of both Republicans and Democrats supported the measures at the time. Results from our first study, conducted late April 2020, show that a media frame drawing attention to …

Roadway-Associated Culverts May Serve As A Transmission Corridor For Pseudogymnoascus Destructans And White-Nose Syndrome In The Coastal Plains And Coastal Region Of Georgia, Usa, Kelly E. Lutsch, Ashley G. Mcdonald, Kyle T. Gabriel, Christopher T. Cornelison

KIP Articles

White-nose syndrome (WNS) is a disease among hibernating North American bats caused by the psychrophilic fungus Pseudogymnoascus destructans. Since its discovery in New York state, US, in 2006, and as of 2020, WNS has rapidly spread to 34 American states and seven Canadian provinces, causing precipitous declines of native bat populations across North America. The rapid spread of this fungal pathogen has been facilitated by the social behavior of bats, as well as the ability of subterranean hibernacula to support a favorable environment for P. destructans, and is probably exacerbated by anthropogenic transmission events. Although many bat species roost in …

High Level Of Persister Frequency In Clinical Staphylococcal Isolates, Sarita Manandhar, Anjana Singh, Ajit Varma, Shanti Pandey, Neeraj Shrivastava

Faculty Publications

Staphylococcus aureus is a notorious human pathogen that causes often lethal systemic conditions that are mostly medical device associated biofilm infections. Similarly, coagulase negative staphylococci are emerging as leading pathogen for nosocomial infections owing to their ability to form biofilm on implanted medical equipment. Chronic in nature, these infections are difficult to treat. Such recalcitrance of these infections is caused mainly due to the presence of persister cells, which exhibit transient yet extreme tolerance to antibiotics. Despite tremendous clinical significance, there is lack of studies on persister cells formation among clinical bacterial isolates. Considering the importance of factors influencing persister …

Promotion Of Covid-19 Va(X)Ccination In The Emergency Department-Procovaxed: Study Protocol For A Cluster Randomized Controlled Trial., Robert M Rodriguez, Kelli O'Laughlin, Stephanie A Eucker, Anna Marie Chang, Kristin L. Rising, Graham Nichol, Alena Pauley, Hemal Kanzaria, Alexzandra Gentsch, Cindy Li, Herbie Duber, Jonathan Butler, Vidya Eswaran, Dave Glidden

Department of Emergency Medicine Faculty Papers

Background: We conducted in-depth interviews to characterize reasons for COVID-19 vaccine hesitancy in emergency department (ED) patients and developed messaging platforms that may address their concerns. In this trial, we seek to determine whether provision of these COVID-19 vaccine messaging platforms in EDs will be associated with greater COVID-19 vaccine acceptance and uptake in unvaccinated ED patients.

Methods: This is a cluster-randomized controlled trial (RCT) evaluating our COVID-19 vaccine messaging platforms in seven hospital EDs (mix of academic, community, and safety-net EDs) in four US cities. Within each study site, we randomized 30 1-week periods to the intervention and 30 …

Murine Respiratory Tract Infection With Classical Klebsiella Pneumoniae Induces Bronchus-Associated Lymphoid Tissue, Rachel K Wasbotten, Aubree A Dahler, Joseph J Mackel, Catherine Morffy Smith, David A Rosen

Open Access Publications

Klebsiella pneumoniae is a Gram-negative, opportunistic pathogen that commonly causes nosocomial pneumonia, urinary tract infection, and septicemia. Our recent work utilizing a murine model of respiratory tract infection with classical K. pneumoniae demonstrated leukocyte aggregates in the lungs of mice at 28 days postinfection. Here, we sought to characterize the composition and development of these structures. Histopathological analyses of murine lungs revealed immune cell clusters surrounding the pulmonary vasculature and airways by 14 days postinfection, resembling inducible bronchus-associated lymphoid tissue (iBALT). Further investigation of these structures demonstrated central B cell aggregates with concomitant dispersed T cells. At day 28 postinfection, …

The Effects Of Covid-19 On Well-Being Of Healthcare Workers, Hannah Meissner

Honors Theses

The development of the new coronavirus disease, COVID-19, led to the spread of turmoil across the United States and further around the globe. With the virus creating uncertainty among the population, the evidence began to demonstrate that individuals could have devastating health effects, including death. Healthcare workers are among those who were on the frontlines in order to care for the infected, ultimately increasing their own chances of acquiring the virus and putting their health at risk. These workers have experienced a direct impact due to this exposure in the form of isolation, anxiety, depression, suicide, and sleep disturbances. With …

Meal Timing, Meal Frequency And Metabolic Syndrome, Fatema Alkhulaifi, Charles Darkoh

Faculty, Staff and Student Publications

Individuals with metabolic syndrome have increased risk for developing health conditions, including cardiovascular diseases and stroke. Modifiable risk factors, such as exercise and diet, are key components in the prevention and control of metabolic syndrome. Specifically, dietary patterns and habits are extremely successful in controlling more than one of the metabolic syndrome risk factors. Meal timing and frequency have been associated with type 2 diabetes, cardiovascular diseases, and other chronic conditions. However, there is limited evidence linking metabolic syndrome to meal timing and meal frequency. This review summarizes and discusses how meal timing and frequency impact metabolic outcomes in adults.

Outcomes Of Covid-19 Infection In Patients With Hematological Malignancies- A Multicenter Analysis From Pakistan, Adeeba Zaki, Salman Muhammad Soomar, Danish Hasan Khan, Hasan Shaharyar Sheikh, Raheel Iftikhar, Ayaz Mir, Zeba Aziz, Khadija Bano, Hafsa Naseer, Qamar Un-Nisa Chaudhry

Section of Haematology/Oncology

Purpose: COVID-19 infection resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began to spread across the globe in early 2020. Patients with hematologic malignancies are supposed to have an increased risk of mortality from coronavirus disease of 2019 (COVID-19) infection. From Pakistan, we report the analysis of the outcome and interaction between patient demographics and tumor subtype and COVID-19 infection and hematological malignancy.
Patients and methods: This multicenter, retrospective study included adult patients with a history of histologically proven hematological malignancies who were tested positive for COVID-19 via PCR presented at the oncology department of 5 tertiary care hospitals …

Louisiana Certified Child Life Specialists’ Perspective On The Effects Of Covid-19 On Child Life Services, Abby Johnson

LSU Master's Theses

The medical field has faced challenges throughout the COVID-19 pandemic, significantly changing the ways hospitals function and healthcare professionals serve patients and families. Healthcare professionals, specifically Certified Child Life Specialists (CCLSs), have continuously adapted their roles, programs, and services to ensure they adhere to the ever-changing infection control policies and mitigation efforts put in place by government officials and institutions. CCLSs provide pediatric patients and their families with interventions, hospital normalization, and opportunities to engage in play, contributing to pediatric patients’ healing environment during hospitalization. This study focuses on pediatric healthcare in the state of Louisiana, gaining insight from CCLSs’ …

Food Security: A Study Of The History Of Nutritional Insecurity And Implications Of Development In The Rural Sierra And Selva Regions Of Peru, Jane Morrissey

Undergraduate Honors Theses

This study looks at the history of food insecurity in Peru, ranging from 1969 to 2021. The main contribution this paper seeks to make is to create a holistic approach at viewing the historical causes and consequences of food insecurity in Peru, particularly in the rural mountainous regions of the country. These areas range from the southeastern, eastern, and northeastern towns near Lima, with case studies from towns such as Ayacucho, San Martin, Huaycan, Socos, Banda de Shilcayo, and Sapote. Different levels of effective food security can be observed from the oppressive political overthrow of agriculture production in the 1960s …

April 20, 2022 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

Preclinical Characterization And Target Validation Of The Antimalarial Pantothenamide Mmv693183., Laura E. De Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M J Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering

Natural Sciences and Mathematics | Faculty Scholarship

Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor to enter preclinical development. Our studies demonstrate attractive drug-like properties and in vivo efficacy in a humanized mouse model of Plasmodium falciparum infection. The compound shows single digit nanomolar in vitro activity against P. falciparum and P. vivax clinical isolates, and potently blocks P. falciparum transmission to Anopheles mosquitoes. Genetic and biochemical studies identify AcAS as the target of the MMV693183-derived antimetabolite, CoA-MMV693183. Pharmacokinetic-pharmacodynamic modelling predict that a single 30 mg oral dose is sufficient …

Implementing Environmentally Informed Occupational Therapy In Clinical Practice Settings, Chelsea A. Heilbrun

MOT Student Capstones

Anthropogenic environmental decline and associated climate change is causing negative health and wellness and consequently occupational injustices. As human activity continues to be the largest contributing factor to environmental degradation, sustainability practices are essential now more than ever to remediate ecological damages for the health, wellbeing, and occupational justice of current and future generations. Occupational therapy (OT) is an occupation-based profession and therefore implies a focus on human activity with an underlying responsibility to promote environmental sustainability. OT practitioners have a unique ability to support client engagement and participation in ecosystem conservation and sustainability. The purpose of this paper was …

Mainehealth As A Partner In The National Covid Cohort Collaborative (N3c), Susan Santangelo, Kimberly Murray, Kathleen M. Fairfield, John Dipalazzo, Ivette Emery, Cliff Rosen

Costas T. Lambrew Research Retreat 2022

N3C is a secure clinical data analytics platform hosted at the NIH that includes vast amounts of data from a large network of he alth care organizations, including MaineHealth , to accelerate advances in COVID 19 research and clinical care.

Sotrovimab: Neutralizing Antibody To Combat Covid-19, Aya Allam, Steven Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Nanoparticulate Carriers For Drug Delivery, Samantha Lokelani Crossen, Tarun Goswami

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Drug delivery with nanoparticulate carriers is a new and upcoming research area that is making major changes within the pharmaceutical industry. Nanoparticulate carriers are discussed, particularly, engineered nanoparticulate carriers used as drug delivery systems for targeted delivery. Nanoparticulate carriers that are used for drug delivery systems include polymers, micelles, dendrimers, liposomes, ceramics, metals, and various forms of biological materials. The properties of these nanoparticulate carriers are very advantageous for targeted drug delivery and result in efficient drug accumulation at the targeted area of interest, reduced drug toxicity, reduced systemic side effects, and more efficient use of the drug overall. Nanoparticlulate …

Passive Sampling To Scale Wastewater Surveillance Of Infectious Disease: Lessons Learned From Covid-19, Aaron Bivins, Devrim Kaya, Warish Ahmed, Joe Brown, Caitlyn Butler, Justin Greaves, Reann Leal, Kendra Maas, Gouthami Rao, Samendra Sherchan, Deborah Sills, Ryan Sinclair, Robert T. Wheeler, Cresten Mansfeldt

Faculty Journal Articles

Much of what is known and theorized concerning passive sampling techniques has been developed considering chemical analytes. Yet, historically, biological analytes, such as Salmonella typhi, have been collected from wastewater via passive sampling with Moore swabs. In response to the COVID-19 pandemic, passive sampling is re-emerging as a promising technique to monitor SARS-CoV-2 RNA in wastewater. Method comparisons and disease surveillance using composite, grab, and passive sampling for SARS-CoV-2 RNA detection have found passive sampling with a variety of materials routinely produced qualitative results superior to grab samples and useful for sub-sewershed surveillance of COVID-19. Among individual studies, SARS-CoV-2 RNA …

Are Antipyretic Medications Compatible With Sars-Cov-2 Vaccines?, Sharanya S E Santhi, Niguma Rayamajhi, Steven B Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

The Impact Of Implementing The Virtuo Blood Culture System On The Characteristics And Management Of Patients With Staphylococcus Aureus Bacteremia, Miguel A Chavez, Satish Munigala, Carey-Ann D Burnham, Melanie L Yarbrough, David K Warren

Open Access Publications

Persistent Staphylococcus aureus bacteremia (SAB) has been associated with increased mortality. Enhanced microbial detection with new blood culture technology may improve detection of S. aureus in patients with SAB. We performed a 24-month retrospective study of hospitalized adults with SAB and an infectious diseases consult comparing two time periods pre- (January to December 2018) and postimplementation (January to December 2019) in which the VersaTREK and BacT/Alert Virtuo blood culture systems were used, respectively. Measurements included SAB duration, time to positivity, source of bacteremia, antimicrobial therapy, and mortality. A total of 416 episodes of SAB occurred during the study period: 176 …

Persistent Methicillin-Susceptible Bacteremia Rapidly Cleared With Cefazolin And Ertapenem Combination Therapy In A Patient With Covid-19, Dan Ilges, Gayathri Krishnan, Elvin Geng

Open Access Publications

Methicillin-susceptible

Development And Validation Of The Rcos Prognostic Index: A Bedside Multivariable Logistic Regression Model To Predict Hypoxaemia Or Death In Patients With Sars-Cov-2 Infection, Gerardo Alvarez-Uria, Sumanth Gandra, Venkata R Gurram, Raghu P Reddy, Manoranjan Midde, Praveen Kumar, Ketty E Arce

Open Access Publications

Introduction: Previous COVID-19 prognostic models have been developed in hospital settings and are not applicable to COVID-19 cases in the general population. There is an urgent need for prognostic scores aimed to identify patients at high risk of complications at the time of COVID-19 diagnosis.

Methods: The RDT COVID-19 Observational Study (RCOS) collected clinical data from patients with COVID-19 admitted regardless of the severity of their symptoms in a general hospital in India. We aimed to develop and validate a simple bedside prognostic score to predict the risk of hypoxaemia or death.

Results: 4035 patients were included in the development …

The Role Of Wolves In Regulating A Chronic Non-Communicable Disease, Osteoarthritis, In Prey Populations, Sarah Hoy, John A. Vucetich, Rolf O. Peterson

Michigan Tech Publications, Part 1

It is widely accepted that predators disproportionately prey on individuals that are old, weak, diseased or injured. By selectively removing individuals with diseases, predators may play an important role in regulating the overall health of prey populations. However, that idea is seldom tested empirically. Here we assess the extent that wolves (Canis lupus) select adult moose (Alces alces) in Isle Royale National Park on the basis of age-class and osteoarthritis, a chronic, non-communicable disease. We also assess how temporal variation in kill rates (on moose by wolves) were associated with the subsequent incidence of osteoarthritis in the moose population over …

Baseline Health And Nutritional Parameters Of Wild Sand Tigers Carcharias Taurus Sampled In Delaware Bay, Lisa A. Hoopes, Tonya M. Clauss, Bradley M. Wetherbee, Dewayne A. Fox

Marine & Environmental Sciences Faculty Articles

Species-specific hematological reference values are essential for diagnosis and treatment of disease and maintaining overall health of animals. This information is lacking for many species of elasmobranchs maintained in zoos and aquaria, thus reducing the effectiveness of care for these animals. Descriptive statistics and reference intervals were calculated for hematocrit and complete blood cell counts, biochemistry and protein electrophoresis parameters, trace minerals, vitamins, heavy metals, reproductive hormones, and fatty acids in the blood of 153 wild Sand Tigers Carcharias taurus of both sexes and a range of sizes caught in Delaware Bay (Delaware, USA). Mean hematocrit, total white blood cell …